Aleksander Rygh Holten

• Barratt-Due, Andreas; Olsen, Inge Christoffer; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Lund-Johansen, Fridtjof; Hoel, Hedda Benedicte; Holten, Aleksander Rygh; Tveita, Anders; Mathiessen, Alexander; Haugli, Mette; Eiken, Ragnhild; Kildal, Anders Benjamin; Berg, Åse; Johannessen, Asgeir; Heggelund, Lars; Dahl, Tuva Børresdatter; Skåra, Karoline Hansen; Mielnik, Pawel; Le, Lan Ai Kieu; Thoresen, Lars; Ernst, Gernot; Hoff, Dag Arne Lihaug; Skudal, Hilde Kristin; Kittang, Bård Reiakvam; Olsen, Roy Bjørkholt; Tholin, Birgitte; Ystrøm, Carl Magnus; Skei, Nina Vibeche; Tran, Trung; Dudman, Susanne Gjeruldsen; Andersen, Jan Terje; Hannula, Raisa; Dalgard, Olav; Finbråten, Ane-Kristine; Tonby, Kristian; Blomberg, Bjorn; Aballi, Saad; Fladeby, Cathrine; Steffensen, Anne; Müller, Fredrik; Dyrhol-Riise, Anne Ma; Trøseid, Marius & Aukrust, Pål (2021). Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Annals of Internal Medicine.  ISSN 0003-4819. . doi: 10.7326/M21-0653 Vis sammendrag

  Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known. Objective: To evaluate the effects of remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx. Design: NOR-Solidarity is an independent, add-on, randomized controlled trial to the WHO Solidarity trial that included biobanking and 3 months of clinical follow-up (ClinicalTrials.gov: NCT04321616). Setting: 23 hospitals in Norway. Patients: Eligible patients were adults hospitalized with confirmed SARS-CoV-2 infection. Intervention: Between 28 March and 4 October 2020, a total of 185 patients were randomly assigned and 181 were included in the full analysis set. Patients received remdesivir (n = 42), HCQ (n = 52), or standard of care (SoC) (n = 87). Measurements: In addition to the primary end point of WHO Solidarity, study-specific outcomes were viral clearance in oropharyngeal specimens, the degree of respiratory failure, and inflammatory variables. Results: No significant differences were seen between treatment groups in mortality during hospitalization. There was a marked decrease in SARS-CoV-2 load in the oropharynx during the first week overall, with similar decreases and 10-day viral loads among the remdesivir, HCQ, and SoC groups. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammatory variables in plasma or serum. The lack of antiviral effect was not associated with symptom duration, level of viral load, degree of inflammation, or presence of antibodies against SARS-CoV-2 at hospital admittance. Limitation: The trial had no placebo group. Conclusion: Neither remdesivir nor HCQ affected viral clearance in hospitalized patients with COVID-19.

• Carr, Ewan; Bendayan, Rebecca; Bean, Daniel; Stammers, Matt; Wang, Wenjuan; Zhang, Huayu; Searle, Thomas; Kraljevic, Zeljko; Shek, Anthony; Phan, Hang T. T.; Muruet, Walter; Gupta, Rishi K.; Shinton, Anthony J.; Wyatt, Mike; Shi, Ting; Zhang, Xin; Pickles, Andrew; Stahl, Daniel; Zakeri, Rosita; Noursadeghi, Mahdad; O’Gallagher, Kevin; Rogers, Matt; Folarin, Amos; Karwath, Andreas; Wickstrøm, Kristin E.; Köhn-Luque, Alvaro; Slater, Luke; Cardoso, Victor Roth; Bourdeaux, Christopher; Holten, Aleksander Rygh; Ball, Simon; McWilliams, Chris; Roguski, Lukasz; Borca, Florina; Batchelor, James; Amundsen, Erik Koldberg; Wu, Xiaodong; Gkoutos, Georgios V.; Sun, Jiaxing; Pinto, Ashwin; Guthrie, Bruce; Breen, Cormac; Douiri, Abdel; Wu, Honghan; Curcin, Vasa; Teo, James T.; Shah, Ajay M. & Dobson, Richard (2021). Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study. BMC Medicine.  ISSN 1741-7015.  19:23, s 1- 16 . doi: 10.1186/s12916-020-01893-3 Fulltekst i vitenarkiv.
• Christensen, Erik; Jørgensen, Marthe Jøntvedt; Nore, Kristin Grotle; Dahl, Tuva Børresdatter; Yang, Kuan; Ranheim, Trine; Huse, Camilla; Lind, Andreas; Nur, Sarah; Stiksrud, Birgitte; Jenum, Synne; Tonby, Kristian; Holter, Jan Cato; Holten, Aleksander Rygh; Halvorsen, Bente & Dyrhol-Riise, Anne Ma (2021). Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns. Journal of Internal Medicine.  ISSN 0954-6820.  s 1- 16 . doi: 10.1111/joim.13310 Fulltekst i vitenarkiv.
• Gundem, Trine; Olasveengen, Theresa M.; Hovda, Knut Erik; Gaustad, Knut; Schøndorf, Christina Luise; Rostrup, Morten; Frøyshov, Sten; Undseth, Øystein; Tonby, Kristian; Holten, Aleksander Rygh & Sunde, Kjetil (2020). Ventilasjonsstotte for hypoksemiske intensivpasienter med covid-19. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  140(11), s 1- 10 . doi: 10.4045/tidsskr.20.0445 Fulltekst i vitenarkiv.
• Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne; Holten, Aleksander Rygh; Tonby, Kristian; Barratt-Due, Andreas; Sokolova, Marina; Schjalm, Camilla; Chaban, Viktoriia; Kolderup, Heidi Anette; Tran, Trung; Tollefsrud Gjølberg, Torleif; Skeie, Linda Gail; Hesstvedt, Liv; Ormaasen, Vidar; Fevang, Børre; Austad, Cathrine; Muller, Karl Erik; Fladeby, Cathrine; Holberg-Petersen, Mona; Halvorsen, Bente; Müller, Fredrik; Aukrust, Pål; Dudman, Susanne Gjeruldsen; Ueland, Thor; Andersen, Jan Terje; Lund-Johansen, Fridtjof; Heggelund, Lars; Dyrhol-Riise, Anne Ma & Mollnes, Tom Eirik (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  117(40), s 25018- 25025 . doi: 10.1073/pnas.2010540117 Fulltekst i vitenarkiv.
• Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian; Pischke, Soeren; Jenum, Synne; Skeie, Linda Gail; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne Gjeruldsen; Müller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh & Dyrhol-Riise, Anne Ma (2020). Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports.  ISSN 2045-2322.  10 . doi: 10.1038/s41598-020-78710-7 Fulltekst i vitenarkiv.
• Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian; Michelsen, Annika; Jenum, Synne; Jørgensen, Marthe Jøntvedt; Barratt-Due, Andreas; Skeie, Linda Gail; Nordøy, Ingvild; Fraz, Mai Sasaki Aanensen; Paulsen, Else Quist; Pischke, Soeren; Johal, Simreen Kaur; Hesstvedt, Liv; Bogen, Mette; Fevang, Børre; Halvorsen, Bente; Müller, Fredrik; Bekken, Gry Kloumann; Mollnes, Tom Eirik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma & Holter, Jan Cato (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  147(1), s 92- 98 . doi: 10.1016/j.jaci.2020.09.007 Fulltekst i vitenarkiv.
• Trydal, Elisabet; Martinsen, Anders B.; Beisland, Frode; Jacobsen, Dag & Holten, Aleksander Rygh (2019). Strukturert mottak av sepsispasienter og oppstart av antibiotika. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  139(9), s 811- 816 . doi: 10.4045/tidsskr.18.0216 Vis sammendrag

  BAKGRUNN Akuttmottaket ved Oslo universitetssykehus, Ullevål, innførte i 2017 en egen prosedyre for mottak av pasienter med mistenkt sepsis. Et strukturert sepsismottak skulle utløses hos disse pasientene, spesielt hvis minst to av tre kriterier i skåringsverktøyet Quick Sequential Organ Failure Assessment (qSOFA) var oppfylt. Vi ønsket å undersøke om tiltaket var hensiktsmessig for å oppfylle nasjonale anbefalinger om oppstart av antibiotika innen én time ved behandling av sepsis. MATERIALE OG METODE Voksne pasienter med mistenkt sepsis som ble tatt imot i strukturerte teammottak i perioden 15.5.–15.11.2017 ble inkludert. Det ble gjort en retrospektiv vurdering av om de inkluderte faktisk hadde hatt sepsis eller ikke. RESULTATER Det ble gitt antibiotika mot mistenkt sepsis i 216 strukturerte pasientmottak (172 sepsismottak og 44 medisinske teammottak). 175 (81 %) av pasientene fikk antibiotika innen den første timen i akuttmottaket. Mediantid fra ankomst til antibiotika ble igangsatt var 35 minutter. Bruk av qSOFA-skår alene fanget opp 80 (71 %) av de 112 pasientene som i ettertid ble klassifisert til å ha sepsis. FORTOLKNING Etter innføring av strukturert mottak av pasienter med mistenkt sepsis ble antibiotikabehandling i stor grad gitt innen én time.

• Holten, Aleksander Talgøy; Danbolt, Niels Christian; Keiko, S & Gundersen, Vidar (2008). Low-affinity excitatory amino acid uptake in hippocampal astrocytes: A possible role of Na+/dicarboxylate cotransporters. Glia.  ISSN 0894-1491.  56, s 990- 997 . doi: 10.1002/glia.20672
• Holten, Aleksander Talgøy & Gundersen, Vidar (2008). Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase. Journal of Neurochemistry.  ISSN 0022-3042.  104 . doi: 10.1111/j.1471-4159.2007.05065.x
• Holten, Aleksander Talgøy; Morland, Cecilie; Nordengen, Kaja & Gundersen, Vidar (2008). Vesicular Release of L- and D-Aspartate from Hippocampal Nerve Terminals: Immunogold Evidence. Open Neuroscience Journal.  ISSN 1874-0820.  2, s 51- 58 . doi: 10.2174/1874082000802010051
• Gundersen, Vidar; Holten, Aleksander Talgøy & Storm-Mathisen, Jon (2004). GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  26(1), s 156- 165

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• Ueland, Thor; Dyrhol-Riise, Anne Ma; Woll, Bjørn Martin; Holten, Aleksander Rygh; Pettersen, Frank O.; Lind, Andreas; Dudman, Susanne Gjeruldsen; Heggelund, Lars; Holter, Jan Cato & Aukrust, Pål (2021). Increased inflammatory markers reflecting fibrogenesis are independently associated with cardiac involvement in hospitalized COVID-19 patients. Journal of Infection.  ISSN 0163-4453.  82(5), s 186- 230 . doi: 10.1016/j.jinf.2021.01.017
• Gundem, Trine; Olasveengen, Theresa M.; Schøndorf, Christina Luise; Hovda, Knut Erik; Rostrup, Morten; Frøyshov, Sten; Undseth, Øystein; Tonby, Kristian; Holten, Aleksander Rygh; Sunde, Kjetil & Gaustad, Knut (2020). T.M. Gundem og medarbeidere svarer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  140(12), s 1- 2 . doi: 10.4045/tidsskr.20.0650 Fulltekst i vitenarkiv.
• Kolberg, Espen Skarstein; Wickstrøm, Kristin; Tonby, Kristian; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh & Amundsen, Erik Koldberg (2020). Serum ACE as a prognostic biomarker in COVID-19: A Case series. APMIS - Journal of Pathologiy, Microbiology and Immunology.  ISSN 0903-4641.  s 1- 2 . doi: 10.1111/apm.13108 Fulltekst i vitenarkiv.
• Ueland, Thor; Holter, Jan Cato; Holten, Aleksander Rygh; Muller, Karl Erik; Lind, A.; Bekken, Gry Klouman; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma & Heggelund, Lars (2020). Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure: MMP-9 and respiratory failure in COVID-19. Journal of Infection.  ISSN 0163-4453.  81(3), s e41- e43 . doi: 10.1016/j.jinf.2020.06.061
• Holten, Aleksander Talgøy (2013). Dobbel pylorus. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(6), s 645- 645 . doi: 10.4045/tidsskr.13.0033

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