Ole Andreassen

2013 -  Director Centre of Excellence NORMENT, Professor, University of Oslo
2006 -  Attending psychiatrist (20 %), Outpatient clinic, Oslo University Hospital
2020 -  Co-director KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo

Previous: 

2012-2018: Director KG Jebsen Centre for Psychosis Research
2011-2012: Visiting Professor, UCSD, USA
2005-2011: Professor in Psychiatry, University of Oslo; Attending Psychiatrist, Oslo University Hospital
2001-2005: Combined position Resident Psychiatry, Oslo University Hospital - Ullevål; Senior Scientist, University of Oslo
2000-2001: Resident Dept. of Psychiatry, Oslo University Hospital - Ullevål
1998-2000: Post Doc, Massachusetts General Hospital, Harvard Medical School, USA
1996-1998: Internship Dept. of Surgery, Internal Medicine, Family Medicine, Stavanger University Hospital, Norway
1993-1996: PhD Research Fellow, Dept. of Physiology, University of Bergen, Norway

Editorial Board: Schizophr Bull, Acta Psych Scand, W J Biol Psych, Eur J Pharmacol, Acta Neuropsychiatrica.

Ad hoc referee: New Engl J Med, Nat Genet, Nat Med, Nat Commun, Lancet, BMJ, PNAS, Mol Psychiatry, JCI, Am J Psychiatry, JAMA Psychiatry, Biol Psychiatry, Schizophr Bull, Transl Psych, Neuropsychopharmacology, J Clin Psychiatry, Schizophr Res, Prog Neurobiol, J Psych Res, Int J Neuropharm, Pharmacogenom J, Cereb Cortex, Neurobiol Dis, J Neurochem, J Psych Neurosci, J Affect Disord, Neuromolecular Med.

Grant review: Canadian Medical Research Council (RC), Neurological Foundation New Zealand, RC of Spain, AERES France, ANR France, Faroe Island RC, Irish RC, BBSRC, Austrian RC, Wellcome Trust, UPEC, MRC, EU ERA-NET, Dutch RC, Swiss RC, Swedish RC, Danish RC, German RC, Univ. Lyon, Univ. Copenhagen, Karolinska Inst., Oslo Univ. Hospital, West Norway Health Region, ERC Starting Grants, Northern Norway Health Region, Univ Montpellier HCERES.

Promotions: Univ. Copenhagen, Univ. Pittsburgh, Duke Univ., UCSD, Karolinska Inst., Univ. Bergen, Norwegian Univ. Science Technology, Univ. Helsinki, Univ Aarhus, South Africa RC, UCSF, UCL

PhD adjudication: Univ. Bergen 3, NTNU 3, Univ. Copenhagen 3, Univ. Gothenburg 1, Karolinska Inst. 1, Univ. Oslo 2. Lausanne Univ: 1, Univ Basel 1, Cardiff Univ 1, KCL 1.

RESEARCH LEADERSHIP, ADMIN. EXPERIENCE

Ten representative publications from the last 10 years, main author:

1. Andreassen OA, Djurovic S, … Dale AM. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92(2):197-209. 
2. Hibar DP, .. .. Andreassen OA. Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry. 2016 Feb 9  21 (12), 1710. 
3. Lo MT, Hinds DA, ..Andreassen OA*, CH Chen*. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat Genet 2017;49:152-6. 
4. Hibar DP,..Andreassen OA. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018;23(4):932-942. 
5. Stahl EA, Breen G,… Andreassen OA*, Kelsoe J*, Sklar P*. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51(5):793-803. 
6. Jansen IE, .. Andreassen OA*, Posthuma D*. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat Genet. 2019;51(3):404-413. 
7. Frei O, Holland D,...Andreassen OA*, Dale AM*. Bivariate Causal Mixture Model Quantifies Polygenic Overlap Between Complex Traits Beyond Genetic Correlation. Nat Commun 2019;10:2417. 
8. Smeland OB,....Andreassen OA. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry 2020;25(4):844-853 
9. Bahrami S,  ……Andreassen OA. Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study. JAMA Psychiatry. 2020 77:1-11. 
10. Mulins M, …Andreassen OA. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology, Nat Genet 2021 Jun;53(6):817-829.

• Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent; Ahmad, Shahzad & Ikram, M. Arfan [Show all 28 contributors for this article] (2022). Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping. Alzheimer's Research & Therapy. ISSN 1758-9193. 14(1). doi: 10.1186/s13195-022-00962-4.
• Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil & Bigdeli, Tim B. [Show all 434 contributors for this article] (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. ISSN 0028-0836. 604(7906), p. 502–508. doi: 10.1038/s41586-022-04434-5.
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis. Translational Psychiatry. ISSN 2158-3188. 12(1). doi: 10.1038/s41398-022-01811-6.
• Pardiñas, Antonio F.; Smart, Sophie E.; Willcocks, Isabella R.; Holmans, Peter A.; Dennison, Charlotte A. & Lynham, Amy J. [Show all 70 contributors for this article] (2022). Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia. JAMA psychiatry. ISSN 2168-6238. 79(3), p. 260–269. doi: 10.1001/jamapsychiatry.2021.3799.
• Kjelkenes, Rikka; Wolfers, Thomas; Alnæs, Dag; van der Meer, Dennis; Pedersen, Mads Lund & Dahl, Andreas [Show all 12 contributors for this article] (2022). Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth. biological psychiatry: global open science. ISSN 2667-1743. doi: 10.1016/j.bpsgos.2022.01.007.
• Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr & Shadrin, Alexey [Show all 39 contributors for this article] (2022). Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain. ISSN 0006-8950. 145(1), p. 142–153. doi: 10.1093/brain/awab267.
• Løkhammer, Solveig; Stavrum, Anne-Kristin Støbakk; Polushina, Tatiana; Aas, Monica; Ottesen, Akiah & Andreassen, Ole [Show all 8 contributors for this article] (2022). An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD. Translational Psychiatry. ISSN 2158-3188. 12. doi: 10.1038/s41398-022-01936-8.
• Brouwer, Rachel M.; Klein, Marieke; Grasby, Katrina L.; Schnack, Hugo G.; Jahanshad, Neda & Teeuw, Jalmar [Show all 200 contributors for this article] (2022). Genetic variants associated with longitudinal changes in brain structure across the lifespan. Nature Neuroscience. ISSN 1097-6256. 25(4), p. 421–432. doi: 10.1038/s41593-022-01042-4.
• Burdick, Katherine E.; Millett, Caitlin E.; Yocum, Anastasia K.; Altimus, Cara M.; Andreassen, Ole & Aubin, Valerie [Show all 50 contributors for this article] (2022). Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative. Bipolar Disorders. ISSN 1398-5647. p. 1–11. doi: 10.1111/bdi.13208.
• Beck, Dani; de Lange, Ann-Marie Glasø; Alnæs, Dag; Maximov, Ivan; Pedersen, Mads Lund & Leinhard, Olof Dahlqvist [Show all 20 contributors for this article] (2022). Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults. NeuroImage: Clinical. ISSN 2213-1582. 33. doi: 10.1016/j.nicl.2022.102949.
• Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia & Amin, Najaf [Show all 403 contributors for this article] (2022). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics. ISSN 1061-4036. 54(4), p. 412–436. doi: 10.1038/s41588-022-01024-z.
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 116. doi: 10.1016/j.pnpbp.2022.110511.
• Johansen, Ingrid Torp; Steen, Nils Eiel; Haram, Marit; Rødevand, Linn ; Werner, Maren Caroline Frogner & Lunding, Synve Hoffart [Show all 12 contributors for this article] (2022). Sex differences in antipsychotic-related triglyceride levels are associated with metabolic hormone differences in patients with severe mental disorders. Schizophrenia Research. ISSN 0920-9964. 243, p. 55–63. doi: 10.1016/j.schres.2022.02.015.
• Subramaniapillai, Sivaniya; Suri, Sana; Barth, Claudia; Maximov, Ivan; Voldsbekk, Irene & van der Meer, Dennis [Show all 13 contributors for this article] (2022). Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25882.
• Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius & Bacelis, Jonas [Show all 18 contributors for this article] (2022). Characterization of the genetic architecture of infant and early childhood body mass index. Nature Metabolism. 4, p. 344–358. doi: 10.1038/s42255-022-00549-1.
• Rokicki, Jaroslav; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; van der Meer, Dennis; Bahrami, Shahram & Sartorius, Alina [Show all 14 contributors for this article] (2022). Oxytocin receptor expression patterns in the human brain across development. Neuropsychopharmacology. ISSN 0893-133X. doi: 10.1038/s41386-022-01305-5.
• McInnis, Melvin G.; Andreassen, Ole; Andreazza, Ana C; Alon, Uri; Berk, Michael & Brister, Teri [Show all 18 contributors for this article] (2022). Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder. Bipolar Disorders. ISSN 1398-5647. doi: 10.1111/bdi.13198.
• Magnúsdóttir, Ingibjörg; Lovik, Anikó; Unnarsdóttir, Anna Bára; McCartney, Daniel L.; Ask, Helga & Kõiv, Kadri [Show all 25 contributors for this article] (2022). Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study. The Lancet Public Health. ISSN 2468-2667. doi: 10.1016/S2468-2667%2822%2900042-1.
• Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C. & Galfalvy, Hanga [Show all 50 contributors for this article] (2022). Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biological Psychiatry. ISSN 0006-3223. 91(3), p. 313–327. doi: 10.1016/j.biopsych.2021.05.029. Full text in Research Archive
• Ringen, Petter Andreas; Lund-Stenvold, Elisabeth Haug; Andreassen, Ole; Gaarden, Torfinn Lødøen; Hartberg, Cecilie Bhandari & Johnsen, Erik [Show all 14 contributors for this article] (2022). Quality of clinical management of cardiometabolic risk factors in patients with severe mental illness in a specialist mental health care setting. Nordic Journal of Psychiatry. ISSN 0803-9488. doi: 10.1080/08039488.2022.2039288.
• Mørch-Johnsen, Lynn Egeland; Smelror, Runar; Andreou, Dimitrios; Barth, Claudia; Johannessen, Cecilie Haggag & Wedervang-Resell, Kirsten [Show all 15 contributors for this article] (2022). Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis. Frontiers in Psychiatry. ISSN 1664-0640. doi: 10.3389/fpsyt.2021.825681.
• Frangou, Sophia; Agartz, Ingrid; Alnæs, Dag; Andreassen, Ole; Doan, Nhat Trung & Dørum, Erlend S. [Show all 13 contributors for this article] (2022). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human Brain Mapping. ISSN 1065-9471. 43(1), p. 431–451. doi: 10.1002/hbm.25364.
• Dima, Danai; Agartz, Ingrid; Alnæs, Dag; Andreassen, Ole; Doan, Nhat Trung & Dørum, Erlend Solberg [Show all 12 contributors for this article] (2022). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. ISSN 1065-9471. 43(1). doi: 10.1002/hbm.25320.
• Blokland, Gabriella A. M.; Grove, Jakob; Chen, Chia-Yen; Cotsapas, Chris; Tobet, Stuart & Handa, Robert [Show all 50 contributors for this article] (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. ISSN 0006-3223. 91, p. 102–117. doi: 10.1016/j.biopsych.2021.02.972.
• Reininghaus, Eva Z.; Manchia, Mirko; Dalkner, Nina; Bonkat, Nina; Squassina, Alessio & Hodl, Isabel [Show all 33 contributors for this article] (2021). Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review. European Neuropsychopharmacology. ISSN 0924-977X. 54, p. 90–99. doi: 10.1016/j.euroneuro.2021.09.001. Full text in Research Archive
• Maihofer, Adam X.; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Denckla, Christy A. & Ketema, Elizabeth [Show all 181 contributors for this article] (2021). Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.09.020. Full text in Research Archive
• Heilbronner, Urs; Streit, Fabian; Vogl, Thomas; Senner, Fanny; Schaupp, Sabrina K. & Reich-Erkelenz, Daniela [Show all 51 contributors for this article] (2021). Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection. BJPsych Open. ISSN 2056-4724. 7. doi: 10.1192/bjo.2021.1030.
• McWhinney, Sean R.; Abé, Christoph; Alda, Martin; Benedetti, Francesco; Bøen, Erlend & del Mar Bonnin, Caterina [Show all 51 contributors for this article] (2021). Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals. Molecular Psychiatry. ISSN 1359-4184. 26(11), p. 6806–6819. doi: 10.1038/s41380-021-01098-x. Full text in Research Archive
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun C.; Thompson, Wesley; Eeles, Rosalind A. & Kote-Jarai, Zsofia [Show all 51 contributors for this article] (2021). Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. 24, p. 532–541. doi: 10.1038/s41391-020-00311-2.
• Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2021). Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 112. doi: 10.1016/j.pnpbp.2021.110408. Full text in Research Archive
• Wang, Hao; Rosenthal, Brin Sara; Makowski, Carolina; Lo, Min-Tzu; Andreassen, Ole & Salem, Rany M. [Show all 8 contributors for this article] (2021). Causal association of cognitive reserve on Alzheimer’s disease with putative sex difference. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. ISSN 2352-8729. 13(1). doi: 10.1002/dad2.12270. Full text in Research Archive
• Kalman, Janos L.; Loohuis, Loes M. Olde; Vreeker, Annabel; McQuillin, Andrew; Stahl, Eli A. & Ruderfer, Douglas [Show all 50 contributors for this article] (2021). Characterisation of age and polarity at onset in bipolar disorder. British Journal of Psychiatry. ISSN 0007-1250. 219(6), p. 659–669. doi: 10.1192/bjp.2021.102. Full text in Research Archive
• Peterson, Roseann E.; Bigdeli, Tim B.; Ripke, Stephan; Bacanu, Silviu-Alin; Gejman, Pablo V. & Levinson, Douglas F. [Show all 25 contributors for this article] (2021). Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium. Journal of Psychiatric Research. ISSN 0022-3956. 137, p. 215–224. doi: 10.1016/j.jpsychires.2021.02.027.
• Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan A.; Thompson, Wesley K.; Martinez, Maria Elena & Eeles, Rosalind A. [Show all 78 contributors for this article] (2021). Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-21287-0.
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Thompson, Wesley K.; Lui, Asona & Martinez, Maria Elena [Show all 48 contributors for this article] (2021). Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. doi: 10.1038/s41391-021-00403-7.
• Radonjić, Nevena V.; Hess, Jonathan L.; Rovira, Paula; Andreassen, Ole; Buitelaar, Jan & Ching, Christopher [Show all 19 contributors for this article] (2021). Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 26(6), p. 2101–2110. doi: 10.1038/s41380-020-01002-z. Full text in Research Archive
• Watson, H; et, al.; Andreassen, Ole; Ask, Helga; et, al. & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Common Genetic Variation And Age at Onset Of Anorexia Nervosa. biological psychiatry: global open science. ISSN 2667-1743.
• Sumner, Jennifer A.; Maihofer, Adam X.; Michopoulos, Vasiliki; Rothbaum, Alex O.; Almli, Lynn M. & Andreassen, Ole [Show all 50 contributors for this article] (2021). Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis. Frontiers in Neuroscience. ISSN 1662-4548. doi: 10.3389/fnins.2021.678503. Full text in Research Archive
• Wang, Hao; Lo, Min-Tzu; Rosenthal, Sara Brin; Makowski, Carolina; Andreassen, Ole & Salem, Rany M [Show all 9 contributors for this article] (2021). Similar Genetic Architecture of Alzheimer's Disease and Differential APOE Effect Between Sexes. Frontiers in Aging Neuroscience. ISSN 1663-4365. doi: 10.3389/fnagi.2021.674318. Full text in Research Archive
• Williams, McKenna E.; Elman, Jeremy A.; McEvoy, Linda K.; Andreassen, Ole; Dale, Anders M. & Eglit, Graham M. L. [Show all 27 contributors for this article] (2021). 12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56. Brain Communications. ISSN 2632-1297. doi: 10.1093/braincomms/fcab167. Full text in Research Archive
• Huynh-Le, Minh-Phuong; Karunamuni, Roshan; Fan, Chun-Chieh; Thompson, Wesley K; Muir, Kenneth & Lophatananon, Artitaya [Show all 13 contributors for this article] (2021). Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men. Prostate Cancer and Prostatic Diseases. ISSN 1365-7852. doi: 10.1038/s41391-021-00341-4.
• Arango, Celso; Dragioti, Elena; Solmi, Marco; Cortese, Samuele; Domschke, Katharina & Murray, Robin M. [Show all 14 contributors for this article] (2021). Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas. World Psychiatry. ISSN 1723-8617. doi: 10.1002/wps.20894.
• Winterton, Adriano; Bettella, Francesco; de Lange, Ann-Marie Glasø; Haram, Marit; Steen, Nils Eiel & Westlye, Lars Tjelta [Show all 8 contributors for this article] (2021). Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01725-9. Full text in Research Archive
• Smit, Dirk J. A.; Andreassen, Ole; Boomsma, Dorret I.; Burwell, Scott J.; Chorlian, David B. & De Geus, Eco J C [Show all 28 contributors for this article] (2021). Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. Brain and Behavior. ISSN 2162-3279. 11(8). doi: 10.1002/brb3.2188. Full text in Research Archive
• Lam, Max; Chen, Chia-Yen; Ge, Tian; Xia, Yan; Hill, David W. & Trampush, Joey W. [Show all 71 contributors for this article] (2021). Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics. Neuropsychopharmacology. ISSN 0893-133X. 46(10), p. 1788–1801. doi: 10.1038/s41386-021-01023-4. Full text in Research Archive
• Mullins, Niamh; Forstner, Andreas J.; O'Connell, Kevin Sean; Coombes, Brandon; Coleman, Jonathan R. I. & Qiao, Zhen [Show all 59 contributors for this article] (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics. ISSN 1061-4036. 53, p. 817–829. doi: 10.1038/s41588-021-00857-4.
• Bauer, Michael; Glenn, Tasha; Achtyes, Eric D.; Alda, Martin; Agaoglu, Esen & Altınbaş, Kürşat [Show all 50 contributors for this article] (2021). Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder. International journal of bipolar disorders. ISSN 2194-7511. 9. doi: 10.1186/s40345-021-00231-7. Full text in Research Archive Show summary

  Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.

• Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José & Flores, Susana Gil [Show all 50 contributors for this article] (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 26, p. 1286–1298. doi: 10.1038/s41380-019-0558-2. Full text in Research Archive
• van der Meer, Dennis; Kaufmann, Tobias; Shadrin, Alexey; Makowski, Carolina; Frei, Oleksandr & Roelfs, Daniel [Show all 17 contributors for this article] (2021). The genetic architecture of human cortical folding. Science Advances. ISSN 2375-2548. 7(51), p. 1–9. doi: 10.1126/sciadv.abj9446. Full text in Research Archive
• Unnarsdóttir, Anna Bára; Lovik, Anikó; Fawns-Ritchie, Chloe; Ask, Helga; Kõiv, Kadri & Hagen, Kristen [Show all 52 contributors for this article] (2021). Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations. International Journal of Epidemiology. ISSN 0300-5771. p. 1–15. doi: 10.1093/ije/dyab234. Full text in Research Archive
• Lund, Martina Jonette; Alnæs, Dag; de Lange, Ann-Marie Glasø; Andreassen, Ole; Westlye, Lars Tjelta & Kaufmann, Tobias (2021). Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms. NeuroImage: Clinical. ISSN 2213-1582. doi: 10.1016/j.nicl.2021.102921. Full text in Research Archive
• McWhinney, Sean R.; Abé, Christoph; Alda, Martin; Benedetti, Francesco; Bøen, Erlend & del Mar Bonnin, Caterina [Show all 75 contributors for this article] (2021). Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness—ENIGMA study in 2436 individuals. Bipolar Disorders. ISSN 1398-5647. p. 1–12. doi: 10.1111/bdi.13172.
• Wortinger, Laura Anne ; Barth, Claudia; Nerland, Stener; Jørgensen, Kjetil Nordbø; Shadrin, Alexey & Szabo, Attila [Show all 11 contributors for this article] (2021). Association of Birth Asphyxia With Regional White Matter Abnormalities Among Patients With Schizophrenia and Bipolar Disorders. JAMA Network Open. ISSN 2574-3805. 4(12). doi: 10.1001/jamanetworkopen.2021.39759. Full text in Research Archive Show summary

  Importance: White matter (WM) abnormalities are commonly reported in psychiatric disorders. Whether peripartum insufficiencies in brain oxygenation, known as birth asphyxia, are associated with WM of patients with severe mental disorders is unclear. Objective: To examine the association between birth asphyxia and WM in adult patients with schizophrenia and bipolar disorders (BDs) compared with healthy adults. Design, setting, and participants: In this case-control study, all individuals participating in the ongoing Thematically Organized Psychosis project were linked to the Medical Birth Registry of Norway (MBRN), where a subset of 271 patients (case group) and 529 healthy individuals (control group) had undergone diffusion-weighted imaging (DWI). Statistical analyses were performed from June 16, 2020, to March 9, 2021. Exposures: Birth asphyxia was defined based on measures from standardized reporting at birth in the MBRN. Main outcomes and measures: Associations between birth asphyxia and WM regions of interest diffusion metrics, ie, fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD), were compared between groups using analysis of covariance, adjusted for age, age squared, and sex. Results: Of the 850 adults included in the study, 271 were in the case group (140 [52%] female individuals; mean [SD] age, 28.64 [7.43] years) and 579 were in the control group (245 [42%] female individuals; mean [SD] age, 33.54 [8.31] years). Birth asphyxia measures were identified in 15% to 16% of participants, independent of group. The posterior limb of the internal capsule (PLIC) showed a significant diagnostic group × birth asphyxia interaction (F(1, 843) = 11.46; P = .001), reflecting a stronger association between birth asphyxia and FA in the case group than the control group. RD, but not AD, also displayed a significant diagnostic group × birth asphyxia interaction (F(1, 843) = 9.28; P = .002) in the PLIC, with higher values in patients with birth asphyxia and similar effect sizes as observed for FA. Conclusions and relevance: In this case-control study, abnormalities in the PLIC of adult patients with birth asphyxia may suggest a greater susceptibility to hypoxia in patients with severe mental illness, which could lead to myelin damage or impeded brain development. Echoing recent early-stage schizophrenia studies, abnormalities of the PLIC are relevant to psychiatric disorders, as the PLIC contains important WM brain pathways associated with language, cognitive function, and sensory function, which are impaired in schizophrenia and BDs.

• Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid & Andreou, Dimitrios [Show all 31 contributors for this article] (2021). Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain, Behavior, and Immunity. ISSN 0889-1591. 99, p. 299–306. doi: 10.1016/j.bbi.2021.10.017. Full text in Research Archive Show summary

  Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic lipid ratios have been shown to correlate with circulating levels of inflammatory biomarkers in SMI. It is, however, not yet known if increased systemic cholesterol load leads to inflammasome activation in these patients. Methods We tested the hypothesis that patients with SCZ and BD display higher circulating levels compared to healthy individuals of key members of the IL-18 system using a large patient cohort (n = 1632; including 737 SCZ and 895 BD), and healthy controls (CTRL; n = 1070). In addition, we assessed associations with coronary artery disease risk factors in SMI, focusing on relevant inflammasome-related, neuroendocrine, and lipid markers. Results We report higher baseline levels of circulating IL-18 system components (IL-18, IL-18BPA, IL-18R1), and increased expression of inflammasome-related genes (NLRP3 and NLRC4) in the blood of patients relative to CTRL. We demonstrate a cholesterol dyslipidemia pattern in psychotic disorders, and report correlations between levels of blood cholesterol types and the expression of inflammasome system elements in SMI. Conclusions Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.

• de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor & Jansen, Iris E. [Show all 51 contributors for this article] (2021). Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications. ISSN 2041-1723. 12, p. 1–16. doi: 10.1038/s41467-021-22491-8. Full text in Research Archive Show summary

  Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease.

• Haan, Elis; Sallis, Hannah M.; Zuccolo, Luisa; Labrecque, Jeremy; Ystrøm, Eivind & Reichborn-Kjennerud, Ted [Show all 9 contributors for this article] (2021). Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses. Addiction. ISSN 0965-2140. doi: 10.1111/add.15746. Full text in Research Archive
• Kvam, Tor-Morten; Stewart, Lowan H.; Blomkvist, Andreas Wahl & Andreassen, Ole A. (2021). Ketamine for depression – evidence and proposals for practice. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(15), p. 1–5. doi: 10.4045/tidsskr.21.0480.
• Nerland, Stener; Jørgensen, Kjetil Nordbø; Nordhøy, Wibeke; Maximov, Ivan; Bugge, Robin Antony Birkeland & Westlye, Lars Tjelta [Show all 9 contributors for this article] (2021). Multisite reproducibility and test-retest reliability of the T1w/T2w-ratio: A comparison of processing methods. NeuroImage. ISSN 1053-8119. 245. doi: 10.1016/j.neuroimage.2021.118709. Full text in Research Archive
• Hilland, Eva; Johannessen, Cecilie Haggag; Jonassen, Rune; Alnæs, Dag; Jørgensen, Kjetil Nordbø & Barth, Claudia [Show all 17 contributors for this article] (2021). Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study. NeuroImage: Clinical. ISSN 2213-1582. 33. doi: 10.1016/j.nicl.2021.102881. Full text in Research Archive
• Tahmasian, Masoud; Aleman, André; Andreassen, Ole; Arab, Zahra; Baillet, Marion & Benedetti, Francesco [Show all 77 contributors for this article] (2021). ENIGMA-Sleep: Challenges, opportunities, and the road map. Journal of Sleep Research. ISSN 0962-1105. 30(6), p. 1–20. doi: 10.1111/jsr.13347.
• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine V.; Steen, Nils Eiel; Andreassen, Ole A. & Steen, Vidar M. [Show all 7 contributors for this article] (2021). Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.723158. Full text in Research Archive
• Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Kaale, Anett & Wirgenes, Katrine V. [Show all 10 contributors for this article] (2021). Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health. European Journal of Human Genetics. ISSN 1018-4813. p. 1–9. doi: 10.1038/s41431-021-00966-y. Full text in Research Archive
• Lin, Yan; Maihofer, Adam X.; Stapp, Emma; Ritchey, Megan; Alliey-Rodriguez, Ney & Anand, Amit [Show all 53 contributors for this article] (2021). Clinical Predictors of Non‐Response to Lithium Treatment in The Pharmacogenomics of Bipolar Disorder (PGBD) Study. Bipolar Disorders. ISSN 1398-5647. 23(8), p. 821–831. doi: 10.1111/bdi.13078. Full text in Research Archive Show summary

  Background Lithium is regarded as a first-line treatment for bipolar disorder (BD), but partial response and non-response commonly occurs. There exists a need to identify lithium non-responders prior to initiating treatment. The Pharmacogenomics of Bipolar Disorder (PGBD) Study was designed to identify predictors of lithium response. Methods The PGBD Study was an eleven site prospective trial of lithium treatment in bipolar I disorder. Subjects were stabilized on lithium monotherapy over 4 months and gradually discontinued from all other psychotropic medications. After ensuring a sustained clinical remission (defined by a score of ≤3 on the CGI for 4 weeks) had been achieved, subjects were followed for up to 2 years to monitor clinical response. Cox proportional hazard models were used to examine the relationship between clinical measures and time until failure to remit or relapse. Results A total of 345 individuals were enrolled into the study and included in the analysis. Of these, 101 subjects failed to remit or relapsed, 88 achieved remission and continued to study completion, and 156 were terminated from the study for other reasons. Significant clinical predictors of treatment failure (p < 0.05) included baseline anxiety symptoms, functional impairments, negative life events and lifetime clinical features such as a history of migraine, suicidal ideation/attempts, and mixed episodes, as well as a chronic course of illness. Conclusions In this PGBD Study of lithium response, several clinical features were found to be associated with failure to respond to lithium. Future validation is needed to confirm these clinical predictors of treatment failure and their use clinically to distinguish who will do well on lithium before starting pharmacotherapy.

• Abé, Christoph; Ching, Christopher R.K.; Liberg, Benny; Lebedev, Alexander V.; Agartz, Ingrid & Akudjedu, Theophilus N. [Show all 72 contributors for this article] (2021). Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.09.008. Full text in Research Archive
• Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Show all 24 contributors for this article] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), p. 1751–1760. doi: 10.1093/schbul/sbab049. Full text in Research Archive
• Bell, Christina; Tesli, Natalia; Gurholt, Tiril Pedersen; Rokicki, Jaroslav; Hjell, Gabriela & Fischer-Vieler, Thomas [Show all 13 contributors for this article] (2021). Associations between amygdala nuclei volumes, psychosis, psychopathy, and violent offending. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 319. doi: 10.1016/j.pscychresns.2021.111416. Full text in Research Archive
• Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar; Wedervang-Resell, Kirsten & Nerland, Stener [Show all 25 contributors for this article] (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. ISSN 0033-2917. p. 1–10. doi: 10.1017/S0033291721003056. Full text in Research Archive
• Shadrin, Alexey A.; Kaufmann, Tobias; van der Meer, Dennis; Palmer, Clare E.; Makowski, Carolina & Loughnan, Robert [Show all 22 contributors for this article] (2021). Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. NeuroImage. ISSN 1053-8119. 244, p. 1–8. doi: 10.1016/j.neuroimage.2021.118603. Full text in Research Archive
• Tesli, Natalia; Rokicki, Jaroslav; Maximov, Ivan; Bell, Christina; Hjell, Gabriela & Gurholt, Tiril Pedersen [Show all 17 contributors for this article] (2021). White Matter Matters: Unraveling Violence in Psychosis and Psychopathy. Schizophrenia Bulletin Open. ISSN 2632-7899. 2(1). doi: 10.1093/schizbullopen/sgab026. Full text in Research Archive
• Bigseth, Therese Torgersen; Engh, John; Egeland, Jens; Andersen, Eivind; Andreassen, Ole & Bang-Kittilsen, Gry [Show all 15 contributors for this article] (2021). Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms. BMC Psychiatry. ISSN 1471-244X. 21(1), p. 1–10. doi: 10.1186/s12888-021-03522-6. Full text in Research Archive
• Monereo-Sánchez, Jennifer; Luykx, Jurjen J.; Pinzón-Espinosa, Justo; Richard, Geneviève; Motazedi, Ehsan & Westlye, Lars Tjelta [Show all 8 contributors for this article] (2021). Diphtheria And Tetanus Vaccination History Is Associated With Lower Odds of COVID-19 Hospitalization. Frontiers in Immunology. ISSN 1664-3224. 12, p. 1–7. doi: 10.3389/fimmu.2021.749264. Full text in Research Archive
• Szabo, Attila; Akkouh, Ibrahim A.; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy & Heine, Vivi [Show all 10 contributors for this article] (2021). A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01681-4. Full text in Research Archive
• Andreou, Dimitrios; Jørgensen, Kjetil Nordbø; Nerland, Stener; Smelror, Runar; Wedervang-Resell, Kirsten & Johannessen, Cecilie Haggag [Show all 11 contributors for this article] (2021). Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex. Journal of Psychiatric Research. ISSN 0022-3956. 144, p. 255–261. doi: 10.1016/j.jpsychires.2021.10.031. Full text in Research Archive
• Beck, Dani; de Lange, Ann-Marie G.; Pedersen, Mads L.; Alnæs, Dag; Maximov, Ivan & Voldsbekk, Irene [Show all 18 contributors for this article] (2021). Cardiometabolic risk factors associated with brain age and accelerate brain ageing. Human Brain Mapping. ISSN 1065-9471. p. 1–21. doi: 10.1002/hbm.25680. Full text in Research Archive
• Jiang, Wenhao; Rootes-Murdy, Kelly; Chen, Jiayu; Bizzozero, Nora I.Perrone-; Calhoun, Vince D. & van Erp, Theo G.M. [Show all 16 contributors for this article] (2021). Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia. Psychiatry Research. ISSN 0165-1781. 306. doi: 10.1016/j.psychres.2021.114237.
• Pihlstrøm, Lasse; Fan, Chun Chieh; Frei, Oleksandr; Tan, Manuela; Karunamuni, Roshan A. & Blauwendraat, Cornelis [Show all 12 contributors for this article] (2021). Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score. Movement Disorders. ISSN 0885-3185. doi: 10.1002/mds.28808. Full text in Research Archive
• Lie, Selma; Bulik, Cynthia M.; Andreassen, Ole; Rø, Øyvind & Bang, Lasse (2021). Stressful life events among individuals with a history of eating disorders: a case-control comparison. BMC Psychiatry. ISSN 1471-244X. 21, p. 1–12. doi: 10.1186/s12888-021-03499-2. Full text in Research Archive
• Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen & Corfield, Elizabeth [Show all 12 contributors for this article] (2021). Early manifestations of genetic risk for neurodevelopmental disorders. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. p. 1–10. doi: 10.1111/jcpp.13528. Full text in Research Archive
• Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon & Lin, Aihua [Show all 14 contributors for this article] (2021). Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. Addiction. ISSN 0965-2140. doi: 10.1111/add.15680. Full text in Research Archive
• Monereo-Sánchez, Jennifer; Schram, Miranda T.; Frei, Oleksandr; O'Connell, Kevin Sean; Shadrin, Alexey & Smeland, Olav Bjerkehagen [Show all 11 contributors for this article] (2021). Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain. Frontiers in Neuroscience. ISSN 1662-4548. 15, p. 1–9. doi: 10.3389/fnins.2021.653130. Full text in Research Archive
• O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Cheng, Weiqiu [Show all 16 contributors for this article] (2021). Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.07.007. Full text in Research Archive
• Birkenæs, Viktoria; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Høegh, Margrethe Collier; Haram, Marit & Werner, Maren Caroline Frogner [Show all 14 contributors for this article] (2021). Telomeres are shorter and associated with number of suicide attempts in affective disorders. Journal of Affective Disorders. ISSN 0165-0327. 295, p. 1032–1039. doi: 10.1016/j.jad.2021.08.135.
• Gutman, Boris A.; van Erp, Theo G.M.; Alpert, Kathryn I.; Ching, Christopher; Isaev, Dmitry & Ragothaman, Anjani [Show all 84 contributors for this article] (2021). A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25625. Full text in Research Archive
• Haan, E; Sallis, H; Ystrøm, Eivind; Njølstad, Pål Rasmus; Andreassen, Ole & Reichborn-Kjennerud, Ted [Show all 9 contributors for this article] (2021). Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring. Alcoholism: Clinical and Experimental Research. ISSN 0145-6008. 45(10), p. 2090–2102. doi: 10.1111/acer.14692. Full text in Research Archive
• Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Show all 13 contributors for this article] (2021). Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Translational Psychiatry. ISSN 2158-3188. 11:466, p. 1–10. doi: 10.1038/s41398-021-01576-4. Full text in Research Archive
• Jalbrzikowski, Maria; Hayes, Rebecca A.; Wood, Stephen J.; Dorte, Nordholm; Zhou, Juan H & Fusar-Poli, Paolo [Show all 51 contributors for this article] (2021). Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis. JAMA psychiatry. ISSN 2168-6238. 78(7), p. 753–766. doi: 10.1001/jamapsychiatry.2021.0638.
• Sønderby, Ida Elken; Ching, Christopher R. K.; Thomopoulos, Sophia I.; van der Meer, Dennis; Sun, Daqiang & Villalon-Reina, Julio E. [Show all 52 contributors for this article] (2021). Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25354. Full text in Research Archive
• Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram & Holland, Dominic [Show all 59 contributors for this article] (2021). A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics. ISSN 1061-4036. 53, p. 1276–1282. doi: 10.1038/s41588-021-00921-z.
• Engh, John; Ueland, Thor; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål & Boye, Birgitte [Show all 27 contributors for this article] (2021). Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study. Schizophrenia Bulletin. ISSN 0586-7614. p. 1–10. doi: 10.1093/schbul/sbab106.
• Polushina, Tatiana; Banerjee, Niladri; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas & Lundervold, Astri J. [Show all 13 contributors for this article] (2021). Identification of pleiotropy at the gene level between psychiatric disorders and related traits. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01530-4. Full text in Research Archive
• Elvsåshagen, Torbjørn; Shadrin, Alexey; Frei, Oleksandr; van der Meer, Dennis; Bahrami, Shahram & Kumar, Vinod J. [Show all 10 contributors for this article] (2021). The genetic architecture of the human thalamus and its overlap with ten common brain disorders. Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23175-z. Full text in Research Archive
• Yuan, Xiuxia; Wang, Yunpeng; Li, Xue; Jiang, Jiajun; Kang, Yulin & Pang, Lijuan [Show all 13 contributors for this article] (2021). Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study. Translational Psychiatry. ISSN 2158-3188. 11, p. 1–9. doi: 10.1038/s41398-021-01531-3. Full text in Research Archive Show summary

  Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via the gut-brain axis. However, its role in the antipsychotic treatment response is unclear. Here, we present a 24-week follow-up study to identify gut microbial biomarkers for SCH diagnosis and treatment response, using a sample of 107 first-episode, drug-naïve SCH patients, and 107 healthy controls (HCs). We collected biological samples at baseline (all participants) and follow-up time points after risperidone treatment (SCH patients). Treatment response was assessed using the Positive and Negative Symptoms Scale total (PANSS-T) score. False discovery rate was used to correct for multiple testing. We found that SCH patients showed lower α-diversity (the Shannon and Simpson’s indices) compared to HCs at baseline (p = 1.21 × 10−9, 1.23 × 10−8, respectively). We also found a significant difference in β-diversity between SCH patients and HCs (p = 0.001). At baseline, using microbes that showed different abundance between patients and controls as predictors, a prediction model can distinguish patients from HCs with an area under the curve (AUC) of 0.867. In SCH patients, after 24 weeks of risperidone treatment, we observed an increase of α-diversity toward the basal level of HCs. At the genus level, we observed decreased abundance of Lachnoclostridium (p = 0.019) and increased abundance Romboutsia (p = 0.067). Moreover, the treatment response in SCH patients was significantly associated with the basal levels of Lachnoclostridium and Romboutsia (p = 0.005 and 0.006, respectively). Our results suggest that SCH patients may present characteristic microbiota, and certain microbiota biomarkers may predict treatment response in this patient population.

• Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun Chieh; Shadrin, Alexey & Smeland, Olav Bjerkehagen [Show all 8 contributors for this article] (2021). The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity. Genetics. ISSN 0016-6731. 217(3), p. 1–21. doi: 10.1093/genetics/iyaa046.
• Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, p. 999–1008. doi: 10.1007/s40263-021-00847-4. Full text in Research Archive
• Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean & Smeland, Olav Bjerkehagen [Show all 10 contributors for this article] (2021). Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors. Translational Psychiatry. ISSN 2158-3188. 11(1), p. 1–13. doi: 10.1038/s41398-021-01466-9. Full text in Research Archive
• Siafarikas, Nikias Ioannis; Alnæs, Dag; Monereo Sanchez, Jennifer; Lund, Martina J.; Selbæk, Geir & Korsnes, Maria Stylianou [Show all 13 contributors for this article] (2021). Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer's disease with dementia. International Psychogeriatrics. ISSN 1041-6102. 33(11), p. 1217–1228. doi: 10.1017/S1041610221000934.
• Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Show all 76 contributors for this article] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Full text in Research Archive
• Akkouh, Ibrahim; Hribkova, Hana; Grabiec, Marta; Budinska, Eva; Szabo, Attila & Kasparek, Tomas [Show all 9 contributors for this article] (2021). Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response. Schizophrenia Bulletin. ISSN 0586-7614. doi: 10.1093/schbul/sbab092. Full text in Research Archive
• Reponen, Elina Johanna; Tesli, Martin Steen; Dieset, Ingrid; Steen, Nils Eiel; Vedal, Trude Seselie Jahr & Szabo, Attila [Show all 12 contributors for this article] (2021). Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.623192. Full text in Research Archive
• Andreou, Dimitrios; Jørgensen, Kjetil Nordbø; Nerland, Stener; Engen, Kristine; Yolken, Robert H. & Andreassen, Ole [Show all 7 contributors for this article] (2021). Cytomegalovirus infection associated with smaller dentate gyrus in men with severe mental illness. Brain, Behavior, and Immunity. ISSN 0889-1591. 96, p. 54–62. doi: 10.1016/j.bbi.2021.05.009. Full text in Research Archive
• Mattingsdal, Morten; Ebenesersdóttir, Sigríður Sunna; Moore, Kristjan H. S.; Andreassen, Ole Andreas; Hansen, Thomas F. & Werge, Thomas [Show all 12 contributors for this article] (2021). The genetic structure of Norway. European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/s41431-021-00899-6. Full text in Research Archive
• DeMichele-Sweet, Mary Ann A.; Klei, Lambertus; Creese, Byron; Harwood, Janet C.; Weamer, Elise A. & McClain, Lora [Show all 44 contributors for this article] (2021). Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Molecular Psychiatry. ISSN 1359-4184. 26, p. 5797–5811. doi: 10.1038/s41380-021-01152-8.
• de Lange, Ann-Marie Glasø; Kaufmann, Tobias; Quintana, Daniel; Winterton, Adriano; Andreassen, Ole Andreas & Westlye, Lars Tjelta [Show all 7 contributors for this article] (2021). Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study. Behavioural Brain Research. ISSN 0166-4328. doi: 10.1016/j.bbr.2021.113510. Full text in Research Archive
• O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia & Smeland, Olav Bjerkehagen [Show all 13 contributors for this article] (2021). Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank. Psychological Medicine. ISSN 0033-2917. p. 1–11. doi: 10.1017/S0033291721000179. Full text in Research Archive
• Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A. & O'Connell, Kevin Sean [Show all 14 contributors for this article] (2021). Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01527-z. Full text in Research Archive
• Vaskinn, Anja; Sundet, Kjetil; Melle, Ingrid; Andreassen, Ole A. & Friis, Svein (2021). The factor structure of social cognition in schizophrenia: Weak evidence for separable domains. Schizophrenia Research: Cognition. ISSN 2215-0013. 26, p. 1–4. doi: 10.1016/j.scog.2021.100208. Full text in Research Archive Show summary

  This study examined the factor structure of social cognition in a Norwegian sample of individuals diagnosed with schizophrenia (n = 83). Eight variables from three social cognitive tests from three theoretical domains were included: emotion processing, social perception and theory of mind. Factor analysis with maximum likelihood extraction and oblique rotation resulted in two factors using Kaiser's criterion. Although the two-factor model had better fit than a unifactorial model, it did not represent the data well. Two social cognitive variables did not load on either factor. The two extracted factors did not correspond to an expected distinction between low and high level of processing or between affective and cognitive processes. A non-negligible number of nonredundant residuals between observed and computed correlations suggested poor model fit. In conclusion, this study failed to identify separable dimensions of social cognition in spite of including measures from different theoretical domains.

• Wolfers, Thomas; Rokicki, Jaroslav; Alnæs, Dag; Berthet, Pierre; Agartz, Ingrid & Kia, Seyed Mostafa [Show all 14 contributors for this article] (2021). Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder. Human Brain Mapping. ISSN 1065-9471. 42(8), p. 2546–2555. doi: 10.1002/hbm.25386. Full text in Research Archive
• Chen, Jiayu; Li, Xiang; Calhoun, Vince D.; Turner, Jessica A.; van Erp, Theo G.M. & Wang, Lei [Show all 16 contributors for this article] (2021). Sparse deep neural networks on imaging genetics for schizophrenia case–control classification. Human Brain Mapping. ISSN 1065-9471. 42(8), p. 2556–2568. doi: 10.1002/hbm.25387. Full text in Research Archive
• Aas, Monica; Ueland, Torill; Mørch, Ragni Helene; Laskemoen, Jannicke Fjæra; Lunding, Synve Hoffart & Reponen, Elina Johanna [Show all 11 contributors for this article] (2021). Physical activity and childhood trauma experiences in patients with schizophrenia or bipolar disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 22(8), p. 637–645. doi: 10.1080/15622975.2021.1907707. Full text in Research Archive
• Lie, Selma; Bulik, Cynthia M.; Andreassen, Ole A.; Rø, Øyvind & Bang, Lasse (2021). The association between bullying and eating disorders: A case–control study. International Journal of Eating Disorders. ISSN 0276-3478. 54(8), p. 1405–1414. doi: 10.1002/eat.23522. Full text in Research Archive
• Lunding, Synve Hoffart; Simonsen, Carmen Elisabeth; Aas, Monica; Rødevand, Linn ; Werner, Maren Caroline Frogner & Laskemoen, Jannicke Fjæra [Show all 13 contributors for this article] (2021). Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control. European psychiatry. ISSN 0924-9338. 64(1). doi: 10.1192/j.eurpsy.2021.14. Full text in Research Archive
• Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Show all 20 contributors for this article] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), p. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Full text in Research Archive
• Norbom, Linn Christin Bonaventure; Ferschmann, Lia; Parker, Nadine; Agartz, Ingrid; Andreassen, Ole Andreas & Paus, Tomas [Show all 8 contributors for this article] (2021). New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro- and microstructural MRI findings. Progress in Neurobiology. ISSN 0301-0082. 204, p. 1–19. doi: 10.1016/j.pneurobio.2021.102109. Full text in Research Archive
• Puppo, Francesca; Sadegh, Sanaz; Trujillo, Cleber A.; Thunemann, Martin; Campbell, Evan P. & Vandenberghe, Matthieu [Show all 17 contributors for this article] (2021). All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 15. doi: 10.3389/fncel.2021.671549. Full text in Research Archive
• Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H. & van der Meer, Dennis [Show all 17 contributors for this article] (2021). Population-based body–brain mapping links brain morphology with anthropometrics and body composition. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01414-7. Full text in Research Archive
• Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia & Hughes, Timothy [Show all 10 contributors for this article] (2021). Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-021-01164-4. Full text in Research Archive
• Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis & Bettella, Francesco [Show all 11 contributors for this article] (2021). Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study. The Pharmacogenomics Journal. ISSN 1470-269X. 21, p. 574–585 . doi: 10.1038/s41397-021-00234-8.
• Smelror, Runar; Johannessen, Cecilie Haggag; Wedervang-Resell, Kirsten; Jørgensen, Kjetil Nordbø; Barth, Claudia & Andreou, Dimitrios [Show all 11 contributors for this article] (2021). Cognitive Impairment Profile in Adolescent Early-Onset Psychosis Usingthe MATRICS Battery: Age and Sex Effects. Neuropsychology. ISSN 0894-4105. 35(3), p. 300–309. doi: 10.1037/neu0000723.
• Andreou, Dimitrios; Jørgensen, Kjetil Nordbø; Bakke, Laura A Wortinger; Engen, Kristine; Vaskinn, Anja & Ueland, Torill [Show all 9 contributors for this article] (2021). Cytomegalovirus infection and IQ in patients with severe mental illness and healthy individuals. Psychiatry Research. ISSN 0165-1781. doi: 10.1016/j.psychres.2021.113929. Full text in Research Archive Show summary

  Cytomegalovirus (CMV) infection in immunocompetent adults is usually asymptomatic, but results in lifelong latency. Infection occurring congenitally or in immunodeficiency can lead to cognitive impairment. We aimed to investigate the associations between CMV exposure and intelligence quotient (IQ) in patients with schizophrenia spectrum disorders (SZS), bipolar spectrum disorders (BDS) and healthy controls (HC). CMV immunoglobulin G antibody concentrations were measured by immunoassay and expressed as dichotomous measures (seropositive/CMV+ vs. seronegative/CMV-). Based on a significant CMV-by-diagnosis-by-sex interaction on IQ, we investigated main and interaction effects of CMV and sex on IQ in each diagnostic category. Significant CMV-by-sex interactions were found in patient groups. In SZS, CMV+ female patients (n = 50) had significantly lower IQ than CMV- female patients (n = 33), whereas CMV+ (n = 48) and CMV- (n = 45) male patients did not differ in IQ. In BDS, CMV+ (n = 49) and CMV- (n = 37) female patients did not differ in IQ, whereas CMV+ male patients (n = 33) had significantly higher IQ than CMV- male patients (n = 32). Among HC, CMV+ (n = 138) and CMV- (n = 118) male participants as well as CMV+ (n = 125) and CMV- (n = 93) female participants did not differ in IQ. Our findings suggest that CMV exposure may affect IQ in patients with severe mental illness but not HC.

• Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco & Krull, Florian [Show all 15 contributors for this article] (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour. ISSN 2397-3374. p. 1–9. doi: 10.1038/s41562-020-01031-2.
• Ditmars, Hillary L.; Logue, Mark W.; Toomey, Rosemary; McKenzie, Ruth E.; Franz, Carol E. & Panizzon, Matthew S. [Show all 27 contributors for this article] (2021). Associations between depression and cardiometabolic health: A 27-year longitudinal study. Psychological Medicine. ISSN 0033-2917. p. 1–11. doi: 10.1017/S003329172000505X. Full text in Research Archive
• Kessing, Lars Vedel; Gonzalez-Pinto, Ana; Fagiolini, Andrea; Bechdolf, Andreas; Reif, Andreas & Yildiz, Ayşegül [Show all 29 contributors for this article] (2021). DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis – A narrative review from the ECNP bipolar disorders network. European Neuropsychopharmacology. ISSN 0924-977X. p. 1–8. doi: 10.1016/j.euroneuro.2021.01.097.
• Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01313-x. Full text in Research Archive Show summary

  Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Using independent component analysis, we decomposed self-report mental health questionnaires from 136,678 healthy individuals of the UK Biobank, excluding data from individuals with a diagnosed neurological or psychiatric disorder, into 13 distinct profiles relevant to mental health, capturing different symptoms as well as social and risk factors underlying reduced mental health. Utilizing genotypes from 117,611 of those individuals with White British ancestry, we performed GWAS for each mental health profile and assessed genetic correlations between these profiles, and between the profiles and common psychiatric disorders and cognitive traits. We found that mental health profiles were genetically correlated with a wide range of psychiatric disorders and cognitive traits, with strongest effects typically observed between a given mental health profile and a disorder for which the profile is common (e.g. depression symptoms and major depressive disorder, or psychosis and schizophrenia). Strikingly, although the profiles were phenotypically uncorrelated, many of them were genetically correlated with each other. This study provides evidence that statistically independent mental health profiles partly share genetic underpinnings and show genetic overlap with psychiatric disorders, suggesting that shared genetics across psychiatric disorders cannot be exclusively attributed to the known overlapping symptomatology between the disorders.

• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2021). Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD). Journal of Autism and Developmental Disorders. ISSN 0162-3257. p. 1–19. doi: 10.1007/s10803-020-04853-1. Full text in Research Archive Show summary

  Pragmatic language impairments are common in neurodevelopmental disorders, especially in autism spectrum disorder (ASD). The relationship between structural language skills and pragmatic competence in children with autistic symptoms, however, is largely unknown. We investigated this relationship based on the Children’s Communication Checklist-2 and early language delay among children (N = 177, 19% females) clinically evaluated for ASD, differentiated into ASD (n = 148) and non-ASD (n = 29). Structural language deficits were common and associated with reduced pragmatic competence in both groups. Pragmatic language impairments were most profound in children with ASD. Early language delay and structural language deficits were less common in females. Our findings suggest that assessment of structural language skills should be included in the evaluation of children with suspected ASD.

• Wortinger, Laura Anne; Jørgensen, Kjetil Nordbø; Barth, Claudia; Nerland, Stener; Smelror, Runar Elle & Vaskinn, Anja [Show all 9 contributors for this article] (2021). Significant association between intracranial volume and verbal intellectual abilities in patients with schizophrenia and a history of birth asphyxia. Psychological Medicine. ISSN 0033-2917. p. 1–10. doi: 10.1017/S0033291721000489. Full text in Research Archive
• Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas & Djurovic, Srdjan [Show all 7 contributors for this article] (2021). Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia. Brain, Behavior, and Immunity. ISSN 0889-1591. doi: 10.1016/j.bbi.2021.01.037. Full text in Research Archive
• Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin; Corfield, Elizabeth & Ayorech, Ziada [Show all 15 contributors for this article] (2021). Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population. Schizophrenia Bulletin. ISSN 0586-7614. 47(4), p. 1179–1189. doi: 10.1093/schbul/sbaa193. Full text in Research Archive
• Wisting, Line Norøm; Johnson, Sverre Urnes; Bulik, Cynthia M.; Andreassen, Ole Andreas; Rø, Øyvind & Bang, Lasse (2021). Psychometric properties of the Norwegian version of the Patient Health Questionnaire-9 (PHQ-9) in a large female sample of adults with and without eating disorders. BMC Psychiatry. ISSN 1471-244X. 21:6, p. 1–11. doi: 10.1186/s12888-020-03013-0. Full text in Research Archive
• Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman & Shadrin, Alexey A. [Show all 18 contributors for this article] (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-020-01142-4. Full text in Research Archive Show summary

  Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.

• Mufford, Mary S; van der Meer, Dennis; Andreassen, Ole Andreas; Ramesar, Raj; Stein, Dan J. & Dalvie, Shareefa (2021). A review of systems biology research of anxiety disorders. Revista Brasileira de Psiquiatria. ISSN 1516-4446. 43(4), p. 414–423. doi: 10.1590/1516-4446-2020-1090. Full text in Research Archive
• Reis de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S. & Akkouh, Ibrahim [Show all 10 contributors for this article] (2021). Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder. Cells. ISSN 2073-4409. 10(2). doi: 10.3390/cells10020209. Full text in Research Archive
• Bigseth, Therese Torgersen; Fredriksen, Mats; Egeland, Jens; Andersen, Eivind; Andreassen, Ole Andreas & Bang-Kittilsen, Gry [Show all 15 contributors for this article] (2021). Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia: A case-control study. Schizophrenia Research. ISSN 0920-9964. 228, p. 190–192. doi: 10.1016/j.schres.2020.11.051.
• Barth, Claudia; Nerland, Stener; de Lange, Ann-Marie Glasø; Wortinger, Laura Anne ; Hilland, Eva & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2021). In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders. Schizophrenia Bulletin. ISSN 0586-7614. 47(5), p. 1431–1441. doi: 10.1093/schbul/sbaa192. Full text in Research Archive
• Solé-Navais, Pol; Bacelis, Jonas; Helgeland, Øyvind; Modzelewska, Dominika; Vaudel, Marc & Flatley, Christopher [Show all 12 contributors for this article] (2020). Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios. Human Molecular Genetics. ISSN 0964-6906. 29(23), p. 3845–3858. doi: 10.1093/hmg/ddaa255. Full text in Research Archive
• Bryois, Julien; Skene, Nathan G.; Hansen, Thomas Folkmann; Kogelman, Lisette J.A.; Watson, Hunna J. & Liu, Zijing [Show all 50 contributors for this article] (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics. ISSN 1061-4036. 52, p. 482–493. doi: 10.1038/s41588-020-0610-9. Full text in Research Archive
• Sæther, Linn Sofie; Roelfs, Daniël Thomas Heimen; Moberget, Torgeir; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn & Jönsson, Erik Gunnar [Show all 7 contributors for this article] (2020). Exploring neurophysiological markers of visual perspective taking: Methodological considerations. International Journal of Psychophysiology. ISSN 0167-8760. doi: 10.1016/j.ijpsycho.2020.12.006. Full text in Research Archive Show summary

  Rationale: For visual perspective taking (VPT) using the avatar task, examinations of neural processes using event related potentials (ERP) indicate a distinction between an early posterior perspective calculation process (P3) and a later frontal process (LFSW) managing perspective conflict. While it is unknown if these neural processes are affected in clinical populations, it is unclear if the avatar task can be applied to this group, due to the long duration and sensitivity to data loss. Thus, we performed a methodological study of the avatar task, testing the feasibility of a shortened experimental paradigm. Objective: To investigate whether previously reported behavioural and ERP effects in the avatar task can also be seen if analysing all trials (matching/non-matching) jointly, and whether they remain robust if only a subset of the data is analysed. Method: Healthy individuals (n = 20) completed the avatar task with ERP measurement. ERP components (P3, LFSW) and behavioural data were investigated by A) comparing use of only matching trials (n = 384) versus all trials (n = 768), and B) examining if reduced duration of assessment, by analysing only a subset of the data, impacts ERP findings. Results: We observed minimal differences when analysing data from only matching trial types compared to all trial types. Further, ERP amplitudes and latency findings were replicated when analysing only a subset of the data. Conclusions: The duration of the avatar task can be reduced to avoid long testing times, thus making it better suited for use in clinical populations.

• Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides & Beck, Dani [Show all 18 contributors for this article] (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117302. Full text in Research Archive
• Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji & Akudjedu, Theophilus N. [Show all 50 contributors for this article] (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25204. Full text in Research Archive
• Tao, Qi; Miao, Yun; Li, Huihui; Yuan, Xiuxia; Huang, Xufeng & Wang, Yunpeng [Show all 10 contributors for this article] (2020). Insulin Resistance and Oxidative Stress: In Relation to Cognitive Function and Psychopathology in Drug-Naïve, First-Episode Drug-Free Schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. doi: 10.3389/fpsyt.2020.537280. Full text in Research Archive
• Schwarz, Emanuel; Alnæs, Dag; Andreassen, Ole Andreas; Cao, Han; Chen, Junfang & Degenhardt, Franziska [Show all 27 contributors for this article] (2020). Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-020-00915-z. Full text in Research Archive
• Lind, Mackenzie; Brick, Leslie A; Gehrman, Philip R; Gelaye, Bizu; Maihofer, Adam X. & Nievergelt, Caroline M. [Show all 55 contributors for this article] (2020). Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes. Sleep. ISSN 0161-8105. doi: 10.1093/sleep/zsz257.
• Kochunov, Peter; Hong, Elliot; Dennis, Emily L; Morey, Rajendra A.; Tate, David F. & Logue, Mark W. [Show all 31 contributors for this article] (2020). ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.24998. Full text in Research Archive
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun C.; Eeles, Rosalind A; Easton, Douglas F & Kote-Jarai, ZSofia [Show all 58 contributors for this article] (2020). The effect of sample size on polygenic hazard models for prostate cancer. European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/s41431-020-0664-2.
• Kamitaki, Nolan; Sekar, Aswin; Handsaker, Robert E; de Rivera,, Heather; Tooley,, Katherine & Morris,, David L. [Show all 50 contributors for this article] (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature. ISSN 0028-0836. doi: 10.1038/s41586-020-2277-x.
• Huynh-Le, Minh-Phuong; Myklebust, Tor Åge; Feng, Christine; Karunamuni, Roshan; Johannesen, Tom Børge & Dale, Anders M [Show all 8 contributors for this article] (2020). Age dependence of modern clinical risk groups for localized prostate cancer-A population-based study. Cancer. ISSN 0008-543X. 126(8), p. 1691–1699. doi: 10.1002/cncr.32702.
• Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Walsh, Eleanor I.; Turner, Emma & Lane, J. Athene [Show all 50 contributors for this article] (2020). A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data. Cancer Epidemiology, Biomarkers and Prevention. ISSN 1055-9965. 29(9), p. 1731–1738. doi: 10.1158/1055-9965.Epi-19-1527.
• Holleran, Laurena; Kelly, Sinead; Alloza, Clara; Agartz, Ingrid; Andreassen, Ole Andreas & Arango, Celso [Show all 45 contributors for this article] (2020). The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium. American Journal of Psychiatry. ISSN 0002-953X. doi: 10.1176/appi.ajp.2019.19030225.
• Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A. & Smeland, Olav Bjerkehagen [Show all 10 contributors for this article] (2020). Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. PLoS Genetics. ISSN 1553-7390. doi: 10.1371/journal.pgen.1008612. Full text in Research Archive
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang & Li, Shuo [Show all 51 contributors for this article] (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-18367-y. Full text in Research Archive
• Han, Laura KM; Dinga, Richard; Hahn, Tim; Ching, Christopher R. K.; Eyler, Lisa T. & Aftanas, Lyubomir [Show all 50 contributors for this article] (2020). Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-020-0754-0. Full text in Research Archive
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita & Hibar, DP [Show all 50 contributors for this article] (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484). doi: 10.1126/science.aay6690. Full text in Research Archive
• Delfin, Carl Mikael; Reckless, Greg; Bolstad, Ingeborg; Groote, Inge Rasmus; Andreassen, Ole Andreas & Jensen, Jimmy Kristian (2020). Exploring the effects of an acute dose of antipsychotic medication on motivation-mediated BOLD activity using fMRI and a perceptual decision-making task. Neuroscience. ISSN 0306-4522. 440, p. 146–159. doi: 10.1016/j.neuroscience.2020.05.035.
• de Zwarte, Sonja M. C.; Brouwer, Rachel M; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Silvia & Bearden, Carrie E [Show all 50 contributors for this article] (2020). Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25206. Full text in Research Archive
• Cuellar-Partida, Gabriel; Tung, Joyce Y; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil & Andreassen, Ole Andreas [Show all 51 contributors for this article] (2020). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour. ISSN 2397-3374. doi: 10.1038/s41562-020-00956-y.
• Coleman, Jonathan R.I.; Gaspar, Helena A; Bryois, Julien; Byrne, Enda M; Forstner, Andreas J & Holmans, Peter A [Show all 51 contributors for this article] (2020). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2019.10.015.
• Aas, Monica; Ueland, Torill; Inova, Amina; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder. Frontiers in Psychiatry. ISSN 1664-0640. doi: 10.3389/fpsyt.2020.00391. Full text in Research Archive
• Leu, Costin; Richardson, Tom G.; Kaufmann, Tobias; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta [Show all 9 contributors for this article] (2020). Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population. PLOS ONE. ISSN 1932-6203. 15(4). doi: 10.1371/journal.pone.0232292. Full text in Research Archive
• Bakke, Laura A Wortinger; Engen, Kristine; Barth, Claudia; Andreassen, Ole Andreas; Jørgensen, Kjetil Nordbø & Agartz, Ingrid (2020). Asphyxia at birth affects brain structure in patients on the schizophrenia-bipolar disorder spectrum and healthy participants. Psychological Medicine. ISSN 0033-2917. doi: 10.1017/S0033291720002779. Full text in Research Archive
• Manchia, Mirko; Vieta, Eduard; Smeland, Olav Bjerkehagen; Altimus, Cara; Bechdolf, Andreas & Bellivier, Frank [Show all 29 contributors for this article] (2020). Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action. European Neuropsychopharmacology. ISSN 0924-977X. 36, p. 121–136. doi: 10.1016/j.euroneuro.2020.05.006. Full text in Research Archive
• Shadrin, Alexey A.; Mucha, Sören; Ellinghaus, David; Makarious, Mary B; Blauwendraat, Cornelis & Sreelatha, Ashwin [Show all 36 contributors for this article] (2020). Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease. Movement Disorders. ISSN 0885-3185. doi: 10.1002/mds.28338. Full text in Research Archive
• Ching, Christopher R. K.; Hibar, Derrek P.; Gurholt, Tiril Pedersen; Nunes, Abraham; Thomopoulos, Sophia I. & Abé, Chritsoph [Show all 51 contributors for this article] (2020). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25098. Full text in Research Archive
• Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O`Connell, Kevin & Gani, Osman [Show all 12 contributors for this article] (2020). Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR. Bioinformatics. ISSN 1367-4803. doi: 10.1093/bioinformatics/btaa568. Full text in Research Archive
• Winterton, Adriano; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Improving the precision of intranasal oxytocin research. Nature Human Behaviour. ISSN 2397-3374. p. 1–10. doi: 10.1038/s41562-020-00996-4.
• Leerssen, Jeanne; Blanken, Tessa F.; Pozzi, Elena; Jahanshad, Neda; Aftanas, Lyubomir & Andreassen, Ole Andreas [Show all 53 contributors for this article] (2020). Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group. Translational Psychiatry. ISSN 2158-3188. 10(1). doi: 10.1038/s41398-020-01109-5. Full text in Research Archive
• Haukvik, Unn Kristin H.; Gurholt, Tiril Pedersen; Nerland, Stener; Elvsåshagen, Torbjørn; Akudjedu, Theophilus N. & Alda, Martin [Show all 97 contributors for this article] (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping. ISSN 1065-9471. p. 1–14. doi: 10.1002/hbm.25249. Full text in Research Archive
• Costa, Beatrice; Manzoni, Claudia; Bernal-Quiros, Manual; Kia, Demis A.; Aguilar, Miquel & Alvarez, Ignacio [Show all 50 contributors for this article] (2020). C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts. Neurology. ISSN 0028-3878. 95(24), p. e3288–e3302. doi: 10.1212/WNL.0000000000010914. Full text in Research Archive Show summary

  Objective: We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases. Methods: We evaluated expansions frequency in the entire cohort (n = 1,396; behavioral variant frontotemporal dementia [bvFTD] [n = 800], primary progressive aphasia [PPA] [n = 495], and FTLD-motor neuron disease [MND] [n = 101]). We then focused on the bvFTD and PPA cases and tested for association between expansion status, syndromes, genetic ancestry, and AAO applying statistical tests comprising Fisher exact tests, analysis of variance with Tukey post hoc tests, and logistic and nonlinear mixed-effects model regressions. Results: We found C9orf72 pathogenic expansions in 4% of all cases (56/1,396). Expansion carriers differently distributed across syndromes: 12/101 FTLD-MND (11.9%), 40/800 bvFTD (5%), and 4/495 PPA (0.8%). While addressing population substructure through principal components analysis (PCA), we defined 2 patients groups with Central/Northern (n = 873) and Southern European (n = 523) ancestry. The proportion of expansion carriers was significantly higher in bvFTD compared to PPA (5% vs 0.8% [p = 2.17 × 10-5; odds ratio (OR) 6.4; confidence interval (CI) 2.31-24.99]), as well as in individuals with Central/Northern European compared to Southern European ancestry (4.4% vs 1.8% [p = 1.1 × 10-2; OR 2.5; CI 1.17-5.99]). Pathogenic expansions and Central/Northern European ancestry independently and inversely correlated with AAO. Our prediction model (based on expansions status, genetic ancestry, and AAO) predicted a diagnosis of bvFTD with 64% accuracy. Conclusions: Our results indicate correlation between pathogenic C9orf72 expansions, AAO, PCA-based Central/Northern European ancestry, and a diagnosis of bvFTD, implying complex genetic risk architectures differently underpinning the behavioral and language variant syndromes.

• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Thompson, Wesley K.; Eeles, Rosalind A. & Kote-Jarai, Zsofia [Show all 45 contributors for this article] (2020). African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. International Journal of Cancer. ISSN 0020-7136. doi: 10.1002/ijc.33282.
• Halle, Kari Krizak; Bakke, Øyvind; Djurovic, Srdjan; Bye, Anja; Ryeng, Einar & Wisløff, Ulrik [Show all 8 contributors for this article] (2020). Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models. Scandinavian Journal of Statistics. ISSN 0303-6898. 47(4). doi: 10.1111/sjos.12451. Full text in Research Archive
• Patel, Yash; Parker, Nadine; Shin, Jean; Howard, Derek; French, Leon & Thomopoulos, Sophia I. [Show all 299 contributors for this article] (2020). Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA psychiatry. ISSN 2168-6238. 78(1), p. 47–63. doi: 10.1001/jamapsychiatry.2020.2694.
• Rokicki, Jaroslav; Wolfers, Thomas; Nordhøy, Wibeke; Tesli, Natalia; Quintana, Daniel & Alnæs, Dag [Show all 20 contributors for this article] (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping. ISSN 1065-9471. 42(6), p. 1714–1726. doi: 10.1002/hbm.25323. Full text in Research Archive
• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Show all 76 contributors for this article] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Full text in Research Archive
• Engen, Magnus Johan; Lyngstad, Siv Hege; Ueland, Torill; Simonsen, Carmen Elisabeth; Vaskinn, Anja & Smeland, Olav Bjerkehagen [Show all 11 contributors for this article] (2020). Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls. Translational Psychiatry. ISSN 2158-3188. 10:416, p. 1–9. doi: 10.1038/s41398-020-01094-9. Full text in Research Archive
• Drange, Ole Kristian; Sæther, Sverre Georg; Finseth, Per Ivar; Morken, Gunnar; Vaaler, Arne & Arntsen, Vibeke [Show all 11 contributors for this article] (2020). Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study. BMC Psychiatry. ISSN 1471-244X. 20. doi: 10.1186/s12888-020-02968-4. Full text in Research Archive
• Wang, Yunpeng; Nudel, Ron; Benros, Michael Eriksen; Skogstrand, Kristin; Fishilevich, Simon & Lancet, Doron [Show all 14 contributors for this article] (2020). Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth. PLoS Genetics. ISSN 1553-7390. doi: 10.1371/journal.pgen.1009163. Full text in Research Archive
• Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, p. 590–596. doi: 10.1016/j.schres.2020.11.025.
• Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), p. 1–10. doi: 10.1038/s41398-020-00888-1. Full text in Research Archive
• Winterton, Adriano; Rødevand, Linn ; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 9(1). doi: 10.1186/s13643-020-01369-8. Full text in Research Archive
• Cheesman, Rosa; Eilertsen, Espen Moen; Ahmadzadeh, Yasmin I.; Gjerde, Line C.; Hannigan, Laurie John & Havdahl, Alexandra [Show all 13 contributors for this article] (2020). How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa). BMC Medicine. ISSN 1741-7015. 18. doi: 10.1186/s12916-020-01760-1. Full text in Research Archive
• Kia, Seyed Mostafa; Huijsdens, Hester; Dinga, Richard; Wolfers, Thomas; Mennes, Maarten & Andreassen, Ole Andreas [Show all 9 contributors for this article] (2020). Hierarchical bayesian regression for multi-site normative modeling of neuroimaging data. Lecture Notes in Computer Science (LNCS). ISSN 0302-9743. 12267, p. 699–709. doi: 10.1007/978-3-030-59728-3_68.
• Beck, Dani; de Lange, Ann-Marie Glasø; Maximov, Ivan; Richard, Geneviève; Andreassen, Ole Andreas & Nordvik, Jan E. [Show all 7 contributors for this article] (2020). White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction. NeuroImage. ISSN 1053-8119. 224:117441, p. 1–14. doi: 10.1016/j.neuroimage.2020.117441. Full text in Research Archive
• Mäki-Marttunen, Verónica; Andreassen, Ole Andreas & Espeseth, Thomas (2020). The role of norepinephrine in the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 118, p. 298–314. doi: 10.1016/j.neubiorev.2020.07.038. Full text in Research Archive
• Koenig, Julian; Abler, Birgit; Agartz, Ingrid; Åkerstedt, Torbjørn; Andreassen, Ole Andreas & Anthony, Mia [Show all 83 contributors for this article] (2020). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology. ISSN 0048-5772. doi: 10.1111/psyp.13688. Full text in Research Archive Show summary

  Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

• Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir & Winterton, Adriano [Show all 14 contributors for this article] (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 00:110108, p. 1–8. doi: 10.1016/j.pnpbp.2020.110108. Full text in Research Archive
• Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton; Makarious, Mary B.; Kim, Jonggeol J. & Liu, Ganqiang [Show all 48 contributors for this article] (2020). Differences in the presentation and progression of Parkinson's disease by sex. Movement Disorders. ISSN 0885-3185. p. 1–14. doi: 10.1002/mds.28312.
• Gurholt, Tiril Pedersen; Lonning, Vera Louise Hiorth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Haukvik, Unn Kristin H. & Alloza, Clara [Show all 41 contributors for this article] (2020). Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium. Human Brain Mapping. ISSN 1065-9471. p. 1–12. doi: 10.1002/hbm.25212. Full text in Research Archive
• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid & Bjella, Thomas [Show all 12 contributors for this article] (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry. ISSN 1664-0640. 11, p. 1–10. doi: 10.3389/fpsyt.2020.00642. Full text in Research Archive
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund & Johannessen, Cecilie Haggag [Show all 13 contributors for this article] (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia. ISSN 2334-265X. 6, p. 1–8. doi: 10.1038/s41537-020-00112-5. Full text in Research Archive
• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars ; Inderhaug, Elin; Hughes, Timothy & Steen, Nils Eiel [Show all 10 contributors for this article] (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, Behavior, and Immunity. ISSN 0889-1591. 87, p. 634–644. doi: 10.1016/j.bbi.2020.02.008. Full text in Research Archive
• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Show all 40 contributors for this article] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–8. doi: 10.1038/s41380-020-0664-1. Full text in Research Archive
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications. ISSN 2041-1723. 11:3512, p. 1–9. doi: 10.1038/s41467-020-17368-1.
• Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi-Ling; Coleman, Jonathan R.I.; Thornton, Laura M. & Walters, Raymond K. [Show all 104 contributors for this article] (2020). Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies. Addiction Biology. ISSN 1355-6215. doi: 10.1111/adb.12880.
• Aminihajibashi, Samira; Hagen, Thomas; Andreassen, Ole Andreas; Laeng, Bruno & Espeseth, Thomas (2020). The effects of cognitive abilities and task demands on tonic and phasic pupil sizes. Biological Psychology. ISSN 0301-0511. 156. doi: 10.1016/j.biopsycho.2020.107945. Full text in Research Archive
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica & Vedal, Trude Seselie Jahr [Show all 18 contributors for this article] (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00672. Full text in Research Archive
• Fan, Chun Chieh; Banks, Sarah J.; Thompson, Wesley K.; Chen, Chi-Hua; McEvoy, Linda K. & Tan, Chin Hong [Show all 14 contributors for this article] (2020). Sex-dependent autosomal effects on clinical progression of Alzheimer's disease. Brain. ISSN 0006-8950. 143(7), p. 2272–2280. doi: 10.1093/brain/awaa164.
• Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Doan, Nhat Trung & Moberget, Torgeir [Show all 10 contributors for this article] (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry. ISSN 2158-3188. 10(251). doi: 10.1038/s41398-020-00931-1. Full text in Research Archive
• Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2020). Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study. Human Brain Mapping. ISSN 1065-9471. 41(16), p. 4676–4690. doi: 10.1002/hbm.25149. Full text in Research Archive
• Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Full text in Research Archive
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart & Rødevand, Linn Nilsen [Show all 12 contributors for this article] (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research. ISSN 0920-9964. 218, p. 55–62. doi: 10.1016/j.schres.2020.03.006. Full text in Research Archive
• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina & Lunding, Synve Hoffart [Show all 13 contributors for this article] (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior. ISSN 2162-3279. 10(9). doi: 10.1002/brb3.1751. Full text in Research Archive
• Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung & Alnæs, Dag [Show all 33 contributors for this article] (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 5(12), p. 1095–1103. doi: 10.1016/j.bpsc.2020.06.014. Full text in Research Archive
• Barth, Claudia; Lonning, Vera Louise Hiorth; Gurholt, Tiril Pedersen; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0233684. Full text in Research Archive
• Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas & Svalheim, Sigrid (2020). Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure. ISSN 1059-1311. 80, p. 221–225. doi: 10.1016/j.seizure.2020.05.018. Full text in Research Archive
• Smelror, Runar; Rund, Bjørn Rishovd; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Wedervang-Resell, Kirsten & Andreassen, Ole Andreas [Show all 9 contributors for this article] (2020). Negative and disorganized symptoms mediate the relationship between verbal learning and global functioning in adolescents with early-onset psychosis. European Child and Adolescent Psychiatry. ISSN 1018-8827. doi: 10.1007/s00787-020-01479-7. Full text in Research Archive
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva & Abrahamsen, Tore G [Show all 16 contributors for this article] (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal. ISSN 0892-6638. 34(6), p. 8114–8124. doi: 10.1096/fj.201900855RRR.
• Lund, Martina Jonette; Alnæs, Dag; Schwab, Simon; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta [Show all 7 contributors for this article] (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping. ISSN 1065-9471. 41(15), p. 4173–4186. doi: 10.1002/hbm.25116. Full text in Research Archive
• Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Show all 7 contributors for this article] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, p. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
• Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen & Frei, Oleksandr [Show all 22 contributors for this article] (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry. ISSN 0006-3223. 89(3), p. 227–235. doi: 10.1016/j.biopsych.2020.01.026. Full text in Research Archive
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Dale, Anders & Andreassen, Ole Andreas (2020). The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nature Reviews Neurology. ISSN 1759-4758. p. 1–14. doi: 10.1038/s41582-020-0364-0.
• Hjelseng, Ingrid Varvin; Vaskinn, Anja; Ueland, Torill; Lunding, Synve Hoffart; Reponen, Elina Johanna & Steen, Nils Eiel [Show all 8 contributors for this article] (2020). Childhood Trauma Is Associated With Poorer Social Functioning in Severe Mental Disorders Both During an Active Illness Phase and in Remission . Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2020.03.015.
• Vaskinn, Anja; Haatveit, Beathe ; Melle, Ingrid; Andreassen, Ole Andreas; Ueland, Torill & Sundet, Kjetil Søren (2020). Cognitive Heterogeneity Across Schizophrenia and Bipolar Disorder: A Cluster Analysis of Intellectual Trajectories. Journal of the International Neuropsychological Society. ISSN 1355-6177. doi: 10.1017/s1355617720000442.
• Feyer, Frida Karine; Andersson, Stein; Büchmann, Camilla Bakkalia; Melle, Ingrid; Andreassen, Ole Andreas & Vaskinn, Anja (2020). Social perception predicts awareness of illness in persons with schizophrenia. Journal of Nervous and Mental Disease. ISSN 0022-3018. 208(9), p. 701–705. doi: 10.1097/NMD.0000000000001185. Full text in Research Archive
• Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr & Bettella, Francesco [Show all 13 contributors for this article] (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry. ISSN 2168-6238. 77(5), p. 503–512. doi: 10.1001/jamapsychiatry.2019.4188.
• Sjølie, Charlotte; Meyn, Emilie K.; Raudeberg, Rune; Andreassen, Ole Andreas & Vaskinn, Anja (2020). Nonsocial cognitive underpinnings of theory of mind in schizophrenia. Psychiatry Research. ISSN 0165-1781. 289. doi: 10.1016/j.psychres.2020.113055. Full text in Research Archive
• Lyngstad, Siv Hege; Bettella, Francesco; Aminoff, Sofie Ragnhild; Athanasiu, Lavinia; Andreassen, Ole Andreas & Færden, Ann [Show all 7 contributors for this article] (2020). Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 141(5), p. 452–464. doi: 10.1111/acps.13167. Full text in Research Archive
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K. & O'Connell, Kevin S. [Show all 11 contributors for this article] (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex. ISSN 1047-3211. 30(10), p. 5597–5603. doi: 10.1093/cercor/bhaa146. Full text in Research Archive
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato & Friestad, Christine [Show all 9 contributors for this article] (2020). Childhood trauma in persons with schizophrenia and a history of interpersonal violence. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00383. Full text in Research Archive
• Thompson, Paul M.; Jahanshad, Neda; Ching, Christopher R.K.; Salminen, Lauren E.; Thomopoulos, Sophia I. & Bright, Joanna [Show all 170 contributors for this article] (2020). ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry. ISSN 2158-3188. 10:100, p. 1–28. doi: 10.1038/s41398-020-0705-1. Full text in Research Archive
• Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato & Jensen, Arvid [Show all 14 contributors for this article] (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-020-01098-y. Full text in Research Archive
• Izzo, Jessica; Andreassen, Ole Andreas; Westlye, Lars Tjelta & van der Meer, Dennis (2019). The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer’s disease. Brain Research. ISSN 0006-8993. p. 1–7. doi: 10.1016/j.brainres.2019.146591.
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob & Zhu, Zhaozhong [Show all 66 contributors for this article] (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), p. 1469–1482. doi: 10.1016/j.cell.2019.11.020. Full text in Research Archive
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Agartz, Ingrid [Show all 10 contributors for this article] (2019). Lipid alterations in adolescents with early-onset psychosis may be independent of antipsychotic medication. Schizophrenia Research. ISSN 0920-9964. p. 1–7. doi: 10.1016/j.schres.2019.11.039. Full text in Research Archive
• Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E. & McCombie, William R. [Show all 18 contributors for this article] (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics. ISSN 0148-7299. doi: 10.1002/ajmg.b.32716.
• Rahaman, MA; Turner, Jessica A.; Gupta, Cota Navin; Rachakonda, Srinivas; Chen, Jiayu & Liu, Jingyu [Show all 22 contributors for this article] (2019). N-BiC: A Method for Multi-Component and Symptom Biclustering of Structural MRI Data: Application to Schizophrenia. IEEE Transactions on Biomedical Engineering. ISSN 0018-9294. 67(1), p. 110–121. doi: 10.1109/TBME.2019.2908815.
• O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr & Bettella, Francesco [Show all 24 contributors for this article] (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment . Biological Psychiatry. ISSN 0006-3223. 87(12), p. 1052–1062. doi: 10.1016/j.biopsych.2019.11.015. Full text in Research Archive
• Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas & Djurovic, Srdjan [Show all 11 contributors for this article] (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-019-0463-8.
• Ing, Alex J.; Sämann, Philipp G.; Chu, Congying; Tay, Nicole; Biondo, Francesca & Robert, Gabriel [Show all 50 contributors for this article] (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour. ISSN 2397-3374. 3(12), p. 1306–1318. doi: 10.1038/s41562-019-0738-8.
• Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan & Polderman, Tinca J.C. [Show all 10 contributors for this article] (2019). A global overview of pleiotropy and genetic architecture in complex traits. Nature Genetics. ISSN 1061-4036. 51(9), p. 1339–1348. doi: 10.1038/s41588-019-0481-0.
• Aas, Monica; Bellivier, Frank; Bettella, Francesco; Henry, Chantal; Gard, Sebastien & Kahn, Jean-Pierre [Show all 13 contributors for this article] (2019). Childhood maltreatment and polygenic risk in bipolar disorders. Bipolar Disorders. ISSN 1398-5647. p. 1–8. doi: 10.1111/bdi.12851.
• Nalls, Mike A.; Blauwendraat, Cornelis; Vallerga, Costanza L.; Heilbron, Karl; Bandres-Ciga, Sara & Chang, Diana [Show all 51 contributors for this article] (2019). Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurology. ISSN 1474-4422. 18(12), p. 1091–1102. doi: 10.1016/S1474-4422%2819%2930320-5.
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Reponen, Elina Johanna [Show all 13 contributors for this article] (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology. ISSN 0306-4530. 112:104513, p. 1–7. doi: 10.1016/j.psyneuen.2019.104513. Full text in Research Archive
• Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J. & Holmans, Peter [Show all 48 contributors for this article] (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin. ISSN 0586-7614. doi: 10.1093/schbul/sbz061. Show summary

  BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.

• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J. & Stein, Jason L. [Show all 289 contributors for this article] (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, p. 1624–1636. doi: 10.1038/s41588-019-0511-y. Full text in Research Archive
• Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel & Bahrami, Shahram [Show all 10 contributors for this article] (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology. ISSN 0893-133X. p. 1–9. doi: 10.1038/s41386-019-0556-8. Full text in Research Archive
• O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Frei, Oleksandr [Show all 20 contributors for this article] (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. p. 1–11. doi: 10.1038/s41380-019-0613-z. Full text in Research Archive
• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas & Jonassen, Rune [Show all 10 contributors for this article] (2019). Brain connectome mapping of complex human traits and their polygenic architecture using machine learning. Biological Psychiatry. ISSN 0006-3223. p. 1–10. doi: 10.1016/j.biopsych.2019.10.011. Full text in Research Archive Show summary

  Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remains a challenge. Methods In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety and neuroticism using fMRI-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes, and 13 different neuroticism traits and schizophrenia. Results Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism and polygenic scores across traits. Conclusion These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with fMRI-based brain connectomics.

• Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen & Choi, Karmel W. [Show all 179 contributors for this article] (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications. ISSN 2041-1723. 10:4558, p. 1–16. doi: 10.1038/s41467-019-12576-w. Full text in Research Archive
• Kremen, William S.; Panizzon, Matthew S.; Elman, Jeremy A.; Granholm, Eric L.; Andreassen, Ole Andreas & Dale, Anders [Show all 14 contributors for this article] (2019). Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk. Neurobiology of Aging. ISSN 0197-4580. 83, p. 114–121. doi: 10.1016/j.neurobiolaging.2019.09.001.
• Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10:649, p. 1–8. doi: 10.3389/fpsyt.2019.00649. Full text in Research Archive
• de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, André & Alpert, Kathryn I. [Show all 91 contributors for this article] (2019). The association between familial risk and brain abnormalities is disease specific: An ENIGMA-relatives study of schizophrenia and bipolar disorder. Biological Psychiatry. ISSN 0006-3223. 86(7), p. 545–556. doi: 10.1016/j.biopsych.2019.03.985. Full text in Research Archive
• Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel & Abé, Christoph [Show all 59 contributors for this article] (2019). Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology. ISSN 0893-133X. 44, p. 2285–2293. doi: 10.1038/s41386-019-0485-6.
• Bakke, Laura A. Wortinger ; Engen, Kristine; Barth, Claudia; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø & Andreassen, Ole Andreas [Show all 10 contributors for this article] (2019). Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants. Psychological Medicine. ISSN 0033-2917. p. 1–9. doi: 10.1017/S0033291719002046.
• Holmen, Tom Langerud; Egeland, Jens; Andersen, Eivind; Mordal, Jon; Andreassen, Ole Andreas & Ueland, Thor [Show all 9 contributors for this article] (2019). The association between cardiorespiratory fitness and cognition appears neither related to current physical activity nor mediated by brain-derived neurotrophic factor in a sample of outpatients with schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 10:785, p. 1–7. doi: 10.3389/fpsyt.2019.00785. Full text in Research Archive Show summary

  Objective: We investigated whether levels of current physical activity (PA) contribute to the established relationship between cardiorespiratory fitness (CRF) and cognition in schizophrenia and whether brain-derived neurotrophic factor (BDNF) or its precursor proBDNF mediates this relationship. Method: Sixty-one outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale (WAIS) and nine subtests from the MATRICS battery comprising a neurocognitive composite score (NCS). CRF was assessed with peak oxygen uptake (VO2peak) measured directly during a maximum exercise test. Current PA levels were objectively assessed by an accelerometer worn for four consecutive days. BDNF and proBDNF were measured in fasting blood. Four serial parallel mediation analyses and two additional parallel mediation analyses were conducted, while controlling for age and sex at all levels. Results: No direct effects were found between PA measures and WAIS or NCS. No significant mediating effects of CRF or BDNF/proBDNF were detected. Conclusion: The results do not support the hypothesis that PA contributes to the naturally occurring relationship between CRF and cognition in schizophrenia or the hypothesis that BDNF or proBDNF mediates this relationship. The results arguably support the assumption that the association between CRF and cognition in schizophrenia is established developmentally early.

• Simonsen, Carmen Elisabeth; Aminoff, Sofie Ragnhild; Vaskinn, Anja; Barrett, Elizabeth Ann; Færden, Ann & Ueland, Torill [Show all 9 contributors for this article] (2019). Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 95:152134, p. 1–8. doi: 10.1016/j.comppsych.2019.152134. Full text in Research Archive
• Frøyhaug, Mathias; Andersson, Stein; Andreassen, Ole Andreas; Ueland, Torill & Vaskinn, Anja (2019). Theory of mind in schizophrenia and bipolar disorder: psychometric properties of the Norwegian version of the Hinting Task. Cognitive Neuropsychiatry. ISSN 1354-6805. 24(6), p. 454–469. doi: 10.1080/13546805.2019.1674645. Full text in Research Archive
• Gudmundsson, Ólafur Ó.; Walters, Gudmundur Bragi; Ingason, Andrés; Johansson, Stefan; Zayats, Tetyana & Athanasiu, Lavinia [Show all 27 contributors for this article] (2019). Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational Psychiatry. ISSN 2158-3188. 9, p. 1–9. doi: 10.1038/s41398-019-0599-y. Full text in Research Archive
• Icick, Romain; Melle, Ingrid; Étain, Bruno; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild & Leboyer, Marion. [Show all 12 contributors for this article] (2019). Tobacco smoking and other substance use disorders associated with recurrent suicide attempts in bipolar disorder. Journal of Affective Disorders. ISSN 0165-0327. 256, p. 348–357. doi: 10.1016/j.jad.2019.05.075.
• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel & Ames, David [Show all 132 contributors for this article] (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2019.3779. Show summary

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience. ISSN 1662-5188. 13. doi: 10.3389/fncom.2019.00066. Full text in Research Archive
• Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton L.; Kim, Jonggeol J.; Liu, Ganqiang & Maple-Grødem, Jodi [Show all 45 contributors for this article] (2019). Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. Movement Disorders. ISSN 0885-3185. 34(12), p. 1839–1850. doi: 10.1002/mds.27845.
• Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte & Mehta, Divya [Show all 117 contributors for this article] (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry. ISSN 0002-953X. 176(8), p. 651–660. doi: 10.1176/appi.ajp.2019.18080957. Full text in Research Archive
• de Lange, Ann-Marie Glasø; Kaufmann, Tobias; van der Meer, Dennis; Maglanoc, Luigi Angelo; Alnæs, Dag & Moberget, Torgeir [Show all 9 contributors for this article] (2019). Population-based neuroimaging reveals traces of childbirth in the maternal brain. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), p. 22341–22346. doi: 10.1073/pnas.1910666116.
• Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu & Etain, Bruno [Show all 61 contributors for this article] (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. ISSN 2194-7511. 7(1), p. 1–10. doi: 10.1186/s40345-019-0156-x. Full text in Research Archive
• Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar & Rongve, Arvid [Show all 23 contributors for this article] (2019). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease. Translational Psychiatry. ISSN 2158-3188. 9:273, p. 1–10. doi: 10.1038/s41398-019-0592-5. Full text in Research Archive
• Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma & Davies, Gail [Show all 68 contributors for this article] (2019). Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics. ISSN 0002-9297. 105(2), p. 334–350. doi: 10.1016/j.ajhg.2019.06.012. Full text in Research Archive
• Mahmood, Javed Iqbal; Grotmol, Kjersti Støen; Tesli, Martin Steen; Moum, Torbjørn Åge; Andreassen, Ole Andreas & Tyssen, Reidar (2019). Life satisfaction in Norwegian medical doctors: a 15-year longitudinal study of work-related predictors. BMC Health Services Research. ISSN 1472-6963. 19:729, p. 1–10. doi: 10.1186/s12913-019-4599-7. Full text in Research Archive
• Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta & Calhoun, Vince D. [Show all 7 contributors for this article] (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder. NeuroImage: Clinical. ISSN 2213-1582. p. 1–9. doi: 10.1016/j.nicl.2019.101989. Full text in Research Archive
• Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav & Moberget, Torgeir [Show all 30 contributors for this article] (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry. ISSN 2168-6238. 76(7), p. 739–748. doi: 10.1001/jamapsychiatry.2019.0257.
• Torske, Tonje; Nærland, Terje; Bettella, Francesco; Bjella, Thomas; Malt, Eva Albertsen & Høyland, Anne Lise [Show all 9 contributors for this article] (2019). Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment . Autism Research. ISSN 1939-3792. doi: 10.1002/aur.2207. Full text in Research Archive
• Vaskinn, Anja; Løvgren, André; Egeland, Maj Kristoffersen; Feyer, Frida Karine; Østefjells, Tiril & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2019). A randomized controlled trial of training of affect recognition (TAR) in schizophrenia shows lasting effects for theory of mind. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(5), p. 611–620. doi: 10.1007/s00406-019-00997-z. Full text in Research Archive
• Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr & Nordvik, Jan Egil [Show all 11 contributors for this article] (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, p. 1–9. doi: 10.3389/fneur.2019.00450. Full text in Research Archive
• Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K. & Won, Hyejung [Show all 76 contributors for this article] (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics. ISSN 1061-4036. 51, p. 431–444. doi: 10.1038/s41588-019-0344-8.
• Elman, Jeremy A.; Panizzon, Matthew S; Logue, Mark W.; Gillespie, Nathan A.; Neale, Michael C. & Reynolds, Chandra A. [Show all 13 contributors for this article] (2019). Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiology of Aging. ISSN 0197-4580. doi: 10.1016/j.neurobiolaging.2019.06.001.
• Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), p. 503–508. doi: 10.1097/FTD.0000000000000619.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh & Bahrami, Shahram [Show all 11 contributors for this article] (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics. ISSN 0340-6717. p. 1–10. doi: 10.1007/s00439-019-02060-2. Full text in Research Archive
• Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias & Ardau, Raffaella [Show all 105 contributors for this article] (2019). Association between solar insolation and a history of suicide attempts in bipolar I disorder. Journal of Psychiatric Research. ISSN 0022-3956. 113, p. 1–9. doi: 10.1016/j.jpsychires.2019.03.001.
• Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan & Westlye, Lars Tjelta [Show all 23 contributors for this article] (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10. doi: 10.3389/fpsyt.2019.00534. Full text in Research Archive
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. ISSN 0162-3257. p. 1–17. doi: 10.1007/s10803-019-04112-y. Full text in Research Archive
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics. ISSN 0955-8829. 29(5), p. 152–159. doi: 10.1097/YPG.0000000000000234. Full text in Research Archive Show summary

  Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a large number of common variants each with a small effect and many genetic variants influence more than one phenotype, suggesting shared genetic etiology. These concepts have the potential to revolutionize the current classification system with diagnostic categories and facilitate development of better treatments. However, to reach clinical impact, we need larger samples and better analytical tools, as most polygenic factors remain undetected. We here present statistical approaches designed to improve the yield of existing genome-wide association studies for polygenic phenotypes. We review how these tools have informed the current knowledge on the genetic architecture of psychiatric disorders, focusing on schizophrenia, bipolar disorder and major depression, and overlap with psychological and cognitive traits. We discuss application of statistical tools for stratification and prediction.

• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Show all 84 contributors for this article] (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), p. 1617–1623. doi: 10.1038/s41593-019-0471-7. Full text in Research Archive
• Anderssen, Jannicke Fjæra; Simonsen, Carmen Elisabeth; Büchmann, Camilla Bakkalia; Barrett, Elizabeth Ann; Bjella, Thomas & Lagerberg, Trine Vik [Show all 10 contributors for this article] (2019). Sleep disturbances in schizophrenia spectrum and bipolar disorders ? a transdiagnostic perspective. Comprehensive Psychiatry. ISSN 0010-440X. 91, p. 6–12. doi: 10.1016/j.comppsych.2019.02.006. Full text in Research Archive
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan & Trubetskoy, Vassily [Show all 277 contributors for this article] (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. ISSN 1061-4036. 51(5), p. 793–803. doi: 10.1038/s41588-019-0397-8. Full text in Research Archive
• Watson, Hunna J.; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R. I. & Gaspar, Héléna A. [Show all 210 contributors for this article] (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics. ISSN 1061-4036. 51(8), p. 1207–1214. doi: 10.1038/s41588-019-0439-2.
• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh & Mæland, Steffen [Show all 12 contributors for this article] (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10310-0. Full text in Research Archive
• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas & Jonassen, Rune [Show all 10 contributors for this article] (2019). Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics. Nature Neuroscience. ISSN 1097-6256. doi: 10.1101/609586.
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Reponen, Elina Johanna [Show all 9 contributors for this article] (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(5), p. 464–471. doi: 10.1111/acps.13019. Full text in Research Archive
• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. p. 1–10. doi: 10.1007/s00406-019-01017-w. Full text in Research Archive
• Solberg, Dag Kristen; Refsum, Helge; Andreassen, Ole Andreas & Bentsen, Håvard (2019). A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia. Acta Neuropsychiatrica. ISSN 0924-2708. 31(4), p. 202–212. doi: 10.1017/neu.2019.14.
• Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo & Norbom, Linn Christin Bonaventure [Show all 10 contributors for this article] (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry. ISSN 0006-3223. 86(1), p. 65–75. doi: 10.1016/j.biopsych.2019.01.019. Full text in Research Archive
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia & Djurovic, Srdjan [Show all 12 contributors for this article] (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry. ISSN 2158-3188. 9. doi: 10.1038/s41398-019-0432-7. Full text in Research Archive
• Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla & Clarimon, Jordi [Show all 40 contributors for this article] (2019). GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific Reports. ISSN 2045-2322. 9. doi: 10.1038/s41598-019-43458-2. Full text in Research Archive
• Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias & Còrdova Palomera, Aldo [Show all 9 contributors for this article] (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-08503-8. Full text in Research Archive
• Di Sero, Alessia; Jørgensen, Kjetil Nordbø; Nerland, Stener; Melle, Ingrid; Andreassen, Ole Andreas & Jovicich, Jorge [Show all 7 contributors for this article] (2019). Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status. Schizophrenia Research. ISSN 0920-9964. 208, p. 114–123. doi: 10.1016/j.schres.2019.04.002.
• Zak, Nathalia; Bøen, Erlend; Boye, Birgitte; Andreassen, Ole Andreas; Doan, Nhat Trung & Malt, Ulrik Fredrik [Show all 8 contributors for this article] (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders. ISSN 1398-5647. 21, p. 525–538. doi: 10.1111/bdi.12771. Full text in Research Archive
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen & Matson, Wayne [Show all 13 contributors for this article] (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2). doi: 10.1017/S0033291719000400. Full text in Research Archive
• Storvestre, Guttorm Breivik; Valnes, Lars Magnus; Jensen, Arvid; Nerland, Stener; Tesli, Natalia & Hymer, Knut-Erik [Show all 14 contributors for this article] (2019). A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 288, p. 29–36. doi: 10.1016/j.pscychresns.2019.04.013. Full text in Research Archive
• Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M. & Bybjerg-Grauholm, Jonas [Show all 15 contributors for this article] (2019). Association of polygenic liabilities for major depression, bipolar disorder, and schizophrenia with risk for depression in the Danish population. JAMA psychiatry. ISSN 2168-6238. 76(5), p. 516–525. doi: 10.1001/jamapsychiatry.2018.4166.
• Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias & Wolfers, Thomas [Show all 38 contributors for this article] (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 9(12). doi: 10.1038/s41398-018-0225-4. Full text in Research Archive
• Tan, Chin Hong; Bonham, Luke W.; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P. & Broce, Iris J. [Show all 24 contributors for this article] (2019). Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. ISSN 0006-8950. 142(2), p. 460–470. doi: 10.1093/brain/awy327.
• Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid & Melle, Ingrid [Show all 8 contributors for this article] (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-019-00988-0.
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig & Ness, Torbjørn V [Show all 16 contributors for this article] (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), p. 875–891. doi: 10.1093/cercor/bhy291. Full text in Research Archive
• Sanyal, Nilotpal; Lo, Min-Tzu; Kauppi, Karolina; Djurovic, Srdjan; Andreassen, Ole Andreas & Johnson, Valen E. [Show all 7 contributors for this article] (2019). GWASinlps: Non-local prior based iterative SNP selection tool for genome-wide association studies. Bioinformatics. ISSN 1367-4803. 35(1), p. 1–11. doi: 10.1093/bioinformatics/bty472.
• Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill & Melle, Ingrid [Show all 9 contributors for this article] (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2019.01.011. Full text in Research Archive
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun & Hoseth, Eva Zsuzsanna [Show all 17 contributors for this article] (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine. ISSN 0033-2917. 49(10), p. 1749–1757. doi: 10.1017/S0033291718004142.
• Wang, Yunpeng; Karstoft, Karen-Inge; Nievergelt, Caroline M.; Maihofer, Adam X.; Stein, Murray B. & Ursano, Robert J. [Show all 13 contributors for this article] (2019). Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations. Journal of Affective Disorders. ISSN 0165-0327. 252, p. 350–357. doi: 10.1016/j.jad.2019.04.070.
• Engh, John; Egeland, Jens; Andreassen, Ole Andreas; Bang-Kittilsen, Gry; Bigseth, Therese Torgersen & Holmen, Tom Langerud [Show all 9 contributors for this article] (2019). Objectively Assessed Daily Steps—Not Light Intensity Physical Activity, Moderate-to-Vigorous Physical Activity and Sedentary Time—Is Associated With Cardiorespiratory Fitness in Patients With Schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 10. doi: 10.3389/fpsyt.2019.00082. Full text in Research Archive
• Høyland, Anne Lise; Nærland, Terje; Engstrøm, Morten; Torske, Tonje; Lydersen, Stian & Andreassen, Ole Andreas (2019). Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study. Molecular Autism. ISSN 2040-2392. 10(10). doi: 10.1186/s13229-019-0259-3. Full text in Research Archive
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree & Frei, Oleksandr [Show all 52 contributors for this article] (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13. doi: 10.3389/fnins.2019.00220. Full text in Research Archive
• Rødevand, Linn ; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna & Mørch, Ragni Helene [Show all 12 contributors for this article] (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(4), p. 348–360. doi: 10.1111/acps.13008.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin & Savage, Jeanne E. [Show all 15 contributors for this article] (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry. ISSN 1359-4184. p. 1–10. doi: 10.1038/s41380-018-0332-x. Full text in Research Archive
• Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M. & Steinberg, Stacy [Show all 53 contributors for this article] (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics. ISSN 1061-4036. 51(3), p. 404–413. doi: 10.1038/s41588-018-0311-9. Full text in Research Archive
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, p. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Full text in Research Archive
• de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L. & Ota, Vanessa K. [Show all 22 contributors for this article] (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. ISSN 2399-3642. 1(163). doi: 10.1038/s42003-018-0155-y. Full text in Research Archive
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; wenhao, jiang & Glahn, David C [Show all 123 contributors for this article] (2018). Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.10.003.
• Bauer, Michael; Andreassen, Ole Andreas; Geddes, John R.; Kessing, Lars Vedel; Lewitzka, Ute & Schulze, Thomas G [Show all 7 contributors for this article] (2018). Areas of uncertainties and unmet needs in bipolar disorders: clinical and research perspectives. The Lancet Psychiatry. ISSN 2215-0374. 5(11), p. 930–939. doi: 10.1016/S2215-0366%2818%2930253-0.
• Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke & Berg-Hansen, Pål [Show all 12 contributors for this article] (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. p. 1–12. doi: 10.1177/1352458518765671. Full text in Research Archive
• Kauppi, Karolina; rosenthal, sara brin; Lo, Min-Tzu; Sanyal, Nilotpal; Jiang, Mian & Abagyan, Ruben [Show all 9 contributors for this article] (2018). Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia. American Journal of Psychiatry. ISSN 0002-953X. 175(7), p. 674–682. doi: 10.1176/appi.ajp.2017.17040410. Full text in Research Archive
• Broce, Iris J.; Tan, Chin Hong; Fan, CC; Jansen, Iris E.; Savage, Jeanne E. & Witoelar, Aree [Show all 34 contributors for this article] (2018). Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica. ISSN 0001-6322. doi: 10.1007/s00401-018-1928-6.
• Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders & Doan, Nhat Trung [Show all 13 contributors for this article] (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ. ISSN 2167-8359. doi: 10.7717/peerj.5908. Full text in Research Archive
• McCarthy, Michael J.; Wei, Heather; Nievergelt, Caroline M.; Stautland, Andrea; Maihofer, Adam X. & Welsh, David K [Show all 51 contributors for this article] (2018). Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. ISSN 0893-133X. 44(3), p. 620–628. doi: 10.1038/s41386-018-0273-8. Full text in Research Archive Show summary

  Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patients, we measured circadian rhythms in fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-R patients were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP3 signaling pathway may account for some of the individual differences in the effects of lithium on cellular rhythms. We conclude that circadian rhythms may influence response to lithium in maintenance treatment of BD.

• Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2018.0844.
• Aas, Monica; Djurovic, Srdjan; Ueland, Torill; Mørch, Ragni Helene; Anderssen, Jannicke Fjæra & Reponen, Elina Johanna [Show all 11 contributors for this article] (2018). The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. doi: 10.1080/15622975.2018.1557345.
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr & Steen, Vidar Martin [Show all 8 contributors for this article] (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(7), p. 795–802. doi: 10.1007/s00406-018-0897-z. Full text in Research Archive
• Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Steen, Vidar Martin; Andreassen, Ole Andreas & Le Hellard, Stephanie (2018). Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2018.11.025. Full text in Research Archive
• Smelror, Runar; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Kelleher, Ian; Cannon, Mary & DeRosse, Pamela [Show all 16 contributors for this article] (2018). Healthy adolescent performance with standardized scoring tables for the MATRICS Consensus Cognitive Battery: A multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 45(4), p. 773–783. doi: 10.1093/schbul/sby131.
• Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas & White, Linda Rosemary [Show all 33 contributors for this article] (2018). Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-36429-6. Full text in Research Archive
• Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Kaufmann, Tobias; Mahmoud, Ramy A. & Smerud, Knut Terje [Show all 8 contributors for this article] (2018). Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study. Neuropsychopharmacology. ISSN 0893-133X. 44, p. 306–313. doi: 10.1038/s41386-018-0241-3.
• Demontis, Ditte; Walters, Raymond K.; Martin, Joanna; Mattheisen, Manuel; Als, Thomas D. & Agerbo, Esben [Show all 50 contributors for this article] (2018). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. ISSN 1061-4036. 51, p. 63–75. doi: 10.1038/s41588-018-0269-7. Full text in Research Archive
• Holmen, Tom Langerud; Engh, John; Andersen, Eivind; Andreassen, Ole Andreas; Martinsen, Egil Wilhelm & Bigseth, Therese Torgersen [Show all 8 contributors for this article] (2018). Cardio-respiratory fitness is associated with a verbal factor across cognitive domains in schizophrenia. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2018.11.033. Full text in Research Archive
• Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James & Stahl, Eli A. [Show all 52 contributors for this article] (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell. ISSN 0092-8674. 173(7), p. 1705–1715. doi: 10.1016/j.cell.2018.05.046.
• Bettella, Francesco; Brown, AA; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Witoelar, Aree & Buil Demur, AA [Show all 11 contributors for this article] (2018). Cross-tissue eQTL enrichment of associations in schizophrenia. PLOS ONE. ISSN 1932-6203. 13(9). doi: 10.1371/journal.pone.0202812. Full text in Research Archive
• Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Vidar Martin [Show all 7 contributors for this article] (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 282, p. 55–63. doi: 10.1016/j.pscychresns.2018.10.001.
• Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir & Rokicki, Jaroslav [Show all 9 contributors for this article] (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.09.027. Full text in Research Archive
• Kvam, Tor-Morten; Stewart, Lowan H. & Andreassen, Ole Andreas (2018). Psykedeliske stoffer i behandling av angst, depresjon og avhengighet. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(18). doi: 10.4045/tidsskr.17.1110.
• Kulkarni, Rishikesh U; Vandenberghe, Matthieu; Thunemann, Martin; James, Feroz; Andreassen, Ole Andreas & Djurovic, Srdjan [Show all 8 contributors for this article] (2018). In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes. ACS Central Science. ISSN 2374-7943. 4(10), p. 1371–1378. doi: 10.1021/acscentsci.8b00422. Full text in Research Archive
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna & Gran, Jon Michael [Show all 16 contributors for this article] (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139, p. 37–45. doi: 10.1111/acps.12971.
• Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir & Agartz, Ingrid [Show all 14 contributors for this article] (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry. ISSN 2168-6238. 75(11), p. 1146–1155. doi: 10.1001/jamapsychiatry.2018.2467.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Show all 11 contributors for this article] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, p. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
• Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas & Dietrichs, Espen [Show all 9 contributors for this article] (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep. ISSN 0161-8105. 41(10). doi: 10.1093/sleep/zsy145. Full text in Research Archive
• Bonham, Luke W.; Karch, Celeste M.; Fan, Chun C.; Tan, Chin; Geier, Ethan G. & Wang, Yunpeng [Show all 25 contributors for this article] (2018). CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry. ISSN 2158-3188. 8:73, p. 1–10. doi: 10.1038/s41398-017-0049-7. Full text in Research Archive
• Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra & Espeseth, Thomas [Show all 15 contributors for this article] (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. p. 1–16. doi: 10.1038/s41380-019-0358-8. Full text in Research Archive
• Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon & Bis, Joshua C. [Show all 91 contributors for this article] (2018). Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications. ISSN 2041-1723. 9:3945, p. 1–11. doi: 10.1038/s41467-018-06234-w. Full text in Research Archive
• Li, Yi; Barkovich, Matthew J.; Karch, Celeste M.; Nillo, Ryan M.; Fan, Chun-Chieh & Broce, Iris J. [Show all 25 contributors for this article] (2018). Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Scientific Reports. ISSN 2045-2322. 8:13373, p. 1–10. doi: 10.1038/s41598-018-31075-4. Full text in Research Archive
• Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Yokoyama, Jennifer S.; Kouri, Naomi & Ross, Owen A. [Show all 21 contributors for this article] (2018). Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum. JAMA Neurology. ISSN 2168-6149. 75(7), p. 860–875. doi: 10.1001/jamaneurol.2018.0372.
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir & Alnæs, Dag [Show all 54 contributors for this article] (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–13. doi: 10.1038/s41380-018-0262-7. Full text in Research Archive
• Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn & Athanasiu, Lavinia [Show all 24 contributors for this article] (2018). Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 8(210), p. 1–10. doi: 10.1038/s41398-018-0175-x. Full text in Research Archive
• Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N. & Alda, Martin [Show all 74 contributors for this article] (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-018-0228-9. Full text in Research Archive
• Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe & Ulrichsen, Kristine Moe [Show all 10 contributors for this article] (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro. ISSN 2373-2822. 5(4), p. 1–13. doi: 10.1523/ENEURO.0092-18.2018. Full text in Research Archive
• Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo & van der Meer, Dennis [Show all 15 contributors for this article] (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging . Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-32355-9. Full text in Research Archive
• Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R. & Pearlson, Godfrey D. [Show all 29 contributors for this article] (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin. ISSN 0586-7614. 45(1), p. 222–232. doi: 10.1093/schbul/sby010.
• Mørch-Johnsen, Lynn; Nerland, Stener; Jørgensen, Kjetil Nordbø; Osnes, Kåre; Hartberg, Cecilie Bhandari & Andreassen, Ole Andreas [Show all 9 contributors for this article] (2018). Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. Bipolar Disorders. ISSN 1398-5647. 20(7), p. 647–657. doi: 10.1111/bdi.12627.
• Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin & Hughes, Timothy [Show all 7 contributors for this article] (2018). Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance. Scientific Reports. ISSN 2045-2322. 8:12654, p. 1–11. doi: 10.1038/s41598-018-30898-5. Full text in Research Archive
• Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng & Witoelar, Aree [Show all 17 contributors for this article] (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports. ISSN 2045-2322. 8:12585, p. 1–9. doi: 10.1038/s41598-018-30387-9. Full text in Research Archive
• Berg, Akiah Ottesen; Jørgensen, Kjetil Nordbø; Nerhus, Mari; Athanasiu, Lavinia; Popejoy, Alice & Bettella, Francesco [Show all 13 contributors for this article] (2018). Vitamin D levels, brain volume, and genetic architecture in patients with psychosis. PLOS ONE. ISSN 1932-6203. 13(8). doi: 10.1371/journal.pone.0200250. Full text in Research Archive
• Ringen, Petter Andreas; Falk, Ragnhild Sørum; Antonsen, Bjørnar Torske; Færden, Ann; Mamen, Asgeir & Rognli, Eline Borger [Show all 9 contributors for this article] (2018). Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: A naturalistic interventional study. BMC Psychiatry. ISSN 1471-244X. 18. doi: 10.1186/s12888-018-1832-6. Full text in Research Archive
• Gurholt, Tiril Pedersen; Osnes, Kåre; Nerhus, Mari; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth & Berg, Akiah Ottesen [Show all 9 contributors for this article] (2018). Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-29141-y. Full text in Research Archive
• Drange, Ole Kristian; Vaaler, Arne; Morken, Gunnar; Andreassen, Ole Andreas; Malt, Ulrik Fredrik & Finseth, Per Ivar (2018). Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study. International journal of bipolar disorders. ISSN 2194-7511. 6(19). doi: 10.1186/s40345-018-0128-6. Full text in Research Archive
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun & Reponen, Elina Johanna [Show all 12 contributors for this article] (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2018.08.007. Full text in Research Archive
• LeBlanc, Marissa; Zuber, Verena; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Frigessi Di Rattalma, Arnoldo & Kulle, Bettina (2018). A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework. BMC Genomics. ISSN 1471-2164. 19:494, p. 1–15. doi: 10.1186/s12864-018-4859-7. Full text in Research Archive
• Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid & Djurovic, Srdjan [Show all 11 contributors for this article] (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-28160-z. Full text in Research Archive
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao & Glahn, David C. [Show all 151 contributors for this article] (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.04.023. Full text in Research Archive
• Kauppi, Karolina; Fan, Chun Chieh; McEvoy, Linda K.; Holland, Dominic; Tan, Chin Hong & Chen, Chi-Hua [Show all 9 contributors for this article] (2018). Combining polygenic hazard score with volumetric MRI and cognitive measures improves prediction of progression from mild cognitive impairment to Alzheimer's disease. Frontiers in Neuroscience. ISSN 1662-4548. 12. doi: 10.3389/fnins.2018.00260. Full text in Research Archive
• Simonsen, Carmen Elisabeth; Færden, Ann; Ueland, Torill; Vaskinn, Anja; Bjella, Thomas & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2018). Self-rated disability in first treated episode of psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 85, p. 48–54. doi: 10.1016/j.comppsych.2018.06.004. Full text in Research Archive
• Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung & van der Meer, Dennis [Show all 12 contributors for this article] (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), p. 1049–1059. doi: 10.1038/s41431-018-0134-2.
• Quintana, Daniel; Smerud, Knut Terje; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Evidence for intranasal oxytocin delivery to the brain: Recent advances and future perspectives. Therapeutic delivery. ISSN 2041-5990. 9(7), p. 515–525. doi: 10.4155/tde-2018-0002. Full text in Research Archive
• Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut Terje; Mahmoud, Ramy A.; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior. ISSN 0018-506X. 102, p. 85–92. doi: 10.1016/j.yhbeh.2018.05.004.
• Logue, Mark W.; Panizzon, Matthew S.; Elman, Jeremy A.; Gillespie, Nathan A.; Hatton, Sean N. & Gustavson, Daniel E. [Show all 14 contributors for this article] (2018). Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Molecular Psychiatry. ISSN 1359-4184. p. 1–10. doi: 10.1038/s41380-018-0030-8.
• Fan, Chun Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Chen, Chi-Hua; Holland, Dominic & Lo, Min-Tzu [Show all 11 contributors for this article] (2018). Beyond heritability: Improving discoverability in imaging genetics. Human Molecular Genetics. ISSN 0964-6906. 27(1), p. R22–R28. doi: 10.1093/hmg/ddy082.
• Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien & de Leeuw, Christiaan A. [Show all 117 contributors for this article] (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics. ISSN 1061-4036. 50, p. 912–919. doi: 10.1038/s41588-018-0152-6.
• Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha & Chen, Chi-Hua [Show all 16 contributors for this article] (2018). Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational Psychiatry. ISSN 2158-3188. 8:114(1), p. 1–8. doi: 10.1038/s41398-018-0166-y. Full text in Research Archive
• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg & Dieset, Ingrid [Show all 10 contributors for this article] (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research. ISSN 0165-1781. 267, p. 140–147. doi: 10.1016/j.psychres.2018.05.065. Full text in Research Archive
• Ringen, Petter Andreas; Færden, Ann; Antonsen, Bjørnar Torske; Falk, Ragnhild Sørum; Mamen, Asgeir & Rognli, Eline Borger [Show all 9 contributors for this article] (2018). Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-term psychiatric inpatient departments. Nordic Journal of Psychiatry. ISSN 0803-9488. 72(4), p. 296–302. doi: 10.1080/08039488.2018.1449012. Full text in Research Archive
• Vaskinn, Anja; Andersson, Stein; Østefjells, Tiril; Andreassen, Ole Andreas & Sundet, Kjetil Søren (2018). Emotion perception, non-social cognition and symptoms as predictors of theory of mind in schizophrenia. Comprehensive Psychiatry. ISSN 0010-440X. 85, p. 1–7. doi: 10.1016/j.comppsych.2018.05.002. Full text in Research Archive
• Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose & Duncan, Laramie [Show all 571 contributors for this article] (2018). Analysis of shared heritability in common disorders of the brain. Science. ISSN 0036-8075. 360(6395). doi: 10.1126/science.aap8757.
• Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle & Vandenberghe, Matthieu [Show all 16 contributors for this article] (2018). Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nature Communications. ISSN 2041-1723. 9:2015, p. 1–12. doi: 10.1038/s41467-018-04457-5. Full text in Research Archive
• Zak, Nathalia; Moberget, Torgeir; Bøen, Erlend; Boye, Birgitte; Waage, Trine Rygvold & Dietrichs, Espen [Show all 12 contributors for this article] (2018). Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals. Translational Psychiatry. ISSN 2158-3188. 8(103). doi: 10.1038/s41398-018-0151-5. Full text in Research Archive
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Show all 221 contributors for this article] (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. ISSN 2041-1723. 9(2098), p. 1–16. doi: 10.1038/s41467-018-04362-x. Full text in Research Archive
• Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J. & Bettella, Francesco [Show all 10 contributors for this article] (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 177(4), p. 454–467. doi: 10.1002/ajmg.b.32634.

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• Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Malt, Eva Albertsen & Melle, Ingrid (2020). Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S. ISBN 978-82-05-52662-4. 519 p.

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• Johannessen, Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Kaale, Anett & Wirgenes, Katrine Verena [Show all 10 contributors for this article] (2021). Correction to: Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health (European Journal of Human Genetics, (2021), 10.1038/s41431-021-00966-y). European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/s41431-021-01021-6.
• Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey A.; Bahrami, Shahram & Holland, Dominic [Show all 114 contributors for this article] (2021). Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease (Nature Genetics, (2021), 53, 9, (1276-1282), 10.1038/s41588-021-00921-z). Nature Genetics. ISSN 1061-4036. doi: 10.1038/s41588-021-00977-x.
• Hannigan, Laurie John; Corfield, Elizabeth; Biele, Guido; Tilling, Kate; McAdams, Tom A. & Badini, Isabella [Show all 19 contributors for this article] (2021). The genomic basis of participation in the Norwegian Mother, Father and Child Cohort Study.
• Ayorech, Ziada; Gillespie Cheesman, Rosa Catherine; Eilertsen, Espen Moen; Torvik, Fartein Ask; Andreassen, Ole & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Investigating Heterogeneity in Depression Using Multiple Polygenic Scores.
• Barkhuizen, Wikus; Pingault, Jean-Baptiste; Wang, Biyao; Hannigan, Laurie John; Eilertsen, Espen Moen & Andreassen, Ole [Show all 14 contributors for this article] (2021). Direct and indirect genetic influences involved in the intergenerational transmission of risk for ADHD in the Norwegian Mother, Father and Child Cohort.
• Ayorech, Ziada; Davies, Neil; Wootton, Robyn; Watson, Hunna J; Hannigan, Laurie John & Askeland, Ragna Bugge [Show all 17 contributors for this article] (2021). Differential causal risk patterns in childhood eating behaviours compared to adulthood anorexia nervosa. A Mendelian randomization study.
• Hughes, Amanda; Morris, Tim; Ayorech, Ziada; Tesli, Martin Steen; Ask, Helga & Askeland, Ragna Bugge [Show all 16 contributors for this article] (2021). The causal effect of BMI on neurodevelopment: a within family Mendelian randomization study using MoBa. International Journal of Epidemiology. ISSN 0300-5771. 50(Suppl 1). doi: 10.1093/ije/dyab168.296.
• Lennox, Ziada Ayorech; Davies, Neil; Hannigan, Laurie John; Askeland, Ragna Bugge; Tesli, Martin Steen & Andreassen, Ole Andreas [Show all 14 contributors for this article] (2020). Which Metabo-Psychiatric Factors Affect the Risk of Anorexia Nervosa? A Mendelian Randomization Study.
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato & Lagerberg, Trine Vik [Show all 10 contributors for this article] (2020). Is early debut of substance use Associated With violent offending in schizophrenia? Schizophrenia Bulletin. ISSN 0586-7614. 46. doi: 10.1093/schbul/sbaa028.055.
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato & Lagerberg, Trine Vik [Show all 10 contributors for this article] (2020). Is early debut of substance use Associated With violent offending in schizophrenia?
• Johnsen, Erik; Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Årsland, Dag & Malt, Eva Albertsen (2020). Psykofarmakologisk behandling av psykiske lidelser, Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S. ISSN 978-82-05-52662-4. p. 467–502.
• Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing & Pardiñas, Antonio F. [Show all 360 contributors for this article] (2019). Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4). Nature Genetics. ISSN 1061-4036. 51(6). doi: 10.1038/s41588-019-0435-6.
• Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel & Abé, Christoph [Show all 59 contributors for this article] (2019). Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals (Neuropsychopharmacology, (2019), 44, 13, (2285-2293), 10.1038/s41386-019-0485-6). Neuropsychopharmacology. ISSN 0893-133X. 44(13). doi: 10.1038/s41386-019-0521-6.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin & Savage, Jeanne [Show all 15 contributors for this article] (2019). Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence (Molecular Psychiatry, (2019), 10.1038/s41380-018-0332-x). Molecular Psychiatry. ISSN 1359-4184. 25(4), p. 914–914. doi: 10.1038/s41380-019-0456-7.
• Pardiñas, Antonio F.; Holmans, Peter A.; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Show all 144 contributors for this article] (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2). Nature Genetics. ISSN 1061-4036. 51(7). doi: 10.1038/s41588-019-0450-7.
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Show all 222 contributors for this article] (2019). Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x). Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10160-w.
• Rongve, Arvid; Witoelar, Aree Widya; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla & Clarimon, Jordi [Show all 40 contributors for this article] (2019). Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study (Scientific Reports, (2019), 9, 1, (7013), 10.1038/s41598-019-43458-2). Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-51827-0.
• Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
• Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking in Children with Suspected or Diagnosed Autism Spectrum Disorder .
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Tidlig motorikk og sammenheng med grad av autismesymptomer blant norske barn utredet for mistenkt autismespekterforstyrrelse (ASF).
• Tesli, Martin Steen; Corfield, Elizabeth; Zayats, Tetyana; Ask, Helga; Askeland, Ragna Bugge & Hannigan, Laurie [Show all 10 contributors for this article] (2019). Investigation of shared genetic risk between cardiometabolic morbidity and ADHD in a Norwegian family cohort using polygenic transmission disequilibrium test.
• Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth & Andreassen, Ole Andreas [Show all 9 contributors for this article] (2019). Early manifestations of genetic risk for neurodevelopmental disorders.
• Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen & Lagerberg, Trine Vik [Show all 12 contributors for this article] (2018). Affective lability and polygenic risk in bipolar disorder.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Show all 11 contributors for this article] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan & Melle, Ingrid [Show all 61 contributors for this article] (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. ISSN 1832-4274. 21(5), p. 394–397. doi: 10.1017/thg.2018.46.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E. & Watanabe, Kyoko [Show all 14 contributors for this article] (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence .
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas & Melle, Ingrid [Show all 7 contributors for this article] (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research. ISSN 0920-9964. 199, p. 433–435. doi: 10.1016/j.schres.2018.03.011.
• Smoller, Jordan W.; Andreassen, Ole Andreas; Edenberg, Howard J.; Faraone, Stephen V.; Glatt, Stephen J. & Kendler, Kenneth S. (2018). Correction to: Psychiatric genetics and the structure of psychopathology. Molecular Psychiatry. ISSN 1359-4184. p. 1–1. doi: 10.1038/s41380-018-0026-4.
• Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology. ISSN 0306-5251. 84(7), p. 1624–1625. doi: 10.1111/bcp.13606.
• Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen & Corfield, Elizabeth [Show all 12 contributors for this article] (2020). Early manifestations of genetic risk for neurodevelopmental disorders. PsyArXiv (Preprint artikkel).
• Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth & Ayorech, Ziada [Show all 14 contributors for this article] (2020). Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders. PsyArXiv (Preprint artikkel).

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