Markus Wiedmann is a senior consultant neurosurgeon at Oslo University Hospital and an affiliated researcher at the K.G. Jebsen Centre for Brain Fluid Research.
His work focuses on the interface between cerebrovascular disease and brain fluid dynamics. Coming from a cerebrovascular background, he investigates how changes in vascular architecture and pulsatility influence cerebrospinal fluid transport and waste clearance in the human brain. Using patient models such as Moyamoya angiopathy and chronic MCA occlusion, his research integrates advanced glymphatic MRI, 15O-water PET, and biomarker profiling to establish mechanistic links between vascular dysfunction, impaired clearance, and clinical symptoms such as cognitive decline and fatigue. This complements Professor Per Kristian Eide’s group by adding a vascular perspective to brain fluid research, strengthening the translational framework of the Centre. Ultimately, the aim is to develop diagnostic and therapeutic tools that can be implemented in clinical practice to improve outcomes for patients with cerebrovascular and neurodegenerative disease.