Robert Løvsletten Smith

Researcher - NORMENT part UiO
Image of Robert Løvsletten Smith
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Visiting address Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 Oslo
Postal address OUS, Postboks 4956 Nydalen 0424 Oslo

Photo: Kirsten Sjøwall

Professional interests

I am interested in identiying factors related to individual variability in efficacy and tolerability of psychotropic drugs including antipsychotics, antdepressants and moodestabilzers.

Also, I’m interested in implementation of these factors and optimalization of drug-related therapy in clinical practice.

Background

  • 2014 - present - My main affiliation is Senter for Psychopharmacology, Diakonhjemmet Hospital. Working as pharmacist/postdoctoral fellow/supervisior and are involved in several projects: 
    • CloZapine use and tolerability - identifying factors of treatment success (Zuccess), HSØ, co-supervisor for a PhD candidate, ongoing.
    • Identifying pharmacogenetic biomarkers of treatment resistant schizophrenia, HSØ, co-supervisor for a PHD candidate, ongoing.
    • Novel biomarkers for dose individualization and monitoring of antipsychotic drugs, HSØ, co-supervisor for a PhD candidate, ongoing.
  • 2014 - 2022 - Guest Scientist at the Department of Pharmaceutical Biosciences, University of Oslo
  • 2016 - 2020 - Finished postdoc project entitled “Schizophrenia Genetics – identifying variants associated with clozapine toxicity”, HSØ
  • 2014 - PhD in pharmacology, UiO
  • 2010 - MSc Pharm, UiO
Tags: Precision Medicine, Psychiatry, Drugs and Drug Use

Publications

  • Lenk, Hasan Çağın; Klöditz, Katharina; Johansson, Inger; Smith, Robert Løvsletten; Jukic, Marin & Molden, Espen [Show all 7 contributors for this article] (2022). The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. doi: 10.1002/cpt.2571.
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit & O'Connell, Kevin Sean [Show all 8 contributors for this article] (2022). Effects of a novel UGT2B haplotype and UGT1A4*3 allele variants on glucuronidation of clozapine in vivo. Current drug metabolism. ISSN 1389-2002. 23(1), p. 66–72. doi: 10.2174/1389200223666220201152953.
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kyllesø, Lennart; Tran, Thu Thuy Anh; Tveito, Marit & Molden, Espen (2022). Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(1), p. 43–50. doi: 10.1097/JCP.0000000000001507.
  • de Leon, Leon; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Show all 104 contributors for this article] (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry. ISSN 0176-3679. p. 1–14. doi: 10.1055/a-1625-6388.
  • Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi; Seppälä, Niko & Kopeček, Miloslav [Show all 13 contributors for this article] (2021). European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(2), p. 140–147. doi: 10.1097/JCP.0000000000001341.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), p. 750–758. doi: 10.1002/cpt.2246.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, p. 999–1008. doi: 10.1007/s40263-021-00847-4. Full text in Research Archive
  • Frederiksen, Trine; Smith, Robert L.; Wollmann, Birgit Malene Tovik; Areberg, Johan & Molden, Espen (2021). Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-021-01029-7.
  • Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77(9), p. 1201–1208. doi: 10.1007/s00228-021-03114-z.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, p. 590–596. doi: 10.1016/j.schres.2020.11.025.
  • Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), p. 1–10. doi: 10.1038/s41398-020-00888-1. Full text in Research Archive
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen & Høiseth, Gudrun (2020). Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77, p. 215–221. doi: 10.1007/s00228-020-03002-y. Full text in Research Archive
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Full text in Research Archive
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Show all 7 contributors for this article] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, p. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
  • Tveito, Marit; Molden, Espen; Høiseth, Gudrun; Correll, Christoph U. & Smith, Robert Løvsletten (2019). Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, p. 41–49. doi: 10.1007/s00228-019-02768-0.
  • Tveito, Marit; Handal, Marte; Engedal, Knut; Smith, Robert Løvsletten; Høiseth, Gudrun & Skurtveit, Svetlana (2019). Forskrivning av antipsykotika til hjemmeboende eldre 2006–18. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(16), p. 1554–1558. doi: 10.4045/tidsskr.19.0233.
  • Tveito, Marit; Smith, Robert Løvsletten; Høiseth, Gudrun & Molden, Espen (2019). The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 39(6), p. 561–566. doi: 10.1097/JCP.0000000000001126.
  • Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), p. 503–508. doi: 10.1097/FTD.0000000000000619.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), p. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(5), p. 567–571. doi: 10.1097/FTD.0000000000000540.
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge & Hartberg, Cecilie Bhandari [Show all 8 contributors for this article] (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 38(6), p. 570–576. doi: 10.1097/JCP.0000000000000961.
  • Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa & Spigset, Olav [Show all 7 contributors for this article] (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs. ISSN 1172-7047. 31(11), p. 991–997. doi: 10.1007/s40263-017-0469-1.
  • Smith, Robert Løvsletten; Haslemo, Tore; Refsum, Helge & Molden, Espen (2016). Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data. European Journal of Clinical Pharmacology. ISSN 0031-6970. 72(9), p. 1099–1104. doi: 10.1007/s00228-016-2087-0.
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. Biological chemistry. ISSN 1431-6730. 396(1), p. 71–80. doi: 10.1515/hsz-2014-0172.
  • Fismen, Anne-Siri; Smith, Robert; Torsheim, Torbjørn & Samdal, Oddrun (2014). A school based study of time trends in food habits and their relation to socio-economic status among Norwegian adolescents, 2001–2009. International Journal of Behavioral Nutrition and Physical Activity. ISSN 1479-5868. 11. doi: 10.1186/s12966-014-0115-y. Full text in Research Archive
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Atorvastatin inhibits processing, activity and secretion of legumain in macrophages. Biological chemistry. ISSN 1431-6730. 396(1), p. 71–80. doi: 10.1515/hsz-2014-0172.
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar & Solberg, Rigmor [Show all 8 contributors for this article] (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 22(13), p. 3309–3315. doi: 10.1016/j.bmc.2014.04.056.
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Show all 7 contributors for this article] (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLOS ONE. ISSN 1932-6203. 9(1:85721). doi: 10.1371/journal.pone.0085721.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Haugen, Mads Haugland; Pettersen, Solveig & Mælandsmo, Gunhild [Show all 8 contributors for this article] (2012). Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie. ISSN 0300-9084. 94(12), p. 2590–2599. doi: 10.1016/j.biochi.2012.07.026.
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Smith, Robert; Ravna, aina westrheim; Sylte, Ingebrigt & Rustan, Arild [Show all 8 contributors for this article] (2012). The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 128, p. 154–164. doi: 10.1016/j.jsbmb.2011.10.006.

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  • de Leon, Jose; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Show all 104 contributors for this article] (2022). Erratum: Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (Pharmacopsychiatry (2022) 55 2 (73-86)). Pharmacopsychiatry. ISSN 0176-3679. 55(2). doi: 10.1055/a-1737-1527.
  • Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole [Show all 7 contributors for this article] (2020). Correction: Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits (Translational Psychiatry, (2020), 10, 1, (198), 10.1038/s41398-020-00888-1). Translational Psychiatry. ISSN 2158-3188. 10(1). doi: 10.1038/s41398-020-01061-4.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Show all 7 contributors for this article] (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor (2013). Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
  • Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert (2013). Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde & Solberg, Rigmor [Show all 7 contributors for this article] (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor (2013). The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
  • Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2013). Regulering av legumain i samspillet mellom makrofager og kreftceller.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig [Show all 9 contributors for this article] (2012). SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
  • Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?
  • Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Effects of atorvastatin on regulation of protease activities in macrophages.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig J. [Show all 7 contributors for this article] (2011). SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
  • Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor (2011). ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
  • Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2011). Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
  • Smith, Robert; carm, ellen; Nagel, Tove & Wikan, Gerd (2008). Report to Norad from an expert group on teacher education. NORAD.

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Published Feb. 3, 2022 2:26 PM - Last modified Mar. 17, 2022 10:41 AM

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