Trine Ranheim

• Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R; Kvitting, John Peder Escobar; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom Eirik; Nilsson, Per; Louwe, Maria Cornelia & Ranheim, Trine (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects. Open heart.  ISSN 2053-3624.  6.e001098(2), s 1- 8 . doi: 10.1136/openhrt-2019-001098 Full text in Research Archive.
• Sokolova, Marina; Ranheim, Trine; Louwe, Maria Cornelia; Halvorsen, Bente; Yndestad, Arne & Aukrust, Pål (2019). NLRP3 inflammasome: A novel player in metabolically induced inflammation-potential influence on the myocardium. Journal of Cardiovascular Pharmacology.  ISSN 0160-2446.  74(4), s 276- 284 . doi: 10.1097/FJC.0000000000000704 Full text in Research Archive.
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2019). NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology.  ISSN 1664-3224.  10:1621(JULY), s 1- 13 . doi: 10.3389/fimmu.2019.01621 Full text in Research Archive.
• Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine; Vinge, Leif Erik; Aukrust, Pål; Stensløkken, Kåre-Olav; Yndestad, Arne & Sandanger, Øystein (2019). Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts. Frontiers in Immunology.  ISSN 1664-3224.  10 . doi: 10.3389/fimmu.2019.01285 Full text in Research Archive.
• Yang, Kuan; Lauritzen, Knut Husø; Olsen, Maria Belland; Dahl, Tuva Børresdatter; Ranheim, Trine; Ahmed, Muhammad Shakil; Attramadal, Håvard; Aukrust, Pål; Halvorsen, Bente; Nyman, Tuula Anneli; Sandanger, Øystein & Yndestad, Arne (2019). Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes. Journal of Immunology.  ISSN 0022-1767.  203(6), s 1598- 1608 . doi: 10.4049/jimmunol.1801382
• Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine; Sagen, Ellen Lund; Halvorsen, Bente; Saugstad, Ola Didrik & Yndestad, Arne (2019). Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy. Neonatology.  ISSN 1661-7800.  115(4), s 355- 362 . doi: 10.1159/000497200 Full text in Research Archive. Show summary

  Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate release of IL-1β and IL-18. NLRP3 has previously been shown to be upregulated following neonatal hypoxic-ischemic (HI) brain injury in mice, but with no early effect on brain injury. Objective: We aimed to evaluate if deficiency of NLRP3 or ASC protects against neonatal HI brain damage 7 days after hypoxia-ischemia. Methods: C57BL/6J, NLRP3–/–, and ASC–/– mice were subjected to unilateral common carotid artery ligation followed by hypoxia at P9. Brain infarction, apoptosis, and microglial response were evaluated, as well as total RNA sequencing and examination of plasma levels of systemic proinflammatory cytokines. Results: NLRP3–/– mice showed significantly increased brain infarction volumes compared to wild-type (Wt) mice, while ASC–/– mice showed reduced brain infarction volumes after neonatal hypoxia-ischemia. The amount of activated microglia was increased in NLRP3–/– mice, while decreased in ASC–/– mice compared to Wt mice. Total RNA sequencing showed an impaired inflammatory transcriptional response in the hippocampus of NLRP3–/– mice. Plasma levels of IL-1β and IL-18 were not affected, but TNF was lower in NLRP3–/– and ASC–/– mice compared to Wt mice. Conclusion: ASC deficiency is neuroprotective in neonatal HI brain damage in mice, while NLRP3 deficiency increases brain damage.

• Sokolova, Marina; Sahraoui, Afaf; Høyem, Merete; Øgaard, Jonas; Lien, Egil; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine & Scholz, Hanne (2018). NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  315(5), s E912- E923 . doi: 10.1152/ajpendo.00461.2017
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika; Ranheim, Trine; Alfsnes, Katrine; Fiane, Arnt E; Aakhus, Svend; Lunde, Ida Gjervold; Dahl, Christen Peder; Aukrust, Pål; Christensen, Geir Arve; Gullestad, Lars; Yndestad, Arne & Ueland, Thor (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine.  ISSN 0946-2716.  95(7), s 767- 777 . doi: 10.1007/s00109-017-1529-1
• Bermudez, Beatriz; Dahl, Tuva Børresdatter; Medina, Indira; Groeneweg, Mathijs; Holm, Sverre; Montserrat-De La Paz, Sergio; Rousch, Mat; Otten, Jeroen; Hérias, Veronica; Varela, Lourdes M.; Ranheim, Trine; Yndestad, Arne; Ortega-Gomez, Almudena; Abia, Rocio; Nagy, Laszlo; Aukrust, Pål; Muriana, Francisco J.G.; Halvorsen, Bente & Biessen, Erik Anna Leonardus (2017). Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPARγ-dependent monocyte differentiation and function. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  37(6), s 1157- 1167 . doi: 10.1161/ATVBAHA.116.308187
• Dhondup, Yangchen; Sjaastad, Ivar; Sandanger, Øystein; Aronsen, Jan Magnus; Ahmed, Muhammad Shakil; Attramadal, Håvard; Finsen, Alexandra; Zhang, Lili; Ranheim, Trine; Alfsnes, Katrine; Aukrust, Pål; Christensen, Geir Arve; Yndestad, Arne & Vinge, Leif Erik (2017). Toll-like receptor 9 promotes survival in SERCA2a KO heart failure mice. Mediators of Inflammation.  ISSN 0962-9351.  2017:9450439, s 1- 11 . doi: 10.1155/2017/9450439 Full text in Research Archive.
• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen; Attramadal, Håvard; Torp, May-Kristin; Fosshaug, Linn Elisabeth Lillerud; Rashidi, Azita; Lien, Egil; Finsen, Alexandra; Sandanger, Øystein; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2017). Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(2), s 234- 245 . doi: 10.1016/j.bbalip.2016.11.003
• Sandanger, Øystein; Gao, E; Ranheim, Trine; Bliksøen, Marte; Kaasbøll, Ole Jørgen; Alfsnes, Katrine; Nymo, Ståle Haugset; Rashidi, Azita; Ohm, Ingrid Kristine; Attramadal, Håvard; Aukrust, Pål; Vinge, Leif Erik & Yndestad, Arne (2016). NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  469(4), s 1012- 1020 . doi: 10.1016/j.bbrc.2015.12.051
• Varghese, Paramel G; Folkersen, Lasse; Strawbridge, Rona J.; Halvorsen, Bente; Yndestad, Arne; Ranheim, Trine; Krogh-Sørensen, Kristin; Skjelland, Mona; Espevik, Terje; Aukrust, Pål; Lengquist, Mariette; Hedin, Ulf; Jansson, Jan-Håkan; Fransen, Karin; Hansson, Göran K.; Eriksson, Per & Sirsjø, Allan (2016). NLRP3 inflammasome expression and activation in human atherosclerosis. Journal of the American Heart Association.  ISSN 2047-9980.  5:e003031(5), s 1- 14 . doi: 10.1161/JAHA.115.003031 Full text in Research Archive.
• Dhondup, Yangchen; Sjaastad, Ivar; Scott, Helge; Sandanger, Øystein; Zhang, Lili; Haugstad, Solveig Bjærum; Aronsen, Jan Magnus; Ranheim, Trine; Holmen, Sigve; Alfsnes, Katrine; Ahmed, Muhammad Shakil; Attramadal, Håvard; Gullestad, Lars; Aukrust, Pål; Christensen, Geir Arve; Yndestad, Arne & Vinge, Leif Erik (2015). Sustained toll-like receptor 9 activation promotes systemic and cardiac inflammation, and aggravates diastolic heart failure in SERCA2a KO Mice. PLOS ONE.  ISSN 1932-6203.  10:e0139715(10) . doi: 10.1371/journal.pone.0139715 Full text in Research Archive.
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2015). Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  309(4), s L378- L387 . doi: 10.1152/ajplung.00342.2014
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2015). Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  309, s L378- L387 . doi: 10.1152/ajplung.00342.2014
• Astrup, Elisabeth; Ranheim, Trine; Damås, Jan Kristian; Davi, Giovanni; Santilli, Francesca; Jensenius, Mogens; Vitale, Giustina; Aukrust, Pål; Olano, Juan P & Otterdal, Kari (2014). Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection. BMC Infectious Diseases.  ISSN 1471-2334.  14(1) . doi: 10.1186/1471-2334-14-70 Full text in Research Archive.
• Finsen, Alexandra; Ueland, Thor; Sjaastad, Ivar; Ranheim, Trine; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Askevold, Erik Tandberg; Aakhus, Svend; Husberg, Cathrine; Fiane, Arnt E; Lipp, Martin; Gullestad, Lars; Christensen, Geir Arve; Aukrust, Pål & Yndestad, Arne (2014). The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling. PLOS ONE.  ISSN 1932-6203.  9, s e112172 . doi: 10.1371/journal.pone.0112172
• Ohm, Ingrid Kristine; Alfsnes, Katrine; Olsen, Maria Belland; Ranheim, Trine; Sandanger, Øystein; Dahl, Tuva Børresdatter; Aukrust, Pål; Finsen, Alexandra; Yndestad, Arne & Vinge, Leif Erik (2014). Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLOS ONE.  ISSN 1932-6203.  9:e0104398(8) . doi: 10.1371/journal.pone.0104398
• Ohm, Ingrid Kristine; Gao, Erhe; Olsen, Maria Belland; Alfsnes, Katrine; Bliksøen, Marte; Øgaard, Jonas; Ranheim, Trine; Nymo, Ståle Haugset; Holmen, Yangchen Dhondup; Aukrust, Pål; Yndestad, Arne & Vinge, Leif Erik (2014). Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension. PLOS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0104407
• Sandanger, Øystein; Ranheim, Trine; Vinge, Leif Erik; Bliksøen, Marte; Alfsnes, Katrine; Finsen, Alexandra; Dahl, Christen Peder; Askevold, Erik Tandberg; Florholmen, Geir; Christensen, Geir Arve; Fitzgerald, Katherine A.; Lien, Egil; Valen, Guro; Espevik, Terje; Aukrust, Pål & Yndestad, Arne (2013). The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovascular Research (CVR).  ISSN 0008-6363.  99(1), s 164- 174 . doi: 10.1093/cvr/cvt091
• Askevold, Erik Tandberg; Gullestad, Lars; Aakhus, Svend; Ranheim, Trine; Tønnessen, Theis; Solberg, Ole Geir; Aukrust, Pål & Ueland, Thor (2012). Secreted Wnt Modulators in Symptomatic Aortic Stenosis. Journal of the American Heart Association.  ISSN 2047-9980.  1(6) . doi: 10.1161/JAHA.112.002261
• Dahl, Tuva Børresdatter; Bermudez, Beatriz; Ranheim, Trine; Otterdal, Kari; Holm, Sverre; Biessen, Erik A; Halvorsen, Bente & Aukrust, Pål (2012). Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis. Journal of Clinical Lipidology.  ISSN 1933-2874.  7(6), s 697- 707 . doi: 10.2217/CLP.12.71
• Hol, Johanna; Otterdal, Kari; Breland, Unni Mathilde; Stang, Espen; Pedersen, Turid Margrethe; Hagelsteen, Kathrine; Ranheim, Trine; Kasprzycka, Monika; Halvorsen, Bente; Haraldsen, Guttorm & Aukrust, Pål (2012). Statins Affect the Presentation of Endothelial Chemokines by Targeting to Multivesicular Bodies. PLOS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0040673
• Smedbakken, Linda Merete; Halvorsen, Bente; Daissormont, Isabelle; Ranheim, Trine; Michelsen, Annika; Skjelland, Mona; Sagen, Ellen Lund; Folkersen, Lasse; Krohg-Sørensen, Kirsten; Russell, David; Holm, Sverre; Ueland, Thor; Fevang, Børre; Hedin, Ulf; Yndestad, Arne; Gullestad, Lars; Hansson, Göran K; Biessen, Erik A & Aukrust, Pål (2012). Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization. Atherosclerosis.  ISSN 0021-9150.  224(1), s 266- 273 . doi: 10.1016/j.atherosclerosis.2012.06.071
• Yndestad, Arne; Finsen, Alexandra; Ueland, Thor; Husberg, Cathrine; Dahl, Christen Peder; Øie, Erik; Vinge, Leif Erik; Sjaastad, Ivar; Sandanger, Øystein; Ranheim, Trine; Dickstein, Kenneth; Kjekshus, John; Damås, Jan Kristian; Fiane, Arnt E; Hilfiker-Kleiner, Denise; Lipp, Martin; Gullestad, Lars; Christensen, Geir Arve & Aukrust, Pål (2012). The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure. PLOS ONE.  ISSN 1932-6203.  7(3) . doi: 10.1371/journal.pone.0033038
• Dahl, Tuva Børresdatter; Ranheim, Trine; Holm, Sverre; Berge, Rolf Kristian; Aukrust, Pål & Halvorsen, Bente (2011). Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages. European Journal of Clinical Investigation.  ISSN 0014-2972.  41(10), s 1098- 1104 . doi: 10.1111/j.1365-2362.2011.02515.x
• Cameron, Jamie; Ranheim, Trine; Halvorsen, Bente; Kulseth, Mari Ann; Leren, Trond Paul & Berge, Knut Erik (2010). Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C. Atherosclerosis.  ISSN 0021-9150.  209(1), s 163- 166 . doi: 10.1016/j.atherosclerosis.2009.08.039
• Dahl, Tuva Børresdatter; Haukeland, John Willy; Yndestad, Arne; Ranheim, Trine; Gladhaug, Ivar Prydz; Damås, Jan Kristian; Haaland, Therese Kristina; Løberg, Else Marit; Arntsen, Borghild M; Birkeland, Kåre I.; Bjøro, Kristian; Ulven, Stine Marie; Zbigniew, Konopski; Nebb, Hilde Irene; Aukrust, Pål & Halvorsen, Bente (2010). Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  95(6), s 3039- 3047 . doi: 10.1210/jc.2009-2148
• Michelsen, Annika; Rathcke, CN; Skjelland, Mona; Holm, Sverre; Ranheim, Trine; Krohg-Sørensen, Kirsten; Klingvall, Marit Fodnes; Brosstad, Frank Roger; Øie, Erik; Vestergaard, H.; Aukrust, Pål & Halvorsen, Bente (2010). Increased YKL-40 expression in patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  211(2), s 589- 595 . doi: 10.1016/j.atherosclerosis.2010.02.035
• Holla, Øystein Lunde; Kulseth, Mari Ann; Berge, Knut Erik; Leren, Trond Paul & Ranheim, Trine (2009). Nonsense-mediated decay of human LDL receptor mRNA. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  69(3), s 409- 417 . doi: 10.1080/00365510802707163
• Tveten, Kristian; Ranheim, Trine; Berge, Knut Erik; Leren, Trond Paul & Kulseth, Mari Ann (2009). The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR. Acta Biochimica et Biophysica Sinica.  ISSN 0582-9879.  41(3), s 246- 255 . doi: 10.1093/abbs/gmp008
• Cameron, Jamie; Holla, Øystein Lunde; Berge, Knut Erik; Kulseth, Mari Ann; Ranheim, Trine; Leren, Trond Paul & Lærdahl, Jon Kristen (2008). Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion. The FEBS Journal.  ISSN 1742-464X.  275(16), s 4121- 4133 . doi: 10.1111/j.1742-4658.2008.06553.x
• Cameron, Jamie; Holla, Øystein Lunde; Lærdahl, Jon Kristen; Kulseth, Mari Ann; Ranheim, Trine; Rognes, Torbjørn; Berge, Knut Erik & Leren, Trond Paul (2008). Characterization of novel mutations in the catalytic domain of the PCSK9 gene. Journal of Internal Medicine.  ISSN 0954-6820.  263(4), s 420- 431 . doi: 10.1111/j.1365-2796.2007.01915.x

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• Sokolova, Marina; Sjaastad, Ivar; Alfsnes, Katrina; Louwe, Mieke; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bliksøen, Martha; Lien, Egil; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2014). NLRP3 inflammasome promote myocardial remodeling during diet-induced obesity.
• Sandanger, Øystein; Ranheim, Trine; Vinge, Leif Erik; Bliksøen, Marte; Valen, Guro; Aukrust, Pål & Yndestad, Arne (2013). A role for NLRP3 inflammasome in acute myocardial ischmia-reperfusion injury? Reply. Cardiovascular Research (CVR).  ISSN 0008-6363.  99(1), s 226- 227 . doi: 10.1093/cvr/cvt130
• Bliksøen, Marte; Mariero, Lars Henrik; Ohm, Ingrid Kristine; Haugen, Fred; Yndestad, Arne; Solheim, Svein; Seljeflot, Ingebjørg; Ranheim, Trine; Andersen, Geir Øystein; Aukrust, Pål; Valen, Guro & Vinge, Leif Erik (2012). Increased circulating mitochondrial DNA after myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  158(1), s 132- 134 . doi: 10.1016/j.ijcard.2012.04.047
• Ranheim, Trine; Flottorp, Signe Agnes; Austvoll-Dahlgren, Astrid Trobe & Johansen, Marit (2010). Effekter av tverrfaglige ambulante tjenester for pasienter med kroniske sykdommer. Rapport fra Kunnskapssenteret. 7/2010.
• Holte, Hilde H; Ranheim, Trine & Flottorp, Signe Agnes (2009). Effekt av rehabilitering på deltaking sosialt og i samfunnet. Rapport fra Kunnskapssenteret. 27/2009. Full text in Research Archive. Show summary

  Helsedirektoratet ved Avdeling for rehabilitering og sjeldne funksjonshem­ninger hen­vendte seg til Kunnskapssenteret i januar 2008 med spørsmål om å få utarbeidet en oversikt over kunnskap om effekten av (re)ha­bi­li­te­­ring, når (re)habilitering er for­stått som tverr­faglige og tverr­sek­torielle til­tak og prosesser med utgangspunkt i bru­kerens egne mål og behov for å oppnå best mulig funksjons- og mestringsevne, selv­stendighet og deltakelse sosialt og i samfunnet.

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