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Hepatobiliary malignacies

The Research Group conducts clinical studies and collaborate on translational studies for the treatment of hepatobiliary malignancies.

About the group

We have recently completed two major clinical trials address key issues in liver surgery (ALPPS and laparoscopic liver resection). We are currently putting all our effort in the ASAC trial but continuously work on hypotheses for new RCTs.

Our clinical department is a major provider of surgical specimens necessary for translational research. We therefore focus on close partnership with several key research groups within the field of molecular medicine and tumor Genetics.

The Groups goal is to ensure adequate research infrastructure and financing to make sure that clinical and translational hepatobiliary research activity becomes an integrated part of all aspects of the day to day practice in our Department.

The main aim of the research group is to conduct clinical and translational studies for the treatment of hepatobiliary malignancies. The group has also register-based studies to evaluate and improve patient treatment.


  • The ASAC study, Scandinavian multicentre, placebo-controlled, randomized trial, initiated by our group, investigating the role of aspirin as adjuvant after surgery for colorectal liver metastases, is still recruiting patients and has now 300 of 800 patients included ( The trial is funded by Research Council of Norway, Norwegian Cancer Society, and KLINBEFORSK. 
  • The LIGRO study, Scandinavian multicentre, randomized study investigating portal vein embolization vs ALPPS as a method for promoting growth of liver remnant prior to large liver resections. Primary results are published and sub-analyses are still going on to find the best treatment method.
  • The Oslo COMET trial, single centre, un-blinded, randomized trial comparing laparoscopic and open surgery for colorectal liver metastases. The primary end-point is published and sub-analyses and sub-studies are still going on.
  • The SMART study, is a translational study on colorectal cancer and liver metastases led by Profs Ragnhild Lothe and Arild Nesbakken.



  • Professor Bjørn Edwin Intervensjonssenteret
  • Professor Ragnhild Lothe og Jebsen senteret for tarmkreftforskning ved DNR
  • Professor Kjetil Taskèn, Norwegian Center for Molecular Medicine
  • Professor Kjersti Flatmark, Oslo University Hosptal, DNR


  • All HPB departments at the other University Hospitals in Norway in the ASAC-study (a randomized controlled Multicenter study for the effect of adjuvant ASA following resection of colorectal liver metastases)


  • Scandinavian network on HPB Surgery on several collaborative studies with the University Hospitals in Lund, Gothenburg, Linkøping, Stocholm, Uppsala (Sweden) and Rigshospitalet, Copenhagen (Denmark) through the IHPBA Scandinavian Chapter.
  • Collaboration on the Orange2+ study. PI: Ronald van Dam, Maastricht, The Netherlands
  • Professor Edwin participates in several international multiinstitutional projects and research groups related to MIS.

Selected Publications

(excluding other publications without direct hepatobiliary relevance)

  • Fretland ÅA, Kazaryan AM, Edwin B. Laparoscopic Resection for Liver Malignancies: Do the Elderly Benefit More? J Invest Surg. 2017 Nov 8:1-2.
  • Østrup O, Dagenborg VJ, Rødland EA, Skarpeteig V, Silwal-Pandit L, Grzyb K, Berstad AE, Fretland ÅA, Mælandsmo GM, Børresen-Dale AL, Ree AH, Edwin B, Nygaard V, Flatmark K. Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases. Oncotarget. 2017 Jul 18;8(44):76290-76304.
  • Abu Hilal M, Aldrighetti L, Dagher I, Edwin B, et al. The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation. Ann Surg. 2017 Oct 23.
  • Halls MC, Cherqui D, Taylor MA, Primrose JN, Abu Hilal M; Collaborators of The Difficulty of Laparoscopic Liver Surgery Survey. Are the current difficulty scores for laparoscopic liver surgery telling the whole story? An international survey and recommendations for the future. HPB (Oxford). 2017 Sep 29. pii: S1365-182X(17)30926-7.
  • Aghayan DL, Kazaryan AM, Fretland ÅA, Sahakyan MA, Røsok BI, Bjørnbeth BA, Edwin B. Laparoscopic liver resection for metastatic melanoma. Surg Endosc. 2018 Mar;32(3):1470-1477.
  • Berardi G, Van Cleven S, Fretland ÅA, Barkhatov L, Halls M, Cipriani F, Aldrighetti L, Abu Hilal M, Edwin B, Troisi RI. Evolution of Laparoscopic Liver Surgery from Innovation to Implementation to Mastery: Perioperative and Oncologic Outcomes of 2,238 Patients from 4 European Specialized Centers. J Am Coll Surg. 2017 Nov;225(5):639-649.
  • Cipriani F, Fantini C, Ratti F, Lauro R, Tranchart H, Halls M, Scuderi V, Barkhatov L, Edwin B, et al. Laparoscopic liver resections for hepatocellular carcinoma. Can we extend the surgical indication in cirrhotic patients? Surg Endosc. 2018 Feb;32(2):617-626.
  • Halls MC, Cipriani F, Berardi G, Barkhatov L, Lainas P, Alzoubi M, D'Hondt M, Rotellar F, Dagher I, Aldrighetti L, Troisi RI, Edwin B, Hilal MA. Conversion for Unfavorable Intraoperative Events Results in Significantly Worst Outcomes During Laparoscopic Liver Resection: Lessons Learned From a Multicenter Review of 2861 Cases. Ann Surg. 2017 Jun 2.
  • Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland ÅA, Røsok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjørnbeth BA, Vauthey JN. RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases. Ann Surg. 2017 May 25.
  • Palomar R, Cheikh FA, Edwin B, Fretland Å, Beghdadi A, Elle OJ. A novel method for planning liver resections using deformable Bézier surfaces and distance maps. Comput Methods Programs Biomed. 2017 Jun;144:135-145



Published Aug. 10, 2018 10:34 AM - Last modified Apr. 24, 2020 2:31 PM


Group Leader


  • Bjørn Edwin
  • Umair Majid
  • Anja Kokvoll
  • Bård Røsok
  • Kristoffer Brudvik
  • Kristoffer Lassen
  • Olaug Villanger
  • Sheraz Yaqub
  • Victoria Bringsjord
  • Åsmund Fretland
Detailed list of participants