Program
09:00 Coffee and registration.
09:15 Introduction.
Practical information by Kaja Nordengen.
Session 1 - Efflux routes
09:20 CSF efflux through the nasal route.
Iben Lundgaard.
09:50 Inner ear dynamics after intrathecal contrast administration.
Benedicte Falkenberg-Jensen.
10:10 Current knowledge of Meningeal Lymphatic Vessels.
Cesar Vera.
10:30 Determination of glymphatic clearance with population pharmacokinetic modelling.
Markus Hovd.
10:50 - 11:00 Break
Session 2 - Preclinical models
11:00 Inversion of intracranial CSF tracer efflux and influx dynamics by
altering anesthesia or age in mouse.
Jari Jukkola.
10:20 Preclinical MRI Insights into Brain Fluid and Glymphatic Function.
Yuki Mori.
12:00 - 13:00 Lunch
Session 3 - Glymphatics clearance in Parkinson’s disease
13:00 Exploring the therapeutic potential of the glymphatic system in the clearance of pathological alpha-synuclein from the brain.
Ian Harrison.
13:30 Pathways of CSF flow and Clearance in Parkinsons Disease.
A detailed Examination.
Sofie Lysholm Lian.
13:50 AQP4 channel and its Polarization in Parkinson’s Disease:
Insights into Glymphatic System Alterations Across Disease.
Progression.
Gezeme Seferi.
14:10 Experiences as a healthy control and a next of kind to a person with
Parkinson Disease.
Kirsten Valdmanis.
14:30 - 14:50 Break
Session 4 - Modelling CSF flow in disease
14:50 Multi-Scale, Multi-Compartment Coupled Flow-Oxygen Models of
Ischaemic Stroke.
Yun Bing.
15:10 Modelling the impairment of the glymphatic system due to glioma
growth.
Alexandre Poulain.
15:30 In-silico molecular transport in the human intracranial space.
Marius Causemann.
15:50 - 16.15 Break
Session 5 - Methods for modelling CSF flow
16:15 Gonzo - An Intrathecal Contrast-Enhanced MRI Dataset for Tracer Transport
in the Human Brain.
Jørgen Riseth.
16:35 Statistical methods for estimating early glymphatic enrichment.
Are Hugo Pripp.
16:55 In vivo proton magnetic resonance spectroscopy-visible lactate as a noninvasive marker of solute clearance by cerebrospinal fluid movement through the brain.
Kelley Swanberg.
17:15 TBA.
Marie E. Rognes.
17:55 Closing remarks by Kent-Andre Mardal.