Asbjørn Otto Christophersen

Bilde av Asbjørn Otto Christophersen
English version of this page
Rom A3.2026
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postadresse Pb 4950 Nydalen,OUS/RH 0424 Oslo

Bakgrunn

Utdannelse

  • 2015: PhD, Avdeling for Immunologi og Transfusjonsmedisin, Universitet i Oslo
  • 2008: MD, Eberhad Karls Universität Tübingen, Tyskland

Arbeidserfaring

  • Fra 2020: Lege i spesialisering, Revmatologisk avdeling, Oslo Universitetssykehus - Rikshospitalet
  • Fra 2016: Postdoktor, Avdeling for Immunologi og Transfusjonsmedisin og K. G. Jebsen-senter for cøliakiforskning, Universitetet i Oslo
  • 2016-2017: Postdoktor, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, USA (Mark M. Davis lab)
  • 2010-2015: PhD-kandidat, Avdeling for Immunologi og Transfusjonsmedisin, Universitet i Oslo
  • 2008-2010: Turnustjeneste for leger

Priser og Stipender

Publikasjoner

  • Christophersen, Asbjørn Otto; Dahal-Koirala, Shiva; Chlubnova, Marketa; Jahnsen, Jørgen; Lundin, Knut & Sollid, Ludvig Magne (2022). Phenotype-Based Isolation of Antigen-Specific CD4<sup>+</sup> T Cells in Autoimmunity: A Study of Celiac Disease. Advanced Science. ISSN 2198-3844. 9(10). doi: 10.1002/advs.202104766.
  • Christophersen, Asbjørn Otto; Zühlke, Stephanie; Lund, Eivind Gard; Snir, Omri; Dahal-Koirala, Shiva & Risnes, Louise Fremgaard [Vis alle 9 forfattere av denne artikkelen] (2021). Pathogenic T cells in celiac disease change phenotype on gluten challenge: Implications for T-cell-directed therapies. Advanced Science. ISSN 2198-3844. 8(21), s. 1–11. doi: 10.1002/advs.202102778.
  • Risnes, Louise Fremgaard; Eggesbø, Linn Margrethe; Zühlke, Stephanie; Dahal-Koirala, Shiva; Neumann, Ralf Stefan & Lundin, Knut Erik Aslaksen [Vis alle 8 forfattere av denne artikkelen] (2021). Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal Immunology. ISSN 1933-0219. 14(4), s. 842–851. doi: 10.1038/s41385-021-00385-8. Fulltekst i vitenarkiv
  • Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut E. A. & Sandve, Geir Kjetil [Vis alle 8 forfattere av denne artikkelen] (2021). Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs. Frontiers in Immunology. ISSN 1664-3224. 12:639672, s. 1–13. doi: 10.3389/fimmu.2021.639672. Fulltekst i vitenarkiv
  • Christophersen, Asbjørn (2019). Peptide-MHC class I and class II tetramers: From flow to mass cytometry. HLA. ISSN 2059-2302. s. 169–178. doi: 10.1111/tan.13789. Fulltekst i vitenarkiv
  • Eggesbø, Linn Margrethe; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Lundin, Knut Erik Aslaksen; Christophersen, Asbjørn & Sollid, Ludvig Magne (2019). Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease. Mucosal Immunology. ISSN 1933-0219. s. 1–9. doi: 10.1038/s41385-019-0222-9. Fulltekst i vitenarkiv
  • Zühlke, Stephanie; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Christophersen, Asbjørn; Sollid, Ludvig Magne & Lundin, Knut Erik Aslaksen (2019). CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease . United European Gastroenterology journal. ISSN 2050-6406. 7(10), s. 1337–1344. doi: 10.1177/2050640619874183.
  • Christophersen, Asbjørn; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva & Sollid, Ludvig Magne (2019). Therapeutic and diagnostic implications of T cell scarring in celiac disease and beyond. Trends in Molecular Medicine. ISSN 1471-4914. 25(10), s. 836–852. doi: 10.1016/j.molmed.2019.05.009. Fulltekst i vitenarkiv
  • Christophersen, Asbjørn; Lund, Eivind Gard; Snir, Omri; Solà, Elsa; Kanduri, Srinivasa Kalyana Chakravarthi & Dahal-Koirala, Shiva [Vis alle 15 forfattere av denne artikkelen] (2019). Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions. Nature Medicine. ISSN 1078-8956. 25(5), s. 734–737. doi: 10.1038/s41591-019-0403-9. Fulltekst i vitenarkiv
  • Dahal-Koirala, Shiva; Ciacchi, Laura; Petersen, Jan; Risnes, Louise Fremgaard; Neumann, Ralf Stefan & Christophersen, Asbjørn [Vis alle 11 forfattere av denne artikkelen] (2018). Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes . Journal of Biological Chemistry. ISSN 0021-9258. 294(3), s. 941–952. doi: 10.1074/jbc.RA118.005736. Fulltekst i vitenarkiv
  • Risnes, Louise Fremgaard; Christophersen, Asbjørn; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Sandve, Geir Kjetil & Sarna, Vikas Kumar [Vis alle 9 forfattere av denne artikkelen] (2018). Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. Journal of Clinical Investigation. ISSN 0021-9738. 128(6), s. 2642–2650. doi: 10.1172/JCI98819. Fulltekst i vitenarkiv
  • Tutturen, Astrid Elisabeth Voorham; Dørum, Siri; Clancy, Trevor; Reims, Henrik Mikael; Christophersen, Asbjørn & Lundin, Knut Erik Aslaksen [Vis alle 9 forfattere av denne artikkelen] (2018). Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry. American Journal of Pathology. ISSN 0002-9440. 188(7), s. 1563–1579. doi: 10.1016/j.ajpath.2018.03.017. Fulltekst i vitenarkiv
  • Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Mørkrid, Lars; Qiao, Shuo Wang; Sollid, Ludvig Magne & Christophersen, Asbjørn (2017). HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology. ISSN 0016-5085. 154(4), s. 886–896.e6. doi: 10.1053/j.gastro.2017.11.006. Fulltekst i vitenarkiv
  • Christophersen, Asbjørn (2016). Ny blodprøve kan forenkle diagnostikk av cøliaki. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(6), s. 555–555. doi: 10.4045/tidsskr.16.0106.
  • Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Christophersen, Asbjørn; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen & Sollid, Ludvig Magne [Vis alle 7 forfattere av denne artikkelen] (2016). TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage. Mucosal Immunology. ISSN 1933-0219. 9(3), s. 587–596. doi: 10.1038/mi.2015.147. Fulltekst i vitenarkiv
  • Christophersen, Asbjørn; Risnes, Louise Fremgaard; Bergseng, Elin; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne & Qiao, Shuo Wang (2016). Healthy HLA-DQ2.5&lt;sup&gt;+&lt;/sup&gt; subjects lack regulatory and memory T cells specific for immunodominant gluten epitopes of celiac disease. Journal of Immunology. ISSN 0022-1767. 196(6), s. 2819–2826. doi: 10.4049/jimmunol.1501152.
  • Sollid, Ludvig Magne; Iversen, Rasmus; Steinsbø, Øyvind; Qiao, Shuo Wang; Bergseng, Elin & Dørum, Siri [Vis alle 14 forfattere av denne artikkelen] (2015). Small bowel, celiac disease and adaptive immunity. Digestive Diseases. ISSN 0257-2753. 33(2), s. 115–121. doi: 10.1159/000369512.
  • Christophersen, Asbjørn; Raki, Melinda; Bergseng, Elin; Lundin, Knut E A; Jahnsen, Jørgen & Sollid, Ludvig Magne [Vis alle 7 forfattere av denne artikkelen] (2014). Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge. United European Gastroenterology journal. ISSN 2050-6406. 2(4), s. 268–278. doi: 10.1177/2050640614540154.
  • Dørum, Siri; Bodd, Michael; Fallang, Lars-Egil; Bergseng, Elin; Christophersen, Asbjørn & Johansen, Marie Kongshaug [Vis alle 10 forfattere av denne artikkelen] (2014). HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes. Journal of Immunology. ISSN 0022-1767. 193(9), s. 4497–4506. doi: 10.4049/jimmunol.1301466.
  • Qiao, Shuo Wang; Christophersen, Asbjørn; Lundin, Knut E A & Sollid, Ludvig Magne (2014). Biased usage and preferred pairing of α-and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease. International Immunology. ISSN 0953-8178. 26(1), s. 13–19. doi: 10.1093/intimm/dxt037.

Se alle arbeider i Cristin

  • Risnes, Louise Fremgaard; Eggesbø, Linn Margrethe; Christophersen, Asbjørn Otto & Sollid, Ludvig Magne (2021). Response to: “Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease”. Mucosal Immunology. ISSN 1933-0219. 14(5), s. 1216–1217. doi: 10.1038/s41385-021-00422-6.
  • Eggesbø, Linn Margrethe; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Lundin, Knut E. A.; Christophersen, Asbjørn Otto & Sollid, Ludvig Magne (2021). Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8<sup>+</sup> αβ T lymphocytes in untreated celiac disease. European Journal of Immunology. ISSN 0014-2980. 51(6), s. 1542–1545. doi: 10.1002/eji.202048974.

Se alle arbeider i Cristin

Publisert 17. sep. 2014 08:41 - Sist endret 3. mars 2021 14:31