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Colorectal surgery

The research group engages in clinical, molecular genetic (tumor, blood and faeces) and animal experimental studies on colorectal cancer, rectal polyps and pseudomyxoma.

The colorectal surgery group engages in both clinical and molecular-translational research. The main aims for the translational projects are detection and validation of new diagnostic, prognostic, predictive and monitoring molecular biomarkers, and to make them feasible in the routine clinical setting across laboratories. This effort focuses on achieving a more personalized treatment of patients.

The group studies:

  • Primary tumor
  • Liver metastases
  • Peritoneal metastases
  • Exfoliated cells in the peritoneal
  • Tumor cells in the circulation and bone marrow
  • Response to radiotherapy

Innovation as a tool towards advanced treatment possibilities, is an important part of the group's effort and several patents have been registered by the group during the past years.

Project teams

The colorectal surgery research group covers a broad range of topics and consists of four sub-teams:

Selected Publications

  • Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2017) Prognostic markers for colorectal cancer; estimating ploidy and stroma. Ann Oncol (in press)
  • Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J (2017). Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.  Ann Oncol, 28 (5), 1023-1031
  • Labori KJ, Guren MG, Brudvik KW, Røsok BI, Waage A, Nesbakken A, Larsen S, Dueland S, Edwin B, Bjørnbeth BA (2017).  Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival.  Colorectal Dis, 19 (8), 731-738
  • Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
  • Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies. Clin Cancer Res, 24 (4), 794-806
  • Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
  • Multilevel genomics of colorectal cancers with microsatellite instability - clinical impact of JAK1 mutations and consensus molecular subtype 1.  Genome Med, 9 (1), 46
  • Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
  • CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers.  Int J Cancer, 141 (5), 967-976
  • Seeberg LT, Borgen E, Naume B, Wiedswang G. Survival impact of primary tumor lymph node status and circulating tumor cells in pts with colorectal liver metastases. Ann Surg Onc 2017; 24(8):2113-2121
  • Schultz JK, Wallom C, Blecic L et al. One Year Result of the SCANDIV randomized clinical trial.                    Br J Surg 2017;104 (10):1382-1392
  • Chellappa S, Hugenschmidt H, Hageness M et al.  CD8+Tcells that coexpress RORyt.  J Immun                   2017; 189(4):1729-1739
  • 2015 European Society of Coloproctology collaborating group. Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection An international audit by ESCP and S-ECCO. Colorectal Dis. 2017
  • 2015 European Society of Coloproctology collaborating group. The relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. Colorectal Dis. 2017 Mar 6.
Published Aug. 7, 2014 3:05 PM - Last modified Aug. 14, 2018 2:27 PM

Contact

Group leader

Participants

Detailed list of participants