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Colorectal Surgery

The research group conducts clinical and molecular genetic (tumor, blood and faeces) studies on colorectal cancer (crc).

About the Group

The colorectal surgery group engages in both clinical and molecular-translational research. The main aims for the translational projects are detection and validation of new diagnostic, prognostic, predictive and monitoring molecular biomarkers, and to make them feasible in the routine clinical setting across laboratories. This effort focuses on achieving a more personalized treatment of patients.

The Group Studies

  • Primary tumor colon - rectum (crc)
  • Early cancer in the rectum
  • Liver Metastases
  • Liquid biopsy at crc
  • Oncological treatment of colorectal cancer
  • Tumor cells in circulation and bone marrow
  • Cultivation / drug testing on living cancer cells

Innovation as a tool towards advanced treatment possibilities, is an important part of the group's effort and several patents have been registered by the group during the past years.

Project Teams

The colorectal surgery research group covers a broad range of topics and consists of two sub-teams.

Clinical Studies

  • Clinical studies on colorectal cancer
    • Survival, prognostic factors, complications to surgery
  • Transanal endoscopic microsurgery (TEM) for localization of large polyps and early rectum cancer
    • Complications. Survival.We have regional function for this patient Group
  • Together with geriatricians (Ass. Prof. Siri Rostoft)
    • Broad geriatric assessment to assess operational risk in the elderly. Completed Phd Siri Rostoft
    • Broad geriatric assessment to identify patients at risk of postoperative complications and investigate whether preoperative interventions give a benefit to these patients. RCT, PhD project, fellow Nina Ommundsen
    • GoSafe - study, multinational, multicenter - functional pre-postoperative function in elderly patients
  • Together with gastromedicines (Ass. Prof. Truls Hauge)
    • Use pancreatic stiffening stents by malignant stenosis in GI tract. Completed PhD project - Lene Larssen
  • Together with health economists (Ass Prof. Eline Aas)
    • Model to estimate the cost and survival of colorectal cancer. Completed PhD project - Pål Joranger
  • Together with radiologist (General Ellen Viktil)
    • MR staging of rectal polyps and early cancer

Collaborators

Internal

  • Molecular Genetics Dept of Molecular Oncology, OUH
    • Prof Ragnhild A Lothe
    • Ass Prof Anita Sveen
    • Prof Rolf I Skotheim
    • Prof Guro E Lind
  • Large-scale genome analyzes, Håvard Danielsen, Dept. Medical Informatics
  • Pathology, Aud Svindland, Tor J Eide, Else Marit Løberg
  • Oncology, Kjell Magne Tveit, Marianne Grønlie Guren, Tormod Kyrre Guren, Olav Dajani
  • Liver Surgery, Bjørn Atle Bjørnbeth, Bård Røsok, Kristoffer Watten Brudvik
  • Radiology, Andreas Abildgaard, Vanja Cengija, Ellen Viktil

External

  • Hospital of Stavanger, Haukeland University Hospital, Porto (Teixeira)
  • Norwegian Cancer Genome Consortium (Ola Myklebost)
  • Collaboration with European and US biotech companies

Selected Publications

  • Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2017) Prognostic markers for colorectal cancer; estimating ploidy and stroma. Ann Oncol (in press)
  • Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J (2017). Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.  Ann Oncol, 28 (5), 1023-1031
  • Labori KJ, Guren MG, Brudvik KW, Røsok BI, Waage A, Nesbakken A, Larsen S, Dueland S, Edwin B, Bjørnbeth BA (2017).  Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival.  Colorectal Dis, 19 (8), 731-738
  • Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
  • Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies. Clin Cancer Res, 24 (4), 794-806
  • Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
  • Multilevel genomics of colorectal cancers with microsatellite instability - clinical impact of JAK1 mutations and consensus molecular subtype 1.  Genome Med, 9 (1), 46
  • Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
  • CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers.  Int J Cancer, 141 (5), 967-976
  • Seeberg LT, Borgen E, Naume B, Wiedswang G. Survival impact of primary tumor lymph node status and circulating tumor cells in pts with colorectal liver metastases. Ann Surg Onc 2017; 24(8):2113-2121
  • Schultz JK, Wallom C, Blecic L et al. One Year Result of the SCANDIV randomized clinical trial.                    Br J Surg 2017;104 (10):1382-1392
  • Chellappa S, Hugenschmidt H, Hageness M et al.  CD8+Tcells that coexpress RORyt.  J Immun                   2017; 189(4):1729-1739
  • 2015 European Society of Coloproctology collaborating group. Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection An international audit by ESCP and S-ECCO. Colorectal Dis. 2017
  • 2015 European Society of Coloproctology collaborating group. The relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. Colorectal Dis. 2017 Mar 6.
Published Aug. 7, 2014 3:05 PM - Last modified Aug. 21, 2019 10:56 AM

Contact

Group leader

Participants

Detailed list of participants