Ole Andreassen

2013 -  Director Centre of Excellence NORMENT, Professor, University of Oslo
2006 -  Attending psychiatrist (20 %), Outpatient clinic, Oslo University Hospital
2020 -  Co-director KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo

Previous: 

2012-2018: Director KG Jebsen Centre for Psychosis Research
2011-2012: Visiting Professor, UCSD, USA
2005-2011: Professor in Psychiatry, University of Oslo; Attending Psychiatrist, Oslo University Hospital
2001-2005: Combined position Resident Psychiatry, Oslo University Hospital - Ullevål; Senior Scientist, University of Oslo
2000-2001: Resident Dept. of Psychiatry, Oslo University Hospital - Ullevål
1998-2000: Post Doc, Massachusetts General Hospital, Harvard Medical School, USA
1996-1998: Internship Dept. of Surgery, Internal Medicine, Family Medicine, Stavanger University Hospital, Norway
1993-1996: PhD Research Fellow, Dept. of Physiology, University of Bergen, Norway

Editorial Board: Schizophr Bull, Acta Psych Scand, W J Biol Psych Eur J Pharmacol, Acta Neuropsychiatrica.

Ad hoc referee: New Engl J Med, Nat Genet, Nat Med, Nat Commun, Lancet, BMJ, PNAS, Mol Psychiatry, JCI, Am J Psychiatry, JAMA Psychiatry, Biol Psychiatry, Schizophr Bull, Transl Psych, Neuropsychopharmacology, J Clin Psychiatry, Schizophr Res, Prog Neurobiol, J Psych Res, Int J Neuropharm, Pharmacogenom J, Cereb Cortex, Neurobiol Dis, J Neurochem, J Psych Neurosci, J Affect Disord, Neuromolecular Med.

Grant review: Canadian Medical Research Council (RC), Neurological Foundation New Zealand, RC of Spain, AERES France, ANR France, Faroe Island RC, Irish RC, BBSRC, Austrian RC, Wellcome Trust, UPEC, MRC, EU ERA-NET, Dutch RC, Swiss RC, Swedish RC, Danish RC, German RC, Univ. Lyon, Univ. Copenhagen, Karolinska Inst., Oslo Univ. Hospital, West Norway Health Region, ERC Starting Grants, Northern Norway Health Region, Univ Montpellier HCERES.

Promotions: Univ. Copenhagen, Univ. Pittsburgh, Duke Univ., UCSD, Karolinska Inst., Univ. Bergen, Norwegian Univ. Science Technology, Univ. Helsinki, Univ Aarhus, South Africa RC, UCSF, UCL

PhD adjudication: Univ. Bergen 3, NTNU 3, Univ. Copenhagen 3, Univ. Gothenburg 1, Karolinska Inst. 1, Univ. Oslo 2. Lausanne Univ: 1, Univ Basel 1

RESEARCH LEADERSHIP, ADMIN. EXPERIENCE

1.    Hibar DP, Westlye LT, .., Andreassen OA. Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry. 2016 Feb 9  21 (12), 1710. | 
2.    Lo MT, Hinds DA, .., Andreassen OA, CH Chen. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat Genet 2017;49(1):152-6.
3.    Hibar DP, Westlye LT, .., Andreassen OA. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018;23(4):932-942. 
4.    Smeland OB, Bahrami S, Frei O, .., Dale AM, Andreassen OA. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry. 2019. 
5.    Stahl EA, Breen G, .., Andreassen OA, Kelsoe J, Sklar P.  Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019 May;51(5):793-803. 
6.    Sønderby IE, .., Andreassen OA. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2019 Jan 31 
7.    Jansen IE, .., Andreassen OA*, Posthuma D*. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat Genet. 2019 Mar;51(3):404-413. 
8.    O'Connell KS, Shadrin A, .., Andreassen OA. Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment. Biol Psychiatry. 2019 Nov 29.
9.    O'Connell KS, Shadrin A, .., Andreassen OA. Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Mol Psychiatry. 2019 Dec 2. 
10.     Bahrami S, Steen NE, .., Andreassen OA. Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study. JAMA Psychiatry. 2020 Jan 8.

• Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan & Szabo, Attila (2021). Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia. Brain, behavior, and immunity.  ISSN 0889-1591. . doi: 10.1016/j.bbi.2021.01.037 Full text in Research Archive.
• Bahrami, Shahram; Shadrin, Alexey A.; Frei, Oleksandr; O`Connell, Kevin; Bettella, Francesco; Krull, Florian; Fan, Chun Chieh; Røssberg, Jan Ivar; Hindley, Guy Frederick Lanyon; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Steen, Nils Eiel; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2021). Genetic loci shared between major depression and intelligence with mixed directions of effect. Nature Human Behaviour.  ISSN 2397-3374.  s 1- 9 . doi: 10.1038/s41562-020-01031-2
• Barth, Claudia; Nerland, Stener; de Lange, Ann-Marie Glasø; Wortinger, Laura Anne; Hilland, Eva; Andreassen, Ole Andreas; Jørgensen, Kjetil Nordbø & Agartz, Ingrid (2021). In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders. Schizophrenia Bulletin.  ISSN 0586-7614. . doi: https://doi.org/10.1093/schbul/sbaa192 Full text in Research Archive.
• Bigseth, Therese Torgersen; Fredriksen, Mats; Egeland, Jens; Andersen, Eivind; Andreassen, Ole Andreas; Bang-Kittilsen, Gry; Falk, Ragnhild Sørum; Holmen, Tom Langerud; Martinsen, Egil Wilhelm; Mordal, Jon; Nielsen, Jimmi; Steen, Nils Eiel; Ueland, Thor; Vang, Torkel & Engh, John (2021). Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia: A case-control study. Schizophrenia Research.  ISSN 0920-9964.  228, s 190- 192 . doi: 10.1016/j.schres.2020.11.051
• de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S.; Akkouh, Ibrahim; Hughes, Timothy; Frei, Evgeniia; Andreassen, Ole Andreas & Djurovic, Srdjan (2021). Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder. Cells.  ISSN 2073-4409.  10(2) . doi: 10.3390/cells10020209 Full text in Research Archive.
• Ditmars, Hillary L.; Logue, Mark W.; Toomey, Rosemary; McKenzie, Ruth E.; Franz, Carol E.; Panizzon, Matthew S.; Reynolds, Chandra A.; Cuthbert, Kristy N.; Vandiver, Richard; Gustavson, Daniel E.; Eglit, Graham M. L.; Elman, Jeremy A.; Sanderson-Cimino, Mark; Williams, McKenna E.; Andreassen, Ole Andreas; Dale, Anders M.; Eyler, Lisa T.; Fennema-Notestine, Christine; Gillespie, Nathan A.; Hauger, Richard L.; Jak, Amy J.; Neale, Michael C.; Tu, Xin M.; Whitsel, Nathan; Xian, Hong; Kremen, William S. & Lyons, Michael J. (2021). Associations between depression and cardiometabolic health: A 27-year longitudinal study. Psychological Medicine.  ISSN 0033-2917.  s 1- 11 . doi: 10.1017/S003329172000505X
• Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth; Lennox, Ziada Ayorech; Helgeland, Øyvind; Magnus, Per; Njølstad, Pål Rasmus; Øyen, Anne-Siri; Stoltenberg, Camilla; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted & Havdahl, Alexandra (2021). Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population. Schizophrenia Bulletin.  ISSN 0586-7614.
• Kessing, Lars Vedel; Gonzalez-Pinto, Ana; Fagiolini, Andrea; Bechdolf, Andreas; Reif, Andreas; Yildiz, Ayşegül; Etain, Bruno; Henry, Chantal; Severus, Emanuel; Reininghaus, Eva Z.; Morken, Gunnar; Goodwin, Guy M.; Scott, Jan; Geddes, John R.; Rietschel, Marcella; Landén, Mikael; Manchia, Mirko; Bauer, Michael; Martinez-Cengotitabengoa, Monica; Andreassen, Ole Andreas; Ritter, Philipp; Kupka, Ralph; Licht, Rasmus W.; Nielsen, René E.; Schulze, Thomas G.; Hajek, Tomas; Lagerberg, Trine Vik; Bergink, Veerle & Vieta, Eduard (2021). DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis – A narrative review from the ECNP bipolar disorders network. European Neuropsychopharmacology.  ISSN 0924-977X.  s 1- 8 . doi: 10.1016/j.euroneuro.2021.01.097
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2021). Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD). Journal of Autism and Developmental Disorders.  ISSN 0162-3257.  s 1- 19 . doi: 10.1007/s10803-020-04853-1 Full text in Research Archive. Show summary

  Pragmatic language impairments are common in neurodevelopmental disorders, especially in autism spectrum disorder (ASD). The relationship between structural language skills and pragmatic competence in children with autistic symptoms, however, is largely unknown. We investigated this relationship based on the Children’s Communication Checklist-2 and early language delay among children (N = 177, 19% females) clinically evaluated for ASD, differentiated into ASD (n = 148) and non-ASD (n = 29). Structural language deficits were common and associated with reduced pragmatic competence in both groups. Pragmatic language impairments were most profound in children with ASD. Early language delay and structural language deficits were less common in females. Our findings suggest that assessment of structural language skills should be included in the evaluation of children with suspected ASD.

• Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry.  ISSN 2158-3188.  11(1) . doi: 10.1038/s41398-021-01313-x Full text in Research Archive. Show summary

  Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Using independent component analysis, we decomposed self-report mental health questionnaires from 136,678 healthy individuals of the UK Biobank, excluding data from individuals with a diagnosed neurological or psychiatric disorder, into 13 distinct profiles relevant to mental health, capturing different symptoms as well as social and risk factors underlying reduced mental health. Utilizing genotypes from 117,611 of those individuals with White British ancestry, we performed GWAS for each mental health profile and assessed genetic correlations between these profiles, and between the profiles and common psychiatric disorders and cognitive traits. We found that mental health profiles were genetically correlated with a wide range of psychiatric disorders and cognitive traits, with strongest effects typically observed between a given mental health profile and a disorder for which the profile is common (e.g. depression symptoms and major depressive disorder, or psychosis and schizophrenia). Strikingly, although the profiles were phenotypically uncorrelated, many of them were genetically correlated with each other. This study provides evidence that statistically independent mental health profiles partly share genetic underpinnings and show genetic overlap with psychiatric disorders, suggesting that shared genetics across psychiatric disorders cannot be exclusively attributed to the known overlapping symptomatology between the disorders.

• Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel & Andreassen, Ole Andreas (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry.  ISSN 2158-3188.  11(1) . doi: 10.1038/s41398-020-01142-4 Full text in Research Archive. Show summary

  Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.

• Smelror, Runar; Johannessen, Cecilie Haggag; Wedervang-Resell, Kirsten; Jørgensen, Kjetil Nordbø; Barth, Claudia; Andreou, Dimitrios; Ueland, Torill; Andreassen, Ole Andreas; Myhre, Anne Margrethe; Rund, Bjørn Rishovd & Agartz, Ingrid (2021). Cognitive Impairment Profile in Adolescent Early-Onset Psychosis Usingthe MATRICS Battery: Age and Sex Effects. Neuropsychology.  ISSN 0894-4105.  35(3), s 300- 309 . doi: https://doi.org/10.1037/neu0000723
• Wisting, Line Norøm; Johnson, Sverre Urnes; Bulik, Cynthia M.; Andreassen, Ole Andreas; Rø, Øyvind & Bang, Lasse (2021). Psychometric properties of the Norwegian version of the Patient Health Questionnaire-9 (PHQ-9) in a large female sample of adults with and without eating disorders. BMC Psychiatry.  ISSN 1471-244X.  21:6, s 1- 11 . doi: 10.1186/s12888-020-03013-0 Full text in Research Archive.
• Wortinger, Laura Anne; Jørgensen, Kjetil Nordbø; Barth, Claudia; Nerland, Stener; Smelror, Runar; Vaskinn, Anja; Ueland, Torill; Andreassen, Ole Andreas & Agartz, Ingrid (2021). Significant association between intracranial volume and verbal intellectual abilities in patients with schizophrenia and a history of birth asphyxia. Psychological Medicine.  ISSN 0033-2917. . doi: https://doi.org/10.1017/S0033291721000489 Full text in Research Archive.
• Aas, Monica; Ueland, Torill; Inova, Amina; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder. Frontiers in Psychiatry.  ISSN 1664-0640. . doi: 10.3389/fpsyt.2020.00391 Full text in Research Archive.
• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila & Djurovic, Srdjan (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, behavior, and immunity.  ISSN 0889-1591.  87, s 634- 644 . doi: 10.1016/j.bbi.2020.02.008 Full text in Research Archive.
• Aminihajibashi, Samira; Hagen, Thomas; Andreassen, Ole Andreas; Laeng, Bruno & Espeseth, Thomas (2020). The effects of cognitive abilities and task demands on tonic and phasic pupil sizes. Biological Psychology.  ISSN 0301-0511.  156 . doi: 10.1016/j.biopsycho.2020.107945 Full text in Research Archive.
• Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey A.; O`Connell, Kevin; Frei, Oleksandr; Bettella, Francesco; Wirgenes, Katrine Verena; Krull, Florian; Fan, Chun C.; Dale, Anders; Smeland, Olav Bjerkehagen; Djurovic, Srdjan & Andreassen, Ole Andreas (2020). Shared genetic loci between body mass index and major psychiatric disorders: A genome-wide association study. JAMA psychiatry.  ISSN 2168-6238.  77(5), s 503- 512 . doi: 10.1001/jamapsychiatry.2019.4188 Show summary

  IMPORTANCE People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown. OBJECTIVE To assess the extent of the overlap between the genetic architectures of MPDs and BMI and identify genetic loci shared between them. DESIGN, SETTING, AND PARTICIPANTS Using a conditional false discovery rate statistical framework, independent genome-wide association study data on individuals with SCZ (n = 82 315), BIP (n = 51 710), MD (n = 480 359), and BMI (n = 795 640) were analyzed. The UK Biobank cohort (n = 29 740) was excluded from the MD data set to avoid sample overlap. Data were collected from August 2017 to May 2018, and analysis began July 2018. MAIN OUTCOMES AND MEASURES The primary outcomes were a list of genetic loci shared between BMI and MPDs and their functional pathways. RESULTS Genome-wide association study data from 1 380 284 participants were analyzed, and the genetic correlation between BMI and MPDs varied (SCZ: r for genetic = −0.11, P = 2.1 × 10−10; BIP: r for genetic = −0.06, P = .0103; MD: r for genetic = 0.12, P = 6.7 × 10−10). Overall, 63, 17, and 32 loci shared between BMI and SCZ, BIP, and MD, respectively, were analyzed at conjunctional false discovery rate less than 0.01. Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate <0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways. CONCLUSIONS AND RELEVANCE In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones

• Bakke, Laura A Wortinger; Engen, Kristine; Barth, Claudia; Andreassen, Ole Andreas; Jørgensen, Kjetil Nordbø & Agartz, Ingrid (2020). Asphyxia at birth affects brain structure in patients on the schizophrenia-bipolar disorder spectrum and healthy participants. Psychological Medicine.  ISSN 0033-2917. . doi: 10.1017/S0033291720002779 Full text in Research Archive.
• Barth, Claudia; Lonning, Vera Louise Hiorth; Gurholt, Tiril Pedersen; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis.. PLOS ONE.  ISSN 1932-6203. . doi: 10.1371/journal.pone.0233684 Full text in Research Archive.
• Beck, Dani; de Lange, Ann-Marie Glasø; Maximov, Ivan; Richard, Geneviève; Andreassen, Ole Andreas; Nordvik, Jan E. & Westlye, Lars Tjelta (2020). White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction. NeuroImage.  ISSN 1053-8119.  224:117441, s 1- 14 . doi: 10.1016/j.neuroimage.2020.117441 Full text in Research Archive.
• Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir; Winterton, Adriano; Haram, Marit; Høegh, Margrethe Collier; Lagerberg, Trine Vik; Steen, Nils Eiel; Larsen, Lars; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  00:110108, s 1- 8 . doi: 10.1016/j.pnpbp.2020.110108 Full text in Research Archive.
• Bryois, Julien; Skene, Nathan G.; Hansen, Thomas Folkmann; Kogelman, Lisette J.A.; Watson, Hunna J.; Liu, Zijing; Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole Andreas; Baker, Jessica; Bergen, Andrew; Berrettini, Wade; Birgegård, Andreas; Boden, Joseph; Boehm, Ilka; Knudsen, Gun Peggy Strømstad; La Via, Maria C; Landén, Mikael; Larsen, Janne; Hellard, Stephanie Francoise Claire Le; Leppa, Virpi; Martin, Nicholas; Mattheisen, Manuel; Mattingsdal, Morten; McDevitt, Sara; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ripke, Stephan; Zipfel, Stephan; Antilla, Verneri; Artto, Ville; Belin, Andrea Carmine; de Boer, Irene; Boomsma, Dorret I.; Børte, Sigrid; Pedersen, Linda Margareth; Pedersen, Nancy; Posthuma, Danielle; Wessmann, Maija; Winsvold, Bendik K S; Zhao, Huiying; Zwart, John-Anker; Brueggeman, Leo; Breen, Gerome; Bulik, Cynthia M.; Arenas, Ernest; Hjerling-Leffler, Jens & Sullivan, Patrick F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics.  ISSN 1061-4036.  52, s 482- 493 . doi: 10.1038/s41588-020-0610-9
• Cheesman, Rosa; Eilertsen, Espen Moen; Ahmadzadeh, Yasmin I.; Gjerde, Line C.; Hannigan, Laurie John; Havdahl, Alexandra; Young, Alexander I.; Eley, Thalia C.; Njølstad, Pål Rasmus; Magnus, Per; Andreassen, Ole Andreas; Ystrøm, Eivind & McAdams, Tom A. (2020). How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa). BMC Medicine.  ISSN 1741-7015.  18 . doi: 10.1186/s12916-020-01760-1 Full text in Research Archive.
• Ching, Christopher R. K.; Hibar, Derrek P.; Gurholt, Tiril Pedersen; Nunes, Abraham; Thomopoulos, Sophia I.; Abé, Chritsoph; Agartz, Ingrid; Brouwer, Rachel M.; Cannon, Dara M.; de Zwarte, Sonja M. C.; Eyler, Lisa T.; Favre, Pauline; Hajek, Tomas; Haukvik, Unn Kristin H.; Houenou, Josselin; Zeng, Ling-Li; Almeida, Jorge; Alnæs, Dag; Alonso-Lana, Silvia; Altimus, Cara; Bauer, Michael; Baune, Bernhard T.; Bearden, Carrie E.; Bellani, Marcella; Benedetti, Francesco; Berk, Michael; Bilderbeck, Amy C.; Blumberg, Hilary P.; Bøen, Erlend; Bollettini, Irene; del Mar Bonnin, Caterina; Brambilla, Paolo; Díaz-Zuluaga, Ana M.; Dima, Danai; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Fears, Scott C.; Jansen, Andreas; Kircher, Tilo T.J.; Knochel, Christian; Krämer, Bernd; Tamnes, Christian Krog; Thomaidis, Georgios V.; Upegui, Cristian Vargas; Veltman, Dick J; Wessa, Michele; Westlye, Lars Tjelta; Whalley, Heather C.; Wolf, Daniel H.; Thompson, Paul M & Andreassen, Ole Andreas (2020). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping.  ISSN 1065-9471. . doi: https://doi.org/10.1002/hbm.25098 Full text in Research Archive.
• Coleman, Jonathan R.I.; Gaspar, Helena A; Bryois, Julien; Byrne, Enda M; Forstner, Andreas J; Holmans, Peter A; de Leeuw, Christiaan A.; Mattheisen, Manuel; McQuillin, Andrew; Whitehead Pavlides, Jennifer M; Pers, Tune H; Ripke, Stephan; Stahl, Eli A.; Steinberg, Stacy; Trubetskoy, Vassily; Trzaskowski, Maciej; Wang, Yunpeng; Abbott, Liam; Abdellaoui, Abdel; Adams, Mark J; Nordin Adolfsson, Annelie; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Andlauer, Till F.M.; Anjorin, Adebayo; Anttila, Verneri; Van Der Auwera, Sandra; Awasthi, Swapnil; Bacanu, Silviu-Alin; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Beekman, Aartjan T.F.; Belliveau, Richard; Bøen, Erlend; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Ødegaard, Ketil Joachim; Stordal, Eystein; Vaaler, Arne; Andreassen, Ole Andreas & Breen, Gerome (2020). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2019.10.015 Show summary

  Background: Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. Methods: To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). Results: Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder. Conclusions: The mood disorders share several genetic associations, and genetic studies of major depressive disorder and bipolar disorder can be combined effectively to enable the discovery of variants not identified by studying either disorder alone. However, we demonstrate several differences between these disorders. Analyzing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum.

• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 8 . doi: 10.1038/s41380-020-0664-1 Full text in Research Archive.
• Costa, Beatrice; Manzoni, Claudia; Bernal-Quiros, Manual; Kia, Demis A.; Aguilar, Miquel; Alvarez, Ignacio; Alvarez, Victoria; Andreassen, Ole Andreas; Anfossi, Maria; Bagnoli, Silvia; Benussi, Luisa; Bernardi, Livia; Binetti, Giuliano; Blackburn, Daniel; Boada, Mercè; Borroni, Barbara; Bowns, Lucy; Bråthen, Geir; Bruni, Amalia C; Chiang, Huei-Hsin; Clarimon, Jordi; Colville, Shuna; Conidi, Maria E; Cope, Tom E; Cruchaga, Carlos; Cupidi, Chiara; Di Battista, Maria Elena; Diehl-Schmid, Janine; Diez-Fairen, Monica; Dols-Icardo, Oriol; Durante, Elisabetta; Flisar, Dusan; Frangipane, Francesca; Galimberti, Daniela; Gallo, Maura; Gallucci, Mauricio; Ghidoni, Roberta; Graff, Caroline; Grafman, Jordan H; Grossman, Murray; Hardy, John; Hernández, Isabel; Holloway, Guy J T; Huey, Edward D; Illán-Gala, Ignacio; Karydas, Anna; Khoshnood, Behzad; Kramberger, Milica G.; Kristiansen, Mark K & Sando, Sigrid Botne (2020). C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts. Neurology.  ISSN 0028-3878.  95(24), s e3288- e3302 . doi: 10.1212/WNL.0000000000010914 Full text in Research Archive. Show summary

  Objective: We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases. Methods: We evaluated expansions frequency in the entire cohort (n = 1,396; behavioral variant frontotemporal dementia [bvFTD] [n = 800], primary progressive aphasia [PPA] [n = 495], and FTLD-motor neuron disease [MND] [n = 101]). We then focused on the bvFTD and PPA cases and tested for association between expansion status, syndromes, genetic ancestry, and AAO applying statistical tests comprising Fisher exact tests, analysis of variance with Tukey post hoc tests, and logistic and nonlinear mixed-effects model regressions. Results: We found C9orf72 pathogenic expansions in 4% of all cases (56/1,396). Expansion carriers differently distributed across syndromes: 12/101 FTLD-MND (11.9%), 40/800 bvFTD (5%), and 4/495 PPA (0.8%). While addressing population substructure through principal components analysis (PCA), we defined 2 patients groups with Central/Northern (n = 873) and Southern European (n = 523) ancestry. The proportion of expansion carriers was significantly higher in bvFTD compared to PPA (5% vs 0.8% [p = 2.17 × 10-5; odds ratio (OR) 6.4; confidence interval (CI) 2.31-24.99]), as well as in individuals with Central/Northern European compared to Southern European ancestry (4.4% vs 1.8% [p = 1.1 × 10-2; OR 2.5; CI 1.17-5.99]). Pathogenic expansions and Central/Northern European ancestry independently and inversely correlated with AAO. Our prediction model (based on expansions status, genetic ancestry, and AAO) predicted a diagnosis of bvFTD with 64% accuracy. Conclusions: Our results indicate correlation between pathogenic C9orf72 expansions, AAO, PCA-based Central/Northern European ancestry, and a diagnosis of bvFTD, implying complex genetic risk architectures differently underpinning the behavioral and language variant syndromes.

• Cuellar-Partida, Gabriel; Tung, Joyce Y; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole Andreas; Barroso, Inês; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I.; Boyd, Heather A.; Breteler, Monique M.B.; Campbell, Harry; Chasman, Daniel I.; Cherkas, Lynn; Davies, Gail; Geus, Eco JC de; Deary, Ian J.; Deloukas, Panos; Dick, Danielle M.; Duffy, David L.; Eriksson, Johan G.; Esko, Tõnu; Feenstra, Bjarke; Geller, Frank; Gieger, Christian; Giegling, Ina; Gordon, Scott D.; Han, Jiali; Hansen, Thomas F.; Hartmann, Annette M.; Hayward, Caroline; Heikkila, Kauko; Hicks, Andrew A.; Hirschhorn, Joel N.; Hottenga, Jouke-Jan; Huffman, Jennifer E.; Hwang, Liang-Dar; Ikram, M. Arfan; Kaprio, Jaakko; Kemp, John P.; Khaw, Kay-Tee; Klopp, Norman; Konte, Bettina; Kutalik, Zoltan; Lahti, Jari; Li, Xin; Loos, Ruth J.F.; Luciano, Michelle; O`Connell, Kevin & Medland, Sarah E (2020). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour.  ISSN 2397-3374. . doi: 10.1038/s41562-020-00956-y
• de Zwarte, Sonja M. C.; Brouwer, Rachel M; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Silvia; Bearden, Carrie E; Bertolino, Alessandro; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E. L.; Cahn, Wiepke; Canales‐Rodríguez, Erick J.; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro‐Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; de la Serna, Elena; del Mar Bonnin, Caterina; Demro, Caroline; Di Giorgio, Annabella; Doucet, Gaëlle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fatjó-Vilas, Mar; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goikolea, Jose M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hidiroglu Ongun, Ceren; Hillegers, Manon H.J.; Houenou, Josselin; Pol, Hilleke E. Hulshoff; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik Gunnar; Kane, Fergus; Andreassen, Ole Andreas & van Haren, Neeltje E. M. (2020). Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.25206 Full text in Research Archive.
• Delfin, Carl Mikael; Reckless, Greg; Bolstad, Ingeborg; Groote, Inge Rasmus; Andreassen, Ole Andreas & Jensen, Jimmy Kristian (2020). Exploring the effects of an acute dose of antipsychotic medication on motivation-mediated BOLD activity using fMRI and a perceptual decision-making task. Neuroscience.  ISSN 0306-4522.  440, s 146- 159 . doi: 10.1016/j.neuroscience.2020.05.035
• Drange, Ole Kristian; Sæther, Sverre Georg; Finseth, Per Ivar; Morken, Gunnar; Vaaler, Arne; Arntsen, Vibeke; Henning, Oliver Johannes; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn; Malt, Ulrik Fredrik & Bøen, Erlend (2020). Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study. BMC Psychiatry.  ISSN 1471-244X.  20 . doi: 10.1186/s12888-020-02968-4 Full text in Research Archive.
• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O`Connell, Kevin; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Sowa, Piotr; Soininen, Hilkka; Steen, Vidar Martin; Vellas, Bruno; Tsolaki, Magda; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-17376-1 Full text in Research Archive. Show summary

  Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

• Engen, Magnus Johan; Lyngstad, Siv Hege; Ueland, Torill; Simonsen, Carmen Elisabeth; Vaskinn, Anja; Smeland, Olav Bjerkehagen; Bettella, Francesco; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2020). Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls. Translational Psychiatry.  ISSN 2158-3188.  10:416, s 1- 9 . doi: 10.1038/s41398-020-01094-9 Full text in Research Archive.
• Fan, Chun Chieh; Banks, Sarah J.; Thompson, Wesley K.; Chen, Chi-Hua; McEvoy, Linda K.; Tan, Chin Hong; Kukull, Walter A.; Bennett, David A.; Farrer, Lindsay A.; Mayeux, Richard; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Desikan, Rahul S. & Dale, Anders (2020). Sex-dependent autosomal effects on clinical progression of Alzheimer's disease. Brain.  ISSN 0006-8950.  143(7), s 2272- 2280 . doi: 10.1093/brain/awaa164
• Feyer, Frida Karine; Andersson, Stein; Büchmann, Camilla Bakkalia; Melle, Ingrid; Andreassen, Ole Andreas & Vaskinn, Anja (2020). Social perception predicts awareness of illness in persons with schizophrenia. Journal of Nervous and Mental Disease.  ISSN 0022-3018.  208(9), s 701- 705 . doi: 10.1097/NMD.0000000000001185 Full text in Research Archive.
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, DP; Lind, Penelope A.; Pizzagalli, Fabrizio; Ching, Christopher R.K.; McMahon, Mary Agnes B.; Shatokhina, Natalia; Zsembik, Leo C.P.; Thomopoulos, Sophia I.; Zhu, Alyssa H.; Strike, Lachlan T.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Wolfers, Thomas; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Melle, Ingrid; Andreassen, Ole Andreas; Espeseth, Thomas; Jönsson, Erik Gunnar; Steen, Vidar Martin; Håberg, Asta; Trollor, Julian N.; Van Der Wee, Nic J.A.; Volzke, Henry; Walter, Henrik; Weber, Bernd; Weinberger, Daniel R.; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). The genetic architecture of the human cerebral cortex. Science.  ISSN 0036-8075.  367(6484) . doi: 10.1126/science.aay6690 Full text in Research Archive. Show summary

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• Gurholt, Tiril Pedersen; Lonning, Vera Louise Hiorth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Haukvik, Unn Kristin H.; Alloza, Clara; Arango, Celso; Barth, Claudia; Bearden, Carrie E.; Berk, Michael; Bohman, Hannes; Dandash, Orwa; Diaz-Caneja, Covadonga M.; Edbom, Carl T.; van Erp, Theo G.M.; Fett, Anne-Kathrin J.; Frangou, Sophia; Goldstein, Benjamin I; Grigorian, Anahit; Jahanshad, Neda; James, Anthony C.; Janssen, Joost; Johannessen, Cecilie Haggag; Karlsgodt, Katherine H. ; Kempton, Matthew J.; Kochunov, Peter; Krabbendam, Lydia; Kyriakopoulos, Marinos; Lundberg, Mathias; MacIntosh, Bradley J.; Rund, Bjørn Rishovd; Smelror, Runar; Sultan, Alysha; Tamnes, Christian Krog; Thomopoulos, Sophia I.; Vajdi, Ariana; Wedervang-Resell, Kirsten; Myhre, Anne Margrethe; Andreassen, Ole Andreas; Thompson, Paul M. & Agartz, Ingrid (2020). Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium. Human Brain Mapping.  ISSN 1065-9471.  s 1- 12 . doi: 10.1002/hbm.25212 Full text in Research Archive.
• Halle, Kari Krizak; Bakke, Øyvind; Djurovic, Srdjan; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Andreassen, Ole Andreas & Langaas, Mette (2020). Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models. Scandinavian Journal of Statistics.  ISSN 0303-6898.  47(4) . doi: 10.1111/sjos.12451 Full text in Research Archive.
• Han, Laura KM; Dinga, Richard; Hahn, Tim; Ching, Christopher R. K.; Eyler, Lisa T.; Aftanas, Lyubomir; Aghajani, Moji; Aleman, André; Baune, Bernhard T.; Berger, Klaus; Brak, Ivan; Busatto, Geraldo F.; Carballedo, Angela; Connolly, Colm G.; Couvy-Duchesne, Baptiste; Cullen, Kathryn R.; Alda, Martin; Abé, Christoph; Andreassen, Ole Andreas; Bøen, Erlend; Bonnín, Caterina M.; Canales-Rodriguez, Erick J.; Cannon, Dara; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Elvsåshagen, Torbjørn; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Goikolea, Jose M.; Haarman, Bartholomeus C.M.; Hajek, Tomas; Henry, Chantal; Houenou, Josselin; Howells, Fleur M.; Ingvar, Martin; Kuplicki, Rayus; Lafer, Beny; Landen, Mikael; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Nabulsi, Leila; Thompson, Paul M.; Veltman, Dick J.; Penninx, Brenda W.J.H.; Marquand, André F.; Cole, James H. & Schmaal, Lianne (2020). Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-020-0754-0 Full text in Research Archive.
• Haukvik, Unn Kristin H.; Gurholt, Tiril Pedersen; Nerland, Stener; Elvsåshagen, Torbjørn; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T.; Benedetti, Francesco; Berk, Michael; Bettella, Francesco; Bøen, Erlend; Bonnín, Caterina M.; Brambilla, Paolo; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M.; van Erp, Theo G.M.; Fatjó-Vilas, Mar; Foley, Sonya F.; Förster, Katharina; Fullerton, Janice M.; Goikolea, Jose M.; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C. M.; Haatveit, Beathe; Hajek, Tomas; Hallahan, Brian; Harris, Mathew; Hawkins, Emma L.; Howells, Fleur M.; Hülsmann, Carina; Jahanshad, Neda; Jørgensen, Kjetil Nordbø; Kircher, Tilo; Krämer, Bernd; Krug, Axel; Kuplicki, Rayus; Lagerberg, Trine Vik; Lancaster, Thomas M.; Lenroot, Rhoshel K.; Lonning, Vera Louise Hiorth; López-Jaramillo, Carlos; Malt, Ulrik Fredrik; McDonald, Colm; McIntosh, Andrew M.; McPhilemy, Genevieve; van der Meer, Dennis; Melle, Ingrid; Melloni, Elisa M. T.; Mitchell, Philip B.; Nabulsi, Leila; Nenadic, Igor; Oertel, Viola; Oldani, Lucio; Opel, Nils; Otaduy, Maria C. G.; Overs, Bronwyn; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Radua, Joaquim; Rauer, Lisa; Redlich, Ronny; Repple, Jonathan; Rive, Maria M.; Roberts, Gloria; Ruhe, Henricus G.; Salminen, Lauren E.; Salvador, Raymond; Sarró, Salvador; Savitz, Jonathan; Schene, Aart H.; Sim, Kang; Soeiro-de-Souza, Marcio G.; Stäblein, Michael; Stein, Dan J.; Stein, Frederike; Tamnes, Christian Krog; Temmingh, Henk S.; Thomopoulos, Sophia I.; Veltman, Dick J.; Vieta, Eduard; Waltemate, Lena; Westlye, Lars Tjelta; Whalley, Heather C.; Sämann, Philipp G.; Thompson, Paul M.; Ching, Christopher; Andreassen, Ole Andreas & Agartz, Ingrid (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping.  ISSN 1065-9471.  s 1- 14 . doi: 10.1002/hbm.25249 Full text in Research Archive.
• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Werner, Maren Caroline Frogner; Melle, Ingrid; Andreassen, Ole Andreas; Lagerberg, Trine Vik; Steen, Nils Eiel & Haukvik, Unn Kristin H. (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior.  ISSN 2162-3279.  10(9) . doi: 10.1002/brb3.1751 Full text in Research Archive.
• Hjelseng, Ingrid Varvin; Vaskinn, Anja; Ueland, Torill; Lunding, Synve Hoffart; Reponen, Elina Johanna; Steen, Nils Eiel; Andreassen, Ole Andreas & Aas, Monica (2020). Childhood Trauma Is Associated With Poorer Social Functioning in Severe Mental Disorders Both During an Active Illness Phase and in Remission. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2020.03.015
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications.  ISSN 2041-1723.  11 . doi: 10.1038/s41467-020-18367-y Full text in Research Archive.
• Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Sundar, Vijay S.; Thompson, Paul; Andreassen, Ole Andreas & Dale, Anders M. (2020). Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. PLoS Genetics.  ISSN 1553-7390. . doi: 10.1371/journal.pgen.1008612 Full text in Research Archive.
• Holleran, Laurena; Kelly, Sinead; Alloza, Clara; Agartz, Ingrid; Andreassen, Ole Andreas; Arango, Celso; Banaj, Nerisa; Calhoun, Vince; Cannon, Dara; Carr, Vaughan; Corvin, Aiden; Glahn, David C.; Gur, Ruben; Hong, Elliot; Hoschl, Cyril; Howells, Fleur M.; James, Anthony; Janssen, Joost; Kochunov, Peter; Lawrie, Stephen M.; Liu, Jingyu; Martinez, Covadonga; McDonald, Colm; Morris, Derek; Mothersill, David; Pantelis, Christos; Piras, Fabrizio; Potkin, Steven; Rasser, Paul E.; Roalf, David; Rowland, Laura; Satterthwaite, Theodore D.; Schall, Ulrich; Spalletta, Gianfranco; Spaniel, Filip; Stein, Dan J.; Uhlmann, Anne; Voineskos, Aristotle; Zalesky, Andrew; Van Erp, Theo G.M.; Turner, Jessica A.; Deary, Ian J.; Thompson, Paul M.; Jahanshad, Neda & Donohoe, Gary (2020). The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium. American Journal of Psychiatry.  ISSN 0002-953X. . doi: 10.1176/appi.ajp.2019.19030225
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva; Abrahamsen, Tore G; Nerhus, Mari; Wedervang-Resell, Kirsten; Lonning, Vera Louise Hiorth; Johannessen, Jarle; Steen, Nils Eiel; Agartz, Ingrid; Stenberg, Nina; Hundhausen, Thomas Eckhard; Mørkrid, Lars & Andreassen, Ole Andreas (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal.  ISSN 0892-6638.  34(6), s 8114- 8124 . doi: 10.1096/fj.201900855RRR
• Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Walsh, Eleanor I.; Turner, Emma; Lane, J. Athene; Martin, Richard M.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Parsons, J. Kellogg; Eeles, Rosalind A.; Easton, Douglas F.; Kote-Jarai, Zsofia; Olama, Ali Amin Al; Garcia, Sara Benlloch; Muir, Kenneth; Grönberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; Tammela, Teuvo L.J.; Nordestgaard, Børge Grønne; Key, Timothy J.; Travis, Ruth C.; Pharoah, Paul D.P.; Pashayan, Nora; Khaw, Kay-Tee; Brenner, Hermann; Schottker, Ben; Holleczek, Bernd; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Slavov, Chavdar; Kaneva, Radka P.; Mitev, Vanio I.; Batra, Jyotsna; Clements, Judith A.; Spurdle, Amanda B.; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Mills, Ian G; Andreassen, Ole Andreas; Dale, Anders M. & Seibert, Tyler M. (2020). A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965. . doi: 10.1158/1055-9965.Epi-19-1527
• Huynh-Le, Minh-Phuong; Myklebust, Tor Åge; Feng, Christine; Karunamuni, Roshan; Johannesen, Tom Børge; Dale, Anders M; Andreassen, Ole Andreas & Seibert, Tyler M. (2020). Age dependence of modern clinical risk groups for localized prostate cancer-A population-based study. Cancer.  ISSN 0008-543X.  126(8), s 1691- 1699 . doi: 10.1002/cncr.32702
• Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton; Makarious, Mary B.; Kim, Jonggeol J.; Liu, Ganqiang; Maple-Grødem, Jodi; Corvol, Jean-Christophe; Pihlstrøm, Lasse; van Nimwegen, Marlies; Smolensky, Luba; Amondikar, Ninad; Hutten, Samantha J.; Frasier, Mark; Nguyen, Khanh-Dung H.; Rick, Jacqueline; Eberly, Shirley; Faghri, Faraz; Auinger, Peggy; Scott, Kirsten M.; Wijeyekoon, Ruwani; Van Deerlin, Vivianna M.; Hernandez, Dena G.; Gibbs, Raphael; Day-Williams, Aaron G.; Brice, Alexis; Alves, Guido Werner; Noyce, Alastair J.; Tysnes, Ole-Bjørn; Evans, Jonathan R.; Breen, David P.; Estrada, Karol; Wegel, Claire E.; Danjou, Fabrice; Simon, David K.; Andreassen, Ole Andreas; Ravina, Bernard; Toft, Mathias; Heutink, Peter; Bloem, Bastiaan R.; Weintraub, Daniel; Barker, Roger A.; Williams-Gray, Caroline H.; van de Warrenburg, Bart P.; van Hilten, Jacobus J.; Scherzer, Clemens R.; Singleton, Andrew B. & Nalls, Mike A. (2020). Differences in the presentation and progression of Parkinson's disease by sex. Movement Disorders.  ISSN 0885-3185.  s 1- 14 . doi: 10.1002/mds.28312
• Kamitaki, Nolan; Sekar, Aswin; Handsaker, Robert E; de Rivera,, Heather; Tooley,, Katherine; Morris,, David L.; Taylor, Kimberly E.; Whelan, Christopher W.; Tombleson, Philip; Olde Loohuis,, Loes M.; Boehnke, Michael; Kimberly, Robert P.; Kaufman, Kenneth M.; Harley, John B.; Langefeld, Carl D.; Seidman, Christine E.; Pato, Michele T.; Pato, Carlos N.; Ophoff, Roel A.; Graham, Robert R.; Criswell, Lindsey A.; McCarroll, Steven A.; Vyse, Timothy J.; Schizophrenia, Working Group of; Ripke, Stephan; Neale, Benjamin M.; Corvin, Aiden; Andreassen, Ole Andreas; Walters, James T. R.; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Huang, Hailiang; Collier, David A.; Pers, Tune H.; Farh, Kai-How; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Bruggeman, Richard; Amin, Farooq; Bigdeli, Tim B.; Black, Donald W.; Bevilacqua, Elizabeth; Bergen, Sarah E.; Alexander, Madeline; Bene, Judit; Belliveau Jr, Richard A.; Bacanu, Silviu A. & Buccola, Nancy G. (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature.  ISSN 0028-0836. . doi: 10.1038/s41586-020-2277-x
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun C.; Eeles, Rosalind A; Easton, Douglas F; Kote-Jarai, ZSofia; Al Olama, Ali Amin; Garcia, Sara Benlloch; Muir, Kenneth; Gronberg,, Henrik; Wiklund,, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; Tammela,, Teuvo L. J; Nordestgaard, Børge G; Key, Tim J.; Travis, Ruth C; Neal, David E.; Donovan, Jenny L; Hamdy, Freddie C; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Thibodeau, Stephen N; McDonnell, Shannon K.; Schaid, Daniel J.; Maier, Christiane; Luedeke, Manuel; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Schottker, Ben; Holleczek, Bernd; Park, Jong Y; Sellers, Thomas A.; Lin, Hui-Yi; Slavov, Chavdar; Mitev, Vanio; Batra, Jyotsna; Clements, Judith A.; Kaneva, Radka; Spurdle, Amanda; Prostate Cancer Bio, Australian; Walther, Vogel,; Herkommer, Kathleen; Teixeira, Manuel R.; Paulo, Paula; Hardev Pandha, Sofia Maia; Michael, Agnieszka; Mills, Ian G; Andreassen, Ole Andreas; Dale, Anders M.; Seibert, Tyler M. & PRACTICAL Consortium, The (2020). The effect of sample size on polygenic hazard models for prostate cancer. European Journal of Human Genetics.  ISSN 1018-4813. . doi: 10.1038/s41431-020-0664-2
• Karunamuni, Roshan A.; Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Thompson, Wesley K.; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Lophatananon, Artitaya; Tangen, Catherine M.; Goodman, Phyllis J.; Thompson, Ian M.; Blot, William J.; Zheng, Wei; Kibel, Adam S.; Drake, Bettina F.; Cussenot, Olivier; Cancel-Tassin, Geraldine; Menegaux, Florence; Truong, Thérèse; Park, Jong Y.; Lin, Hui-Yi; Bensen, Jeanette T.; Fontham, Elizabeth T. H.; Mohler, James L.; Taylor, Jack A.; Multigner, Luc; Blanchet, Pascal; Brureau, Laurent; Romana, Marc; Leach, Robin J.; John, Esther M.; Fowke, Jay; Bush, William S; Aldrich, Melinda C.; Crawford, Dana C.; Srivastava, Shiv; Cullen, Jennifer C.; Petrovics, Gyorgy; Parent, Marie-Élise; Hu, Jennifer J.; Sanderson, Maureen; Mills, Ian Geoffrey; Andreassen, Ole Andreas; Dale, Anders M. & Seibert, Tyler M. (2020). African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. International Journal of Cancer.  ISSN 0020-7136. . doi: 10.1002/ijc.33282
• Kia, Seyed Mostafa; Huijsdens, Hester; Dinga, Richard; Wolfers, Thomas; Mennes, Maarten; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Beckmann, Christian F. & Marquand, Andre (2020). Hierarchical bayesian regression for multi-site normative modeling of neuroimaging data. Lecture Notes in Computer Science (LNCS).  ISSN 0302-9743.  12267, s 699- 709 . doi: 10.1007/978-3-030-59728-3_68
• Kochunov, Peter; Hong, Elliot; Dennis, Emily L; Morey, Rajendra A.; Tate, David F.; Logue, Mark W.; Kelly, Sinead; Donohoe, Gary; Pauline, Favre; Houenou, Josselin; Ching, Christopher R. K.; Holleran, Laurena; Andreassen, Ole Andreas; Velzen, Laura S. van; Schmaal, Lianne; Villalón‐Reina, Julio E.; Bearden, Carrie E.; Piras, Fabrizio; Spalletta, Gianfranco; van den Heuvel, Odile A.; Veltman, Dick J.; Stein, Dan J.; Ryan, Meghann C.; Tan, Yunlong; van Erp, Theo G. M.; Turner, Jessica A.; Haddad, Liz; Nir, Talia M.; Glahn, David C.; Thompson, Paul M. & Jahanshad, Neda (2020). ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.24998 Full text in Research Archive.
• Koenig, Julian; Abler, Birgit; Agartz, Ingrid; Åkerstedt, Torbjørn; Andreassen, Ole Andreas; Anthony, Mia; Bär, Karl-Jürgen; Bertsch, Katja; Brown, Rebecca C.; Brunner, Romuald; Carnevali, Luca; Critchley, Hugo D.; Cullen, Kathryn R.; De Geus, Eco J C; de la Cruz, Feliberto; Dziobek, Isabel; Ferger, Marc D.; Fischer, Håkan; Flor, Herta; Gaebler, Michael; Gianaros, Peter J; Giummarra, Melita J.; Greening, Steven G.; Guendelman, Simon; Heathers, James A. J.; Herpertz, Sabine C.; Hu, Mandy X.; Jentschke, Sebastian; Kaess, Michael; Kaufmann, Tobias; Klimes-Dougan, Bonnie; Koelsch, Stefan; Krauch, Marlene; Kumral, Deniz; Lamers, Femke; Lee, Tae-Ho; Lekander, Mats; Lin, Feng; Lotze, Martin; Makovac, Elena; Mancini, Matteo; Mancke, Falk; Månsson, Kristoffer N. T.; Manuck, Stephen B.; Mather, Mara; Meeten, Frances; Min, Jungwon; Mueller, Bryon A.; Muench, Vera; Nees, Frauke; Nga, Lin; Nilsonne, Gustav; Ordonez Acuna, Daniela; Osnes, Berge; Ottaviani, Cristina; Penninx, Brenda; Ponzio, Allison; Poudel, Govinda R.; Reinelt, Janis; Ren, Ping; Sakaki, Michiko; Schumann, Andy; Sørensen, Lin; Specht, Karsten; Straub, Joana; Tamm, Sandra; Thai, Michelle; Thayer, Julian F.; Ubani, Benjamin; van der Mee, Denise J.; van Velzen, Laura S.; Ventura-Bort, Carlos; Villringer, Arno; Watson, David R.; Wei, Luqing; Wendt, Julia; Schreiner, Melinda Westlund; Westlye, Lars Tjelta; Weymar, Mathias; Winkelmann, Tobias; Wu, Guo-Rong; Yoo, Hyun Joo & Quintana, Daniel (2020). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology.  ISSN 0048-5772. . doi: 10.1111/psyp.13688 Full text in Research Archive. Show summary

  Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

• Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia.  ISSN 2334-265X.  6 . doi: 10.1038/s41537-020-0107-7 Full text in Research Archive.
• Leerssen, Jeanne; Blanken, Tessa F.; Pozzi, Elena; Jahanshad, Neda; Aftanas, Lyubomir; Andreassen, Ole Andreas; Baune, Bernhard T.; Brack, Ivan; Carballedo, Angela; Ching, Christopher; Dannlowski, Udo; Dohm, Katharina; Enneking, Verena; Filimonova, Elena; Fingas, Stella M.; Frodl, Thomas; Godlewska, Beata; Goltermann, Janik; Gotlib, Ian H.; Grotegerd, Dominik; Gruber, Oliver; Harris, Mathew A.; Hatton, Sean N.; Hawkins, Emma L.; Hickie, Ian B.; Jaworska, Natalia; Kircher, Tilo; Krug, Axel; Lagopoulos, Jim; Lemke, Hannah; Li, Meng; MacMaster, Frank P.; McIntosh, Andrew M.; McLellan, Quinn; Meinert, Susanne; Mwangi, Benson; Nenadic, Igor; Osipov, Evgeny; Portella, Maria J.; Redlich, Ronny; Repple, Jonathan; Sacchet, Matthew D.; Sämann, Philipp G.; Simulionyte, Egle; Soares, Jair C.; Walter, Martin; Watanabe, Norio; Whalley, Heather C.; Yüksel, Dilara; Veltman, Dick J.; Thompson, Paul M.; Schmaal, Lianne & Van Someren, Eus J. W. (2020). Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group. Translational Psychiatry.  ISSN 2158-3188.  10(1) . doi: 10.1038/s41398-020-01109-5 Full text in Research Archive.
• Leu, Costin; Richardson, Tom G.; Kaufmann, Tobias; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Busch, Robyn M.; Smith, George Davey & Lal, Dennis (2020). Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population. PLOS ONE.  ISSN 1932-6203.  15(4) . doi: 10.1371/journal.pone.0232292 Full text in Research Archive.
• Lind, Mackenzie; Brick, Leslie A; Gehrman, Philip R; Gelaye, Bizu; Maihofer, Adam X.; Nievergelt, Caroline M.; Nugent, Nicole R; Stein, Murray B; Amstadter,, Ananda B; Psychiatric Genomics Consorti, Posttraumatic Stress Disorder; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Søren B.; Andreassen, Ole Andreas; Arbisi, Paul A.; Ashley-Koch, Allison E.; Atkinson, Elizabeth G.; Austin, S. Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Børglum, Anders D.; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Chen, Chia-Yen; Coleman, Jonathan R. I.; Dale, Anders M.; Dalvie, Shareefa; Daly, Mark J.; Daskalakis, Nikolaos P.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Duncan, Laramie E.; Dzubur-Kulenovic, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D. & Forbes, David (2020). Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes. Sleep.  ISSN 0161-8105. . doi: 10.1093/sleep/zsz257
• Lund, Martina Jonette; Alnæs, Dag; Schwab, Simon; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping.  ISSN 1065-9471.  41(15), s 4173- 4186 . doi: 10.1002/hbm.25116 Full text in Research Archive.
• Lyngstad, Siv Hege; Bettella, Francesco; Aminoff, Sofie Ragnhild; Athanasiu, Lavinia; Andreassen, Ole Andreas; Færden, Ann & Melle, Ingrid (2020). Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  141(5), s 452- 464 . doi: 10.1111/acps.13167 Full text in Research Archive.
• Mäki-Marttunen, Verónica; Andreassen, Ole Andreas & Espeseth, Thomas (2020). The role of norepinephrine in the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews.  ISSN 0149-7634.  118, s 298- 314 . doi: 10.1016/j.neubiorev.2020.07.038 Full text in Research Archive.
• Manchia, Mirko; Vieta, Eduard; Smeland, Olav Bjerkehagen; Altimus, Cara; Bechdolf, Andreas; Bellivier, Frank; Bergink, Veerle; Fagiolini, Andrea; Geddes, John R.; Hajek, Tomas; Henry, Chantal; Kupka, Ralph; Lagerberg, Trine Vik; Licht, Rasmus W.; Martinez-Cengotitabengoa, Monica; Morken, Gunnar; Nielsen, René E.; Pinto, Ana Gonzalez; Reif, Andreas; Rietschel, Marcella; Ritter, Philipp; Schulze, Thomas G.; Scott, Janine Linda; Severus, Emanuel; Yildiz, Aysegul; Kessing, Lars Vedel; Bauer, Michael; Goodwin, Guy M. & Andreassen, Ole Andreas (2020). Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action. European Neuropsychopharmacology.  ISSN 0924-977X.  36, s 121- 136 . doi: 10.1016/j.euroneuro.2020.05.006 Full text in Research Archive.
• Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas & Svalheim, Sigrid (2020). Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure.  ISSN 1059-1311.  80, s 221- 225 . doi: 10.1016/j.seizure.2020.05.018 Full text in Research Archive.
• Mufford, Mary S; van der Meer, Dennis; Andreassen, Ole Andreas; Ramesar, Raj; Stein, Dan J. & Dalvie, Shareefa (2020). A review of systems biology research of anxiety disorders. Revista Brasileira de Psiquiatria.  ISSN 1516-4446. . doi: 10.1590/1516-4446-2020-1090 Full text in Research Archive.
• Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi-Ling; Coleman, Jonathan R.I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hübel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole Andreas; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramis, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Mayora, Monica Gratacos; Guillaume, Sebastien; Guo, Yiran; Hákonarson, Hákon H.; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Klump, Kelly L.; Knudsen, Gun Peggy Strømstad; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Mattingsdal, Morten & Reichborn-Kjennerud, Ted (2020). Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies. Addiction Biology.  ISSN 1355-6215. . doi: 10.1111/adb.12880
• Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2020). Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study. Human Brain Mapping.  ISSN 1065-9471.  41(16), s 4676- 4690 . doi: 10.1002/hbm.25149 Full text in Research Archive.
• Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Kaufmann, Tobias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry.  ISSN 2158-3188.  10(251) . doi: 10.1038/s41398-020-00931-1 Full text in Research Archive.
• Patel, Yash; Parker, Nadine; Shin, Jean; Howard, Derek; French, Leon; Thomopoulos, Sophia I.; Pozzi, Elena; Abe, Yoshinari; Abé, Christoph; Anticevic, Alan; Alda, Martin; Aleman, Andre; Alloza, Clara; Alonso-Lana, Silvia; Ameis, Stephanie H.; Anagnostou, Evdokia; McIntosh, Andrew; Arango, Celso; Arnold, Paul D; Asherson, Philip; Assogna, Francesca; Auzias, Guillaume; Ayesa-Arriola, Rosa; Bakker, Geor; Banaj, Nerisa; Banaschewski, Tobias; Bandeira, Cibele E; Baranov, Alexandr; Bargalló, Núria; Bau, Claiton H.D.; Baumeister, Sarah; Baune, Bernhard T.; Bellgrove, Mark A.; Benedetti, Francesco; Bertolino, Alessandro; Boedhoe, Premika S.W.; Boks, Marco; Bollettini, Irene; Bonnin, Caterina del Mar; Borgers, Tiana; Borgwardt, Stefan; Brandeis, Daniel; Brennan, Brian P.; Bruggemann, Jason M.; Bülow, Robin; Busatto, Geraldo F.; Calderoni, Sara; Calhoun, Vince D; Calvo, Rosa; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Carr, Vaughan J.; Cascella, Nicola; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Crespo-Facorro, Benedicto; Cubillo, Ana I.; Cullen, Kathryn R; Cupertino, Renata B; Daly, Eileen; Dannlowski, Udo; Davey, Christopher; Denys, Damiaan; Deruelle, Christine; Di Giorgio, Annabella; Dickie, Erin W.; Dima, Danai; Dohm, Katharina; Ehrlich, Stefan; Ely, Benjamin A.; Erwin-Grabner, Tracy; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Fatjó-Vilas, Mar; Fedor, Jennifer; Fitzgerald, Kate D.; Ford, Judith M.; Frodl, Thomas; Fu, Cynthia HY; Fullerton, Janice M.; Gabel, Matt C.; Glahn, David C; Roberts, Gloria; Gogberashvili, Tinatin; Goikolea, Jose M.; Gotlib, Ian H.; Goya-Maldonado, Roberto; Grabe, Hans J; Green, Melissa J.; Grevet, Eugenio H.; Groenewold, Nynke A.; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Guerrero-Pedraza, Amalia; Gur, Raquel E; Gur, Ruben C; Haar, Shlomi; Haarman, Bartholomeus C.M.; Haavik, Jan; Hahn, Tim; Hajek, Tomas; Harrison, Benjamin; Harrison, Neil A.; Hartman, Catharina A; Whalley, Heather C; Heslenfeld, Dirk J; Hibar, Derrek P; Hilland, Eva; Hirano, Yoshiyuki; Ho, Tiffany C.; Pieter J, Hoekstra; Liesbeth, Hoekstra; Sarah, Hohnmann; Hong, L. E.; Höschl, Cyril; Høvik, Marie Farstad; Howells, Fleur M.; Nenadic, Igor; Jalbrzikowski, Maria; James, Anthony C.; Janssen, Joost; Jaspers-Fayer, Fern; Xu, Jian; Jonassen, Rune; Karkashadze, Georgii; King, Joseph A.; Kircher, Tilo; Kirschner, Mathias; Koch, Kathrin; Kochunov, Peter; Kohls, Gregor; Konrad, Kerstin; Krämer, Bernd; Krug, Axel; Kuntsi, Jonna; Kwon, Jun Soo; Landén, Mikael; Landrø, Nils Inge; Lazaro, Luisa; Lebedeva, Irina; Leehr, Elisabeth J.; Lera-Miguel, Sara; Lesch, Klaus-Peter; Lochner, Christine; Louza, Mario R.; Luna, Beatriz; Lundervold, Astri J.; MacMaster, Frank P; Maglanoc, Luigi Angelo; Malpas, Charles B.; Portella, Maria J; Marsh, Rachel; Martyn, Fiona M.; Mataix-Cols, David; Mathalon, Daniel H.; McCarthy, Hazel; McDonald, Colm; McPhilemey, Genevieve; Susanne, Meinert; Menchon, José M.; Minuzzi, Luciano; Mitchell, Philip B.; Moreno, Carmen; Morgado, Pedro; Muratori, Filippo; Murphy, Clodagh; Murphy, Declan; Mwangi, Benson; Nabulsi, Leila; Nakagawa, Akiko; Nakamae, Takashi; Namazova, Leyla; Narayanaswamy, Janardhanan C.; Jahanshad, Neda; Nguyen, Danai D.; Nicolau, Rosa; O´Gorman Tuura, Ruth L.; O´Hearn, Kirsten; Oosterlaan, Jaap; Opel, Nils; Ophoff, Roel A.; Oranje, Bob; Ortiz García de la Foz, Victor; Overs, Bronwyn J.; Paloyelis, Yannis; Pantelis, Christos; Parellada, Mara; Pauli, Paul; Picó-Pérez, Maria; Picon, Felipe A.; Piras, Fabrizio; Piras, Federica; Plessen, Kerstin J.; Pomarol-Clotet, Edith; Preda, Adrian; Puig, Olga; Quide, Yann; Radua, Joaquim; Ramos-Quiroga, Josep-Antoni; Rasser, Paul E.; Rauer, Lisa; Reddy, Janardhan; Redlich, Ronny; Reif, Andreas; Reneman, Liesbeth; Repple, Jonathan; Retico, Alessandra; Richarte, Vanesa; Richter, Anja; Rosa, Pedro G. P:; Rubia, Katya; Hashimoto, Ryota; Sacchet, Matthew D.; Salvador, Raymond; Santonja, Javier; Sarink, Kelvin; Sarró, Salvador; Satterthwaite, Theodore D; Sawa, Akira; Schall, Ulrich; Schofield, Peter R; Schrantee, Anouk; Seitz, Jochen; Serpa, Mauricio H; Setién-Suero, Esther; Shaw, Philip; Shook, Devon; Silk, Tim J.; Sim, Kang; Simon, Schmitt; Blair Simpson, Helen; Singh, Aditya; Skoch, Antonin; Skokauskas, Norbert; Soares, Jair C; Soreni, Noam; Soriano-Mas, Carles; Spalletta, Gianfranco; Spaniel, Filip; Lawrie, Stephen M; Stern, Emily R.; Stewart, S Evelyn; Takayanagi, Yoichiro; Temmingh, Henk S; Tolin, David F.; Tomecek, David; Tordesillas-Gutierrez, Diana; Tosetti, Michela; Uhlmann, Anne; van Amelsvoort, Therese; Van Der Wee, Nic J.A.; van der Werff, Steven J A; Van Haren, Neeltje E M; van Wingen, Guido A.; Vance, Alasdair; Vazquez-Bourgon, Javier; Vecchio, Daniela; Venkatasubramanian, Ganesan; Vieta, Eduard; Vilarroya, Oscar; Vives-Gilabert, Yolanda; Voineskos, Aristotle N.; Völzke, Henry; Polier, Georg von; Walton, Esther; Weickert, Thomas W.; Shannon Weickert, Cynthia; Weideman, Andrea S; Wittfeld, Katharina; Wolf, Daniel H.; Wu, Mon-Ju; Yang, T T; Yang, Kun; Yoncheva, Yuliya N.; Yun, Je-Yeon; Cheng, Yuqi; Zanetti, Marcus V; Ziegler, Georg C.; Franke, Barbara; Hoogman, Martine; Buitelaar, Jan K; van Rooij, Daan; Andreassen, Ole Andreas; Ching, Christopher R K; Veltman, Dick J; Schmaal, Lianne; Stein, Dan J; van den Heuvel, Odile A; Turner, Jessica A; Van Erp, Theo G M; Pausova, Zdenka; Thomson, Paul & Paus, Tomáš (2020). Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA psychiatry.  ISSN 2168-6238.  78(1), s 47- 63 . doi: 10.1001/jamapsychiatry.2020.2694
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00672 Full text in Research Archive. Show summary

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies. Keywords: CVD risk; bipolar disorder; dyslipidemia; inflammatory biomarkers; schizophrenia.

• Rokicki, Jaroslav; Wolfers, Thomas; Nordhøy, Wibeke; Tesli, Natalia; Quintana, Daniel; Alnæs, Dag; Richard, Geneviève; de Lange, Ann-Marie Glasø; Lund, Martina Jonette; Norbom, Linn Christin Bonaventure; Agartz, Ingrid; Melle, Ingrid; Nærland, Terje; Selbæk, Geir; Persson, Karin Ester Torun; Nordvik, Jan Egil; Schwarz, Emanuel; Andreassen, Ole Andreas; Kaufmann, Tobias & Westlye, Lars Tjelta (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping.  ISSN 1065-9471.  s 1- 13 . doi: 10.1002/hbm.25323 Full text in Research Archive.
• Schwarz, Emanuel; Alnæs, Dag; Andreassen, Ole Andreas; Cao, Han; Chen, Junfang; Degenhardt, Franziska; Doncevic, Daria; Dwyer, Dominic; Eils, Roland; Erdmann, Jeanette; Herrmann, Carl; Hofmann-Apitius, Martin; Kaufmann, Tobias; Koutsouleris, Nikolaos; Kodamullil, Alpha T.; Khuntia, A.; Mucha, Sören; Nöthen, Markus M.; Paul, Riya; Pedersen, Mads Lund; Quintero, Andres; Schunkert, Heribert; Sharma, Ashwini; Tost, Heike; Westlye, Lars Tjelta; Zhang, Youcheng & Meyer-Lindenberg, Andreas (2020). Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-020-00915-z Full text in Research Archive.
• Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O`Connell, Kevin; Gani, Osman; Bahrami, Shahram; Uggen, Tea Kristiane Espeland; Djurovic, Srdjan; Holland, Dominic; Andreassen, Ole Andreas & Dale, Anders (2020). Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR. Bioinformatics.  ISSN 1367-4803. . doi: 10.1093/bioinformatics/btaa568 Full text in Research Archive.
• Shadrin, Alexey A.; Mucha, Sören; Ellinghaus, David; Makarious, Mary B; Blauwendraat, Cornelis; Sreelatha, Ashwin; Heras-Garvin, Antonio; Ding, Jinhui; Hammer, Monia B.; Foubert-Samier, Alexandra; Meissner, Wassilios G.; Rascol, Olivier; Traon, Anne Pavy-Le; Frei, Oleksandr; O`Connell, Kevin; Bahrami, Shahram; Schreiber, Stefan; Lieb, Wolfgang; Müller-Nurasyid, Martina; Schminke, Ulf; Homuth, Georg; Schmidt, Carsten O.; Nöthen, Markus M.; Hoffman, Per; Gieger, Christian; Wenning, Gregor; Gibbs, J. Raphael; Franke, Andre; Hardy, John; Stefanova, Nadia; Gasser, Thomas; Singleton, Andrew; Houlden, Henry; Scholz, Sonja W.; Andreassen, Ole Andreas & Sharma, Manu (2020). Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease. Movement Disorders.  ISSN 0885-3185. . doi: 10.1002/mds.28338 Full text in Research Archive.
• Sjølie, Charlotte; Meyn, Emilie K.; Raudeberg, Rune; Andreassen, Ole Andreas & Vaskinn, Anja (2020). Nonsocial cognitive underpinnings of theory of mind in schizophrenia. Psychiatry Research.  ISSN 0165-1781.  289 . doi: 10.1016/j.psychres.2020.113055 Full text in Research Archive. Show summary

  Social cognition is a mediator between nonsocial cognition and functional outcome in schizophrenia. However, the relationship between specific nonsocial cognitive and social cognitive domains is less clear. The aim of this study was to investigate which specific nonsocial cognitive domains best predict theory of mind (ToM) performance in schizophrenia. We indexed ToM by a composite score of the video-based Movie for the Assessment of Social Cognition test (MASCtot) in a sample of 91 individuals with schizophrenia. Nonsocial cognition was measured with the nonsocial cognitive subtests of the MATRICS Consensus Cognitive Battery (MCCB) and the Wechsler Abbreviated Scale of Intelligence (WASI IQ). Bivariate and multiple regression analyses were applied. We found statistically significant bivariate associations between MASCtot and five nonsocial cognitive tests, measuring intelligence, speed of processing, verbal or visual memory, and non-verbal working memory. Together, they accounted for 17% of the variation in MASCtot, but none of the five tests made significant unique contributions to MASCtot in the regression analysis. Our results confirm that nonsocial cognition and ToM are associated, albeit distinct, constructs. The findings suggest that cognitive remediation must include social cognitive targets in order to achieve improved ToM and better functioning.

• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Dale, Anders & Andreassen, Ole Andreas (2020). The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nature Reviews Neurology.  ISSN 1759-4758.  s 1- 14 . doi: 10.1038/s41582-020-0364-0
• Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen; Frei, Oleksandr; Wirgenes, Katrine Verena; O`Connell, Kevin; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Sugrue, Leo P.; Wang, Yunpeng; Svenningsson, Per; Sharma, Manu; Pihlstrøm, Lasse; Toft, H. Mathias S.; O’Donovan, Michael; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M. & Andreassen, Ole Andreas (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry.  ISSN 0006-3223.  89(3), s 227- 235 . doi: 10.1016/j.biopsych.2020.01.026 Full text in Research Archive. Show summary

  BACKGROUND:Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involvedysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between thedisorders, and movement disturbances are common in patients with SCZ before treatment with antipsychotic drugs.Despite this, little is known about shared genetic etiology between the disorders.METHODS:We analyzed recent large genome-wide association studies on patients with SCZ (N= 77,096) and PD(N= 417,508) using a conditional/conjunctional false discovery rate (FDR) approach to evaluate overlap incommon genetic variants and improve statistical power for genetic discovery. Using a variety of biologicalresources, we functionally characterized the identified genomic loci.RESULTS:We observed genetic enrichment in PD conditional onassociations with SCZ and vice versa, indicatingpolygenic overlap. We then leveraged this cross-trait enrichment using conditional FDR analysis and identified 9 novel PDrisk loci and 1 novel SCZ locus at conditional FDR,.01. Furthermore, we identified 9 genomic loci jointly associated withPD and SCZ at conjunctional FDR,.05. There was an even distribution of antagonistic and agonistic effect directionsamong the shared loci, in line with the insignificant genetic correlation between the disorders. Of 67 genes mapped to theshared loci, 65 are expressed in the human brain and show cell type–specific expression profiles.CONCLUSIONS:Altogether, the study increases understanding of the genetic architectures underlying SCZ and PD,indicating that common molecular genetic mechanisms may contribute to overlapping pathophysiological and clinicalfeatures between the disorders.

• Smelror, Runar; Rund, Bjørn Rishovd; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Wedervang-Resell, Kirsten; Andreassen, Ole Andreas; Ueland, Torill; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Negative and disorganized symptoms mediate the relationship between verbal learning and global functioning in adolescents with early-onset psychosis. European Child and Adolescent Psychiatry.  ISSN 1018-8827. . doi: 10.1007/s00787-020-01479-7 Full text in Research Archive.
• Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas & Molden, Espen (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry.  ISSN 2158-3188.  10(1), s 1- 10 . doi: 10.1038/s41398-020-00888-1 Full text in Research Archive.
• Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus; Andreassen, Ole Andreas & Molden, Espen (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research.  ISSN 0920-9964.  228, s 590- 596 . doi: 10.1016/j.schres.2020.11.025 Show summary

  Background: Nonadherence to antipsychotics may cause relapse and hospitalizations in patients with psychotic disorders. The purpose was to quantify and compare the outpatient's nonadherence rates of atypical antipsychotics by objective detection in blood samples. Methods: Totally, 13,217 outpatients with therapeutic drug monitoring (TDM) data of atypical antipsychotics were included. An event of complete nonadherence was defined as an occurrence of undetectable level of a prescribed antipsychotic in the blood sample submitted for TDM. Patients with such an event(s) were defined as nonadherent of the respective drug treatment (outcome). The rates of nonadherence patients were compared between the drugs by logistic regression. Results: In the study population, 70.2% of the patients were prescribed doses compliant with a schizophrenia diagnosis. The mean olanzapine equivalent dose in the population was 13.4 mg (95% confidence interval (CI): 13.3, 13.6). The frequency of nonadherence patients, regardless of drug, was 3.7% (CI: 3.4-4.0). The nonadherence patient rate was lowest in clozapine-treated patients (2.2%; CI: 1.5-2.8), followed by aripiprazole (2.3%; 1.7-2.8), risperidone (2.4%; 1.6-3.0), quetiapine (2.8%; 2.3-3.2) and olanzapine (4.9%; 4.1-5.3). Users of olanzapine had significantly higher risk of complete nonadherence (Odds ratio: 1.9; CI: 1.6-2.3, p < 0.001) compared to patients treated with other antipsychotics as a group. Conclusions: In this study, complete nonadherence of atypical antipsychotics, measured as undetectable blood level, was disclosed for ~5% of outpatients with psychotic disorders. The rate of complete nonadherence was significantly higher during olanzapine treatment compared to other atypical antipsychotics. Further studies should investigate if this reflects drug differences in tolerability or other causal relationships. Keywords: Atypical antipsychotics; Nonadherence; Olanzapine; Outpatient treatment; Therapeutic drug monitoring.

• Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus; Andreassen, Ole A & Molden, Espen (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology.  ISSN 0924-977X.  37, s 64- 69 . doi: 10.1016/j.euroneuro.2020.06.007
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato; Friestad, Christine; Andreassen, Ole Andreas; Melle, Ingrid & Haukvik, Unn Kristin H. (2020). Childhood trauma in persons with schizophrenia and a history of interpersonal violence. Frontiers in Psychiatry.  ISSN 1664-0640.  11 . doi: 10.3389/fpsyt.2020.00383 Full text in Research Archive.
• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid; Bjella, Thomas; Aukrust, Pål; Le Hellard, Stephanie; Stavrum, Anne-Kristin; Melle, Ingrid; Andreassen, Ole Andreas & Djurovic, Srdjan (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry.  ISSN 1664-0640.  11, s 1- 10 . doi: 10.3389/fpsyt.2020.00642 Full text in Research Archive.
• Sæther, Linn Sofie; Roelfs, Daniël Thomas Heimen; Moberget, Torgeir; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar & Vaskinn, Anja (2020). Exploring neurophysiological markers of visual perspective taking: Methodological considerations. International Journal of Psychophysiology.  ISSN 0167-8760. . doi: 10.1016/j.ijpsycho.2020.12.006 Full text in Research Archive. Show summary

  Rationale: For visual perspective taking (VPT) using the avatar task, examinations of neural processes using event related potentials (ERP) indicate a distinction between an early posterior perspective calculation process (P3) and a later frontal process (LFSW) managing perspective conflict. While it is unknown if these neural processes are affected in clinical populations, it is unclear if the avatar task can be applied to this group, due to the long duration and sensitivity to data loss. Thus, we performed a methodological study of the avatar task, testing the feasibility of a shortened experimental paradigm. Objective: To investigate whether previously reported behavioural and ERP effects in the avatar task can also be seen if analysing all trials (matching/non-matching) jointly, and whether they remain robust if only a subset of the data is analysed. Method: Healthy individuals (n = 20) completed the avatar task with ERP measurement. ERP components (P3, LFSW) and behavioural data were investigated by A) comparing use of only matching trials (n = 384) versus all trials (n = 768), and B) examining if reduced duration of assessment, by analysing only a subset of the data, impacts ERP findings. Results: We observed minimal differences when analysing data from only matching trial types compared to all trial types. Further, ERP amplitudes and latency findings were replicated when analysing only a subset of the data. Conclusions: The duration of the avatar task can be reduced to avoid long testing times, thus making it better suited for use in clinical populations.

• Tao, Qi; Miao, Yun; Li, Huihui; Yuan, Xiuxia; Huang, Xufeng; Wang, Yunpeng; Andreassen, Ole Andreas; Fan, Xiaoduo; Yang, Yongfeng & Song, Xueqin (2020). Insulin Resistance and Oxidative Stress: In Relation to Cognitive Function and Psychopathology in Drug-Naïve, First-Episode Drug-Free Schizophrenia. Frontiers in Psychiatry.  ISSN 1664-0640. . doi: 10.3389/fpsyt.2020.537280 Full text in Research Archive.
• Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato; Jensen, Arvid; Hjell, Gabriela; Bell, Christina; Fischer-Vieler, Thomas; Tesli, Martin Steen; Andreassen, Ole Andreas; Melle, Ingrid; Agartz, Ingrid & Haukvik, Unn Kristin H. (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-020-01098-y Full text in Research Archive.
• Thompson, Paul M.; Jahanshad, Neda; Ching, Christopher R.K.; Salminen, Lauren E.; Thomopoulos, Sophia I.; Bright, Joanna; Baune, Bernhard T.; Bertolin, Sara; Bralten, Janita; Bruin, Willem B.; Bulow, Robin; Chen, Jian; Chye, Yann; Dannlowski, Udo; de Kovel, Carolien G.F.; Donohoe, Gary; Eyler, Lisa T.; Faraone, Stephen V.; Favre, Pauline; Filippi, Courtney A.; Frodl, Thomas; Garijo, Daniel; Gil, Yolanda; Grabe, Hans J.; Grasby, Katrina L.; Hajek, Tomas; Han, Laura K.M.; Hatton, Sean N.; Hilbert, Kevin; Ho, Tiffany C.; Holleran, Laurena; Homuth, Georg; Hosten, Norbert; Houenou, Josselin; Ivanov, Iliyan; Jia, Tianye; Kelly, Sinead; Klein, Marieke; Kwon, Jun Soo; Laansma, Max A.; Leerssen, Jeanne; Lueken, Ulrike; Nunes, Abraham; O'Neill, Joseph; Opel, Nils; Piras, Fabrizio; Piras, Federica; Postema, Merel C.; Pozzi, Elena; Shatokhina, Natalia; Soriano-Mas, Carles; Spalletta, Gianfranco; Sun, Daqiang; Teumer, Alexander; Tilot, Amanda K.; Tozzi, Leonardo; van der Merwe, Celia; van Someren, Eus J.W.; van Wingen, Guido A.; Völzke, Henry; Walton, Esther; Wang, Lei; Winkler, Anderson M.; Wittfeld, Katharina; Wright, Margaret J.; Yun, Je-Yeon; Zhang, Guohao; Zhang-James, Yanli; Adhikari, Bhim M.; Agartz, Ingrid; Aghajani, Moji; Aleman, André; Althoff, Robert R.; Altmann, Andre; Andreassen, Ole Andreas; Baron, David A.; Bartnik-Olson, Brenda L.; Bas-Hoogendam, Janna Marie; Baskin-Sommers, Arielle R.; Bearden, Carrie E.; Berner, Laura A.; Boedhoe, Premika S.W.; Brouwer, Rachel M.; Buitelaar, Jan K.; Caeyenberghs, Karen; Cecil, Charlotte A.M.; Cohen, Ronald A.; Cole, James H.; Conrod, Patricia J.; De Brito, Stephane A.; de Zwarte, Sonja M.C.; Dennis, Emily L.; Desrivieres, Sylvane; Dima, Danai; Ehrlich, Stefan; Esopenko, Carrie; Fairchild, Graeme; Fisher, Simon E.; Fouche, Jean-Paul; Francks, Clyde; Frangou, Sophia; Franke, Barbara; Garavan, Hugh P.; Glahn, David C.; Groenewold, Nynke A.; Gurholt, Tiril Pedersen; Gutman, Boris A.; Hahn, Tim; Harding, Ian H.; Hernaus, Dennis; Hibar, Derrek P.; Hillary, Frank G.; Hoogman, Martine; Hulshoff Pol, Hilleke E.; Jalbrzikowski, Maria; Karkashadze, George A.; Klapwijk, Eduard T.; Knickmeyer, Rebecca C.; Kochunov, Peter; Koerte, Inga K.; Kong, Xiang-Zhen; Liew, Sook-Lei; Lin, Alexander P.; Logue, Mark W.; Luders, Eileen; Macciardi, Fabio; Mackey, Scott; Mayer, Andrew R.; McDonald, Carrie R.; McMahon, Agnes B.; Medland, Sarah E.; Modinos, Gemma; Morey, Rajendra A.; Mueller, Sven C.; Mukherjee, Pratik; Namazova-Baranova, Leyla; Nir, Talia M; Olsen, Alexander; Paschou, Peristera; Pine, Daniel S.; Pizzagalli, Fabrizio; Rentería, Miguel E.; Rohrer, Jonathan D.; Sämann, Philipp G.; Schmaal, Lianne; Schumann, Gunter; Shiroishi, Mark S.; Sisodiya, Sanjay M.; Smit, Dirk J.A.; Sønderby, Ida Elken; Stein, Dan J.; Stein, Jason L.; Tahmasian, Masoud; Tate, David F.; Turner, Jessica A.; van den Heuvel, Odile A; Van Der Wee, Nic J.A.; van der Werf, Ysbrand D.; van Erp, Theo G.M.; van Haren, Neeltje E.M.; van Rooij, Daan; van Velzen, Laura S.; Veer, Ilya M.; Veltman, Dick J.; Villalon-Reina, Julio E.; Walter, Henrik; Whelan, Christopher D.; Wilde, Elisabeth A.; Zarei, Mojtaba & Zelman, Vladimir (2020). ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry.  ISSN 2158-3188.  10:100, s 1- 28 . doi: 10.1038/s41398-020-0705-1 Full text in Research Archive.
• Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  5(12), s 1095- 1103 . doi: 10.1016/j.bpsc.2020.06.014 Full text in Research Archive.
• Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides; Beck, Dani; Richard, Geneviève; Sæther, Linn Sofie; Haatveit, Beathe Christin; Skaug, Knut-André; Nordvik, Jan Egil; Hatlestad-Hall, Christoffer; Einevoll, Gaute; Mäki-Marttunen, Tuomo; Westlye, Lars Tjelta; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Elvsåshagen, Torbjørn (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage.  ISSN 1053-8119. . doi: 10.1016/j.neuroimage.2020.117302 Full text in Research Archive.
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K.; O'Connell, Kevin S.; Monereo Sanchez, Jennifer; Linden, David E.J.; Westlye, Lars Tjelta; Dale, Anders M & Andreassen, Ole Andreas (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex.  ISSN 1047-3211.  30(10), s 5597- 5603 . doi: 10.1093/cercor/bhaa146 Full text in Research Archive.
• van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna; Smeland, Olav Bjerkehagen; Thompson, Wesley Kurt; Fan, Chun Chieh; Holland, Dominic; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Dale, Anders (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications.  ISSN 2041-1723.  11:3512, s 1- 9 . doi: 10.1038/s41467-020-17368-1
• Vaskinn, Anja; Haatveit, Beathe; Melle, Ingrid; Andreassen, Ole Andreas; Ueland, Torill & Sundet, Kjetil Søren (2020). Cognitive Heterogeneity Across Schizophrenia and Bipolar Disorder: A Cluster Analysis of Intellectual Trajectories. Journal of the International Neuropsychological Society.  ISSN 1355-6177. . doi: 10.1017/s1355617720000442
• Wang, Yunpeng; Nudel, Ron; Benros, Michael Eriksen; Skogstrand, Kristin; Fishilevich, Simon; Lancet, Doron; Sun, Jiangming; Hougaard, David M.; Andreassen, Ole Andreas; Mortensen, Preben Bo; Buil, Alfonso; Hansen, Thomas Folkmann; Thompson, Wesley K & Werge, Thomas (2020). Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth. PLoS Genetics.  ISSN 1553-7390. . doi: https://doi.org/10.1371/journal.pgen.1009163 Full text in Research Archive.
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund; Johannessen, Cecilie Haggag; Lekva, Tove; Lonning, Vera Louise Hiorth; Smelror, Runar; Szabo, Attila; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia.  ISSN 2334-265X.  6, s 1- 8 . doi: 10.1038/s41537-020-00112-5 Full text in Research Archive.
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research.  ISSN 0920-9964.  218, s 55- 62 . doi: 10.1016/j.schres.2020.03.006 Full text in Research Archive.
• Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N.; Albajes-Eizagirre, Anton; Alnæs, Dag; Alpert, Kathryn I.; Andreassen, Ole Andreas; Anticevic, Alan; Gurholt, Tiril Pedersen; De Haan, Lieuwe; Haatveit, Beathe Christin; Jönsson, Erik Gunnar; Joska, John; Kalnin, Andrew J.; Klein, Marieke; Koenders, Laura; Kolskår, Knut-Kristian; van der Meer, Dennis; Menchon, José M.; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J.; Radua, Joaquim; Reif, Andreas; Richard, Geneviéve´; Weber, Bernd; Wen, Wei; West, John D.; Westlye, Lars Tjelta; Whalley, Heather C.; Williams, Steven Charles Rees; Wittfeld, Katharina; Wolf, Daniel H.; Wright, Margaret J.; Yoncheva, Yuliya N.; Zanetti, Marcus V.; Ziegler, Georg C.; de Zubicaray, Greig I.; Thompson, Paul M.; Crone, Eveline A.; Frangou, Sophia & Tamnes, Christian Krog (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping.  ISSN 1065-9471. . doi: 10.1002/hbm.25204 Full text in Research Archive.
• Winterton, Adriano; Rødevand, Linn; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews.  ISSN 2046-4053.  9(1) . doi: 10.1186/s13643-020-01369-8 Full text in Research Archive.
• Winterton, Adriano; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Improving the precision of intranasal oxytocin research. Nature Human Behaviour.  ISSN 2397-3374.  s 1- 10 . doi: 10.1038/s41562-020-00996-4
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell.  ISSN 0092-8674.  179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020 Full text in Research Archive.
• Aas, Monica; Bellivier, Frank; Bettella, Francesco; Henry, Chantal; Gard, Sebastien; Kahn, Jean-Pierre; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Melle, Ingrid; Leboyer, Marion; Jamain, Stéphane; Andreassen, Ole Andreas & Étain, Bruno (2019). Childhood maltreatment and polygenic risk in bipolar disorders. Bipolar Disorders.  ISSN 1398-5647.  s 1- 8 . doi: 10.1111/bdi.12851
• Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry.  ISSN 2158-3188.  9 . doi: 10.1038/s41398-019-0432-7 Full text in Research Archive.
• Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill; Melle, Ingrid; Agartz, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2019.01.011 Full text in Research Archive.
• Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan & Hughes, Timothy (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology.  ISSN 0893-133X.  s 1- 9 . doi: 10.1038/s41386-019-0556-8 Full text in Research Archive.
• Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M.; Bertolino, Alessandro; Brandt, Christine Lycke; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik Gunnar; Kirsch, Peter; Lund, Martina Jonette; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry.  ISSN 2168-6238.  76(7), s 739- 748 . doi: 10.1001/jamapsychiatry.2019.0257
• Anderssen, Jannicke Fjæra; Simonsen, Carmen Elisabeth; Büchmann, Camilla Bakkalia; Barrett, Elizabeth Ann; Bjella, Thomas; Lagerberg, Trine Vik; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Melle, Ingrid & Aas, Monica (2019). Sleep disturbances in schizophrenia spectrum and bipolar disorders ? a transdiagnostic perspective. Comprehensive Psychiatry.  ISSN 0010-440X.  91, s 6- 12 . doi: 10.1016/j.comppsych.2019.02.006 Full text in Research Archive.
• Bakke, Laura A. Wortinger; Engen, Kristine; Barth, Claudia; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Andreassen, Ole Andreas; Haukvik, Unn Kristin H.; Vaskinn, Anja; Ueland, Torill & Agartz, Ingrid (2019). Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants. Psychological Medicine.  ISSN 0033-2917.  s 1- 9 . doi: 10.1017/S0033291719002046
• Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias; Ardau, Raffaella; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Becerra-Palars, Claudia; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa-Oketcho, Harriet; Bjella, Thomas; Cabrera, Jorge; Wo Cheung, Eric Y.; Del Zompo, Maria; Dodd, Seetal; Donix, Markus; Etain, Bruno; Fagiolini, Andrea; Fountoulakis, Kostas N.; Frye, Mark A.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Harima, Hirohiko; Henry, Chantal; Isometsä, Erkki T.; Janno, Sven; Kapczinski, Flávio; Kardell, Mathias; Khaldi, Slim; Kliwicki, Sebastian; Konig, Barbara; Kot, Timur L.; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Landén, Mikael; Larsen, Erik R.; Lewitzka, Ute; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Meza-Urzua, Fatima; Ming, Mok Yee; Monteith, Scott; Morken, Gunnar; Mosca, Enrica; Mozzhegorov, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nery, Fabiano G.; Nielsen, René E.; O'Donovan, Claire; Omrani, Adel; Osher, Yamima; Sørensen, Helle Østermark; Ouali, Uta; Ruiz, Yolanda Pica; Pilhatsch, Maximilian; Pinna, Marco; da Ponte, Francisco D.R.; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reddy, Mrinalini S.; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Raghuraman, Bharathram Sathur; Scippa, Ângela M.; Severus, Emanuel; Simhandl, Christian; Stackhouse, Paul W.; Stein, Dan J.; Strejilevich, Sergio; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Tondo, Leonardo; Torrent, Carla; Vaaler, Arne; Vares, Edgar; Veeh, Julia; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Zetin, Mark; Zgueb, Yosra & Whybrow, Peter C. (2019). Association between solar insolation and a history of suicide attempts in bipolar I disorder. Journal of Psychiatric Research.  ISSN 0022-3956.  113, s 1- 9 . doi: 10.1016/j.jpsychires.2019.03.001
• Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive & Selbæk, Geir (2019). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease. Translational Psychiatry.  ISSN 2158-3188.  9:273, s 1- 10 . doi: 10.1038/s41398-019-0592-5 Full text in Research Archive. Show summary

  Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.

• de Lange, Ann-Marie Glasø; Kaufmann, Tobias; van der Meer, Dennis; Maglanoc, Luigi Angelo; Alnæs, Dag; Moberget, Torgeir; Douaud, Gwenaëlle; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Population-based neuroimaging reveals traces of childbirth in the maternal brain. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  116(44), s 22341- 22346 . doi: 10.1073/pnas.1910666116
• de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, André; Alpert, Kathryn I.; Bearden, Carrie E.; Bertolino, Alessandro; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E.L.; Cahn, Wiepke; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; de la Serna, Elena; di Giorgio, Annabella; Doucet, Gaëlle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Frankland, Andrew; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hillegers, Manon H.J.; Hulshoff Pol, Hilleke E.; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik Gunnar; Kane, Fergus; Kempton, Matthew J.; Koenis, Marinka M.G.; Kopecek, Miloslav; Krabbendam, Lydia; Krämer, Bernd; Lawrie, Stephen M.; Lenroot, Rhoshel K.; Marcelis, Machteld; Marsman, Jan-Bernard C.; Mattay, Venkata S.; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B.; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Özerdem, Ayşegül; Picchioni, Marco M.; Richter, Anja; Roberts, Gloria; Aydogan, Aybala Saricicek; Schofield, Peter R.; Simsek, Fatma; Soares, Jair C.; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Daniel R.; Whalley, Heather C.; Yalin, Nefize; Andreassen, Ole Andreas; Ching, Christopher R.K.; van Erp, Theo G.M.; Turner, Jessica A.; Jahanshad, Neda; Thompson, Paul M.; Kahn, René S. & van Haren, Neeltje E.M. (2019). The association between familial risk and brain abnormalities is disease specific: An ENIGMA-relatives study of schizophrenia and bipolar disorder. Biological Psychiatry.  ISSN 0006-3223.  86(7), s 545- 556 . doi: 10.1016/j.biopsych.2019.03.985 Full text in Research Archive.
• Di Sero, Alessia; Jørgensen, Kjetil Nordbø; Nerland, Stener; Melle, Ingrid; Andreassen, Ole Andreas; Jovicich, Jorge & Agartz, Ingrid (2019). Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status. Schizophrenia Research.  ISSN 0920-9964.  208, s 114- 123 . doi: 10.1016/j.schres.2019.04.002
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548.  13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary

  Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.

• Elman, Jeremy A.; Panizzon, Matthew S; Logue, Mark W.; Gillespie, Nathan A.; Neale, Michael C.; Reynolds, Chandra A.; Gustavson, Daniel E.; Rana, Brinda K; Andreassen, Ole Andreas; Dale, Anders M; Franz, Carol E; Lyons, Michael J & Kremen, William S (2019). Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiology of Aging.  ISSN 0197-4580. . doi: 10.1016/j.neurobiolaging.2019.06.001
• Engh, John; Egeland, Jens; Andreassen, Ole Andreas; Bang-Kittilsen, Gry; Bigseth, Therese Torgersen; Holmen, Tom Langerud; Martinsen, Egil Wilhelm; Mordal, Jon & Andersen, Eivind (2019). Objectively Assessed Daily Steps—Not Light Intensity Physical Activity, Moderate-to-Vigorous Physical Activity and Sedentary Time—Is Associated With Cardiorespiratory Fitness in Patients With Schizophrenia. Frontiers in Psychiatry.  ISSN 1664-0640.  10 . doi: 10.3389/fpsyt.2019.00082 Full text in Research Archive.
• Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel; Abé, Christoph; Alda, Martin; Alloza, Clara; Alonso-Lana, Silvia; Andreassen, Ole Andreas; Baune, Bernhard T.; Benedetti, Francesco; Busatto, Geraldo F.; Canales-Rodríguez, Erick J.; Caseras, Xavier; Chaim-Avancini, Tiffany Moukbel; Ching, Christopher R.K.; Dannlowski, Udo; Deppe, Michael; Eyler, Lisa T.; Fatjo-Vilas, Mar; Foley, Sonya F.; Grotegerd, Dominik; Hajek, Tomas; Haukvik, Unn Kristin H.; Howells, Fleur M; Jahanshad, Neda; Kugel, Harald; Lagerberg, Trine Vik; Lawrie, Stephen M.; Linke, Julia O.; McIntosh, Andrew; Melloni, Elisa M.T.; Mitchell, Philip B.; Polosan, Mircea; Pomarol-Clotet, Edith; Repple, Jonathan; Roberts, Gloria; Roos, Annerine; Rosa, Pedro G.P.; Salvador, Raymond; Sarró, Salvador; Schofield, Peter R.; Serpa, Mauricio H; Sim, Kang; Stein, Dan J.; Sussmann, Jess E.; Temmingh, Henk S.; Thompson, Paul M.; Verdolini, Norma; Vieta, Eduard; Wessa, Michele; Whalley, Heather C.; Zanetti, Marcus V.; Leboyer, Marion; Mangin, Jean-François; Henry, Chantal; Duchesnay, Edouard & Houenou, Josselin (2019). Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology.  ISSN 0893-133X.  44, s 2285- 2293 . doi: 10.1038/s41386-019-0485-6
• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Mæland, Steffen; O`Connell, Kevin; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-10310-0 Full text in Research Archive.
• Frøyhaug, Mathias; Andersson, Stein; Andreassen, Ole Andreas; Ueland, Torill & Vaskinn, Anja (2019). Theory of mind in schizophrenia and bipolar disorder: psychometric properties of the Norwegian version of the Hinting Task. Cognitive Neuropsychiatry.  ISSN 1354-6805.  24(6), s 454- 469 . doi: 10.1080/13546805.2019.1674645 Full text in Research Archive.
• Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin & Melle, Ingrid (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  s 1- 10 . doi: 10.1007/s00406-019-01017-w Full text in Research Archive.
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139(5), s 464- 471 . doi: 10.1111/acps.13019 Full text in Research Archive.
• Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole Andreas; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire; Dellenvall, Karin; Demontis, Ditte; De Rubeis, Silvia; Devlin, Bernie; Djurovic, Srdjan; Dumont, Ashley L.; Goldstein, Jacqueline I.; Hansen, Christine S.; Hauberg, Mads Engel; Hollegaard, Mads V.; Hope, Sigrun; Howrigan, Daniel P.; Huang, Hailiang; Hultman, Christina M.; Klei, Lambertus; Maller, Julian; Martin, Joanna; Martin, Alicia R.; Moran, Jennifer L.; Nyegaard, Mette; Nærland, Terje; Palmer, Duncan S.; Palotie, Aarno; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; dPoterba, Timothy; Poulsen, Jesper Buchhave; St. Pourcain, Beate; Qvist, Per; Rehnström, Karola; Reichenberg, Abraham; Reichert, Jennifer; Robinson, Elise B.; Roeder, Kathryn; Roussos, Panos; Saemundsen, Evald; Sandin, Sven; Satterstrom, F. Kyle; Smith, George Davey; Stefánsson, Hreinn; Steinberg, Stacy; Stevens, Christine R.; Sullivan, Patrick F.; Turley, Patrick; Walters, G. Bragi; Xu, Xinyi; Stefansson, Kari; Geschwind, Daniel H.; Nordentoft, Merete; Hougaard, David M.; Werge, Thomas; Mors, Ole; Mortensen, Preben Bo; Neale, Benjamin M.; Daly, Mark J. & Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics.  ISSN 1061-4036.  51, s 431- 444 . doi: 10.1038/s41588-019-0344-8 Show summary

  Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping Genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared With other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD

• Gudmundsson, Ólafur Ó.; Walters, Gudmundur Bragi; Ingason, Andrés; Johansson, Stefan; Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Gustafsson, Omar; Nawaz, Muhammad Sulaman; Jónsson, Gudbjörn F.; Jónsson, Lina; Knappskog, Per; Ingvarsdóttir, Ester; Davidsdóttir, Katrin; Djurovic, Srdjan; Knudsen, Gun Peggy Strømstad; Askeland, Ragna Bugge; Haraldsdóttir, Gyda S.; Baldursson, Gísli; Magnússon, Páll; Sigurdsson, Engilbert; Gudbjartsson, Daníel Fannar; Stéfansson, Hreinn; Andreassen, Ole Andreas; Haavik, Jan; Reichborn-Kjennerud, Ted & Stefánsson, Kári (2019). Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational Psychiatry.  ISSN 2158-3188.  9, s 1- 9 . doi: 10.1038/s41398-019-0599-y Full text in Research Archive.
• Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Donohoe, Gary; Gill, M; Corvin, A & Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics.  ISSN 0148-7299. . doi: 10.1002/ajmg.b.32716
• Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan; Jönsson, Erik Gunnar; Melle, Ingrid; Holmans, P.; Faraone, Stephen V. & Glatt, Stephen J. (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-019-0463-8
• Holmen, Tom Langerud; Egeland, Jens; Andersen, Eivind; Mordal, Jon; Andreassen, Ole Andreas; Ueland, Thor; Bigseth, Therese Torgersen; Bang-Kittilsen, Gry & Engh, John (2019). The association between cardiorespiratory fitness and cognition appears neither related to current physical activity nor mediated by brain-derived neurotrophic factor in a sample of outpatients with schizophrenia. Frontiers in Psychiatry.  ISSN 1664-0640.  10:785, s 1- 7 . doi: 10.3389/fpsyt.2019.00785 Full text in Research Archive. Show summary

  Objective: We investigated whether levels of current physical activity (PA) contribute to the established relationship between cardiorespiratory fitness (CRF) and cognition in schizophrenia and whether brain-derived neurotrophic factor (BDNF) or its precursor proBDNF mediates this relationship. Method: Sixty-one outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale (WAIS) and nine subtests from the MATRICS battery comprising a neurocognitive composite score (NCS). CRF was assessed with peak oxygen uptake (VO2peak) measured directly during a maximum exercise test. Current PA levels were objectively assessed by an accelerometer worn for four consecutive days. BDNF and proBDNF were measured in fasting blood. Four serial parallel mediation analyses and two additional parallel mediation analyses were conducted, while controlling for age and sex at all levels. Results: No direct effects were found between PA measures and WAIS or NCS. No significant mediating effects of CRF or BDNF/proBDNF were detected. Conclusion: The results do not support the hypothesis that PA contributes to the naturally occurring relationship between CRF and cognition in schizophrenia or the hypothesis that BDNF or proBDNF mediates this relationship. The results arguably support the assumption that the association between CRF and cognition in schizophrenia is established developmentally early.

• Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr; Nordvik, Jan Egil; Kolskår, Knut-Kristian; Richard, Geneviève; Andreassen, Ole Andreas; Harbo, Hanne Flinstad & Westlye, Lars Tjelta (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology.  ISSN 1664-2295.  10:450, s 1- 9 . doi: 10.3389/fneur.2019.00450 Full text in Research Archive.
• Høyland, Anne Lise; Nærland, Terje; Engstrøm, Morten; Torske, Tonje; Lydersen, Stian & Andreassen, Ole Andreas (2019). Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study. Molecular Autism.  ISSN 2040-2392.  10(10) . doi: 10.1186/s13229-019-0259-3 Full text in Research Archive.
• Icick, Romain; Melle, Ingrid; Étain, Bruno; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Leboyer, Marion.; Aas, Monica; Henry, Chantal; Bjella, Thomas; Andreassen, Ole Andreas; Bellivier, Frank & Lagerberg, Trine Vik (2019). Tobacco smoking and other substance use disorders associated with recurrent suicide attempts in bipolar disorder.. Journal of Affective Disorders.  ISSN 0165-0327.  256, s 348- 357 . doi: 10.1016/j.jad.2019.05.075
• Ing, Alex J.; Sämann, Philipp G.; Chu, Congying; Tay, Nicole; Biondo, Francesca; Robert, Gabriel; Jia, Tianye; Wolfers, Thomas; Desrivières, Sylvane; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Conrod, Patricia; Fadai, Tahmine; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip A.; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Ittermann, Bernd; Kappel, Viola; Martinot, Jean-Luc; Meyer-Lindenberg, Andreas; Millenet, Sabina; Nees, Frauke; van Noort, Betteke; Orfanos, Dimitri Papadopoulos; Martinot, Marie-Laure Paillère; Penttilä, Jani; Poustka, Luise; Quinlan, Erin Burke; Smolka, Michael N.; Stringaris, Argyris; Struve, Maren; Veer, Ilya M.; Walter, Henrik; Whelan, Robert; Andreassen, Ole Andreas; Agartz, Ingrid; Lemaître, Hervé; Barker, Edward D.; Ashburner, John; Binder, Elisabeth; Buitelaar, Jan; Marquand, André; Robbins, Trevor W. & Schumann, Gunter (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour.  ISSN 2397-3374.  3(12), s 1306- 1318 . doi: 10.1038/s41562-019-0738-8
• Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton L.; Kim, Jonggeol J.; Liu, Ganqiang; Maple-Grødem, Jodi; Corvol, Jean-Christophe; Pihlstrøm, Lasse; van Nimwegen, Marlies; Hutten, Samantha J.; Nguyen, Khanh-Dung H.; Rick, Jacqueline; Eberly, Shirley; Faghri, Faraz; Auinger, Peggy; Scott, Kirsten M.; Wijeyekoon, Ruwani; Van Deerlin, Vivianna M.; Hernandez, Dena G.; Gibbs, J. Raphael; Chitrala, Kumaraswamy Naidu; Day-Williams, Aaron G.; Brice, Alexis; Alves, Guido Werner; Noyce, Alastair J.; Tysnes, Ole-Bjørn; Evans, Jonathan R.; Breen, David P.; Estrada, Karol; Wegel, Claire E.; Danjou, Fabrice; Simon, David K.; Andreassen, Ole Andreas; Ravina, Bernard; Toft, Mathias; Heutink, Peter; Bloem, Bastiaan R.; Weintraub, Daniel; Barker, Roger A.; Williams-Gray, Caroline H.; van de Warrenburg, Bart P.; van Hilten, Jacobus J.; Scherzer, Clemens R.; Singleton, Andrew B. & Nalls, Mike A. (2019). Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. Movement Disorders.  ISSN 0885-3185.  34(12), s 1839- 1850 . doi: 10.1002/mds.27845
• Izzo, Jessica; Andreassen, Ole Andreas; Westlye, Lars Tjelta & van der Meer, Dennis (2019). The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer’s disease. Brain Research.  ISSN 0006-8993.  s 1- 7 . doi: 10.1016/j.brainres.2019.146591
• Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas & Posthuma, Danielle (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics.  ISSN 1061-4036.  51(3), s 404- 413 . doi: 10.1038/s41588-018-0311-9 Full text in Research Archive.
• Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta; Calhoun, Vince D. & Turner, Jessica A. (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder.. NeuroImage: Clinical.  ISSN 2213-1582.  s 1- 9 . doi: 10.1016/j.nicl.2019.101989 Full text in Research Archive.
• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience.  ISSN 1097-6256.  22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Full text in Research Archive.
• Kremen, William S.; Panizzon, Matthew S.; Elman, Jeremy A.; Granholm, Eric L.; Andreassen, Ole Andreas; Dale, Anders; Gillespie, Nathan A.; Gustavson, Daniel E.; Logue, Mark W.; Lyons, Michael J.; Neale, Michael C.; Reynolds, Chandra A.; Whitsel, Nathan & Franz, Carol E. (2019). Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk. Neurobiology of Aging.  ISSN 0197-4580.  83, s 114- 121 . doi: 10.1016/j.neurobiolaging.2019.09.001
• Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2019). Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics.  ISSN 0002-9297.  105(2), s 334- 350 . doi: 10.1016/j.ajhg.2019.06.012 Full text in Research Archive.
• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Brain connectome mapping of complex human traits and their polygenic architecture using machine learning. Biological Psychiatry.  ISSN 0006-3223.  s 1- 10 . doi: 10.1016/j.biopsych.2019.10.011 Full text in Research Archive. Show summary

  Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remains a challenge. Methods In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety and neuroticism using fMRI-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes, and 13 different neuroticism traits and schizophrenia. Results Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism and polygenic scores across traits. Conclusion These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with fMRI-based brain connectomics.

• Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics. Nature Neuroscience.  ISSN 1097-6256. . doi: 10.1101/609586
• Mahmood, Javed Iqbal; Grotmol, Kjersti Støen; Tesli, Martin Steen; Moum, Torbjørn Åge; Andreassen, Ole Andreas & Tyssen, Reidar (2019). Life satisfaction in Norwegian medical doctors: a 15-year longitudinal study of work-related predictors. BMC Health Services Research.  ISSN 1472-6963.  19:729, s 1- 10 . doi: 10.1186/s12913-019-4599-7 Full text in Research Archive.
• Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience.  ISSN 1662-5188.  13 . doi: 10.3389/fncom.2019.00066 Full text in Research Archive.
• Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan; Westlye, Lars Tjelta; Linne, Marja-Leena; Rietschel, Marcella; Schubert, Dirk; Borgwardt, Stefan; Efrim-Budisteanu, Magdalena; Bettella, Francesco; Halnes, Geir; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Edwards, Andrew G.; Metzner, Christoph; Fyhn, Marianne; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry.  ISSN 1664-0640.  10 . doi: 10.3389/fpsyt.2019.00534 Full text in Research Archive.
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex.  ISSN 1047-3211.  29(2), s 875- 891 . doi: 10.1093/cercor/bhy291 Full text in Research Archive.
• Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry.  ISSN 0006-3223.  86(1), s 65- 75 . doi: 10.1016/j.biopsych.2019.01.019 Full text in Research Archive.
• Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew & Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry.  ISSN 0002-953X.  176(8), s 651- 660 . doi: 10.1176/appi.ajp.2019.18080957 Full text in Research Archive.
• Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Andreassen, Ole Andreas; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Børglum, Anders D.; Werge, Thomas & Agerbo, Esben (2019). Association of polygenic liabilities for major depression, bipolar disorder, and schizophrenia with risk for depression in the Danish population. JAMA psychiatry.  ISSN 2168-6238.  76(5), s 516- 525 . doi: 10.1001/jamapsychiatry.2018.4166
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine.  ISSN 0033-2917.  49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Show summary

  Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role

• Nalls, Mike A.; Blauwendraat, Cornelis; Vallerga, Costanza L.; Heilbron, Karl; Bandres-Ciga, Sara; Chang, Diana; Tan, Manuela; Kia, Demis A.; Noyce, Alastair J.; Xue, Angli; Bras, Jose; Young, Emily; von Coelln, Rainer; Simón-Sánchez, Javier; Schulte, Claudia; Sharma, Manu; Krohn, Lynne; Philstrøm, Lasse; Siitonen, Ari; Iwaki, Hirotaka; Leonard, Hampton; Faghri, Faraz; Gibbs, J. Raphael; Hernandez, Dena G.; Scholz, Sonja W.; Botía, Juan A.; Martinez, Maria; Corvol, Jean-Christophe; Lesage, Suzanne; Jankovic, Joseph; Shulman, Lisa M.; Sutherland, Margaret; Tienari, Pentti; Majamaa, Kari; Toft, Mathias; Andreassen, Ole Andreas; Bangale, Tushar; Brice, Alexis; Yang, Jian; Gan-Or, Ziv; Gasser, Thomas; Heutink, Peter; Shulman, Joshua M.; Wood, Nicholas W.; Hinds, David A.; Hardy, John A.; Morris, Huw R.; Gratten, Jacob; Visscher, Peter M.; Graham, Robert R. & Singleton, Andrew B. (2019). Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurology.  ISSN 1474-4422.  18(12), s 1091- 1102 . doi: 10.1016/S1474-4422(19)30320-5
• Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen; Choi, Karmel W.; Coleman, Jonathan R.I.; Dalvie, Shareefa; Duncan, Laramie E.; Gelernter, Joel; Levey, Daniel F.; Logue, Mark W.; Polimanti, Renato; Provost, Allison C.; Ratanatharathorn, Andrew; Stein, Murray B.; Torres, Katy; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Søren B.; Andreassen, Ole Andreas; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Børglum, Anders D.; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Dale, Anders; Daly, Mark J.; Daskalakis, Nikolaos P.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Dzubur-Kulenovic, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Geuze, Elbert; Gillespie, Charles; Uka, Afërdita Goçi; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljevíc, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Junglen, Angela G.; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin E.; Linnstaedt, Sarah D.; Lori, Adriana; Lugonja, Bozo; Luykx, Jurjen Justin; Lyons, Michael J.; Maples-Keller, Jessica; Marmar, Charles; Martin, Alicia R.; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; McLeay, Sarah; Mehta, Divya; Milberg, William P.; Miller, Mark W.; Morey, Rajendra A.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Neale, Benjamin M.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O'Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Ripke, Stephan; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Ken; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley Kurt; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Wolff, Jonathan D.; Yehuda, Rachel; Young, Ross McD.; Young, Keith A.; Zhao, Hongyu; Zoellner, Lori A.; Liberzon, Israel; Ressler, Kerry J.; Haas, Magali & Koenen, Karestan C. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications.  ISSN 2041-1723.  10:4558, s 1- 16 . doi: 10.1038/s41467-019-12576-w Full text in Research Archive.
• O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 11 . doi: 10.1038/s41380-019-0613-z Full text in Research Archive. Show summary

  Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, genetic correlation reported for these disorders is low and non-significant. Here we aimed to better characterize the genetic architecture of these disorders utilizing recent large genome-wide association studies (GWAS). We analyzed independent GWAS summary statistics for ADHD (19,099 cases and 34,194 controls) and BD (20,352 cases and 31,358 controls) applying the conditional/conjunctional false discovery rate (condFDR/conjFDR) statistical framework that increases the power to detect novel phenotype-specific and shared loci by leveraging the combined power of two GWAS. We observed cross-trait polygenic enrichment for ADHD conditioned on associations with BD, and vice versa. Leveraging this enrichment, we identified 19 novel ADHD risk loci and 40 novel BD risk loci at condFDR <0.05. Further, we identified five loci jointly associated with ADHD and BD (conjFDR < 0.05). Interestingly, these five loci show concordant directions of effect for ADHD and BD. These results highlight a shared underlying genetic risk for ADHD and BD which may help to explain the high comorbidity rates and difficulties in differentiating between ADHD and BD in the clinic. Improving our understanding of the underlying genetic architecture of these disorders may aid in the development of novel stratification tools to help reduce these diagnostic difficulties.

• O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, G. Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment. Biological Psychiatry.  ISSN 0006-3223.  87(12), s 1052- 1062 . doi: 10.1016/j.biopsych.2019.11.015 Full text in Research Archive.
• Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Dieset, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Oxytocin pathway gene networks in the human brain. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-08503-8 Full text in Research Archive.
• Rahaman, MA; Turner, Jessica A.; Gupta, Cota Navin; Rachakonda, Srinivas; Chen, Jiayu; Liu, Jingyu; van Erp, Theo G.M.; Potkin, Steven; Ford, Judith; Mathalon, Daniel; Lee, Hyo Jong; Jiang, Wenhao; Mueller, Bryon A; Andreassen, Ole Andreas; Agartz, Ingrid; Sponheim, Scott R.; Mayer, Andrew Robert; Stephen, Julia; Jung, Rex E.; Canive, Jose; Bustillo, Juan R & Calhoun, Vince D. (2019). N-BiC: A Method for Multi-Component and Symptom Biclustering of Structural MRI Data: Application to Schizophrenia.. IEEE Transactions on Biomedical Engineering.  ISSN 0018-9294.  67(1), s 110- 121 . doi: 10.1109/TBME.2019.2908815
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder. Journal of Autism and Developmental Disorders.  ISSN 0162-3257.  s 1- 17 . doi: 10.1007/s10803-019-04112-y Full text in Research Archive.
• Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J.; Holmans, Peter; Legge, Sophie E.; Savage, Jeanne E.; Agartz, Ingrid; Andreassen, Ole Andreas; Blokland, Gabriella A. M.; Corvin, Aiden; Cosgrove, Donna; Degenhardt, Franziska; Djurovic, Srdjan; Espeseth, Thomas; Ferraro, Laura; Gayer-Anderson, Charlotte; Giegling, Ina; van Haren, Neeltje E.M.; Hartmann, Annette M.; Hubert, John J.; Jönsson, Erik Gunnar; Konte, Bettina; Lennertz, Leonhard; Olde Loohuis, Loes M.; Melle, Ingrid; Morgan, Craig; Morris, Derek W.; Murray, Robin M.; Nyman, Håkan; Ophoff, Roel A.; van Os, Jim; Petryshen, Tracey L.; Quattrone, Diego; Rietschel, Marcella; Rujescu, Dan; Rutten, Bart P. F.; Streit, Fabian; Strohmaier, Jana; Sullivan, Patrick F.; Sundet, Kjetil Søren; Wagner, Michael; Escott-Price, Valentina; Owen, Michael J.; Donohoe, Gary; O'Donovan, Michael C. & Walters, James T R (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin.  ISSN 0586-7614. . doi: 10.1093/schbul/sbz061 Show summary

  BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.

• Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry.  ISSN 1664-0640.  10:649, s 1- 8 . doi: 10.3389/fpsyt.2019.00649 Full text in Research Archive.
• Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag & Andreassen, Ole Andreas (2019). GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific Reports.  ISSN 2045-2322.  9 . doi: 10.1038/s41598-019-43458-2 Full text in Research Archive.
• Rødevand, Linn; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna; Mørch, Ragni Helene; Lunding, Synve Hoffart; Vedal, Trude Seselie Jahr; Dieset, Ingrid; Melle, Ingrid; Lagerberg, Trine Vik & Andreassen, Ole Andreas (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139(4), s 348- 360 . doi: 10.1111/acps.13008 Show summary

  Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.

• Sanyal, Nilotpal; Lo, Min-Tzu; Kauppi, Karolina; Djurovic, Srdjan; Andreassen, Ole Andreas; Johnson, Valen E. & Chen, Chi-Hua (2019). GWASinlps: Non-local prior based iterative SNP selection tool for genome-wide association studies. Bioinformatics.  ISSN 1367-4803.  35(1), s 1- 11 . doi: 10.1093/bioinformatics/bty472
• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics.  ISSN 1061-4036.  51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Full text in Research Archive. Show summary

  Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

• Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias; Wolfers, Thomas; Brecheisen, Ralph; Quarto, Tiziana; Ing, Alex J.; di Carlo, Pasquale; Gurholt, Tiril Pedersen; Harms, Robbert L.; Noirhomme, Quentin; Moberget, Torgeir; Agartz, Ingrid; Andreassen, Ole Andreas; Bellani, Marcella; Bertolino, Alessandro; Blasi, Giuseppe; Brambilla, Paolo; Buitelaar, Jan K.; Cervenka, Simon; Flyckt, Lena; Frangou, Sophia; Franke, Barbara; Hall, Jeremy; Heslenfeld, Dirk J.; Kirsch, Peter; McIntosh, Andrew M.; Nöthen, Markus M.; Papassotiropoulos, Andreas; de Quervain, Dominique J.F.; Rietschel, Marcella; Schumann, Gunter; Tost, Heike; Witt, Stephanie H.; Zink, Mathias & Meyer-Lindenberg, Andreas (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  9(12) . doi: 10.1038/s41398-018-0225-4 Full text in Research Archive.
• Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta & Bellivier, Frank (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders.  ISSN 2194-7511.  7(1), s 1- 10 . doi: 10.1186/s40345-019-0156-x Full text in Research Archive.
• Simonsen, Carmen Elisabeth; Aminoff, Sofie Ragnhild; Vaskinn, Anja; Barrett, Elizabeth Ann; Færden, Ann; Ueland, Torill; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2019). Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study. Comprehensive Psychiatry.  ISSN 0010-440X.  95:152134, s 1- 8 . doi: 10.1016/j.comppsych.2019.152134 Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 10 . doi: 10.1038/s41380-018-0332-x Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics.  ISSN 0955-8829.  29(5), s 152- 159 . doi: 10.1097/YPG.0000000000000234 Full text in Research Archive. Show summary

  Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a large number of common variants each with a small effect and many genetic variants influence more than one phenotype, suggesting shared genetic etiology. These concepts have the potential to revolutionize the current classification system with diagnostic categories and facilitate development of better treatments. However, to reach clinical impact, we need larger samples and better analytical tools, as most polygenic factors remain undetected. We here present statistical approaches designed to improve the yield of existing genome-wide association studies for polygenic phenotypes. We review how these tools have informed the current knowledge on the genetic architecture of psychiatric disorders, focusing on schizophrenia, bipolar disorder and major depression, and overlap with psychological and cognitive traits. We discuss application of statistical tools for stratification and prediction.

• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders & Andreassen, Ole Andreas (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics.  ISSN 0340-6717.  s 1- 10 . doi: 10.1007/s00439-019-02060-2 Full text in Research Archive.
• Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring.  ISSN 0163-4356.  41(4), s 503- 508 . doi: 10.1097/FTD.0000000000000619
• Solberg, Dag Kristen; Refsum, Helge; Andreassen, Ole Andreas & Bentsen, Håvard (2019). A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia. Acta Neuropsychiatrica.  ISSN 0924-2708.  31(4), s 202- 212 . doi: 10.1017/neu.2019.14
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John & Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics.  ISSN 1061-4036.  51(5), s 793- 803 . doi: 10.1038/s41588-019-0397-8 Full text in Research Archive.
• Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  17(2) . doi: 10.1017/S0033291719000400 Full text in Research Archive.
• Storvestre, Guttorm Breivik; Valnes, Lars Magnus; Jensen, Arvid; Nerland, Stener; Tesli, Natalia; Hymer, Knut-Erik; Røsæg, Cato; Server, Andres Alonso; Ringen, Petter Andreas; Jacobsen, Morten; Andreassen, Ole Andreas; Agartz, Ingrid; Melle, Ingrid & Haukvik, Unn Kristin H. (2019). A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Research : Neuroimaging.  ISSN 0925-4927.  288, s 29- 36 . doi: 10.1016/j.pscychresns.2019.04.013 Full text in Research Archive.
• Tan, Chin Hong; Bonham, Luke W.; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P.; Broce, Iris J.; Hess, Christopher P.; Yokoyama, Jennifer S.; Rabinovici, Gil D.; Miller, Bruce L.; Yaffe, Kristine; Schellenberg, Gerard D.; Kauppi, Karolina; Holland, Dominic; McEvoy, Linda K.; Kukull, Walter A.; Tosun, Duygu; Weiner, Michael W.; Sperling, Reisa A.; Bennett, David A.; Hyman, Bradley T.; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2019). Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain.  ISSN 0006-8950.  142(2), s 460- 470 . doi: 10.1093/brain/awy327
• Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
• Torske, Tonje; Nærland, Terje; Bettella, Francesco; Bjella, Thomas; Malt, Eva Albertsen; Høyland, Anne Lise; Stenberg, Nina; Øie, Merete Glenne & Andreassen, Ole Andreas (2019). Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment. Autism Research.  ISSN 1939-3792. . doi: 10.1002/aur.2207 Full text in Research Archive. Show summary

  Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5–22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen’s d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R2 = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2019, 00: 1–14. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. Lay Summary: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. Keywords: autism spectrum disorder; polygenic score; executive function; attention deficit/hyperactivity disorder; behavior rating inventory of executive function

• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Cavalleri, Gianpiero L.; Ching, Christopher R.K.; Cichon, Sven; Ciufolini, Simone; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J.C.; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Delanty, Norman; den Braber, Anouk; Desrivieres, Sylvane; di Forti, Marta; Doherty, Joanne L.; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Håberg, Asta; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek; Hillegers, Manon H.J.; Hoffmann, Per; Holleran, Laurena; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jacquemont, Sébastien; Jahanshad, Neda; Jockwitz, Christiane; Johansson, Stefan; Jönsson, Erik Gunnar; Kikuchi, Masataka; Knowles, Emma E.M.; Kwok, John B.; Le Hellard, Stephanie; Linden, David E.J.; Liu, Jingyu; Lundervold, Arvid; Lundervold, Astri; Martin, Nicholas G.; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Moberget, Torgeir; Moreau, Clara; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nordvik, Jan Egil; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomáš; Pausova, Zdenka; Peralta, Juan M.; Pike, Bruce; Prieto, Carlos; Quinlan, Erin Burke; Reinbold, Céline Sonja; Reis Marques, Tiago; Rucker, James J.H.; Sachdev, Perminder S.; Sando, Sigrid Botne; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Steen, Vidar Martin; Stein, Dan J.; Strike, Lachlan T.; Tamnes, Christian Krog; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ülfarsson, Magnús Ö; van 't Ent, Dennis; van den Bree, Marianne B.M.; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Zayats, Tetyana; Dale, Anders; Djurovic, Srdjan; Agartz, Ingrid; Westlye, Lars Tjelta; Stefansson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2019.3779 Show summary

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Vaskinn, Anja; Løvgren, André; Egeland, Maj Kristoffersen; Feyer, Frida Karine; Østefjells, Tiril; Andreassen, Ole Andreas; Melle, Ingrid & Sundet, Kjetil Søren (2019). A randomized controlled trial of training of affect recognition (TAR) in schizophrenia shows lasting effects for theory of mind. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  269(5), s 611- 620 . doi: 10.1007/s00406-019-00997-z Full text in Research Archive.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology.  ISSN 0306-4530.  103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001 Full text in Research Archive.
• Wang, Yunpeng; Karstoft, Karen-Inge; Nievergelt, Caroline M.; Maihofer, Adam X.; Stein, Murray B.; Ursano, Robert J.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Hougaard, David M.; Andreassen, Ole Andreas; Werge, Thomas; Thompson, Wesley Kurt & Andersen, Søren B. (2019). Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations. Journal of Affective Disorders.  ISSN 0165-0327.  252, s 350- 357 . doi: 10.1016/j.jad.2019.04.070
• Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan; Polderman, Tinca J.C.; van der Sluis, Sophie; Andreassen, Ole Andreas; Neale, Benjamin M. & Posthuma, Daniëlle (2019). A global overview of pleiotropy and genetic architecture in complex traits. Nature Genetics.  ISSN 1061-4036.  51(9), s 1339- 1348 . doi: 10.1038/s41588-019-0481-0
• Watson, Hunna J.; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R. I.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole Andreas; Baker, Jessica H; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramis, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Mayora, Monica Gratacos; Guillaume, Sebastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Kaprio, Jaakko; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Klareskog, Lars; Klump, Kelly L.; Knudsen, Gun Peggy S.; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J.; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R.; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Munn-Chernoff, Melissa A.; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K.; Ophoff, Roel A.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W.; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof-Op `t Landt, Margarita C.T.; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A.; van Furth, Eric F.; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W.; Boden, Joseph M.; Brandt, Harry; Crawford, Steven; Halmi, Katherine A.; Horwood, L. John; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Mitchell, James E.; Olsen, Catherine M.; Pearson, John F.; Pedersen, Nancy L.; Strober, Michael; Werge, Thomas; Whiteman, David C.; Woodside, D. Blake; Stuber, Garret D.; Gordon, Scott; Grove, Jakob; Henders, Anjali K.; Juréus, Anders; Kirk, Katherine M.; Larsen, Janne T.; Parker, Richard; Petersen, Liselotte; Jordan, Jennifer; Kennedy, Martin; Montgomery, Grant W.; Wade, Tracey D.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Martin, Nicholas G.; Mortensen, Preben Bo; Sullivan, Patrick F.; Breen, Gerome & Bulik, Cynthia M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics.  ISSN 1061-4036.  51(8), s 1207- 1214 . doi: 10.1038/s41588-019-0439-2
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag; Agartz, Ingrid; Ulven, Stine Marie; Holven, Kirsten Bjørklund; Andreassen, Ole Andreas & Myhre, Anne Margrethe (2019). Lipid alterations in adolescents with early-onset psychosis may be independent of antipsychotic medication. Schizophrenia Research.  ISSN 0920-9964.  s 1- 7 . doi: 10.1016/j.schres.2019.11.039 Full text in Research Archive.
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag; Reponen, Elina Johanna; Lyngstad, Siv Hege; Lekva, Tove; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas; Agartz, Ingrid & Myhre, Anne Margrethe (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology.  ISSN 0306-4530.  112:104513, s 1- 7 . doi: 10.1016/j.psyneuen.2019.104513 Full text in Research Archive.
• Zak, Nathalia; Bøen, Erlend; Boye, Birgitte; Andreassen, Ole Andreas; Doan, Nhat Trung; Malt, Ulrik Fredrik; Westlye, Lars Tjelta & Elvsåshagen, Torbjørn (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders.  ISSN 1398-5647.  21, s 525- 538 . doi: 10.1111/bdi.12771 Full text in Research Archive.
• Kulkarni, Rishikesh U; Vandenberghe, Matthieu; Thunemann, Martin; James, Feroz; Andreassen, Ole Andreas; Djurovic, Srdjan; Devor, Anna & Miller, Evan W (2018). In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes. ACS Central Science.  ISSN 2374-7943.  4(10), s 1371- 1378 . doi: 10.1021/acscentsci.8b00422 Full text in Research Archive.
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Full text in Research Archive.
• Aas, Monica; Djurovic, Srdjan; Ueland, Torill; Mørch, Ragni Helene; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Cattaneo, Annamaria; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid & Andreassen, Ole Andreas (2018). The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders. World Journal of Biological Psychiatry.  ISSN 1562-2975. . doi: 10.1080/15622975.2018.1557345
• Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin; Hughes, Timothy & Djurovic, Srdjan (2018). Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance. Scientific Reports.  ISSN 2045-2322.  8:12654, s 1- 11 . doi: 10.1038/s41598-018-30898-5 Full text in Research Archive.
• Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng; Bettella, Francesco; Moberget, Torgeir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry.  ISSN 2168-6238.  75(3), s 287- 295 . doi: 10.1001/jamapsychiatry.2017.4277
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• Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R.; Pearlson, Godfrey D.; Potkin, Steven G.; Van Erp, Theo G.M.; Macciardi, Fabio; Ehrlich, Stefan; Ho, Beng-Choon; Sponheim, Scott R.; Wang, Lei; Stephen, Julia M.; Mayer, Julia M.; Hanlon, Faith M.; Jung, Rex E.; Clementz, Brett A.; Keshavan, Matcheri S.; Gershon, Elliot S.; Sweeney, John A.; Tamminga, Carol A.; Andreassen, Ole Andreas; Agartz, Ingrid; Westlye, Lars Tjelta; Sui, Jing; Du, Yuhui; Turner, Jessica A. & Liu, Jingyuan (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin.  ISSN 0586-7614.  45(1), s 222- 232 . doi: 10.1093/schbul/sby010
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• de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Thompson, Wesley Kurt; Wang, Yunpeng; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Andreassen, Ole Andreas; Mattingsdal, Morten; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A. & Breen, Gerome (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology.  ISSN 2399-3642.  1(163) . doi: 10.1038/s42003-018-0155-y Full text in Research Archive.
• Demmo, Christine; Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Hellvin, Tone; Simonsen, Carmen Elisabeth; Haatveit, Beathe Almenning; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2018). Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study. Bipolar Disorders.  ISSN 1398-5647.  20(3), s 228- 237 . doi: 10.1111/bdi.12569 Show summary

  OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. METHODS: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first-treatment (FT) BD I patients (N = 42), with and without relapse, during a 1-year follow-up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). RESULTS: Compared to both patients with relapse and healthy controls, no-relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no-relapse patients, reduction of symptoms was associated with neurocognitive improvement. No-relapse patients showed better global and occupational functioning. CONCLUSIONS: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow-up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery.

• Demontis, Ditte; Walters, Raymond K.; Martin, Joanna; Mattheisen, Manuel; Als, Thomas D.; Agerbo, Esben; Baldursson, Gisli; Belliveau, Rich; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Churchhouse, Claire; Dumont, Ashley; Gandal, Michael; Goldstein, Jacqueline I.; Grasby, Katrina L.; Grove, Jakob; Gudmundsson, Ólafur O.; Hansen, Christine S; Hauberg, Mads Engel; Hollegaard, Mads V; Howrigan, Daniel P.; Huang, Hailiang; Jugessur, Astanand; Myhre, Ronny; Stoltenberg, Camilla; Andreassen, Ole Andreas; Asherson, Philip; Burton, Christie L.; Boomsma, Dorret I.; Cormand, Bru; Dalsgaard, Søren; Haavik, Jan; Sonuga-Barke, Edmund J.S.; Sullivan, Patrick F.; Thapar, Anita; Tung, Joyce Y.; Waldman, Irwin; Medland, Sarah E.; Stefansson, Kari; Nordentoft, Merete; Hougaard, David M.; Werge, Thomas; Mors, Ole; Mortensen, Preben Bo; Daly, Mark J.; Faraone, Stephen V.; Børglum, Anders D. & Neale, Benjamin M (2018). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics.  ISSN 1061-4036.  51, s 63- 75 . doi: 10.1038/s41588-018-0269-7 Full text in Research Archive.
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139, s 37- 45 . doi: 10.1111/acps.12971
• Drange, Ole Kristian; Vaaler, Arne; Morken, Gunnar; Andreassen, Ole Andreas; Malt, Ulrik Fredrik & Finseth, Per Ivar (2018). Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study. International journal of bipolar disorders.  ISSN 2194-7511.  6(19) . doi: 10.1186/s40345-018-0128-6 Full text in Research Archive.
• Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha; Chen, Chi-Hua; Kuperman, Joshua M.; Hagler, Donald J.; Steen, Vidar Martin; Le Hellard, Stephanie; Håberg, Asta; Espeseth, Thomas; Andreassen, Ole Andreas; Dale, Anders; Jernigan, Terry L. & Halgren, Eric (2018). Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational Psychiatry.  ISSN 2158-3188.  8:114(1), s 1- 8 . doi: 10.1038/s41398-018-0166-y Full text in Research Archive.
• Fan, Chun Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Chen, Chi-Hua; Holland, Dominic; Lo, Min-Tzu; Sundar, Vijay S.; Frei, Oleksandr; Jernigan, Terry L.; Andreassen, Ole Andreas & Dale, Anders (2018). Beyond heritability: Improving discoverability in imaging genetics. Human Molecular Genetics.  ISSN 0964-6906.  27(1), s R22- R28 . doi: 10.1093/hmg/ddy082
• Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel; Andreassen, Ole Andreas & Spigset, Olav (2018). Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry.  ISSN 0924-9338.  48, s 71- 78 . doi: 10.1016/j.eurpsy.2017.04.001
• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg; Dieset, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid; Marder, Stephen R. & Melle, Ingrid (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research.  ISSN 0165-1781.  267, s 140- 147 . doi: 10.1016/j.psychres.2018.05.065 Full text in Research Archive.
• Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid & Steen, Vidar Martin (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  197, s 253- 260 . doi: 10.1016/j.schres.2017.10.042 Full text in Research Archive. Show summary

  Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

• Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Vidar Martin & Agartz, Ingrid (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging.  ISSN 0925-4927.  282, s 55- 63 . doi: 10.1016/j.pscychresns.2018.10.001
• Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  269(7), s 795- 802 . doi: 10.1007/s00406-018-0897-z Full text in Research Archive.
• Gurholt, Tiril Pedersen; Osnes, Kåre; Nerhus, Mari; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-29141-y Full text in Research Archive.
• Hartberg, Cecilie Bhandari; Lange, Elisabeth Heffermehl; Lagerberg, Trine Vik; Haukvik, Unn Kristin H.; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use. European Neuropsychopharmacology.  ISSN 0924-977X.  28(1), s 37- 47 . doi: 10.1016/j.euroneuro.2017.11.019
• Hibar, Derrek; Westlye, Lars Tjelta; Doan, Nhat Trung; Jahanshad, Neda; Cheung, J. W.; Ching, Christopher R K; Versace, Amelia; Bilderbeck, A; Uhlmann, Anne; Mwangi, B; Krämer, B; Overs, B; Hartberg, Cecilie Bhandari; Abé, Christoph; Dima, Danai; Grotegerd, Dominik; Sprooten, Emma; Bøen, Erlend; Jimenez, Enrique; Howells, Fleur M.; Delvecchio, G; Temmingh, H; Starke, J; Almeida, JRC; Goikolea, JM; Houenou, J; Beard, Lauren M.; Rauer, L; Abramovic, Lucija; Bonnin, M.; Ponteduro, MF; Keil, M; Rive, MM; Yao, N; Yalin, N; Najt, P; Rosa, PG; Redlich, Ronny; Trost, S; Hagenaars, Saskia; Fears, SC; Alonso-Lana, S; Van Erp, TGM; Nickson, Thomas; Chaim-Avancini, TM; Meier, TB; Elvsåshagen, Torbjørn; Haukvik, Unn Kristin H.; Lee, Who-Seung; Schene, AH; Lloyd, AJ; Young, AH; Nugent, Allison C; Dale, AM; Pfennig, Andrea; McIntosh, AM; Lafer, Beny; Baune, BT; Ekman, CJ; Zarate, CA; Bearden, CE; Henry, C; Simhandl, Christian; McDonald, C; Bourne, C; Stein, DJ; Wolf, DH; Cannon, DM; Glahn, DC; Veltman, DJ; Pomarol-Clotet, E; Vieta, E; Canales-Rodriguez, EJ; Nery, FG; Duran, FLS; Busatto, GF; Roberts, G; Pearlson, GD; Goodwin, GM; Kugel, H; Whalley, HC; Ruhe, HG; Soares, JC; Fullerton, JM; Rybakowski, JK; Savitz, Jonathan; Chaim, KT; Fatjo-Vilas, Mar; Soeiro-de-Souza, MG; Boks, MP; Zanetti, MV; Otaduy, MCG; Schaufelberger, MS; Alda, Martin; Ingvar, Martin; Phillips, ML; Kempton, MJ; Bauer, M; Landén, M; Lawrence, NS; Van Haren, NEM; Horn, NR; Freimer, NB; Gruber, Oliver; Schofield, PR; Mitchell, PB; Kahn, RS; Lenroot, R; Machado-Vieira, R; Ophoff, RA; Sarró, S; Frangou, Sophia; Satterthwaite, TD; Hajek, Tomas; Dannlowski, Udo; Malt, Ulrik Fredrik; Arolt, Volker; Gattaz, WF; Drevets, WC; Caseras, Xavier; Agartz, Ingrid; Thompson, PM & Andreassen, Ole Andreas (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry.  ISSN 1359-4184.  23, s 932- 942 . doi: 10.1038/mp.2017.73 Full text in Research Archive.
• Holmen, Tom Langerud; Engh, John; Andersen, Eivind; Andreassen, Ole Andreas; Martinsen, Egil Wilhelm; Bigseth, Therese Torgersen; Bang-Kittilsen, Gry & Egeland, Jens (2018). Cardio-respiratory fitness is associated with a verbal factor across cognitive domains in schizophrenia. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.11.033 Full text in Research Archive. Show summary

  Abstract Objective We investigated whether the relationship between cardio-respiratory fitness (CRF) and cognition in schizophrenia is general, or due to selective relationships between CRF and specific aspects of cognitive function. Method Eighty outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale version 4 General Ability Index (WAIS GAI), the MATRICS Consensus Cognitive Battery (MCCB) and the Emotion in Biological Motion (EBM) test. CRF was assessed with peak oxygen uptake measured directly during maximum exercise using a modified Balke protocol. Partial correlations, controlling for sex and age, were obtained for the perceptual and the verbal indices of WAIS GAI, six cognitive domains of MCCB, and the EBM total score. A factor analysis was conducted on all 15 subtests of the WAIS GAI and the MCCB, and the factors were subjected to separate regression analyses with CRF as predictor. Results Significant, moderately sized correlations were found between CRF and all cognitive domains except processing speed. The correlation appeared strongest for CRF and the Verbal Comprehension Index of WAIS GAI (r = 0.29, p = .005). The factor analysis identified three factors: one speed/attention/executive function factor, one verbal factor, and one perceptual factor. Regression analyses showed that VO2peak explained a significant amount of variance in the verbal factor only (R2 = 0.06, β = 0.329, p = .03). Conclusion The results indicate that the relationship between CRF and cognition in schizophrenia is selectively tied to a modality-specific association with verbal cognitive abilities. These findings have implications for understanding the relation between cognitive factors and physical health in schizophrenia.

• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Full text in Research Archive.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Full text in Research Archive.
• Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn; Athanasiu, Lavinia; Melbø-Jørgensen, Christian; Hassani, Sahar; Hoeffding, Louise K.; Herms, Stefan; Bergen, Sarah E.; Karlsson, Robert; Song, Jie; Rietschel, Marcella; Nöthen, Markus M.; Forstner, Andreas J.; Hoffmann, Per; Hultman, Christina M.; Landén, Mikael; Cichon, Sven; Werge, Thomas; Andreassen, Ole Andreas; Le Hellard, Stephanie & Djurovic, Srdjan (2018). Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  8(210), s 1- 10 . doi: 10.1038/s41398-018-0175-x Full text in Research Archive.
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
• Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep.  ISSN 0161-8105.  41(10) . doi: 10.1093/sleep/zsy145 Full text in Research Archive.
• Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Yokoyama, Jennifer S.; Kouri, Naomi; Ross, Owen A.; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Schellenberg, Gerard D.; Sleiman, Patrick M.; Momeni, Parastoo; Hess, Christopher P.; Miller, Bruce L.; Sharma, Manu; Van Deerlin, Vivianna M.; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2018). Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum. JAMA Neurology.  ISSN 2168-6149.  75(7), s 860- 875 . doi: 10.1001/jamaneurol.2018.0372
• Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2018.0844
• Kauppi, Karolina; Fan, Chun Chieh; McEvoy, Linda K.; Holland, Dominic; Tan, Chin Hong; Chen, Chi-Hua; Andreassen, Ole Andreas; Desikan, Rahul S. & Dale, Anders M. (2018). Combining polygenic hazard score with volumetric MRI and cognitive measures improves prediction of progression from mild cognitive impairment to Alzheimer's disease. Frontiers in Neuroscience.  ISSN 1662-4548.  12 . doi: 10.3389/fnins.2018.00260 Full text in Research Archive.
• Kauppi, Karolina; rosenthal, sara brin; Lo, Min-Tzu; Sanyal, Nilotpal; Jiang, Mian; Abagyan, Ruben; McEvoy, Linda K.; Andreassen, Ole Andreas & Chen, Chi-Hua (2018). Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia. American Journal of Psychiatry.  ISSN 0002-953X.  175(7), s 674- 682 . doi: 10.1176/appi.ajp.2017.17040410 Full text in Research Archive.
• Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid; Alloza, C; Andreassen, Ole Andreas; Arango, C; Banaj, Nerisa; Bouix, S; Bousman, CA; Brouwer, RM; Bruggemann, J; Bustillo, Juan R; Cahn, Wiepke; Calhoun, Vince; Cannon, Dara M; Carr, Vaughan J.; Catts, Stanley V.; Chen, J; Chen, JX; Chen, X; Chiapponi, C; Cho, KK; Ciullo, Valentina; Corvin, A; Crespo-Facorro, Benedicto; Cropley, V; De Rossi, Pietro; Diaz-Caneja, CM; Dickie, EW; Ehrlich, S; Fan, FM; Faskowitz, Joshua; Fatouros-Bergman, Helena; Flyckt, Lena; Ford, JM; Fouche, JP; Fukunaga, Masaki; Gill, M; Glahn, DC; Gollub, Randy L; Goudzwaard, ED; Guo, H; Gur, RE; Gur, RC; Gurholt, Tiril Pedersen; Hashimoto, Ryota; Hatton, SN; Henskens, FA; Hibar, DP; Hickie, IB; Hong, LE; Horacek, Jan; Howells, FM; Hulshoff Pol, Hilleke E; Hyde, CL; Isaev, D; Jablensky, Assen; Jansen, PR; Janssen, J; Jönsson, Erik Gunnar; Jung, LA; Kahn, RS; Kikinis, Z; Liu, K; Klauser, Paul; Knöchel, C; Kubicki, M; Lagopoulos, Jim; Langen, C; Lawrie, Stephen M; Lenroot, R; Lim, KO; Lopez-Jaramillo, Carlos; Lyall, A; Magnotta, V; Mandl, RCW; Mathalon, DH; McCarley, RW; McCarthy-Jones, Simon; McDonald, C; McEwen, S; McIntosh, A; Melicher, T; Mesholam-Gately, RI; Michie, PT; Mowry, Bryan J.; Mueller, BA; Newell, DT; O'donnell, P; Oertel-Knöchel, V; Oestreich, L; Paciga, SA; Pantelis, Christos; Pasternak, O; Pearlson, Godfrey D; Pellicano, GR; Pereira, A; Pineda Zapata, J; Piras, Fabrizio; Potkin, SG; Preda, Adrian; Rasser, PE; Roalf, DR; Roiz, R; Roos, A; Rotenberg, D; Satterthwaite, TD; Savadjiev, P; Schall, Ulrich; Scott, RJ; Seal, ML; Seidman, LJ; Shannon Weickert, C; Whelan, CD; Shenton, ME; Kwon, JS; Spalletta, Gianfranco; Spaniel, F; Sprooten, Emma; Stäblein, M; Stein, DJ; Sundram, S; Tan, Y; Tan, S; Tang, S; Temmingh, HS; Westlye, Lars Tjelta; Tønnesen, Siren; Tordesillas-Gutierrez, Diana; Doan, Nhat Trung; Vaidya, Jatin G.; Van Haren, NEM; Vargas, CD; Vecchio, D; Velakoulis, D; Voineskos, Aristotle N.; Voyvodic, JQ; Wang, Z; Wan, P; Wei, D; Weickert, TW; Whalley, Heather Clare; White, T; Whitford, TJ; Wojcik, JD; XIANG, HUA; Xie, Z; Yamamori, Hidenaga; Yang, F; Yao, N; Zhang, G.; Zhao, J; Van Erp, Theo G M; Turner, J; Thompson, PM & Donohoe, Gary (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry.  ISSN 1359-4184.  23, s 1261- 1269 . doi: 10.1038/mp.2017.170 Full text in Research Archive.
• Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Moberget, Torgeir; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro.  ISSN 2373-2822.  5(4), s 1- 13 . doi: 10.1523/ENEURO.0092-18.2018 Full text in Research Archive.
• Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
• Kvam, Tor-Morten; Stewart, Lowan H. & Andreassen, Ole Andreas (2018). Psykedeliske stoffer i behandling av angst, depresjon og avhengighet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(18) . doi: 10.4045/tidsskr.17.1110
• LeBlanc, Marissa; Zuber, Verena; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Frigessi Di Rattalma, Arnoldo & Kulle, Bettina (2018). A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework. BMC Genomics.  ISSN 1471-2164.  19:494, s 1- 15 . doi: 10.1186/s12864-018-4859-7 Full text in Research Archive.
• Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Wang, Yunpeng (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  ISSN 1552-4841.  177(4), s 454- 467 . doi: 10.1002/ajmg.b.32634
• Li, Yi; Barkovich, Matthew J.; Karch, Celeste M.; Nillo, Ryan M.; Fan, Chun-Chieh; Broce, Iris J.; Tan, Chin Hong; Cuneo, Daniel; Hess, Christopher P.; Dillon, William P.; Glenn, Orit A.; Glastonbury, Christine M.; Olney, Nicholas; Yokoyama, Jennifer S.; Bonham, Luke W.; Miller, Bruce; Kao, Aimee; Schmansky, Nicholas; Fischl, Bruce; Andreassen, Ole Andreas; Jernigan, Terry; Dale, Anders; Barkovich, A. James; Desikan, Rahul S. & Sugrue, Leo P. (2018). Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Scientific Reports.  ISSN 2045-2322.  8:13373, s 1- 10 . doi: 10.1038/s41598-018-31075-4 Full text in Research Archive.
• Logue, Mark W.; Panizzon, Matthew S.; Elman, Jeremy A.; Gillespie, Nathan A.; Hatton, Sean N.; Gustavson, Daniel E.; Andreassen, Ole Andreas; Dale, Anders; Franz, Carol E.; Lyons, Michael J.; Neale, Michael C.; Reynolds, Chandra A.; Tu, Xin & Kremen, William S. (2018). Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 10 . doi: 10.1038/s41380-018-0030-8
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Metzner, Christoph; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2018). A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. Journal of Neuroscience Methods.  ISSN 0165-0270.  293, s 264- 283 . doi: 10.1016/j.jneumeth.2017.10.007 Full text in Research Archive.
• McCarthy, Michael J.; Wei, Heather; Nievergelt, Caroline M.; Stautland, Andrea; Maihofer, Adam X.; Welsh, David K; Shilling, Paul D.; Alda, Martin; Alley-Rodriguez, Ney; Anand, Anit; Andreassen, Ole Andreas; Balaraman, Yokesh; Berrettini, Wade H; Bertram, Holli; Brennand, Kristen J.; Calabrese, Joseph R.; Calkin, Cynthia V.; Claasen, Ana; conroy, Clara; Coryell, William H.; Craig, David; D´Arcangelo, Nicole; DeModena, Anna; Djurovic, Srdjan; Feeder, Scott; Gage, Fred H.; Jakobsen, Petter; Karberg, Elizabeth; Kelly, Marissa; Leckband, Susan G.; Lohoff, Falk; McInnis, Melvin G.; Mondimore, Francis; Morken, Gunnar; Nurnberger, John I.; Obral, Sarah; Ødegaard, Ketil Joachim; Ortiz, Abigail; Ritchey, Megan; Ryan, Kelly; Schinagle, Martha; Schøyen, Helle Kristine; Schwebel, Candice; Shaw, Martha; Shekhtman, Tatyana; Slaney, Clare; Stapp, Emma; Szelinger, Szabolcs; Tarwater, Bruce; Zandi, Peter P. & Kelsoe, John R. (2018). Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology.  ISSN 0893-133X.  44(3), s 620- 628 . doi: 10.1038/s41386-018-0273-8 Full text in Research Archive. Show summary

  Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patients, we measured circadian rhythms in fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-R patients were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP3 signaling pathway may account for some of the individual differences in the effects of lithium on cellular rhythms. We conclude that circadian rhythms may influence response to lithium in maintenance treatment of BD.

• Mørch-Johnsen, Lynn; Nerland, Stener; Jørgensen, Kjetil Nordbø; Osnes, Kåre; Hartberg, Cecilie Bhandari; Andreassen, Ole Andreas; Melle, Ingrid; Nesvåg, Ragnar & Agartz, Ingrid (2018). Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. Bipolar Disorders.  ISSN 1398-5647.  20(7), s 647- 657 . doi: 10.1111/bdi.12627
• Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid; Andreassen, Ole Andreas & Jönsson, Erik Gunnar (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-28160-z Full text in Research Archive.
• Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir; Rokicki, Jaroslav; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.09.027 Full text in Research Archive.
• Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodriguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine Vik; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Mwangi, Benson; Nabulsi, Leila; Opel, Nils; Overs, Bronwyn J.; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Redlich, Ronny; Roberts, Gloria; Rosa, Pedro G.; Salvador, Raymond; Satterthwaite, Theodore D.; Soares, Jair C.; Stein, Dan J.; Temmingh, Henk S.; Trappenberg, Thomas; Uhlmann, Anne; van Haren, Neeltje E.M.; Vieta, Eduard; Westlye, Lars Tjelta; Wolf, Daniel H.; Yüksel, Dilara; Zanetti, Marcus V.; Andreassen, Ole Andreas; Thompson, Paul M. & Hájek, Tomás (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry.  ISSN 1359-4184. . doi: 10.1038/s41380-018-0228-9 Full text in Research Archive.
• Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E.; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L.; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H.; McCarroll, Steven A.; Baune, Bernhard T.; Breen, Gerome; Byrne, Enda M.; Dannlowski, Udo; Eley, Thalia C.; Hayward, Caroline; Martin, Nicholas G.; McIntosh, Andrew M.; Plomin, Robert; Porteous, David J.; Wray, Naomi R.; Caballero, Armando; Geschwind, Daniel H.; Huckins, Laura M.; Ruderfer, Douglas M.; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A.; Won, Hyejung; Agerbo, Esben; Als, Thomas D.; Andreassen, Ole Andreas; Bækvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bøcker; Børglum, Anders D.; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giørtz; Golimbet, Vera; Grove, Jakob; Hougaard, David M.; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Søholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; Collier, David A; Owen, Michael J; O'Donovan, Michael C; Walters, James T R; Collier, David A.; Rujescu, Dan; Kirov, George; Owen, Michael J.; O'Donovan, Michael C. & Walters, James T.R. (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics.  ISSN 1061-4036.  50(3), s 381- 389 . doi: 10.1038/s41588-018-0059-2
• Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alxander W.; Ori, Anil P.S.; Domenici, Enrico; Di Florio, A; Papiol, S; Kalman, Janos; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Joa, Inge; Malt, Ulrik Fredrik; Mattingsdal, Morten; Melle, Ingrid; Morken, Gunnar; Nordentoft, Merete; Nordin, Annelie; Ødegaard, Ketil Joachim; Smeland, Olav Bjerkehagen; Stordal, Eystein; Vaaler, Arne; Wang, Yunpeng; Zheng, Xuebin; Zimprich, Fritz; Zöllner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole Andreas; Hong Lee, S; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela & Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.. Cell.  ISSN 0092-8674.  173(7), s 1705- 1715 . doi: 10.1016/j.cell.2018.05.046
• Quintana, Daniel; Smerud, Knut Terje; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Evidence for intranasal oxytocin delivery to the brain: Recent advances and future perspectives. Therapeutic delivery.  ISSN 2041-5990.  9(7), s 515- 525 . doi: 10.4155/tde-2018-0002 Full text in Research Archive.
• Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Kaufmann, Tobias; Mahmoud, Ramy A.; Smerud, Knut Terje; Djupesland, Per G. & Andreassen, Ole Andreas (2018). Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study. Neuropsychopharmacology.  ISSN 0893-133X.  44, s 306- 313 . doi: 10.1038/s41386-018-0241-3
• Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut Terje; Mahmoud, Ramy A.; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior.  ISSN 0018-506X.  102, s 85- 92 . doi: 10.1016/j.yhbeh.2018.05.004
• Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders; Doan, Nhat Trung; Monereo Sanchez, Jennifer; Alnæs, Dag; Ulrichsen, Kristine Moe; Dørum, Erlend Solberg; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ.  ISSN 2167-8359. . doi: 10.7717/peerj.5908 Full text in Research Archive. Show summary

  Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequately characterized. Exploring differential brain age models driven by tissue- specific classifiers provides a hitherto unexplored opportunity to disentangle indepen- dent sources of heterogeneity in brain biology. We trained machine-learning models to estimate brain age using various combinations of FreeSurfer based morphometry and diffusion tensor imaging based indices of white matter microstructure in 612 healthy controls aged 18–87 years. To compare the tissue-specific brain ages and their cognitive sensitivity, we applied each of the 11 models in an independent and cognitively well- characterized sample ( n = 265, 20–88 years). Correlations between true and estimated age and mean absolute error (MAE) in our test sample were highest for the most comprehensive brain morphometry ( r = 0 . 83, CI:0.78–0.86, MAE = 6.76 years) and white matter microstructure ( r = 0 . 79, CI:0.74–0.83, MAE = 7.28 years) models, confirming sensitivity and generalizability. The deviance from the chronological age were sensitive to performance on several cognitive tests for various models, including spatial Stroop and symbol coding, indicating poorer performance in individuals with an over-estimated age. Tissue-specific brain age models provide sensitive measures of brain integrity, with implications for the study of a range of brain disorders.

• Ringen, Petter Andreas; Falk, Ragnhild Sørum; Antonsen, Bjørnar Torske; Færden, Ann; Mamen, Asgeir; Rognli, Eline Borger; Solberg, Dag Kristen; Martinsen, Egil Wilhelm & Andreassen, Ole Andreas (2018). Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: A naturalistic interventional study. BMC Psychiatry.  ISSN 1471-244X.  18 . doi: 10.1186/s12888-018-1832-6 Full text in Research Archive.
• Ringen, Petter Andreas; Færden, Ann; Antonsen, Bjørnar Torske; Falk, Ragnhild Sørum; Mamen, Asgeir; Rognli, Eline Borger; Solberg, Dag Kristen; Andreassen, Ole Andreas & Martinsen, Egil Wilhelm (2018). Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-term psychiatric inpatient departments. Nordic Journal of Psychiatry.  ISSN 0803-9488.  72(4), s 296- 302 . doi: 10.1080/08039488.2018.1449012 Full text in Research Archive.
• Rosenvinge, Jan H; Andreassen, Ole Andreas & Rø, Øyvind (2018). Spiseforstyrrelser, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.),  Lærebok i psykiatri.  Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  Kapittel 19.  s 571 - 598
• Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A.; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B.; Coleman, Jonathan R.I.; Grasby, Katrina L.; Hammerschlag, Anke R.; Kaminski, Jakob A.; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A.; Trampush, Joey W.; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K.; Karlsson, Ida K.; Linnarsson, Sten; Montgomery, Grant W.; Muñoz-Manchado, Ana B.; Quinlan, Erin B.; Schumann, Gunter; Skene, Nathan G.; Webb, Bradley T.; White, Tonya; Arking, Dan E.; Avramopoulos, Dimitrios; Bilder, Robert M.; Bitsios, Panos; Burdick, Katherine E.; Cannon, Tyrone D.; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T.; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J.; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G.; Espeseth, Thomas; Freimer, Nelson A.; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C.; Hariri, Ahmad; Hatzimanolis, Alex; Keller, Matthew C.; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C.; London, Edythe; Lundervold, Astri; Malhotra, Anil K.; Melle, Ingrid; Morris, Derek; Need, Anna C.; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A.; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W.; Scult, Matthew A; Smeland, Olav Bjerkehagen; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar Martin; Stefanis, Nikos C.; Straub, Richard E.; Sundet, Kjetil Søren; Tiemeier, Henning; Voineskos, Aristotle N.; Weinberger, Daniel R.; Widén, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole Andreas; Breen, Gerome; Christiansen, Lene; Debrabant, Birgit; Dick, Danielle M.; Heinz, Andreas; Hjerling-Leffler, Jens; Ikram, M. Arfan; Kendler, Kenneth S.; Martin, Nicholas G.; Medland, Sarah E.; Pedersen, Nancy L.; Plomin, Robert; Polderman, Tinca J.C.; Ripke, Stephan; van der Sluis, Sophie; Sullivan, Patrick F.; Vrieze, Scott I; Wright, Margaret J. & Posthuma, Daniëlle (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics.  ISSN 1061-4036.  50, s 912- 919 . doi: 10.1038/s41588-018-0152-6
• Seibert, Tyler M.; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Parsons, J. Kellogg; Eeles, Rosalind A.; Easton, Douglas F.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Garcia, Sara Benlloch; Muir, Kenneth; Grönberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; Tammela, Teuvo L.J.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weischer, Maren; Bisbjerg, Rasmus; Røder, M. Andreas; Iversen, Peter; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Cuk, Katarina; Saum, Kai-Uwe; Park, Jong Y.; Sellers, Thomas A.; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Clements, Judith A.; Spurdle, Amanda; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Karow, David S.; Mills, Ian Geoffrey; Andreassen, Ole Andreas & Dale, Anders (2018). Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ. British Medical Journal.  ISSN 1756-1833.  360:j5757, s 1- 7 . doi: 10.1136/bmj.j5757 Full text in Research Archive.
• Simonsen, Carmen Elisabeth; Færden, Ann; Ueland, Torill; Vaskinn, Anja; Bjella, Thomas; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2018). Self-rated disability in first treated episode of psychosis: A 1-year follow-up study. Comprehensive Psychiatry.  ISSN 0010-440X.  85, s 48- 54 . doi: 10.1016/j.comppsych.2018.06.004 Full text in Research Archive.
• Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?. Scandinavian Journal of Psychology.  ISSN 0036-5564.  59(1), s 26- 31 . doi: 10.1111/sjop.12407
• Smelror, Runar; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Kelleher, Ian; Cannon, Mary; DeRosse, Pamela; Malhotra, Anil K.; Karlsgodt, Katherine H. ; Andreassen, Ole Andreas; Lundberg, Mathias; Edbom, Tobias; Cleland, Neil; Ueland, Torill; Myhre, Anne Margrethe; Rund, Bjørn Rishovd & Agartz, Ingrid (2018). Healthy adolescent performance with standardized scoring tables for the MATRICS Consensus Cognitive Battery: A multisite study. Schizophrenia Bulletin.  ISSN 0586-7614.  45(4), s 773- 783 . doi: 10.1093/schbul/sby131
• Smoller, Jordan W.; Andreassen, Ole Andreas; Edenberg, Howard J.; Faraone, Stephen V.; Glatt, Stephen J. & Kendler, Kenneth Seedman (2018). Psychiatric genetics and the structure of psychopathology. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 12 . doi: 10.1038/s41380-017-0010-4
• Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke; Berg-Hansen, Pål; Moen, Stine Marit; Bjørnerud, Atle; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Dale, Anders & Beyer, Mona K. (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis.  ISSN 1352-4585.  s 1- 12 . doi: 10.1177/1352458518765671 Full text in Research Archive.
• Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports.  ISSN 2045-2322.  8:12585, s 1- 9 . doi: 10.1038/s41598-018-30387-9 Full text in Research Archive.
• Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E.; Sullivan, Patrick F.; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M. & Steen, Vidar Martin (2018). Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes. Scientific Reports.  ISSN 2045-2322.  8(6915), s 1- 8 . doi: 10.1038/s41598-018-25280-4 Full text in Research Archive.
• Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra; Espeseth, Thomas; Vaskinn, Anja; Wang, Yunpeng; Westlye, Lars Tjelta; Jacquemont, Sébastien; Djurovic, Srdjan; Stefánsson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 16 . doi: 10.1038/s41380-019-0358-8 Full text in Research Archive.
• Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle; Vandenberghe, Matthieu; Sadegh, Sanaz; Saisan, Payam A.; Cheng, Qun; Weldy, Kimberly L.; Lyu, Hongming; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Devor, Anna & Kuzum, Duygu (2018). Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nature Communications.  ISSN 2041-1723.  9:2015, s 1- 12 . doi: 10.1038/s41467-018-04457-5 Full text in Research Archive.
• Torske, Tonje; Nærland, Terje; Øie, Merete Glenne; Stenberg, Nina & Andreassen, Ole Andreas (2018). Metacognitive aspects of executive function are highly associated with social functioning on parent-rated measures in children with Autism Spectrum Disorder. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  11 . doi: 10.3389/fnbeh.2017.00258 Full text in Research Archive.
• Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-32355-9 Full text in Research Archive.
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 13 . doi: 10.1038/s41380-018-0262-7 Full text in Research Archive.
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C.; Pearlson, Godfrey D.; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R.; Clark, Vincent P.; Agartz, Ingrid; Mueller, Bryon A.; Cahn, Wiepke; de Zwarte, Sonja M.C.; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ophoff, Roel A.; van Haren, Neeltje E.M.; Andreassen, Ole Andreas; Dale, Anders; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Jørgensen, Kjetil Nordbø; Lagerberg, Trine Vik; Melle, Ingrid; Westlye, Lars Tjelta; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D.; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J.; Catts, Stanley; Cropley, Vanessa L.; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans A.; Jablensky, Assen; Lenroot, Rhoshel K.; Mowry, Bryan J.; Michie, Patricia T.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J.; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; Shannon Weickert, Cynthia; Weickert, Thomas W.; Morris, Derek W.; Hong, Elliot; Kochunov, Peter; Beard, Lauren M.; Gur, Raquel E.; Gur, Ruben C.; Satterthwaite, Theodore D; Wolf, Daniel H.; Belger, Aysenil; Brown, Gregory G.; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel H.; O'Leary, Daniel S.; Potkin, Steven G.; Preda, Adrian; Voyvodic, James; Lim, Kelvin O.; McEwen, Sarah; Yang, Fude; Tan, Yunlong; Tan, Shuping; Wang, Zhiren; Fan, Fengmei; Chen, Jingxu; Xiang, Hong; Tang, Shiyou; Guo, Hua; Wan, Ping; Wei, Dong; Bockholt, Henry J.; Ehrlich, Stefan; Wolthusen, Rick P.F.; King, Margaret D.; Shoemaker, Jody M.; Sponheim, Scott R.; De Haan, Lieuwe; Koenders, Laura; Machielsen, Marise W.; van Amelsvoort, Therese; Veltman, Dick J.; Assogna, Francesca; Banaj, Nerisa; de Rossi, Pietro; Iorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; McKenna, Peter J.; Pomarol-Clotet, Edith; Salvador, Raymond; Corvin, Aiden; Donohoe, Gary; Kelly, Sinead; Whelan, Christopher D.; Dickie, Erin W.; Rotenberg, David; Voineskos, Aristotle N.; Ciufolini, Simone; Radua, Joaquim; Dazzan, Paola; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; Egloff, Laura; Harrisberger, Fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; Wang, Lei; Jönsson, Erik Gunnar; Koops, Sanne; Sommer, Iris Else Clara; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Stephen, Julia M.; Kwon, Jun Soo; Yun, Je-Yeon; Cannon, Dara M.; McDonald, Colm; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; Fatouros-Bergman, Helena & Flyckt, Lena (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.04.023 Full text in Research Archive.
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; wenhao, jiang; Glahn, David C; Pearlson, Godfrey D; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Clark, Vincent P; Mueller, Bryon A; de Zwarte, Sonja M.C.; Ophoff, Roel A; Van Haren, Neeltje E M; Andreassen, Ole Andreas; Gurholt, Tiril Pedersen; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Calhoun, Vince D; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; tordesillas-guiterrez, diana; Loughland, Carmel M; Catts, Stanley; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans; Jablensky, Assen; Mowry, Bryan J.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; weickert, cynthia; Weickert, Thomas W.; Hong, Elliot; Kochunov, Peter; Gur, Raquel E; Gur, Ruben C; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel; Potkin, Steven G; Preda, Adrian; Fan, Fengmei; Ehrlich, Stefan; King, Margaret D.; De Haan, Lieuwe; Veltman, Dick J; Assogna, Francesca; Banaj, Nerisa; De Rossi, Pietro; Lorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; Pomarol-Clotet, Edith; Kelly, Sinéad; Ciufollini, Simone; Radua, Joaquim; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; schonborn-harrisberger, fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; bertolino, allessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Yun, Je-Yeon; Cannon, Dara M; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; fatouros-bergmann, helena; Flyckt, Lena; Farde, Lars; Cervenka, Simon; Agartz, Ingrid; Collste, Karin; Victorsson, Pauliina; Engberg, Göran; Erhardt, Sophie; Schwieler, Lilly; Malmqvist, Anna; Hedberg, Mikael; Orhan, Funda; Piehl, Fredrik; Rosa, Pedro GP; Serpa, Mauricio H; Zanetti, Marcus V; Hoschl, Cyril; Škoch, Antonín; Spaniel, Filip; Tomecek, David; McIntosh, Andrew M.; Whalley, Heather C; Knochel, Christian; oertel-knöchel, viola; Howells, Fleur M; Stein, Dan J.; Temmingh, Henk S.; Uhlmann, Anne; Lopez-Jaramillo, Carlos; Dima, Danai; Faskowitz, Joshua I; Gutman, Boris A; Jahanshad, Neda; Thompson, Paul M & Turner, Jessica A (2018). Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.10.003
• Vaskinn, Anja; Andersson, Stein; Østefjells, Tiril; Andreassen, Ole Andreas & Sundet, Kjetil Søren (2018). Emotion perception, non-social cognition and symptoms as predictors of theory of mind in schizophrenia. Comprehensive Psychiatry.  ISSN 0010-440X.  85, s 1- 7 . doi: 10.1016/j.comppsych.2018.05.002 Full text in Research Archive.
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research.  ISSN 0022-3956.  106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
• Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole Andreas; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, André G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomáš; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, William T.; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M. Arfan & Fornage, Myriam (2018). Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications.  ISSN 2041-1723.  9:3945, s 1- 11 . doi: 10.1038/s41467-018-06234-w Full text in Research Archive.
• Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine.  ISSN 0033-2917.  48(1), s 82- 94 . doi: 10.1017/S0033291717001283 Full text in Research Archive.
• Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fred; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod & Andreassen, Ole Andreas (2018). Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-36429-6 Full text in Research Archive.
• Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir; Agartz, Ingrid; Buitelaar, Jan K.; Ueland, Torill; Melle, Ingrid; Franke, Barbara; Andreassen, Ole Andreas; Beckmann, Christian F.; Westlye, Lars Tjelta & Marquand, André F. (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry.  ISSN 2168-6238.  75(11), s 1146- 1155 . doi: 10.1001/jamapsychiatry.2018.2467
• Zak, Nathalia; Moberget, Torgeir; Bøen, Erlend; Boye, Birgitte; Waage, Trine Rygvold; Dietrichs, Espen; Harkestad, Nina; Malt, Ulrik Fredrik; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Andersson, Stein & Elvsåshagen, Torbjørn (2018). Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals. Translational Psychiatry.  ISSN 2158-3188.  8(103) . doi: 10.1038/s41398-018-0151-5 Full text in Research Archive.
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bézieau, Stéphane; Dale, Anders; Mills, Ian Geoffrey & Andreassen, Ole Andreas (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports.  ISSN 2045-2322.  674(8), s 1- 8 . doi: 10.1038/s41598-017-16481-4 Full text in Research Archive.
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Full text in Research Archive.
• Aas, Monica; Henry, C.; Bellivier, F; Lajnef, M; Gard, S; Kahn, J-P; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Bjella, Thomas; Leboyer, M; Andreassen, Ole Andreas; Melle, Ingrid & Etain, B (2017). Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  47(5), s 902- 912 . doi: 10.1017/S0033291716003081
• Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine.  ISSN 0033-2917.  47(4), s 669- 679 . doi: 10.1017/S0033291716002762
• Aas, Monica; Melle, Ingrid; Bettella, Francesco; Djurovic, Srdjan; Le Hellard, Stephanie; Bjella, Thomas; Ringen, Petter Andreas; Lagerberg, Trine Vik; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Andreassen, Ole Andreas & Tesli, Martin Steen (2017). Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. Psychological Medicine.  ISSN 0033-2917.  48(1), s 43- 49 . doi: 10.1017/S0033291717001209 Full text in Research Archive.
• Andreassen, Ole Andreas (2017). eHealth provides a novel opportunity to exploit the advantages of the Nordic countries in psychiatric genetic research, building on the public health care system, biobanks, and registries.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  ISSN 1552-4841.  177(7), s 625- 629 . doi: 10.1002/ajmg.b.32561
• Athanasiu, Lavinia; Giddaluru, Sudheer; Neto, Carla Patricia Duarte Fernande; Christoforou, Andrea; Reinvang, Ivar; Lundervold, Astri; Nilsson, Lars-Göran; Kauppi, Karolina; Adolfsson, Rolf; Eriksson, Elias; Sundet, Kjetil Søren; Djurovic, Srdjan; Espeseth, Thomas; Nyberg, Lars Erik; Steen, Vidar Martin; Andreassen, Ole Andreas & Le Hellard, Stephanie (2017). A genetic association study of CSMD1 and CSMD2 with cognitive function. Brain, behavior, and immunity.  ISSN 0889-1591.  61, s 209- 216 . doi: 10.1016/j.bbi.2016.11.026
• Bauer, Michael; Glenn, T; Alda, M; Aleksandrovich, MA; Andreassen, Ole Andreas; Angelopoulos, E; Ardau, R; Ayhan, Y; Baethge, C; Bharathram, SR; Bauer, R; Baune, BT; Becerra-Palars, C; Bellivier, F; Belmaker, RH; Berk, M; Bersudsky, Y; Bicakci, Ş; Birabwa-Oketcho, H; Bjella, Thomas; Bossini, L; Cabrera, J; Cheung, EYW; Del Zompo, M; Dodd, S; Donix, M; Etain, B; Fagiolini, A; Fountoulakis, KN; Frye, MA; Gonzalez-Pinto, A; Gottlieb, JF; Grof, P; Harima, H; Henry, C; Isometsa, ET; Janno, S; Kapczinski, F; Kardell, M; Khaldi, S; Kliwicki, S; König, B; Kot, TL; Krogh, R; Kunz, M; Lafer, B; Landen, M; Larsen, ER; Lewitzka, U; Licht, RW; Lopez-Jaramillo, C; MacQueen, G; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Melle, Ingrid; Meza-Urzua, F; Yee Ming, M; Monteith, S; Morken, Gunnar; Mosca, E; Munoz, R; Mythri, SV; Nacef, F; Nadella, RK; Nery, FG; Nielsen, RE; O'Donovan, C; Omrani, A; Osher, Y; Østermark Sørensen, H; Ouali, U; Pica Ruiz, Y; Pilhatsch, M; Pinna, M; da Ponte, FDR; Quiroz, D; Ramesar, R; Rasgon, N; Reddy, MS; Reif, A; Ritter, P; Rybakowski, JK; Sagduyu, K; Scippa, ÂM; Severus, E; Simhandl, C; Stein, DJ; Strejilevich, S; Subramaniam, M; Sulaiman, AH; Suominen, K; Tagata, H; Tatebayashi, Y; Tondo, L; Torrent, C; Vaaler, Arne; Veeh, J; Vieta, E; Viswanath, B; Yoldi-Negrete, M; Zetin, M; Zgueb, Y & Whybrow, Peter C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(6), s 571- 582 . doi: 10.1111/acps.12772
• Berg, Akiah Ottesen; Melle, Ingrid; Zuber, Verena; Simonsen, Carmen Elisabeth; Nerhus, Mari; Ueland, Torill; Andreassen, Ole Andreas; Sundet, Kjetil Søren & Vaskinn, Anja (2017). Modelling difficulties in abstract thinking in psychosis: the importance of socio-developmental background. Cognitive Neuropsychiatry.  ISSN 1354-6805.  22(1), s 39- 52 . doi: 10.1080/13546805.2016.1259998
• Bjørke-Bertheussen, Janette; Schøyen, Helle Kristine; Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Ødegaard, Ketil Joachim; Morken, Gunnar; Sundet, Kjetil Søren; Vaaler, Arne; Auestad, Bjørn Henrik & Kessler, Ute (2017). Right unilateral electroconvulsive therapy does not cause more cognitive impairment than pharmacologic treatment in treatment-resistant bipolar depression: A 6-month randomized controlled trial follow-up study. Bipolar Disorders.  ISSN 1398-5647.  20(6), s 531- 538 . doi: 10.1111/bdi.12594
• Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Schork, Andrew; Fan, Chun-Chieh; Holland, Dominic; Kauppi, Karolina; Smeland, Olav Bjerkehagen; Djurovic, Srdjan; Sanyal, Nilotpal; Hibar, Derrek; Thompson, Paul M.; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2017). Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Scientific Reports.  ISSN 2045-2322.  7:15736, s 1- 9 . doi: 10.1038/s41598-017-15705-x
• Church, Chelsea; Andreassen, Ole Andreas; Lorentzen, Steinar; Melle, Ingrid & Aas, Monica (2017). Childhood trauma and minimization/denial in people with and without a severe mental disorder. Frontiers in Psychology.  ISSN 1664-1078.  8 . doi: 10.3389/fpsyg.2017.01276
• Còrdova Palomera, Aldo; Kaufmann, Tobias; Persson, Karin; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Lund, Martina Jonette; Barca, Maria Lage; Engvig, Andreas; Brækhus, Anne; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum. Scientific Reports.  ISSN 2045-2322.  7(40268), s 1- 14 . doi: 10.1038/srep40268 Full text in Research Archive. Show summary

  As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.

• Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Haatveit, Beathe Christin; Andreassen, Ole Andreas; Ueland, Torill & Ueland, Torill (2017). Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study. Psychiatry Research.  ISSN 0165-1781.  249, s 286- 292 . doi: 10.1016/j.psychres.2016.12.048
• Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J; Cabral, Howard J; Cupples, L. Adrienne; Thompson, Wesley Kurt; Besser, Lilah; Kukull, Walter A.; Holland, Dominic; Chen, Chi-Hua; Brewer, James B.; Karow, David S.; Kauppi, Karolina; Witoelar, Aree; Karch, Celeste M.; Bonham, Luke W.; Yokoyama, Jennifer S.; Rosen, Howard J.; Miller, Bruce L.; Dillon, William P.; Wilson, David M.; Hess, Christopher P.; Pericak-Vance, Margaret; Haines, Jonathan L.; Farrer, Lindsay A.; Mayeux, Richard; Hardy, John; Goate, Alison M.; Hyman, Bradley T.; Schellenberg, Gerard D.; McEvoy, Linda K.; Andreassen, Ole Andreas & Dale, Anders (2017). Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Nature Methods.  ISSN 1548-7091.  14(3:e1002258), s 1- 17 . doi: 10.1371/journal.pmed.1002258
• Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen; Fan, Chun Chieh; Schork, Andrew J.; Holland, Dominic; Thompson, Wesley Kurt; Witoelar, Aree; Chen, Chi-Hua; Desikan, Rahul S.; McEvoy, Linda K.; Djurovic, Srdjan; Greengard, Paul; Svenningsson, Per; Einevoll, Gaute & Dale, Anders (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry.  ISSN 1359-4184.  22(6), s 792- 801 . doi: 10.1038/mp.2017.33 Full text in Research Archive.
• Doan, Nhat Trung; Engvig, Andreas; Persson, Karin; Alnæs, Dag; Kaufmann, Tobias; Rokicki, Jaroslav; Còrdova Palomera, Aldo; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum. Scientific Reports.  ISSN 2045-2322.  7:45131 . doi: 10.1038/srep45131 Show summary

  Recent efforts using diffusion tensor imaging (DTI) have documented white matter (WM) alterations in Alzheimer’s disease (AD). The full potential of whole-brain DTI, however, has not been fully exploited as studies have focused on individual microstructural indices independently. In patients with AD (n = 79), mild (MCI, n = 55) and subjective (SCI, n = 30) cognitive impairment, we applied linked independent component analysis (LICA) to model inter-subject variability across five complementary DTI measures (fractional anisotropy (FA), axial/radial/mean diffusivity, diffusion tensor mode), two crossing fiber measures estimated using a multi-compartment crossing-fiber model reflecting the volume fraction of the dominant (f1) and non-dominant (f2) diffusion orientation, and finally, connectivity density obtained from full-brain probabilistic tractography. The LICA component explaining the largest data variance was highly sensitive to disease severity (AD < MCI < SCI) and revealed widespread coordinated decreases in FA and f1 with increases in all diffusivity measures in AD. Additionally, it reflected regional coordinated decreases and increases in f2, mode and connectivity density, implicating bidirectional alterations of crossing fibers in the fornix, uncinate fasciculi, corpus callosum and major sensorimotor pathways. LICA yielded improved diagnostic classification performance compared to univariate region-of-interest features. Our results document coordinated WM microstructural and connectivity alterations in line with disease severity across the AD continuum.

• Doan, Nhat Trung; Engvig, Andreas; Zaske, Krystal; Persson, Karin; Lund, Martina Jonette; Kaufmann, Tobias; Còrdova Palomera, Aldo; Alnæs, Dag; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Nordvik, Jan Egil; Engedal, Knut; Agartz, Ingrid; Selbæk, Geir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples. NeuroImage.  ISSN 1053-8119.  158, s 282- 295 . doi: 10.1016/j.neuroimage.2017.06.070 Full text in Research Archive.
• Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders. NeuroImage: Clinical.  ISSN 2213-1582.  15, s 719- 731 . doi: 10.1016/j.nicl.2017.06.014 Full text in Research Archive.
• Dørum, Erlend Solberg; Kaufmann, Tobias; Alnæs, Dag; Andreassen, Ole Andreas; Richard, Geneviéve´; Kolskår, Knut-Kristian; Nordvik, Jan Egil & Westlye, Lars Tjelta (2017). Increased sensitivity to age-related differences in brain functional connectivity during continuous multiple object tracking compared to resting-state. NeuroImage.  ISSN 1053-8119.  148, s 364- 372 . doi: 10.1016/j.neuroimage.2017.01.048
• Engelstad, Katharina Nymo; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Vaskinn, Anja (2017). Body language reading of emotion in schizophrenia: associations with symptoms and functional outcome. Scandinavian Journal of Psychology.  ISSN 0036-5564.  58(5), s 359- 366 . doi: 10.1111/sjop.12381
• Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witoelar, Aree; Karch, Celeste M.; Schork, Andrew J.; Fan, Chun C.; Brewer, James B.; Momeni, Parastoo; Schellenberg, Gerard D.; Dillon, William P.; Sugrue, Leo P.; Hess, Christopher P.; Yokoyama, Jennifer S.; Bonham, Luke W.; Rabinovici, Gil D.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Hardy, John & Desikan, Rahul S. (2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry.  ISSN 0022-3050.  88(2), s 152- 164 . doi: 10.1136/jnnp-2016-314411
• Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2017). 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(11), s 2398- 2405 . doi: 10.1111/bcp.13341
• Gupta, Cota Navin; Castro, Eduardo; Rachkonda, Srinivas; Van Erp, Theo G.M.; Potkin, Steven; Ford, Judith Marianne; Mathalon, Daniel H.; Lee, Hyo Jong; Mueller, Bryon A.; Greve, Douglas; Andreassen, Ole Andreas; Agartz, Ingrid; Mayer, Andrew Robert; Stephen, Julia; Jung, Rex E; Bustillo, Juan R; Calhoun, Vince D. & Turner, Jessica A. (2017). Biclustered independent component analysis for complex biomarker and subtype identification from structural magnetic resonance images in schizophrenia. Frontiers in Psychiatry.  ISSN 1664-0640.  8 . doi: 10.3389/fpsyt.2017.00179
• Gupta, Cota Navin; Van Erp, Theo G M; Rachkonda, Srinivas; Potkin, Steven; Andreassen, Ole Andreas; Agartz, Ingrid & Turner, Jessica A (2017). Biclustered Independent Component Analysis for Complex Biomarker and Subtype Identification from Structural Magnetic Resonance Images in Schizophrenia.. Frontiers in Psychiatry.  ISSN 1664-0640. . doi: 10.3389/fpsyt.2017.00179
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis. Journal of Neurophysiology.  ISSN 0022-3077.  118(1), s 114- 120 . doi: 10.1152/jn.00976.2016 Full text in Research Archive.
• Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Bratlien, Unni; Barnaby, Nelson; Melle, Ingrid & Møller, Paul (2017). High levels of anomalous self-experience are associated with longer duration of untreated psychosis. Early Intervention in Psychiatry.  ISSN 1751-7885.  11(2), s 133- 138 . doi: 10.1111/eip.12220 Full text in Research Archive.
• Hellstrøm, Torgeir; Kaufmann, Tobias; Andelic, Nada; Søberg, Helene L.; Sigurdardottir, Solrun; Helseth, Eirik; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Predicting outcome 12 months after mild traumatic brain injury in patients admitted to a neurosurgery service. Frontiers in Neurology.  ISSN 1664-2295.  8:125, s 1- 12 . doi: 10.3389/fneur.2017.00125 Full text in Research Archive.
• Hellstrøm, Torgeir; Westlye, Lars Tjelta; Kaufmann, Tobias; Doan, Nhat Trung; Søberg, Helene L.; Sigurdardottir, Solrun; Nordhøy, Wibeke; Helseth, Eirik; Andreassen, Ole Andreas & Andelic, Nada (2017). White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-13628-1 Full text in Research Archive.
• Hellstrøm, Torgeir; Westlye, Lars Tjelta; Sigurdardottir, Solrun; Brunborg, Cathrine; Søberg, Helene L.; Holthe, Øyvor; SERVER, ANDRES; Lund, Martina Jonette; Andreassen, Ole Andreas & Andelic, Nada (2017). Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables. Brain Injury.  ISSN 0269-9052.  31(5), s 674- 685 . doi: 10.1080/02699052.2017.1283537 Full text in Research Archive.
• Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteriá, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R.K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn Kristin H.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil Nordbø; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C.M.; Lopez, Lorna M.; Luciano, Michelle; MacAre, Christine; Marquand, André F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Sämann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van Der Grond, Jeroen; Van Der Lee, Sven J.; Van Der Meer, Dennis; van Donkelaar, Marjolein M.J.; Van Eijk, Kristel R.; Van Erp, Theo G.M.; Van Rooij, Daan; Walton, Esther; Westlye, Lars Tjelta; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole Andreas; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; Van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders; Davies, Gareth E.; de Craen, Anton J.M.; de Geus, Eco J.C.; De Jager, Philip L.; de Zubicaray, Greig I.; Deary, Ian J.; Debette, Stéphanie; Decarli, Charles; Delanty, Norman; Depondt, Chantal; Destefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernandéz, Guillén; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Göring, Harald H.H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R.; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik Gunnar; Jukema, J. Wouter; Kahn, René S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nöthen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W.J.H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar Martin; Stott, David J.; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, André G.; Hernández, Maria C. Valdés; Van Der Brug, Marcel; Van Der Lugt, Aad; Van Der Wee, Nic J.A.; van Haren, Neeltje E.M.; Van 'T Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; Van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, William T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M. & Ikram, M. Arfan (2017). Novel genetic loci associated with hippocampal volume. Nature Communications.  ISSN 2041-1723.  8:13624, s 1- 12 . doi: 10.1038/ncomms13624 Full text in Research Archive.
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Full text in Research Archive.
• Høyland, Anne Lise; Nærland, Terje; Engstrøm, Morten; Lydersen, Stian & Andreassen, Ole Andreas (2017). The relation between face-emotion recognition and social function in adolescents with autism spectrum disorders: A case control study. PLOS ONE.  ISSN 1932-6203.  12(10), s 1- 16 . doi: 10.1371/journal.pone.0186124 Full text in Research Archive.
• Høyland, Anne Lise; Øgrim, Kjell Geir; Lydersen, Stian; Hope, Sigrun; Engstrøm, Morten; Torske, Tonje; Nærland, Terje & Andreassen, Ole Andreas (2017). Event-related potentials in a cued Go-NoGo task associated with executive functions in adolescents with autism spectrum disorder; A case-control study. Frontiers in Neuroscience.  ISSN 1662-4548.  11:393, s 1- 13 . doi: 10.3389/fnins.2017.00393 Full text in Research Archive.
• Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample. International Journal of Molecular Sciences.  ISSN 1422-0067.  18(5), s 1- 14 . doi: 10.3390/ijms18051078 Full text in Research Archive.
• Jørgensen, Kjetil Nordbø; Nesvåg, Ragnar; Nerland, Stener; Mørch-Johnsen, Lynn; Westlye, Lars Tjelta; Lange, Elisabeth; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  135(2), s 117- 126 . doi: 10.1111/acps.12677
• Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Doan, Nhat Trung; Kauppi, Karolina; Bettella, Francesco; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Djurovic, Srdjan; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets. NeuroImage.  ISSN 1053-8119.  147, s 243- 252 . doi: 10.1016/j.neuroimage.2016.11.073
• Kaufmann, Tobias; Alnæs, Dag; Doan, Nhat Trung; Brandt, Christine Lycke; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Delayed stabilization and individualization in connectome development are related to psychiatric disorders. Nature Neuroscience.  ISSN 1097-6256.  20(4), s 513- 515 . doi: 10.1038/nn.4511
• Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Pedersen, Geir Feigum; Bellivier, Frank; Icick, Romain; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2017). Alcohol use disorders are Associated With increased effective lability in bipolar disorder. Journal of Affective Disorders.  ISSN 0165-0327.  208, s 316- 324 . doi: 10.1016/j.jad.2016.09.062
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe D; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2017). Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets. Cell reports.  ISSN 2211-1247.  21(9), s 2597- 2613 . doi: 10.1016/j.celrep.2017.11.028
• Lange, Elisabeth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn; Nesvåg, Ragnar; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Osnes, Kåre; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls. Psychological Medicine.  ISSN 0033-2917.  47(4), s 655- 668 . doi: 10.1017/S0033291716002920
• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco; Hugdahl, Kenneth; Espeseth, Thomas; Steen, Vidar Martin; Melle, Ingrid; Desikan, Rahul S.; Schork, Andrew J.; Thompson, Wesley Kurt; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin.  ISSN 0586-7614.  43(3), s 654- 664 . doi: 10.1093/schbul/sbw085
• Li, Dong; Chang, Xiao; Connolly, John J.; Tian, Lifeng; Liu, Yichuan; Bhoj, Elizabeth J.; Robinson, Nora; Abrams, Debra; Li, Yun R.; Bradfield, Jonathan P.; Kim, Cecilia E.; Li, Jin; Wang, Fengxiang; Snyder, James; Lemma, Maria; Hou, Cuiping; Wei, Zhi; Guo, Yiran; Qiu, Haijun; Mentch, Frank D.; Thomas, Kelly A.; Chiavacci, Rosetta M.; Cone, Roger; Li, Bingshan; Sleiman, Patrick A.; Hakonarson, Hakon; Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Espeseth, Thomas; Huckins, Laura M; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie; Mattingsdal, Morten; Tozzi, Federica; Kiezebrink, Kirsty; Hebebrand, Johannes; Gorwood, Philip; Adan, Roger A H; Kas, Martien J H; Favaro, Angela; Santonastaso, Paolo; Fernande-Aranda, Fernando; Gratacos, Monica; Rybakowski, Filip; Dmitrzak-Weglarz, Monika; Kaprio, Jaakko; Keski-Rahkonen, Anna; Raevuori-Helkamaa, Anu; Furth, Eric F Van; Slof-Opt Landt, Margarita C T; Hudson, James I; Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy S; Monteleone, Palmiero; Karwautz, Andreas; Berrettini, Wade H; Schork, Nicholas J; Ando, Tetsuya; Inoko, Hidetoshi; Esko, Tonu; Fischer, Krista; Mannik, Katrin; Metspalu, Andres; Baker, Jessica H; DeSocio, Janiece E; Hilliard, Christopher E; O'Toole, Julie K; Pantel, Jacques; Szatkiewicz, Jin P; Zerwas, Stephanie; Davis, Oliver S P; Helder, Sietske; Buhren, Katharina; Burghardt, Roland; De Zwaan, Martina; Egberts, Karin; Ehrlich, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Imgart, Hartmut; Scherag, Andre; Zipfel, Stephan; Boni, Claudette; Ramoz, Nicolas; Versini, Audrey; Danner, Unna N; Hendriks, Judith; Koeleman, Bobby P C; Ophoff, Roel A; Strengman, Eric; Van Elburg, Annemarie A; Bruson, Alice; Clementi, Maurizio; Degortes, Daniela; Forzan, Monica; Tenconi, Elena; Docampo, Elisa; Escaramis, Georgia; Jimenez-Murcia, Susana; Lissowska, Jolanta; Rajewski, Andrzej; Szeszenia-Dabrowska, Neonila; Slopien, Agnieszka; Hauser, Joanna; Karhunen, Leila; Meulenbelt, Ingrid; Slagboom, P Eline; Tortorella, Alfonso; Maj, Mario; Dedoussis, George; DIkeos, DImitris; Gonidakis, Fragiskos; Tziouvas, Konstantinos; Tsitsika, Artemis; Papezova, Hana; Slachtova, Lenka; Martaskova, Debora; Kennedy, James L; Levitan, Robert D; Yilmaz, Zeynep; Huemer, Julia; Koubek, Doris; Merl, Elisabeth; Wagner, Gudrun; Lichtenstein, Paul; Breen, Gerome; Cohen-Woods, Sarah; Farmer, Anne; McGuffin, Peter; Cichon, Sven; Giegling, Ina; Herms, Stefan; Rujescu, Dan; Schreiber, Stefan; Wichmann, H-Erich; DIna, Christian; Sladek, Rob; Gambaro, Giovanni; Soranzo, Nicole; Julia, Antonio; Marsal, Sara; Rabionet, Raquel; Gaborieau, Valerie; DIck, Danielle M; Palotie, Aarno; Ripatti, Samuli; Widen, Elisabeth; Andreassen, Ole A; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Steen, Vidar M; Le Hellard, Stephanie; Mattingsdal, Morten; Ntalla, Ioanna; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Navratilova, Marie; Gallinger, Steven; Pinto, Dalila; Scherer, Stephen W; Aschauer, Harald; Carlberg, Laura; Schosser, Alexandra; Alfredsson, Lars; DIng, Bo; Klareskog, Lars; Padyukov, Leonid; Finan, Chris; Kalsi, Gursharan; Roberts, Marion; Barrett, Jeff C; Estivill, Xavier; Hinney, Anke; Sullivan, Patrick F; Zeggini, Eleftheria; Bulik, Cynthia M; Brandt, Harry; Crawford, Steve; Crow, Scott; Fichter, Manfred M; Halmi, Katherine A; Johnson, Craig; Kaplan, Allan S; La Via, Maria C; Mitchell, James; Strober, Michael; Rotondo, Alessandro; Treasure, Janet; Woodside, D Blake; Keel, Pamela K; Klump, Kelly L; Lilenfeld, Lisa; Bergen, Andrew W; Kaye, Walter & Magistretti, Pierre (2017). A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling. Scientific Reports.  ISSN 2045-2322.  7:3847, s 1- 9 . doi: 10.1038/s41598-017-01674-8
• Lo, Min-Tzu; Wang, Yunpeng; Kauppi, Karolina; Sanyal, Nilotpal; Fan, Chun-Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew; Holland, Dominic; Hinds, David A; Tung, Joyce Y; Andreassen, Ole Andreas; Dale, Anders M & Chen, Chi-Hua (2017). Modeling prior information of common genetic variants improves gene discovery for neuroticism. Human Molecular Genetics.  ISSN 0964-6906.  26(22), s 4530- 4539 . doi: 10.1093/hmg/ddx340
• Lu, Y; Pouget, Jennie G.; Andreassen, Ole Andreas; Djurovic, Srdjan; Esko, Tönu; Hultman, Christina M; Metspalu, Andres; Milani, Lili; Werge, Thomas & Sullivan, Patrick F (2017). Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. Psychological Medicine.  ISSN 0033-2917.  48(7), s 1201- 1208 . doi: 10.1017/S0033291717002665
• Mäki-Marttunen, Tuomo; Lines, Glenn Terje; Edwards, Andrew G; Tveito, Aslak; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational Psychiatry.  ISSN 2158-3188.  7(5) . doi: 10.1038/s41398-017-0007-4 Full text in Research Archive.
• Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fuentes Fajarado, Karin V.; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot; Alexander, Madeline; Amin, Farooq; Atkins, Joshua; Bacanu, Silviu A.; Belliveau, Richard A.; Bergen, Sarah E.; Bertalan, Marcelo; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Bulik-Sullivan, Brendan; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Cheng, Wei; Cloninger, C. Robert; Cohen, David; Cormican, Paul; Craddock, Nick; Crespo-Facorro, Benedicto; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; DeLisi, Lynn E.; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farh, Kai-How; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedman, Joseph I.; Forstner, Andreas J.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Gershon, Elliot S.; Giegling, Ina; Giusti-Rodriguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Gratten, Jacob; De Haan, Lieuwe; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Huang, Hailiang; Ikeda, Masashi; Joa, Inge; Kähler, Anna Katarina; Kahn, René S.; Kalaydjieva, Luba; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kelly, Brian J.; Kennedy, James L.; Kim, Yunjung; Knowles, James A.; Konte, Bettina; Laurent, Claudine; Lee, Phil; Lee, S. Hong; Legge, Sophie E.; Lerer, Bernard; Levy, Deborah L.; Liang, Kung-Yee; Lieberman, Jeffrey; Lonnqvist, Jouko; Loughland, Carmel M.; Magnusson, Patrik K.E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Muller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; O'Neill, F. Anthony; Van Os, Jim; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Perkins, Diana O.; Pers, Tune H.; Pietilainen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Savitz, Adam; Schall, Ulrich; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Silverman, Jeremy M.; Smoller, Jordan W.; Söderman, Erik; Spencer, Chris CA; Stahl, Eli A.; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Thirumalai, Srinivas; Tooney, Paul A.; Veijola, Juha; Visscher, Peter M.; Waddington, John; Walsh, Dermot; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wormley, Brandon K.; Wray, Naomi R.; Wu, Jing Qin; Zai, Clement C.; Adolfsson, Rolf; Andreassen, Ole Andreas; Blackwood, Douglas H.R.; Bramon, Elvira; Buxbaum, Joseph D.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Daly, Mark J.; Darvasi, Ariel; Domenici, Enrico; Esko, Tonu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik Gunnar; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Levinson, Douglas F.; Li, Qingqin S.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sklar, Pamela; St. Clair, David; Walters, James T.R.; Werge, Thomas; Sullivan, Patrick F.; O'Donovan, Michael C.; Scherer, Stephen W.; Neale, Benjamin M. & Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics.  ISSN 1061-4036.  49, s 27- 35 . doi: 10.1038/ng.3725
• McLaughlin, Russell L.; Schijven, Dick; Van Rheenen, Wouter; Van Eijk, Kristel R.; O'Brien, Margaret; Kahn, René S.; Ophoff, Roel A.; Goris, An; Bradley, Daniel G.; Al-Chalabi, Ammar; van den Berg, Leonard H.; Luykx, Jurjen J.; Hardiman, Orla; Veldink, Jan H.; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid & Andreassen, Ole Andreas (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications.  ISSN 2041-1723.  8:14774, s 1- 12 . doi: 10.1038/ncomms14774
• Mellerup, Erling; Andreassen, Ole Andreas; Bennike, Bente; Dam, H; Djurovic, Srdjan; Jorgensen, Martin Balslev; Kessing, Lars Vedel; Koefoed, Pernille; Melle, Ingrid; Mors, Ole & Moeller, GL (2017). Combinations of genetic variants associated with bipolar disorder.. PLOS ONE.  ISSN 1932-6203.  12(12) . doi: 10.1371/journal.pone.0189739
• Moberget, Torgeir; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Lagerberg, Trine Vik; Diedrichsen, Jörn; Schwarz, E.; Zink, M; Eisenacher, S.; Kirsch, Peter; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Pergola, G; Quarto, T; Bertolino, A; Barch, D; Meyer-Lindenberg, Andreas; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls. Molecular Psychiatry.  ISSN 1359-4184.  23(6), s 1512- 1520 . doi: 10.1038/mp.2017.106
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(4), s 400- 408 . doi: 10.1111/acps.12783
• Nerhus, Mari; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Haram, Marit; Haatveit, Beathe Christin; Dahl, Sandra Rinne; Gurholt, Tiril Pedersen; Bjella, Thomas; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Vitamin D deficiency associated with cognitive functioning in psychotic disorders. Journal of Clinical Psychiatry.  ISSN 0160-6689.  78(7), s e750- e757 . doi: 10.4088/JCP.16m10880
• Nesvåg, Ragnar; Jönsson, Erik Gunnar; Bakken, Inger Johanne; Knudsen, Gun Peggy; Bjella, Thomas; Reichborn-Kjennerud, Ted; Melle, Ingrid & Andreassen, Ole Andreas (2017). The quality of severe mental disorder diagnoses in a national health registry as compared to research diagnoses based on structured interview. BMC Psychiatry.  ISSN 1471-244X.  17(1) . doi: 10.1186/s12888-017-1256-8 Full text in Research Archive.
• Olafsson, Sigurgeir; Olafsson, S.; Stridh, Pernilla; Stridh, P.; Bos, Steffan Daniel; Ingason, Andrés; Ingason, Andres; Euesden, J; Euesden, Jack; Sulem, Patrick; Thorleifsson, Gudmar; Gustafsson, O; Gustafsson, Omar; Geirsson, AJ; Jóhannesson, Ari J.; Geirsson, Arni J.; Thorsson, AV; Thorsson, Arni V.; Ludviksson, BR; Sigurgeirsson, Bardur; Olafsson, Elias; Jonasson, JG; Kristjansdottir, Helga; Olafsson, E; Jonasson, Jon G.; Kristjansdottir, H; Olafsson, JH; Ólafsson, Jón Hjaltalín; Orvar, KB; Benediktsson, Rafn; Bjarnason, Ragnar; Kristjansdottir, Sjofn; Gislason, Thorarin; Gislason, Thorarinn; Valdimarsson, T; Mikaelsdottir, E; Sigurdsson, S; Sigurdsson, Snaevar; Jonsson, S; Jonsson, Stefan; Rafnar, Thorunn; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Knudsen, Gun Peggy S.; Celius, Elisabeth Gulowsen; Myhr, Kjell-Morten; Gröndal, Gerdur; Steinsson, K; Steinsson, Kristjan; Valdimarsson, Helgi; Bjornsson, Sigurdur; Bjornsdottir, US; Bjornsdottir, Unnur S.; Bjornsson, Einar S.; Nilsson, Björn; Nilsson, B; Andreassen, Ole Andreas; Alfredsson, Lars; Hillert, Jan; Kockum, Ingrid; Másson, Gísli; Masson, Gisli; Thorsteinssdottir, U; Stefánsson, Kári; Gudbjartsson, Daniel F.; Stefansson, H; Hjaltason, H; Harbo, Hanne Flinstad; Olsson, T; Jonsdottir, I & Stefansson, K (2017). Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ GENOMIC MEDICINE.  ISSN 2056-7944.  2 . doi: 10.1038/s41525-017-0027-2 Full text in Research Archive. Show summary

  A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (P = 1.6 x 10(-7), 4.3 x 10(-9)) we used primary biliary cirrhosis as a proxy-phenotype for multiple sclerosis, the idea being that variants conferring risk of primary biliary cirrhosis have a prior probability of conferring risk of multiple sclerosis. We tested 255 variants forming the primary biliary cirrhosis-polygenic risk score and found seven multiple sclerosis-associating variants not correlated with any previously established multiple sclerosis variants. Most of the variants discovered are close to or within immune-related genes. One is a low-frequency missense variant in TYK2, another is a missense variant in MTHFR that reduces the function of the encoded enzyme affecting methionine metabolism, reported to be dysregulated in multiple sclerosis brain.

• Polushina, Tatiana; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri; Djurovic, Srdjan; Cichon, Sven; Hoffmann, P; Nöthen, Markus M; Steen, Vidar Martin; Andreassen, Ole Andreas & Le Hellard, Stephanie (2017). Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data. Translational Psychiatry.  ISSN 2158-3188.  7(12) . doi: 10.1038/s41398-017-0033-2
• Quintana, Daniel; Dieset, Ingrid; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2017). Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in Neuroendocrinology (FIN).  ISSN 0091-3022.  45, s 1- 10 . doi: 10.1016/j.yfrne.2016.12.004 Full text in Research Archive.
• Quintana, Daniel; Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik Fredrik; Groote, Inge Rasmus; Kaufmann, Tobias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Diurnal Variation and twenty-four hour sleep deprivation do not alter supine heart rate variability in healthy male young adults. PLOS ONE.  ISSN 1932-6203.  12:e0170921(2), s 1- 16 . doi: 10.1371/journal.pone.0170921 Full text in Research Archive.
• Quintana, Daniel; Westlye, Lars Tjelta; Hope, Sigrun; Nærland, Terje; Elvsåshagen, Torbjørn; Dørum, Erlend Solberg; Rustan, Øyvind; Valstad, Mathias; Rezvaya, Liudmila; Lishaugen, Hanna; Stensønes, Elise; Yaqub, Sheraz; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2017). Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial. Translational Psychiatry.  ISSN 2158-3188.  e1136(7), s 1- 9 . doi: 10.1038/tp.2017.103 Full text in Research Archive.
• Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng & Andreassen, Ole Andreas (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry.  ISSN 0890-8567.  57(2), s 86- 95 . doi: 10.1016/j.jaac.2017.11.013 Full text in Research Archive.
• Simonsen, Carmen Elisabeth; Færden, Ann; Romm, Kristin Lie; Berg, Akiah Ottesen; Bjella, Thomas; Sundet, Kjetil Søren; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up. Psychiatry Research.  ISSN 0165-1781.  254, s 118- 125 . doi: 10.1016/j.psychres.2017.04.050
• Skåtun, Kristina Cecilie; Kaufmann, Tobias; Brandt, Christine Lycke; Doan, Nhat Trung; Alnæs, Dag; Tønnesen, Siren; Biele, Guido; Vaskinn, Anja; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder. Brain Imaging and Behavior.  ISSN 1931-7557. . doi: 10.1007/s11682-017-9714-y
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen; Wang, Yunpeng; Krull, Florian; Bettella, Francesco; Eriksen, Jon Alm; Witoelar, Aree; Davies, Gail; Fan, Chun Chieh; Thompson, Wesley Kurt; Lam, Max; Lencz, Todd; Chen, Chi-Hua; Ueland, Torill; Jönsson, Erik Gunnar; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry.  ISSN 2168-6238.  74(10), s 1065- 1075 . doi: 10.1001/jamapsychiatry.2017.1986 Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin.  ISSN 0586-7614.  44(4), s 854- 864 . doi: 10.1093/schbul/sbx148
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr; Witoelar, Aree; Tesli, Martin Steen; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports.  ISSN 2045-2322.  7:2222(1), s 1- 9 . doi: 10.1038/s41598-017-02346-3 Full text in Research Archive.
• Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa; Spigset, Olav & Molden, Espen (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs.  ISSN 1172-7047.  31(11), s 991- 997 . doi: 10.1007/s40263-017-0469-1
• Srinivasan, Saurabh; Bettella, Francesco; Hassani, Sahar; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Collier, David A.; Desikan, Rahul S.; Melle, Ingrid; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Probing the association between early evolutionary markers and schizophrenia. PLOS ONE.  ISSN 1932-6203.  12:e0169227(1), s 1- 15 . doi: 10.1371/journal.pone.0169227
• Styrkarsdóttir, Unnur; Helgason, Hannes; Sigurdsson, Asgeir; Norddahl, Gudmundur L.; Agustsdottir, Arna B.; Reynard, Louise N.; Villalvilla, Amanda; Halldorsson, Gisli H.; Jonasdóttir, Aslaug; Magnúsdóttir, Auður; Oddson, Asmundur; Sulem, Gerald; Zink, Florian; Sveinbjornsson, Gardar; Helgason, Agnar; Jóhannsdóttir, Hrefna S.; Helgadottir, Anna; Stefansson, Hreinn; Grétarsdóttir, Sólveig; Rafnar, Thorunn; Almdahl, Ina; Brækhus, Anne; Fladby, Tormod; Selbæk, Geir; Hosseinpanah, Farhad; Azizi, Fereidoun; Koh, Jung Min; Tang, Nelson L.S.; Daneshpour, Maryam S.; Mayordomo, Jose Ignacio; Welt, Corrine; Braund, Peter S.; Samani, Nilesh J.; Kiemeney, Lambertus A.; Lohmander, L. Stefan; Christiansen, Claus; Andreassen, Ole Andreas; Magnusson, Olafur; Masson, Gisli; Kong, Augustine; Jonsdóttir, Ingileif; Gudbjartsson, Daniel; Sulem, Patrick; Jonsson, Helgi; Loughlin, John; Ingvarsson, Thorvaldur; Thorsteinsdóttir, Unnur & Stefansson, Kari (2017). Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics.  ISSN 1061-4036.  49(5), s 801- 805 . doi: 10.1038/ng.3816
• Sullivan, Patrick F; Agrawal, Arpana; Bulik, Cynthia M.; Andreassen, Ole Andreas; Borglum, Anders D; Breeb, Gerome; Cichon, Sven; Edenberg, Howard J; Faraone, Stephen V.; Gelernter, Joel; Mathews, Carol A; Nievergelt, Caroline M. & Smoller, Jordan W (2017). Psychiatric Genomics: An Update and an Agenda. American Journal of Psychiatry.  ISSN 0002-953X.  175(1), s 15- 27 . doi: 10.1176/appi.ajp.2017.17030283
• Tan, Chin Hong; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P.; Broce, Iris J.; Hess, Christopher P.; Dillon, William P.; Bonham, Luke W.; Yokoyama, Jennifer S.; Karch, Celeste M.; Brewer, James B.; Rabinovici, Gil D.; Miller, Bruce L.; Schellenberg, Gerard D.; Kauppi, Karolina; Feldman, Howard A.; Holland, Dominic; McEvoy, Linda K.; Hyman, Bradley T.; Bennett, David A.; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2017). Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica.  ISSN 0001-6322.  135(1), s 85- 93 . doi: 10.1007/s00401-017-1789-4
• Tan, Chin Hong; Hyman, Bradley T.; Tan, Jacinth J.X.; Hess, Christopher P.; Dillon, William P.; Schellenberg, Gerard D.; Besser, Lilah M.; Kukull, Walter A.; Kauppi, Karolina; McEvoy, Linda K.; Andreassen, Ole Andreas; Dale, Anders; Fan, Chun Chieh & Desikan, Rahul S. (2017). Polygenic hazard scores in preclinical Alzheimer disease. Annals of Neurology.  ISSN 0364-5134.  82(3), s 484- 488 . doi: 10.1002/ana.25029
• Trampush, Joey W.; Yang, M.L.Z.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.M.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan Gunnar; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William E.R.; Horan, Michael Arthur; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert Martin; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edyth; Poldrack, Russell Alan; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary J.; Morris, Derek W.; Corvin, Aiden; Gill, Michael; Hariri, Ahmad; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian John; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2017). GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium. Molecular Psychiatry.  ISSN 1359-4184.  22(3), s 336- 345 . doi: 10.1038/mp.2016.244 Full text in Research Archive.
• Valstad, Mathias; Alvares, Gail A.; Egknud, Maiken; Matziorinis, Anna Maria; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2017). The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews.  ISSN 0149-7634.  78, s 117- 124 . doi: 10.1016/j.neubiorev.2017.04.017 Full text in Research Archive.
• Vaskinn, Anja; Lagerberg, Trine Vik; Bjella, Thomas; Simonsen, Carmen Elisabeth; Andreassen, Ole Andreas; Ueland, Torill & Sundet, Kjetil Søren (2017). Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity. International journal of bipolar disorders.  ISSN 2194-7511.  5(13), s 1- 9 . doi: 10.1186/s40345-017-0083-7 Full text in Research Archive.
• Walton, Esther Fintan; Hibar, Derrek; Van Erp, Theo G.M.; Potkin, Steven G.; Roiz-Santiáñez, Roberto; Crespo-Facorro, Benedicto; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S.; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Preda, Adrian; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Ciullo, Valentina; Spalletta, Gianfranco; Gur, Raquel E.; Gur, Ruben C.; Wolf, Daniel H.; Satterthwaite, Theaodore D.; Beard, Lauren M.; Sommer, Iris E.; Koops, Sanne; Gruber, Oliver; Richter, Anja; Krämer, B.; Kelly, Sinéad; Donohoe, Gary J.; McDonald, Colm; Cannon, Dara M.; Corvin, Aiden; Gill, Michael; Di Giorgio, Annabella; Bertolino, Alessandro; Lawrie, Stephen M.; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, Jessica A. & Ehrlich, Stefan (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  135(5), s 439- 447 . doi: 10.1111/acps.12718
• Winsvold, Bendik K S; Bettella, Francesco; Witoelar, Aree; Anttila, Verneri; Gormley, Padhraig; Kurth, Tobias; Terwindt, Gisela M; Freilinger, Tobias; Frei, Oleksandr; Shadrin, Alexey A.; Wang, Yunpeng; Dale, Anders; Van Den Maagdenberg, Arn M.J.M.; Chasman, Daniel I; Nyholt, Dale R; Palotie, Aarno; Andreassen, Ole Andreas & Zwart, John-Anker (2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE.  ISSN 1932-6203.  s 1- 15 . doi: 10.1371/journal.pone.0185663 Full text in Research Archive.
• Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael; Thompson, Wesley Kurt; Hernandez, Dena G.; Djurovic, Srdjan; Schork, Andrew J.; Bettella, Francesco; Ellinghaus, David; Franke, Andre; Lie, Benedicte Alexandra; McEvoy, Linda K.; Karlsen, Tom Hemming; Lesage, Suzanne; Morris, Huw R.; Brice, Alexis; Wood, Nicholas W.; Heutink, Peter; Hardy, John; Singleton, Andrew B.; Dale, Anders; Gasser, Thomas; Andreassen, Ole Andreas & Sharma, Manu (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology.  ISSN 2168-6149.  74(7), s 780- 792 . doi: 10.1001/jamaneurol.2017.0469
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• Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi; Ross, Owen A.; Rademakers, Rosa; Kim, Jungsu; Wang, Yunpeng; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Momeni, Parastoo; Sugrue, Leo P.; Hess, Christopher P.; Barkovich, A. James; Boxer, Adam L.; Seeley, William W.; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Schmansky, Nicholas J.; Fischl, Bruce; Hyman, Bradley T.; Dickson, Dennis W.; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders; Desikan, Rahul S. & Desikan, Rahul S (2017). Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica.  ISSN 0001-6322.  133(5), s 825- 837 . doi: 10.1007/s00401-017-1693-y
• Zuber, Verena; Bettella, Francesco; Witoelar, Aree; Andreassen, Ole Andreas; Mills, Ian Geoffrey & Urbanucci, Alfonso (2017). Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. BMC Genomics.  ISSN 1471-2164.  18:270, s 1- 11 . doi: 10.1186/s12864-017-3620-y Full text in Research Archive.
• Uhlirova, Hana; Kiliç, Kivilcim; Tian, Peifang; Thunemann, Martin; Desjardins, Michèle; Saisan, Payam A.; Sakadžić, Sava; Ness, Torbjørn Vefferstad; Mateo, Celine; Cheng, Qun; Weldy, Kimberly L.; Razoux, Florence; Vandenberghe, Matthieu; Cremonesi, Jonathan A.; Ferri, Christopher G.L.; Nizar, Krystal; Sridhar, Vishnu B.; Steed, Tyler C.; Abashin, Maxim; Fainman, Yeshaiahu; Masliah, Eliezer; Djurovic, Srdjan; Andreassen, Ole Andreas; Silva, Gabriel A.; Boas, David A.; Kleinfeld, David; Buxton, Richard B.; Einevoll, Gaute; Dale, Anders & Devor, Anna (2016). Cell type specificity of neurovascular coupling in cerebral cortex. eLIFE.  ISSN 2050-084X.  5:e14315(2016) . doi: 10.7554/eLife.14315 Full text in Research Archive.
• Aas, Monica; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Færden, Ann; Romm, Kristin Lie; Nesvåg, Ragnar; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Agartz, Ingrid & Melle, Ingrid (2016). A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. BMC Psychiatry.  ISSN 1471-244X.  16 . doi: 10.1186/s12888-016-0827-4 Full text in Research Archive.
• Aas, Monica; Henry, Chantal; Andreassen, Ole Andreas; Bellivier, Frank; Melle, Ingrid & Etain, Bruno (2016). The role of childhood trauma in bipolar disorders. International journal of bipolar disorders.  ISSN 2194-7511.  4(2) . doi: 10.1186/s40345-015-0042-0
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• Bigdeli, Tim B.; Ripke, Stephan; Bacanu, Silviu-Alin; Lee, Sang Hong; Wray, Naomi R.; Gejman, Pablo V.; Rietschel, Marcella; Cichon, Sven; St Clair, David; Corvin, Aiden; Kirov, George K.; McQuillin, Andrew; Gurling, Hugh; Rujescu, Dan; Andreassen, Ole Andreas; Werge, Thomas; Blackwood, Douglas H.R.; Pato, Carlos N.; Pato, Michele T.; Malhotra, Anil K.; O'Donovan, Michael C.; Kendler, Kenneth S. & Fanous, Ayman H. (2016). Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  ISSN 1552-4841.  171(2), s 276- 289 . doi: 10.1002/ajmg.b.32402
• Bonham, Luke W.; Geier, Ethan G.; Fan, Chun C.; Leong, Josiah K.; Besser, Lilah; Kukull, Walter A.; Kornak, John; Andreassen, Ole Andreas; Schellenberg, Gerard D.; Rosen, Howard J.; Dillon, William P.; Hess, Christopher P.; Miller, Bruce L.; Dale, Anders Martin; Desikan, Rahul S. & Yokoyama, Jennifer S. (2016). Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease. Annals of clinical and translational neurology.  ISSN 2328-9503.  3(9), s 668- 677 . doi: 10.1002/acn3.333

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• Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Malt, Eva Albertsen & Melle, Ingrid (2020). Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S.  ISBN 978-82-05-52662-4.  519 s.
• Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Malt, Eva Albertsen; Melle, Ingrid & Aarsland, Dag (red.) (2018). Lærebok i psykiatri. Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  1060 s.

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• Andreou, Dimitrios; Jørgensen, Kjetil Nordbø; Bakke, Laura A Wortinger; Engen, Kristine; Vaskinn, Anja; Ueland, Torill; Yolken, Robert H.; Andreassen, Ole Andreas & Agartz, Ingrid (2021). Cytomegalovirus infection and IQ in patients with severe mental illness and healthy individuals. Psychiatry Research.  ISSN 0165-1781. . doi: 10.1016/j.psychres.2021.113929 Show summary

  Cytomegalovirus (CMV) infection in immunocompetent adults is usually asymptomatic, but results in lifelong latency. Infection occurring congenitally or in immunodeficiency can lead to cognitive impairment. We aimed to investigate the associations between CMV exposure and intelligence quotient (IQ) in patients with schizophrenia spectrum disorders (SZS), bipolar spectrum disorders (BDS) and healthy controls (HC). CMV immunoglobulin G antibody concentrations were measured by immunoassay and expressed as dichotomous measures (seropositive/CMV+ vs. seronegative/CMV-). Based on a significant CMV-by-diagnosis-by-sex interaction on IQ, we investigated main and interaction effects of CMV and sex on IQ in each diagnostic category. Significant CMV-by-sex interactions were found in patient groups. In SZS, CMV+ female patients (n = 50) had significantly lower IQ than CMV- female patients (n = 33), whereas CMV+ (n = 48) and CMV- (n = 45) male patients did not differ in IQ. In BDS, CMV+ (n = 49) and CMV- (n = 37) female patients did not differ in IQ, whereas CMV+ male patients (n = 33) had significantly higher IQ than CMV- male patients (n = 32). Among HC, CMV+ (n = 138) and CMV- (n = 118) male participants as well as CMV+ (n = 125) and CMV- (n = 93) female participants did not differ in IQ. Our findings suggest that CMV exposure may affect IQ in patients with severe mental illness but not HC.

• Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Lennox, Ziada Ayorech; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted & Havdahl, Alexandra (2020). Early manifestations of genetic risk for neurodevelopmental disorders.
• Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth; Lennox, Ziada Ayorech; Magnus, Per; Njølstad, Pål Rasmus; Øyen, Anne-Siri; Stoltenberg, Camilla; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted & Havdahl, Alexandra (2020). Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders.
• Johnsen, Erik; Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Årsland, Dag & Malt, Eva Albertsen (2020). Psykofarmakologisk behandling av psykiske lidelser, I:  Lærebok i psykiatri Basisversjon.  Gyldendal Norsk Forlag A/S.  ISBN 978-82-05-52662-4.  Kapittel 21.  s 467 - 502
• Lennox, Ziada Ayorech; Davies, Neil; Hannigan, Laurie John; Askeland, Ragna Bugge; Tesli, Martin Steen; Andreassen, Ole Andreas; Reichborn-Kjennerud, Ted; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Ask, Helga; Davey Smith, George; Bulik, Cynthia & Havdahl, Alexandra (2020). Which Metabo-Psychiatric Factors Affect the Risk of Anorexia Nervosa? A Mendelian Randomization Study.
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato; Lagerberg, Trine Vik; Friestad, Christine; Andreassen, Ole Andreas; Melle, Ingrid & Haukvik, Unn Kristin H. (2020). Is early debut of substance use Associated With violent offending in schizophrenia?.
• Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato; Lagerberg, Trine Vik; Friestad, Christine; Andreassen, Ole Andreas; Melle, Ingrid & Haukvik, Unn Kristin H. (2020). Is early debut of substance use Associated With violent offending in schizophrenia?. Schizophrenia Bulletin.  ISSN 0586-7614.  46, s S24 . doi: https://doi.org/10.1093/schbul/sbaa028.055
• Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth; Andreassen, Ole Andreas; Davey-Smith, George; Reichborn-Kjennerud, Ted & Havdahl, Alexandra (2019). Early manifestations of genetic risk for neurodevelopmental disorders.
• Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Agartz, Ingrid (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
• Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking in Children with Suspected or Diagnosed Autism Spectrum Disorder.
• Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Tidlig motorikk og sammenheng med grad av autismesymptomer blant norske barn utredet for mistenkt autismespekterforstyrrelse (ASF).
• Tesli, Martin Steen; Corfield, Elizabeth; Zayats, Tetyana; Ask, Helga; Askeland, Ragna Bugge; Hannigan, Laurie; Robinson, Elise; Andreassen, Ole Andreas; Havdahl, Alexandra & Reichborn-Kjennerud, Ted (2019). Investigation of shared genetic risk between cardiometabolic morbidity and ADHD in a Norwegian family cohort using polygenic transmission disequilibrium test.
• Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Bjella, Thomas; Aas, Monica; Djurovic, Srdjan; Bellivier, Frank; Andreassen, Ole Andreas & Melle, Ingrid (2018). Affective lability and polygenic risk in bipolar disorder.
• Andreassen, Ole Andreas; Malt, Eva Albertsen; Elvsåshagen, Torbjørn; Steen, Vidar Martin & Aarsland, Dag (2018). Molekylærgenetikk og nevrologi, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.),  Lærebok i psykiatri.  Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  Kapittel 4.  s 85 - 118
• Andreassen, Ole Andreas; Malt, Eva Albertsen; Malt, Ulrik Fredrik; Aarsland, Dag & Melle, Ingrid (2018). Biopsykososial forståelsesmodell, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.),  Lærebok i psykiatri.  Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  Kapittel 6.  s 135 - 142
• Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  84(7), s 1624- 1625 . doi: 10.1111/bcp.13606
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research.  ISSN 0920-9964.  199, s 433- 435 . doi: 10.1016/j.schres.2018.03.011
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics.  ISSN 1832-4274.  21(5), s 394- 397 . doi: 10.1017/thg.2018.46
• Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Johnsen, Erik; Aarsland, Dag & Malt, Eva Albertsen (2018). Psykofarmakologisk behandling av psykiske lidelser, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.),  Lærebok i psykiatri.  Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  Kapittel 30.  s 897 - 976
• Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence.
• Smoller, Jordan W.; Andreassen, Ole Andreas; Edenberg, Howard J.; Faraone, Stephen V.; Glatt, Stephen J. & Kendler, Kenneth S. (2018). Correction to: Psychiatric genetics and the structure of psychopathology. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 1 . doi: 10.1038/s41380-018-0026-4
• Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research.  ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012
• Andreassen, Ole Andreas (2017). Diabetes and Schizophrenia-New Findings for an Old Puzzle.. American Journal of Psychiatry.  ISSN 0002-953X.  174(7), s 616- 617 . doi: 10.1176/appi.ajp.2017.17040409
• Andreassen, Ole Andreas (2017). Increasing support for association between immune system and severe mental illness - need to find the underlying mechanisms. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  135(2), s 95- 96 . doi: 10.1111/acps.12692
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Jørgensen, Kjetil Nordbø; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2017). Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder.
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute T. (2017). Extracellular diffusion can introduce errors in current source density estimates..
• Halnes, Geir; Solbrå, Andreas Våvang; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas; Malthe-Sørensen, Anders & Einevoll, Gaute T. (2017). Modelling electrical and chemical dynamics in brain tissue.
• Impellizzeri, Agata Antonina Rita; Szabo, Attila; Fjerdingstad, Hege Brincker; Sullivan, Gareth; Glover, Joel; Andreassen, Ole Andreas & Djurovic, Srdjan (2017). Using Stem Cells to Understand the Underlying Mechanisms of Polygenic Risk of Severe Mental Disorders.
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y; Franz, C; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, A.; Holland, D.; Kauppi, Karolina; Sanyal, Nilotpal; Escott-Price, Valentina; Smith, DJ; O'Donovan, Michael C; Stefansson, H; Bjornsdottir, Gyda; Thorgeirsson, TE; Stefansson, K; McEvoy, LK; Dale, AM; Andreassen, Ole Andreas & Chen, CH (2017). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.. Nature Genetics.  ISSN 1061-4036.  49(1), s 152- 156 . doi: 10.1038/ng.3736
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Layer V pyramidal cells as mediators of delta oscillations: Insights from biophysically detailed modeling and connections with schizophrenia genetics..
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Delta oscillations in schizophrenia: Insights from biophysically detailed modeling of networks of layer V pyramidal cells..
• Nerland, Stener; Antosz, Anna; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn Egeland; Andreassen, Ole Andreas & Agartz, Ingrid (2017). A Manual for Classifying Anatomical Variation of Heschl's Gyrus.
• Quintana, Daniel; Steen, Nils Eiel & Andreassen, Ole Andreas (2017). The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant. JAMA psychiatry.  ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2017.3738
• Røssberg, Jan Ivar; Andreassen, Ole Andreas & Ilner, Stein E. Opjordsmoen (2017). Medisinfrie sykehusposter – et kunnskapsløst tiltak. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(6), s 426- 427 . doi: 10.4045/tidsskr.17.0091
• Røssberg, Jan Ivar; Andreassen, Ole Andreas & Ilner, Stein E. Opjordsmoen (2017). Re: Psykiatriens indre konflikter eksponert. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(9), s 594- 595 . doi: 10.4045/tidsskr.17.0288
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin; Li, Wen; Florian, Krull; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A.; Li, Wen; Krull, Florian; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
• Thunemann, Martin; Ness, Torbjørn V; Kılıç, Kıvılcım; Desjardins, Michèle; Bompierre, Ségolène; Vandenberghe, Matthieu; Cheng, Qun; Weldy, Kimberly A.; Djurovic, Srdjan; Andreassen, Ole Andreas; Boas, David A.; Herzog, Herbert; Einevoll, Gaute; Dale, Anders M & Devor, Anna (2017). ACTIVATION OF CORTICAL NPY-EXPRESSING INTERNEURONS PRODUCES VASCULAR EFFECTS WITHOUT MEASURABLE LFP.
• Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag; Moberget, Torgeir; Kaufmann, Tobias; Sønderby, Ida Elken; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.

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