Kristian Holm

Senior Engineer - Department of Transplantation
Image of Kristian Holm
Norwegian version of this page
Visiting address Sognsvannsveien 20 OUS Rikshospitalet 0372 Oslo
Postal address Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo
Tags: psc, nopsc


  • Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Show all 13 contributors for this article] (2022). A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32773.
  • Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Stiksrud, Birgitte; Lorvik, Kristina Berg; Seljeflot, Ingebjørg & Hansen, Simen Hyll [Show all 13 contributors for this article] (2022). Probiotics to HIV-infected immunological nonresponders: Altered mucosal immunity and microbial diversity restricted to ileum. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 89(1), p. 77–86. doi: 10.1097/QAI.0000000000002817.
  • Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian & Barratt-Due, Andreas [Show all 37 contributors for this article] (2022). Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations. Journal of Internal Medicine. ISSN 0954-6820. 291(6), p. 801–812. doi: 10.1111/joim.13458.
  • Zimmer, Christine L.; von Seth, Erik; Buggert, Marcus; Strauss, Otto; Hertwig, Laura & Nguyen, Son [Show all 24 contributors for this article] (2021). A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells. Science Translational Medicine. ISSN 1946-6234. doi: 10.1126/scitranslmed.abb3107. Full text in Research Archive
  • Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter & Yang, Kuan [Show all 17 contributors for this article] (2021). NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-98820-0. Full text in Research Archive
  • Jiang, Xiaojun; Bergquist, Annika; Löscher, Britt-Sabina; Venkatesh, Geetha; Mold, Jeff E. & Holm, Kristian [Show all 15 contributors for this article] (2021). A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis. Science Translational Medicine. ISSN 1946-6234. 13(582). doi: 10.1126/scitranslmed.abb0036.
  • Awoyemi, Ayodeji Olawale; Mayerhofer, Christiane Caroline; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D. & Lappegård, Knut Tore [Show all 23 contributors for this article] (2021). Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine. ISSN 2352-3964. 70. doi: 10.1016/j.ebiom.2021.103511. Full text in Research Archive
  • Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Lorvik, Kristina Berg; Seljeflot, Ingebjørg; Hansen, Simen Hyll & Holm, Kristian [Show all 13 contributors for this article] (2020). HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiaa714. Full text in Research Archive
  • Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Show all 22 contributors for this article] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Full text in Research Archive
  • Mayerhofer, Christiane Caroline; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale & Vestad, Beate [Show all 17 contributors for this article] (2020). Low fibre intake is associated with gut microbiota alterations in chronic heart failure. ESC Heart Failure. ISSN 2055-5822. 7(2), p. 456–466. doi: 10.1002/ehf2.12596. Full text in Research Archive
  • Gelpi, Marco; Vestad, Beate; Hansen, Simen Hyll; Holm, Kristian; Drivsholm, Ninna & Götz, Alexandra [Show all 17 contributors for this article] (2020). Impact of human immunodeficiency virus-related gut microbiota alterations on metabolic comorbid conditions. Clinical Infectious Diseases. ISSN 1058-4838. 71(8), p. e359–e367. doi: 10.1093/cid/ciz1235. Full text in Research Archive
  • Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin & Otterdal, Kari [Show all 14 contributors for this article] (2020). Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.574500. Full text in Research Archive
  • Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Show all 18 contributors for this article] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, p. 1–9. doi: 10.1038/s41598-020-62261-y. Full text in Research Archive
  • Fretheim, Håvard Halland; Chung, Brian K.; Didriksen, Henriette; Bækkevold, Espen Sønderaal; Midtvedt, Øyvind & Brunborg, Cathrine [Show all 18 contributors for this article] (2020). Fecal Microbiota Transplantation in Systemic Sclerosis: A Double-Blind, Placebo-Controlled Randomized Pilot Trial. PLOS ONE. ISSN 1932-6203. 15:e0232739(5), p. 1–14. doi: 10.1371/journal.pone.0232739. Full text in Research Archive
  • Larsen, Christopher Storm; Myhr, Kjell-Morten; Farbu, Elisabeth; Midgard, Rune; Nyquist, Kaja Beate & Broch, Line [Show all 14 contributors for this article] (2019). Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis – a pilot trial. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. 5(4), p. 1–13. doi: 10.1177/2055217319888767. Full text in Research Archive
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Show all 18 contributors for this article] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, p. 1–10. doi: 10.1038/s41598-018-35367-7. Full text in Research Archive
  • Arnbjerg, Caroline J; Vestad, Beate; Hov, Johannes Espolin Roksund; Pedersen, Karin K; Jespersen, Sofie & Johannesen, Helle H [Show all 15 contributors for this article] (2018). Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 78(4), p. 450–457. doi: 10.1097/QAI.0000000000001693.
  • Larsen, Christopher Storm; Stiksrud, Birgitte; Eriksen, Carsten; Eriksen, C.; Nowak, Piotr & Nowak, P. [Show all 14 contributors for this article] (2018). Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals. AIDS (London). ISSN 0269-9370. 33(4), p. 645–653. doi: 10.1097/QAD.0000000000002087. Full text in Research Archive
  • Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian & Kummen, Martin [Show all 17 contributors for this article] (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-25168-3. Full text in Research Archive
  • Alberts, R; de Vries, EMG; Goode, EC; Jiang, Xiaojun; Sampaziotis, Fotios & Rombouts, K [Show all 50 contributors for this article] (2017). Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. ISSN 0017-5749. 67(8), p. 1517–1524. doi: 10.1136/gutjnl-2016-313598.
  • Henriksen, Eva Kristine Klemsdal; Viken, Marte K; Wittig, Michael; Holm, Kristian; Folseraas, Trine & Mucha, Sören [Show all 29 contributors for this article] (2017). HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA. ISSN 2059-2302. 90(4), p. 228–233. doi: 10.1111/tan.13076.
  • Weismüller, Tobias J.; Trivedi, Palak J.; Bergquist, Annika; Imam, Mohamad; Lenzen, Henrike & Ponsioen, Cyriel Y. [Show all 59 contributors for this article] (2017). Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 152(8), p. 1975–1984.e8. doi: 10.1053/j.gastro.2017.02.038.
  • Tronstad, Rune Rose; Kummen, Martin; Holm, Kristian; Volkmann, Hilde Løland Von; Anmarkrud, Jarl Andreas & Høivik, Marte Lie [Show all 13 contributors for this article] (2017). Guanylate cyclase C activation shapes the intestinal microbiota in patients with familial diarrhea and increased susceptibility for Crohn's disease. Inflammatory Bowel Diseases. ISSN 1078-0998. 23(10), p. 1752–1761. doi: 10.1097/MIB.0000000000001264.
  • Schrumpf, Elisabeth; Kummen, Martin; Valestrand, Cecilie; Greiner, Thomas U; Holm, Kristian & Arulampalam, Velmurugesam [Show all 13 contributors for this article] (2017). The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation. Journal of Hepatology. ISSN 0168-8278. 66(2), p. 382–389. doi: 10.1016/j.jhep.2016.09.020. Full text in Research Archive
  • Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Kaveh, Fatemeh; Holm, Kristian; Hamm, David & Olweus, Johanna [Show all 14 contributors for this article] (2017). Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. Journal of Hepatology. ISSN 0168-8278. 66(1), p. 116–122. doi: 10.1016/j.jhep.2016.09.002.
  • Gabrielsen, Ingvild; Viken, Marte K; Amundsen, Svanstrøm Silja; Helgeland, Hanna; Holm, Kristian & Flåm, Siri Tennebø [Show all 7 contributors for this article] (2016). Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus. Genes and Immunity. ISSN 1466-4879. 17(7), p. 406–411. doi: 10.1038/gene.2016.39.
  • Gabrielsen, Ingvild; Amundsen, Svanstrøm Silja; Helgeland, Hanna; Flåm, Siri Tennebø; Hatinoor, Nimo & Holm, Kristian [Show all 8 contributors for this article] (2016). Genetic risk variants for autoimmune diseases that influence gene expression in thymus. Human Molecular Genetics. ISSN 0964-6906. 25(14), p. 3117–3124. doi: 10.1093/hmg/ddw152.
  • Wang, Jun; Thingholm, Louise B.; Skiecevičienė, Jurgita; Rausch, Philipp; Kummen, Martin & Hov, Johannes Espolin Roksund [Show all 39 contributors for this article] (2016). Genome-wide association analysis identifies variation in Vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics. ISSN 1061-4036. 48(11), p. 1396–1406. doi: 10.1038/ng.3695.
  • Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Frydenlund, Didrik Søli; Holm, Kristian; Paulsen, Vemund & Michelsen, Annika [Show all 23 contributors for this article] (2016). A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients with Common Variable Immunodeficiency. American Journal of Gastroenterology. ISSN 0002-9270. 111(10), p. 1467–1475. doi: 10.1038/ajg.2016.329.
  • Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika & Osnes, Liv T. N. [Show all 21 contributors for this article] (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology. ISSN 1933-0219. doi: 10.1038/mi.2016.18.
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette & Høivik, Marte [Show all 14 contributors for this article] (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. ISSN 0017-5749. 66(4), p. 611–619. doi: 10.1136/gutjnl-2015-310500.
  • Kevans, David; Tyler, Andrea D.; Holm, Kristian; Jørgensen, Kristin Kaasen; Vatn, Morten H & Karlsen, Tom Hemming [Show all 11 contributors for this article] (2016). Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis. Journal of Crohn's and Colitis. ISSN 1873-9946. 10(3), p. 330–337. doi: 10.1093/ecco-jcc/jjv204.
  • Liaskou, Evaggelia; Henriksen, Eva Kristine Klemsdal; Holm, Kristian; Kaveh, Fatemeh; Hamm, D & Fear, Janine [Show all 13 contributors for this article] (2016). High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires. Hepatology. ISSN 0270-9139. 63(5), p. 1608–1619. doi: 10.1002/hep.28116.
  • Nowak, Piotr; Trøseid, Marius; Avershina, Ekaterina; Barqasho, Babilonia; Neogi, Ujjwal & Holm, Kristian [Show all 12 contributors for this article] (2015). Gut microbiota diversity predicts immune status in HIV-1 infection. AIDS (London). ISSN 0269-9370. 29(18), p. 2409–2418. doi: 10.1097/QAD.0000000000000869.
  • Stiksrud, Birgitte; Nowak, Piotr; Nwosu, Felix Chinweije; Kvale, Dag; Thalme, Anders & Sönnerborg, Anders [Show all 15 contributors for this article] (2015). Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 70(4), p. 329–337. doi: 10.1097/QAI.0000000000000784.
  • Hov, Johannes Espolin Roksund; Zhong, Huanzi; Qin, Bincai; Anmarkrud, Jarl Andreas; Holm, Kristian & Franke, Andre [Show all 8 contributors for this article] (2015). The influence of the autoimmunity-associated ancestral HLA haplotype AH8.1 on the human gut microbiota: A cross-sectional study. PLOS ONE. ISSN 1932-6203. 10:e0133804(7). doi: 10.1371/journal.pone.0133804.
  • Ellinghaus, David; Folseraas, Trine; Holm, Kristian; Ellinghaus, Eva; Melum, Espen & Balschun, Tobias [Show all 37 contributors for this article] (2013). Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology. ISSN 0270-9139. 58(3), p. 1074–1083. doi: 10.1002/hep.25977.
  • Folseraas, Trine; Melum, Espen; Rausch, Philipp; Juran, Brian D.; Ellinghaus, Eva & Shiryaev, Alexey [Show all 40 contributors for this article] (2012). Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology. ISSN 0168-8278. 57(2), p. 366–375. doi: 10.1016/j.jhep.2012.03.031.
  • Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J.; Gotthardt, Daniel & Offner, Felix A. [Show all 43 contributors for this article] (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics. ISSN 1061-4036. 43(1), p. 17–19. doi: 10.1038/ng.728.
  • Holm, Kristian; Melum, Espen; Franke, Andre & Karlsen, Tom Hemming (2010). SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels. BMC Bioinformatics. ISSN 1471-2105. 11. doi: 10.1186/1471-2105-11-600.
  • Bergestuen, Deidi Ann; Aabakken, Lars; Holm, K; Vatn, Morten H & Thiis-Evensen, Espen (2009). Small intestinal neuroendocrine tumors: Prognostic factors and survival. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44(9), p. 1084–1091. doi: 10.1080/00365520903082432.

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  • Meyer-Myklestad, Malin Holm; Kummen, Martin; Stiksrud, Birgitte; Holm, Kristian; Dyrhol-Riise, Anne Ma & Kvale, Dag [Show all 11 contributors for this article] (2019). ALTERED GUT IMMUNITY IN IMMUNOLOGICAL NONRESPONDERS PARTLY RESTORED BY PROBIOTICS.
  • Jørgensen, Silje Fjellgård; Holm, Kristian; Macpherson, Magnhild Eide; Larsen, Christopher Storm; Kummen, Martin & Fevang, Børre [Show all 8 contributors for this article] (2019). Selective IgA deficiency in humans is associated with reduced gut microbial diversity. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 143(5), p. 1969–1971.e11. doi: 10.1016/j.jaci.2019.01.019.
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte & Trøseid, Marius [Show all 12 contributors for this article] (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
  • Wittig, Michael; Anmarkrud, Jarl Andreas; Forster, Michael; Ellinghaus, Eva; Holm, Kristian & Wienbrandt, L [Show all 12 contributors for this article] (2013). In solution HLA capture and high-resolution NGS-based typing method and an automated, integrated analysis framework.

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Published Jan. 28, 2016 8:21 AM - Last modified Jan. 28, 2016 9:30 PM