Caroline Sophie Verbeke

Professor II - Department of Pathology
Image of Caroline Sophie Verbeke
Mobile phone 40557836 +47-40557836
Room A3.M011
Username
Visiting address Sognsvannsveien 20 Rikshospitalet 0320 Oslo Tel: (0047) 23071498
Postal address Postboks 4950 Nydalen 0424 OSLO

Fields of interest

  • Pathology of pancreatobiliary disease
  • Tumour heterogeneity
  • Cancer-stroma interaction
  • Chemotherapy-induced changes
  • Endocrine neoplasia of the digestive system

Background

  • MD: University of Antwerp, Belgium
  • Dr med: University of Heidelberg, Germany
  • PhD (Habilitation, Priv Doz): University of Heidelberg, Germany

Teaching

  • Undergraduate medical students, UiO (module 4 & 8)
  • Gastro-intestinal and hepatopancreatobiliary pathology

Commissions of trust

  • Member of the European study group on cystic tumours of the pancreas
  • Member of the Norwegian Gastrointestinal Cancer Group-HPB (https://ngicg.no/organisasjon/ngicg_hpb/)

  • Member of the Research Committee of the Norwegian Pathology Society

  • Member of the Steering committee of the pancreatic biobank, Oslo University Hospital

  • Member of the UICC TNM expert panel for endocrine tumours, Geneva, Switzerland

  • Chair of the ICCR (International Collaboration on Cancer Reporting) Dataset Authoring Committee for pancreatic cancer (https://www.iccr-cancer.org)

  • Member of the International Consensus Workshop for Pancreatic Ductal Adenocarcinoma Taxonomy

  • Member of Pancreatic Cancer Europe - National Support Work Stream

  • Chairman of the patient advocacy group Pancreatic Cancer Network Norway (www.pknn.no)

Tags: Pathology, Pancreatic cancer, Pancreatitis, Pancreatic disease, Neoadjuvant treatment, Tumour heterogeneity

Publications

Campbell F & Verbeke CS. Pathology of the pancreas. A practical approach. Springer 2013 (ISBN 978-1-4471-2449-8)

  • Del Chiaro, Marco; Besselink, Marc G; Bruno, Marco J; Cahen, Djuna L; Gress, Thomas M; Van Hooft, Jeanin E.; Lerch, Markus M.; Mayerle, Julia; Scholten, Lianne; Hackert, Thilo H.; Zerbi, Alessandro; Cunningham, David; De Angelis, Claudio Gi; de-Madaria, Enrique; Hegyi, Peter; Rosendahl, Jonas; Friess, Helmut; Manfredi, Riccardo; Lévy, Philippe; Real, Francisco X.; Sauvanet, Alain; Hilal, Mohammed A; Marchegiani, Giovanni; Esposito, Irene; Ghaneh, Paula; Engelbrecht, Marc RW; Fockens, Paul; van Huijgevoort, Nadine CM; Wolfgang, Christopher L.; Bassi, Claudio; Gubergrits, Natalya B; Verbeke, Caroline Sophie; Klöppel, Günter; Scarpa, Aldo; Zamboni, Giuseppe; O'Broin-Lennon, Anne Marie; Sund, Malin; Kartalis, Nikolaos; Grenacher, Lars; Arnelo, Urban; Kopchak, Kostantin V; Oppong, Kofi W.; McKay, Colin; Hauge, Truls; Conlon, Kevin; Adham, Mustapha; Ceyhan, Güralp O; Salvia, Roberto; Dervenis, Christos; Allen, Peter; Paye, Francois; Bartsch, Detlef K.; Löhr, Matthias; Mutignani, Massimiliano; Laukkarinen, Johanna; Schulick, Richard; Valente, Roberto; Seufferlein, Thomas; Capurso, Gabriele; Siriwardena, Ajith; Neoptolemos, John P.; Pukitis, Aldis & Segersvärd, Ralf (2018). European evidence-based guidelines on pancreatic cystic neoplasms. The European Study Group on Cystic Tumours of the Pancreas. Gut.  ISSN 0017-5749.  67(5), s 789- 804 . doi: 10.1136/gutjnl-2018-316027
  • Del Chiaro, Marco; Rangelova, Elena; Halimi, Asif; Ateeb, Zeeshan; Scandavini, Chiara; Valente, Roberto; Segersvard, Ralf; Arnelo, Urban & Verbeke, Caroline Sophie (2018). Pancreatectomy with arterial resection is superior to palliation in patients with borderline resectable or locally advanced pancreatic cancer. HPB.  ISSN 1365-182X.  21(2), s 219- 225 . doi: 10.1016/j.hpb.2018.07.017
  • Hessmann, E; Patzak, MS; Klein, L; Chen, N; Kari, V; Ramu, I; Bapiro, TE; Frese, KK; Gopinathan, A; Richards, FM; Jodrell, DI; Verbeke, Caroline Sophie; Li, X; Heuchel, Rainer; Löhr, JM; Johnsen, SA; Gress, TM; Ellenrieder, V & Neesse, A (2018). Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. Gut.  ISSN 0017-5749.  67(3), s 497- 507 . doi: 10.1136/gutjnl-2016-311954
  • Hugenschmidt, Harald; Labori, Knut Jørgen; Brunborg, Cathrine; Verbeke, Caroline Sophie; Seeberg, Lars Thomas; Schirmer, Cecilie; Renolen, Anne; Borgen, Elin; Naume, Bjørn & Wiedswang, Gro (2018). Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma. Annals of Surgery.  ISSN 0003-4932. . doi: 10.1097/SLA.0000000000003035
  • Jabbar, Karolina; Sadik, Riadh; Verbeke, Caroline Sophie; Arike, Liisa & Hansson, Gunnar C. (2018). Highly accurate identification of cystic precursor lesions of pancreatic cancer through targeted mass spectrometry: a phase IIc diagnostic study. Journal of Clinical Oncology.  ISSN 0732-183X.  36(4), s 367- 375 . doi: 10.1200/JCO.2017.73.7288
  • Kamposioras, Konstantinos; Tsimplouli, Chrysiida; Verbeke, Caroline Sophie; Anthoney, Alan; Daoukopoulou, Argyro; Papandreou, Christos N; Sakellaridis, Nikolaos; Vassilopoulos, George; Potamianos, Spyros P; Liakouli, Vasiliki; Migneco, Gemma; Del Galdo, Francesco & Dimas, Konstantinos (2018). Silencing of caveolin-1 in fibroblasts as opposed to epithelial tumor cells results in increased tumor growth rate and chemoresistance in a human pancreatic cancer model. International Journal of Oncology.  ISSN 1019-6439.  54(2), s 537- 549 . doi: 10.3892/ijo.2018.4640
  • Löhr, J.-Matthias; Panic, N.; Vujasinovic, Miroslav & Verbeke, Caroline Sophie (2018). The ageing pancreas: a systematic review of the evidence and analysis of the consequences. Journal of Internal Medicine.  ISSN 0954-6820.  283(5), s 446- 460 . doi: 10.1111/joim.12745
  • Sahakyan, Mushegh; Haugvik, Sven-Petter; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Ignjatovic, Dejan; Buanes, Trond; Labori, Knut Jørgen; Verbeke, Caroline Sophie & Edwin, Bjørn (2018). Can standardized pathology examination increase the lymph node yield following laparoscopic distal pancreatectomy for ductal adenocarcinoma?. HPB.  ISSN 1365-182X.  20(2), s 175- 181 . doi: 10.1016/j.hpb.2017.08.038
  • Verbeke, Caroline Sophie (2018). A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.. JOURNAL OF IMMUNOTHERAPY.  ISSN 1053-8550. . doi: 10.1097/CJI.0000000000000164
  • Verbeke, Caroline Sophie; Häberle, Lena; Lenggenhager, Daniela & Esposito, Irene (2018). Pathology assessment of pancreatic cancer following neoadjuvant treatment: Time to move on. Pancreatology (Print).  ISSN 1424-3903.  18(5), s 467- 476 . doi: 10.1016/j.pan.2018.04.010
  • Vujasinovic, Miroslav; Valente, Roberto; Maier, Pia; von Beckerath, Victoria; Haas, Stephan L; Arnelo, Urban; Del Chiaro, Marco; Kartalis, Nikolaos; Pozzi-Mucelli, Raffaella Maria; Fernandez-Moro, Carlos; Verbeke, Caroline Sophie; Yu, Jingru; Ye, Weimin & Löhr, J.-Matthias (2018). Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden. Pancreatology (Print).  ISSN 1424-3903.  18(8), s 900- 904 . doi: 10.1016/j.pan.2018.09.003 Full text in Research Archive.
  • Del Chiaro, Marco & Verbeke, Caroline Sophie (2017). Intraductal papillary mucinous neoplasms of the pancreas: reporting clinically relevant features.. Histopathology.  ISSN 0309-0167.  70(6), s 850- 860 . doi: 10.1111/his.13131
  • Gjelberg, Hilde; Hoem, Dag; Verbeke, Caroline Sophie; Eide, Johan; Cooper, John & Molven, Anders (2017). Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse.. Clinical Case Reports.  ISSN 2050-0904.  5(6), s 761- 768 . doi: 10.1002/ccr3.927 Full text in Research Archive.
  • Kleive, Dyre; Berstad, Audun Elnæs; Sahakyan, Mushegh; Verbeke, Caroline Sophie; Naper, Christian; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz; Line, Pål Dag & Labori, Knut Jørgen (2017). Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery. Journal of Vascular Surgery: Venous and Lymphatic Disorders.  ISSN 2213-3348.  6(1), s 66- 74 . doi: 10.1016/j.jvsv.2017.09.003
  • Kleive, Dyre; Sahakyan, Mushegh; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz; Edwin, Bjørn; Fosby, Bjarte; Line, Pål Dag & Labori, Knut Jørgen (2017). Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy. British Journal of Surgery.  ISSN 0007-1323.  104(11), s 1558- 1567 . doi: 10.1002/bjs.10603
  • Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie & Dueland, Svein (2017). Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial. BMC Surgery.  ISSN 1471-2482.  17(1) . doi: 10.1186/s12893-017-0291-1 Full text in Research Archive.
  • Malgerud, Linea; Lindberg, Johan; Wirta, Valtteri; Gustavsson-Liljefors, Maria; Karimi, Masoud; Moro, Carlos Fernández; Stecker, Katrin; Picker, Alexander; Huelsewig, Carolin; Stein, Martin; Bohnert, Regina; Del Chiaro, Marco; Haas, Stephan L; Heuchel, Rainer; Permert, Johan; Maeurer, Markus J; Brock, Stephan; Verbeke, Caroline Sophie; Engstrand, Lars; Jackson, David B; Grönberg, Henrik & Löhr, Johannes-Matthias (2017). Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer.. Molecular Oncology.  ISSN 1574-7891.  11(10), s 1413- 1429 . doi: 10.1002/1878-0261.12108
  • Seleznik, Gitta; Reding, Theresia; Peter, Lukas; Gupta, Anurag; Steiner, Sabrina G; Sonda, Sabrina; Verbeke, Caroline Sophie; Dejardin, Emmanuel; Khatkov, Igor; Segerer, Stephan; Heikenwalder, Mathias & Graf, Rolf (2017). Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.. Gut.  ISSN 0017-5749.  67(9), s 1663- 1673 . doi: 10.1136/gutjnl-2016-313458
  • Strell, Carina; Norberg, Karin Jessica; Mezheyeuski, Artur; Schnittert, Jonas; Kuninty, Praneeth R.; Moro, Carlos Fernández; Paulsson, Janna; Schultz, Nicolai Aagaard; Calatayud, Dan; Löhr, Johannes Matthias; Frings, Oliver; Verbeke, Caroline Sophie; Heuchel, Rainer Lothar; Prakash, Jai; Johansen, Julia Sidenius & Östman, Arne (2017). Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC. British Journal of Cancer.  ISSN 0007-0920.  117(1), s 65- 77 . doi: 10.1038/bjc.2017.140
  • Verbeke, Caroline Sophie (2017). Operative Specimen Handling and Evaluation of Resection Margins, In Sun Whe Kim & Hiroki Yamaue (ed.),  Pancreatic Cancer. With Special Focus on Topical Issues and Surgical Techniques.  Springer Publishing Company.  ISBN 978-3-662-47180-7.  Part I. Pathology and Tumor Biology.  s 67 - 87
  • Verbeke, Caroline Sophie; Löhr, Matthias; Heuchel, Rainer Lothar & Kartalis, Nikolaos (2017). A preliminary report: Radical surgery and stem cell transplantation for the treatment of patients with pancreatic cancer.. JOURNAL OF IMMUNOTHERAPY.  ISSN 1053-8550. . doi: 10.1097/CJI.0000000000000164
  • Fernández Moro, Carlos; Fernandez-Woodbridge, Alejandro; D'souza,, Melroy Alistair; Zhang,, Qianni; Bozoky, Benedek; Kandaswamy, Senthil Vasan; Catalano, Piera; Heuchel, Rainer l.; Shtembari, Sonia; Del Chiaro, Marco; Danielsson, Olof; Björnstedt, Mikael; Löhr, J.-Matthias; Isaksson, Bengt; Verbeke, Caroline Sophie & Bozóky, Béla (2016). Immunohistochemical typing of adenocarcinoma of the pancreatobiliary system improves diagnosis and prognostic stratification. PLoS ONE.  ISSN 1932-6203.  11 . doi: 10.1371/journal.pone.0166067
  • Haugvik, Sven-Petter; Kaemmerer, Daniel; Gaujoux, Sebastien; Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape. Current Oncology Reports.  ISSN 1523-3790.  18(5) . doi: 10.1007/s11912-016-0518-9
  • Kleive, Dyre; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz; Line, Pål Dag & Labori, Knut Jørgen (2016). Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery. HPB.  ISSN 1365-182X.  18(7), s 615- 622 . doi: 10.1016/j.hpb.2016.05.010 Show summary
  • Li, Xuan; Nania, Salvatore; Fejzibegovic, Nino; Fernández Moro, Carlos; Klopp-Schulze, Lena; Verbeke, Caroline Sophie; Löhr, J.-Matthias & Heuchel, Rainer l. (2016). Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-b signaling.. Biochimica et Biophysica Acta - Molecular Basis of Disease.  ISSN 0925-4439.  1862, s 1839- 1846 . doi: 10.1016/j.bbadis.2016.06.017
  • Pozzi-Mucelli, Raffaella Maria; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen; Ånonsen, Kim Vidar; Verbeke, Caroline Sophie; Del Chiaro, Marco & Kartalis, Nikolaos (2016). Pancreatic MRI for the surveillance of cystic neoplasms: comparison of a short with a comprehensive imaging protocol. European Radiology.  ISSN 0938-7994.  27(1), s 41- 50 . doi: 10.1007/s00330-016-4377-4
  • Tjomsland, Vegard; Pomianowska, Ewa; Aasrum, Monica; Sandnes, Dagny Lise; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Profile of MMP and TIMP expression in human pancreatic stellate cells: regulation by IL-1? and TGF? and implications for migration of pancreatic cancer cells. Neoplasia.  ISSN 1522-8002.  18(7), s 447- 456 . doi: 10.1016/j.neo.2016.06.003
  • Verbeke, Caroline Sophie (2016). Expansion of tumor-reactive T cells from patients with pancreatic cancer.. JOURNAL OF IMMUNOTHERAPY.  ISSN 1053-8550.  30, s 81- 90
  • Verbeke, Caroline Sophie (2016). Morphological heterogeneity in ductal adenocarcinoma of the pancreas - Does it matter?. Pancreatology (Print).  ISSN 1424-3903.  16(3), s 295- 301 . doi: 10.1016/j.pan.2016.02.004
  • Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Dissection of Pancreatic Resection Specimens. Surgical Pathology Clinics.  ISSN 1875-9181.  9(4), s 523- 538 . doi: 10.1016/j.path.2016.05.001
  • Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2012). Resection margin involvement and tumour origin in pancreatic head cancer. British Journal of Surgery.  ISSN 0007-1323.  99(8), s 1036- 1049 . doi: 10.1002/bjs.8734
  • Verbeke, Caroline Sophie; Knapp, Johannes & Gladhaug, Ivar Prydz (2011). Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment. Histopathology.  ISSN 0309-0167.  59(6), s 1111- 1121 . doi: 10.1111/j.1365-2559.2011.04056.x

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  • Kartalis, Nikolaos; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen; Ånonsen, Kim Vidar; Verbeke, Caroline Sophie; Del Chiaro, Marco & Mucelli, Raffaella Maria Pozzi (2015). Pancreatic MRI for the follow-up of cystic neoplasms: Comparison of a short with a comprehensive imaging protocol.
  • Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2015). Information needs among patients and a surveillance strategy after surgery for pancreatic and periampullary cancer. HPB Surgery.  ISSN 0894-8569.  17(7), s 659 . doi: 10.1111/hpb.12411

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Published Nov. 18, 2014 2:44 PM - Last modified Mar. 17, 2019 6:06 PM