A Translational Research Program for the Development of New Strategies for Immunotherapy Against Cancer
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Feb. 18, 2019 1:50 PM
Educated NK cells expressing self-MHC specific inhibitory killer cell immunoglobulin-like receptors (KIR) accumulate granzyme B in dense-core secretory lysosomes that converge close to the centrosome. Our results indicate an intrinsic role for lysosomal remodeling in NK cell education.