The primary objective of our centre is to translate recent huge advances in the basic understanding of the pathogenesis of coeliac disease to the clinic – to improve disease diagnostics, to implement novel treatments and to identify new therapeutic targets for this common disease.
The secondary objective is to become a clinical research site at the international forefront which will provide optimal patient care and which will be a unique training site for basic scientists and clinicians.
Is regular gluten free diet sufficient to curb all anti-gluten immunity?
Feb. 17, 2021 10:52 PM
Proteomics analysis of intestinal tissue biopsies finds that some patients with celiac disease considered to be well treated by regular gluten free diet have ongoing low-level inflammation in the intestine suggestive of ongoing low-level anti-gluten immunity. These patients developed strong intestinal response following 14 -day gluten challenge. We are now investigating whether some patients may still have activated gluten-specific T-cells despite long-term gluten free diet.
Did you miss our presentation at Coeliac UK?
Oct. 21, 2020 9:24 AM
In February, our research was presented on social media platforms and at the website of Coeliac UK. We also participated in a Q&A, answering questions from patients and the public.
- Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort Mar. 19, 2021 10:00 AM
- A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding Mar. 17, 2021 10:00 AM
- Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning Apr. 2, 2021 11:00 AM