Schizophrenia is now recognized as one of the major public health concerns, as it is associated with a reduced life quality, a shorter life expectancy, and a huge financial burden. Accumulating studies have shown an estimated 80% heritability and brain alternations in schizophrenia. Here, we applying integrated approaches on genome-wide association datasets, Norwegian biobank, and registry samples to evaluate the associations among genetic factors, brain morphology, and schizophrenia, as well as to exploring the biological mechanism underlying these associations.
- PhD 2014-2019, Psychiatry and mental health, Peking University
- psychiatric genetics
- brain imaging genetics
- brain development
- precision medicine
O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco & Cheng, Weiqiu [Show all 16 contributors for this article] (2021). Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes. Biological Psychiatry. ISSN 0006-3223.
Shadrin, Alexey A.; Kaufmann, Tobias; van der Meer, Dennis; Palmer, Clare E.; Makowski, Carolina & Loughnan, Robert [Show all 22 contributors for this article] (2021). Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. NeuroImage. ISSN 1053-8119. 244, p. 1–8. doi: 10.1016/j.neuroimage.2021.118603. Full text in Research Archive
Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Show all 20 contributors for this article] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), p. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Full text in Research Archive