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Natural Killer cell biology and cell therapy

The group studies the molecular and cellular basis for NK cell differentiation and NK repertoire development in healthy and sick people.

Research in the Malmberg Lab aims at understanding the cellular and molecular mechanism underlying the formation and diversification of human NK cell repertories. A central aspect of these studies is to examine the dynamic tuning of NK cell function by killer cell immunoglobulin-like receptors (KIR) during NK cell differentiation and education.

We develop and use a wide range of single cell technologies, advanced imaging and computational tools to study the regulatory gene circuits involved in shaping the interior of the NK cell with a primary focus on lysosomal signaling. 

In more translational efforts, we seek to implement new insights into NK cell biology in clinical trials for patients with advanced cancer.

Projects

  • INSIDE-NK: Role of inter-organelle communication for effector function
  • DIVERSIFY-NK: Functional diversification of human NK cell repertoires
  • SYNTHETIC KILLER: Genetic engineering of iPSC-derived NK cells for off-the-shelf cell therapy

Cooperation

The research group is mainly based at the Norwegian Radium Hospital and Oslo University Hospital/University of Oslo. However, the group has a node at the Karolinska Institutet and maintain strong interactions with three research networks at the Karolinska Institutet: Immunomodulatory Therapies for Autoimmunity and Cancer (IMTAC), Theme Center for Regenerative Medicine and Center for Infectious Medicine (CIM)

The PI and some group members have double affiliation to CIM.

Resources

We always want to get in touch with highly motivated students and potential post-docs. If you are interested in doing research within our group please contact the group leader Kalle Malmberg.

Published Sep. 5, 2022 10:25 AM - Last modified Sep. 5, 2022 10:26 AM