Rasmus Iversen

• Lindeman, Ida; Zhou, Chunyan; Eggesbø, Linn Margrethe; Miao, Chichau; Polak, Justyna; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Qiao, Shuo-Wang; Iversen, Rasmus & Sollid, Ludvig Magne (2021). Longevity, clonal relationship and transcriptional program of celiac disease-specific plasma cells. Journal of Experimental Medicine (JEM).  ISSN 0022-1007. . doi: 10.1084/jem.20200852
• Iversen, Rasmus & Sollid, Ludvig Magne (2020). Autoimmunity provoked by foreign antigens: In celiac disease, exogenous gluten drives T cell-B cell interactions that cause autoimmunity. Science.  ISSN 0036-8075.  368(6487), s 132- 133 . doi: 10.1126/science.aay3037 Full text in Research Archive.
• Høydahl, Lene Støkken; Richter, Lisa Maria; Frick, Rahel; Snir, Omri; Gunnarsen, Kristin Støen; Landsverk, Ole J. B.; Iversen, Rasmus; Jeliazkov, Jeliazko R.; Gray, Jeffrey J.; Bergseng, Elin; Foss, Stian; Qiao, Shuo Wang; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Jahnsen, Frode Lars; Sandlie, Inger; Sollid, Ludvig Magne & Løset, Geir Åge (2019). Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease. Gastroenterology.  ISSN 0016-5085.  156(5), s 1428- 1439.e10 . doi: 10.1053/j.gastro.2018.12.013 Full text in Research Archive.
• Iversen, Rasmus; Roy, Bishnudeo; Stamnæs, Jorunn; Høydahl, Lene Støkken; Hnida, Kathrin; Neumann, Ralf Stefan; Korponay-Szabó, Ilma R.; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne (2019). Efficient T cell–B cell collaboration guides autoantibody epitope bias and onset of celiac disease. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  116(30), s 15134- 15139 . doi: 10.1073/pnas.1901561116 Full text in Research Archive.
• Cardoso, Ines Do Rosario; Østerlund, Eva Christina; Stamnæs, Jorunn; Iversen, Rasmus; Andersen, Jan Terje; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2017). Dissecting the interaction between transglutaminase 2 and fibronectin. Amino Acids.  ISSN 0939-4451.  49(3), s 489- 500 . doi: 10.1007/s00726-016-2296-y Full text in Research Archive.
• Iversen, Rasmus; Snir, Omri; Stensland, Maria; Kroll, José E.; Steinsbø, Øyvind; Korponay-Szabó, Ilma R.; Lundin, Knut Erik Aslaksen; De Souza, Gustavo Antonio & Sollid, Ludvig Magne (2017). Strong clonal relatedness between serum and gut IgA despite different plasma cell origins. Cell reports.  ISSN 2211-1247.  20(10), s 2357- 2367 . doi: 10.1016/j.celrep.2017.08.036 Full text in Research Archive.
• Roy, Bishnudeo; Neumann, Ralf Stefan; Snir, Omri; Iversen, Rasmus; Sandve, Geir Kjetil; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne (2017). High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease. Journal of Immunology.  ISSN 0022-1767.  199((2)), s 782- 791 . doi: 10.4049/jimmunol.1700169 Full text in Research Archive.
• Hnida, Kathrin; Stamnæs, Jorunn; du Pré, Marie Fleur; Mysling, Simon; Jørgensen, Thomas J D; Sollid, Ludvig Magne & Iversen, Rasmus (2016). Epitope-dependent functional effects of celiac disease autoantibodies on transglutaminase 2. Journal of Biological Chemistry.  ISSN 0021-9258.  291(49), s 25542- 25552 . doi: 10.1074/jbc.M116.738161
• Høydahl, Lene Støkken; Nilssen, Nicolay Rustad; Gunnarsen, Kristin Støen; du Pré, Marie Fleur; Iversen, Rasmus; Roos, Norbert; Chen, Xi; Michaelsen, Terje Einar; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2016). Multivalent pIX phage display selects for distinct and improved antibody properties. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep39066 Full text in Research Archive.
• Stamnæs, Jorunn; Cardoso, Ines Do Rosario; Iversen, Rasmus & Sollid, Ludvig Magne (2016). Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain. The FEBS Journal.  ISSN 1742-464X.  283(21), s 3994- 4010 . doi: 10.1111/febs.13907
• Xi, Chien; Hnida, Kathrin; Graewert, Melissa Ann; Andersen, Jan Terje; Iversen, Rasmus; Tuukkanen, Anne; Svergun, Dmitri & Sollid, Ludvig Magne (2015). Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Journal of Biological Chemistry.  ISSN 0021-9258.  290(35), s 21365- 21375 . doi: 10.1074/jbc.M115.669895
• Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal.  ISSN 1742-464X.  s 2063- 2075 . doi: 10.1111/febs.13276
• Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal.  ISSN 1742-464X.  282(11), s 2063- 2075 . doi: 10.1111/febs.13276
• Iversen, Rasmus; Fleur du Pre, Marie; Di Niro, Roberto & Sollid, Ludvig Magne (2015). Igs as substrates for transglutaminase 2: Implications for autoantibody production in celiac disease. Journal of Immunology.  ISSN 0022-1767.  195(11), s 5159- 5168 . doi: 10.4049/jimmunol.1501363 Full text in Research Archive. Show summary

  Autoantibodies specific for the enzyme transglutaminase 2 (TG2) are a hallmark of the gluten-sensitive enteropathy celiac disease. Production of the Abs is strictly dependent on exposure to dietary gluten proteins, thus raising the question how a foreign Ag (gluten) can induce an autoimmune response. It has been suggested that TG2-reactive B cells are activated by gluten-reactive T cells following receptor-mediated uptake of TG2-gluten complexes. In this study, we propose a revised model that is based on the ability of the BCR to serve as a substrate to TG2 and become cross-linked to gluten-derived peptides. We show that TG2-specific IgD molecules are preferred in the reaction and that binding of TG2 via a common epitope targeted by cells using the IgH variable gene segment (IGHV)5-51 results in more efficient cross-linking. Based on these findings we hypothesize that IgD-expressing B cells using IGHV5-51 are preferentially activated, and we suggest that this property can explain the previously reported low number of somatic mutations as well as the overrepresentation of IGHV5-51 among TG2-specific plasma cells in the celiac lesion. The model also couples gluten peptide uptake by TG2-reactive B cells directly to peptide deamidation, which is necessary for the activation of gluten-reactive T cells. It thereby provides a link between gluten deamidation, T cell activation, and the production of TG2-specific Abs. These are all key events in the development of celiac disease, and by connecting them the model may explain why the same enzyme that catalyzes gluten deamidation is also an autoantigen, something that is hardly coincidental

• Sollid, Ludvig Magne; Iversen, Rasmus; Steinsbø, Øyvind; Qiao, Shuo Wang; Bergseng, Elin; Dørum, Siri; du Pré, Fleur; Stamnæs, Jorunn; Christophersen, Asbjørn; Cardoso, Ines Do Rosario; Hnida, Kathrin; Xi, Chien; Snir, Omri & Lundin, Knut E A (2015). Small bowel, celiac disease and adaptive immunity. Digestive Diseases.  ISSN 0257-2753.  33(2), s 115- 121 . doi: 10.1159/000369512
• Stamnæs, Jorunn; Iversen, Rasmus; Fleur du Pre, Marie; Xi, Chien & Sollid, Ludvig Magne (2015). Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization. PLOS ONE.  ISSN 1932-6203.  10:e0134922(8) . doi: 10.1371/journal.pone.0134922
• Iversen, Rasmus; Mysling, Simon; Hnida, Kathrin; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2014). Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  111(48), s 17146- 17151 . doi: 10.1073/pnas.1407457111 Full text in Research Archive.
• Iversen, Rasmus; Di Niro, Roberto; Stamnæs, Jorunn; Lundin, Knut E A; Wilson, Patric C. & Sollid, Ludvig Magne (2013). Transglutaminase 2-Specific Autoantibodies in Celiac Disease Target Clustered, N-Terminal Epitopes Not Displayed on the Surface of Cells. Journal of Immunology.  ISSN 0022-1767.  190(12), s 5981- 5991 . doi: 10.4049/jimmunol.1300183 Full text in Research Archive.
• Di Niro, Roberto; Mesin, Luka; Zheng, Nai-Ying; Stamnæs, Jorunn; Morrissey, Michael; Lee, Jane-Hwei; Huang, Min; Iversen, Rasmus; du Pré, Fleur; Qiao, Shuo Wang; Lundin, Knut E A; Wilson, Patric C. & Sollid, Ludvig Magne (2012). High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nature Medicine.  ISSN 1078-8956.  18(3), s 441- U204 . doi: 10.1038/nm.2656
• Qiao, Shuo Wang; Iversen, Rasmus; Raki, Melinda & Sollid, Ludvig Magne (2012). The adaptive immune response in celiac disease. Springer Seminars in Immunopathology.  ISSN 0344-4325.  34(4), s 523- 540 . doi: 10.1007/s00281-012-0314-z

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• Iversen, Rasmus; Amundsen, Sunniva Furre; Kleppa, Liv; du Pré, Marie Fleur; Stamnæs, Jorunn & Sollid, Ludvig Magne (2020). Evidence that pathogenic transglutaminase 2 in celiac disease derives from enterocytes. Gastroenterology.  ISSN 0016-5085.  159(2), s 788- 790 . doi: 10.1053/j.gastro.2020.04.018
• Iversen, Rasmus; Di Niro, Roberto; Wilson, Patric C. & Sollid, Ludvig Magne (2011). Mechanisms for Activation of Auto-Reactive B Cells in Response to Gluten Intake in Celiac Disease. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 354- 354

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