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Functional immunogenetics

We study coeliac disease to understand the interplay between genetic and environmental factors in chronic inflammatory disorders.

Our group is striving to understand what happens when the body's defense from disease, the immune system, directly or indirectly causes harm to the body.

Coeliac disease, rheumatoid arthritis, type 1 (insulin dependent) diabetes, and multiple sclerosis are examples of autoimmune disorders of a chronic inflammatory nature.

We are concentrating on coeliac disease as a model to understand the molecular mechanisms leading to chronic inflammatory disease.

Research in the group has lead to a better understanding of the molecular basis of coeliac disease, but has also revealed general principles of immune regulation that are applicable to other immune mediated disorders.

The research group is part of the K.G. Jebsen Coeliac Disease Research Centre. In the period 2007 - 2017 the research group was part of the Centre for Immune Regulation (CIR), a Centre of Excellence established by the Research Council of Norway.

The research group is located at the Department of Immunology at OUS-Rikshospitalet and is part of the University of Oslo and the Oslo University Hospital.

Projects

  • B cells and the auto-antibody response of coeliac disease.
  • How certain variants of HLA molecules predispose to disease development.
  • Characterisation of how T cells recognise gluten protein, the dietary antigen precipitating coeliac disease.
  • How transglutaminase (TG) 2 mediated post-translational protein modification increases antigenicity.

Representative papers

  • Iversen R, Snir O, Stensland M, Kroll JE, Steinsbø Ø, Korponay-Szabó IR, Lundin KEA, de Souza GA, Sollid LM. Strong clonal relatedness between serum and gut IgA despite different plasma cell origins. Cell Rep. 2017; 20:2357-2367. doi: 10.1016/j.celrep.2017.08.036. PubMed PMID: 28877470.
  • Snir O, Chen X, Gidoni M, du Pré MF, Zhao Y, Steinsbø Ø, Lundin KE, Yaari G, Sollid LM. Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. JCI Insight. 2017;2:e93961. doi:10.1172/jci.insight.9396 PubMed PMID: 28878138.
  • Sollid LM. The roles of MHC class II genes and post-translational modification in celiac disease. Immunogenetics. 2017;69:605-616. doi:10.1007/s00251-017-0985-7. Review. PubMed PMID: 28695286.
  • Roy B, Neumann RS, Snir O, Iversen R, Sandve GK, Lundin KEA, Sollid LM. High-throughput single-cell analysis of B cell receptor usage among autoantigen-specific plasma cells in celiac disease. J Immunol. 2017;199:782-791. doi:10.4049/jimmunol.1700169. PubMed PMID: 28600290.
  • Jabri B, Sollid LM. T cells in celiac disease. J Immunol. 2017;198:3005-3014. doi: 10.4049/jimmunol.1601693. Review. PubMed PMID: 28373482.
  • Sollid LM, Jabri B. Triggers and drivers of autoimmunity: lessons from coeliac disease. Nat Rev Immunol. 2013;13:294-302. doi:10.1038/nri3407. Review. PubMed PMID: 23493116.
Published Mar. 13, 2018 11:38 AM - Last modified June 19, 2019 5:17 PM