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Pancreatic Cancer

The research group is an interdisciplinary forum that perform clinical trials and translational research on pancreatic cancer and pancreatic cysts.

About the group

The research group studies the importance of environmental and genetic factors in cancer development, prognostic and predictive factors, early diagnosis, and the efficacy of surgical- oncological- and symptomatic treatment.

Patients with pancreatic tumors treated at Oslo University Hospital is requested consent for storage of biological material and clinical data for use in research. The research group has established a clinical data registry and a biobank with an associated database. T

his ensures a systematic, prospective registration of patients with pancreatic cancer who are being treated at the hospital. Clinical registry contains relevant clinical and histopathological data from routine diagnostics. Biobank database contains the results of clinical and molecular Research.

The research group performs clinical and molecular studies on pancreatic cancer and pancreatic cysts to improve the knowledge about pancreatic cancer and the development of pancreatic cancer, in order to improve the diagnosis, treatment and prognosis for patients with pancreatic cancer.

The main goal is to initiate and perform clinical trials with bolt on translational research aimed at determining the overall benefits of current treatments and evaluating the benefits of newly emerging treatments for pancreatic cancer.

Projects

  • Thematic Pancreatic Tumour Project
  • Norwegian Pancreatic Cancer Trials 1 and 2 (NORPACT)
  • DIPLOMA Trial
  • MINIMUM Study

Cooperation

Internal

  • Professor Bjørn Edwin, Intervention Centre
  • Professor Pål-Dag Line, Department of Transplantation Medicine
  • Professor Ole Christian Lingjærde, Dept. of Computer Science UIO

National

  • Norwegian Gastrointestinal Cancer Group – HPB
  • Norwegian Registry for Gastrointestinal Surgery (Norgast)
  •  

International

  • Bruno Costa Silva, Systems Oncology Group, Champalimaud Research. Lisbon, Portugal
  • Benjamin Haibe-Kains, Princess Margareth Cancer Centre, University Helath Network, Toronto, Canada
  • John J. Hermans, Dept. of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands
  • Professor Marco Del Chiaro, Pancreatic  Surgery Unit, Division of Surgery, Karolinska University Hospital, Stockholm, Sweden

Publications

  • Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery. Kleive D, Berstad AE, Sahakyan MA, Verbeke CS, Naper C, Haugvik SP, Gladhaug IP, Line PD, Labori KJ. J Vasc Surg Venous Lymphat Disord. Epub 2017 Nov 8.
  • Can standardized pathology examination increase the lymph node yield following laparoscopic distal pancreatectomy for ductal adenocarcinoma. Sahakyan MA, Haugvik SP, Røsok BI, Kazaryan AM, Ignjatovic D, Buanes T, Labori KJ, Verbeke CS, Edwin B. HPB (Oxford). 2018 Feb;20(2):175-181.
  • Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) - study protocol for a national multicentre randomized controlled trial. Labori KJ, Lassen K, Hoem D, Grønbech JE, Søreide JA, Mortensen K, Smaaland R, Sorbye H, Verbeke C, Dueland S. BMC Surg. 2017 Aug 25;17(1):94.
  • Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy. Kleive D, Sahakyan MA, Berstad AE, Verbeke CS, Gladhaug IP, Edwin B, Fosby B, Line PD, Labori KJ. Br J Surg. 2017 Oct;104(11):1558-1567.
  • Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: Long-term oncologic outcomes after standard resection. Sahakyan MA, Kim SC, Kleive D, Kazaryan AM, Song KB, Ignjatovic D, Buanes T, Røsok BI, Labori KJ, Edwin B. Surgery. 2017 Oct;162(4):802-811.
  • CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer. Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM. J Immunol. 2017 Feb 15;198(4):1729-1739.
  • Follow-up After Surgery for Pancreatic Ductal Adenocarcinoma: Steps Toward an International Consensus. Labori KJ, Brudvik KW. Pancreas. 2017 Jan;46(1):e2-e3.
  • Perioperative outcomes and survival in elderly patients undergoing laparoscopic distal pancreatectomy. Sahakyan MA, Edwin B, Kazaryan AM, Barkhatov L, Buanes T, Ignjatovic D, Labori KJ, Røsok BI. J Hepatobiliary Pancreat Sci. 2017 Jan;24(1):42-48.
  • Impact of obesity on surgical outcomes of laparoscopic distal pancreatectomy: A Norwegian single-center study. Sahakyan MA, Røsok BI, Kazaryan AM, Barkhatov L, Lai X, Kleive D, Ignjatovic D, Labori KJ, Edwin B. Surgery. 2016 Nov;160(5):1271-1278.
  • Role of laparoscopic enucleation in the treatment of pancreatic lesions: case series and case-matched analysis. Sahakyan MA, Røsok BI, Kazaryan AM, Barkhatov L, Haugvik SP, Fretland ÅA, Ignjatovic D, Labori KJ, Edwin B. Surg Endosc. 2017 May;31(5):2310-2316.
  • Pancreatic Cancer Chemoresistance to Gemcitabine. Amrutkar M, Gladhaug IP. Cancers (Basel). 2017 Nov 16;9(11). pii: E157. Review.
  • Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells. Tjomsland V, Aasrum M, Christoffersen T, Gladhaug IP. Oncotarget. 2017 May 11;8(42):71672-71684.
  • Smoking, alcohol and family history of cancer as risk factors for small intestinal neuroendocrine tumors: a systematic review and meta-analysis. Haugvik SP, Basim Ibrahim I, Hedenström P, Valente R, Hayes AJ, Siuka D, Gladhaug IP, Capurso G. Scand J Gastroenterol. 2017 Aug;52(8):797-802.
  • Role of surgery in pancreatic cancer. Buanes TA. World J Gastroenterol. 2017 Jun 7;23(21):3765-3770.
  • Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study. van Hilst J, de Rooij T, Klompmaker S, Rawashdeh M, Aleotti F, Al-Sarireh B, Alseidi A, Ateeb Z, Balzano G, Berrevoet F, Björnsson B, Boggi U, Busch OR, Butturini G, Casadei R, Del Chiaro M, Chikhladze S, Cipriani F, van Dam R, Damoli I, van Dieren S, Dokmak S, Edwin B, van Eijck C, Fabre JM, Falconi M, Farges O, Fernández-Cruz L, Forgione A, Frigerio I, Fuks D, Gavazzi F, Gayet B, Giardino A, Bas Groot K, Hackert T, Hassenpflug M, Kabir I, Keck T, Khatkov I, Kusar M, Lombardo C, Marchegiani G, Marshall R, Menon KV, Montorsi M, Orville M, de Pastena M, Pietrabissa A, Poves I, Primrose J, Pugliese R, Ricci C, Roberts K, Røsok B, Sahakyan MA, Sánchez-Cabús S, Sandström P, Scovel L, Solaini L, Soonawalla Z, Souche FR, Sutcliffe RP, Tiberio GA, Tomazic A, Troisi R, Wellner U, White S, Wittel UA, Zerbi A, Bassi C, Besselink MG, Abu Hilal M; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS). Ann Surg. 2017 Nov 2. doi: 10.1097/SLA.0000000000002561. [Epub ahead of print]
  • Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors - a multi-institutional study. Sallinen VJ, Le Large TTY, Tieftrunk E, Galeev S, Kovalenko Z, Haugvik SP, Antila A, Franklin O, Martinez-Moneo E, Robinson SM, Panzuto F, Regenet N, Muffatti F, Partelli S, Wiese D, Ruszniewski P, Dousset B, Edwin B, Bartsch DK, Sauvanet A, Massimo F, Ceyhan GO, Gaujoux S; Pancreas 2000 research group. HPB (Oxford). 2017 Oct 5. pii: S1365-182X(17)30939-5.
  • Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes. Kuric E, Seiron P, Krogvold L, Edwin B, Buanes T, Hanssen KF, Skog O, Dahl-Jørgensen K, Korsgren O. Am J Pathol. 2017 Mar;187(3):581-588.
  • Laparoscopic surgery for pancreatic neoplasms: the European association for endoscopic surgery clinical consensus conference. Edwin B, Sahakyan MA, Abu Hilal M, Besselink MG, Braga M, Fabre JM, Fernández-Cruz L, Gayet B, Kim SC, Khatkov IE; EAES Consensus Conference Study Group. Surg Endosc. 2017 May;31(5):2023-2041.
  • Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation. Seleznik GM, Reding T, Peter L, Gupta A, Steiner SG, Sonda S, Verbeke CS, Dejardin E, Khatkov I, Segerer S, Heikenwalder M, Graf R. Gut. 2017 Aug 3. pii: gutjnl-2016-313458.
  • Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer. Malgerud L, Lindberg J, Wirta V, Gustafsson-Liljefors M, Karimi M, Moro CF, Stecker K, Picker A, Huelsewig C, Stein M, Bohnert R, Chiaro MD, Haas SL, Heuchel RL, Permert J, Maeurer MJ, Brock S, Verbeke CS, Engstrand L, Jackson DB, Grönberg H, Löhr JM.Mol Oncol. 2017 Oct;11(10):1413-1429.
  • Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse. Gjelberg HK, Hoem D, Verbeke CS, Eide J, Cooper JG, Molven A. Clin Case Rep. 2017 Apr 6;5(6):761-768.
  • Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC. Strell C, Norberg KJ, Mezheyeuski A, Schnittert J, Kuninty PR, Moro CF, Paulsson J, Schultz NA, Calatayud D, Löhr JM, Frings O, Verbeke CS, Heuchel RL, Prakash J, Johansen JS, Östman A. Br J Cancer. 2017 Jun 27;117(1):65-77.
  • A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer. Omazic B, Ayoglu B, Löhr M, Segersvärd R, Verbeke C, Magalhaes I, Potacova Z, Mattsson J, Terman A, Ghazi S, Albiin N, Kartalis N, Nilsson P, Poiret T, Zhenjiang L, Heuchel R, Schwenk JM, Permert J, Maeurer MJ, Ringden O. J Immunother. 2017 Mar 23.
  • Intraductal papillary mucinous neoplasms of the pancreas: reporting clinically relevant features. Del Chiaro M, Verbeke C. Histopathology. 2017 May;70(6):850-860.

 

Tags: Cancer research
Published Aug. 10, 2018 10:25 AM - Last modified June 4, 2020 1:14 PM

Contact

Group Leader

Participants

  • Ivar Prydz Gladhaug
  • Manoj Amrutkar
  • Trond Buanes
  • Knut Jørgen Labori
  • Anne Waage
  • Astrid M. Dalsgaard
  • Bart Baekelandt
  • Dyre Kleive
  • Elin H. Kure
  • Ingvild Farnes
  • Laxmi Silwal-Pandit
  • Martina L. Skrede
  • Stina M. Stålberg
  • Tore Tholfsen
  • Turid Heiberg
Detailed list of participants