Torgeir Bruun Wyller

• Hagberg, Guri; Ihle-Hansen, Hege; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita; Beyer, Mona Kristiansen; Wyller, Torgeir Bruun; Müller, Ebba Gløersen; Pendlebury, Sarah T. & Selnes, Per (2020). No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - A seven-year follow-up study. BMC Neurology.  ISSN 1471-2377.  20, s 1- 11 . doi: 10.1186/s12883-020-01753-w Full text in Research Archive.
• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege; Vlachos, Georgios; Ursin, Marie Helene & Tangen, Gro Gujord (2020). Balance and Gait After First Minor Ischemic Stroke in People 70 Years of Age or Younger: A Prospective Observational Cohort Study. Physical Therapy.  ISSN 0031-9023.  100(5), s 798- 806 . doi: 10.1093/ptj/pzaa010 Full text in Research Archive. Show summary

  BACKGROUND: Two-thirds of patients with stroke experience only mild impairments in the acute phase, and the proportion of patients <70 years is increasing. Knowledge about balance and gait and predictive factors are scarce for this group. OBJECTIVE: The objective of this study was to explore balance and gait in the acute phase and after 3 and 12 months in patients <=70 years with minor ischemic stroke (National Institutes of Health Stroke Scale score <=3). This study also explored factors predicting impaired balance after 12 months. DESIGN: This study was designed as an explorative longitudinal cohort study. METHODS: Patients were recruited consecutively from 2 stroke units. Balance and gait were assessed with the Mini-Balance Evaluation Systems Test (Mini-BESTest), Timed Up and Go, and preferred gait speed. Predictors for impaired balance were explored using logistic regression. RESULTS: This study included 101 patients. Mean (SD) age was 55.5 (11.4) years, 20% were female, and mean (SD) National Institutes of Health Stroke Scale score was 0.6 (0.9) points. The Mini-BESTest, gait speed, and Timed Up and Go improved significantly from the acute phase to 3 months, and gait speed also improved from 3 to 12 months. At 12 months, 26% had balance impairments and 33% walked slower than 1.0 m/s. Poor balance in the acute phase (odds ratio = 0.92, 95% confidence interval = 0.85-0.95) was the only predictor of balance impairments (Mini-BESTest score <=22) at 12 months poststroke. LIMITATIONS: Limitations include lack of information about pre-stroke balance and gait impairment and poststroke exercise. Few women limited the generalizability. CONCLUSION: This study observed improvements in both balance and gait during the follow-up; still, about one-third had balance or gait impairments at 12 months poststroke. Balance in the acute phase predicted impaired balance at 12 months.

• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege; Vlachos, Georgios; Ursin, Marie Helene & Tangen, Gro Gujord (2020). Impairments in spatial navigation during walking in patients 70 years or younger with mild stroke. Topics in Stroke Rehabilitation.  ISSN 1074-9357.  27, s 601- 609 . doi: 10.1080/10749357.2020.1755814 Full text in Research Archive. Show summary

  Background: Spatial navigation, the ability to determine and maintain a route from one place to another, is needed for independence in everyday life. Knowledge about impairments in spatial navigation in people with mild stroke is scarce. Objectives: To explore impairments in spatial navigation in patients ≤70 years after first-ever mild ischemic stroke (NIHSS≤3) and to explore which variables are associated with these impairments 12 months later. Methods: Patients were examined in the acute phase, and after 3 and 12 months. To assess impairments in spatial navigation, we used the Floor Maze Test (FMT), with time and FMT-errors as outcomes. Patients’ perceived navigational skills were collected using self-report. Logistic regression was used to explore which variables (sociodemographic data, stroke characteristics, cognition, and mobility) were associated with impaired navigation ability. Results: Ninety-seven patients (20 females) were included. The mean (SD) age was 55.5 (11.4) years. Timed FMT improved significantly from the acute phase to 12 months (p = <.001). At 12 months, 24 (24.7%) of the participants walked through the maze with errors, and 22 (22.7%) reported spatial navigational problems. The Trail Making Test (TMT)-B was the only variable from the acute phase associated with FMT-errors at 12 months, and being female was the only variable associated with self-reported navigational problems at 12 months. Conclusion: Nearly one in four patients experienced spatial navigation problems 12 months after a mild stroke. Executive function (TMT-B), measured in the acute phase, was associated with navigational impairments (FMT-errors) at 12 months, and being female was associated with self-reported navigational problems

• Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv; Brækhus, Anne; Hansson, Oskar; Blennow, Kaj; Zetterberg, Henrik; Sørensen, Øystein; Walhovd, Kristine B; Wyller, Torgeir Bruun & Fjell, Anders Martin (2020). Biomarker Profiling Beyond Amyloid and Tau: Cerebrospinal Fluid Markers, Hippocampal Atrophy, and Memory Change in Cognitively Unimpaired Older Adults. Neurobiology of Aging.  ISSN 0197-4580.  93, s 1- 15 . doi: 10.1016/j.neurobiolaging.2020.04.002 Full text in Research Archive. Show summary

  Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1-42 (Aβ42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain β-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Aβ42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline

• Kjeldsen, Sverre; Halvorsen, Sigrun; Wyller, Torgeir Bruun; Bath, Philip M. & Sandercock, Peter (2020). Eivind Berge, MD, PhD, 1964-2020: Cardiologist Who Was Fighting Stroke. Stroke.  ISSN 0039-2499.  51(5), s 1353- 1355 . doi: 10.1161/STROKEAHA.120.029351
• Munthe-Kaas, Ragnhild; Aam, Stina; Ihle-Hansen, Hege; Lydersen, Stian; Knapskog, Anne Brita; Wyller, Torgeir Bruun; Fure, Brynjar; Thingstad, Pernille; Askim, Torunn; Beyer, Mona K.; Næss, Halvor; Seljeseth, Yngve Müller; Ellekjær, Hanne; Pendlebury, Sarah T. & Saltvedt, Ingvild (2020). Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study. Alzheimer's and Dementia: Translational Research and Clinical Interventions.  ISSN 2352-8737.  6:e12000(1), s 1- 9 . doi: 10.1002/trc2.12000 Full text in Research Archive.
• Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege & Molden, Espen (2020). Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging.  ISSN 1170-229X.  37(6), s 425- 433 . doi: 10.1007/s40266-020-00763-0 Full text in Research Archive. Show summary

  Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs in relation to pharmacogenetic variability in CYP2D6 metabolism among patients aged ≥ 70 years exposed to polypharmacy. Materials and methods: We included 173 patients with detailed information about drug use. The patients were retrospectively subjected to CYP2D6 genotyping, which comprised the most common variant alleles encoding reduced, absent, or increased CYP2D6 metabolism. In order to compare dosages across different CYP2D6-metabolized drugs, all prescribed daily doses were harmonized to the 'percent of a daily defined dose' (DDD). The mean harmonized DDD was compared between genotype-predicted normal metabolizers (NMs) and patients with reduced or absent CYP2D6 enzyme activity, defined as intermediate or poor metabolizers (IMs/PMs). Blood pressure, pulse, and patient proportions with orthostatism and bradycardia were also compared between genotype subgroups. Results: The genotype-predicted phenotype subgroups comprised 79 NMs (45.7%), 75 IMs (43.4%), and 16 PMs (9.2%). There were no differences in dosing of CYP2D6 substrates between NMs and IMs/PMs (p = 0.76). A higher proportion of CYP2D6 IMs/PMs experienced orthostatism (p = 0.03), while there were no significant subgroup differences for the other hemodynamic variables. Conclusion: In this real-life clinical setting of patients aged ≥ 70 years, dosing of CYP2D6 substrates were not adjusted according to genotype-predicted CYP2D6 metabolism. The increased occurrence of orthostatism in patients with reduced/absent CYP2D6 metabolism may indicate that individualized dosing based on genotype has the potential to prevent adverse effects in these vulnerable patients.

• Sajjad, Muhammad Umar; Blennow, Kaj; Knapskog, Anne Brita; Idland, Ane-Victoria; Chaudhry, Farrukh Abbas; Wyller, Torgeir Bruun; Zetterberg, Henrik & Watne, Leiv (2020). Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients. Journal of Alzheimer's Disease.  ISSN 1387-2877.  73(4), s 1363- 1372 . doi: 10.3233/JAD-190941
• Wyller, Torgeir Bruun (2020). «Hvileskjær» i pandemien må brukes til bedre planlegging for de eldste. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  140(8), s 1- 4 . doi: 10.4045/tidsskr.20.0325
• Wyller, Torgeir Bruun (2020). Reell samhandling forebygger reinnleggelse. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  140(1), s 1- 3 . doi: 10.4045/tidsskr.19.0724
• Evensen, Sigurd Storhaug; Bourke, Alan; Lydersen, Stian; Sletvold, Olav; Saltvedt, Ingvild; Wyller, Torgeir Bruun & Taraldsen, Kristin (2019). Motor activity across delirium motor subtypes in geriatric patients assessed using body-worn sensors: a Norwegian cross-sectional study. BMJ Open.  ISSN 2044-6055.  9:e026401(2), s 1- 7 . doi: 10.1136/bmjopen-2018-026401 Full text in Research Archive.
• Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin & Sletvold, Olav (2019). Delirium motor subtypes and prognosis in hospitalized geriatric patients ? A prospective observational study. Journal of Psychosomatic Research.  ISSN 0022-3999.  122, s 24- 28 . doi: 10.1016/j.jpsychores.2019.04.020 Full text in Research Archive.
• Hagberg, Guri; Fure, Brynjar; Sandset, Else Charlotte; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita; Nygård, Ståle; Wyller, Torgeir Bruun & Ihle-Hansen, Hege (2019). Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: Secondary analysis of a randomized controlled trial, a 7-year follow-up study. Vascular Health and Risk Management.  ISSN 1176-6344.  15, s 11- 18 . doi: 10.2147/VHRM.S191873 Full text in Research Archive.
• Hagberg, Guri; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita; Nygård, Ståle; Pendlebury, Sarah T.; Beyer, Mona K.; Wyller, Torgeir Bruun & Ihle-Hansen, Hege (2019). Predictors for Favorable Cognitive Outcome Post-Stroke: A-Seven-Year Follow-Up Study. Dementia and Geriatric Cognitive Disorders.  ISSN 1420-8008.  s 1- 11 . doi: 10.1159/000501850
• Halaas, Nathalie Bodd; Henjum, Kristi; Blennow, Kaj; Dakhil, Shams; Idland, Ane-Victoria; Nilsson, Lars; Sederevicius, Donatas; Vidal-Piñeiro, Didac; Walhovd, Kristine B; Wyller, Torgeir Bruun; Zetterberg, Henrik; Watne, Leiv & Fjell, Anders Martin (2019). CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral Cortex.  ISSN 1047-3211.  00, s 1- 12 . doi: 10.1093/cercor/bhz240 Full text in Research Archive.
• Hov, Karen Roksund; Neerland, Bjørn Erik; Undseth, Øystein; Wyller, Vegard Bruun Bratholm; MacLullich, Alasdair M.J.; Qvigstad, Eirik; Skovlund, Eva & Wyller, Torgeir Bruun (2019). The Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  34(7), s 974- 981 . doi: 10.1002/gps.5098 Full text in Research Archive.
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate; Bruvik, Frøydis Kristine & Kersten, Hege (2019). Quality of life of family carers of persons with young-onset compared to late-onset dementia. Aging & Mental Health.  ISSN 1360-7863.  24(9), s 1394- 1401 . doi: 10.1080/13607863.2019.1617245 Full text in Research Archive.
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate & Kersten, Hege (2019). Quality of Life in People with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter Study. Journal of Alzheimer's Disease.  ISSN 1387-2877.  67(1), s 197- 210 . doi: 10.3233/JAD-180479
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate & Kersten, Hege (2019). Quality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter. PLOS ONE.  ISSN 1932-6203.  14(7) . doi: 10.1371/journal.pone.0219859 Full text in Research Archive. Show summary

  Objectives To identify factors associated with QOL in carers of persons with young-onset Alzheimer’s (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period. Methods Eighty-eight family carers of community-dwelling people with young-onset AD (n = 50) and FTD (n = 38) recruited from Nordic memory clinics. Carer QOL was assessed using the Quality of Life–Alzheimer’s Disease questionnaire. Carer burden was assessed by the Relatives’ Stress scale and depressive symptoms by the Montgomery-Åsberg Depression Rating Scale. Factors associated with QOL in YOD and development in QOL over time were explored with growth mixture model trajectories and mixed model analyses. Results We identified two carer groups of persons with YOD following trajectories with better (n = 53) versus poorer (n = 30) QOL. Carers who reported more burden at baseline had greater odds of belonging to the poorer QOL group (OR 1.1 (1.0–1.2), p = 0.004). Analyses of the development in QOL showed a significant decline in QOL–AD scores among the AD-carers from baseline to two-year follow-up (p = 0.044), while the score remained stable among the FTD-carers. The FTD-carer group had significantly higher mean QOL–AD scores at one- and two-year follow-up (p = 0.022 and 0.045, respectively). However, the difference between the two groups regarding time trend was non-significant. Poorer QOL was associated with increased carer burden (p = 0.01), more depressive symptoms (p = 0.024), and being male carer (p = 0.038). Conclusion Higher care burden, more depressive symptoms, and being a male carer was associated with poorer QOL in family carers for persons with YOD. Carers of persons with AD may experience greater challenges in preserving QOL compared to carers of persons with FTD.

• Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Bergh, Sverre; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Kirkevold, Øyvind; Borza, Tom; Saltvedt, Ingvild & Jordhøy, Marit Slaaen (2019). Modifiable factors affecting older patients' quality of life and physical function during cancer treatment. Journal of Geriatric Oncology.  ISSN 1879-4068.  10(6), s 904- 912 . doi: 10.1016/j.jgo.2019.08.001 Full text in Research Archive. Show summary

  BACKGROUND: Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL during cancer treatment. METHODS: Prospective, multicenter study of 307 patients with cancer ≥70 years, referred for systemic treatment. Pre-treatment, a modified geriatric assessment (mGA) was performed, including registration of comorbidities, medications, nutritional status, cognitive function, depressive symptoms (Geriatric Depression Scale-15 [GDS]), and mobility (Timed Up and Go [TUG]). Patient-reported physical function (PF)-, global QoL-, and symptom scores were assessed at baseline, two, four, and six months by the EORTC Quality of Life Core Questionnaire-C30. The impact of mGA components and symptoms on patients' PF and global QoL scores during six months was investigated by linear mixed models. To identify groups following distinct PF trajectories, a growth mixture model was estimated. RESULTS: 288 patients were eligible, mean age was 76.9 years, 68% received palliative treatment. Higher GDS-scores and poorer TUG were independently associated with an overall level of poorer PF and global QoL throughout follow-up, as were more pain, dyspnea, and appetite loss, and sleep disturbance. Three groups with distinct PF trajectories were identified: a poor group exhibiting a non-linear statistically (p < .001) and clinically significant decline (≥10 points), an intermediate group with a statistically (p = .003), but not clinically significant linear decline, and a good group with a stable trajectory. Higher GDS-scores and poorer TUG, more pre-treatment pain and dyspnea were associated with higher odds of belonging to the poor compared to the good PF group. CONCLUSION: Depressive symptoms, reduced mobility, and more physical symptoms increased the risk of decrements in older patients' PF and global QoL scores during cancer treatment, and represent potential targets for interventions aiming at improving these outcomes.

• Kirkhus, Lene; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri; Harneshaug, Magnus; Selbæk, Geir; Wyller, Torgeir Bruun & Jordhøy, Marit Slaaen (2019). Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study. Palliative Medicine.  ISSN 0269-2163.  33(3), s 312- 322 . doi: 10.1177/0269216319825972 Full text in Research Archive.
• Mehlum, Maria Hollund; Liestøl, Knut; Wyller, Torgeir Bruun; Hua, Tsushung A.; Rostrup, Morten & Berge, Eivind (2019). Blood pressure variability in hypertensive patients with atrial fibrillation in the VALUE trial. Blood Pressure.  ISSN 0803-7051.  28(2), s 77- 83 . doi: 10.1080/08037051.2018.1524707
• Neerland, Bjørn Erik; Wyller, Torgeir Bruun & Wyller, Vegard Bruun Bratholm (2019). Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses. BMC Geriatrics.  ISSN 1471-2318.  19(23), s 1- 8 . doi: 10.1186/s12877-019-1035-0 Full text in Research Archive.
• Næss, Gro; Wyller, Torgeir Bruun & Kirkevold, Marit (2019). Structured follow-up of frail home-dwelling older people in primary health care: Is there a special need, and could a checklist be of any benefit? A qualitative study of experiences from registered nurses and their leaders. Journal of Multidisciplinary Healthcare.  ISSN 1178-2390.  12, s 675- 690 . doi: 10.2147/JMDH.S212283 Full text in Research Archive. Show summary

  Aim: To identify experiences and opinions about the need for a structured follow-up and to identify potential benefits and barriers to the use of a checklist (Sub Acute Functional decline in the Older people [SAFE]) when caring for frail home-dwelling older people. Background: The complexity of older peoples’ health situation requires more coordinated health care across health care levels and a better structured follow-up than is currently being offered, especially in the transitional phase between hospital discharge and primary care, but also in more stable phases at home. Design: This was a qualitative study using focus group interviews. Methods: Data were collected during six focus group interviews in three districts in a municipality. Nineteen registered nurses (RNs) and seventeen leaders responsible for the follow-up of frail home-dwelling older people participated. Participants were representatives of the RNs in homecare and their leaders. Results: Our results highlight that although most RNs and their leaders saw a number of significant benefits to conducting a structured assessment and follow-up of frail older people home care recipients, a number of barriers made this difficult to realize on a daily basis. Conclusion: There is no common perception that a structured follow-up of frail homedwelling older people in primary health care is an important and contributing factor to better quality of health care. Despite this, most RNs and leaders found that the use of a structured checklist such as SAFE was a benefit to achieving a structured follow-up of the frail older people. We identified several factors of importance to whether a structured follow-up with a checklist is conducted in home care.

• Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege; Pitkala, Kaisu H; Lundqvist, Christofer & Wyller, Torgeir Bruun (2019). Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial. JAMA Internal Medicine.  ISSN 2168-6106. . doi: 10.1001/jamainternmed.2019.5096 Full text in Research Archive.
• Wang-Hansen, Marte Sofie; Wyller, Torgeir Bruun; Hvidsten, Lara H. Thomasgaard & Kersten, Hege (2019). Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events?. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  75(5), s 627- 637 . doi: 10.1007/s00228-019-02624-1 Full text in Research Archive.
• Evensen, Sigurd; Saltvedt, Ingvild; Lydersen, Stian; Wyller, Torgeir Bruun; Taraldsen, Kristin & Sletvold, Olav (2018). Environmental factors and risk of delirium in geriatric patients: An observational study. BMC Geriatrics.  ISSN 1471-2318.  18(1) . doi: 10.1186/s12877-018-0977-y Full text in Research Archive.
• Halaas, Nathalie Bodd; Blennow, Kaj; Idland, Ane-Victoria; Wyller, Torgeir Bruun; Ræder, Johan; Frihagen, Frede Jon; Staff, Anne Cathrine; Zetterberg, Henrik & Watne, Leiv (2018). Neurofilament light in serum and cerebrospinal fluid of hip fracture patients with delirium. Dementia and Geriatric Cognitive Disorders.  ISSN 1420-8008.  46(5-6), s 346- 357 . doi: 10.1159/000494754 Full text in Research Archive.
• Hall, Roanna J.; Watne, Leiv; Cunningham, Emma; Zetterberg, Henrik; Shenkin, Susan D; Wyller, Torgeir Bruun & MacLullich, Alasdair M.J. (2018). CSF biomarkers in delirium: a systematic review. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  33(11), s 1479- 1500 . doi: 10.1002/gps.4720
• Hassel, Bjørnar; Mariussen, Espen; Idland, Ane-Victoria; Dahl, Gry Torsæter; Ræder, Johan; Frihagen, Frede Jon; Berg, Jens Petter; Chaudhry, Farrukh Abbas; Wyller, Torgeir Bruun & Watne, Leiv (2018). CSF sodium at toxic levels precedes delirium in hip fracture patients. Neurotoxicology.  ISSN 0161-813X.  69(December), s 11- 16 . doi: 10.1016/j.neuro.2018.08.010
• Hov, Karen Roksund; Neerland, Bjørn Erik; Andersen, Anders Mikal; Undseth, Øystein; Wyller, Vegard Bruun Bratholm; MacLullich, Alasdair M.J.; Skovlund, Eva; Qvigstad, Eirik & Wyller, Torgeir Bruun (2018). The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  19(29) . doi: 10.1186/s40360-018-0218-1 Full text in Research Archive.
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Bruvik, Frøydis Kristine & Kersten, Hege (2018). Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia. Dementia and Geriatric Cognitive Disorders.  ISSN 1420-8008.  45(1-2), s 91- 104 . doi: 10.1159/000487263
• Kirkevold, Marit; Bragstad, Line Kildal; Bronken, Berit Arnesveen; Kvigne, Kari Johanne; Martinsen, Randi; Hjelle, Ellen Gabrielsen; Kitzmüller, Gabriele; Mangset, Margrete; Angel, Sanne; Aadal, Lena; Eriksen, Siren; Wyller, Torgeir Bruun & Sveen, Unni (2018). Promoting psychosocial well-being following stroke: study protocol for a randomized, controlled trial. BMC Psychology.  ISSN 2050-7283.  6(12) . doi: 10.1186/s40359-018-0223-6 Full text in Research Archive. Show summary

  Background: Stroke is a major public health threat globally. Psychosocial well-being may be affected following stroke. Depressive symptoms, anxiety, general psychological distress and social isolation are prevalent. Approximately one third report depressive symptoms and 20% report anxiety during the first months or years after the stroke. Psychosocial difficulties may impact significantly on long-term functioning and quality of life, reduce the effects of rehabilitation services and lead to higher mortality rates. The aim of the study is to evaluate the effect of a previously developed and feasibility tested dialogue-based psychosocial intervention aimed at promoting psychosocial well-being and coping following stroke among stroke survivors with and without aphasia. Methods: The study will be conducted as a multicenter, randomized, single blind controlled trial with one intervention and one control arm. It will include a total of 330 stroke survivors randomly allocated into either an intervention group (dialogue-based intervention to promote psychosocial well-being) or a control group (usual care). Participants in the intervention group will receive eight individual sessions of supported dialogues in their homes during the first six months following an acute stroke. The primary outcome measure will be psychosocial well-being measured by the General Health Questionnaire (GHQ). Secondary outcome measures will be quality of life (SAQoL), sense of coherence (SOC), and depression (Yale). Process evaluation will be conducted in a longitudinal mixed methods study by individual qualitative interviews with 15–20 participants in the intervention and control groups, focus group interviews with the intervention personnel and data collectors, and a comprehensive analysis of implementation fidelity. Discussion: The intervention described in this study protocol is based on thorough development and feasibility work, guided by the UK medical research council framework for developing and testing complex interventions. It combines classical effectiveness evaluation with a thorough process evaluation. The results from this study may inform the development of further trials aimed at promoting psychosocial well-being following stroke as well as inform the psychosocial follow up of stroke patients living at home

• Ommundsen, Nina; Nesbakken, Arild; Wyller, Torgeir Bruun; Skovlund, Eva; Bakka, Arne Olav; Jordhøy, Marit Slaaen & Rostoft, Siri (2018). Post-discharge complications in frail older patients after surgery for colorectal cancer. European Journal of Surgical Oncology.  ISSN 0748-7983.  44(10), s 1542- 1547 . doi: 10.1016/j.ejso.2018.06.024 Full text in Research Archive.
• Ommundsen, Nina; Wyller, Torgeir Bruun; Nesbakken, Arild; Bakka, Arne Olav; Jordhøy, Marit Slaaen; Skovlund, Eva & Rostoft, Siri (2018). Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer: a randomized controlled trial. Colorectal Disease.  ISSN 1462-8910.  20(1), s 16- 25 . doi: 10.1111/codi.13785
• Torbergsen, Anne Cathrine; Watne, Leiv; Frihagen, Frede Jon; Wyller, Torgeir Bruun & Mowe, Morten (2018). Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial. Clinical Nutrition ESPEN.  ISSN 2405-4577. . doi: 10.1016/j.clnesp.2017.11.012
• Watne, Leiv Otto & Wyller, Torgeir Bruun (2018). Delirium - framleis underdiagnostisert. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(5) . doi: 10.4045/tidsskr.18.0118
• Ernst, Gernot Walter; Watne, Leiv Otto; Frihagen, Frede Jon; Wyller, Torgeir Bruun; Dominik, Andreas & Rostrup, Morten (2017). Decreases in heart rate variability are associated with postoperative complications in hip fracture patients. PLOS ONE.  ISSN 1932-6203.  12:e0180423(7), s 1- 14 . doi: 10.1371/journal.pone.0180423 Full text in Research Archive.
• Fjell, Anders Martin; Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv Otto; Borza, Tom; Brækhus, Anne; Lona, Tarjei; Zetterberg, Henrik; Blennow, Kaj; Wyller, Torgeir Bruun & Walhovd, Kristine B (2017). Neuroinflammation and tau interact with amyloid in predicting sleep problems in aging independently of atrophy. Cerebral Cortex.  ISSN 1047-3211.  28(8), s 2775- 2785 . doi: 10.1093/cercor/bhx157
• Hov, Karen Roksund; Bolstad, Nils; Idland, Ane-Victoria; Zetterberg, Henrik; Blennow, Kaj; Chaudhry, Farrukh Abbas; Frihagen, Frede Jon; Ræder, Johan; Wyller, Torgeir Bruun & Watne, Leiv Otto (2017). Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium. Dementia and geriatric cognitive disorders extra.  ISSN 1664-5464.  7(3), s 374- 385 . doi: 10.1159/000481853 Full text in Research Archive.
• Idland, Ane-Victoria; Roser, Sala-Llonch; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun; Brækhus, Anne; Zetterberg, Henrik; Blennow, Kaj; Walhovd, Kristine B & Fjell, Anders Martin (2017). CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of Aging.  ISSN 0197-4580.  49, s 138- 144 . doi: 10.1016/j.neurobiolaging.2016.09.012 Full text in Research Archive.
• Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Dahl, Gry Torsæter; Frihagen, Frede Jon; Brækhus, Anne; Hassel, Bjørnar & Watne, Leiv Otto (2017). Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture. Dementia and geriatric cognitive disorders extra.  ISSN 1664-5464.  7(3), s 309- 317 . doi: 10.1159/000478723 Full text in Research Archive.
• Kirkhus, Lene; Saltyte Benth, Jurate; Kristjansson, Siri Rostoft; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Harneshaug, Magnus & Jordhøy, Marit Slaaen (2017). Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty. British Journal of Cancer.  ISSN 0007-0920.  117(4), s 470- 477 . doi: 10.1038/bjc.2017.202 Full text in Research Archive. Show summary

  Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ability to identify frailty is scarcely investigated. Methods: We compared oncologists’ classification of frailty (onc-frail) based on clinical judgement with a modified geriatric assessment (mGA), and investigated associations between frailty and overall survival. Patients X70 years referred for medical cancer treatment were eligible. mGA-frailty was defined as impairment in at least one of the following: daily activities, comorbidity, polypharmacy, physical function or at least one geriatric syndrome (cognitive impairment, depression, malnutrition, falls). Results: Three hundred and seven patients were enroled, 288 (94%) completed the mGA, 286 (93%) were rated by oncologists. Median age was 77 years, 56% had metastases, 85% performance status (PS) 0–1. Overall, 104/286 (36%) were onc-frail and 140/288 (49%) mGA-frail, the agreement was fair (kappa value 0.30 (95% CI 0.19; 0.41)), and 67 mGA-frail patients who frequently had localised disease, good PS and received curative treatment, were missed by the oncologists. Only mGA-frailty was independently prognostic for survival (HR 1.61, 95% CI 1.14; 2.27; P¼0.007). Conclusions: Systematic assessment of geriatric domains is needed to aid oncologists in identifying frail patients with poor survival.

• Millenaar, Joany; Hvidsten, Lara H. Thomasgaard; de Vugt, Marjolein; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Johannessen, Aud; Haugen, Per Kristian; Bakker, Christian; van vliet, deliane; Koopmans, Raymond T. C. M.; Verhey, Frans R.J. & Kersten, Hege (2017). Determinants of quality of life in young onset dementia - results from a European multicenter assessment. Aging & Mental Health.  ISSN 1360-7863.  21(1), s 24- 30 . doi: 10.1080/13607863.2016.1232369
• Neerland, Bjørn Erik; Krogseth, Maria; Juliebø, Vibeke; Ranhoff, Anette Hylen; Engedal, Knut; Frihagen, Frede Jon; Ræder, Johan; Wyller, Torgeir Bruun & Watne, Leiv Otto (2017). Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study. PLOS ONE.  ISSN 1932-6203.  12(7:e0180641), s 1- 18 . doi: 10.1371/journal.pone.0180641 Full text in Research Archive.
• Næss, Gro; Kirkevold, Marit; Hammer, Wenche; Straand, Jørund & Wyller, Torgeir Bruun (2017). Nursing care needs and services utilised by home-dwelling elderly with complex health problems: Observational study. BMC Health Services Research.  ISSN 1472-6963.  17(1) . doi: 10.1186/s12913-017-2600-x
• Sala Llonch, Roser; Idland, Ane-Victoria; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun; Brækhus, Anne; Zetterberg, Henrik; Blennow, Kaj; Walhovd, Kristine B & Fjell, Anders Martin (2017). Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition. Journal of Alzheimer's Disease.  ISSN 1387-2877.  58(3), s 829- 840 . doi: 10.3233/JAD-161146 Show summary

  Amyloid deposition occurs in aging, even in individuals free from cognitive symptoms, and is often interpreted as preclinical Alzheimer’s disease (AD) pathophysiology. YKL-40 is a marker of neuroinflammation, being increased in AD, and hypothesized to interact with amyloid-β (Aβ) in causing cognitive decline early in the cascade of AD pathophysiology. Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. We studied 89 participants (mean age: 73.1 years) with cerebrospinal fluid samples at baseline, and both MRI and cognitive assessments from two time-points separated by two years. We tested how baseline levels of Aβ42 and YKL-40 correlated with changes in cortical thickness and cognition. Thickness change correlated with Aβ42 only in Aβ42+ participants (<600 pg/mL, n = 27) in the left motor and premotor cortices. Aβ42 was unrelated to cognitive change. Increased YKL-40 was associated with less preservation of scores on the animal naming test in the total sample (r = –0.28, p = 0.012) and less preservation of a score reflecting global cognitive function for Aβ42+ participants (r = –0.58, p = 0.004). Our results suggest a role for inflammation in brain atrophy and cognitive changes in cognitively normal older adults, which partly depended on Aβ accumulation.

• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut; Bøhmer, Thomas & Mowe, Morten (2017). Micronutrients and the risk of hip fracture: Case–control study. Clinical Nutrition.  ISSN 0261-5614.  36(2), s 438- 443 . doi: 10.1016/j.clnu.2015.12.014 Show summary

  Background: Vitamin D, and possibly vitamin K, has an established association to fracture risk. Other vitamins are, however, less studied. Aim: To determine whether specific micronutrients other than 25(OH)D and vitamin K play a role in risk of hip fracture and bone turnover. Methods: In this caseecontrol study, blood was drawn for measurements of vitamins A, B6, B12, C, E, and folic acid as well as the bone turnover markers osteocalcin and bone-specific alkaline phosphatase upon admission for hip fracture in 116 patients and in 73 home-dwelling non fractured controls. Results for vitamin K1 and 25(OH)D from the same populations have been reported previously. Results: Low vitamin A, C, and E concentrations were independently associated with a risk of hip fracture. The adjusted odds ratio (95% confidence interval) per 10 mmol/L increase in vitamin A concentration was 0.74 (0.65e0.84); for 1 mmol/L vitamin C and E: 0.94 (0.92e0.97) and 0.81 (0.74e0.89) respectively. The results were principally unchanged when 25(OH)D, vitamin K1, Body Mass Index, and other potential confounders were adjusted for. All vitamins except B12 and folic acid correlated positively with total osteocalcin and negatively with bone-specific alkaline phosphatase. Conclusions: Low vitamin A, C, and E concentrations are associated with an increased risk of hip fracture, possibly mediated through bone turnover mechanisms. This caseecontrol study is registered at: ClinicalTrials.gov. NCT01738776. The patient related outcome is also registered at: ClinicalTrials.gov. NCT01009268.

• Hall, Roanna J.; Watne, Leiv Otto; Idland, Ane-Victoria; Ræder, Johan; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Staff, Anne Cathrine; Wyller, Torgeir Bruun & Fekkes, Durk (2016). Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture. Journal of Neuroinflammation.  ISSN 1742-2094.  13:170 . doi: 10.1186/s12974-016-0636-1
• Hov, Karen Roksund; Berg, Jens Petter; Frihagen, Frede Jon; Ræder, Johan; Hall, Roanna J.; Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-Albumin. Dementia and Geriatric Cognitive Disorders.  ISSN 1420-8008.  41(3-4), s 192- 198 . doi: 10.1159/000443789
• Idland, Ane-Victoria; Wyller, Torgeir Bruun; Støen, Randi; Eri, Lars Magne; Frihagen, Frede Jon; Ræder, Johan; Chaudhry, Farrukh Abbas; Hansson, Oskar; Zetterberg, Henrik; Blennow, Kaj; Bogdanovic, Nenad; Brækhus, Anne & Watne, Leiv Otto (2016). Preclinical amyloid-β and axonal degeneration pathology in delirium. Journal of Alzheimer's Disease.  ISSN 1387-2877.  55(1), s 371- 379 . doi: 10.3233/JAD-160461
• Krogseth, Maria; Watne, Leiv Otto; Juliebø, Vibeke; Skovlund, Eva; Engedal, Knut; Frihagen, Frede Jon & Wyller, Torgeir Bruun (2016). Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. Archives of gerontology and geriatrics (Print).  ISSN 0167-4943.  64, s 38- 44 . doi: 10.1016/j.archger.2015.12.004
• Neerland, Bjørn Erik; Hall, Roanna J.; Seljeflot, Ingebjørg; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Ræder, Johan; Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Associations between delirium and preoperative cerebrospinal fluid C-reactive protein, interleukin-6, and interleukin-6 receptor in individuals with acute hip fracture. Journal of The American Geriatrics Society.  ISSN 0002-8614.  64(7), s 1456- 1463 . doi: 10.1111/jgs.14238
• Rønning, Benedicte; Wyller, Torgeir Bruun; Nesbakken, Arild; Skovlund, Eva; Jordhøy, Marit Slaaen; Bakka, Arne Olav & Kristjansson, Siri Rostoft (2016). Quality of life in older and frail patients after surgery for colorectal cancer-A follow-up study. Journal of Geriatric Oncology.  ISSN 1879-4068.  7(3), s 195- 200 . doi: 10.1016/j.jgo.2016.03.002 Show summary

  Objective The incidence of colorectal cancer is increasing, mainly due to the aging of the population. Frailty, describing a state of increased vulnerability, is common in older patients, but frailty and high age are not necessarily contraindications to surgical treatment. However, limited data describing long-term outcomes after surgery in this patient group exist. In this clinical follow-up study, we aimed to examine long-term health-related quality of life in older surgical patients with colorectal cancer. Materials and Methods Patients were recruited from a prospective multicenter study investigating frailty as a predictor of postoperative complications after surgery for colorectal cancer. A preoperative geriatric assessment was performed, and patients were classified as frail or non-frail. Patients responded to version 3.0 of The European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-C30 before surgery, 3 months postoperatively and at a long-term follow-up 16–28 months (median 22 months) after surgery. One-way repeated-measures analyses of variance were performed to examine changes in scores over time. Results 180 patients with a mean age of 80 years were included at baseline, 138 at 3 months postoperatively, and 84 patients (69% of survivors) at long-term follow-up. A significant improvement in quality of life-scores was present 3 months after surgery, also in the subgroup of frail patients. At long-term follow-up, scores decreased, but to values above baseline. Conclusion Health-related quality of life may be improved in older patients after surgery for colorectal cancer, even in patients who are classified as frail preoperatively.

• Watne, Leiv Otto; Idland, Ane-Victoria; Fekkes, Durk; Ræder, Johan; Frihagen, Frede Jon; Ranhoff, Anette Hylen; Chaudhry, Farrukh Abbas; Engedal, Knut; Wyller, Torgeir Bruun & Hassel, Bjørnar (2016). Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity. BMC Geriatrics.  ISSN 1471-2318.  16(149) . doi: 10.1186/s12877-016-0324-0 Full text in Research Archive.
• Hornslien, Astrid; Sandset, Else Charlotte; Wyller, Torgeir Bruun & Berge, Eivind (2015). Effects of candesartan in acute stroke on activities of daily livingand level of care at 6months. Journal of Hypertension.  ISSN 0263-6352.  33(7), s 1487- 1491 . doi: 10.1097/HJH.0000000000000581
• Ihle-Hansen, Hege; Thommessen, Bente; Fagerland, Morten; Øksengård, Anne Rita; Wyller, Torgeir Bruun; Engedal, Knut & Fure, Brynjar (2015). Blood pressure control to prevent decline in cognition after stroke. Vascular Health and Risk Management.  ISSN 1176-6344.  11, s 311- 316 . doi: 10.2147/VHRM.S82839
• Kersten, Hege; Hvidsten, Lara H. Thomasgaard; Gløersen, Gløer; Wyller, Torgeir Bruun & Wang-Hansen, Marte Sofie (2015). Clinical impact of potentially inappropriate medications during hospitalization of acutely ill older patients with multimorbidity. Scandinavian Journal of Primary Health Care.  ISSN 0281-3432.  33(4), s 243- 251 . doi: 10.3109/02813432.2015.1084766
• Lund, Anne; Mangset, Margrete; Wyller, Torgeir Bruun & Sveen, Unni (2015). Occupational transaction after stroke constructed as threat and balance. Journal of Occupational Science (JOS).  ISSN 1442-7591.  22(2), s 146- 159 . doi: 10.1080/14427591.2013.770363 Show summary

  Older adults who have had a stroke may experience anxiety, depression and difficulties participating in meaningful occupations while also experiencing excitement, discovery and satisfaction in creating a new occupational balance. The aim of this qualitative study was to explore how older adults experienced the changes in their everyday occupations after a stroke. Five women and three men who had experienced a mild to moderate stroke participated in focus group discussions. Systematic text condensation was applied. The participants’ experiences revealed how the stroke was perceived as an ‘occupational threat’ that produced feelings of social exclusion which were experienced as occupational exclusion, deprivation, marginalisation and imbalance. However, at the same time, the participants reconstructed occupational balance by performing occupations in new ways. The participants’ experiences provided insight into how they perceived their occupations as threatened after their stroke, while at the same time endeavoring to reconstruct occupational balance. These findings indicate that everyday life after stroke is a time of transaction where people are actively involved in creating control, occupational balance and being socially included. Keywords: Older adults, Occupational threat, Occupational balance, Stroke, Participation, Focus groups

• Mellingsæter, Marte; Wyller, Torgeir Bruun; Ranhoff, Anette Hylen; Bogdanovic, Nenad & Wyller, Vegard Bruun (2015). Reduced sympathetic response to head-up tilt in subjects with mild cognitive impairment or mild Alzheimer's dementia. Dementia and geriatric cognitive disorders extra.  ISSN 1664-5464.  5(1), s 107- 115 . doi: 10.1159/000375297 Full text in Research Archive.
• Mellingsæter, Marte; Wyller, Torgeir Bruun; Ranhoff, Anette Hylen & Wyller, Vegard Bruun (2015). Fit elderly men can also stand: orthostatic tolerance and autonomic cardiovascular control in elderly endurance athletes. Aging Clinical and Experimental Research.  ISSN 1594-0667.  27(4), s 499- 505 . doi: 10.1007/s40520-014-0303-2
• Neerland, Bjørn Erik; Hov, Karen Roksund; Wyller, Vegard Bruun; Qvigstad, Eirik; Skovlund, Eva; MacLullich, AM & Wyller, Torgeir Bruun (2015). The protocol of the oslo study of clonidine in elderly patients with delirium; LUCID: A randomised placebo-controlled trial. BMC Geriatrics.  ISSN 1471-2318.  15:7, s 1- 14 . doi: 10.1186/s12877-015-0006-3
• Skrede, Kjersti; Wyller, Torgeir Bruun; Watne, Leiv Otto; Seljeflot, Ingebjørg & Juliebø, Vibeke (2015). Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients. BMC Research Notes.  ISSN 1756-0500.  8(1) . doi: 10.1186/s13104-015-1129-5
• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Frihagen, Frede Jon; Wyller, Torgeir Bruun; Brugård, Anniken & Mowe, Morten (2015). Vitamin deficiency as a risk factor for delirium. European Geriatric Medicine.  ISSN 1878-7649.  6(4), s 314- 318 . doi: 10.1016/j.eurger.2014.09.002
• Torbergsen, Anne Cathrine; Watne, Leiv Otto; Wyller, Torgeir Bruun; Frihagen, Frede Jon; Strømsøe, Knut; Bøhmer, Thomas & Mowe, Morten (2015). Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clinical Nutrition.  ISSN 0261-5614.  34(1), s 101- 106 . doi: 10.1016/j.clnu.2014.01.016
• Ihle-Hansen, Hege Beate; Thommessen, Bente; Fagerland, Morten; Øksengård, Anne Rita; Wyller, Torgeir Bruun; Engedal, Knut Arne & Fure, Brynjar (2014). Effect on anxiety and depression of a multifactorial risk factor intervention program after stroke and TIA: a randomized controlled trial. Aging & Mental Health.  ISSN 1360-7863.  18(5), s 540- 546 . doi: 10.1080/13607863.2013.824406
• Ihle-Hansen, Hege Beate; Thommessen, Bente; Fagerland, Morten; Øksengård, Anne Rita; Wyller, Torgeir Bruun; Engedal, Knut & Fure, Brynjar (2014). Multifactorial vascular risk factor intervention to prevent cognitive impairment after stroke and TIA: a 12-month randomized controlled trial. International Journal of Stroke.  ISSN 1747-4930.  9(7), s 932- 938 . doi: 10.1111/j.1747-4949.2012.00928.x
• Kersten, Hege & Wyller, Torgeir Bruun (2014). Anticholinergic Drug Burden in Older People's Brain - How well is it Measured?. Basic & Clinical Pharmacology & Toxicology.  ISSN 1742-7835.  114(2), s 151- 159 . doi: 10.1111/bcpt.12140
• Kersten, Hege; Wyller, Torgeir Bruun & Molden, Espen (2014). Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs. Therapeutic Drug Monitoring.  ISSN 0163-4356.  36(1), s 125- 130 . doi: 10.1097/FTD.0b013e31829da990
• Krogseth, Maria; Wyller, Torgeir Bruun; Engedal, Knut Arne & Juliebø, Vibeke (2014). Delirium is a risk factor for institutionalization and functional decline in older hip fracture patients. Journal of Psychosomatic Research.  ISSN 0022-3999.  76(1), s 68- 74 . doi: 10.1016/j.jpsychores.2013.10.006

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• Kirkhus, Lene; Saltyte-Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri; Harneshaug, Magnus; Selbæk, Geir; Wyller, Torgeir Bruun & Slaaen, Marit (2020). Reply to the letter to the editor ‘Geriatric-oncology and palliative care: cautionary on using geriatric assessment as a sole basis to limit care’. Palliative Medicine.  ISSN 0269-2163.  34(2), s 255- 256 . doi: 10.1177/0269216319888987
• Kirkhus, Lene; Benth, Jurate Saltyte; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri; Harneshaug, Magnus; Selbæk, Geir; Wyller, Torgeir Bruun & Jordhøy, Marit Slaaen (2019). Reply to the letter to the editor 'Geriatric-oncology and palliative care: cautionary on using geriatric assessment as a sole basis to limit care'. Palliative Medicine.  ISSN 0269-2163. . doi: https://dx.doi.org/10.1177/0269216319888987
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Thingstad, Pernille; Askim, Torunn; Beyer, Mona K.; Knapskog, Anne-Brita; Næss, Halvor; Seljeseth, Yngve Müller; Ellekjær, Hanne; Wyller, Torgeir Bruun; Fure, Brynjar; Pendlebury, Sarah & Ihle-Hansen, Hege (2018). The burden of post-stroke cognitive impairments in a Norwegian stroke population (Nor-COAST).
• Ommundsen, Nina; Wyller, Torgeir Bruun; Nesbakken, Arild; Bakka, Arne Olav; Jordhøy, Marit Slaaen; Skovlund, Eva & Rostoft, Siri (2018). Reply to Lawday et al.. Colorectal Disease.  ISSN 1462-8910.  20(4), s 350- 351 . doi: 10.1111/codi.14059
• Romskaug, Rita & Wyller, Torgeir Bruun (2018). Medikamentell behandling av eldre med fokus på kardiologiske legemidler. Hjerteforum.  ISSN 0802-1465.  31, s 42- 48
• Wyller, Torgeir Bruun (2018). Bør vi slutte å snakke om emosjonell inkontinens?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(8) . doi: 10.4045/tidsskr.18.0048
• Wyller, Torgeir Bruun & Gisvold, Sven Erik (2018). Kritisk sengemangel rammer de eldre. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(20), s 1906- 1906 . doi: 10.4045/tidsskr.18.0855
• Ihle-Hansen, Hege & Wyller, Torgeir Bruun (2017). Re: Akutte nevrologer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(4), s 260- 260 . doi: 10.4045/tidsskr.17.0102
• Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva; Pitkala, Kaisu H & Wyller, Torgeir Bruun (2017). Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial. Trials.  ISSN 1745-6215.  18(1) . doi: 10.1186/s13063-017-1900-0 Full text in Research Archive.
• Romskaug, Rita & Wyller, Torgeir Bruun (2017). Polyfarmasi hos eldre, I:  Indremedisin I & II.  Forlag Vett & Viten.  ISBN 9788241207402.  Kapittel 83.  s 465 - 472
• SCHELLHORN, TILL; Thingstad, Pernille; Wyller, Torgeir Bruun; Saltvedt, Ingvild & Beyer, Mona K. (2017). Imaging in the NorCoast study: A multicentre, prospective cohort study on cognitive function following acute stroke.
• Wyller, Torgeir Bruun (2017). Fire saker valgkampen kunne handlet om. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(16), s 1143- 1143 . doi: 10.4045/tidsskr.17.0610
• Wyller, Torgeir Bruun (2017). Presise epikriser. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(9), s 641- 642 . doi: 10.4045/tidsskr.17.0105
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun & Kersten, Hege (2016). Cognitive characteristics in persons with young onset Alzheimer’s Disease and Frontotemporal Dementia in Nordic Memory Clinics.
• Kirkhus, Lene; Saltyte Benth, Jurate; Rostoft, Siri; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Harneshaug, Magnus & Jordhøy, Marit Slaaen (2016). P111 "Frailty and survival in old patients with cancer; clinical judgment and systematic geriatric assessments" JGO Volume 7/6 Supplement 1 Nov 16 S131-132.
• Saltvedt, Ingvild; Askim, Torunn; Indredavik, Bent; Ihle-Hansen, Hege; Næss, Halvor; Thingstad, Pernille; Wyller, Torgeir Bruun; Seljeseth, Yngve Müller & Beyer, Mona K. (2016). THE NORWEGIAN COGNITIVE IMPAIRMENT AFTER STROKE (Nor-COAST) STUDY.
• Saltvedt, Ingvild & Wyller, Torgeir Bruun (2016). Palliativ behandling av gamle, I: Jon Håvard Loge & Stein Kaasa (red.),  Palliasjon Nordisk lærebok.  Gyldendal Akademisk.  ISBN 9788205488403.  Kap 19.
• Wyller, Torgeir Bruun (2016). Re: Dagens studenter er fremtidens helseledere. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(22), s 1875- 1875 . doi: 10.4045/tidsskr.16.0969
• Wyller, Torgeir Bruun & Watne, Leiv Otto (2016). Re: En kvinne i 70-årene med rask forverring av kognitiv funksjon. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(16), s 1325- 1325 . doi: 10.4045/tidsskr.16.0686
• Bronken, Berit Arnesveen; Kirkevold, Marit; Martinsen, Randi; Wyller, Torgeir Bruun & Kvigne, Kari (2015). Aphasia following Stroke: Promoting psychosocial well-being: A feasibility study.
• Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun & Kersten, Hege (2015). Kognitive karakteristika hos yngre med demens i norske hukommelsesklinikker - Alzheimers demens og frontotemporallappsdemens..
• Hvidsten, Lara Hisami Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Høgh, Peter; Snaedal, Jon; Johannessen, Aud; Haugen, Per Kristian & Kersten, Hege (2015). Young Onset Dementia study - A Prospective Cohort Study of Quality of Life and Specific Needs in Persons with Young Onset Dementia and their Families. Journal of Clinical Trials.  ISSN 2167-0870.  5(1) . doi: 10.4172/2167-0870.1000204 Show summary

  Background: Young-Onset Dementia (YOD) causes challenges and concerns that are likely to affect quality of life and generate specific needs for health care, which may be different from what is observed in late onset dementia. The knowledge about the impact of YOD, in particular Fronto Temporal Dementia (FTD), on the affected families is scarce, and previous studies have underscored the importance of differentiating between diagnostic subgroups of YOD in future research. Accordingly, the aims of this study are to identify and compare factors influencing quality of life between persons with young onset FTD and Alzheimer’s Dementia (AD) and their families as the condition progresses. An additional aim is to compare the use of health care services among younger and older persons with dementia, and to investigate the life-stage specific needs for health care services in persons with YOD. Methods/Design: This is a two-year observational Nordic multicentre cohort study of community-dwelling persons with YOD and their families. Two diagnostic subgroups, each consisting of 75 dyads with AD and 75 dyads with FTD with symptom debut <65 years, will be included, and compared with a control group consisting of 100 older persons with dementia and onset >70 years. Participants are recruited from nine Nordic memory clinics. Comprehensive assessments are made at baseline, 12 and 24 months, supplemented with telephone follow-ups at 6 and 18 months. Primary outcome measure is Quality of life measured by Quality of Life in Alzheimer’s Disease (QoL-AD) and EuroQol-5D (EQ-5D). Secondary outcome measures are needs for health care services measured by Camberwell Assessment of Needs in the Elderly (CANE) and Resource Utilization in Dementia Lite (RUD Lite). The inclusion period is from February 2014 to February 2015, with follow-up data collection until February 2017. Conclusion: The sample size, the outcome measures, and the explanatory factors chosen in this study will provide new knowledge of quality of life in families with young onset FTD and AD, and contribute to tailoring the health care services to the life stage-specific needs of families with YOD. ClinicalTrials.gov identifier: NCT02055092

• Johnsen, Lars Gunnar; Watne, Leiv Otto; Frihagen, Frede Jon; Helbostad, Jorunn L.; Prestmo, Anders; Saltvedt, Ingvild; Sletvold, Olav & Wyller, Torgeir Bruun (2015). Hvorfor ortogeriatri?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(6), s 523- 524 . doi: 10.4045/tidsskr.15.0188
• Romskaug, Rita; Wyller, Torgeir Bruun & Seljeseth, Yngve Müller (2015). Legemiddelgjennomgang - hvordan gå frem i praksis?. Indremedisineren.  ISSN 1891-1617.  (4)
• Røe, Oluf Dimitri & Wyller, Torgeir Bruun (2015). Hva står på spill med lokalsykehusene? :. Bioingeniøren.  ISSN 0801-6828.  50(6), s 36- 37
• Wyller, Torgeir Bruun (2015). Re: Hvordan sammenlikner vi kvalitet i helsetjenesten? :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(16), s 1427 . doi: 10.4045/tidsskr.15.0824
• Wyller, Torgeir Bruun (2015). Re: Legehelter – og antihelter :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(20), s 1813 . doi: 10.4045/tidsskr.15.1072
• Wyller, Torgeir Bruun (2015). Re: Samhandlingsreformen - hva nå?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(21), s 1920 . doi: 10.4045/tidsskr.15.1125
• Mellingsæter, Marte; Wyller, Torgeir Bruun & Steen, Torkel (2014). Eldre kvinne med uforklarte fall og ilinger gjennom hodet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(07), s 717- 720 . doi: 10.4045/tidsskr.13.1288
• Neerland, Bjørn Erik; Ahmed, Marc; Watne, Leiv Otto; Roksund Hov, Karen & Wyller, Torgeir Bruun (2014). Ny bevissthetsskala ved delirium. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(2), s 150- 150 . doi: 10.4045/tidsskr.13.1603

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