Ole Andreassen

Professor - NORMENT part UiO

Norwegian version of this page

Email ole.andreassen@medisin.uio.no

Phone +47 22117843

Mobile phone +47 99038893 +4799038893

Username

Visiting address Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 OSLO

Postal address OUS, Postboks 4956 Nydalen 0424 OSLO

Other affiliations Psychosis Research Centre

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Photo: Kirsten Sjøwall

EDUCATION

MD 1993, PhD 1996 Univ. Bergen

Post doc 1998-2000 Harvard Medical School

Psychiatrist 2006

RESEARCH AREAS

Psychiatric genetics, brain imaging and genetics, somatic health and immunological factors in severe mental disorders, clinical pharmacology and pharmacogenetics

POSITIONS

1993 - 1996: PhD research fellow, Dept. of Physiology, University of Bergen.

1996 - 1998: Internship Surgery, Internal Medicine, Family Medicine, Stavanger Univ. Hospital

1998 - 2000: Post doc, Massachusetts General Hospital, Harvard Medical School.

2000 - 2001: Resident Dept. of Psychiatry, Ullevål, Oslo University Hospital, Oslo.

2001 - 2005: Combined position as Psychiatric Resident, same place and Senior Scientist UiO.

2005 - Professor Inst. of Psychiatry, UiO and Attending Psychiatrist, Oslo University Hospital

2011-12: Visiting professor UCSD, CA, USA

2012: Director KJ Jebsen Centre

2013: Director CoE NORMENT

HONORS AND AWARDS

1995- Scand. College of NeuroPsychopharm, ‘Award for Young Researcher’.

1998- Research Price: Odd Fellow Medical Sciences Fund.

2002- Lundbeck stipend.

2002- Research Price: Odd Fellow Medical Sciences Fund.

- Outstanding Young Investigator Award, Research Council of Norway.

2005- Award for Research Leadership, Ullevål University Hospital.

2011– Researcher of the Month South East Norway.

2011- Award Best Scientific Publication OUH.

2011- Fulbright Scholarship.

2012- Award Best Scientific Publication OUH.

2014- Elected members of Norwegian Academy of Science and Letters

2018- Bergesen Award

2019- Excellent Researcher Award, Oslo University Hospital

SCIENTIFIC EVALUATIONS AND REFEREE

- Editorial Board: Schizophr Bull, W J Biol Psychiat, Eur J Pharmacol, Front Neurosci, Acta Neuropsychiatrica.

- Ad hoc referee: New Eng J Med, Lancet, Nat Genetics, Nat Med, BMJ, Mol Psychiatry, Am J Psychiatry, JAMA Psychiatry, Biol Psychiatry, Schizophr Bull, Curr Biol, Neuropsychopharmacology, J Clin Psychiatry.

- PhD adjudication: 12.

- Grant review: Canadian Medical Research Council (RC), Neurological Foundation New Zealand, RC of Spain, AERES France, ANR France, Faroe Island RC, Irish RC, BBSRC, Austrian RC, Wellcome Trust, UPEC, MRC, EU ERA-NET, JPND, Dutch RC, Swiss RC, Swedish RC, Danish RC, Univ. Lyon, Univ. Copenhagen, Karolinska Inst. Univ Gothenburg, ERC review board.

RESEARCH LEADERSHIP, ADMIN. EXPERIENCE

- Director CoE NORMENT (2013-). http://www.med.uio.no/norment/ -

- Director KG Jebsen Centre Psychosis Research (2012-2018).

- Co-Director Scandinavian Collaboration of Psychiatric Etiology (SCOPE, 2005-),

- Co-Director Bipolar Research and Innovation Network (BRAIN) (2005-).

- Member Coordination Group Psychiatric Genomics Consortium (PGC) Bipolar disorder. & Schizophrenia (2008-) Working Group.

- Chair ENIGMA Bipolar disorder Working group (2011-)

- Member Steering Committee FP7 EU projects ENBREC (2008-12), PsychDPC (2011-), ImageMend (2013-). R-LiNK (2019-), coordinator H2020 CoMorMent (2020-24)

- Leader of the National Research Area in Psychosis (“NORSMI”, 2009-).

- Co-director Oslo Univ. Hospital MRI Core Facility (2007-).

- Associate Investigator Centre for Molecular Medicine Norway, a Nordic EMBL Partnership for Molecular Medicine node (2011-).

-Member Research Board OUH (2011-15).

SUPERVISION

- Ongoing: Head supervisor for 5 research fellows (PhD students), co-supervisor for 5 PhD students, supervisor for 10 post docs.

– Completed: 30 PhD supervisions incl. 14 as co-supervisor. 1 Master degree, 4 MD PhD student degrees, 12 post docs.

SCIENTIFIC PRODUCTION

https://scholar.google.com/citations?hl=no&user=dilW0WsAAAAJ&view_op=list_works

https://www.ncbi.nlm.nih.gov/pubmed/?term=andreassen+oa

Tags: psychiatry, genetics, biostatistics

Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato; Jensen, Arvid; Hjell, Gabriela; Bell, Christina; Fischer-Vieler, Thomas; Tesli, Martin Steen; Andreassen, Ole Andreas; Melle, Ingrid; Agartz, Ingrid & Haukvik, Unn Kristin H. (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-020-01098-y
Aas, Monica; Bellivier, Frank; Bettella, Francesco; Henry, Chantal; Gard, Sebastien; Kahn, Jean-Pierre; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Melle, Ingrid; Leboyer, Marion; Jamain, Stéphane; Andreassen, Ole Andreas & Étain, Bruno (2019). Childhood maltreatment and polygenic risk in bipolar disorders. Bipolar Disorders. ISSN 1398-5647. s 1- 8 . doi: 10.1111/bdi.12851
Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational psychiatry. ISSN 2158-3188. 9 . doi: 10.1038/s41398-019-0432-7
Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill; Melle, Ingrid; Agartz, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research. ISSN 0920-9964. . doi: 10.1016/j.schres.2019.01.011
Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan & Hughes, Timothy (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology. ISSN 0893-133X. s 1- 9 . doi: 10.1038/s41386-019-0556-8
Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M.; Bertolino, Alessandro; Brandt, Christine Lycke; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik Gunnar; Kirsch, Peter; Lund, Martina Jonette; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry. ISSN 2168-6238. 76(7), s 739- 748 . doi: 10.1001/jamapsychiatry.2019.0257
Anderssen, Jannicke Fjæra; Simonsen, Carmen Elisabeth; Büchmann, Camilla Bakkalia; Barrett, Elizabeth Ann; Bjella, Thomas; Lagerberg, Trine Vik; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Melle, Ingrid & Aas, Monica (2019). Sleep disturbances in schizophrenia spectrum and bipolar disorders ? a transdiagnostic perspective. Comprehensive Psychiatry. ISSN 0010-440X. 91, s 6- 12 . doi: 10.1016/j.comppsych.2019.02.006
Bakke, Laura A. Wortinger; Engen, Kristine; Barth, Claudia; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Andreassen, Ole Andreas; Haukvik, Unn Kristin H.; Vaskinn, Anja; Ueland, Torill & Agartz, Ingrid (2019). Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants. Psychological Medicine. ISSN 0033-2917. s 1- 9 . doi: 10.1017/S0033291719002046
Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias; Ardau, Raffaella; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Becerra-Palars, Claudia; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa-Oketcho, Harriet; Bjella, Thomas; Cabrera, Jorge; Wo Cheung, Eric Y.; Del Zompo, Maria; Dodd, Seetal; Donix, Markus; Etain, Bruno; Fagiolini, Andrea; Fountoulakis, Kostas N.; Frye, Mark A.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Harima, Hirohiko; Henry, Chantal; Isometsä, Erkki T.; Janno, Sven; Kapczinski, Flávio; Kardell, Mathias; Khaldi, Slim; Kliwicki, Sebastian; Konig, Barbara; Kot, Timur L.; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Landén, Mikael; Larsen, Erik R.; Lewitzka, Ute; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Meza-Urzua, Fatima; Ming, Mok Yee; Monteith, Scott; Morken, Gunnar; Mosca, Enrica; Mozzhegorov, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nery, Fabiano G.; Nielsen, René E.; O'Donovan, Claire; Omrani, Adel; Osher, Yamima; Sørensen, Helle Østermark; Ouali, Uta; Ruiz, Yolanda Pica; Pilhatsch, Maximilian; Pinna, Marco; da Ponte, Francisco D.R.; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reddy, Mrinalini S.; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Raghuraman, Bharathram Sathur; Scippa, Ângela M.; Severus, Emanuel; Simhandl, Christian; Stackhouse, Paul W.; Stein, Dan J.; Strejilevich, Sergio; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Tondo, Leonardo; Torrent, Carla; Vaaler, Arne; Vares, Edgar; Veeh, Julia; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Zetin, Mark; Zgueb, Yosra & Whybrow, Peter C. (2019). Association between solar insolation and a history of suicide attempts in bipolar I disorder. Journal of Psychiatric Research. ISSN 0022-3956. 113, s 1- 9 . doi: 10.1016/j.jpsychires.2019.03.001
Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive & Selbæk, Geir (2019). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease. Translational psychiatry. ISSN 2158-3188. 9:273, s 1- 10 . doi: 10.1038/s41398-019-0592-5 Full text in Research Archive. Show summary
Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.
de Lange, Ann-Marie Glasø; Kaufmann, Tobias; van der Meer, Dennis; Maglanoc, Luigi Angelo; Alnæs, Dag; Moberget, Torgeir; Douaud, Gwenaëlle; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Population-based neuroimaging reveals traces of childbirth in the maternal brain. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), s 22341- 22346 . doi: 10.1073/pnas.1910666116
de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Aleman, André; Alpert, Kathryn I.; Bearden, Carrie E.; Bertolino, Alessandro; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E.L.; Cahn, Wiepke; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; de la Serna, Elena; di Giorgio, Annabella; Doucet, Gaëlle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Frankland, Andrew; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hillegers, Manon H.J.; Hulshoff Pol, Hilleke E.; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik Gunnar; Kane, Fergus; Kempton, Matthew J.; Koenis, Marinka M.G.; Kopecek, Miloslav; Krabbendam, Lydia; Krämer, Bernd; Lawrie, Stephen M.; Lenroot, Rhoshel K.; Marcelis, Machteld; Marsman, Jan-Bernard C.; Mattay, Venkata S.; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B.; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Özerdem, Ayşegül; Picchioni, Marco M.; Richter, Anja; Roberts, Gloria; Aydogan, Aybala Saricicek; Schofield, Peter R.; Simsek, Fatma; Soares, Jair C.; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Daniel R.; Whalley, Heather C.; Yalin, Nefize; Andreassen, Ole Andreas; Ching, Christopher R.K.; van Erp, Theo G.M.; Turner, Jessica A.; Jahanshad, Neda; Thompson, Paul M.; Kahn, René S. & van Haren, Neeltje E.M. (2019). The association between familial risk and brain abnormalities is disease specific: An ENIGMA-relatives study of schizophrenia and bipolar disorder. Biological Psychiatry. ISSN 0006-3223. 86(7), s 545- 556 . doi: 10.1016/j.biopsych.2019.03.985
Di Sero, Alessia; Jørgensen, Kjetil Nordbø; Nerland, Stener; Melle, Ingrid; Andreassen, Ole Andreas; Jovicich, Jorge & Agartz, Ingrid (2019). Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status. Schizophrenia Research. ISSN 0920-9964. 208, s 114- 123 . doi: 10.1016/j.schres.2019.04.002
Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary
Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.
Elman, Jeremy A.; Panizzon, Matthew S; Logue, Mark W.; Gillespie, Nathan A.; Neale, Michael C.; Reynolds, Chandra A.; Gustavson, Daniel E.; Rana, Brinda K; Andreassen, Ole Andreas; Dale, Anders M; Franz, Carol E; Lyons, Michael J & Kremen, William S (2019). Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiology of Aging. ISSN 0197-4580. . doi: 10.1016/j.neurobiolaging.2019.06.001
Engh, John; Egeland, Jens; Andreassen, Ole Andreas; Bang-Kittilsen, Gry; Bigseth, Therese Torgersen; Holmen, Tom Langerud; Martinsen, Egil Wilhelm; Mordal, Jon & Andersen, Eivind (2019). Objectively Assessed Daily Steps—Not Light Intensity Physical Activity, Moderate-to-Vigorous Physical Activity and Sedentary Time—Is Associated With Cardiorespiratory Fitness in Patients With Schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 10 . doi: 10.3389/fpsyt.2019.00082 Full text in Research Archive.
Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel; Abé, Christoph; Alda, Martin; Alloza, Clara; Alonso-Lana, Silvia; Andreassen, Ole Andreas; Baune, Bernhard T.; Benedetti, Francesco; Busatto, Geraldo F.; Canales-Rodríguez, Erick J.; Caseras, Xavier; Chaim-Avancini, Tiffany Moukbel; Ching, Christopher R.K.; Dannlowski, Udo; Deppe, Michael; Eyler, Lisa T.; Fatjo-Vilas, Mar; Foley, Sonya F.; Grotegerd, Dominik; Hajek, Tomas; Haukvik, Unn Kristin H.; Howells, Fleur M; Jahanshad, Neda; Kugel, Harald; Lagerberg, Trine Vik; Lawrie, Stephen M.; Linke, Julia O.; McIntosh, Andrew; Melloni, Elisa M.T.; Mitchell, Philip B.; Polosan, Mircea; Pomarol-Clotet, Edith; Repple, Jonathan; Roberts, Gloria; Roos, Annerine; Rosa, Pedro G.P.; Salvador, Raymond; Sarró, Salvador; Schofield, Peter R.; Serpa, Mauricio H; Sim, Kang; Stein, Dan J.; Sussmann, Jess E.; Temmingh, Henk S.; Thompson, Paul M.; Verdolini, Norma; Vieta, Eduard; Wessa, Michele; Whalley, Heather C.; Zanetti, Marcus V.; Leboyer, Marion; Mangin, Jean-François; Henry, Chantal; Duchesnay, Edouard & Houenou, Josselin (2019). Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology. ISSN 0893-133X. 44, s 2285- 2293 . doi: 10.1038/s41386-019-0485-6
Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Mæland, Steffen; O`Connell, Kevin; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications. ISSN 2041-1723. 10(1) . doi: 10.1038/s41467-019-10310-0
Frøyhaug, Mathias; Andersson, Stein; Andreassen, Ole Andreas; Ueland, Torill & Vaskinn, Anja (2019). Theory of mind in schizophrenia and bipolar disorder: psychometric properties of the Norwegian version of the Hinting Task. Cognitive Neuropsychiatry. ISSN 1354-6805. 24(6), s 454- 469 . doi: 10.1080/13546805.2019.1674645
Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin & Melle, Ingrid (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. s 1- 10 . doi: 10.1007/s00406-019-01017-w Full text in Research Archive.
Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(5), s 464- 471 . doi: 10.1111/acps.13019
Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole Andreas; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire; Dellenvall, Karin; Demontis, Ditte; De Rubeis, Silvia; Devlin, Bernie; Djurovic, Srdjan; Dumont, Ashley L.; Goldstein, Jacqueline I.; Hansen, Christine S.; Hauberg, Mads Engel; Hollegaard, Mads V.; Hope, Sigrun; Howrigan, Daniel P.; Huang, Hailiang; Hultman, Christina M.; Klei, Lambertus; Maller, Julian; Martin, Joanna; Martin, Alicia R.; Moran, Jennifer L.; Nyegaard, Mette; Nærland, Terje; Palmer, Duncan S.; Palotie, Aarno; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; dPoterba, Timothy; Poulsen, Jesper Buchhave; St. Pourcain, Beate; Qvist, Per; Rehnström, Karola; Reichenberg, Abraham; Reichert, Jennifer; Robinson, Elise B.; Roeder, Kathryn; Roussos, Panos; Saemundsen, Evald; Sandin, Sven; Satterstrom, F. Kyle; Smith, George Davey; Stefánsson, Hreinn; Steinberg, Stacy; Stevens, Christine R.; Sullivan, Patrick F.; Turley, Patrick; Walters, G. Bragi; Xu, Xinyi; Stefansson, Kari; Geschwind, Daniel H.; Nordentoft, Merete; Hougaard, David M.; Werge, Thomas; Mors, Ole; Mortensen, Preben Bo; Neale, Benjamin M.; Daly, Mark J. & Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics. ISSN 1061-4036. 51, s 431- 444 . doi: 10.1038/s41588-019-0344-8 Show summary
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping Genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared With other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD
Gudmundsson, Ólafur Ó.; Walters, Gudmundur Bragi; Ingason, Andrés; Johansson, Stefan; Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Gustafsson, Omar; Nawaz, Muhammad Sulaman; Jónsson, Gudbjörn F.; Jónsson, Lina; Knappskog, Per; Ingvarsdóttir, Ester; Davidsdóttir, Katrin; Djurovic, Srdjan; Knudsen, Gun Peggy Strømstad; Askeland, Ragna Bugge; Haraldsdóttir, Gyda S.; Baldursson, Gísli; Magnússon, Páll; Sigurdsson, Engilbert; Gudbjartsson, Daníel Fannar; Stéfansson, Hreinn; Andreassen, Ole Andreas; Haavik, Jan; Reichborn-Kjennerud, Ted & Stefánsson, Kári (2019). Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational psychiatry. ISSN 2158-3188. 9, s 1- 9 . doi: 10.1038/s41398-019-0599-y Full text in Research Archive.
Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Donohoe, Gary; Gill, M; Corvin, A & Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics. ISSN 0148-7299. . doi: 10.1002/ajmg.b.32716
Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan; Jönsson, Erik Gunnar; Melle, Ingrid; Holmans, P.; Faraone, Stephen V. & Glatt, Stephen J. (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-019-0463-8
Holmen, Tom Langerud; Egeland, Jens; Andersen, Eivind; Mordal, Jon; Andreassen, Ole Andreas; Ueland, Thor; Bigseth, Therese Torgersen; Bang-Kittilsen, Gry & Engh, John (2019). The association between cardiorespiratory fitness and cognition appears neither related to current physical activity nor mediated by brain-derived neurotrophic factor in a sample of outpatients with schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 10:785, s 1- 7 . doi: 10.3389/fpsyt.2019.00785 Full text in Research Archive. Show summary
Objective: We investigated whether levels of current physical activity (PA) contribute to the established relationship between cardiorespiratory fitness (CRF) and cognition in schizophrenia and whether brain-derived neurotrophic factor (BDNF) or its precursor proBDNF mediates this relationship. Method: Sixty-one outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale (WAIS) and nine subtests from the MATRICS battery comprising a neurocognitive composite score (NCS). CRF was assessed with peak oxygen uptake (VO2peak) measured directly during a maximum exercise test. Current PA levels were objectively assessed by an accelerometer worn for four consecutive days. BDNF and proBDNF were measured in fasting blood. Four serial parallel mediation analyses and two additional parallel mediation analyses were conducted, while controlling for age and sex at all levels. Results: No direct effects were found between PA measures and WAIS or NCS. No significant mediating effects of CRF or BDNF/proBDNF were detected. Conclusion: The results do not support the hypothesis that PA contributes to the naturally occurring relationship between CRF and cognition in schizophrenia or the hypothesis that BDNF or proBDNF mediates this relationship. The results arguably support the assumption that the association between CRF and cognition in schizophrenia is established developmentally early.
Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr; Nordvik, Jan Egil; Kolskår, Knut-Kristian; Richard, Geneviève; Andreassen, Ole Andreas; Harbo, Hanne Flinstad & Westlye, Lars Tjelta (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, s 1- 9 . doi: 10.3389/fneur.2019.00450
Høyland, Anne Lise; Nærland, Terje; Engstrøm, Morten; Torske, Tonje; Lydersen, Stian & Andreassen, Ole Andreas (2019). Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study. Molecular Autism. ISSN 2040-2392. 10(10) . doi: 10.1186/s13229-019-0259-3 Full text in Research Archive.
Icick, Romain; Melle, Ingrid; Étain, Bruno; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Leboyer, Marion.; Aas, Monica; Henry, Chantal; Bjella, Thomas; Andreassen, Ole Andreas; Bellivier, Frank & Lagerberg, Trine Vik (2019). Tobacco smoking and other substance use disorders associated with recurrent suicide attempts in bipolar disorder.. Journal of Affective Disorders. ISSN 0165-0327. 256, s 348- 357 . doi: 10.1016/j.jad.2019.05.075
Ing, Alex J.; Sämann, Philipp G.; Chu, Congying; Tay, Nicole; Biondo, Francesca; Robert, Gabriel; Jia, Tianye; Wolfers, Thomas; Desrivières, Sylvane; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Conrod, Patricia; Fadai, Tahmine; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip A.; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Ittermann, Bernd; Kappel, Viola; Martinot, Jean-Luc; Meyer-Lindenberg, Andreas; Millenet, Sabina; Nees, Frauke; van Noort, Betteke; Orfanos, Dimitri Papadopoulos; Martinot, Marie-Laure Paillère; Penttilä, Jani; Poustka, Luise; Quinlan, Erin Burke; Smolka, Michael N.; Stringaris, Argyris; Struve, Maren; Veer, Ilya M.; Walter, Henrik; Whelan, Robert; Andreassen, Ole Andreas; Agartz, Ingrid; Lemaître, Hervé; Barker, Edward D.; Ashburner, John; Binder, Elisabeth; Buitelaar, Jan; Marquand, André; Robbins, Trevor W. & Schumann, Gunter (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour. ISSN 2397-3374. 3(12), s 1306- 1318 . doi: 10.1038/s41562-019-0738-8
Iwaki, Hirotaka; Blauwendraat, Cornelis; Leonard, Hampton L.; Kim, Jonggeol J.; Liu, Ganqiang; Maple-Grødem, Jodi; Corvol, Jean-Christophe; Pihlstrøm, Lasse; van Nimwegen, Marlies; Hutten, Samantha J.; Nguyen, Khanh-Dung H.; Rick, Jacqueline; Eberly, Shirley; Faghri, Faraz; Auinger, Peggy; Scott, Kirsten M.; Wijeyekoon, Ruwani; Van Deerlin, Vivianna M.; Hernandez, Dena G.; Gibbs, J. Raphael; Chitrala, Kumaraswamy Naidu; Day-Williams, Aaron G.; Brice, Alexis; Alves, Guido Werner; Noyce, Alastair J.; Tysnes, Ole-Bjørn; Evans, Jonathan R.; Breen, David P.; Estrada, Karol; Wegel, Claire E.; Danjou, Fabrice; Simon, David K.; Andreassen, Ole Andreas; Ravina, Bernard; Toft, Mathias; Heutink, Peter; Bloem, Bastiaan R.; Weintraub, Daniel; Barker, Roger A.; Williams-Gray, Caroline H.; van de Warrenburg, Bart P.; van Hilten, Jacobus J.; Scherzer, Clemens R.; Singleton, Andrew B. & Nalls, Mike A. (2019). Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. Movement Disorders. ISSN 0885-3185. 34(12), s 1839- 1850 . doi: 10.1002/mds.27845
Izzo, Jessica; Andreassen, Ole Andreas; Westlye, Lars Tjelta & van der Meer, Dennis (2019). The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer’s disease. Brain Research. ISSN 0006-8993. s 1- 7 . doi: 10.1016/j.brainres.2019.146591
Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas & Posthuma, Danielle (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics. ISSN 1061-4036. 51(3), s 404- 413 . doi: 10.1038/s41588-018-0311-9 Full text in Research Archive.
Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta; Calhoun, Vince D. & Turner, Jessica A. (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder.. NeuroImage: Clinical. ISSN 2213-1582. s 1- 9 . doi: 10.1016/j.nicl.2019.101989
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7
Kremen, William S.; Panizzon, Matthew S.; Elman, Jeremy A.; Granholm, Eric L.; Andreassen, Ole Andreas; Dale, Anders; Gillespie, Nathan A.; Gustavson, Daniel E.; Logue, Mark W.; Lyons, Michael J.; Neale, Michael C.; Reynolds, Chandra A.; Whitsel, Nathan & Franz, Carol E. (2019). Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk. Neurobiology of Aging. ISSN 0197-4580. 83, s 114- 121 . doi: 10.1016/j.neurobiolaging.2019.09.001
Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2019). Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics. ISSN 0002-9297. 105(2), s 334- 350 . doi: 10.1016/j.ajhg.2019.06.012
Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020
Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Brain connectome mapping of complex human traits and their polygenic architecture using machine learning. Biological Psychiatry. ISSN 0006-3223. s 1- 10 . doi: 10.1016/j.biopsych.2019.10.011 Show summary
Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remains a challenge. Methods In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety and neuroticism using fMRI-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes, and 13 different neuroticism traits and schizophrenia. Results Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism and polygenic scores across traits. Conclusion These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with fMRI-based brain connectomics.
Mahmood, Javed Iqbal; Grotmol, Kjersti StÃ¸en; Tesli, Martin Steen; Moum, Torbjørn Åge; Andreassen, Ole Andreas & Tyssen, Reidar (2019). Life satisfaction in Norwegian medical doctors: a 15-year longitudinal study of work-related predictors. BMC Health Services Research. ISSN 1472-6963. 19:729, s 1- 10 . doi: 10.1186/s12913-019-4599-7
Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience. ISSN 1662-5188. 13 . doi: 10.3389/fncom.2019.00066 Full text in Research Archive.
Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan; Westlye, Lars Tjelta; Linne, Marja-Leena; Rietschel, Marcella; Schubert, Dirk; Borgwardt, Stefan; Efrim-Budisteanu, Magdalena; Bettella, Francesco; Halnes, Geir; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Edwards, Andrew G.; Metzner, Christoph; Fyhn, Marianne; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry. ISSN 1664-0640. 10 . doi: doi: 10.3389/fpsyt.2019.00534
Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), s 875- 891 . doi: 10.1093/cercor/bhy291
Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry. ISSN 0006-3223. 86(1), s 65- 75 . doi: 10.1016/j.biopsych.2019.01.019
Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew & Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry. ISSN 0002-953X. 176(8), s 651- 660 . doi: 10.1176/appi.ajp.2019.18080957
Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Andreassen, Ole Andreas; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Børglum, Anders D.; Werge, Thomas & Agerbo, Esben (2019). Association of polygenic liabilities for major depression, bipolar disorder, and schizophrenia with risk for depression in the Danish population. JAMA psychiatry. ISSN 2168-6238. 76(5), s 516- 525 . doi: 10.1001/jamapsychiatry.2018.4166
Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine. ISSN 0033-2917. 49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Show summary
Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role
Nalls, Mike A.; Blauwendraat, Cornelis; Vallerga, Costanza L.; Heilbron, Karl; Bandres-Ciga, Sara; Chang, Diana; Tan, Manuela; Kia, Demis A.; Noyce, Alastair J.; Xue, Angli; Bras, Jose; Young, Emily; von Coelln, Rainer; Simón-Sánchez, Javier; Schulte, Claudia; Sharma, Manu; Krohn, Lynne; Philstrøm, Lasse; Siitonen, Ari; Iwaki, Hirotaka; Leonard, Hampton; Faghri, Faraz; Gibbs, J. Raphael; Hernandez, Dena G.; Scholz, Sonja W.; Botía, Juan A.; Martinez, Maria; Corvol, Jean-Christophe; Lesage, Suzanne; Jankovic, Joseph; Shulman, Lisa M.; Sutherland, Margaret; Tienari, Pentti; Majamaa, Kari; Toft, Mathias; Andreassen, Ole Andreas; Bangale, Tushar; Brice, Alexis; Yang, Jian; Gan-Or, Ziv; Gasser, Thomas; Heutink, Peter; Shulman, Joshua M.; Wood, Nicholas W.; Hinds, David A.; Hardy, John A.; Morris, Huw R.; Gratten, Jacob; Visscher, Peter M.; Graham, Robert R. & Singleton, Andrew B. (2019). Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurology. ISSN 1474-4422. 18(12), s 1091- 1102 . doi: 10.1016/S1474-4422(19)30320-5
Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen; Choi, Karmel W.; Coleman, Jonathan R.I.; Dalvie, Shareefa; Duncan, Laramie E.; Gelernter, Joel; Levey, Daniel F.; Logue, Mark W.; Polimanti, Renato; Provost, Allison C.; Ratanatharathorn, Andrew; Stein, Murray B.; Torres, Katy; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Søren B.; Andreassen, Ole Andreas; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Børglum, Anders D.; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Dale, Anders; Daly, Mark J.; Daskalakis, Nikolaos P.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Dzubur-Kulenovic, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Geuze, Elbert; Gillespie, Charles; Uka, Afërdita Goçi; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljevíc, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Junglen, Angela G.; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin E.; Linnstaedt, Sarah D.; Lori, Adriana; Lugonja, Bozo; Luykx, Jurjen Justin; Lyons, Michael J.; Maples-Keller, Jessica; Marmar, Charles; Martin, Alicia R.; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; McLeay, Sarah; Mehta, Divya; Milberg, William P.; Miller, Mark W.; Morey, Rajendra A.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Neale, Benjamin M.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O'Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Ripke, Stephan; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Ken; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley Kurt; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Wolff, Jonathan D.; Yehuda, Rachel; Young, Ross McD.; Young, Keith A.; Zhao, Hongyu; Zoellner, Lori A.; Liberzon, Israel; Ressler, Kerry J.; Haas, Magali & Koenen, Karestan C. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications. ISSN 2041-1723. 10:4558, s 1- 16 . doi: 10.1038/s41467-019-12576-w
O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. s 1- 11 . doi: 10.1038/s41380-019-0613-z Show summary
Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, genetic correlation reported for these disorders is low and non-significant. Here we aimed to better characterize the genetic architecture of these disorders utilizing recent large genome-wide association studies (GWAS). We analyzed independent GWAS summary statistics for ADHD (19,099 cases and 34,194 controls) and BD (20,352 cases and 31,358 controls) applying the conditional/conjunctional false discovery rate (condFDR/conjFDR) statistical framework that increases the power to detect novel phenotype-specific and shared loci by leveraging the combined power of two GWAS. We observed cross-trait polygenic enrichment for ADHD conditioned on associations with BD, and vice versa. Leveraging this enrichment, we identified 19 novel ADHD risk loci and 40 novel BD risk loci at condFDR <0.05. Further, we identified five loci jointly associated with ADHD and BD (conjFDR < 0.05). Interestingly, these five loci show concordant directions of effect for ADHD and BD. These results highlight a shared underlying genetic risk for ADHD and BD which may help to explain the high comorbidity rates and difficulties in differentiating between ADHD and BD in the clinic. Improving our understanding of the underlying genetic architecture of these disorders may aid in the development of novel stratification tools to help reduce these diagnostic difficulties.
O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, G. Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan & Andreassen, Ole Andreas (2019). Identification of genetic loci shared between ADHD, intelligence and educational attainment. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2019.11.015
Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Dieset, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1) . doi: 10.1038/s41467-019-08503-8
Rahaman, MA; Turner, Jessica A.; Gupta, Cota Navin; Rachakonda, Srinivas; Chen, Jiayu; Liu, Jingyu; van Erp, Theo G.M.; Potkin, Steven; Ford, Judith; Mathalon, Daniel; Lee, Hyo Jong; Jiang, Wenhao; Mueller, Bryon A; Andreassen, Ole Andreas; Agartz, Ingrid; Sponheim, Scott R.; Mayer, Andrew Robert; Stephen, Julia; Jung, Rex E.; Canive, Jose; Bustillo, Juan R & Calhoun, Vince D. (2019). N-BiC: A Method for Multi-Component and Symptom Biclustering of Structural MRI Data: Application to Schizophrenia.. IEEE Transactions on Biomedical Engineering. ISSN 0018-9294. 67(1), s 110- 121 . doi: 10.1109/TBME.2019.2908815
Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. ISSN 0162-3257. s 1- 17 . doi: 10.1007/s10803-019-04112-y Full text in Research Archive.
Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J.; Holmans, Peter; Legge, Sophie E.; Savage, Jeanne E.; Agartz, Ingrid; Andreassen, Ole Andreas; Blokland, Gabriella A. M.; Corvin, Aiden; Cosgrove, Donna; Degenhardt, Franziska; Djurovic, Srdjan; Espeseth, Thomas; Ferraro, Laura; Gayer-Anderson, Charlotte; Giegling, Ina; van Haren, Neeltje E.M.; Hartmann, Annette M.; Hubert, John J.; Jönsson, Erik Gunnar; Konte, Bettina; Lennertz, Leonhard; Olde Loohuis, Loes M.; Melle, Ingrid; Morgan, Craig; Morris, Derek W.; Murray, Robin M.; Nyman, Håkan; Ophoff, Roel A.; van Os, Jim; Petryshen, Tracey L.; Quattrone, Diego; Rietschel, Marcella; Rujescu, Dan; Rutten, Bart P. F.; Streit, Fabian; Strohmaier, Jana; Sullivan, Patrick F.; Sundet, Kjetil Søren; Wagner, Michael; Escott-Price, Valentina; Owen, Michael J.; Donohoe, Gary; O'Donovan, Michael C. & Walters, James T R (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin. ISSN 0586-7614. . doi: 10.1093/schbul/sbz061 Show summary
BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.
Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10:649, s 1- 8 . doi: 10.3389/fpsyt.2019.00649
Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag & Andreassen, Ole Andreas (2019). GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific Reports. ISSN 2045-2322. 9 . doi: 10.1038/s41598-019-43458-2 Full text in Research Archive.
Rødevand, Linn; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna; Mørch, Ragni Helene; Lunding, Synve Hoffart; Vedal, Trude Seselie Jahr; Dieset, Ingrid; Melle, Ingrid; Lagerberg, Trine Vik & Andreassen, Ole Andreas (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(4), s 348- 360 . doi: 10.1111/acps.13008 Show summary
Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.
Sanyal, Nilotpal; Lo, Min-Tzu; Kauppi, Karolina; Djurovic, Srdjan; Andreassen, Ole Andreas; Johnson, Valen E. & Chen, Chi-Hua (2019). GWASinlps: Non-local prior based iterative SNP selection tool for genome-wide association studies. Bioinformatics. ISSN 1367-4803. 35(1), s 1- 11 . doi: 10.1093/bioinformatics/bty472
Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Show summary
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias; Wolfers, Thomas; Brecheisen, Ralph; Quarto, Tiziana; Ing, Alex J.; di Carlo, Pasquale; Gurholt, Tiril Pedersen; Harms, Robbert L.; Noirhomme, Quentin; Moberget, Torgeir; Agartz, Ingrid; Andreassen, Ole Andreas; Bellani, Marcella; Bertolino, Alessandro; Blasi, Giuseppe; Brambilla, Paolo; Buitelaar, Jan K.; Cervenka, Simon; Flyckt, Lena; Frangou, Sophia; Franke, Barbara; Hall, Jeremy; Heslenfeld, Dirk J.; Kirsch, Peter; McIntosh, Andrew M.; Nöthen, Markus M.; Papassotiropoulos, Andreas; de Quervain, Dominique J.F.; Rietschel, Marcella; Schumann, Gunter; Tost, Heike; Witt, Stephanie H.; Zink, Mathias & Meyer-Lindenberg, Andreas (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational psychiatry. ISSN 2158-3188. 9(12) . doi: 10.1038/s41398-018-0225-4
Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta & Bellivier, Frank (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. ISSN 2194-7511. 7(1), s 1- 10 . doi: 10.1186/s40345-019-0156-x
Simonsen, Carmen Elisabeth; Aminoff, Sofie Ragnhild; Vaskinn, Anja; Barrett, Elizabeth Ann; Færden, Ann; Ueland, Torill; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2019). Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 95:152134, s 1- 8 . doi: 10.1016/j.comppsych.2019.152134
Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2019). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Molecular Psychiatry. ISSN 1359-4184. s 1- 10 . doi: 10.1038/s41380-018-0332-x Full text in Research Archive.
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders & Andreassen, Ole Andreas (2019). The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges. Psychiatric Genetics. ISSN 0955-8829. 29(5), s 152- 159 . doi: 10.1097/YPG.0000000000000234 Show summary
Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a large number of common variants each with a small effect and many genetic variants influence more than one phenotype, suggesting shared genetic etiology. These concepts have the potential to revolutionize the current classification system with diagnostic categories and facilitate development of better treatments. However, to reach clinical impact, we need larger samples and better analytical tools, as most polygenic factors remain undetected. We here present statistical approaches designed to improve the yield of existing genome-wide association studies for polygenic phenotypes. We review how these tools have informed the current knowledge on the genetic architecture of psychiatric disorders, focusing on schizophrenia, bipolar disorder and major depression, and overlap with psychological and cognitive traits. We discuss application of statistical tools for stratification and prediction.
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O`Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders & Andreassen, Ole Andreas (2019). Discovery of shared genomic loci using the conditional false discovery rate approach. Human Genetics. ISSN 0340-6717. s 1- 10 . doi: 10.1007/s00439-019-02060-2 Full text in Research Archive.
Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), s 503- 508 . doi: 10.1097/FTD.0000000000000619
Solberg, Dag Kristen; Refsum, Helge; Andreassen, Ole Andreas & Bentsen, Håvard (2019). A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia. Acta Neuropsychiatrica. ISSN 0924-2708. 31(4), s 202- 212 . doi: 10.1017/neu.2019.14
Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John & Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. ISSN 1061-4036. 51(5), s 793- 803 . doi: 10.1038/s41588-019-0397-8 Full text in Research Archive.
Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2) . doi: 10.1017/S0033291719000400
Storvestre, Guttorm Breivik; Valnes, Lars Magnus; Jensen, Arvid; Nerland, Stener; Tesli, Natalia; Hymer, Knut-Erik; Røsæg, Cato; Server, Andres Alonso; Ringen, Petter Andreas; Jacobsen, Morten; Andreassen, Ole Andreas; Agartz, Ingrid; Melle, Ingrid & Haukvik, Unn Kristin H. (2019). A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 288, s 29- 36 . doi: 10.1016/j.pscychresns.2019.04.013
Tan, Chin Hong; Bonham, Luke W.; Fan, Chun Chieh; Mormino, Elizabeth C.; Sugrue, Leo P.; Broce, Iris J.; Hess, Christopher P.; Yokoyama, Jennifer S.; Rabinovici, Gil D.; Miller, Bruce L.; Yaffe, Kristine; Schellenberg, Gerard D.; Kauppi, Karolina; Holland, Dominic; McEvoy, Linda K.; Kukull, Walter A.; Tosun, Duygu; Weiner, Michael W.; Sperling, Reisa A.; Bennett, David A.; Hyman, Bradley T.; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2019). Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. ISSN 0006-8950. 142(2), s 460- 470 . doi: 10.1093/brain/awy327
Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
Torske, Tonje; Nærland, Terje; Bettella, Francesco; Bjella, Thomas; Malt, Eva Albertsen; Høyland, Anne Lise; Stenberg, Nina; Øie, Merete Glenne & Andreassen, Ole Andreas (2019). Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment. Autism Research. ISSN 1939-3792. . doi: 10.1002/aur.2207 Full text in Research Archive. Show summary
Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally deﬁned disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deﬁcit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5–22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a signiﬁcant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen’s d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, signiﬁcantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R2 = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a signiﬁcant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2019, 00: 1–14. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. Lay Summary: People with autism spectrum disorder (ASD) often have difﬁculties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difﬁculties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. Keywords: autism spectrum disorder; polygenic score; executive function; attention deﬁcit/hyperactivity disorder; behavior rating inventory of executive function
van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Cavalleri, Gianpiero L.; Ching, Christopher R.K.; Cichon, Sven; Ciufolini, Simone; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J.C.; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Delanty, Norman; den Braber, Anouk; Desrivieres, Sylvane; di Forti, Marta; Doherty, Joanne L.; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Håberg, Asta; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek; Hillegers, Manon H.J.; Hoffmann, Per; Holleran, Laurena; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jacquemont, Sébastien; Jahanshad, Neda; Jockwitz, Christiane; Johansson, Stefan; Jönsson, Erik Gunnar; Kikuchi, Masataka; Knowles, Emma E.M.; Kwok, John B.; Le Hellard, Stephanie; Linden, David E.J.; Liu, Jingyu; Lundervold, Arvid; Lundervold, Astri; Martin, Nicholas G.; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Moberget, Torgeir; Moreau, Clara; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nordvik, Jan Egil; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomáš; Pausova, Zdenka; Peralta, Juan M.; Pike, Bruce; Prieto, Carlos; Quinlan, Erin Burke; Reinbold, Céline Sonja; Reis Marques, Tiago; Rucker, James J.H.; Sachdev, Perminder S.; Sando, Sigrid Botne; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Steen, Vidar Martin; Stein, Dan J.; Strike, Lachlan T.; Tamnes, Christian Krog; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ülfarsson, Magnús Ö; van 't Ent, Dennis; van den Bree, Marianne B.M.; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Zayats, Tetyana; Dale, Anders; Djurovic, Srdjan; Agartz, Ingrid; Westlye, Lars Tjelta; Stefansson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2019.3779 Show summary
IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders
Vaskinn, Anja; Løvgren, André; Egeland, Maj Kristoffersen; Feyer, Frida Karine; Østefjells, Tiril; Andreassen, Ole Andreas; Melle, Ingrid & Sundet, Kjetil Søren (2019). A randomized controlled trial of training of affect recognition (TAR) in schizophrenia shows lasting effects for theory of mind. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(5), s 611- 620 . doi: 10.1007/s00406-019-00997-z
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001 Full text in Research Archive.
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Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; Mirkov, Maša Umićević; de Leeuw, Christiaan; Polderman, Tinca J.C.; van der Sluis, Sophie; Andreassen, Ole Andreas; Neale, Benjamin M. & Posthuma, Daniëlle (2019). A global overview of pleiotropy and genetic architecture in complex traits. Nature Genetics. ISSN 1061-4036. 51(9), s 1339- 1348 . doi: 10.1038/s41588-019-0481-0
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Broce, Iris J.; Tan, Chin Hong; Fan, CC; Jansen, Iris E.; Savage, Jeanne E.; Witoelar, Aree; Wen, Natalie; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Glymour, Maria; Yokoyama, Jennifer S.; Elahi, Fanny M; Rabinovici, Gil D.; Miller, Bruce L.; Mormino, Elizabeth C.; Sperling, Reisa A.; Bennett, David A; McEvoy, Linda K.; Brewer, James B.; Feldman, Howard; Hyman, Bradley T.; Pericak-Vance, Margaret; Haines, Jonathan L.; Farrer, Lindsay A.; Mayeux, Richard; Schellenberg, Gerard D.; Yaffe, Kristine; Sugrue, Leo P.; Dale, Anders; Posthuma, Danielle; Andreassen, Ole Andreas; Karch, Celeste M. & Desikan, Rahul S (2018). Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.. Acta Neuropathologica. ISSN 0001-6322. . doi: 10.1007/s00401-018-1928-6
Chen, Haitao; Ewing, Charles M; Zheng, Sigun; Grindedal, Eli Marie; Cooney, Kathleen A.; Wiley, Kathleen E.; Djurovic, Srdjan; Andreassen, Ole Andreas; Axcrona, Karol; Mills, Ian Geoffrey; Xu, Jianfeng; Mæhle, Lovise Olaug; Fosså, Sophie Dorothea & Isaacs, William B. (2018). Genetic factors influencing prostate cancer risk in Norwegian men. The Prostate. ISSN 0270-4137. 78(3), s 186- 192 . doi: 10.1002/pros.23453 Full text in Research Archive.
Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R.; Pearlson, Godfrey D.; Potkin, Steven G.; Van Erp, Theo G.M.; Macciardi, Fabio; Ehrlich, Stefan; Ho, Beng-Choon; Sponheim, Scott R.; Wang, Lei; Stephen, Julia M.; Mayer, Julia M.; Hanlon, Faith M.; Jung, Rex E.; Clementz, Brett A.; Keshavan, Matcheri S.; Gershon, Elliot S.; Sweeney, John A.; Tamminga, Carol A.; Andreassen, Ole Andreas; Agartz, Ingrid; Westlye, Lars Tjelta; Sui, Jing; Du, Yuhui; Turner, Jessica A. & Liu, Jingyuan (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin. ISSN 0586-7614. 45(1), s 222- 232 . doi: 10.1093/schbul/sby010
Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; van der Meer, Dennis; Alnæs, Dag; Rokicki, Jaroslav; Moberget, Torgeir; Sønderby, Ida Elken; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), s 1049- 1059 . doi: 10.1038/s41431-018-0134-2
Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Christoforou, Andrea; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd & Deary, Ian J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. ISSN 2041-1723. 9(2098), s 1- 16 . doi: 10.1038/s41467-018-04362-x Full text in Research Archive.
de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Thompson, Wesley Kurt; Wang, Yunpeng; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Andreassen, Ole Andreas; Mattingsdal, Morten; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A. & Breen, Gerome (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. ISSN 2399-3642. 1(163) . doi: 10.1038/s42003-018-0155-y Full text in Research Archive.
Demmo, Christine; Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Hellvin, Tone; Simonsen, Carmen Elisabeth; Haatveit, Beathe Almenning; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2018). Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study. Bipolar Disorders. ISSN 1398-5647. 20(3), s 228- 237 . doi: 10.1111/bdi.12569 Show summary
OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. METHODS: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first-treatment (FT) BD I patients (N = 42), with and without relapse, during a 1-year follow-up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). RESULTS: Compared to both patients with relapse and healthy controls, no-relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no-relapse patients, reduction of symptoms was associated with neurocognitive improvement. No-relapse patients showed better global and occupational functioning. CONCLUSIONS: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow-up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery.
Demontis, Ditte; Walters, Raymond K.; Martin, Joanna; Mattheisen, Manuel; Als, Thomas D.; Agerbo, Esben; Baldursson, Gisli; Belliveau, Rich; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Churchhouse, Claire; Dumont, Ashley; Gandal, Michael; Goldstein, Jacqueline I.; Grasby, Katrina L.; Grove, Jakob; Gudmundsson, Ólafur O.; Hansen, Christine S; Hauberg, Mads Engel; Hollegaard, Mads V; Howrigan, Daniel P.; Huang, Hailiang; Jugessur, Astanand; Myhre, Ronny; Stoltenberg, Camilla; Andreassen, Ole Andreas; Asherson, Philip; Burton, Christie L.; Boomsma, Dorret I.; Cormand, Bru; Dalsgaard, Søren; Haavik, Jan; Sonuga-Barke, Edmund J.S.; Sullivan, Patrick F.; Thapar, Anita; Tung, Joyce Y.; Waldman, Irwin; Medland, Sarah E.; Stefansson, Kari; Nordentoft, Merete; Hougaard, David M.; Werge, Thomas; Mors, Ole; Mortensen, Preben Bo; Daly, Mark J.; Faraone, Stephen V.; Børglum, Anders D. & Neale, Benjamin M (2018). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. ISSN 1061-4036. 51, s 63- 75 . doi: 10.1038/s41588-018-0269-7 Full text in Research Archive.
Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139, s 37- 45 . doi: 10.1111/acps.12971
Drange, Ole Kristian; Vaaler, Arne; Morken, Gunnar; Andreassen, Ole Andreas; Malt, Ulrik Fredrik & Finseth, Per Ivar (2018). Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study. International journal of bipolar disorders. ISSN 2194-7511. 6(19) . doi: 10.1186/s40345-018-0128-6 Full text in Research Archive.
Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha; Chen, Chi-Hua; Kuperman, Joshua M.; Hagler, Donald J.; Steen, Vidar Martin; Le Hellard, Stephanie; Håberg, Asta; Espeseth, Thomas; Andreassen, Ole Andreas; Dale, Anders; Jernigan, Terry L. & Halgren, Eric (2018). Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational psychiatry. ISSN 2158-3188. 8:114(1), s 1- 8 . doi: 10.1038/s41398-018-0166-y Full text in Research Archive.
Fan, Chun Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Chen, Chi-Hua; Holland, Dominic; Lo, Min-Tzu; Sundar, Vijay S.; Frei, Oleksandr; Jernigan, Terry L.; Andreassen, Ole Andreas & Dale, Anders (2018). Beyond heritability: Improving discoverability in imaging genetics. Human Molecular Genetics. ISSN 0964-6906. 27(1), s R22- R28 . doi: 10.1093/hmg/ddy082
Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel; Andreassen, Ole Andreas & Spigset, Olav (2018). Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry. ISSN 0924-9338. 48, s 71- 78 . doi: 10.1016/j.eurpsy.2017.04.001
Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg; Dieset, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid; Marder, Stephen R. & Melle, Ingrid (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research. ISSN 0165-1781. 267, s 140- 147 . doi: 10.1016/j.psychres.2018.05.065 Full text in Research Archive.
Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid & Steen, Vidar Martin (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. ISSN 0920-9964. 197, s 253- 260 . doi: 10.1016/j.schres.2017.10.042 Full text in Research Archive. Show summary
Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.
Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Vidar Martin & Agartz, Ingrid (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 282, s 55- 63 . doi: 10.1016/j.pscychresns.2018.10.001
Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(7), s 795- 802 . doi: 10.1007/s00406-018-0897-z Full text in Research Archive.
Gurholt, Tiril Pedersen; Osnes, Kåre; Nerhus, Mari; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-29141-y Full text in Research Archive.
Hartberg, Cecilie Bhandari; Lange, Elisabeth Heffermehl; Lagerberg, Trine Vik; Haukvik, Unn Kristin H.; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use. European Neuropsychopharmacology. ISSN 0924-977X. 28(1), s 37- 47 . doi: 10.1016/j.euroneuro.2017.11.019
Hibar, Derrek; Westlye, Lars Tjelta; Doan, Nhat Trung; Jahanshad, Neda; Cheung, J. W.; Ching, Christopher R K; Versace, Amelia; Bilderbeck, A; Uhlmann, Anne; Mwangi, B; Krämer, B; Overs, B; Hartberg, Cecilie Bhandari; Abé, Christoph; Dima, Danai; Grotegerd, Dominik; Sprooten, Emma; Bøen, Erlend; Jimenez, Enrique; Howells, Fleur M.; Delvecchio, G; Temmingh, H; Starke, J; Almeida, JRC; Goikolea, JM; Houenou, J; Beard, Lauren M.; Rauer, L; Abramovic, Lucija; Bonnin, M.; Ponteduro, MF; Keil, M; Rive, MM; Yao, N; Yalin, N; Najt, P; Rosa, PG; Redlich, Ronny; Trost, S; Hagenaars, Saskia; Fears, SC; Alonso-Lana, S; Van Erp, TGM; Nickson, Thomas; Chaim-Avancini, TM; Meier, TB; Elvsåshagen, Torbjørn; Haukvik, Unn Kristin H.; Lee, Who-Seung; Schene, AH; Lloyd, AJ; Young, AH; Nugent, Allison C; Dale, AM; Pfennig, Andrea; McIntosh, AM; Lafer, Beny; Baune, BT; Ekman, CJ; Zarate, CA; Bearden, CE; Henry, C; Simhandl, Christian; McDonald, C; Bourne, C; Stein, DJ; Wolf, DH; Cannon, DM; Glahn, DC; Veltman, DJ; Pomarol-Clotet, E; Vieta, E; Canales-Rodriguez, EJ; Nery, FG; Duran, FLS; Busatto, GF; Roberts, G; Pearlson, GD; Goodwin, GM; Kugel, H; Whalley, HC; Ruhe, HG; Soares, JC; Fullerton, JM; Rybakowski, JK; Savitz, Jonathan; Chaim, KT; Fatjo-Vilas, Mar; Soeiro-de-Souza, MG; Boks, MP; Zanetti, MV; Otaduy, MCG; Schaufelberger, MS; Alda, Martin; Ingvar, Martin; Phillips, ML; Kempton, MJ; Bauer, M; Landén, M; Lawrence, NS; Van Haren, NEM; Horn, NR; Freimer, NB; Gruber, Oliver; Schofield, PR; Mitchell, PB; Kahn, RS; Lenroot, R; Machado-Vieira, R; Ophoff, RA; Sarró, S; Frangou, Sophia; Satterthwaite, TD; Hajek, Tomas; Dannlowski, Udo; Malt, Ulrik Fredrik; Arolt, Volker; Gattaz, WF; Drevets, WC; Caseras, Xavier; Agartz, Ingrid; Thompson, PM & Andreassen, Ole Andreas (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 932- 942 . doi: 10.1038/mp.2017.73 Full text in Research Archive.
Holmen, Tom Langerud; Engh, John; Andersen, Eivind; Andreassen, Ole Andreas; Martinsen, Egil Wilhelm; Bigseth, Therese Torgersen; Bang-Kittilsen, Gry & Egeland, Jens (2018). Cardio-respiratory fitness is associated with a verbal factor across cognitive domains in schizophrenia. Schizophrenia Research. ISSN 0920-9964. . doi: 10.1016/j.schres.2018.11.033 Full text in Research Archive. Show summary
Abstract Objective We investigated whether the relationship between cardio-respiratory fitness (CRF) and cognition in schizophrenia is general, or due to selective relationships between CRF and specific aspects of cognitive function. Method Eighty outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale version 4 General Ability Index (WAIS GAI), the MATRICS Consensus Cognitive Battery (MCCB) and the Emotion in Biological Motion (EBM) test. CRF was assessed with peak oxygen uptake measured directly during maximum exercise using a modified Balke protocol. Partial correlations, controlling for sex and age, were obtained for the perceptual and the verbal indices of WAIS GAI, six cognitive domains of MCCB, and the EBM total score. A factor analysis was conducted on all 15 subtests of the WAIS GAI and the MCCB, and the factors were subjected to separate regression analyses with CRF as predictor. Results Significant, moderately sized correlations were found between CRF and all cognitive domains except processing speed. The correlation appeared strongest for CRF and the Verbal Comprehension Index of WAIS GAI (r = 0.29, p = .005). The factor analysis identified three factors: one speed/attention/executive function factor, one verbal factor, and one perceptual factor. Regression analyses showed that VO2peak explained a significant amount of variance in the verbal factor only (R2 = 0.06, β = 0.329, p = .03). Conclusion The results indicate that the relationship between CRF and cognition in schizophrenia is selectively tied to a modality-specific association with verbal cognitive abilities. These findings have implications for understanding the relation between cognitive factors and physical health in schizophrenia.
Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports. ISSN 2045-2322. 8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Full text in Research Archive.
Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry. ISSN 2158-3188. 8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Full text in Research Archive.
Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn; Athanasiu, Lavinia; Melbø-Jørgensen, Christian; Hassani, Sahar; Hoeffding, Louise K.; Herms, Stefan; Bergen, Sarah E.; Karlsson, Robert; Song, Jie; Rietschel, Marcella; Nöthen, Markus M.; Forstner, Andreas J.; Hoffmann, Per; Hultman, Christina M.; Landén, Mikael; Cichon, Sven; Werge, Thomas; Andreassen, Ole Andreas; Le Hellard, Stephanie & Djurovic, Srdjan (2018). Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational psychiatry. ISSN 2158-3188. 8(210), s 1- 10 . doi: 10.1038/s41398-018-0175-x Full text in Research Archive.
Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep. ISSN 0161-8105. 41(10) . doi: 10.1093/sleep/zsy145 Full text in Research Archive.
Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Yokoyama, Jennifer S.; Kouri, Naomi; Ross, Owen A.; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Schellenberg, Gerard D.; Sleiman, Patrick M.; Momeni, Parastoo; Hess, Christopher P.; Miller, Bruce L.; Sharma, Manu; Van Deerlin, Vivianna M.; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2018). Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum. JAMA Neurology. ISSN 2168-6149. 75(7), s 860- 875 . doi: 10.1001/jamaneurol.2018.0372
Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry. ISSN 2168-6238.
Kauppi, Karolina; Fan, Chun Chieh; McEvoy, Linda K.; Holland, Dominic; Tan, Chin Hong; Chen, Chi-Hua; Andreassen, Ole Andreas; Desikan, Rahul S. & Dale, Anders M. (2018). Combining polygenic hazard score with volumetric MRI and cognitive measures improves prediction of progression from mild cognitive impairment to Alzheimer's disease. Frontiers in Neuroscience. ISSN 1662-4548. 12 . doi: 10.3389/fnins.2018.00260 Full text in Research Archive.
Kauppi, Karolina; rosenthal, sara brin; Lo, Min-Tzu; Sanyal, Nilotpal; Jiang, Mian; Abagyan, Ruben; McEvoy, Linda K.; Andreassen, Ole Andreas & Chen, Chi-Hua (2018). Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia. American Journal of Psychiatry. ISSN 0002-953X. 175(7), s 674- 682 . doi: 10.1176/appi.ajp.2017.17040410 Full text in Research Archive.
Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid; Alloza, C; Andreassen, Ole Andreas; Arango, C; Banaj, Nerisa; Bouix, S; Bousman, CA; Brouwer, RM; Bruggemann, J; Bustillo, Juan R; Cahn, Wiepke; Calhoun, Vince; Cannon, Dara M; Carr, Vaughan J.; Catts, Stanley V.; Chen, J; Chen, JX; Chen, X; Chiapponi, C; Cho, KK; Ciullo, Valentina; Corvin, A; Crespo-Facorro, Benedicto; Cropley, V; De Rossi, Pietro; Diaz-Caneja, CM; Dickie, EW; Ehrlich, S; Fan, FM; Faskowitz, Joshua; Fatouros-Bergman, Helena; Flyckt, Lena; Ford, JM; Fouche, JP; Fukunaga, Masaki; Gill, M; Glahn, DC; Gollub, Randy L; Goudzwaard, ED; Guo, H; Gur, RE; Gur, RC; Gurholt, Tiril Pedersen; Hashimoto, Ryota; Hatton, SN; Henskens, FA; Hibar, DP; Hickie, IB; Hong, LE; Horacek, Jan; Howells, FM; Hulshoff Pol, Hilleke E; Hyde, CL; Isaev, D; Jablensky, Assen; Jansen, PR; Janssen, J; Jönsson, Erik Gunnar; Jung, LA; Kahn, RS; Kikinis, Z; Liu, K; Klauser, Paul; Knöchel, C; Kubicki, M; Lagopoulos, Jim; Langen, C; Lawrie, Stephen M; Lenroot, R; Lim, KO; Lopez-Jaramillo, Carlos; Lyall, A; Magnotta, V; Mandl, RCW; Mathalon, DH; McCarley, RW; McCarthy-Jones, Simon; McDonald, C; McEwen, S; McIntosh, A; Melicher, T; Mesholam-Gately, RI; Michie, PT; Mowry, Bryan J.; Mueller, BA; Newell, DT; O'donnell, P; Oertel-Knöchel, V; Oestreich, L; Paciga, SA; Pantelis, Christos; Pasternak, O; Pearlson, Godfrey D; Pellicano, GR; Pereira, A; Pineda Zapata, J; Piras, Fabrizio; Potkin, SG; Preda, Adrian; Rasser, PE; Roalf, DR; Roiz, R; Roos, A; Rotenberg, D; Satterthwaite, TD; Savadjiev, P; Schall, Ulrich; Scott, RJ; Seal, ML; Seidman, LJ; Shannon Weickert, C; Whelan, CD; Shenton, ME; Kwon, JS; Spalletta, Gianfranco; Spaniel, F; Sprooten, Emma; Stäblein, M; Stein, DJ; Sundram, S; Tan, Y; Tan, S; Tang, S; Temmingh, HS; Westlye, Lars Tjelta; Tønnesen, Siren; Tordesillas-Gutierrez, Diana; Doan, Nhat Trung; Vaidya, Jatin G.; Van Haren, NEM; Vargas, CD; Vecchio, D; Velakoulis, D; Voineskos, Aristotle N.; Voyvodic, JQ; Wang, Z; Wan, P; Wei, D; Weickert, TW; Whalley, Heather Clare; White, T; Whitford, TJ; Wojcik, JD; XIANG, HUA; Xie, Z; Yamamori, Hidenaga; Yang, F; Yao, N; Zhang, G.; Zhao, J; Van Erp, Theo G M; Turner, J; Thompson, PM & Donohoe, Gary (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 1261- 1269 . doi: 10.1038/mp.2017.170 Full text in Research Archive.
Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Moberget, Torgeir; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro. ISSN 2373-2822. 5(4), s 1- 13 . doi: 10.1523/ENEURO.0092-18.2018 Full text in Research Archive.
Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
Kulkarni, Rishikesh U; Vandenberghe, Matthieu; Thunemann, Martin; James, Feroz; Andreassen, Ole Andreas; Djurovic, Srdjan; Devor, Anna & Miller, Evan W (2018). In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes. ACS Central Science. ISSN 2374-7943. 4(10), s 1371- 1378 . doi: 10.1021/acscentsci.8b00422 Full text in Research Archive.
Kvam, Tor-Morten; Stewart, Lowan H. & Andreassen, Ole Andreas (2018). Psykedeliske stoffer i behandling av angst, depresjon og avhengighet. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(18) . doi: 10.4045/tidsskr.17.1110
LeBlanc, Marissa; Zuber, Verena; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Frigessi Di Rattalma, Arnoldo & Kulle, Bettina (2018). A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework. BMC Genomics. ISSN 1471-2164. 19:494, s 1- 15 . doi: 10.1186/s12864-018-4859-7 Full text in Research Archive.
Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Wang, Yunpeng (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 177(4), s 454- 467 . doi: 10.1002/ajmg.b.32634
Li, Yi; Barkovich, Matthew J.; Karch, Celeste M.; Nillo, Ryan M.; Fan, Chun-Chieh; Broce, Iris J.; Tan, Chin Hong; Cuneo, Daniel; Hess, Christopher P.; Dillon, William P.; Glenn, Orit A.; Glastonbury, Christine M.; Olney, Nicholas; Yokoyama, Jennifer S.; Bonham, Luke W.; Miller, Bruce; Kao, Aimee; Schmansky, Nicholas; Fischl, Bruce; Andreassen, Ole Andreas; Jernigan, Terry; Dale, Anders; Barkovich, A. James; Desikan, Rahul S. & Sugrue, Leo P. (2018). Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Scientific Reports. ISSN 2045-2322. 8:13373, s 1- 10 . doi: 10.1038/s41598-018-31075-4 Full text in Research Archive.
Logue, Mark W.; Panizzon, Matthew S.; Elman, Jeremy A.; Gillespie, Nathan A.; Hatton, Sean N.; Gustavson, Daniel E.; Andreassen, Ole Andreas; Dale, Anders; Franz, Carol E.; Lyons, Michael J.; Neale, Michael C.; Reynolds, Chandra A.; Tu, Xin & Kremen, William S. (2018). Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Molecular Psychiatry. ISSN 1359-4184. s 1- 10 . doi: 10.1038/s41380-018-0030-8
Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Metzner, Christoph; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2018). A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. Journal of Neuroscience Methods. ISSN 0165-0270. 293, s 264- 283 . doi: 10.1016/j.jneumeth.2017.10.007 Full text in Research Archive.
McCarthy, Michael J.; Wei, Heather; Nievergelt, Caroline M.; Stautland, Andrea; Maihofer, Adam X.; Welsh, David K; Shilling, Paul D.; Alda, Martin; Alley-Rodriguez, Ney; Anand, Anit; Andreassen, Ole Andreas; Balaraman, Yokesh; Berrettini, Wade H; Bertram, Holli; Brennand, Kristen J.; Calabrese, Joseph R.; Calkin, Cynthia V.; Claasen, Ana; conroy, Clara; Coryell, William H.; Craig, David; D´Arcangelo, Nicole; DeModena, Anna; Djurovic, Srdjan; Feeder, Scott; Gage, Fred H.; Jakobsen, Petter; Karberg, Elizabeth; Kelly, Marissa; Leckband, Susan G.; Lohoff, Falk; McInnis, Melvin G.; Mondimore, Francis; Morken, Gunnar; Nurnberger, John I.; Obral, Sarah; Ødegaard, Ketil Joachim; Ortiz, Abigail; Ritchey, Megan; Ryan, Kelly; Schinagle, Martha; Schøyen, Helle Kristine; Schwebel, Candice; Shaw, Martha; Shekhtman, Tatyana; Slaney, Clare; Stapp, Emma; Szelinger, Szabolcs; Tarwater, Bruce; Zandi, Peter P. & Kelsoe, John R. (2018). Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. ISSN 0893-133X. 44(3), s 620- 628 . doi: 10.1038/s41386-018-0273-8 Full text in Research Archive. Show summary
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patients, we measured circadian rhythms in fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-R patients were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP3 signaling pathway may account for some of the individual differences in the effects of lithium on cellular rhythms. We conclude that circadian rhythms may influence response to lithium in maintenance treatment of BD.
Mørch-Johnsen, Lynn; Nerland, Stener; Jørgensen, Kjetil Nordbø; Osnes, Kåre; Hartberg, Cecilie Bhandari; Andreassen, Ole Andreas; Melle, Ingrid; Nesvåg, Ragnar & Agartz, Ingrid (2018). Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. Bipolar Disorders. ISSN 1398-5647. 20(7), s 647- 657 . doi: 10.1111/bdi.12627
Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid; Andreassen, Ole Andreas & Jönsson, Erik Gunnar (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-28160-z Full text in Research Archive.
Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir; Rokicki, Jaroslav; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.09.027 Full text in Research Archive.
Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodriguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine Vik; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Mwangi, Benson; Nabulsi, Leila; Opel, Nils; Overs, Bronwyn J.; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Redlich, Ronny; Roberts, Gloria; Rosa, Pedro G.; Salvador, Raymond; Satterthwaite, Theodore D.; Soares, Jair C.; Stein, Dan J.; Temmingh, Henk S.; Trappenberg, Thomas; Uhlmann, Anne; van Haren, Neeltje E.M.; Vieta, Eduard; Westlye, Lars Tjelta; Wolf, Daniel H.; Yüksel, Dilara; Zanetti, Marcus V.; Andreassen, Ole Andreas; Thompson, Paul M. & Hájek, Tomás (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-018-0228-9 Full text in Research Archive.
Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E.; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L.; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H.; McCarroll, Steven A.; Baune, Bernhard T.; Breen, Gerome; Byrne, Enda M.; Dannlowski, Udo; Eley, Thalia C.; Hayward, Caroline; Martin, Nicholas G.; McIntosh, Andrew M.; Plomin, Robert; Porteous, David J.; Wray, Naomi R.; Caballero, Armando; Geschwind, Daniel H.; Huckins, Laura M.; Ruderfer, Douglas M.; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A.; Won, Hyejung; Agerbo, Esben; Als, Thomas D.; Andreassen, Ole Andreas; Bækvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bøcker; Børglum, Anders D.; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giørtz; Golimbet, Vera; Grove, Jakob; Hougaard, David M.; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Søholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; Collier, David A; Owen, Michael J; O'Donovan, Michael C; Walters, James T R; Collier, David A.; Rujescu, Dan; Kirov, George; Owen, Michael J.; O'Donovan, Michael C. & Walters, James T.R. (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. ISSN 1061-4036. 50(3), s 381- 389 . doi: 10.1038/s41588-018-0059-2
Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alxander W.; Ori, Anil P.S.; Domenici, Enrico; Di Florio, A; Papiol, S; Kalman, Janos; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Joa, Inge; Malt, Ulrik Fredrik; Mattingsdal, Morten; Melle, Ingrid; Morken, Gunnar; Nordentoft, Merete; Nordin, Annelie; Ødegaard, Ketil Joachim; Smeland, Olav Bjerkehagen; Stordal, Eystein; Vaaler, Arne; Wang, Yunpeng; Zheng, Xuebin; Zimprich, Fritz; Zöllner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole Andreas; Hong Lee, S; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela & Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.. Cell. ISSN 0092-8674. 173(7), s 1705- 1715 . doi: 10.1016/j.cell.2018.05.046
Quintana, Daniel; Smerud, Knut Terje; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Evidence for intranasal oxytocin delivery to the brain: Recent advances and future perspectives. Therapeutic delivery. ISSN 2041-5990. 9(7), s 515- 525 . doi: 10.4155/tde-2018-0002 Full text in Research Archive.
Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Kaufmann, Tobias; Mahmoud, Ramy A.; Smerud, Knut Terje; Djupesland, Per G. & Andreassen, Ole Andreas (2018). Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study. Neuropsychopharmacology. ISSN 0893-133X. 44, s 306- 313 . doi: 10.1038/s41386-018-0241-3
Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut Terje; Mahmoud, Ramy A.; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior. ISSN 0018-506X. 102, s 85- 92 . doi: 10.1016/j.yhbeh.2018.05.004
Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders; Doan, Nhat Trung; Monereo Sanchez, Jennifer; Alnæs, Dag; Ulrichsen, Kristine Moe; Dørum, Erlend Solberg; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ. ISSN 2167-8359. . doi: 10.7717/peerj.5908 Full text in Research Archive. Show summary
Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequately characterized. Exploring differential brain age models driven by tissue- specific classifiers provides a hitherto unexplored opportunity to disentangle indepen- dent sources of heterogeneity in brain biology. We trained machine-learning models to estimate brain age using various combinations of FreeSurfer based morphometry and diffusion tensor imaging based indices of white matter microstructure in 612 healthy controls aged 18–87 years. To compare the tissue-specific brain ages and their cognitive sensitivity, we applied each of the 11 models in an independent and cognitively well- characterized sample ( n = 265, 20–88 years). Correlations between true and estimated age and mean absolute error (MAE) in our test sample were highest for the most comprehensive brain morphometry ( r = 0 . 83, CI:0.78–0.86, MAE = 6.76 years) and white matter microstructure ( r = 0 . 79, CI:0.74–0.83, MAE = 7.28 years) models, confirming sensitivity and generalizability. The deviance from the chronological age were sensitive to performance on several cognitive tests for various models, including spatial Stroop and symbol coding, indicating poorer performance in individuals with an over-estimated age. Tissue-specific brain age models provide sensitive measures of brain integrity, with implications for the study of a range of brain disorders.
Ringen, Petter Andreas; Falk, Ragnhild Sørum; Antonsen, Bjørnar Torske; Færden, Ann; Mamen, Asgeir; Rognli, Eline Borger; Solberg, Dag Kristen; Martinsen, Egil Wilhelm & Andreassen, Ole Andreas (2018). Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: A naturalistic interventional study. BMC Psychiatry. ISSN 1471-244X. 18 . doi: 10.1186/s12888-018-1832-6 Full text in Research Archive.
Ringen, Petter Andreas; Færden, Ann; Antonsen, Bjørnar Torske; Falk, Ragnhild Sørum; Mamen, Asgeir; Rognli, Eline Borger; Solberg, Dag Kristen; Andreassen, Ole Andreas & Martinsen, Egil Wilhelm (2018). Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-term psychiatric inpatient departments. Nordic Journal of Psychiatry. ISSN 0803-9488. 72(4), s 296- 302 . doi: 10.1080/08039488.2018.1449012 Full text in Research Archive.
Rosenvinge, Jan H; Andreassen, Ole Andreas & Rø, Øyvind (2018). Spiseforstyrrelser, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.), Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. Kapittel 19. s 571 - 598
Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A.; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B.; Coleman, Jonathan R.I.; Grasby, Katrina L.; Hammerschlag, Anke R.; Kaminski, Jakob A.; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A.; Trampush, Joey W.; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K.; Karlsson, Ida K.; Linnarsson, Sten; Montgomery, Grant W.; Muñoz-Manchado, Ana B.; Quinlan, Erin B.; Schumann, Gunter; Skene, Nathan G.; Webb, Bradley T.; White, Tonya; Arking, Dan E.; Avramopoulos, Dimitrios; Bilder, Robert M.; Bitsios, Panos; Burdick, Katherine E.; Cannon, Tyrone D.; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T.; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J.; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G.; Espeseth, Thomas; Freimer, Nelson A.; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C.; Hariri, Ahmad; Hatzimanolis, Alex; Keller, Matthew C.; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C.; London, Edythe; Lundervold, Astri; Malhotra, Anil K.; Melle, Ingrid; Morris, Derek; Need, Anna C.; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A.; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W.; Scult, Matthew A; Smeland, Olav Bjerkehagen; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar Martin; Stefanis, Nikos C.; Straub, Richard E.; Sundet, Kjetil Søren; Tiemeier, Henning; Voineskos, Aristotle N.; Weinberger, Daniel R.; Widén, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole Andreas; Breen, Gerome; Christiansen, Lene; Debrabant, Birgit; Dick, Danielle M.; Heinz, Andreas; Hjerling-Leffler, Jens; Ikram, M. Arfan; Kendler, Kenneth S.; Martin, Nicholas G.; Medland, Sarah E.; Pedersen, Nancy L.; Plomin, Robert; Polderman, Tinca J.C.; Ripke, Stephan; van der Sluis, Sophie; Sullivan, Patrick F.; Vrieze, Scott I; Wright, Margaret J. & Posthuma, Daniëlle (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics. ISSN 1061-4036. 50, s 912- 919 . doi: 10.1038/s41588-018-0152-6
Seibert, Tyler M.; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Parsons, J. Kellogg; Eeles, Rosalind A.; Easton, Douglas F.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Garcia, Sara Benlloch; Muir, Kenneth; Grönberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; Tammela, Teuvo L.J.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weischer, Maren; Bisbjerg, Rasmus; Røder, M. Andreas; Iversen, Peter; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Cuk, Katarina; Saum, Kai-Uwe; Park, Jong Y.; Sellers, Thomas A.; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Clements, Judith A.; Spurdle, Amanda; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Karow, David S.; Mills, Ian Geoffrey; Andreassen, Ole Andreas & Dale, Anders (2018). Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ. British Medical Journal. ISSN 1756-1833. 360:j5757, s 1- 7 . doi: 10.1136/bmj.j5757 Full text in Research Archive.
Simonsen, Carmen Elisabeth; Færden, Ann; Ueland, Torill; Vaskinn, Anja; Bjella, Thomas; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2018). Self-rated disability in first treated episode of psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 85, s 48- 54 . doi: 10.1016/j.comppsych.2018.06.004 Full text in Research Archive.
Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?. Scandinavian Journal of Psychology. ISSN 0036-5564. 59(1), s 26- 31 . doi: 10.1111/sjop.12407
Smelror, Runar; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Kelleher, Ian; Cannon, Mary; DeRosse, Pamela; Malhotra, Anil K.; Karlsgodt, Katherine H. ; Andreassen, Ole Andreas; Lundberg, Mathias; Edbom, Tobias; Cleland, Neil; Ueland, Torill; Myhre, Anne Margrethe; Rund, Bjørn Rishovd & Agartz, Ingrid (2018). Healthy adolescent performance with standardized scoring tables for the MATRICS Consensus Cognitive Battery: A multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 45(4), s 773- 783 . doi: 10.1093/schbul/sby131
Smoller, Jordan W.; Andreassen, Ole Andreas; Edenberg, Howard J.; Faraone, Stephen V.; Glatt, Stephen J. & Kendler, Kenneth Seedman (2018). Psychiatric genetics and the structure of psychopathology. Molecular Psychiatry. ISSN 1359-4184. s 1- 12 . doi: 10.1038/s41380-017-0010-4
Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke; Berg-Hansen, Pål; Moen, Stine Marit; Bjørnerud, Atle; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Dale, Anders & Beyer, Mona K. (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. s 1- 12 . doi: 10.1177/1352458518765671 Full text in Research Archive.
Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports. ISSN 2045-2322. 8:12585, s 1- 9 . doi: 10.1038/s41598-018-30387-9 Full text in Research Archive.
Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E.; Sullivan, Patrick F.; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M. & Steen, Vidar Martin (2018). Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes. Scientific Reports. ISSN 2045-2322. 8(6915), s 1- 8 . doi: 10.1038/s41598-018-25280-4 Full text in Research Archive.
Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra; Espeseth, Thomas; Vaskinn, Anja; Wang, Yunpeng; Westlye, Lars Tjelta; Jacquemont, Sébastien; Djurovic, Srdjan; Stefánsson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. s 1- 16 . doi: 10.1038/s41380-019-0358-8 Full text in Research Archive.
Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle; Vandenberghe, Matthieu; Sadegh, Sanaz; Saisan, Payam A.; Cheng, Qun; Weldy, Kimberly L.; Lyu, Hongming; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Devor, Anna & Kuzum, Duygu (2018). Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nature Communications. ISSN 2041-1723. 9:2015, s 1- 12 . doi: 10.1038/s41467-018-04457-5 Full text in Research Archive.
Torske, Tonje; Nærland, Terje; Øie, Merete Glenne; Stenberg, Nina & Andreassen, Ole Andreas (2018). Metacognitive aspects of executive function are highly associated with social functioning on parent-rated measures in children with Autism Spectrum Disorder. Frontiers in Behavioral Neuroscience. ISSN 1662-5153. 11 . doi: 10.3389/fnbeh.2017.00258
Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-32355-9 Full text in Research Archive.
van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. s 1- 13 . doi: 10.1038/s41380-018-0262-7 Full text in Research Archive.
Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C.; Pearlson, Godfrey D.; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R.; Clark, Vincent P.; Agartz, Ingrid; Mueller, Bryon A.; Cahn, Wiepke; de Zwarte, Sonja M.C.; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ophoff, Roel A.; van Haren, Neeltje E.M.; Andreassen, Ole Andreas; Dale, Anders; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Jørgensen, Kjetil Nordbø; Lagerberg, Trine Vik; Melle, Ingrid; Westlye, Lars Tjelta; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D.; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J.; Catts, Stanley; Cropley, Vanessa L.; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans A.; Jablensky, Assen; Lenroot, Rhoshel K.; Mowry, Bryan J.; Michie, Patricia T.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J.; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; Shannon Weickert, Cynthia; Weickert, Thomas W.; Morris, Derek W.; Hong, Elliot; Kochunov, Peter; Beard, Lauren M.; Gur, Raquel E.; Gur, Ruben C.; Satterthwaite, Theodore D; Wolf, Daniel H.; Belger, Aysenil; Brown, Gregory G.; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel H.; O'Leary, Daniel S.; Potkin, Steven G.; Preda, Adrian; Voyvodic, James; Lim, Kelvin O.; McEwen, Sarah; Yang, Fude; Tan, Yunlong; Tan, Shuping; Wang, Zhiren; Fan, Fengmei; Chen, Jingxu; Xiang, Hong; Tang, Shiyou; Guo, Hua; Wan, Ping; Wei, Dong; Bockholt, Henry J.; Ehrlich, Stefan; Wolthusen, Rick P.F.; King, Margaret D.; Shoemaker, Jody M.; Sponheim, Scott R.; De Haan, Lieuwe; Koenders, Laura; Machielsen, Marise W.; van Amelsvoort, Therese; Veltman, Dick J.; Assogna, Francesca; Banaj, Nerisa; de Rossi, Pietro; Iorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; McKenna, Peter J.; Pomarol-Clotet, Edith; Salvador, Raymond; Corvin, Aiden; Donohoe, Gary; Kelly, Sinead; Whelan, Christopher D.; Dickie, Erin W.; Rotenberg, David; Voineskos, Aristotle N.; Ciufolini, Simone; Radua, Joaquim; Dazzan, Paola; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; Egloff, Laura; Harrisberger, Fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; Wang, Lei; Jönsson, Erik Gunnar; Koops, Sanne; Sommer, Iris Else Clara; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Stephen, Julia M.; Kwon, Jun Soo; Yun, Je-Yeon; Cannon, Dara M.; McDonald, Colm; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; Fatouros-Bergman, Helena & Flyckt, Lena (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.04.023 Full text in Research Archive.
Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; wenhao, jiang; Glahn, David C; Pearlson, Godfrey D; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Clark, Vincent P; Mueller, Bryon A; de Zwarte, Sonja M.C.; Ophoff, Roel A; Van Haren, Neeltje E M; Andreassen, Ole Andreas; Gurholt, Tiril Pedersen; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Calhoun, Vince D; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; tordesillas-guiterrez, diana; Loughland, Carmel M; Catts, Stanley; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans; Jablensky, Assen; Mowry, Bryan J.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; weickert, cynthia; Weickert, Thomas W.; Hong, Elliot; Kochunov, Peter; Gur, Raquel E; Gur, Ruben C; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel; Potkin, Steven G; Preda, Adrian; Fan, Fengmei; Ehrlich, Stefan; King, Margaret D.; De Haan, Lieuwe; Veltman, Dick J; Assogna, Francesca; Banaj, Nerisa; De Rossi, Pietro; Lorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; Pomarol-Clotet, Edith; Kelly, Sinéad; Ciufollini, Simone; Radua, Joaquim; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; schonborn-harrisberger, fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; bertolino, allessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Yun, Je-Yeon; Cannon, Dara M; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; fatouros-bergmann, helena; Flyckt, Lena; Farde, Lars; Cervenka, Simon; Agartz, Ingrid; Collste, Karin; Victorsson, Pauliina; Engberg, Göran; Erhardt, Sophie; Schwieler, Lilly; Malmqvist, Anna; Hedberg, Mikael; Orhan, Funda; Piehl, Fredrik; Rosa, Pedro GP; Serpa, Mauricio H; Zanetti, Marcus V; Hoschl, Cyril; Škoch, Antonín; Spaniel, Filip; Tomecek, David; McIntosh, Andrew M.; Whalley, Heather C; Knochel, Christian; oertel-knöchel, viola; Howells, Fleur M; Stein, Dan J.; Temmingh, Henk S.; Uhlmann, Anne; Lopez-Jaramillo, Carlos; Dima, Danai; Faskowitz, Joshua I; Gutman, Boris A; Jahanshad, Neda; Thompson, Paul M & Turner, Jessica A (2018). Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.10.003
Vaskinn, Anja; Andersson, Stein; Østefjells, Tiril; Andreassen, Ole Andreas & Sundet, Kjetil Søren (2018). Emotion perception, non-social cognition and symptoms as predictors of theory of mind in schizophrenia. Comprehensive Psychiatry. ISSN 0010-440X. 85, s 1- 7 . doi: 10.1016/j.comppsych.2018.05.002 Full text in Research Archive.
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole Andreas; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, André G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomáš; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, William T.; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M. Arfan & Fornage, Myriam (2018). Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications. ISSN 2041-1723. 9:3945, s 1- 11 . doi: 10.1038/s41467-018-06234-w Full text in Research Archive.
Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine. ISSN 0033-2917. 48(1), s 82- 94 . doi: 10.1017/S0033291717001283 Full text in Research Archive.
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fred; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod & Andreassen, Ole Andreas (2018). Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-36429-6 Full text in Research Archive.
Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir; Agartz, Ingrid; Buitelaar, Jan K.; Ueland, Torill; Melle, Ingrid; Franke, Barbara; Andreassen, Ole Andreas; Beckmann, Christian F.; Westlye, Lars Tjelta & Marquand, André F. (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry. ISSN 2168-6238. 75(11), s 1146- 1155 . doi: 10.1001/jamapsychiatry.2018.2467
Zak, Nathalia; Moberget, Torgeir; Bøen, Erlend; Boye, Birgitte; Waage, Trine Rygvold; Dietrichs, Espen; Harkestad, Nina; Malt, Ulrik Fredrik; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Andersson, Stein & Elvsåshagen, Torbjørn (2018). Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals. Translational psychiatry. ISSN 2158-3188. 8(103) . doi: 10.1038/s41398-018-0151-5 Full text in Research Archive.
Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bézieau, Stéphane; Dale, Anders; Mills, Ian Geoffrey & Andreassen, Ole Andreas (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. ISSN 2045-2322. 674(8), s 1- 8 . doi: 10.1038/s41598-017-16481-4 Full text in Research Archive.
Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity. ISSN 0889-1591. 65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Full text in Research Archive.
Aas, Monica; Henry, C.; Bellivier, F; Lajnef, M; Gard, S; Kahn, J-P; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Bjella, Thomas; Leboyer, M; Andreassen, Ole Andreas; Melle, Ingrid & Etain, B (2017). Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychological Medicine. ISSN 0033-2917. 47(5), s 902- 912 . doi: 10.1017/S0033291716003081
Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine. ISSN 0033-2917. 47(4), s 669- 679 . doi: 10.1017/S0033291716002762
Aas, Monica; Melle, Ingrid; Bettella, Francesco; Djurovic, Srdjan; Le Hellard, Stephanie; Bjella, Thomas; Ringen, Petter Andreas; Lagerberg, Trine Vik; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Andreassen, Ole Andreas & Tesli, Martin Steen (2017). Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. Psychological Medicine. ISSN 0033-2917. 48(1), s 43- 49 . doi: 10.1017/S0033291717001209 Full text in Research Archive.
Andreassen, Ole Andreas (2017). eHealth provides a novel opportunity to exploit the advantages of the Nordic countries in psychiatric genetic research, building on the public health care system, biobanks, and registries.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 177(7), s 625- 629 . doi: 10.1002/ajmg.b.32561
Athanasiu, Lavinia; Giddaluru, Sudheer; Neto, Carla Patricia Duarte Fernande; Christoforou, Andrea; Reinvang, Ivar; Lundervold, Astri; Nilsson, Lars-Göran; Kauppi, Karolina; Adolfsson, Rolf; Eriksson, Elias; Sundet, Kjetil Søren; Djurovic, Srdjan; Espeseth, Thomas; Nyberg, Lars Erik; Steen, Vidar Martin; Andreassen, Ole Andreas & Le Hellard, Stephanie (2017). A genetic association study of CSMD1 and CSMD2 with cognitive function. Brain, behavior, and immunity. ISSN 0889-1591. 61, s 209- 216 . doi: 10.1016/j.bbi.2016.11.026
Bauer, Michael; Glenn, T; Alda, M; Aleksandrovich, MA; Andreassen, Ole Andreas; Angelopoulos, E; Ardau, R; Ayhan, Y; Baethge, C; Bharathram, SR; Bauer, R; Baune, BT; Becerra-Palars, C; Bellivier, F; Belmaker, RH; Berk, M; Bersudsky, Y; Bicakci, Ş; Birabwa-Oketcho, H; Bjella, Thomas; Bossini, L; Cabrera, J; Cheung, EYW; Del Zompo, M; Dodd, S; Donix, M; Etain, B; Fagiolini, A; Fountoulakis, KN; Frye, MA; Gonzalez-Pinto, A; Gottlieb, JF; Grof, P; Harima, H; Henry, C; Isometsa, ET; Janno, S; Kapczinski, F; Kardell, M; Khaldi, S; Kliwicki, S; König, B; Kot, TL; Krogh, R; Kunz, M; Lafer, B; Landen, M; Larsen, ER; Lewitzka, U; Licht, RW; Lopez-Jaramillo, C; MacQueen, G; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Melle, Ingrid; Meza-Urzua, F; Yee Ming, M; Monteith, S; Morken, Gunnar; Mosca, E; Munoz, R; Mythri, SV; Nacef, F; Nadella, RK; Nery, FG; Nielsen, RE; O'Donovan, C; Omrani, A; Osher, Y; Østermark Sørensen, H; Ouali, U; Pica Ruiz, Y; Pilhatsch, M; Pinna, M; da Ponte, FDR; Quiroz, D; Ramesar, R; Rasgon, N; Reddy, MS; Reif, A; Ritter, P; Rybakowski, JK; Sagduyu, K; Scippa, ÂM; Severus, E; Simhandl, C; Stein, DJ; Strejilevich, S; Subramaniam, M; Sulaiman, AH; Suominen, K; Tagata, H; Tatebayashi, Y; Tondo, L; Torrent, C; Vaaler, Arne; Veeh, J; Vieta, E; Viswanath, B; Yoldi-Negrete, M; Zetin, M; Zgueb, Y & Whybrow, Peter C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 136(6), s 571- 582 . doi: 10.1111/acps.12772
Berg, Akiah Ottesen; Melle, Ingrid; Zuber, Verena; Simonsen, Carmen Elisabeth; Nerhus, Mari; Ueland, Torill; Andreassen, Ole Andreas; Sundet, Kjetil Søren & Vaskinn, Anja (2017). Modelling difficulties in abstract thinking in psychosis: the importance of socio-developmental background. Cognitive Neuropsychiatry. ISSN 1354-6805. 22(1), s 39- 52 . doi: 10.1080/13546805.2016.1259998
Bjørke-Bertheussen, Janette; Schøyen, Helle Kristine; Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Ødegaard, Ketil Joachim; Morken, Gunnar; Sundet, Kjetil Søren; Vaaler, Arne; Auestad, Bjørn Henrik & Kessler, Ute (2017). Right unilateral electroconvulsive therapy does not cause more cognitive impairment than pharmacologic treatment in treatment-resistant bipolar depression: A 6-month randomized controlled trial follow-up study. Bipolar Disorders. ISSN 1398-5647. 20(6), s 531- 538 . doi: 10.1111/bdi.12594
Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Schork, Andrew; Fan, Chun-Chieh; Holland, Dominic; Kauppi, Karolina; Smeland, Olav Bjerkehagen; Djurovic, Srdjan; Sanyal, Nilotpal; Hibar, Derrek; Thompson, Paul M.; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2017). Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Scientific Reports. ISSN 2045-2322. 7:15736, s 1- 9 . doi: 10.1038/s41598-017-15705-x
Church, Chelsea; Andreassen, Ole Andreas; Lorentzen, Steinar; Melle, Ingrid & Aas, Monica (2017). Childhood trauma and minimization/denial in people with and without a severe mental disorder. Frontiers in Psychology. ISSN 1664-1078. 8 . doi: 10.3389/fpsyg.2017.01276
Còrdova Palomera, Aldo; Kaufmann, Tobias; Persson, Karin; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Lund, Martina Jonette; Barca, Maria Lage; Engvig, Andreas; Brækhus, Anne; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum. Scientific Reports. ISSN 2045-2322. 7(40268), s 1- 14 . doi: 10.1038/srep40268 Full text in Research Archive. Show summary
As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.
Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Haatveit, Beathe Christin; Andreassen, Ole Andreas; Ueland, Torill & Ueland, Torill (2017). Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study. Psychiatry Research. ISSN 0165-1781. 249, s 286- 292 . doi: 10.1016/j.psychres.2016.12.048
Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J; Cabral, Howard J; Cupples, L. Adrienne; Thompson, Wesley Kurt; Besser, Lilah; Kukull, Walter A.; Holland, Dominic; Chen, Chi-Hua; Brewer, James B.; Karow, David S.; Kauppi, Karolina; Witoelar, Aree; Karch, Celeste M.; Bonham, Luke W.; Yokoyama, Jennifer S.; Rosen, Howard J.; Miller, Bruce L.; Dillon, William P.; Wilson, David M.; Hess, Christopher P.; Pericak-Vance, Margaret; Haines, Jonathan L.; Farrer, Lindsay A.; Mayeux, Richard; Hardy, John; Goate, Alison M.; Hyman, Bradley T.; Schellenberg, Gerard D.; McEvoy, Linda K.; Andreassen, Ole Andreas & Dale, Anders (2017). Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Nature Methods. ISSN 1548-7091. 14(3:e1002258), s 1- 17 . doi: 10.1371/journal.pmed.1002258
Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen; Fan, Chun Chieh; Schork, Andrew J.; Holland, Dominic; Thompson, Wesley Kurt; Witoelar, Aree; Chen, Chi-Hua; Desikan, Rahul S.; McEvoy, Linda K.; Djurovic, Srdjan; Greengard, Paul; Svenningsson, Per; Einevoll, Gaute & Dale, Anders (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. ISSN 1359-4184. 22(6), s 792- 801 . doi: 10.1038/mp.2017.33 Full text in Research Archive.
Doan, Nhat Trung; Engvig, Andreas; Persson, Karin; Alnæs, Dag; Kaufmann, Tobias; Rokicki, Jaroslav; Còrdova Palomera, Aldo; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum. Scientific Reports. ISSN 2045-2322. 7:45131 . doi: 10.1038/srep45131 Show summary
Recent efforts using diffusion tensor imaging (DTI) have documented white matter (WM) alterations in Alzheimer’s disease (AD). The full potential of whole-brain DTI, however, has not been fully exploited as studies have focused on individual microstructural indices independently. In patients with AD (n = 79), mild (MCI, n = 55) and subjective (SCI, n = 30) cognitive impairment, we applied linked independent component analysis (LICA) to model inter-subject variability across five complementary DTI measures (fractional anisotropy (FA), axial/radial/mean diffusivity, diffusion tensor mode), two crossing fiber measures estimated using a multi-compartment crossing-fiber model reflecting the volume fraction of the dominant (f1) and non-dominant (f2) diffusion orientation, and finally, connectivity density obtained from full-brain probabilistic tractography. The LICA component explaining the largest data variance was highly sensitive to disease severity (AD < MCI < SCI) and revealed widespread coordinated decreases in FA and f1 with increases in all diffusivity measures in AD. Additionally, it reflected regional coordinated decreases and increases in f2, mode and connectivity density, implicating bidirectional alterations of crossing fibers in the fornix, uncinate fasciculi, corpus callosum and major sensorimotor pathways. LICA yielded improved diagnostic classification performance compared to univariate region-of-interest features. Our results document coordinated WM microstructural and connectivity alterations in line with disease severity across the AD continuum.
Doan, Nhat Trung; Engvig, Andreas; Zaske, Krystal; Persson, Karin; Lund, Martina Jonette; Kaufmann, Tobias; Còrdova Palomera, Aldo; Alnæs, Dag; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Nordvik, Jan Egil; Engedal, Knut; Agartz, Ingrid; Selbæk, Geir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples. NeuroImage. ISSN 1053-8119. 158, s 282- 295 . doi: 10.1016/j.neuroimage.2017.06.070 Full text in Research Archive.
Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders. NeuroImage: Clinical. ISSN 2213-1582. 15, s 719- 731 . doi: 10.1016/j.nicl.2017.06.014 Full text in Research Archive.
Dørum, Erlend Solberg; Kaufmann, Tobias; Alnæs, Dag; Andreassen, Ole Andreas; Richard, Geneviéve´; Kolskår, Knut-Kristian; Nordvik, Jan Egil & Westlye, Lars Tjelta (2017). Increased sensitivity to age-related differences in brain functional connectivity during continuous multiple object tracking compared to resting-state. NeuroImage. ISSN 1053-8119. 148, s 364- 372 . doi: 10.1016/j.neuroimage.2017.01.048
Engelstad, Katharina Nymo; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Vaskinn, Anja (2017). Body language reading of emotion in schizophrenia: associations with symptoms and functional outcome. Scandinavian Journal of Psychology. ISSN 0036-5564. 58(5), s 359- 366 . doi: 10.1111/sjop.12381
Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witoelar, Aree; Karch, Celeste M.; Schork, Andrew J.; Fan, Chun C.; Brewer, James B.; Momeni, Parastoo; Schellenberg, Gerard D.; Dillon, William P.; Sugrue, Leo P.; Hess, Christopher P.; Yokoyama, Jennifer S.; Bonham, Luke W.; Rabinovici, Gil D.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Hardy, John & Desikan, Rahul S. (2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. 88(2), s 152- 164 . doi: 10.1136/jnnp-2016-314411
Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2017). 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(11), s 2398- 2405 . doi: 10.1111/bcp.13341
Gupta, Cota Navin; Castro, Eduardo; Rachkonda, Srinivas; Van Erp, Theo G.M.; Potkin, Steven; Ford, Judith Marianne; Mathalon, Daniel H.; Lee, Hyo Jong; Mueller, Bryon A.; Greve, Douglas; Andreassen, Ole Andreas; Agartz, Ingrid; Mayer, Andrew Robert; Stephen, Julia; Jung, Rex E; Bustillo, Juan R; Calhoun, Vince D. & Turner, Jessica A. (2017). Biclustered independent component analysis for complex biomarker and subtype identification from structural magnetic resonance images in schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 8 . doi: 10.3389/fpsyt.2017.00179
Gupta, Cota Navin; Van Erp, Theo G M; Rachkonda, Srinivas; Potkin, Steven; Andreassen, Ole Andreas; Agartz, Ingrid & Turner, Jessica A (2017). Biclustered Independent Component Analysis for Complex Biomarker and Subtype Identification from Structural Magnetic Resonance Images in Schizophrenia.. Frontiers in Psychiatry. ISSN 1664-0640. . doi: 10.3389/fpsyt.2017.00179
Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis. Journal of Neurophysiology. ISSN 0022-3077. 118(1), s 114- 120 . doi: 10.1152/jn.00976.2016 Full text in Research Archive.
Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Bratlien, Unni; Barnaby, Nelson; Melle, Ingrid & Møller, Paul (2017). High levels of anomalous self-experience are associated with longer duration of untreated psychosis. Early Intervention in Psychiatry. ISSN 1751-7885. 11(2), s 133- 138 . doi: 10.1111/eip.12220 Full text in Research Archive.
Hellstrøm, Torgeir; Kaufmann, Tobias; Andelic, Nada; Søberg, Helene L.; Sigurdardottir, Solrun; Helseth, Eirik; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Predicting outcome 12 months after mild traumatic brain injury in patients admitted to a neurosurgery service. Frontiers in Neurology. ISSN 1664-2295. 8:125, s 1- 12 . doi: 10.3389/fneur.2017.00125 Full text in Research Archive.
Hellstrøm, Torgeir; Westlye, Lars Tjelta; Kaufmann, Tobias; Doan, Nhat Trung; Søberg, Helene L.; Sigurdardottir, Solrun; Nordhøy, Wibeke; Helseth, Eirik; Andreassen, Ole Andreas & Andelic, Nada (2017). White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury. Scientific Reports. ISSN 2045-2322. 7(1) . doi: 10.1038/s41598-017-13628-1 Full text in Research Archive.
Hellstrøm, Torgeir; Westlye, Lars Tjelta; Sigurdardottir, Solrun; Brunborg, Cathrine; Søberg, Helene L.; Holthe, Øyvor; SERVER, ANDRES; Lund, Martina Jonette; Andreassen, Ole Andreas & Andelic, Nada (2017). Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables. Brain Injury. ISSN 0269-9052. 31(5), s 674- 685 . doi: 10.1080/02699052.2017.1283537 Full text in Research Archive.
Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteriá, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R.K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn Kristin H.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil Nordbø; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C.M.; Lopez, Lorna M.; Luciano, Michelle; MacAre, Christine; Marquand, André F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Sämann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van Der Grond, Jeroen; Van Der Lee, Sven J.; Van Der Meer, Dennis; van Donkelaar, Marjolein M.J.; Van Eijk, Kristel R.; Van Erp, Theo G.M.; Van Rooij, Daan; Walton, Esther; Westlye, Lars Tjelta; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole Andreas; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; Van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders; Davies, Gareth E.; de Craen, Anton J.M.; de Geus, Eco J.C.; De Jager, Philip L.; de Zubicaray, Greig I.; Deary, Ian J.; Debette, Stéphanie; Decarli, Charles; Delanty, Norman; Depondt, Chantal; Destefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernandéz, Guillén; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Göring, Harald H.H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R.; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik Gunnar; Jukema, J. Wouter; Kahn, René S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nöthen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W.J.H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar Martin; Stott, David J.; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, André G.; Hernández, Maria C. Valdés; Van Der Brug, Marcel; Van Der Lugt, Aad; Van Der Wee, Nic J.A.; van Haren, Neeltje E.M.; Van 'T Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; Van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, William T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M. & Ikram, M. Arfan (2017). Novel genetic loci associated with hippocampal volume. Nature Communications. ISSN 2041-1723. 8:13624, s 1- 12 . doi: 10.1038/ncomms13624 Full text in Research Archive.
Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Full text in Research Archive.
Høyland, Anne Lise; Nærland, Terje; Engstrøm, Morten; Lydersen, Stian & Andreassen, Ole Andreas (2017). The relation between face-emotion recognition and social function in adolescents with autism spectrum disorders: A case control study. PLOS ONE. ISSN 1932-6203. 12(10), s 1- 16 . doi: 10.1371/journal.pone.0186124 Full text in Research Archive.
Høyland, Anne Lise; Øgrim, Kjell Geir; Lydersen, Stian; Hope, Sigrun; Engstrøm, Morten; Torske, Tonje; Nærland, Terje & Andreassen, Ole Andreas (2017). Event-related potentials in a cued Go-NoGo task associated with executive functions in adolescents with autism spectrum disorder; A case-control study. Frontiers in Neuroscience. ISSN 1662-4548. 11:393, s 1- 13 . doi: 10.3389/fnins.2017.00393 Full text in Research Archive.
Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample. International Journal of Molecular Sciences. ISSN 1422-0067. 18(5), s 1- 14 . doi: 10.3390/ijms18051078 Full text in Research Archive.
Jørgensen, Kjetil Nordbø; Nesvåg, Ragnar; Nerland, Stener; Mørch-Johnsen, Lynn; Westlye, Lars Tjelta; Lange, Elisabeth; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 135(2), s 117- 126 . doi: 10.1111/acps.12677
Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Doan, Nhat Trung; Kauppi, Karolina; Bettella, Francesco; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Djurovic, Srdjan; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets. NeuroImage. ISSN 1053-8119. 147, s 243- 252 . doi: 10.1016/j.neuroimage.2016.11.073
Kaufmann, Tobias; Alnæs, Dag; Doan, Nhat Trung; Brandt, Christine Lycke; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Delayed stabilization and individualization in connectome development are related to psychiatric disorders. Nature Neuroscience. ISSN 1097-6256. 20(4), s 513- 515 . doi: 10.1038/nn.4511
Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Pedersen, Geir Feigum; Bellivier, Frank; Icick, Romain; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2017). Alcohol use disorders are Associated With increased effective lability in bipolar disorder. Journal of Affective Disorders. ISSN 0165-0327. 208, s 316- 324 . doi: 10.1016/j.jad.2016.09.062
Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe D; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2017). Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets. Cell reports. ISSN 2211-1247. 21(9), s 2597- 2613 . doi: 10.1016/j.celrep.2017.11.028
Lange, Elisabeth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn; Nesvåg, Ragnar; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Osnes, Kåre; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls. Psychological Medicine. ISSN 0033-2917. 47(4), s 655- 668 . doi: 10.1017/S0033291716002920
Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco; Hugdahl, Kenneth; Espeseth, Thomas; Steen, Vidar Martin; Melle, Ingrid; Desikan, Rahul S.; Schork, Andrew J.; Thompson, Wesley Kurt; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin. ISSN 0586-7614. 43(3), s 654- 664 . doi: 10.1093/schbul/sbw085
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Lo, Min-Tzu; Wang, Yunpeng; Kauppi, Karolina; Sanyal, Nilotpal; Fan, Chun-Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew; Holland, Dominic; Hinds, David A; Tung, Joyce Y; Andreassen, Ole Andreas; Dale, Anders M & Chen, Chi-Hua (2017). Modeling prior information of common genetic variants improves gene discovery for neuroticism. Human Molecular Genetics. ISSN 0964-6906. 26(22), s 4530- 4539 . doi: 10.1093/hmg/ddx340
Lu, Y; Pouget, Jennie G.; Andreassen, Ole Andreas; Djurovic, Srdjan; Esko, Tönu; Hultman, Christina M; Metspalu, Andres; Milani, Lili; Werge, Thomas & Sullivan, Patrick F (2017). Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. Psychological Medicine. ISSN 0033-2917. 48(7), s 1201- 1208 . doi: 10.1017/S0033291717002665
Mäki-Marttunen, Tuomo; Lines, Glenn Terje; Edwards, Andrew G; Tveito, Aslak; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational psychiatry. ISSN 2158-3188. 7(5) . doi: 10.1038/s41398-017-0007-4 Full text in Research Archive.
Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fuentes Fajarado, Karin V.; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot; Alexander, Madeline; Amin, Farooq; Atkins, Joshua; Bacanu, Silviu A.; Belliveau, Richard A.; Bergen, Sarah E.; Bertalan, Marcelo; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Bulik-Sullivan, Brendan; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Cheng, Wei; Cloninger, C. Robert; Cohen, David; Cormican, Paul; Craddock, Nick; Crespo-Facorro, Benedicto; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; DeLisi, Lynn E.; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farh, Kai-How; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedman, Joseph I.; Forstner, Andreas J.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Gershon, Elliot S.; Giegling, Ina; Giusti-Rodriguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Gratten, Jacob; De Haan, Lieuwe; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Huang, Hailiang; Ikeda, Masashi; Joa, Inge; Kähler, Anna Katarina; Kahn, René S.; Kalaydjieva, Luba; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kelly, Brian J.; Kennedy, James L.; Kim, Yunjung; Knowles, James A.; Konte, Bettina; Laurent, Claudine; Lee, Phil; Lee, S. Hong; Legge, Sophie E.; Lerer, Bernard; Levy, Deborah L.; Liang, Kung-Yee; Lieberman, Jeffrey; Lonnqvist, Jouko; Loughland, Carmel M.; Magnusson, Patrik K.E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Muller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; O'Neill, F. Anthony; Van Os, Jim; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Perkins, Diana O.; Pers, Tune H.; Pietilainen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Savitz, Adam; Schall, Ulrich; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Silverman, Jeremy M.; Smoller, Jordan W.; Söderman, Erik; Spencer, Chris CA; Stahl, Eli A.; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Thirumalai, Srinivas; Tooney, Paul A.; Veijola, Juha; Visscher, Peter M.; Waddington, John; Walsh, Dermot; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wormley, Brandon K.; Wray, Naomi R.; Wu, Jing Qin; Zai, Clement C.; Adolfsson, Rolf; Andreassen, Ole Andreas; Blackwood, Douglas H.R.; Bramon, Elvira; Buxbaum, Joseph D.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Daly, Mark J.; Darvasi, Ariel; Domenici, Enrico; Esko, Tonu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik Gunnar; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Levinson, Douglas F.; Li, Qingqin S.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sklar, Pamela; St. Clair, David; Walters, James T.R.; Werge, Thomas; Sullivan, Patrick F.; O'Donovan, Michael C.; Scherer, Stephen W.; Neale, Benjamin M. & Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics. ISSN 1061-4036. 49, s 27- 35 . doi: 10.1038/ng.3725
McLaughlin, Russell L.; Schijven, Dick; Van Rheenen, Wouter; Van Eijk, Kristel R.; O'Brien, Margaret; Kahn, René S.; Ophoff, Roel A.; Goris, An; Bradley, Daniel G.; Al-Chalabi, Ammar; van den Berg, Leonard H.; Luykx, Jurjen J.; Hardiman, Orla; Veldink, Jan H.; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid & Andreassen, Ole Andreas (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications. ISSN 2041-1723. 8:14774, s 1- 12 . doi: 10.1038/ncomms14774
Mellerup, Erling; Andreassen, Ole Andreas; Bennike, Bente; Dam, H; Djurovic, Srdjan; Jorgensen, Martin Balslev; Kessing, Lars Vedel; Koefoed, Pernille; Melle, Ingrid; Mors, Ole & Moeller, GL (2017). Combinations of genetic variants associated with bipolar disorder.. PLOS ONE. ISSN 1932-6203. 12(12) . doi: 10.1371/journal.pone.0189739
Moberget, Torgeir; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Lagerberg, Trine Vik; Diedrichsen, Jörn; Schwarz, E.; Zink, M; Eisenacher, S.; Kirsch, Peter; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Pergola, G; Quarto, T; Bertolino, A; Barch, D; Meyer-Lindenberg, Andreas; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls. Molecular Psychiatry. ISSN 1359-4184. 23(6), s 1512- 1520 . doi: 10.1038/mp.2017.106
Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 136(4), s 400- 408 . doi: 10.1111/acps.12783
Nerhus, Mari; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Haram, Marit; Haatveit, Beathe Christin; Dahl, Sandra Rinne; Gurholt, Tiril Pedersen; Bjella, Thomas; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Vitamin D deficiency associated with cognitive functioning in psychotic disorders. Journal of Clinical Psychiatry. ISSN 0160-6689. 78(7), s e750- e757 . doi: 10.4088/JCP.16m10880
Nesvåg, Ragnar; Jönsson, Erik Gunnar; Bakken, Inger Johanne; Knudsen, Gun Peggy; Bjella, Thomas; Reichborn-Kjennerud, Ted; Melle, Ingrid & Andreassen, Ole Andreas (2017). The quality of severe mental disorder diagnoses in a national health registry as compared to research diagnoses based on structured interview. BMC Psychiatry. ISSN 1471-244X. 17(1) . doi: 10.1186/s12888-017-1256-8 Full text in Research Archive.
Olafsson, Sigurgeir; Olafsson, S.; Stridh, Pernilla; Stridh, P.; Bos, Steffan Daniel; Ingason, Andrés; Ingason, Andres; Euesden, J; Euesden, Jack; Sulem, Patrick; Thorleifsson, Gudmar; Gustafsson, O; Gustafsson, Omar; Geirsson, AJ; Jóhannesson, Ari J.; Geirsson, Arni J.; Thorsson, AV; Thorsson, Arni V.; Ludviksson, BR; Sigurgeirsson, Bardur; Olafsson, Elias; Jonasson, JG; Kristjansdottir, Helga; Olafsson, E; Jonasson, Jon G.; Kristjansdottir, H; Olafsson, JH; Ólafsson, Jón Hjaltalín; Orvar, KB; Benediktsson, Rafn; Bjarnason, Ragnar; Kristjansdottir, Sjofn; Gislason, Thorarin; Gislason, Thorarinn; Valdimarsson, T; Mikaelsdottir, E; Sigurdsson, S; Sigurdsson, Snaevar; Jonsson, S; Jonsson, Stefan; Rafnar, Thorunn; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Knudsen, Gun Peggy S.; Celius, Elisabeth Gulowsen; Myhr, Kjell-Morten; Gröndal, Gerdur; Steinsson, K; Steinsson, Kristjan; Valdimarsson, Helgi; Bjornsson, Sigurdur; Bjornsdottir, US; Bjornsdottir, Unnur S.; Bjornsson, Einar S.; Nilsson, Björn; Nilsson, B; Andreassen, Ole Andreas; Alfredsson, Lars; Hillert, Jan; Kockum, Ingrid; Másson, Gísli; Masson, Gisli; Thorsteinssdottir, U; Stefánsson, Kári; Gudbjartsson, Daniel F.; Stefansson, H; Hjaltason, H; Harbo, Hanne Flinstad; Olsson, T; Jonsdottir, I & Stefansson, K (2017). Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ GENOMIC MEDICINE. ISSN 2056-7944. 2 . doi: 10.1038/s41525-017-0027-2 Full text in Research Archive. Show summary
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (P = 1.6 x 10(-7), 4.3 x 10(-9)) we used primary biliary cirrhosis as a proxy-phenotype for multiple sclerosis, the idea being that variants conferring risk of primary biliary cirrhosis have a prior probability of conferring risk of multiple sclerosis. We tested 255 variants forming the primary biliary cirrhosis-polygenic risk score and found seven multiple sclerosis-associating variants not correlated with any previously established multiple sclerosis variants. Most of the variants discovered are close to or within immune-related genes. One is a low-frequency missense variant in TYK2, another is a missense variant in MTHFR that reduces the function of the encoded enzyme affecting methionine metabolism, reported to be dysregulated in multiple sclerosis brain.
Polushina, Tatiana; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri; Djurovic, Srdjan; Cichon, Sven; Hoffmann, P; Nöthen, Markus M; Steen, Vidar Martin; Andreassen, Ole Andreas & Le Hellard, Stephanie (2017). Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data. Translational psychiatry. ISSN 2158-3188. 7(12) . doi: 10.1038/s41398-017-0033-2
Quintana, Daniel; Dieset, Ingrid; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2017). Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in neuroendocrinology (Print). ISSN 0091-3022. 45, s 1- 10 . doi: 10.1016/j.yfrne.2016.12.004 Full text in Research Archive.
Quintana, Daniel; Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik Fredrik; Groote, Inge Rasmus; Kaufmann, Tobias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Diurnal Variation and twenty-four hour sleep deprivation do not alter supine heart rate variability in healthy male young adults. PLOS ONE. ISSN 1932-6203. 12:e0170921(2), s 1- 16 . doi: 10.1371/journal.pone.0170921 Full text in Research Archive.
Quintana, Daniel; Westlye, Lars Tjelta; Hope, Sigrun; Nærland, Terje; Elvsåshagen, Torbjørn; Dørum, Erlend Solberg; Rustan, Øyvind; Valstad, Mathias; Rezvaya, Liudmila; Lishaugen, Hanna; Stensønes, Elise; Yaqub, Sheraz; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2017). Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial. Translational psychiatry. ISSN 2158-3188. e1136(7), s 1- 9 . doi: 10.1038/tp.2017.103 Full text in Research Archive.
Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng & Andreassen, Ole Andreas (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567. 57(2), s 86- 95 . doi: 10.1016/j.jaac.2017.11.013 Full text in Research Archive.
Simonsen, Carmen Elisabeth; Færden, Ann; Romm, Kristin Lie; Berg, Akiah Ottesen; Bjella, Thomas; Sundet, Kjetil Søren; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up. Psychiatry Research. ISSN 0165-1781. 254, s 118- 125 . doi: 10.1016/j.psychres.2017.04.050
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Brandt, Christine Lycke; Doan, Nhat Trung; Alnæs, Dag; Tønnesen, Siren; Biele, Guido; Vaskinn, Anja; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder. Brain Imaging and Behavior. ISSN 1931-7557. . doi: 10.1007/s11682-017-9714-y
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen; Wang, Yunpeng; Krull, Florian; Bettella, Francesco; Eriksen, Jon Alm; Witoelar, Aree; Davies, Gail; Fan, Chun Chieh; Thompson, Wesley Kurt; Lam, Max; Lencz, Todd; Chen, Chi-Hua; Ueland, Torill; Jönsson, Erik Gunnar; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry. ISSN 2168-6238. 74(10), s 1065- 1075 . doi: 10.1001/jamapsychiatry.2017.1986 Full text in Research Archive.
Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin. ISSN 0586-7614. 44(4), s 854- 864 . doi: 10.1093/schbul/sbx148
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Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa; Spigset, Olav & Molden, Espen (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs. ISSN 1172-7047. 31(11), s 991- 997 . doi: 10.1007/s40263-017-0469-1
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Valstad, Mathias; Alvares, Gail A.; Egknud, Maiken; Matziorinis, Anna Maria; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2017). The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 78, s 117- 124 . doi: 10.1016/j.neubiorev.2017.04.017 Full text in Research Archive.
Vaskinn, Anja; Lagerberg, Trine Vik; Bjella, Thomas; Simonsen, Carmen Elisabeth; Andreassen, Ole Andreas; Ueland, Torill & Sundet, Kjetil Søren (2017). Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity. International journal of bipolar disorders. ISSN 2194-7511. 5(13), s 1- 9 . doi: 10.1186/s40345-017-0083-7 Full text in Research Archive.
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Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael; Thompson, Wesley Kurt; Hernandez, Dena G.; Djurovic, Srdjan; Schork, Andrew J.; Bettella, Francesco; Ellinghaus, David; Franke, Andre; Lie, Benedicte Alexandra; McEvoy, Linda K.; Karlsen, Tom Hemming; Lesage, Suzanne; Morris, Huw R.; Brice, Alexis; Wood, Nicholas W.; Heutink, Peter; Hardy, John; Singleton, Andrew B.; Dale, Anders; Gasser, Thomas; Andreassen, Ole Andreas & Sharma, Manu (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. ISSN 2168-6149. 74(7), s 780- 792 . doi: 10.1001/jamaneurol.2017.0469
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Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi; Ross, Owen A.; Rademakers, Rosa; Kim, Jungsu; Wang, Yunpeng; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Momeni, Parastoo; Sugrue, Leo P.; Hess, Christopher P.; Barkovich, A. James; Boxer, Adam L.; Seeley, William W.; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Schmansky, Nicholas J.; Fischl, Bruce; Hyman, Bradley T.; Dickson, Dennis W.; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders; Desikan, Rahul S. & Desikan, Rahul S (2017). Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. ISSN 0001-6322. 133(5), s 825- 837 . doi: 10.1007/s00401-017-1693-y
Zuber, Verena; Bettella, Francesco; Witoelar, Aree; Andreassen, Ole Andreas; Mills, Ian Geoffrey & Urbanucci, Alfonso (2017). Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. BMC Genomics. ISSN 1471-2164. 18:270, s 1- 11 . doi: 10.1186/s12864-017-3620-y Full text in Research Archive.
Aas, Monica; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Færden, Ann; Romm, Kristin Lie; Nesvåg, Ragnar; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Agartz, Ingrid & Melle, Ingrid (2016). A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. BMC Psychiatry. ISSN 1471-244X. 16 . doi: 10.1186/s12888-016-0827-4 Full text in Research Archive.
Aas, Monica; Henry, Chantal; Andreassen, Ole Andreas; Bellivier, Frank; Melle, Ingrid & Etain, Bruno (2016). The role of childhood trauma in bipolar disorders. International journal of bipolar disorders. ISSN 2194-7511. 4(2) . doi: 10.1186/s40345-015-0042-0
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Bigdeli, Tim B.; Ripke, Stephan; Bacanu, Silviu-Alin; Lee, Sang Hong; Wray, Naomi R.; Gejman, Pablo V.; Rietschel, Marcella; Cichon, Sven; St Clair, David; Corvin, Aiden; Kirov, George K.; McQuillin, Andrew; Gurling, Hugh; Rujescu, Dan; Andreassen, Ole Andreas; Werge, Thomas; Blackwood, Douglas H.R.; Pato, Carlos N.; Pato, Michele T.; Malhotra, Anil K.; O'Donovan, Michael C.; Kendler, Kenneth S. & Fanous, Ayman H. (2016). Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 171(2), s 276- 289 . doi: 10.1002/ajmg.b.32402
Bonham, Luke W.; Geier, Ethan G.; Fan, Chun C.; Leong, Josiah K.; Besser, Lilah; Kukull, Walter A.; Kornak, John; Andreassen, Ole Andreas; Schellenberg, Gerard D.; Rosen, Howard J.; Dillon, William P.; Hess, Christopher P.; Miller, Bruce L.; Dale, Anders Martin; Desikan, Rahul S. & Yokoyama, Jennifer S. (2016). Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease. Annals of clinical and translational neurology. ISSN 2328-9503. 3(9), s 668- 677 . doi: 10.1002/acn3.333
Dahl, Johan; Ormstad, Heidi Kristin; Aass, Hans Christian; Sandvik, Leiv; Malt, Ulrik Fredrik & Andreassen, Ole Andreas (2016). Recovery from major depressive disorder episode after non-pharmacological treatment is associated with normalized cytokine levels. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 134(1), s 40- 47 . doi: 10.1111/acps.12576 Show summary
Background Several lines of evidence show that the immune system is implicated in the pathophysiology of major depressive disorder (MDD) and that treatment with antidepressants affects cytokine and C-reactive protein (CRP) levels. Few studies have investigated immune markers during non-pharmacological treatment. In this follow-up study, we investigated whether CRP and elevated plasma cytokine levels observed before treatment of an acute episode of MDD are normalized during non-pharmacological treatment. Methods We obtained clinical assessments and blood for CRP and cytokine analysis from 50 unmedicated MDD patients, and cytokine levels from healthy controls. The patients received ‘therapy as usual’ for 12 weeks, and the assessments were then repeated. Of the 43 completers, 29 patients did not receive medication. Results In the patients receiving treatment without antidepressants, the depressive symptoms and the plasma levels of eight cytokines (interleukin (IL)-1Ra, IL-5,-6,-8,-10, G-CSF, IFN-γ, and TNF-α) were significantly reduced (P = 0.002–0.048). The cytokine levels were no longer different from the controls. The plasma CRP level did not change. Conclusion Cytokine plasma levels normalized during recovery from an acute depressive episode in MDD without antidepressant treatment. These findings may have implications for the understanding of the role of the immune system in depression and recovery from depression.
Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2016). History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first-treatment bipolar I disorder. Bipolar Disorders. ISSN 1398-5647. 18(2), s 136- 147 . doi: 10.1111/bdi.12377
Dieset, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2016). Somatic Comorbidity in Schizophrenia: Some Possible Biological Mechanisms Across the Life Span. Schizophrenia Bulletin. ISSN 0586-7614. 42(6), s 1316- 1319 . doi: 10.1093/schbul/sbw028
Dørum, Erlend Solberg; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Lund, Martina Jonette; Tønnesen, Siren; Sneve, Markus Handal; Mathiesen, Nina Christine; Rustan, Øyvind; Gjertsen, Øivind; Vatn, Sigurd; Fure, Brynjar; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2016). Age-related differences in brain network activation and co-activation during multiple object tracking. Brain and Behavior. ISSN 2162-3279. 6(11) . doi: 10.1002/brb3.533 Full text in Research Archive.
Ellinghaus, David; Jostins, Luke; Spain, Sarah L.; Cortes, Adrian; Bethune, Jörn; Han, Buhm; Park, Yu Rang; Raychaudhuri, Soumya; Pouget, Jennie G.; Hübenthal, Matthias; Folseraas, Trine; Wang, Yunpeng; Esko, Tõnu; Metspalu, Andres; Westra, Harm-Jan; Franke, Lude; Pers, Tune H.; Weersma, Rinse K.; Collij, Valerie; D'Amato, Mauro; Halfvarson, Jonas; Jensen, Anders Boeck; Lieb, Wolfgang; Degenhardt, Franziska A.; Forstner, Andreas J.; Hofmann, Andrea; Schreiber, Stefan; Mrowietz, Ulrich; Juran, Brian D.; Lazaridis, Konstantinos N.; Brunak, Søren; Dale, Anders M.; Trembath, Richard C.; Weidinger, Stephan; Weichenthal, Michael; Ellinghaus, Eva; Elder, James T.; Barker, Jonathan N.W.N.; Andreassen, Ole Andreas; McGovern, Dermot P.; Karlsen, Tom Hemming; Barrett, Jeffrey C.; Parkes, Miles; Brown, Matthew A. & Franke, Andre (2016). Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics. ISSN 1061-4036. 48(5), s 510- 518 . doi: 10.1038/ng.3528
Fjukstad, Katrine Kveli; Engum, Anne; Lydersen, Stian; Dieset, Ingrid; Steen, Nils Eiel; Andreassen, Ole Andreas & Spigset, Olav (2016). Metabolic abnormalities related to treatment with selective serotonin reuptake inhibitors in patients with schizophrenia or bipolar disorder.. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 36(6), s 615- 620 . doi: 10.1097/JCP.0000000000000582
Fountoulakis, Konstantinos N.; Chatzikosta, Isaia; Pastiadis, Konstantinos; Zanis, Prodromos; Kawohl, Wolfram; Kerkhof, Ad J.F.M.; Navickas, Alvydas; Höschl, Cyril; Lecic-Tosevski, Dusica; Sorel, Eliot; Rancans, Elmars; Palova, Eva; Juckel, Georg; Isacsson, Göran; Jagodic, Helena Korosec; Botezat-Antonescu, Ileana; Rybakowski, Janusz; Azorin, Jean Michel; Cookson, John; Waddington, John; Pregelj, Peter; Demyttenaere, Koen; Hranov, Luchezar G.; Stevovic, Lidija Injac; Pezawas, Lucas; Adida, Marc; Figuera, Maria Luisa; Jakovljevic, Miro; Vichi, Monica; Perugi, Giulio; Andreassen, Ole Andreas; Vukovic, Olivera; Mavrogiorgou, Paraskevi; Varnik, Peeter; Dome, Peter; Winkler, Petr; Salokangas, Raimo K.R.; From, Tiina; Danileviciute, Vita; Gonda, Xenia; Rihmer, Zoltan; Forsman, Jonas; Grady, Anne; Hyphantis, Thomas; Dieset, Ingrid; Søndergaard, Susan; Pompili, Maurizio & Bech, Per (2016). Relationship of suicide rates with climate and economic variables in Europe during 2000-2012. Annals of General Psychiatry. ISSN 1744-859X. 15:19, s 1- 6 . doi: 10.1186/s12991-016-0106-2
Franke, Barbara; Stein, Jason L.; Ripke, Stephan; Anttila, Verneri; Hibar, Derrek P.; van Hulzen, Kimm J.E.; Arias-Vasquez, Alejandro; Smoller, Jordan W.; Nichols, Thomas E.; Neale, Michael C.; McIntosh, Andrew M.; Lee, Phil; McMahon, Francis J.; Meyer-Lindenberg, Andreas; Mattheisen, Manuel; Andreassen, Ole Andreas; Gruber, Oliver; Sachdev, Perminder S.; Roiz-Santiañez, Roberto; Saykin, Andrew J.; Ehrlich, Stefan; Mather, Karen A.; Turner, Jessica A.; Schwarz, Emanuel; Thalamuthu, Anbupalam; Yao, Yin; Ho, Yvonne Y.W.; Martin, Nicholas G.; Wright, Margaret J.; O'Donovan, Michael C.; Thompson, Paul M.; Neale, Benjamin M.; Medland, Sarah E. & Sullivan, Patrick F. (2016). Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept. Nature Neuroscience. ISSN 1097-6256. 19(3), s 420- 431 . doi: 10.1038/nn.4228
Grellmann, Claudia; Neumann, Jane; Bitzer, Sebastian; Kovacs, Peter; Tönjes, Anke; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Stumvoll, Michael; Villringer, Arno & Horstmann, Annette (2016). Random Projection for fast and efficient multivariate correlation analysis of high-dimensional data: A new approach. Frontiers in Genetics. ISSN 1664-8021. 7 . doi: 10.3389/fgene.2016.00102
Guadalupe, Tulio; Mathias, Samuel R.; VanErp, Theo G.M.; Whelan, Christopher D.; Zwiers, Marcel P.; Abe, Yoshinari; Abramovic, Lucija; Agartz, Ingrid; Andreassen, Ole Andreas; Arias-Vásquez, Alejandro; Aribisala, Benjamin S.; Armstrong, Nicola J.; Arolt, Volker; Artiges, Eric; Ayesa-Arriola, Rosa; Baboyan, Vatche G.; Banaschewski, Tobias; Barker, Gareth; Bastin, Mark E.; Baune, Bernhard T.; Blangero, John; Bokde, Arun L.W.; Boedhoe, Premika S.W.; Bose, Anushree; Brem, Silvia; Brodaty, Henry; Bromberg, Uli; Brooks, Samantha; Büchel, Christian; Buitelaar, Jan; Calhoun, Vince D.; Cannon, Dara M.; Cattrell, Anna; Cheng, Yuqi; Conrod, Patricia J.; Conzelmann, Annette; Corvin, Aiden; Crespo-Facorro, Benedicto; Crivello, Fabrice; Dannlowski, Udo; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Deary, Ian J.; Desrivieres, Sylvane; Doan, Nhat Trung; Donohoe, Gary; Dørum, Erlend Solberg; Ehrlich, Stefan; Espeseth, Thomas; Fernandéz, Guillén; Flor, Herta; Fouche, Jean-Paul; Frouin, Vincent; Fukunaga, Masaki; Gallinat, Jurgen; Garavan, Hugh; Gill, Michael; Suarez, Andrea Gonzalez; Gowland, Penny; Grabe, Hans J.; Grotegerd, Dominik; Gruber, Oliver; Hagenaars, Saskia; Hashimoto, Ryota; Hauser, Tobias U.; Heinz, Andreas; Hibar, Derrek; Hoekstra, Pieter J.; Hoogman, Martine; Howells, Fleur M.; Hu, Hao; Hulshoff Pol, Hilleke E.; Huyser, Chaim; Ittermann, Bernd; Jahanshad, Neda; Jönsson, Erik Gunnar; Jurk, Sarah; Kahn, René S.; Kelly, Sinead; Kraemer, Bernd; Kugel, Harald; Kwon, Jun Soo; Lemaitre, Herve; Lesch, Klaus-Peter; Lochner, Christine; Luciano, Michelle; Marquand, André F.; Martin, Nicholas G.; Martinez-Zalacain, Ignacio; Martinot, Jean-Luc; Mataix-Cols, David; Mather, Karen; McDonald, Colm; McMahon, Katie L.; Medland, Sarah E.; Menchon, José M.; Morris, Derek W.; Mothersill, Omar; Maniega, Susana Munoz; Mwangi, Benson; Nakamae, Takashi; Nakao, Tomohiro; Narayanaswaamy, Janardhanan C.; Nees, Frauke; Nordvik, Jan Egil; Onnink, A. Marten H.; Opel, Nils; Ophoff, Roel; Paillere Martinot, Marie-Laure; Papadopoulos Orfanos, Dimitri; Pauli, Paul; Paus, Tomáš; Poustka, Luise; Reddy, Janardhan Y.C.; Renteriá, Miguel E.; Roiz-Santiañez, Roberto; Roos, Annerine; Royle, Natalie A.; Sachdev, Perminder; Sánchez-Juan, Pascual; Schmaal, Lianne; Schumann, Gunter; Shumskaya, Elena; Smolka, Michael N.; Soares, Jair C.; Soriano-Mas, Carles; Stein, Dan J.; Strike, Lachlan T.; Toro, Roberto; Turner, Jessica A.; Tzourio-Mazoyer, Nathalie; Uhlmann, Anne; Hernández, Maria Valdés; van den Heuvel, Odile A.; van der Meer, Dennis; van Haren, Neeltje E.M.; Veltman, Dick J.; Venkatasubramanian, Ganesan; Vetter, Nora C.; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wang, Zhen; Wardlaw, Joanna; Wen, Wei; Westlye, Lars Tjelta; Whelan, Robert; Wittfeld, Katharina; Wolfers, Thomas; Wright, Margaret J.; Xu, Jian; Xu, Xiufeng; Yun, Je-Yeon; Zhao, JingJing; Franke, Barbara; Thompson, Paul M.; Glahn, David C.; Mazoyer, Bernard; Fisher, Simon E. & Francks, Clyde (2016). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior. ISSN 1931-7557. Published ahead of print, s 1- 18 . doi: 10.1007/s11682-016-9629-z
Gunnarsson, Bjarni; Jonsdottir, Gudrun A; Bjornsdottir, Gyda; Konte, Bettina; Sulem, Patrick; Kristmundsdottir, Snædis; Kehr, Birte; Gustafsson, Omar; Helgason, Hannes; Iordache, Paul D; Olafsson, Sigurgeir; Frigge, Michael L; Thorleifsson, Gudmar; Arnarsdottir, Sunna; Stefansdottir, Berglind; Giegling, Ina; Djurovic, Srdjan; Sundet, Kjetil Søren; Espeseth, Thomas; Melle, Ingrid; Hartmann, Annette M.; Thorsteinsdottir, Unnur; Kong, Augustine; Gudbjartsson, Daniel F.; Ettinger, Ulrich; Andreassen, Ole Andreas; Rujescu, Dan; Halldorsson, Jonas G.; Stefansson, Hreinn; Halldorsson, Bjarni V. & Stefánsson, Kári (2016). A sequence variant associating with educational attainment also affects childhood cognition. Scientific Reports. ISSN 2045-2322. 6 . doi: 10.1038/srep36189
Haatveit, Beathe Christin; Jensen, Jimmy; Alnæs, Dag; Kaufmann, Tobias; Brandt, Christine Lycke; Thoresen, Christian; Andreassen, Ole Andreas; Melle, Ingrid; Ueland, Torill & Westlye, Lars Tjelta (2016). Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders. NeuroImage: Clinical. ISSN 2213-1582. 12, s 389- 396 . doi: 10.1016/j.nicl.2016.08.012
Halnes, Geir; Mäki-Marttunen, Tuomo; Keller, Daniel; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. PLoS Computational Biology. ISSN 1553-734X. 12(11) . doi: 10.1371/journal.pcbi.1005193 Full text in Research Archive.
Haram, Marit; Bettella, Francesco; Brandt, Christine Lycke; Quintana, Daniel; Nerhus, Mari; Bjella, Thomas; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Melle, Ingrid & Tesli, Martin Steen (2016). Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. BJPsych Open. ISSN 2056-4724. 2(6), s 353- 358 . doi: 10.1192/bjpo.bp.116.003376
Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Bratlien, Unni; Romm, Kristin Lie; Møller, Paul & Melle, Ingrid (2016). The association between anomalous self-experiences, self-esteem and depression in first episode schizophrenia. Frontiers in Human Neuroscience. ISSN 1662-5161. 10(557) . doi: 10.3389/fnhum.2016.00557
Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Møller, Paul; Melle, Ingrid; Romm, Kristin Lie & Bratlien, Unni (2016). The association between anomalous self-experiences, self-esteem and depression in first episode schizophrenia. Frontiers in Human Neuroscience. ISSN 1662-5161. Nov 7 Full text in Research Archive.
Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Nerland, Stener; Jørgensen, Kjetil Nordbø; Lange, Elisabeth; Simonsen, Carmen Elisabeth; Nesvåg, Ragnar; Dale, Anders; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2016). No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis. Psychological Medicine. ISSN 0033-2917. 46(3), s 589- 598 . doi: 10.1017/S003329171500210X Show summary
Background. First-episode psychosis (FEP) patients show structural brain abnormalities. Whether the changes are progressive or not remain under debate, and the results from longitudinal magnetic resonance imaging (MRI) studies are mixed. We investigated if FEP patients showed a different pattern of regional brain structural change over a 1-year period compared with healthy controls, and if putative changes correlated with clinical characteristics and outcome. Method. MRIs of 79 FEP patients [SCID-I-verified diagnoses: schizophrenia, psychotic bipolar disorder, or other psychoses, mean age 27.6 (S.D. = 7.7) years, 66% male] and 82 healthy controls [age 29.3 (S.D. = 7.2) years, 66% male] were acquired from the same 1.5 T scanner at baseline and 1-year follow-up as part of the Thematically Organized Psychosis (TOP) study, Oslo, Norway. Scans were automatically processed with the longitudinal stream in FreeSurfer that creates an unbiased within-subject template image. General linear models were used to analyse longitudinal change in a wide range of subcortical volumes and detailed thickness and surface area estimates across the entire cortex, and associations with clinical characteristics. Results. FEP patients and controls did not differ significantly in annual percentage change in cortical thickness or area in any cortical region, or in any of the subcortical structures after adjustment for multiple comparisons. Within the FEP group, duration of untreated psychosis, age at illness onset, antipsychotic medication use and remission at follow-up were not related to longitudinal brain change. Conclusions. We found no significant longitudinal brain changes over a 1-year period in FEP patients. Our results do not support early progressive brain changes in psychotic disorders.
Helle, Siri; Ringen, Petter Andreas; Melle, Ingrid; Larsen, Tor Ketil; Gjestad, Rolf; Johnsen, Erik; Lagerberg, Trine Vik; Andreassen, Ole Andreas; Kroken, Rune Andreas; Joa, Inge; Hegelstad, Wenche & Løberg, Else-Marie (2016). Cannabis use is associated with 3 years earlier onset of schizophrenia spectrum disorder in a naturalistic, multi-site sample (N = 1119). Schizophrenia Research. ISSN 0920-9964. 170(1), s 217- 221 . doi: 10.1016/j.schres.2015.11.027
Hellstrøm, Torgeir; Westlye, Lars Tjelta; SERVER, ANDRES; Løvstad, Marianne; Brunborg, Cathrine; Lund, Martina Jonette; Nordhøy, Wibeke; Andreassen, Ole Andreas & Andelic, Nada (2016). Volumetric and morphometric MRI findings in patients with mild traumatic brain injury. Brain Injury. ISSN 0269-9052. 30(13-14), s 1683- 1691 . doi: 10.1080/02699052.2016.1199905 Show summary
Objective: This study compared cortical and sub-cortical volumes between patients with complicated (i.e. presence of intracranial abnormality on the day-of-injury CT) and uncomplicated (i.e. absence of intracranial abnormality) mild traumatic brain injury (MTBI) 4 weeks post-injury. The study hypothesized regionally decreased brain volumes and reduced cortical thickness in patients with complicated MTBIs compared with uncomplicated MTBI. Methods: This study was part of a larger 2 years cohort study on MTBI. Baseline clinical and magnetic resonance imaging (MRI) data were compared for those with complicated and uncomplicated MTBI. It identified 168 patients with MTBI (90 uncomplicated and 78 complicated), aged 16–65 years. 3T MRI-system (Signa HDxt, GE Medical Systems, Milwaukee, WI) and cortical reconstruction and volumetric segmentation by FreeSurfer software have been used. Results: No significant differences between uncomplicated and complicated MTBIs were found in neuroanatomic volumes and cortical thickness after controlling for age, gender and education. The complicated MTBI group showed larger ventricles compared with the uncomplicated group, but this effect diluted when adjusting for potential confounders. Conclusion: The study findings suggest that the classification of complicated and uncomplicated MTBI may be too broad to differentiate volumetric and morphometric effects of injury in the early post-injury phase.
Hibar, Derrek; Westlye, Lars Tjelta; Van Erp, TGM; Rasmussen, J; Leonardo, CD; Faskowitz, J; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Doan, Nhat Trung; Agartz, Ingrid; Dale, AM; Gruber, O; Krämer, B; Trost, S; Liberg, B; Abe, C; Ekman, CJ; Ingvar, M; Landen, M; Fears, SC; Freimer, NB; Bearden, CE; Sprooten, E; Glahn, DC; Pearlson, GD; Emsell, L; Kenney, J; Scanlon, C; McDonald, C; Cannon, DM; Almeida, J; Versace, A; Caseras, X; Lawrence, NS; Phillips, ML; Dima, D; Delvecchio, G; Frangou, S; Satterthwaite, TD; Wolf, D; Houenou, J; Henry, C; Malt, Ulrik Fredrik; Bøen, Erlend; Elvsåshagen, Torbjørn; Young, AH; Lloyd, AJ; Goodwin, GM; Mackay, CE; Bourne, C; Bilderbeck, A; Abramovic, L; Boks, MP; Van Haren, NEM; Ophoff, RA; Kahn, RS; Bauer, M; Pfennig, A; Alda, M; Hajek, T; Mwangi, B; Soares, JC; Nickson, T; Dimitrova, R; Sussmann, JE; Hagenaars, S; Whalley, HC; McIntosh, AM; Thompson, PM & Andreassen, Ole Andreas (2016). Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. 21(12), s 1710- 1716 . doi: 10.1038/mp.2015.227 Show summary
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case–control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen’s d=−0.232; P=3.50 × 10−7) and thalamus (d=−0.148; P=4.27 × 10−3) and enlarged lateral ventricles (d=−0.260; P=3.93 × 10−5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.
Hoeffding, LKE; Duong, Linh; Ingason, A; Rosengren, A; Sorbanski, Ester; Witt, SH; Djurovic, Srdjan; Andreassen, Ole Andreas; Hansen, Thomas; Werge, T & Rasmussen, HB (2016). Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders. Nordic Journal of Psychiatry. ISSN 0803-9488. 70(4), s 276- 279 . doi: 10.3109/08039488.2015.1095944
Holland, Dominic; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Chen, Chi-Hua; Lo, Min-Tzu; Witoelar, Aree; Werge, Thomas; O'Donovan, Michael; Andreassen, Ole Andreas & Dale, Anders (2016). Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics. ISSN 1664-8021. 7(15) . doi: 10.3389/fgene.2016.00015
Howrigan, Dave; Simonson, M.A.; Davies, Gail; Harris, SE; Tenesa, A.; Starr, JM; Liewald, DC; Deary, IJ; McRae, A.; Wright, MJ; Montgomery, GW; Hansell, Narelle K; Martin, NG; Payton, A.; Horan, M.; Ollier, W.; Abdellaoui, A.; Boomsma, DI; Derosse, P; Knowles, Emma; Glahn, David C.; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Christoforou, Andrea; Steen, Vidar Martin; Le Hellard, Stephanie; Sundet, Kjetil Søren; Reinvang, Ivar; Espeseth, Thomas; Lundervold, Astri; Giegling, I; Konte, B; Hartmann, AM; Rujesco, D.; Roussos, P; Giakoumaki, S; Burdick, KE; Bitsios, P; Donohoe, G; Corley, Robin P; Visscher, PM; Pendleton, N.; Malhotra, AK; Neale, BM; Lencz, T & Keller, M. (2016). Genome-wide autozygosity is associated with lower general cognitive ability. Molecular Psychiatry. ISSN 1359-4184. 21(6), s 837- 843 . doi: 10.1038/mp.2015.120
Johannessen, Tor Jarle; Nærland, Terje; Bloss, Cinnamon S.; Rietschel, Marcella; Stohmaier, Jana; Gjevik, Elen; Heiberg, Arvid; Djurovic, Srdjan & Andreassen, Ole Andreas (2016). Parents' attitudes toward genetic research in autism spectrum disorder. Psychiatric Genetics. ISSN 0955-8829. 26(2), s 74- 80 . doi: 10.1097/YPG.0000000000000121
Jørgensen, Kjetil Nordbø; Nerland, Stener; Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Nesvåg, Ragnar; Mørch-Johnsen, Lynn; Haukvik, Unn Kristin H.; Melle, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Agartz, Ingrid (2016). Increased MRI-based cortical grey/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder. Psychological Medicine. ISSN 0033-2917. 46(9), s 1971- 1985 . doi: 10.1017/S0033291716000593
Kvitland, Levi Røstad; Melle, Ingrid; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Ringen, Petter Andreas (2016). Cannabis use in first-treatment bipolar I disorder: Relations to clinical characteristics. Early Intervention in Psychiatry. ISSN 1751-7885. 10(1), s 36- 44 . doi: 10.1111/eip.12138
Kvitland, Levi Røstad; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Demmo, Christine; Hellvin, Tone; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Melle, Ingrid (2016). Duration of untreated illness in first-treatment bipolar I disorder in relation to clinical outcome and cannabis use.. Psychiatry Research. ISSN 0165-1781. 246, s 762- 768 . doi: 10.1016/j.psychres.2016.07.064
Lagerberg, Trine Vik; Icick, R.; Andreassen, Ole Andreas; Ringen, Petter Andreas; Etain, B; Aas, Monica; Henry, C; Bjella, Thomas; Melle, Ingrid & Bellivier, F (2016). Cannabis use disorder is associated with greater illness severity in tobacco smoking patients with bipolar disorder. Journal of Affective Disorders. ISSN 0165-0327. 190, s 286- 293 . doi: 10.1016/j.jad.2015.10.023
Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y.; Franz, Carol E.; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Holland, Dominic; Kauppi, Karolina; Nilotpal, Sanyal; Escott-Price, Valentina; Smith, Daniel J.; O'Donovan, Michael; Stefansson, Hreinn; Bjornsdottir, Gyda; Thorgeirsson, Thorgeir E; Stefansson, Kari; McEvoy, Linda K.; Dale, Anders; Andreassen, Ole Andreas & Chen, Chi-Hua (2016). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics. ISSN 1061-4036. 49(1), s 152- 156 . doi: 10.1038/ng.3736
Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 1(1), s 49- 59 . doi: 10.1016/j.bpsc.2015.09.002 Show summary
BACKGROUND: Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cells and identified possible common alterations in behavior across SCZ-related genes. METHODS: We applied a biophysically detailed multicompartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ and used changes in neuron model parameters to represent the effects of these variants. RESULTS: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and calcium transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ-related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. CONCLUSIONS: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside the previously proposed deficits in synaptic communication and network behavior. Keywords: Biophysical modeling, Functional genomics, Genome-wide association studies, Layer V pyramidal cell, Neuron excitability, Schizophrenia
Mehta, Divya; Tropf, Felix C.; Gratten, Jacob; Bakshi, Andrew; Zhu, Zhihong; Bacanu, Silviu-Alin; Hemani, Gibran; Magnusson, Patrik K E; Barban, Nicola; Esko, Tõnu; Metspalu, Andres; Snieder, Harold; Mowry, Bryan J.; Kendler, Kenneth S.; Yang, Jian; Visscher, Peter M.; McGrath, John J.; Mills, Melinda C; Wray, Naomi R.; Lee, S Hong; Andreassen, Ole Andreas; Bramon, Elvira; Bruggeman, Richard; Buxbaum, Joseph D; Cairns, Murray J.; Cantor, Rita M; Cloninger, C Robert; Cohen, David; Crespo-Facorro, Benedicto; Darvasi, Ariel; Delisi, Lynn E.; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Escott-Price, Valentina; Freimer, Nelson B.; Georgieva, Lyudmila; de Haan, Lieuwe; Henskens, Frans A; Joa, Inge; Julià, Antonio; Khrunin, Andrey; Lerer, Bernard; Limborska, Svetlana; Loughland, Carmel M & Macek, Milan (2016). Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women. JAMA psychiatry. ISSN 2168-6238. 73(5), s 497- 505 . doi: 10.1001/jamapsychiatry.2016.0129
Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology. ISSN 0306-4530. 67, s 189- 197 . doi: 10.1016/j.psyneuen.2016.02.011
Mørch-Johnsen, Lynn; Nesvåg, Ragnar; Jørgensen, Kjetil Nordbø; Lange, Elisabeth; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Kompus, Kristiina; Westerhausen, Rene; Osnes, Kåre; Andreassen, Ole Andreas; Melle, Ingrid; Hugdahl, Kenneth & Agartz, Ingrid (2016). Auditory cortex characteristics in schizophrenia: Associations with auditory hallucinations. Schizophrenia Bulletin. ISSN 0586-7614. 43(1), s 75- 83 . doi: 10.1093/schbul/sbw130
Nerhus, Mari; Berg, Akiah Ottesen; Kvitland, Levi Røstad; Dieset, Ingrid; Hope, Sigrun; Dahl, Sandra Rinne; Weibell, Melissa Anne E.a; Romm, Kristin Lie; Færden, Ann; Andreassen, Ole Andreas & Melle, Ingrid (2016). Low vitamin D is associated with negative and depressive symptoms in psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 178(1-3), s 44- 49 . doi: 10.1016/j.schres.2016.08.024 Full text in Research Archive. Show summary
BACKGROUND: There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers. METHODS: Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes. RESULTS: Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant. CONCLUSION: There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms.
Ormstad, Heidi Kristin; Dahl, Johan; Verkerk, Robert; Andreassen, Ole Andreas & Maes, Michael (2016). Increased plasma levels of competing amino acids, rather than lowered plasma tryptophan levels, are associated with a non-response to treatment in major depression. European Neuropsychopharmacology. ISSN 0924-977X. 26(8), s 1286- 1296 . doi: 10.1016/j.euroneuro.2016.05.005 Show summary
Lowered plasma tryptophan (TRP) and TRP/competing amino acid (CAA) ratio may be involved in the pathophysiology of major depression (MDD). Increased cortisol and immune-inflammatory mediators in MDD may affect the availability of TRP to the brain. We investigated whether baseline or post-treatment TRP, CAAs and TRP/CAA ratio are associated with a treatment response in MDD and whether these effects may be mediated by cortisol or immune biomarkers. We included 50 medication-free MDD patients with a depressive episode (DSM diagnosis) and assessed symptom severity with the Inventory of Depressive Symptomatology (IDS) before and after treatment as usual for 12 weeks (endpoint). Plasma levels of TRP, CAAs, the ratio, cortisol, CRP and 6 selected cytokines were assayed. The primary outcome was a 50% reduction in the IDS, while the secondary was a remission of the depressive episode. In IDS non-responders, CAAs increased and the TRP/CAA ratio decreased, while in IDS responders CAAs decreased and the TRP/CAA ratio increased from baseline to endpoint. In patients who were still depressed at endpoint TRP and CAAs levels had increased from baseline, while in remitted patients no such effects were found. Increases in CAAs were inversely correlated with changes in interleukin-1 receptor antagonist levels. The results show that increased CAA levels from baseline to endpoint are associated with a non-response to treatment in MDD patients. This suggests that the mechanism underpinning the CAA-related treatment resistance may be related to changes in immune pathways. CAA levels and amino acid metabolism may be new drug targets in depression.
Qian, Peng; Schork, Andrew J.; Bartsch, Hauke; Lo, Min-Tzu; Panizzon, Matthew S.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Schork, Nicholas J.; Chen, Chi-Hua & Schork, Nicholas J (2016). Conservation of Distinct Genetically-Mediated Human Cortical Pattern. PLoS Genetics. ISSN 1553-7390. 12:e1006143(7) . doi: 10.1371/journal.pgen.1006143 Full text in Research Archive.
Quintana, Daniel; Elstad, Maja; Kaufmann, Tobias; Brandt, Christine Lycke; Haatveit, Beathe Christin; Haram, Marit; Nerhus, Mari; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2016). Resting-state heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls. Scientific Reports. ISSN 2045-2322. 6:37212, s 1- 8 . doi: 10.1038/srep37212 Full text in Research Archive.
Quintana, Daniel; Guastella, Adam J.; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2016). The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 21(1), s 29- 38 . doi: 10.1038/mp.2015.166
Quintana, Daniel; Outhred, Tim; Westlye, Lars Tjelta; Malhi, Gin & Andreassen, Ole Andreas (2016). The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 5(1) . doi: 10.1186/s13643-016-0386-2
Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Rustan, Øyvind; Kaufmann, Tobias; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2016). Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within- subjects randomized dose-response fMRI trial. Psychoneuroendocrinology. ISSN 0306-4530. 69, s 180- 188 . doi: 10.1016/j.psyneuen.2016.04.010 Full text in Research Archive.
Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut T.; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2016). Reliability of basal plasma vasopressin concentrations in healthy male adults. Acta Neuropsychiatrica. ISSN 0924-2708. . doi: 10.1017/neu.2016.67
Ringen, Petter Andreas; Nesvåg, Ragnar; Helle, Siri; Lagerberg, Trine Vik; Lange, Elisabeth; Løberg, Else-Marie; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2016). Premorbid cannabis use is associated with more symptoms and poorer functioning in schizophrenia spectrum disorder. Psychological Medicine. ISSN 0033-2917. 46(15), s 3127- 3136 . doi: 10.1017/S0033291716001999 Show summary
Cannabis use disorder is associated with an earlier age at onset and a more severe outcome of schizophrenia spectrum disorders. The role of cannabis use before the onset of illness (premorbid cannabis use) has not been fully investigated. We here examined how amount and type of premorbid cannabis use was associated with the later course of illness including current substance use, symptoms and level of functioning in schizophrenia spectrum disorder. We used a naturalistic sample of patients with DSM-IV schizophrenia spectrum disorders with a comprehensive history of illness and substance use. Data on premorbid substance use was obtained from comprehensive self-report. The relationship to outcome was investigated using regression models that included current substance use and premorbid functioning. Pre-schizophrenia cannabis use was significantly associated with more severe psychotic symptoms and impaired functioning. Higher levels of premorbid cannabis use were associated with higher levels of current psychotic symptoms. These associations were independent of current substance use and premorbid functioning. Early use of cannabis (age <17 years) was associated with earlier age at onset of psychosis, independently of potential confounders. Pre-psychosis cannabis use affects illness outcome in schizophrenia spectrum disorders, and is associated with lower age at onset of psychosis. These findings of independent negative effects of premorbid cannabis use in schizophrenia suggest that a limitation of the general use of cannabis may have beneficial health effects.
Schork, AJ; Wang, Yunpeng; Thompson, Kurt Wesley; Dale, AM & Andreassen, Ole Andreas (2016). New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Current Opinion in Neurobiology. ISSN 0959-4388. 36, s 89- 98 . doi: 10.1016/j.conb.2015.10.008
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Melle, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid & Westlye, Lars Tjelta (2016). Consistent functional connectivity alterations in schizophrenia spectrum disorder: a multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), s 914- 924 . doi: 10.1093/schbul/sbw145
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Tønnesen, Siren; Biele, Guido; Melle, Ingrid; Agartz, Ingrid; Alnæs, Dag; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). Global brain connectivity alterations in persons with schizophrenia and bipolar spectrum disorders. Journal of Psychiatry & Neuroscience. ISSN 1180-4882. 41(5), s 331- 341 . doi: 10.1503/jpn.150159 Full text in Research Archive.
Solberg, Dag; Bentsen, Håvard; Refsum, Helge & Andreassen, Ole Andreas (2016). Lipid profiles in schizophrenia associated with clinical traits: A five year follow-up study. BMC Psychiatry. ISSN 1471-244X. 16(1) . doi: 10.1186/s12888-016-1006-3
Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 18(6), s 471- 482 . doi: 10.1080/15622975.2016.1245441
Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Vaskinn, Anja; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders. ISSN 2194-7511. 4(24) . doi: 10.1186/s40345-016-0067-z
Steen, Vidar Martin; Skrede, Silje; Polushina, Tatiana; López, Miguel; Andreassen, Ole Andreas; Fernø, Johan & Le Hellard, Stephanie (2016). Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. ISSN 0924-977X. 27(6), s 589- 598 . doi: 10.1016/j.euroneuro.2016.07.011
Steinan, Mette Kvisten; Morken, Gunnar; Lagerberg, Trine Vik; Melle, Ingrid; Andreassen, Ole Andreas; Vaaler, Arne Einar & Scott, Jan (2016). Delayed sleep phase: An important circadian subtype of sleep disturbance in bipolar disorders. Journal of Affective Disorders. ISSN 0165-0327. 191, s 156- 163 . doi: 10.1016/j.jad.2015.11.025
Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Hoseth, Eva Zsuzsanna; Nerhus, Mari; Lagerberg, Trine Vik; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid; Dieset, Ingrid; Djurovic, Srdjan & Andreassen, Ole Andreas (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry. ISSN 0007-1250. 209(2), s 114- 120 . doi: 10.1192/bjp.bp.115.161950
Uhlirova, Hana; Kılıç, Kıvılcım; Tian, Peifang; Sakadžić, Sava; Gagnon, Louis; Thunemann, Martin; Desjardins, Michèle; Saisan, Payam A.; Nizar, Krystal; Yaseen, Mohammad A.; Hagler, Donald J.; Vandenberghe, Matthieu; Djurovic, Srdjan; Andreassen, Ole Andreas; Silva, Gabriel A.; Masliah, Eliezer; Kleinfeld, David; Vinogradov, Sergei; Buxton, Richard B.; Einevoll, Gaute; Boas, David A.; Dale, Anders & Devor, Anna (2016). The roadmap for estimation of cell-typespecific neuronal activity from noninvasive measurements. Philosophical Transactions of the Royal Society of London. Biological Sciences. ISSN 0962-8436. 371(1705) . doi: 10.1098/rstb.2015.0356
Uhlirova, Hana; Kiliç, Kivilcim; Tian, Peifang; Thunemann, Martin; Desjardins, Michèle; Saisan, Payam A.; Sakadžić, Sava; Ness, Torbjørn Vefferstad; Mateo, Celine; Cheng, Qun; Weldy, Kimberly L.; Razoux, Florence; Vandenberghe, Matthieu; Cremonesi, Jonathan A.; Ferri, Christopher G.L.; Nizar, Krystal; Sridhar, Vishnu B.; Steed, Tyler C.; Abashin, Maxim; Fainman, Yeshaiahu; Masliah, Eliezer; Djurovic, Srdjan; Andreassen, Ole Andreas; Silva, Gabriel A.; Boas, David A.; Kleinfeld, David; Buxton, Richard B.; Einevoll, Gaute; Dale, Anders & Devor, Anna (2016). Cell type specificity of neurovascular coupling in cerebral cortex. eLIFE. ISSN 2050-084X. 5:e14315(2016) . doi: 10.7554/eLife.14315 Full text in Research Archive.
Valstad, Mathias; Alvares, Gail A.; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2016). The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 5(49) . doi: 10.1186/s13643-016-0225-5 Full text in Research Archive.
Vijayaraghavan, Swetha; Darreh-Shori, Taher; Rongve, Arvid; Berge, Guro; Sando, Sigrid Botne; White, Linda; Auestad, Bjørn Henrik; Witoelar, Aree; Andreassen, Ole Andreas; Ulstein, Ingun & Aarsland, Dag (2016). Association of Butyrylcholinesterase-K allele and Apolipoprotein E ε 4 allele with cognitive decline in dementia with lewy bodies and Alzheimer's disease. Journal of Alzheimer's Disease. ISSN 1387-2877. 50(2), s 567- 576 . doi: 10.3233/JAD-150750
Wang, Yunpeng; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Thompson, Wesley K.; Schork, Andrew J.; Bettella, Francesco; Witoelar, Aree; Lie, Benedicte Alexandra; Li, Wen; McEvoy, Linda K.; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.. Multiple Sclerosis. ISSN 1352-4585. 22(14), s 1783- 1793 . doi: 10.1177/1352458516635873
Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Holland, Dominic; Chen, Chi-Hua; Bettella, Francesco; Desikan, Rahul S.; Li, Wen; Witoelar, Aree; Zuber, Verena; Devor, Anna; Nöthen, Markus M; Rietschel, Marcella; Chen, Qiang; Werge, Thomas; Cichon, Sven; Weinberger, Daniel R.; Djurovic, Srdjan; O'Donovan, Michael; Visscher, Peter M; Andreassen, Ole Andreas & Dale, Anders (2016). Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genetics. ISSN 1553-7390. . doi: 10.1371/journal.pgen.1005803 Full text in Research Archive.
Yokoyama, Jennifer S.; Wang, Yunpeng; Schork, Andrew J.; Thompson, Wesley K.; Karch, Celeste M.; Cruchaga, Carlos; McEvoy, Linda K.; Witoelar, Aree; Chen, Chi-Hua; Holland, Dominic; Brewer, James B.; Franke, Andre; Dillon, William P.; Wilson, David M.; Mukherjee, Pratik; Hess, Christopher P.; Miller, Zachary; Bonham, Luke W.; Shen, Jeffrey; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Hyman, Bradley T.; Schellenberg, Gerard D.; Karlsen, Tom Hemming; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2016). Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurology. ISSN 2168-6149. 73(6), s 691- 697 . doi: 10.1001/jamaneurol.2016.0150
Ødegaard, Ketil Joachim; Alda, Martin; Anand, Anit; Andreassen, Ole Andreas; Balaraman, Yokesh; Berrettini, Wade H.; Bhattacharjee, Abesh; Brennand, Kristen J.; Burdick, Katherine E.; Calabrese, Joseph R.; Calkin, Cynthia V.; Claasen, Ana; Coryell, William H.; Craig, David; DeModena, Anna; Frye, Mark A.; Gage, Fred H.; Gao, Keming; Garnham, Julie; Gershon, Elliot; Jakobsen, Petter; Leckband, Susan G.; McCarthy, Michael J.; McInnis, Melvin G.; Maihofer, Adam X.; Mertens, Jerome; Morken, Gunnar; Nievergelt, Caroline M.; Nurnberger, John I.; Pham, Son; Schoeyen, Helle K.; Shekhtman, Tatyana; Shilling, Paul D.; Szelinger, Szabolcs; Tarwater, Bruce; Yao, Jun; Zandi, Peter P. & Kelsoe, John R. (2016). The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. ISSN 1471-244X. 16 . doi: 10.1186/s12888-016-0732-x Full text in Research Archive.
Ødegaard, Ketil Joachim; Alda, Martin; Anand, Anit; Andreassen, Ole Andreas; Balaraman, Yokesh; Berrettini, Wade H.; Bhattacharjee, Abesh; Brennand, Kristen J.; Burdick, Katherine E.; Calabrese, Joseph R.; Calkin, Cynthia V.; Claasen, Ana; Coryell, William H.; Craig, David; DeModena, Anna; Frye, Mark A.; Gage, Fred H.; Gao, Keming; Garnham, Julie; Gershon, Elliot; Jakobsen, Petter; Leckband, Susan G.; McCarthy, Michael J.; McInnis, Melvin G.; Maihofer, Adam X.; Mertens, Jerome; Morken, Gunnar; Nievergelt, Caroline M.; Nurnberger, John I.; Pham, Son; Schøyen, Helle Kristine; Shekhtman, Tatyana; Shilling, Paul D.; Szelinger, Szabolcs; Tarwater, Bruce; Yao, Jun; Zandi, Peter P. & Kelsoe, John R. (2016). The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample. BMC Psychiatry. ISSN 1471-244X. 16(129) . doi: 10.1186/s12888-016-0732-x Full text in Research Archive.
Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Duff, Eugene; Sneve, Markus Handal; Endestad, Tor; Nordvik, Jan Egil; Andreassen, Ole Andreas; Smith, Stephen M. & Westlye, Lars Tjelta (2015). Attentional load modulates large-scale functional brain connectivity beyond the core attention networks. NeuroImage. ISSN 1053-8119. 109, s 260- 272 . doi: 10.1016/j.neuroimage.2015.01.026 Show summary
In line with the notion of a continuously active and dynamic brain, functional networks identified during rest correspond with those revealed by task-fMRI. Characterizing the dynamic cross-talk between these network nodes is key to understanding the successful implementation of effortful cognitive processing in healthy individuals and its breakdown in a variety of conditions involving aberrant brain biology and cognitive dysfunction. We employed advanced network modeling on fMRI data collected during a task involving sustained attentive tracking of objects at two load levels and during rest. Using multivariate techniques, we demonstrate that attentional load levels can be significantly discriminated, and from a resting-state condition, the accuracy approaches 100%, by means of estimates of between-node functional connectivity. Several network edges were modulated during task engagement: The dorsal attention network increased connectivity with a visual node, while decreasing connectivity with motor and sensory nodes. Also, we observed a decoupling between left and right hemisphere dorsal visual streams. These results support the notion of dynamic network reconfigurations based on attentional effort. No simple correspondence between node signal amplitude change and node connectivity modulations was found, thus network modeling provides novel information beyond what is revealed by conventional task-fMRI analysis. The current decoding of attentional states confirms that edge connectivity contains highly predictive information about the mental state of the individual, and the approach shows promise for the utilization in clinical contexts.
Alnæs, Dag; Sneve, Markus Handal; Richard, Geneviéve´; Skåtun, Kristina Cecilie; Kaufmann, Tobias; Nordvik, Jan Egil; Andreassen, Ole Andreas; Endestad, Tor; Laeng, Bruno & Westlye, Lars Tjelta (2015). Functional connectivity indicates differential roles for the intraparietal sulcus and the superior parietal lobule in multiple object tracking. NeuroImage. ISSN 1053-8119. 123, s 129- 137 . doi: 10.1016/j.neuroimage.2015.08.029
Aminoff, Sofie Ragnhild; Tesli, Martin Steen; Bettella, Franscesco; Aas, Monica; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2015). Polygenic risk scores in bipolar disorders subgroups. Journal of Affective Disorders. ISSN 0165-0327. 183, s 310- 314 . doi: 10.1016/j.jad.2015.05.021
Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte Alexandra; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE. ISSN 1932-6203. 10:e 0123057(4) . doi: 10.1371/journal.pone.0123057 Full text in Research Archive.
Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ; Mattingsdal, Morten; Zuber, Verena; Bettella, Franscesco; Ripke, S; Kelsoe, JR; Kendler, KS; O'Donovan, MC; Sklar, P; McEvoy, LK; Desikan, RS; Lie, Benedicte Alexandra; Djurovic, Srdjan & Dale, Anders M. (2015). Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry. ISSN 1359-4184. 20(2), s 207- 214 . doi: 10.1038/mp.2013.195 Full text in Research Archive.
Athanasiu, Lavinia; Smorr, Lisa-Lena H; Tesli, Martin Steen; Røssberg, Jan Ivar; Sønderby, Ida Elken; Spigset, Olav; Djurovic, Srdjan & Andreassen, Ole Andreas (2015). Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs. Journal of Psychopharmacology. ISSN 0269-8811. 29(8), s 884- 891 . doi: 10.1177/0269881115584469
Barrett, Elizabeth Ann; Mork, Erlend; Færden, Ann; Nesvåg, Ragnar; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2015). The development of insight and its relationship with suicidality over one year follow-up in patients with first episode psychosis. Schizophrenia Research. ISSN 0920-9964. 162(1-3), s 97- 102 . doi: 10.1016/j.schres.2015.01.004
Bauer, Michael; Glenn, T; Alda, M; Andreassen, Ole Andreas; Angelopoulos, E; Ardau, R; Baethge, C; Bauer, R; Bellivier, F; Belmaker, RH; Berk, M; Bjella, Thomas; Bossini, L; Bersudsky, Y; Cheung, EYW; Conell, J; Del Zompo, M; Dodd, S; Etain, B; Fagiolini, A; Frye, MA; Fountoulakis, KN; Garneau-Fournier, J; Gonzalez-Pinto, A; Harima, H; Hassel, S; Henry, C; Iacovides, A; Isometsä, ET; Kapczinski, F; Kliwicki, S; König, B; Krogh, R; Kunz, M; Lafer, B; Larsen, ER; Lewitzka, U; Lopez-Jaramillo, C; MacQueen, G; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Melle, Ingrid; Monteith, S; Morken, Gunnar; Munoz, R; Nery, FG; O'Donovan, C; Osher, Y; Pfennig, A; Quiroz, D; Ramesar, R; Rasgon, N; Reif, A; Ritter, P; Rybakowski, JK; Sagduyu, K; Scippa, AM; Severus, E; Simhandl, C; Stein, DJ; Strejilevich, S; Hatim Sulaiman, A; Suominen, K; Tagata, H; Tatebayashi, Y; Torrent, C; Vieta, E; Viswanath, B; Wanchoo, MJ; Zetin, M & Whybrow, PC (2015). Influence of birth cohort on age of onset cluster analysis in bipolar I disorder. European psychiatry. ISSN 0924-9338. 30(1), s 99- 105 . doi: 10.1016/j.eurpsy.2014.10.005
Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias; Ardau, Raffaella; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bjella, Thomas; Bossini, Letizia; Bersudsky, Yuly; Wo Cheung, Eric Yat; Conell, Jörn; Del Zompo, Maria; Dodd, Seetal; Etain, Bruno; Fagiolini, Andrea; Frye, Mark A.; Fountoulakis, Kostas N; Garneau-Fournier, Jade; Gonzalez-Pinto, Ana; Gottlieb, John F; Harima, Hirohiko; Hassel, Stefanie; Henry, Chantal; Iacovides, Apostolos; Isometsä, Erkki T.; Kapczinski, Flavio; Kliwicki, Sebastian; König, Barbara; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Larsen, Erik R.; Lewitzka, Ute; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Monteith, Scott; Morken, Gunnar; Munoz, Rodrigo; Nery, Fabiano G.; O'Donovan, Claire; Osher, Yamima; Pfennig, Andrea; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Miranda-Scippa, Angela; Severus, Emanuel; Simhandl, Christian; Stein, Dan J.; Strejilevich, Sergio; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Torrent, Carla; Vieta, Eduard; Viswanath, Biju; Wanchoo, Mihir J.; Zetin, Mark & Whybrow, Peter C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of Psychiatric Research. ISSN 0022-3956. 64, s 1- 8 . doi: 10.1016/j.jpsychires.2015.03.013
Berg, Akiah Ottesen; Aas, Monica; Larsson, Sara; Nerhus, Mari; Hauff, Edvard; Andreassen, Ole Andreas & Melle, Ingrid (2015). Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder. Psychological Medicine. ISSN 0033-2917. 45(01), s 133- 142 . doi: 10.1017/S0033291714001135 Full text in Research Archive.
Berg, Akiah Ottesen; Barrett, Elizabeth Ann; Nerhus, Mari; Buchmann, Camilla Bakkalia; Simonsen, Carmen Elisabeth; Færden, Ann; Andreassen, Ole Andreas & Melle, Ingrid (2015). Psychosis: clinical insight and beliefs in immigrants in their first episode. Early Intervention in Psychiatry. ISSN 1751-7885. 12(2), s 185- 192 . doi: 10.1111/eip.12297 Show summary
Aim: Lack of insight into illness is frequent in psychotic disorders and seen as part of their primary pathology. The recognition of symptoms as psychotic, and beliefs about treatment alternatives, is also influenced by socio-cultural factors. Here we examined clinical insight into illness and beliefs about psychosis in immigrants in their first episode of psychosis compared to a reference group. Methods: 277 first episode psychosis participants were recruited to this cross-sectional study; 40 first- and 40 second-generation immigrants from Europe, Americas and Oceania (n=37), Asia including Turkey (n=28), or Africa (n=15). The Birchwood Insight Scale was used to measure clinical insight and “The Attitudes and Beliefs about Mental Health Problems”, schizophrenia version to assess socio-cultural beliefs. Results: Immigrants did not differ from the reference sample in clinical insight. After controlling for education level first generation immigrants were less likely to recognize psychotic symptoms (OR 2.9; Wald = 8.977, df 1, p =.003) and viewed hospitalization (OR 5.2; Wald = 20.388, df 1, p =.001) and treatment by a psychiatrist (OR 4.9; Wald = 6.609, df 1, p =.01)) as less beneficial than the reference group. Immigrants from Asia held more alternative explanations (OR 0.3; Wald = 6.567, df 1, p=.010). There were significantly stronger associations between clinical insight and socio-cultural beliefs in the reference group. Conclusions: Socio-cultural beliefs about psychosis in immigrants in first episode psychosis calls for more tailored information to this group, and emphasize the importance of treatment interventions involving both a cultural and personal perspective of insight.
Bolstad, Ingeborg; Andreassen, Ole Andreas; Groote, Inge Rasmus; Haatveit, Beathe Christin; SERVER, ANDRES & Jensen, Jimmy Kristian (2015). No difference in frontal cortical activity during an executive functioning task after acute doses of aripiprazole and haloperidol. Frontiers in Human Neuroscience. ISSN 1662-5161. 9(May), s 1- 8 . doi: 10.3389/fnhum.2015.00296 Full text in Research Archive.
Bolstad, Ingeborg; Andreassen, Ole Andreas; Groote, Inge Rasmus; SERVER, ANDRES; Sjaastad, Ivar; Kapur, S & Jensen, Jimmy Kristian (2015). Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study. European Neuropsychopharmacology. ISSN 0924-977X. 25(12), s 2252- 2261 . doi: 10.1016/j.euroneuro.2015.09.016 Show summary
The atypical antipsychotic drug aripiprazole is a partial dopamine (DA) D2 receptor agonist, which differentiates it from most other antipsychotics. This study compares the brain activation characteristic produced by aripiprazole with that of haloperidol, a typical D2 receptor antagonist. Healthy participants received an acute oral dose of haloperidol, aripiprazole or placebo, and then performed an active aversive conditioning task with aversive and neutral events presented as sounds, while blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was carried out. The fMRI task, targeting the mesolimbic motivational system that is thought to be disturbed in psychosis, was based on the conditioned avoidance response (CAR) animal model – a widely used test of therapeutic potential of antipsychotic drugs. In line with the CAR animal model, the present results show that subjects given haloperidol were not able to avoid more aversive than neutral task trials, even though the response times were shorter during aversive events. In the aripiprazole and placebo groups more aversive than neutral events were avoided. Accordingly, the task-related BOLD-fMRI response in the mesolimbic motivational system was diminished in the haloperidol group compared to the placebo group, particularly in the ventral striatum, whereas the aripiprazole group showed task-related activations intermediate of the placebo and haloperidol groups. The current results show differential effects on brain function by aripiprazole and haloperidol, probably related to altered DA transmission. This supports the use of pharmacological fMRI to study antipsychotic properties in humans
Brandt, Christine Lycke; Doan, Nhat Trung; Tønnesen, Siren; Agartz, Ingrid; Hugdahl, Kenneth; Melle, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2015). Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis. NeuroImage: Clinical. ISSN 2213-1582. 9, s 253- 263 . doi: 10.1016/j.nicl.2015.08.010 Full text in Research Archive.
Brandt, Christine Lycke; Kaufmann, Tobias; Agartz, Ingrid; Hugdahl, Kenneth; Jensen, Jimmy Kristian; Ueland, Toril; Haatveit, Beathe Christin; Skåtun, Kristina Cecilie; Doan, Nhat Trung; Melle, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2015). Cognitive effort and schizophrenia modulate large-scale functional brain connectivity. Schizophrenia Bulletin. ISSN 0586-7614. 41(6), s 1360- 1369 . doi: 10.1093/schbul/sbv013
Bratlien, Unni; Øie, Merete Glenne; Haug, Elisabeth; Møller, Paul; Andreassen, Ole Andreas; Lien, Lars & Melle, Ingrid (2015). Self-reported symptoms and health service use in adolescence in persons who later develop psychotic disorders: A prospective case-control study. Early Intervention in Psychiatry. ISSN 1751-7885. 9(3), s 221- 227 . doi: 10.1111/eip.12102 Show summary
Aim To investigate self-reported psychiatric and somatic symptoms and health service use at age 16 in persons who later developed a psychotic disorder compared with a control group from the same geographical areas. Method Responses concerning psychiatric or somatic health and health service use from Norwegian youth studies in a cohort of 15- and 16-year-olds in three Norwegian counties (N = 11 101, 90% response rate) were gathered. The questionnaire responses from persons later identified with a lifetime diagnosis of DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) psychotic disorders (n = 30) (confirmed psychosis, CP) were compared with responses from the rest of the group (population control, PC) (n = 11 067). Follow-up analyses were made for cases with a confirmed onset of a psychotic disorder after the time of the survey (n = 21). Results The main significant differences between the CP and PC groups were more self-reported anxiety, depression and ‘feeling in need of treatment for eating disorders’ at age 16 in the CP group. The rate of self-reported eating disorder symptoms alone reached the level of statistical significance in the follow-up analyses. The CP group did not use available health services to a markedly greater extent than the control group. Conclusion We found that, in comparison with others, youths who were later identified with a psychotic disorder reported more symptoms at age 16.
Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas & Dale, Anders (2015). Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications. ISSN 2041-1723. 6:7549 . doi: 10.1038/ncomms8549 Full text in Research Archive.
Dahl, Johan; Andreassen, Ole Andreas; Verkerk, Robert; Malt, Ulrik Fredrik; Sandvik, Leiv; Brundin, Lena & Ormstad, Heidi Kristin (2015). Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers. Psychoneuroendocrinology. ISSN 0306-4530. 56, s 12- 22 . doi: 10.1016/j.psyneuen.2015.02.011 Show summary
Background It has been suggested that the development of depressive symptoms as a result of cytokine therapy is attributable to cytokine-induced elevated activity of the kynurenine pathway. The few studies of this mechanism in patients with common major depressive disorder (MDD) have yielded inconsistent results. The aim of the present study was to identify markers of the kynurenine pathway in a clinical MDD sample with increased cytokine levels. Methods Fifty medication-free MDD patients with a depressive episode and 34 healthy controls were included at baseline; the patients were followed for 12 weeks. Before initiating treatment, the patients were diagnosed and assessed for depressive symptoms and their blood was analyzed for tryptophan and its metabolites in the kynurenine pathway. The clinical assessments and metabolite measurements were repeated after 12 weeks of “treatment as usual”. Results We did not find significant elevation of kynurenine plasma markers in patients with a depressive episode compared to healthy controls, despite elevated cytokine levels in the patients. Clinical depression scores were significantly reduced after 12 weeks, but no significant change in the plasma kynurenine pathway plasma markers was observed. Conclusion The obtained results do not support the hypothesis that MDD depressive episodes are associated with elevated activity in the kynurenine pathway. This suggests that the pathophysiology underlying depressive episodes in common MDD differs from that of interferon induced depression. Our results warrant further study of the interplay between the kynurenine pathway and the cytokine activation patterns in these conditions.
Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas & Dale, Anders (2015). Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease. Circulation. ISSN 0009-7322. 131(23), s 2061- 2069 . doi: 10.1161/CIRCULATIONAHA.115.015489 Full text in Research Archive.
Desikan, RS; Schork, AJ; Wang, Yunpeng; Witoelar, Aree; Sharma, M; McEvoy, LK; Holland, D; Brewer, JB; Chen, CH; Thompson, WK; Harold, D; Williams, J; Owen, MJ; O'Donovan, MC; Pericak-Vance, MA; Mayeux, R; Haines, JL; Farrer, LA; Schellenberg, GD; Heutink, P; Singleton, AB; Brice, A; Wood, NW; Hardy, J; Martinez, M; Choi, SH; Destefano, A; Ikram, MA; Bis, JC; Smith, A; Fitzpatrick, AL; Launer, L; Van Duijn, C; Seshadri, S; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; Djurovic, Srdjan; Hyman, BT; Snaedal, J; Stefansson, H; Stefansson, K; Gasser, T; Andreassen, Ole Andreas & Dale, AM (2015). Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry. ISSN 1359-4184. 20(12), s 1588- 1595 . doi: 10.1038/mp.2015.6
Dieset, Ingrid; Haukvik, Unn Kristin H.; Melle, Ingrid; Røssberg, Jan Ivar; Ueland, Thor; Hope, Sigrun; Dale, Anders M.; Djurovic, Srdjan; Aukrust, Pål; Agartz, Ingrid & Andreassen, Ole Andreas (2015). Association between altered brain morphology and elevated peripheral endothelial markers — Implications for psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 161(2-3), s 222- 228 . doi: 10.1016/j.schres.2014.11.006
Fretland, Ragnhild Avdem; Andersson, Stein; Sundet, Kjetil Søren; Andreassen, Ole Andreas; Melle, Ingrid & Vaskinn, Anja (2015). Theory of mind in schizophrenia: Error types and associations with symptoms. Schizophrenia Research. ISSN 0920-9964. 162(1-3), s 42- 46 . doi: 10.1016/j.schres.2015.01.024
Gjevik, Elen; Sandstad, Berit; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Sponheim, Eili (2015). Exploring the agreement between questionnaire information and DSM-IV diagnoses of comorbid psychopathology in children with autism spectrum disorders.. Autism. ISSN 1362-3613. . doi: 10.1177/1362361314526003
Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, Andrew J.; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas & Djurovic, Srdjan (2015). MicroRNAs enrichment in GWAS of complex human phenotypes. BMC Genomics. ISSN 1471-2164. 16:304 . doi: 10.1186/s12864-015-1513-5 Full text in Research Archive.
Grellman, Claudia; Bitzer, S; Neumann, Jane; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Villringer, Arno & Horstmann, Annette (2015). Comparison of variants of canonical correlation analysis and partial least squares for combined analysis of MRI and genetic data. NeuroImage. ISSN 1053-8119. 107, s 289- 310 . doi: 10.1016/j.neuroimage.2014.12.025 Show summary
The standard analysis approach in neuroimaging genetics studies is the mass-univariate linear modeling (MULM) approach. From a statistical view, however, this approach is disadvantageous, as it is computationally intensive, cannot account for complex multivariate relationships, and has to be corrected for multiple testing. In contrast, multivariate methods offer the opportunity to include combined information from multiple variants to discover meaningful associations between genetic and brain imaging data. We assessed three multivariate techniques, partial least squares correlation (PLSC), sparse canonical correlation analysis (sparse CCA) and Bayesian inter-battery factor analysis (Bayesian IBFA), with respect to their ability to detect multivariate genotype-phenotype associations. Our goal was to systematically compare these three approaches with respect to their performance and to assess their suitability for high-dimensional and multi-collinearly dependent data as is the case in neuroimaging genetics studies. In a series of simulations using both linearly independent and multi-collinear data, we show that sparse CCA and PLSC are suitable even for very high-dimensional collinear imaging data sets. Among those two, the predictive power was higher for sparse CCA when voxel numbers were below 400 times sample size and candidate SNPs were considered. Accordingly, we recommend Sparse CCA for candidate phenotype, candidate SNP studies. When voxel numbers exceeded 500 times sample size, the predictive power was the highest for PLSC. Therefore, PLSC can be considered a promising technique for multivariate modeling of high-dimensional brain-SNP-associations. In contrast, Bayesian IBFA cannot be recommended, since additional post-processing steps were necessary to detect causal relations. To verify the applicability of sparse CCA and PLSC, we applied them to an experimental imaging genetics data set provided for us. Most importantly, application of both methods replicated the findings of this data set.
Gupta, Cota Navin; Calhoun, Vince D; Rachakonda, Srinivas; Chen, Jiayu; Patel, Veena; Liu, Jingyuan; Andreassen, Ole Andreas & Agartz, Ingrid (2015). Patterns of gray matter abnormalities in schizophrenia based on an international mega-analysis. Schizophrenia Bulletin. ISSN 0586-7614. 41(5), s 1133- 1142 . doi: 10.1093/schbul/sbu177

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Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Malt, Eva Albertsen; Melle, Ingrid & Aarsland, Dag (red.) (2018). Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. 1060 s.

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Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Tesli, Martin Steen; Corfield, Elizabeth; Andreassen, Ole Andreas; Davey-Smith, George; Reichborn-Kjennerud, Ted & Havdahl, Alexandra (2019). Early manifestations of genetic risk for neurodevelopmental disorders.
Jørgensen, Kjetil Nordbø; Nerland, Stener; Moberget, Torgeir; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Agartz, Ingrid (2019). Optimizing the T1/T2 ratio for analysis within and between subjects.
Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics. Nature Neuroscience. ISSN 1097-6256. . doi: 10.1101/609586
Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Age of First Walking in Children with Suspected or Diagnosed Autism Spectrum Disorder.
Reindal, Lise; Nærland, Terje; Weidle, Bernhard; Lydersen, Stian; Andreassen, Ole Andreas & Sund, Anne Mari (2019). Tidlig motorikk og sammenheng med grad av autismesymptomer blant norske barn utredet for mistenkt autismespekterforstyrrelse (ASF).
Tesli, Martin Steen; Corfield, Elizabeth; Zayats, Tetyana; Ask, Helga; Askeland, Ragna Bugge; Hannigan, Laurie; Robinson, Elise; Andreassen, Ole Andreas; Havdahl, Alexandra & Reichborn-Kjennerud, Ted (2019). Investigation of shared genetic risk between cardiometabolic morbidity and ADHD in a Norwegian family cohort using polygenic transmission disequilibrium test.
Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Bjella, Thomas; Aas, Monica; Djurovic, Srdjan; Bellivier, Frank; Andreassen, Ole Andreas & Melle, Ingrid (2018). Affective lability and polygenic risk in bipolar disorder.
Andreassen, Ole Andreas; Malt, Eva Albertsen; Elvsåshagen, Torbjørn; Steen, Vidar Martin & Aarsland, Dag (2018). Molekylærgenetikk og nevrologi, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.), Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. Kapittel 4. s 85 - 118
Andreassen, Ole Andreas; Malt, Eva Albertsen; Malt, Ulrik Fredrik; Aarsland, Dag & Melle, Ingrid (2018). Biopsykososial forståelsesmodell, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.), Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. Kapittel 6. s 135 - 142
Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology. ISSN 0306-5251. 84(7), s 1624- 1625 . doi: 10.1111/bcp.13606
Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research. ISSN 0920-9964. 199, s 433- 435 . doi: 10.1016/j.schres.2018.03.011
Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. ISSN 1832-4274. 21(5), s 394- 397 . doi: 10.1017/thg.2018.46
Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Johnsen, Erik; Aarsland, Dag & Malt, Eva Albertsen (2018). Psykofarmakologisk behandling av psykiske lidelser, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.), Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. Kapittel 30. s 897 - 976
Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2018). Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and intelligence.
Smoller, Jordan W.; Andreassen, Ole Andreas; Edenberg, Howard J.; Faraone, Stephen V.; Glatt, Stephen J. & Kendler, Kenneth S. (2018). Correction to: Psychiatric genetics and the structure of psychopathology. Molecular Psychiatry. ISSN 1359-4184. s 1- 1 . doi: 10.1038/s41380-018-0026-4
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research. ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012
Andreassen, Ole Andreas (2017). Diabetes and Schizophrenia-New Findings for an Old Puzzle.. American Journal of Psychiatry. ISSN 0002-953X. 174(7), s 616- 617 . doi: 10.1176/appi.ajp.2017.17040409
Andreassen, Ole Andreas (2017). Increasing support for association between immune system and severe mental illness - need to find the underlying mechanisms. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 135(2), s 95- 96 . doi: 10.1111/acps.12692
Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Jørgensen, Kjetil Nordbø; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2017). Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder.
Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute T. (2017). Extracellular diffusion can introduce errors in current source density estimates..
Halnes, Geir; Solbrå, Andreas Våvang; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas; Malthe-Sørensen, Anders & Einevoll, Gaute T. (2017). Modelling electrical and chemical dynamics in brain tissue.
Impellizzeri, Agata Antonina Rita; Szabo, Attila; Fjerdingstad, Hege Brincker; Sullivan, Gareth; Glover, Joel; Andreassen, Ole Andreas & Djurovic, Srdjan (2017). Using Stem Cells to Understand the Underlying Mechanisms of Polygenic Risk of Severe Mental Disorders.
Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y; Franz, C; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, A.; Holland, D.; Kauppi, Karolina; Sanyal, Nilotpal; Escott-Price, Valentina; Smith, DJ; O'Donovan, Michael C; Stefansson, H; Bjornsdottir, Gyda; Thorgeirsson, TE; Stefansson, K; McEvoy, LK; Dale, AM; Andreassen, Ole Andreas & Chen, CH (2017). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.. Nature Genetics. ISSN 1061-4036. 49(1), s 152- 156 . doi: 10.1038/ng.3736
Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Layer V pyramidal cells as mediators of delta oscillations: Insights from biophysically detailed modeling and connections with schizophrenia genetics..
Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Delta oscillations in schizophrenia: Insights from biophysically detailed modeling of networks of layer V pyramidal cells..
Nerland, Stener; Antosz, Anna; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn Egeland; Andreassen, Ole Andreas & Agartz, Ingrid (2017). A Manual for Classifying Anatomical Variation of Heschl's Gyrus.
Quintana, Daniel; Steen, Nils Eiel & Andreassen, Ole Andreas (2017). The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant. JAMA psychiatry. ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2017.3738
Røssberg, Jan Ivar; Andreassen, Ole Andreas & Ilner, Stein E. Opjordsmoen (2017). Medisinfrie sykehusposter – et kunnskapsløst tiltak. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(6), s 426- 427 . doi: 10.4045/tidsskr.17.0091
Røssberg, Jan Ivar; Andreassen, Ole Andreas & Ilner, Stein E. Opjordsmoen (2017). Re: Psykiatriens indre konflikter eksponert. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(9), s 594- 595 . doi: 10.4045/tidsskr.17.0288
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin; Li, Wen; Florian, Krull; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A.; Li, Wen; Krull, Florian; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
Thunemann, Martin; Ness, Torbjørn V; Kılıç, Kıvılcım; Desjardins, Michèle; Bompierre, Ségolène; Vandenberghe, Matthieu; Cheng, Qun; Weldy, Kimberly A.; Djurovic, Srdjan; Andreassen, Ole Andreas; Boas, David A.; Herzog, Herbert; Einevoll, Gaute; Dale, Anders M & Devor, Anna (2017). ACTIVATION OF CORTICAL NPY-EXPRESSING INTERNEURONS PRODUCES VASCULAR EFFECTS WITHOUT MEASURABLE LFP.
Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag; Moberget, Torgeir; Kaufmann, Tobias; Sønderby, Ida Elken; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effects of ionic diffusion on power spectra of local field potentials (LFP).
Nerland, Stener; Jørgensen, Kjetil Nordbø; Jahren, Bjørn; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2016). A Topological Characterisation of Cortical Folding in Schizophrenia and Bipolar Disorder.
Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hill, David W; Davies, Gail; Eriksen, Jon Alm; Witoelar, Aree; Bettella, Francesco; Fan, Chun Chieh; Thompson, Wesley Kurt; Chen, Chi-Hua; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2016). Schizophrenia and general cognitive function share genetic influences.
Smeland, Olav Bjerkehagen; Witoelar, Aree; Lo, Min-Tzu; Tesli, Martin Steen; Wang, Yunpeng; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and the Big Five personality traits.
Smeland, Olav Bjerkehagen; Witoelar, Aree; Wang, Yunpeng; Chen, Chi-Hua; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and brain structural volumes indicates shared molecular genetic mechanisms with potential relevance for antipsychotics.
Zuber, Verena; Marconett, Crystal; Shi, Jianxin; Hua, Xing; Wheeler, William; Yang, Chenchen; Song, Lei; Dale, Anders M.; Laplana, Marina; Risch, Angela; Witoelar, Aree; Thompson, Wesley K; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Zhou, Beiyun; Borok, Zea; van der Heijden, Henricus FM; de Graaf, Jacqueline; Swinkels, Dorine; Aben, Katja K.; McKay, James; Hung, Rayjean J.; Bikeböller, Heike; Stevens, Victoria L.; Albanes, Demetrius; Caporaso, Neil E.; Han, Younghun; Wei, Youngyue; Panadero, Maria A; Mayordomo, Jose Ignacio; Christiani, David C.; Kiemeney, Lambertus; Andreassen, Ole Andreas; Houlston, Richard; Amos, Christopher I.; Chatterjee, Nilanjan; Laird-Offringa, Ite A.; Mills, Ian Geoffrey & Landi, Maria Teresa (2016). Pleiotropic analysis of lung cancer and blood triglycerides. Journal of the National Cancer Institute. ISSN 0027-8874. 108:djv167(12), s 1- 4 . doi: 10.1093/jnci/djw167
Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Bellivier, Frank; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2015). Affective lability is Associated With Alcohol use disorders in Bipolar disorder.
Andreassen, Ole Andreas (2015). Fremtidens psykiatri.
Andreassen, Ole Andreas (2015). Gene discovery in dementia.
Andreassen, Ole Andreas (2015). Genetisk forskning, relevant for barne- og ungdomspsykiatrien.
Andreassen, Ole Andreas (2015). Hvordan bygge forskergruppe.
Andreassen, Ole Andreas (2015). Hvordan søke SFF – erfaring fra søkeprosess.
Andreassen, Ole Andreas (2015). New statistical approach to polygenic diseases and phenotypes.
Andreassen, Ole Andreas (2015). Oppdatering på psykiatrisk genetikk.
Andreassen, Ole Andreas (2015, 04. september). Oxytocin og nesespray. [TV]. TV2 God morgen Norge.
Andreassen, Ole Andreas (2015). Satsing på forskning mental helse og rus.
Andreassen, Ole Andreas (2015). Shared genetic background for psychiatric disorders.
Andreassen, Ole Andreas (2015). Translational research in bipolar disorder – update from CoE NORMENT.
Andreassen, Ole Andreas (2015). Utdannelse psykiatere, fremtidens psykiatri.
Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Correction: Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE. ISSN 1932-6203. 10(5) . doi: 10.1371/journal.pone.0128048
Einevoll, Gaute & Andreassen, Ole Andreas (2015). Kampen mot hjernesykdommer. NRK Ytring.

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Published Apr. 13, 2011 2:54 PM - Last modified Dec. 10, 2019 7:03 PM

Ole Andreassen

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