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Clinical transplantation surgery and experimental immunology

The research group is focused on mechanisms that regulate the immune activity in healthy individuals and in patients suffering for immune related diseases and conditions such as rejection after organ transplantastion, autoimmunity, immunodeficiency, chronic infections and cancer.

About the group

The research group is also working on clinical issues related kidney, liver and pancreas transplantation. Surgical technique, surgical complications, patient- and graft survival, graft function and preservation and donor criteria are important areas of the research Projects.

The main goals in experimental immunology is to map and identify new therapeutic targets. We use biochemical, cellular biological og functional immunological methods to investigate intracellular signal transduction pathways in mainly T cells. Our main goals in clinical transplantation surgery are to improve the prognosis and patient survival in kidney, liver and pancreas recipients and to optimize graft function. We also aim to improve the availability of donor organs by using extended criteria for donor selection and increase the quality of the organs by new preservation Methods.

 

Projects

  • Regulatory T cells in Cancer and Immune-Related Disease
  • Liver transplantation for colorectal liver metastases
  • Clinical and Surgical Aspects of Complications in Kidney Transplantation
  • Regulatory T cells in Immune-Related Disease
  • New Strategies in Medical and Surgical Treatment in Pancreas Transplantation for Severe Diabetes Type I
  • The use of extended criteria donors in liver transplantation
  • ABO-incompatible liver transplantation
  • Liver transplantation as rescue treatment after liver resections and surgical complications after liver surgery

Cooperation

Internal

  • Section for nephrology, Dept. of transplantation medicine, OUS.
  • Institute pathology, UiO/OUS.
  • Section for gastroenterology, Dept. of transplantation medicine, OUS.
  • Norwegian Centre for Molecular Medicine, UiO.
  • Institute of surgerical research, UiO/OUS
  • Norwegian PSC Research Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • K.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo University Hospital, Norway.
  • K.G. Jebsen Centre for Cancer Immunotherapy, University of Oslo, Oslo University Hospital, Norway.
  • Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.

National

  • Department of Obstetrics and Gynecology Haukeland University Hospital, Bergen, Norway
  • Institute of Clinical Medicine, Institute of Internal Medicine University of Bergen, Bergen, Norway
  • Centre of Cancer Biomarkers CCBIO, Department of Clinical Science University of Bergen, Bergen, Norway
  • Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway
  •  

International

  • Department of Transplantation, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Division of Transplantation Surgery, Karolinska University Hospital Huddinge, Solna, Sweden.
  • Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.
  • Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom.

Selected Publications

  • Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM. CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer. J Immunol. 2017 Feb 15;198(4):1729-1739
  • Landsverk OJ, Snir O, Casado RB, Richter L, Mold JE, Réu P, Horneland R, Paulsen V, Yaqub S, Aandahl EM, Øyen OM, Thorarensen HS, Salehpour M, Possnert G, Frisén J, Sollid LM, Baekkevold ES, Jahnsen FL. Antibody-secreting plasma cells persist for decades in human intestine. J Exp Med. 2017 Feb;214(2):309-317.
  • Lindahl JP, Horneland R, Nordheim E, Hartmann A, Aandahl EM, Grzyb K, Haugaa H, Kjøsen G, Åsberg A, Jenssen T. Outcomes in Pancreas Transplantation With Exocrine Drainage Through a Duodenoduodenostomy Versus Duodenojejunostomy. Am J Transplant. 2018 Jan;18(1):154-162.
  • Bujko A, Atlasy N, Landsverk OJB, Richter L, Yaqub S, Horneland R, Øyen O, Aandahl EM, Aabakken L, Stunnenberg HG, Bækkevold ES, Jahnsen FL. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2017 Dec 22.

 

Published Aug. 14, 2018 10:37 AM - Last modified June 11, 2020 1:48 PM

Contact

Group leader

Participants

  • Einar Martin Aandahl
  • Morten Heier Skauby
  • Rune Horneland
  • Trygve Thorsen
  • Ammar Kahn
  • Casper Beiske
  • Kristine Fasting
  • Kushi Kushekhar
Detailed list of participants