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Therapeutic drug monitoring

The aim of medical treatment is to achieve optimal drug response and avoid harmful side effects for the individual patient. Clinical Pharmacology is the study of pharmacokinetic processes that is absorption, distribution, metabolism and excretion and response of drugs in the human body.

Individual variability in both the kinetics and effects of the drug is common. The effects/side effects of many drugs are concentration-dependent, hence it may be useful to measure the total drug concentration in serum/plasma, called therapeutic drug monitoring (TDM). Gene variants encoding proteins participating in metabolism, transport and drug actions may explain some of the concentration/response variability. 

Our research groups are working on the optimization of drug therapy using TDM, pharmacogenetic analyses and other outcome measures.


  • Measurements of methadone and corrected QT-time before and after conversion from racemic-methadone to R-methadone (Ullevål)
  • Measurements of serum concentrations of antihypertensive drugs (Ullevål)
  • Use of alcohol and psychoactive drugs in relation to somatic disease (Ullevål)
  • TDM of antiepileptic drugs-for various patient groups, studying pharmacokinetic variability, effects and side effects to ensure optimal and safe drug treatment (SSE)
Published Oct. 12, 2017 10:49 AM - Last modified Apr. 29, 2021 9:21 AM


Group leader


  • Mimi Stokke Opdal
  • Peter Krajci senior
  • Lill Dannevig Müller
  • Stine Rognstad
  • Ingebjørg Gusavsen
  • Cecilie Landmark Johannessen
  • Svein Ivar Johannessen
  • Margrete Larsen Burns
  • André Gottås
Detailed list of participants