Viola Lobert

Image of Viola Lobert
Norwegian version of this page
Mobile phone 98850060
Room K06-011
Visiting address Ullernchausseen 70 Institute for Cancer Research
Postal address Postboks 4950 0424 OSLO
Other affiliations Department of Education (Student)

I am interested in developmental signaling pathways and how they are dysregulated in cancer. I use mini-organs, so-called organoids, to model the role of tumour suppressors in development and cancer. I am especially interested in using high resolution imaging techniques to answer my biological questions.


  • Hurem, Selma; Gomes, Tania; Brede, Dag Anders; Mayer, Ian; Lobert, Viola; Mutoloki, Stephen; Gutzkow, Kristine Bjerve; Teien, Hans-Christian; Oughton, Deborah Helen; Alestrøm, Peter & Lyche, Jan Ludvig (2018). Gamma irradiation during gametogenesis in young adult zebrafish causes persistent genotoxicity and adverse reproductive effects. Ecotoxicology and Environmental Safety.  ISSN 0147-6513.  154, s 19- 26 . doi: 10.1016/j.ecoenv.2018.02.031 Full text in Research Archive. Show summary
  • O'Farrell, Fergal; Lobert, Viola; Sneeggen, Marte; Jain, Ashish; Katheder, Nadja Sandra; Wenzel, Eva; Schultz, Sebastian; Tan, Kia Wee; Brech, Andreas; Stenmark, Harald Alfred & Rusten, Tor Erik (2017). Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. Nature Cell Biology.  ISSN 1465-7392.  19, s 1412- 1423 . doi: 10.1038/ncb3631
  • Halsne, Ruth; Tandberg, Julia Isabel; Lobert, Viola; Østby, Gunn Charlotte; Thoen, Even; Ropstad, Erik & Verhaegen, Steven (2016). Effects of perfluorinated alkyl acids on cellular responses of MCF-10A mammary epithelial cells in monolayers and on acini formation in vitro. Toxicology Letters.  ISSN 0378-4274.  259(30), s 95- 107 . doi: 10.1016/j.toxlet.2016.08.004
  • Holland, Petter; Knævelsrud, Helene; Søreng, Kristiane; Mathai, Benan John; Lystad, Alf Håkon; Pankiv, Serhiy; Bjørndal, Gunnveig Toft; Schultz, Sebastian; Lobert, Viola; Chan, Robin B; Zhou, Bowen; Liestøl, Knut; Carlsson, Sven R; Melia, Thomas J; Di Paolo, Gilbert & Simonsen, Anne (2016). HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nature Communications.  ISSN 2041-1723.  7 . doi: 10.1038/ncomms13889 Full text in Research Archive.
  • Lobert, Viola; Mouradov, Dmitri & Heath, Joan K. (2016). Focusing the Spotlight on the Zebrafi sh Intestine to Illuminate Mechanisms of Colorectal Cancer. Advances in Experimental Medicine and Biology.  ISSN 0065-2598.  916, s 411- 437
  • Oppelt, Angela; Haugsten, Ellen Margrethe; Zech, Tobias; Danielsen, Håvard Emil; Sveen, Anita; Lobert, Viola Helene; Skotheim, Rolf Inge & Wesche, Jørgen (2014). PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochemical Journal.  ISSN 0264-6021.  461(3), s 383- 390 . doi: 10.1042/BJ20140132
  • Oppelt, Angela; Lobert, Viola Helene; Haglund, Kaisa; Mackey, Ashley M.; Rameh, Lucia E.; Liestøl, Knut; Schink, Kay Oliver; Pedersen, Nina Marie; Wenzel, Eva; Haugsten, Ellen Margrethe; Brech, Andreas; Rusten, Tor Erik; Stenmark, Harald Alfred & Wesche, Jørgen (2013). Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Reports.  ISSN 1469-221X.  14(1), s 57- 64 . doi: 10.1038/embor.2012.183
  • Lobert, Viola Helene & Stenmark, Harald Alfred (2012). The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain. Journal of Cell Science.  ISSN 0021-9533.  125(1), s 29- 36 . doi: 10.1242/jcs.088310
  • Lobert, Viola Helene & Stenmark, Harald (2011). Cell Polarity and Migration: Emerging Role for the Endosomal Sorting Machinery. Physiology.  ISSN 1548-9213.  26(3), s 171- 180 . doi: 10.1152/physiol.00054.2010
  • Malerød, Lene; Pedersen, Nina Marie; Wegner, Catherine E Sem; Lobert, Viola Helene; Leithe, Edward; Brech, Andreas; Rivedal, Edgar; Liestøl, Knut & Stenmark, Harald (2011). Cargo-Dependent Degradation of ESCRT-I as a Feedback Mechanism to Modulate Endosomal Sorting. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  12(9), s 1211- 1226 . doi: 10.1111/j.1600-0854.2011.01220.x
  • Lobert, Viola Helene; Brech, Andreas; Pedersen, Nina Marie; Wesche, Jørgen; Oppelt, Angela; Malerød, Lene & Stenmark, Harald (2010). Ubiquitination of alpha 5 beta 1 lntegrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-lntegrin Complexes. Developmental Cell.  ISSN 1534-5807.  19(1), s 148- 159 . doi: 10.1016/j.devcel.2010.06.010
  • Rodahl, Lina; Stuffers, Susanne; Lobert, Viola Helene & Stenmark, Harald Alfred (2009). The role of ESCRT proteins in attenuation of cell signalling. Biochemical Society Transactions.  ISSN 0300-5127.  37, s 137- 142 . doi: 10.1042/BST0370137

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  • Griffiths, Gareth Wyn; Müller, Ference; Ledin, Johan; Patton, E. Elizabeth; Gjøen, Tor; Lobert, Viola; Winther-Larsen, Hanne Cecilie; Mullins, Mary; Joly, Jean-Stephane; Weltzien, Finn-Arne; Press, Charles McLean & Alestrøm, Peter (2016). Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo. Zebrafish.  ISSN 1545-8547.  13(2), s 132- 137 . doi: 10.1089/zeb.2015.1212
  • Hurem, Selma; Gomes, Tania; Brede, Dag Anders; Hansen, Elisabeth Lindbo; Lobert, Viola; Martin, Leonardo M; Mayer, Ian; Mutoloki, Stephen; Salbu, Brit; Teien, Hans-Christian; Oughton, Deborah Helen; Aleström, Peter & Lyche, Jan Ludvig (2016). Gamma radiation causes adverse reproductive and heritable effects in zebrafish.
  • Lobert, Viola Helene; Bruun, Jarle; Abrahamsen, Hilde; Lothe, Ragnhild A; Stenmark, Harald Alfred; Kolberg, Matthias & Campsteijn, Coen (2013). Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene beta-catenin. EMBO Reports.  ISSN 1469-221X.  14(1), s 10- 11 . doi: 10.1038/embor.2012.188

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Published May 14, 2019 12:15 PM - Last modified Sep. 19, 2019 12:01 PM

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