Ole Andreassen

Professor - NORMENT part UiO
Image of Ole Andreassen
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Visiting address Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 Oslo
Postal address OUS, Postboks 4956 Nydalen 0424 Oslo

Photo: Kirsten Sjøwall

EDUCATION

MD 1993, PhD 1996 Univ. of Bergen
Post doc 1998-2000 Harvard Medical School
Specialist in psychiatry 2006, Oslo University Hospital
RESEARCH AREAS
Psychiatric genetics, brain imaging genetics, somatic health and immunological factors in severe mental disorders, clinical pharmacogenetics, prediction tools and precision medicine 

POSITIONS - Current: 

2013 -  Director Centre of Excellence NORMENT, Professor, University of Oslo
2006 -  Attending psychiatrist (20 %), Outpatient clinic, Oslo University Hospital
2020 -  Co-director KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo
Previous: 
2012-2018: Director KG Jebsen Centre for Psychosis Research
2011-2012: Visiting Professor, UCSD, USA
2005-2011: Professor in Psychiatry, University of Oslo; Attending Psychiatrist, Oslo University Hospital
2001-2005: Combined position Resident Psychiatry, Oslo University Hospital - Ullevål; Senior Scientist, University of Oslo
2000-2001: Resident Dept. of Psychiatry, Oslo University Hospital - Ullevål
1998-2000: Post Doc, Massachusetts General Hospital, Harvard Medical School, USA
1996-1998: Internship Dept. of Surgery, Internal Medicine, Family Medicine, Stavanger University Hospital, Norway
1993-1996: PhD Research Fellow, Dept. of Physiology, University of Bergen, Norway

HONORS AND AWARDS

2021 Dementia Research Prize, Norwegian Health Association 
2021 Award Best Scientific Publication, Oslo University Hospital
2020 University of Oslo's Research Prize
2019 Excellent Researcher Award, Oslo University Hospital
2018 Bergesen Foundation Prize
2018 Award Best Scientific Publication, Oslo University Hospital
2017 Award Best Scientific Publication, Oslo University Hospital
2016 Award Best Scientific Publication, Oslo University Hospital
2014 Elected member of Norwegian Academy of Science and Letters
2012 Award Best Scientific Publication, Oslo University Hospital
2011 Award The Overlege Dr. M.D. Johan Carl Unger Vetlesen Charitable Fund
2011 Fulbright Scholarship
2011 Award Best Scientific Publication, Oslo University Hospital
2005 Research Leadership Award, Ullevål University Hospital
2004 Outstanding Young Investigator Award (OYI), Research Council of Norway (RCN)
2002 Research Stipend, Odd Fellow Medical Sciences Research Fund
2002 Lundbeck stipend, Research Award
1998 Research Stipend, Odd Fellow Medical Sciences Research Fund
1995 Award for Young Researchers, Scand. College of NeuroPsychopharmacology (SCNP)

SCIENTIFIC EVALUATIONS AND REFEREE

Editorial Board: Schizophr Bull, Acta Psych Scand, W J Biol Psych, Eur J Pharmacol, Acta Neuropsychiatrica.

Ad hoc referee: New Engl J Med, Nat Genet, Nat Med, Nat Commun, Lancet, BMJ, PNAS, Mol Psychiatry, JCI, Am J Psychiatry, JAMA Psychiatry, Biol Psychiatry, Schizophr Bull, Transl Psych, Neuropsychopharmacology, J Clin Psychiatry, Schizophr Res, Prog Neurobiol, J Psych Res, Int J Neuropharm, Pharmacogenom J, Cereb Cortex, Neurobiol Dis, J Neurochem, J Psych Neurosci, J Affect Disord, Neuromolecular Med.

Grant review: Canadian Medical Research Council (RC), Neurological Foundation New Zealand, RC of Spain, AERES France, ANR France, Faroe Island RC, Irish RC, BBSRC, Austrian RC, Wellcome Trust, UPEC, MRC, EU ERA-NET, Dutch RC, Swiss RC, Swedish RC, Danish RC, German RC, Univ. Lyon, Univ. Copenhagen, Karolinska Inst., Oslo Univ. Hospital, West Norway Health Region, ERC Starting Grants, Northern Norway Health Region, Univ Montpellier HCERES.

Promotions: Univ. Copenhagen, Univ. Pittsburgh, Duke Univ., UCSD, Karolinska Inst., Univ. Bergen, Norwegian Univ. Science Technology, Univ. Helsinki, Univ Aarhus, South Africa RC, UCSF, UCL

PhD adjudication: Univ. Bergen 3, NTNU 3, Univ. Copenhagen 3, Univ. Gothenburg 1, Karolinska Inst. 1, Univ. Oslo 2. Lausanne Univ: 1, Univ Basel 1, Cardiff Univ 1, KCL 1.

RESEARCH LEADERSHIP, ADMIN. EXPERIENCE

- Director CoE NORMENT  (2013-).  SFF NORMENT
- Director KG Jebsen Centre Psychosis Research (2012-2018). 
- Co-Director Scandinavian Collaboration of Psychiatric Etiology (SCOPE, 2005-),
- Co-Director Bipolar Research and Innovation Network (BRAIN) (2005-).
- Member Coordination Group Psychiatric Genomics Consortium (PGC) & Schizophrenia (2008-) Working Group.
- Chair PGC Bipolar disorder Working Group
- Chair ENIGMA Bipolar disorder Working group (2011-)
- Member Steering Committee FP7 EU projects ENBREC (2008-12), PsychDPC (2011-), ImageMend (2013-), R-LiNK (2019-), coordinator H2020 CoMorMent (2020-24) and H2020 RealMent (2021-)
- Leader of the National Research Area in Psychosis (“NORSMI”, 2009-).
- Co-director Oslo Univ. Hospital MRI Core Facility (2007-). 
- Associate Investigator Centre for Molecular Medicine Norway, a Nordic EMBL Partnership for Molecular Medicine node (2011-).
-Member Research Board OUH (2011-15).

SUPERVISION

Ongoing: Head supervisor for 3 research fellows (PhD students), co-supervisor for 11 PhD students, supervisor for 14 post docs.
Completed: 37 PhD supervisions incl. 17 as co-supervisor. 1 Master degree, 4 MD PhD student degrees, 21 post docs.
 
SCIENTIFIC PRODUCTION 
Tags: psychiatry, genetics, biostatistics, precision medicine

Publications

Ten representative publications from the last 10 years, main author:

  1. Andreassen OA, Djurovic S, … Dale AM. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92(2):197-209. 
  2. Hibar DP, .. .. Andreassen OA. Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry. 2016 Feb 9  21 (12), 1710. 
  3. Lo MT, Hinds DA, ..Andreassen OA*, CH Chen*. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat Genet 2017;49:152-6. 
  4. Hibar DP,..Andreassen OA. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018;23(4):932-942. 
  5. Stahl EA, Breen G,… Andreassen OA*, Kelsoe J*, Sklar P*. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51(5):793-803. 
  6. Jansen IE, .. Andreassen OA*, Posthuma D*. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat Genet. 2019;51(3):404-413. 
  7. Frei O, Holland D,...Andreassen OA*, Dale AM*. Bivariate Causal Mixture Model Quantifies Polygenic Overlap Between Complex Traits Beyond Genetic Correlation. Nat Commun 2019;10:2417. 
  8. Smeland OB,....Andreassen OA. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry 2020;25(4):844-853 
  9. Bahrami S,  ……Andreassen OA. Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study. JAMA Psychiatry. 2020 77:1-11. 
  10. Mulins M, …Andreassen OA. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology, Nat Genet 2021 Jun;53(6):817-829.

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  • Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Malt, Eva Albertsen & Melle, Ingrid (2020). Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S. ISBN 978-82-05-52662-4. 519 p.

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  • Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram & Holland, Dominic [Show all 114 contributors for this article] (2022). Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease (Nature Genetics, (2021), 53, 9, (1276-1282), 10.1038/s41588-021-00921-z). Nature Genetics. ISSN 1061-4036. 54(7). doi: 10.1038/s41588-022-01126-8.
  • Askeland, Ragna Bugge; Hannigan, Laurie John; O'Connell, Kevin Sean; Corfield, Elizabeth Claire; Frei, Oleksandr & Thapar, Anita [Show all 11 contributors for this article] (2022). Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.
  • Eilertsen, Espen Moen; Gillespie Cheesman, Rosa Catherine; Ayorech, Ziada; Røysamb, Espen; Pingault, Jean-Baptiste & Njølstad, Pål Rasmus [Show all 11 contributors for this article] (2022). On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. 63(10), p. 1186–1195. doi: 10.1111/jcpp.13654.
  • Van Assche, Evelien; Schulte, Eva C.; Andreassen, Ole; Smeland, Olav Bjerkehagen & Luykx, Jurjen J. (2022). Editorial: Cross-disorder Genetics in Neuropsychiatry. Frontiers in Neuroscience. ISSN 1662-4548. 16. doi: 10.3389/fnins.2022.826300.
  • Barkhuizen, Wikus; Pingault, Jean-Baptiste; Wang, Biyao; Hannigan, Laurie John; Eilertsen, Espen Moen & Andreassen, Ole [Show all 14 contributors for this article] (2021). Direct and indirect genetic influences involved in the intergenerational transmission of risk for ADHD in the Norwegian Mother, Father and Child Cohort. Behavior Genetics. ISSN 0001-8244. 51(6), p. 692–691.
  • Ayorech, Ziada; Gillespie Cheesman, Rosa Catherine; Eilertsen, Espen Moen; Torvik, Fartein Ask; Andreassen, Ole & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Investigating Heterogeneity in Depression Using Multiple Polygenic Scores. European Neuropsychopharmacology. ISSN 0924-977X. 51, p. E161–E161.
  • Johannessen, Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Kaale, Anett & Wirgenes, Katrine Verena [Show all 10 contributors for this article] (2021). Correction to: Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health (European Journal of Human Genetics, (2021), 10.1038/s41431-021-00966-y). European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/s41431-021-01021-6.
  • Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey A.; Bahrami, Shahram & Holland, Dominic [Show all 114 contributors for this article] (2021). Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease (Nature Genetics, (2021), 53, 9, (1276-1282), 10.1038/s41588-021-00921-z). Nature Genetics. ISSN 1061-4036. doi: 10.1038/s41588-021-00977-x.
  • Hannigan, Laurie John; Corfield, Elizabeth; Biele, Guido; Tilling, Kate; McAdams, Tom A. & Badini, Isabella [Show all 19 contributors for this article] (2021). The genomic basis of participation in the Norwegian Mother, Father and Child Cohort Study.
  • Ayorech, Ziada; Gillespie Cheesman, Rosa Catherine; Eilertsen, Espen Moen; Torvik, Fartein Ask; Andreassen, Ole & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Investigating Heterogeneity in Depression Using Multiple Polygenic Scores.
  • Ayorech, Ziada; Davies, Neil; Wootton, Robyn; Watson, Hunna J; Hannigan, Laurie John & Askeland, Ragna Bugge [Show all 17 contributors for this article] (2021). Differential causal risk patterns in childhood eating behaviours compared to adulthood anorexia nervosa. A Mendelian randomization study.
  • Hughes, Amanda; Morris, Tim; Ayorech, Ziada; Tesli, Martin Steen; Ask, Helga & Askeland, Ragna Bugge [Show all 16 contributors for this article] (2021). The causal effect of BMI on neurodevelopment: a within family Mendelian randomization study using MoBa. International Journal of Epidemiology. ISSN 0300-5771. 50(Suppl 1). doi: 10.1093/ije/dyab168.296. Full text in Research Archive
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey; Devor, Anna & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2020). Author Correction: Understanding the genetic determinants of the brain with MOSTest (Nature Communications, (2020), 11, 1, (3512), 10.1038/s41467-020-17368-1). Nature Communications. ISSN 2041-1723. 11(1). doi: 10.1038/s41467-020-18628-w.
  • Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan & Polderman, Tinca J. C. [Show all 10 contributors for this article] (2020). Author Correction: A global overview of pleiotropy and genetic architecture in complex traits (Nature Genetics, (2019), 51, 9, (1339-1348), 10.1038/s41588-019-0481-0). Nature Genetics. ISSN 1061-4036. 52(3). doi: 10.1038/s41588-019-0571-z.
  • Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole [Show all 7 contributors for this article] (2020). Correction: Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits (Translational Psychiatry, (2020), 10, 1, (198), 10.1038/s41398-020-00888-1). Translational Psychiatry. ISSN 2158-3188. 10(1). doi: 10.1038/s41398-020-01061-4.
  • Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Show all 97 contributors for this article] (2020). Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7). Nature Neuroscience. ISSN 1097-6256. 23(2). doi: 10.1038/s41593-019-0553-6.
  • Lennox, Ziada Ayorech; Davies, Neil; Hannigan, Laurie John; Askeland, Ragna Bugge; Tesli, Martin Steen & Andreassen, Ole Andreas [Show all 14 contributors for this article] (2020). Which Metabo-Psychiatric Factors Affect the Risk of Anorexia Nervosa? A Mendelian Randomization Study.
  • Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato & Lagerberg, Trine Vik [Show all 10 contributors for this article] (2020). Is early debut of substance use Associated With violent offending in schizophrenia? Schizophrenia Bulletin. ISSN 0586-7614. 46. doi: 10.1093/schbul/sbaa028.055.
  • Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato & Lagerberg, Trine Vik [Show all 10 contributors for this article] (2020). Is early debut of substance use Associated With violent offending in schizophrenia?
  • Johnsen, Erik; Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Årsland, Dag & Malt, Eva Albertsen (2020). Psykofarmakologisk behandling av psykiske lidelser, Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S. ISSN 978-82-05-52662-4. p. 467–502.
  • Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing & Pardiñas, Antonio F. [Show all 360 contributors for this article] (2019). Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4). Nature Genetics. ISSN 1061-4036. 51(6). doi: 10.1038/s41588-019-0435-6.
  • Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel & Abé, Christoph [Show all 59 contributors for this article] (2019). Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals (Neuropsychopharmacology, (2019), 44, 13, (2285-2293), 10.1038/s41386-019-0485-6). Neuropsychopharmacology. ISSN 0893-133X. 44(13). doi: 10.1038/s41386-019-0521-6.
  • Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin & Savage, Jeanne [Show all 15 contributors for this article] (2019). Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence (Molecular Psychiatry, (2020), 25, 4, (844-853), 10.1038/s41380-018-0332-x). Molecular Psychiatry. ISSN 1359-4184. 25(4), p. 914–914. doi: 10.1038/s41380-019-0456-7.
  • Pardiñas, Antonio F.; Holmans, Peter A.; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Show all 144 contributors for this article] (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2). Nature Genetics. ISSN 1061-4036. 51(7). doi: 10.1038/s41588-019-0450-7.
  • Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Show all 222 contributors for this article] (2019). Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x). Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10160-w.
  • Rongve, Arvid; Witoelar, Aree Widya; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla & Clarimon, Jordi [Show all 40 contributors for this article] (2019). Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study (Scientific Reports, (2019), 9, 1, (7013), 10.1038/s41598-019-43458-2). Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-51827-0.
  • Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
  • Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
  • Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking in Children with Suspected or Diagnosed Autism Spectrum Disorder .
  • Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Tidlig motorikk og sammenheng med grad av autismesymptomer blant norske barn utredet for mistenkt autismespekterforstyrrelse (ASF).
  • Tesli, Martin Steen; Corfield, Elizabeth; Zayats, Tetyana; Ask, Helga; Askeland, Ragna Bugge & Hannigan, Laurie [Show all 10 contributors for this article] (2019). Investigation of shared genetic risk between cardiometabolic morbidity and ADHD in a Norwegian family cohort using polygenic transmission disequilibrium test.
  • Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth & Andreassen, Ole Andreas [Show all 9 contributors for this article] (2019). Early manifestations of genetic risk for neurodevelopmental disorders.
  • Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen & Lagerberg, Trine Vik [Show all 12 contributors for this article] (2018). Affective lability and polygenic risk in bipolar disorder.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Show all 11 contributors for this article] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
  • Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan & Melle, Ingrid [Show all 61 contributors for this article] (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. ISSN 1832-4274. 21(5), p. 394–397. doi: 10.1017/thg.2018.46.
  • Becher, Rune; Valen, Håkon; Vist, Gunn Elisabeth; Brinchmann, Bendik Christian; Holme, Jørn Andreas & Grimsrud, Tom Kristian [Show all 13 contributors for this article] (2022). Adverse health effects of electronic cigarette use: an umbrella review and toxicological evaluation . Norwegian Institute of Public Health Division of Infection Control and Environmental Health, Division for Health Services. ISSN 978-82-8406-296-9. Full text in Research Archive
  • Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen & Corfield, Elizabeth [Show all 12 contributors for this article] (2020). Early manifestations of genetic risk for neurodevelopmental disorders. PsyArXiv (Preprint artikkel).
  • Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth & Ayorech, Ziada [Show all 14 contributors for this article] (2020). Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders. PsyArXiv (Preprint artikkel).

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Published Apr. 13, 2011 2:54 PM - Last modified July 15, 2021 12:22 PM

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