Publication in Nature Methods by PhD student Ida Lindeman and colleagues
PhD student Ida Lindeman has performed part of her PhD work in Cambridge, Sarah Teichmann's laboratory, as part of a researcher exchange program to develop world leading research at UiO. Her work has now been published in Nature Methods.
Here she developed a new bioinformatic tool (BraCeR) that can reconstruct sequences of rearranged and expressed B-cell receptor genes from single-cell RNA-seq data. Lindeman will use her new tool to decipher the full transcriptomic profile of clonal B cells involved in the immune response towards gluten.
The project has been a collaborative project between the Teichmann lab at the Wellcome Sanger Institute in Cambridge and the Sollid lab at the University of Oslo/Oslo University Hospital.
Publication: BraCeR: B-cell-receptor reconstruction and clonality inference from single-cell RNA-seq. Nature Methods, vol. 15, p. 563–565 (2018).