Torgeir Bruun Wyller

• Wang-Hansen, Marte Sofie; Kersten, Hege; Saltyte Benth, Jurate & Wyller, Torgeir Bruun (2022). The association between geriatric treatment and 30-day readmission risk among medical inpatients aged ≥75 years with multimorbidity . PLOS ONE. ISSN 1932-6203. 17(1). doi: 10.1371/journal.pone.0262340.
• Krogseth, Maria; Rostoft, Siri ; Saltyte Benth, Jurate; Selbæk, Geir & Wyller, Torgeir Bruun (2021). Skrøpelighet blant eldre pasienter med hjemmesykepleie. Tidsskrift for Den norske legeforening. ISSN 0029-2001. p. 1–10. doi: 10.4045/tidsskr.20.0688. Full text in Research Archive
• Wyller, Torgeir Bruun; Kittang, Bård Reiakvam; Ranhoff, Anette Hylen; Harg, Pernille & Myrstad, Marius (2021). Dødsfall i sykehjem etter covid-19-vaksine. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(10), p. 1–8. doi: 10.4045/tidsskr.21.0383. Full text in Research Archive
• SCHELLHORN, TILL; Aamodt, Eva Birgitte; Lydersen, Stian; Aam, Stina; Wyller, Torgeir Bruun & Saltvedt, Ingvild [Show all 7 contributors for this article] (2021). Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study. BMC Neurology. ISSN 1471-2377. 21(1), p. 1–11. doi: 10.1186/s12883-021-02117-8. Full text in Research Archive
• Engvig, Andreas; Wyller, Torgeir Bruun; Skovlund, Eva; Ahmed, Marc Vali; Hall, Trygve Sundby & Rockwood, Kenneth [Show all 8 contributors for this article] (2021). Association between clinical frailty, illness severity and post-discharge survival: a prospective cohort study of older medical inpatients in Norway. European Geriatric Medicine. ISSN 1878-7649. p. 1–9. doi: 10.1007/s41999-021-00555-8. Full text in Research Archive
• Schellhorn, Till; Zucknick, Manuela; Askim, Torunn; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege & Seljeseth, Yngve Müller [Show all 13 contributors for this article] (2021). Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatrics. ISSN 1471-2318. 21, p. 1–10. doi: 10.1186/s12877-021-02327-2. Full text in Research Archive
• Ernst, Gernot Walter; Watne, Leiv Otto; Frihagen, Frede ; Wyller, Torgeir Bruun; Dominik, Andreas & Rostrup, Morten (2021). Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 8, p. 1–8. doi: 10.3389/fcvm.2021.640970.
• Vlachos, Georgios; Ihle-Hansen, Hege; Wyller, Torgeir Bruun; Brækhus, Anne; Mangset, Margrete & Hamre, Sophia Charlotta [Show all 7 contributors for this article] (2021). Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments. Journal of Rehabilitation Medicine. ISSN 1650-1977. 53:jrm00135, p. 1–7. doi: 10.2340/16501977-2764. Full text in Research Archive
• Dakhil, Shams; Thingstad, Pernille; Frihagen, Frede ; Johnsen, Lars Gunnar; Lydersen, Stian & Skovlund, Eva [Show all 10 contributors for this article] (2021). Orthogeriatrics prevents functional decline in hip fracture patients: report from two randomized controlled trials. BMC Geriatrics. ISSN 1471-2318. 21(208). doi: 10.1186/s12877-021-02152-7. Full text in Research Archive
• Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Wyller, Torgeir Bruun; Kristoffersen, Espen Saxhaug & Lundqvist, Anders Christofer (2021). The patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medications. Aging Clinical and Experimental Research. ISSN 1594-0667. 33, p. 2857–2864. doi: 10.1007/s40520-021-01791-5. Full text in Research Archive
• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege & Vlachos, Georgios [Show all 8 contributors for this article] (2021). Factors Associated with Level of Physical Activity After Minor Stroke. Journal of Stroke & Cerebrovascular Diseases. ISSN 1052-3057. 30(4). doi: 10.1016/j.jstrokecerebrovasdis.2021.105628. Full text in Research Archive
• Hamre, Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir B.; Ihle-Hansen, Hege & Vlachos, Georgios [Show all 8 contributors for this article] (2021). Balance and gait after first minor ischemic stroke in people 70 years of age or younger: A prospective observational cohort study. Physical Therapy. ISSN 0031-9023. 100(5), p. 798–806. doi: 10.1093/PTJ/PZAA010. Full text in Research Archive
• Mehlum, Maria Hollund; Liestøl, Knut; Kjeldsen, Sverre; Wyller, Torgeir Bruun; Julius, Stevo & Rothwell, Peter M. [Show all 10 contributors for this article] (2020). Blood pressure-lowering profiles and clinical effects of angiotensin receptor blockers versus calcium channel blockers. Hypertension. ISSN 0194-911X. 75(6), p. 1584–1592. doi: 10.1161/HYPERTENSIONAHA.119.14443.
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Wyller, Torgeir Bruun; Pendlebury, Sarah T. & Lydersen, Stian [Show all 7 contributors for this article] (2020). Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder. Stroke. ISSN 0039-2499. 52(1), p. 317–320. doi: 10.1161/STROKEAHA.120.031030. Full text in Research Archive
• Kjeldsen, Sverre; Halvorsen, Sigrun; Wyller, Torgeir Bruun; Bath, Philip M. & Sandercock, Peter (2020). Eivind Berge, MD, PhD, 1964-2020: Cardiologist Who Was Fighting Stroke. Stroke. ISSN 0039-2499. 51(5), p. 1353–1355. doi: 10.1161/STROKEAHA.120.029351.
• Wyller, Torgeir Bruun (2020). «Hvileskjær» i pandemien må brukes til bedre planlegging for de eldste. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(8), p. 1–4. doi: 10.4045/tidsskr.20.0325.
• Munthe-Kaas, Ragnhild; Aam, Stina; Ihle-Hansen, Hege; Lydersen, Stian; Knapskog, Anne Brita & Wyller, Torgeir Bruun [Show all 15 contributors for this article] (2020). Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study. Alzheimer's and Dementia: Translational Research and Clinical Interventions. ISSN 2352-8737. 6:e12000(1), p. 1–9. doi: 10.1002/trc2.12000. Full text in Research Archive
• Sajjad, Muhammad Umar; Blennow, Kaj; Knapskog, Anne Brita; Idland, Ane-Victoria; Chaudhry, Farrukh Abbas & Wyller, Torgeir Bruun [Show all 8 contributors for this article] (2020). Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients. Journal of Alzheimer's Disease. ISSN 1387-2877. 73(4), p. 1363–1372. doi: 10.3233/JAD-190941. Full text in Research Archive
• Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege & Molden, Espen (2020). Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging. ISSN 1170-229X. 37(6), p. 425–433. doi: 10.1007/s40266-020-00763-0. Full text in Research Archive Show summary

  Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs in relation to pharmacogenetic variability in CYP2D6 metabolism among patients aged ≥ 70 years exposed to polypharmacy. Materials and methods: We included 173 patients with detailed information about drug use. The patients were retrospectively subjected to CYP2D6 genotyping, which comprised the most common variant alleles encoding reduced, absent, or increased CYP2D6 metabolism. In order to compare dosages across different CYP2D6-metabolized drugs, all prescribed daily doses were harmonized to the 'percent of a daily defined dose' (DDD). The mean harmonized DDD was compared between genotype-predicted normal metabolizers (NMs) and patients with reduced or absent CYP2D6 enzyme activity, defined as intermediate or poor metabolizers (IMs/PMs). Blood pressure, pulse, and patient proportions with orthostatism and bradycardia were also compared between genotype subgroups. Results: The genotype-predicted phenotype subgroups comprised 79 NMs (45.7%), 75 IMs (43.4%), and 16 PMs (9.2%). There were no differences in dosing of CYP2D6 substrates between NMs and IMs/PMs (p = 0.76). A higher proportion of CYP2D6 IMs/PMs experienced orthostatism (p = 0.03), while there were no significant subgroup differences for the other hemodynamic variables. Conclusion: In this real-life clinical setting of patients aged ≥ 70 years, dosing of CYP2D6 substrates were not adjusted according to genotype-predicted CYP2D6 metabolism. The increased occurrence of orthostatism in patients with reduced/absent CYP2D6 metabolism may indicate that individualized dosing based on genotype has the potential to prevent adverse effects in these vulnerable patients.

• Hagberg, Guri; Ihle-Hansen, Hege; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon & Øksengård, Anne Rita [Show all 11 contributors for this article] (2020). No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - A seven-year follow-up study. BMC Neurology. ISSN 1471-2377. 20, p. 1–11. doi: 10.1186/s12883-020-01753-w. Full text in Research Archive
• Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv; Brækhus, Anne; Hansson, Oskar & Blennow, Kaj [Show all 11 contributors for this article] (2020). Biomarker Profiling Beyond Amyloid and Tau: Cerebrospinal Fluid Markers, Hippocampal Atrophy, and Memory Change in Cognitively Unimpaired Older Adults. Neurobiology of Aging. ISSN 0197-4580. 93, p. 1–15. doi: 10.1016/j.neurobiolaging.2020.04.002. Full text in Research Archive
• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege & Vlachos, Georgios [Show all 8 contributors for this article] (2020). Impairments in spatial navigation during walking in patients 70 years or younger with mild stroke. Topics in Stroke Rehabilitation. ISSN 1074-9357. 27, p. 601–609. doi: 10.1080/10749357.2020.1755814. Full text in Research Archive
• Halaas, Nathalie Bodd; Henjum, Kristi; Blennow, Kaj; Dakhil, Shams; Idland, Ane-Victoria & Nilsson, Lars [Show all 13 contributors for this article] (2019). CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral Cortex. ISSN 1047-3211. 00, p. 1–12. doi: 10.1093/cercor/bhz240. Full text in Research Archive
• Næss, Gro; Wyller, Torgeir Bruun & Kirkevold, Marit (2019). Structured follow-up of frail home-dwelling older people in primary health care: Is there a special need, and could a checklist be of any benefit? A qualitative study of experiences from registered nurses and their leaders. Journal of Multidisciplinary Healthcare. ISSN 1178-2390. 12, p. 675–690. doi: 10.2147/JMDH.S212283. Full text in Research Archive
• Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege & Pitkala, Kaisu H [Show all 8 contributors for this article] (2019). Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial. JAMA Internal Medicine. ISSN 2168-6106. doi: 10.1001/jamainternmed.2019.5096. Full text in Research Archive
• Hagberg, Guri; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita & Nygård, Ståle [Show all 10 contributors for this article] (2019). Predictors for Favorable Cognitive Outcome Post-Stroke: A-Seven-Year Follow-Up Study. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. p. 1–11. doi: 10.1159/000501850.
• Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri & Bergh, Sverre [Show all 13 contributors for this article] (2019). Modifiable factors affecting older patients' quality of life and physical function during cancer treatment. Journal of Geriatric Oncology. ISSN 1879-4068. 10(6), p. 904–912. doi: 10.1016/j.jgo.2019.08.001. Full text in Research Archive
• Evensen, Sigurd Storhaug; Bourke, Alan; Lydersen, Stian; Sletvold, Olav; Saltvedt, Ingvild & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2019). Motor activity across delirium motor subtypes in geriatric patients assessed using body-worn sensors: a Norwegian cross-sectional study. BMJ Open. ISSN 2044-6055. 9:e026401(2), p. 1–7. doi: 10.1136/bmjopen-2018-026401. Full text in Research Archive
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate & Kersten, Hege (2019). Quality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter. PLOS ONE. ISSN 1932-6203. 14(7). doi: 10.1371/journal.pone.0219859. Full text in Research Archive
• Hov, Karen Roksund; Neerland, Bjørn Erik; Undseth, Øystein; Wyller, Vegard Bruun Bratholm; MacLullich, Alasdair M.J. & Qvigstad, Eirik [Show all 8 contributors for this article] (2019). The Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial. International Journal of Geriatric Psychiatry. ISSN 0885-6230. 34(7), p. 974–981. doi: 10.1002/gps.5098. Full text in Research Archive
• Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin & Sletvold, Olav (2019). Delirium motor subtypes and prognosis in hospitalized geriatric patients ? A prospective observational study. Journal of Psychosomatic Research. ISSN 0022-3999. 122, p. 24–28. doi: 10.1016/j.jpsychores.2019.04.020. Full text in Research Archive
• Hagberg, Guri; Fure, Brynjar; Sandset, Else Charlotte; Thommessen, Bente; Ihle-Hansen, Håkon & Øksengård, Anne Rita [Show all 9 contributors for this article] (2019). Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: Secondary analysis of a randomized controlled trial, a 7-year follow-up study. Vascular Health and Risk Management. ISSN 1176-6344. 15, p. 11–18. doi: 10.2147/VHRM.S191873. Full text in Research Archive
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate & Bruvik, Frøydis Kristine [Show all 7 contributors for this article] (2019). Quality of life of family carers of persons with young-onset compared to late-onset dementia. Aging & Mental Health. ISSN 1360-7863. 24(9), p. 1394–1401. doi: 10.1080/13607863.2019.1617245. Full text in Research Archive
• Neerland, Bjørn Erik; Wyller, Torgeir Bruun & Wyller, Vegard Bruun Bratholm (2019). Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses. BMC Geriatrics. ISSN 1471-2318. 19(23), p. 1–8. doi: 10.1186/s12877-019-1035-0. Full text in Research Archive
• Mehlum, Maria Hollund; Liestøl, Knut; Wyller, Torgeir Bruun; Hua, Tsushung A.; Rostrup, Morten & Berge, Eivind (2019). Blood pressure variability in hypertensive patients with atrial fibrillation in the VALUE trial. Blood Pressure. ISSN 0803-7051. 28(2), p. 77–83. doi: 10.1080/08037051.2018.1524707.
• Kirkhus, Lene; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri & Harneshaug, Magnus [Show all 9 contributors for this article] (2019). Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study. Palliative Medicine. ISSN 0269-2163. 33(3), p. 312–322. doi: 10.1177/0269216319825972. Full text in Research Archive
• Wang-Hansen, Marte Sofie; Wyller, Torgeir Bruun; Hvidsten, Lara H. Thomasgaard & Kersten, Hege (2019). Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events? European Journal of Clinical Pharmacology. ISSN 0031-6970. 75(5), p. 627–637. doi: 10.1007/s00228-019-02624-1. Full text in Research Archive
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate & Kersten, Hege (2019). Quality of Life in People with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter Study. Journal of Alzheimer's Disease. ISSN 1387-2877. 67(1), p. 197–210. doi: 10.3233/JAD-180479. Full text in Research Archive
• Halaas, Nathalie Bodd; Blennow, Kaj; Idland, Ane-Victoria; Wyller, Torgeir Bruun; Ræder, Johan & Frihagen, Frede Jon [Show all 9 contributors for this article] (2018). Neurofilament light in serum and cerebrospinal fluid of hip fracture patients with delirium. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. 46(5-6), p. 346–357. doi: 10.1159/000494754. Full text in Research Archive
• Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin & Sletvold, Olav (2018). Environmental factors and risk of delirium in geriatric patients: An observational study. BMC Geriatrics. ISSN 1471-2318. 18(1). doi: 10.1186/s12877-018-0977-y. Full text in Research Archive
• Hall, Roanna J.; Watne, Leiv; Cunningham, Emma; Zetterberg, Henrik; Shenkin, Susan D & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2018). CSF biomarkers in delirium: a systematic review. International Journal of Geriatric Psychiatry. ISSN 0885-6230. 33(11), p. 1479–1500. doi: 10.1002/gps.4720.
• Torbergsen, Anne Cathrine; Watne, Leiv; Frihagen, Frede Jon; Wyller, Torgeir Bruun & Mowe, Morten (2018). Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial. Clinical Nutrition ESPEN. ISSN 2405-4577. doi: 10.1016/j.clnesp.2017.11.012.
• Hassel, Bjørnar; Mariussen, Espen; Idland, Ane-Victoria; Dahl, Gry Torsæter; Ræder, Johan & Frihagen, Frede Jon [Show all 10 contributors for this article] (2018). CSF sodium at toxic levels precedes delirium in hip fracture patients. Neurotoxicology. ISSN 0161-813X. 69(December), p. 11–16. doi: 10.1016/j.neuro.2018.08.010.
• Ommundsen, Nina; Nesbakken, Arild; Wyller, Torgeir Bruun; Skovlund, Eva; Bakka, Arne Olav & Jordhøy, Marit Slaaen [Show all 7 contributors for this article] (2018). Post-discharge complications in frail older patients after surgery for colorectal cancer. European Journal of Surgical Oncology. ISSN 0748-7983. 44(10), p. 1542–1547. doi: 10.1016/j.ejso.2018.06.024. Full text in Research Archive
• Watne, Leiv Otto & Wyller, Torgeir Bruun (2018). Delirium - framleis underdiagnostisert. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(5). doi: 10.4045/tidsskr.18.0118.
• Hov, Karen Roksund; Neerland, Bjørn Erik; Andersen, Anders Mikal; Undseth, Øystein; Wyller, Vegard Bruun Bratholm & MacLullich, Alasdair M.J. [Show all 9 contributors for this article] (2018). The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. BMC Pharmacology & Toxicology. ISSN 2050-6511. 19(29). doi: 10.1186/s40360-018-0218-1. Full text in Research Archive
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Bruvik, Frøydis Kristine & Kersten, Hege (2018). Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. 45(1-2), p. 91–104. doi: 10.1159/000487263.
• Kirkevold, Marit; Bragstad, Line Kildal; Bronken, Berit Arnesveen; Kvigne, Kari Johanne; Martinsen, Randi & Hjelle, Ellen Gabrielsen [Show all 13 contributors for this article] (2018). Promoting psychosocial well-being following stroke: study protocol for a randomized, controlled trial. BMC Psychology. ISSN 2050-7283. 6(12). doi: 10.1186/s40359-018-0223-6. Full text in Research Archive Show summary

  Background: Stroke is a major public health threat globally. Psychosocial well-being may be affected following stroke. Depressive symptoms, anxiety, general psychological distress and social isolation are prevalent. Approximately one third report depressive symptoms and 20% report anxiety during the first months or years after the stroke. Psychosocial difficulties may impact significantly on long-term functioning and quality of life, reduce the effects of rehabilitation services and lead to higher mortality rates. The aim of the study is to evaluate the effect of a previously developed and feasibility tested dialogue-based psychosocial intervention aimed at promoting psychosocial well-being and coping following stroke among stroke survivors with and without aphasia. Methods: The study will be conducted as a multicenter, randomized, single blind controlled trial with one intervention and one control arm. It will include a total of 330 stroke survivors randomly allocated into either an intervention group (dialogue-based intervention to promote psychosocial well-being) or a control group (usual care). Participants in the intervention group will receive eight individual sessions of supported dialogues in their homes during the first six months following an acute stroke. The primary outcome measure will be psychosocial well-being measured by the General Health Questionnaire (GHQ). Secondary outcome measures will be quality of life (SAQoL), sense of coherence (SOC), and depression (Yale). Process evaluation will be conducted in a longitudinal mixed methods study by individual qualitative interviews with 15–20 participants in the intervention and control groups, focus group interviews with the intervention personnel and data collectors, and a comprehensive analysis of implementation fidelity. Discussion: The intervention described in this study protocol is based on thorough development and feasibility work, guided by the UK medical research council framework for developing and testing complex interventions. It combines classical effectiveness evaluation with a thorough process evaluation. The results from this study may inform the development of further trials aimed at promoting psychosocial well-being following stroke as well as inform the psychosocial follow up of stroke patients living at home

• Ommundsen, Nina; Wyller, Torgeir Bruun; Nesbakken, Arild; Bakka, Arne Olav; Jordhøy, Marit Slaaen & Skovlund, Eva [Show all 7 contributors for this article] (2018). Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer: a randomized controlled trial. Colorectal Disease. ISSN 1462-8910. 20(1), p. 16–25. doi: 10.1111/codi.13785.
• Hov, Karen Roksund; Bolstad, Nils; Idland, Ane-Victoria; Zetterberg, Henrik; Blennow, Kaj & Chaudhry, Farrukh Abbas [Show all 10 contributors for this article] (2017). Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 7(3), p. 374–385. doi: 10.1159/000481853. Full text in Research Archive
• Næss, Gro; Kirkevold, Marit; Hammer, Wenche; Straand, Jørund & Wyller, Torgeir Bruun (2017). Nursing care needs and services utilised by home-dwelling elderly with complex health problems: Observational study. BMC Health Services Research. ISSN 1472-6963. 17(1). doi: 10.1186/s12913-017-2600-x.
• Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Dahl, Gry Torsæter; Frihagen, Frede Jon & Brækhus, Anne [Show all 8 contributors for this article] (2017). Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 7(3), p. 309–317. doi: 10.1159/000478723. Full text in Research Archive
• Ernst, Gernot Walter; Watne, Leiv Otto; Frihagen, Frede Jon; Wyller, Torgeir Bruun; Dominik, Andreas & Rostrup, Morten (2017). Decreases in heart rate variability are associated with postoperative complications in hip fracture patients. PLOS ONE. ISSN 1932-6203. 12:e0180423(7), p. 1–14. doi: 10.1371/journal.pone.0180423. Full text in Research Archive
• Neerland, Bjørn Erik; Krogseth, Maria; Juliebø, Vibeke; Ranhoff, Anette Hylen; Engedal, Knut & Frihagen, Frede Jon [Show all 9 contributors for this article] (2017). Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study. PLOS ONE. ISSN 1932-6203. 12(7:e0180641), p. 1–18. doi: 10.1371/journal.pone.0180641. Full text in Research Archive
• Fjell, Anders Martin; Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv Otto; Borza, Tom & Brækhus, Anne [Show all 11 contributors for this article] (2017). Neuroinflammation and tau interact with amyloid in predicting sleep problems in aging independently of atrophy. Cerebral Cortex. ISSN 1047-3211. 28(8), p. 2775–2785. doi: 10.1093/cercor/bhx157.
• Kirkhus, Lene; Saltyte Benth, Jurate; Kristjansson, Siri Rostoft; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen & Selbæk, Geir [Show all 9 contributors for this article] (2017). Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty. British Journal of Cancer. ISSN 0007-0920. 117(4), p. 470–477. doi: 10.1038/bjc.2017.202. Full text in Research Archive Show summary

  Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ability to identify frailty is scarcely investigated. Methods: We compared oncologists’ classification of frailty (onc-frail) based on clinical judgement with a modified geriatric assessment (mGA), and investigated associations between frailty and overall survival. Patients X70 years referred for medical cancer treatment were eligible. mGA-frailty was defined as impairment in at least one of the following: daily activities, comorbidity, polypharmacy, physical function or at least one geriatric syndrome (cognitive impairment, depression, malnutrition, falls). Results: Three hundred and seven patients were enroled, 288 (94%) completed the mGA, 286 (93%) were rated by oncologists. Median age was 77 years, 56% had metastases, 85% performance status (PS) 0–1. Overall, 104/286 (36%) were onc-frail and 140/288 (49%) mGA-frail, the agreement was fair (kappa value 0.30 (95% CI 0.19; 0.41)), and 67 mGA-frail patients who frequently had localised disease, good PS and received curative treatment, were missed by the oncologists. Only mGA-frailty was independently prognostic for survival (HR 1.61, 95% CI 1.14; 2.27; P¼0.007). Conclusions: Systematic assessment of geriatric domains is needed to aid oncologists in identifying frail patients with poor survival.

• Sala Llonch, Roser; Idland, Ane-Victoria; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun & Brækhus, Anne [Show all 10 contributors for this article] (2017). Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition. Journal of Alzheimer's Disease. ISSN 1387-2877. 58(3), p. 829–840. doi: 10.3233/JAD-161146. Show summary

  Amyloid deposition occurs in aging, even in individuals free from cognitive symptoms, and is often interpreted as preclinical Alzheimer’s disease (AD) pathophysiology. YKL-40 is a marker of neuroinflammation, being increased in AD, and hypothesized to interact with amyloid-β (Aβ) in causing cognitive decline early in the cascade of AD pathophysiology. Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. We studied 89 participants (mean age: 73.1 years) with cerebrospinal fluid samples at baseline, and both MRI and cognitive assessments from two time-points separated by two years. We tested how baseline levels of Aβ42 and YKL-40 correlated with changes in cortical thickness and cognition. Thickness change correlated with Aβ42 only in Aβ42+ participants (<600 pg/mL, n = 27) in the left motor and premotor cortices. Aβ42 was unrelated to cognitive change. Increased YKL-40 was associated with less preservation of scores on the animal naming test in the total sample (r = –0.28, p = 0.012) and less preservation of a score reflecting global cognitive function for Aβ42+ participants (r = –0.58, p = 0.004). Our results suggest a role for inflammation in brain atrophy and cognitive changes in cognitively normal older adults, which partly depended on Aβ accumulation.

• Idland, Ane-Victoria; Roser, Sala-Llonch; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun & Brækhus, Anne [Show all 10 contributors for this article] (2017). CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of Aging. ISSN 0197-4580. 49, p. 138–144. doi: 10.1016/j.neurobiolaging.2016.09.012. Full text in Research Archive
• Millenaar, Joany; Hvidsten, Lara H. Thomasgaard; de Vugt, Marjolein; Engedal, Knut; Selbæk, Geir & Wyller, Torgeir Bruun [Show all 13 contributors for this article] (2017). Determinants of quality of life in young onset dementia - results from a European multicenter assessment. Aging & Mental Health. ISSN 1360-7863. 21(1), p. 24–30. doi: 10.1080/13607863.2016.1232369.
• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut & Bøhmer, Thomas [Show all 7 contributors for this article] (2017). Micronutrients and the risk of hip fracture: Case–control study. Clinical Nutrition. ISSN 0261-5614. 36(2), p. 438–443. doi: 10.1016/j.clnu.2015.12.014. Show summary

  Background: Vitamin D, and possibly vitamin K, has an established association to fracture risk. Other vitamins are, however, less studied. Aim: To determine whether specific micronutrients other than 25(OH)D and vitamin K play a role in risk of hip fracture and bone turnover. Methods: In this caseecontrol study, blood was drawn for measurements of vitamins A, B6, B12, C, E, and folic acid as well as the bone turnover markers osteocalcin and bone-specific alkaline phosphatase upon admission for hip fracture in 116 patients and in 73 home-dwelling non fractured controls. Results for vitamin K1 and 25(OH)D from the same populations have been reported previously. Results: Low vitamin A, C, and E concentrations were independently associated with a risk of hip fracture. The adjusted odds ratio (95% confidence interval) per 10 mmol/L increase in vitamin A concentration was 0.74 (0.65e0.84); for 1 mmol/L vitamin C and E: 0.94 (0.92e0.97) and 0.81 (0.74e0.89) respectively. The results were principally unchanged when 25(OH)D, vitamin K1, Body Mass Index, and other potential confounders were adjusted for. All vitamins except B12 and folic acid correlated positively with total osteocalcin and negatively with bone-specific alkaline phosphatase. Conclusions: Low vitamin A, C, and E concentrations are associated with an increased risk of hip fracture, possibly mediated through bone turnover mechanisms. This caseecontrol study is registered at: ClinicalTrials.gov. NCT01738776. The patient related outcome is also registered at: ClinicalTrials.gov. NCT01009268.

• Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Eri, Lars Magne; Frihagen, Frede Jon & Ræder, Johan [Show all 13 contributors for this article] (2016). Preclinical amyloid-β and axonal degeneration pathology in delirium. Journal of Alzheimer's Disease. ISSN 1387-2877. 55(1), p. 371–379. doi: 10.3233/JAD-160461.
• Hall, Roanna J.; Watne, Leiv Otto; Idland, Ane-Victoria; Ræder, Johan; Frihagen, Frede Jon & MacLullich, Alasdair M.J. [Show all 9 contributors for this article] (2016). Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture. Journal of Neuroinflammation. ISSN 1742-2094. 13:170. doi: 10.1186/s12974-016-0636-1.
• Neerland, Bjørn Erik; Hall, Roanna J.; Seljeflot, Ingebjørg; Frihagen, Frede Jon; MacLullich, Alasdair M.J. & Ræder, Johan [Show all 8 contributors for this article] (2016). Associations between delirium and preoperative cerebrospinal fluid C-reactive protein, interleukin-6, and interleukin-6 receptor in individuals with acute hip fracture. Journal of The American Geriatrics Society. ISSN 0002-8614. 64(7), p. 1456–1463. doi: 10.1111/jgs.14238.
• Watne, Leiv Otto; Idland, Ane-Victoria; Fekkes, Durk; Ræder, Johan; Frihagen, Frede Jon & Ranhoff, Anette Hylen [Show all 10 contributors for this article] (2016). Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity. BMC Geriatrics. ISSN 1471-2318. 16(149). doi: 10.1186/s12877-016-0324-0. Full text in Research Archive
• Hov, Karen Roksund; Berg, Jens Petter; Frihagen, Frede Jon; Ræder, Johan; Hall, Roanna J. & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2016). Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-Albumin. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. 41(3-4), p. 192–198. doi: 10.1159/000443789.
• Rønning, Benedicte; Wyller, Torgeir Bruun; Nesbakken, Arild; Skovlund, Eva; Jordhøy, Marit Slaaen & Bakka, Arne Olav [Show all 7 contributors for this article] (2016). Quality of life in older and frail patients after surgery for colorectal cancer-A follow-up study. Journal of Geriatric Oncology. ISSN 1879-4068. 7(3), p. 195–200. doi: 10.1016/j.jgo.2016.03.002. Show summary

  Objective The incidence of colorectal cancer is increasing, mainly due to the aging of the population. Frailty, describing a state of increased vulnerability, is common in older patients, but frailty and high age are not necessarily contraindications to surgical treatment. However, limited data describing long-term outcomes after surgery in this patient group exist. In this clinical follow-up study, we aimed to examine long-term health-related quality of life in older surgical patients with colorectal cancer. Materials and Methods Patients were recruited from a prospective multicenter study investigating frailty as a predictor of postoperative complications after surgery for colorectal cancer. A preoperative geriatric assessment was performed, and patients were classified as frail or non-frail. Patients responded to version 3.0 of The European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-C30 before surgery, 3 months postoperatively and at a long-term follow-up 16–28 months (median 22 months) after surgery. One-way repeated-measures analyses of variance were performed to examine changes in scores over time. Results 180 patients with a mean age of 80 years were included at baseline, 138 at 3 months postoperatively, and 84 patients (69% of survivors) at long-term follow-up. A significant improvement in quality of life-scores was present 3 months after surgery, also in the subgroup of frail patients. At long-term follow-up, scores decreased, but to values above baseline. Conclusion Health-related quality of life may be improved in older patients after surgery for colorectal cancer, even in patients who are classified as frail preoperatively.

• Krogseth, Maria; Watne, Leiv Otto; Juliebø, Vibeke; Skovlund, Eva; Engedal, Knut & Frihagen, Frede Jon [Show all 7 contributors for this article] (2016). Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. Archives of gerontology and geriatrics (Print). ISSN 0167-4943. 64, p. 38–44. doi: 10.1016/j.archger.2015.12.004.
• Hornslien, Astrid; Sandset, Else Charlotte; Wyller, Torgeir Bruun & Berge, Eivind (2015). Effects of candesartan in acute stroke on activities of daily livingand level of care at 6months. Journal of Hypertension. ISSN 0263-6352. 33(7), p. 1487–1491. doi: 10.1097/HJH.0000000000000581.

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• Wyller, Torgeir Bruun (2021). Foretaksmodellen innebærer at sykehusene driftes etter kvasikapitalistiske prinsipper. Det fører til at de prioriterer bedriftsøkonomisk «lønnsomhet» foran helsefaglig og samfunnsøkonomisk ansvarlighet. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(12), p. 1–3. doi: 10.4045/tidsskr.21.0573.
• Wyller, Torgeir Bruun; Gisvold, Sven Erik; Grøttumsbråten, Janne; Haug, Lene; Hove, Aud & Isumhaugen, Mariann [Show all 15 contributors for this article] (2021). Sykehusreformen har skapt byråkrati og svekket samarbeidet. Altaposten. p. 10–10.
• Wyller, Torgeir Bruun; Gisvold, Sven Erik; Grøttumsbråten, Janne; Haug, Lene; Hove, Aud & Isumhaugen, Mariann [Show all 15 contributors for this article] (2021). Sykehusreformen har skapt mer byråkrati og svekket samarbeidet. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. p. 22–22.
• Ranhoff, Anette Hylen; Myrstad, Marius; Kittang, Bård Reiakvam & Wyller, Torgeir Bruun (2021). Bør alle sykehjemsbeboere vaksineres? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(3), p. 210–210. doi: 10.4045/tidsskr.21.0072.
• Myrstad, Marius; Kittang, Bård Reiakvam; Ranhoff, Anette Hylen; Neerland, Bjørn Erik & Wyller, Torgeir Bruun (2020). Kortikosteroider til sykehjemspasienter med covid-19? . Tidsskrift for Den norske legeforening. ISSN 0029-2001.
• Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina & Wester, Per [Show all 12 contributors for this article] (2020). STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial. European Stroke Journal. ISSN 2396-9873. 5(4), p. 414–422. doi: 10.1177/2396987320954671. Full text in Research Archive
• Wyller, Torgeir Bruun (2020). Reell samhandling forebygger reinnleggelse. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(1), p. 1–3. doi: 10.4045/tidsskr.19.0724.
• Kirkhus, Lene; Saltyte-Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri & Harneshaug, Magnus [Show all 9 contributors for this article] (2020). Reply to the letter to the editor ‘Geriatric-oncology and palliative care: cautionary on using geriatric assessment as a sole basis to limit care’. Palliative Medicine. ISSN 0269-2163. 34(2), p. 255–256. doi: 10.1177/0269216319888987.
• Kirkhus, Lene; Benth, Jurate Saltyte; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri & Harneshaug, Magnus [Show all 9 contributors for this article] (2019). Reply to the letter to the editor 'Geriatric-oncology and palliative care: cautionary on using geriatric assessment as a sole basis to limit care'. Palliative Medicine. ISSN 0269-2163. doi: 10.1177/0269216319888987.
• Wyller, Torgeir Bruun & Gisvold, Sven Erik (2018). Kritisk sengemangel rammer de eldre. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(20), p. 1906–1906. doi: 10.4045/tidsskr.18.0855.
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Thingstad, Pernille; Askim, Torunn & Beyer, Mona K. [Show all 14 contributors for this article] (2018). The burden of post-stroke cognitive impairments in a Norwegian stroke population (Nor-COAST).
• Wyller, Torgeir Bruun (2018). Bør vi slutte å snakke om emosjonell inkontinens? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(8). doi: 10.4045/tidsskr.18.0048.
• Ommundsen, Nina; Wyller, Torgeir Bruun; Nesbakken, Arild; Bakka, Arne Olav; Jordhøy, Marit Slaaen & Skovlund, Eva [Show all 7 contributors for this article] (2018). Reply to Lawday et al. Colorectal Disease. ISSN 1462-8910. 20(4), p. 350–351. doi: 10.1111/codi.14059.
• Romskaug, Rita & Wyller, Torgeir Bruun (2018). Medikamentell behandling av eldre med fokus på kardiologiske legemidler. Hjerteforum. ISSN 0802-1465. 31, p. 42–48.
• Ihle-Hansen, Hege & Wyller, Torgeir Bruun (2017). Re: Akutte nevrologer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(4), p. 260–260. doi: 10.4045/tidsskr.17.0102.
• Wyller, Torgeir Bruun (2017). Fire saker valgkampen kunne handlet om. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(16), p. 1143–1143. doi: 10.4045/tidsskr.17.0610.
• Romskaug, Rita & Wyller, Torgeir Bruun (2017). Polyfarmasi hos eldre, Indremedisin I & II. Forlag Vett & Viten. ISSN 9788241207402. p. 465–472.
• SCHELLHORN, TILL; Thingstad, Pernille; Wyller, Torgeir Bruun; Saltvedt, Ingvild & Beyer, Mona K. (2017). Imaging in the NorCoast study: A multicentre, prospective cohort study on cognitive function following acute stroke.
• Wyller, Torgeir Bruun (2017). Presise epikriser. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(9), p. 641–642. doi: 10.4045/tidsskr.17.0105.
• Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva & Pitkala, Kaisu H [Show all 7 contributors for this article] (2017). Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial. Trials. ISSN 1745-6215. 18(1). doi: 10.1186/s13063-017-1900-0. Full text in Research Archive
• Wyller, Torgeir Bruun (2016). Re: Dagens studenter er fremtidens helseledere. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(22), p. 1875–1875. doi: 10.4045/tidsskr.16.0969.
• Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Re: En kvinne i 70-årene med rask forverring av kognitiv funksjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(16), p. 1325–1325. doi: 10.4045/tidsskr.16.0686.
• Kirkhus, Lene; Saltyte Benth, Jurate; Rostoft, Siri; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen & Selbæk, Geir [Show all 9 contributors for this article] (2016). P111 "Frailty and survival in old patients with cancer; clinical judgment and systematic geriatric assessments" JGO Volume 7/6 Supplement 1 Nov 16 S131-132.
• Saltvedt, Ingvild & Wyller, Torgeir Bruun (2016). Palliativ behandling av gamle. In Loge, Jon Håvard & Kaasa, Stein (Ed.), Palliasjon Nordisk lærebok. Gyldendal Akademisk. ISSN 9788205488403.
• Saltvedt, Ingvild; Askim, Torunn; Indredavik, Bent; Ihle-Hansen, Hege; Næss, Halvor & Thingstad, Pernille [Show all 9 contributors for this article] (2016). THE NORWEGIAN COGNITIVE IMPAIRMENT AFTER STROKE (Nor-COAST) STUDY .
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun & Kersten, Hege (2016). Cognitive characteristics in persons with young onset Alzheimer’s Disease and Frontotemporal Dementia in Nordic Memory Clinics.
• Romskaug, Rita; Wyller, Torgeir Bruun & Seljeseth, Yngve Müller (2015). Legemiddelgjennomgang - hvordan gå frem i praksis? Indremedisineren. ISSN 1891-1617.
• Bronken, Berit Arnesveen; Kirkevold, Marit; Martinsen, Randi; Wyller, Torgeir Bruun & Kvigne, Kari (2015). Aphasia following Stroke: Promoting psychosocial well-being: A feasibility study.
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun & Kersten, Hege (2015). Kognitive karakteristika hos yngre med demens i norske hukommelsesklinikker - Alzheimers demens og frontotemporallappsdemens.
• Wyller, Torgeir Bruun (2015). Re: Samhandlingsreformen - hva nå? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 135(21). doi: 10.4045/tidsskr.15.1125.
• Wyller, Torgeir Bruun (2015). Re: Hvordan sammenlikner vi kvalitet i helsetjenesten? :. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 135(16). doi: 10.4045/tidsskr.15.0824.
• Wyller, Torgeir Bruun (2015). Re: Legehelter – og antihelter :. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 135(20). doi: 10.4045/tidsskr.15.1072.

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