Guest lectures by Richard B. Mailman and Viacheslav Nikolaev
Welcome to two open lectures in pharmacology.
“Pharmacotherapy for Parkinson’s disease and the unexpected journey to novel mechanisms”
|Although hypothesis testing is the foundation of rigorous science, the most interesting directions often come from the unexpected. In seeking to improve the pharmacotherapy of Parkinson’s disease via testing a well-formulated hypothesis, two totally unexpected directions emerged. The first of these, functional selectivity/biased signaling, is now established as a major research front. The second, yet unpublished, is a novel phenomenon of receptor signaling in vivo with profound functional consequences.|
"Cardiomyocyte cAMP microdomains in health and disease”
|cAMP is an ubiquitous second messenger which regulates cardiac function and disease by acting in discrete subcellular microdomains. Until recently, it was not possible to visualize cAMP directly in these locales. Rapid development of new targeted biosensors and FRET imaging allowed exciting new insights into previously unknown local second messenger dynamics and new disease mechanisms.|