Guest lecture: John Trowsdale
Genetic and functional interactions between MHC and NK receptors
We work on two gene complexes that encode sets of cell surface molecules key to coordination of responses to infection in humans: the Major Histocompatibility Complex (MHC) on chromosome 6p21.3 and the Leukocyte Receptor Complex (LRC) on chromosome 19q13.4. These clusters of genes exhibit features that reflect their roles: they are highly polymorphic and are associated with many diseases. There are genetic and functional associations between products within the MHC, such as class I, TAP transporters, proteasome components and Tapasin. There is also evidence of interaction between products of the two complexes, in particular between MHC class I molecules with KIR and LILR receptors. Since all of these molecules are highly polymorphic, combinations of alleles of ligand and receptor, inherited on different chromosomes, influence susceptibility to disease. We are examining the basis of the extreme variation in the MHC and LRC, interactions between their products and genetic association with disease.
About the speaker
Professor John Trowsdale, Cambridge Institute for Medical Research, University of Cambridge, UK, works on genetic and functional relationships between immune receptors with focus on the Major Histocompatibility Complex (MHC).
Fruit, cake and coffee will be served from 3 pm.
Centre for Immune Regulation