Genetics of autoimmunity and cancer
Our research is focused on understanding the genetic mechanisms of cancer and autoimmune diseases.
We investigate autoimmune diseases (including rheumatoid arthritis, type 1 diabetes and multiple sclerosis) and cancer (mainly breast cancer) through studies of DNA, RNA, proteins and cells.
We also investigate whether there is immunogenetic evidence for an autoimmune component in other phenotypes like ME/CFS and low back pain with modic changes.
We study large and well-characterized patient cohorts to unravel genetic predisposition, as well as the influence of genetic risk factors on clinical outcome.
Additionally, we explore the relationship between genetic risk polymorphisms and environmental risk factors.
Furthermore, the genetic studies are complemented by functional studies of RNA expression, methylation, miRNA or protein profiles to shed light on the role of the susceptibility genes in the pathogenesis or to identify markers for treatment response.
The group is currently concentrating on three projects: