Cecilie Wium

• Christensen, Jacob J.; Narverud, Ingunn; Ruuth, Maija; Heier, Martin; Ulven, Stine Marie; Bogsrud, Martin Prøven; Kovanen, Petri T.; Halvorsen, Bente; Oda, Michael N.; Wium, Cecilie; Retterstøl, Kjetil & Holven, Kirsten Bjørklund (2020). Children with familial hypercholesterolemia display changes in LDL and HDL function: a cross-sectional study. medRxiv. . doi: 10.1101/2020.11.11.20214247 Vis sammendrag

  Background The functional status of lipoprotein particles contributes to atherogenesis. The tendency of plasma LDL particles to aggregate and the ability of HDL particles to induce and mediate reverse cholesterol transport associate with high and low risk for cardiovascular disease in adult patients, respectively. However, it is unknown whether children with familial hypercholesterolemia (FH) display lipoprotein function alterations. Hypothesis We hypothesized that FH children had disrupted lipoprotein function. Methods We analyzed LDL aggregation susceptibility and HDL-apoA-I exchange to apoA-I ratio (HAE/apoA-I ratio), and activity of four proteins that regulate lipoprotein metabolism (CETP, LCAT, PLTP and PON1) in plasma samples derived from children with FH (n = 47) and from healthy children (n = 56). Potential biological mechanisms behind any variation in lipoprotein functionalities were explored using an NMR-based metabolomics profiling approach. Results LDL aggregation was higher and HAE/apoA-I ratio was lower in FH children than in healthy children. LDL aggregation associated positively with LDL-C and negatively with triglycerides, and HAE/apoA-I ratio associated negatively with LDL-C. Generally, the metabolomic profile for LDL aggregation was a mirror image of that for HAE/apoA-I ratio. Conclusions FH children displayed increased atherogenicity of LDL and disrupted HDL function. These newly observed functional alterations in LDL and HDL may increase the risk for atherosclerotic cardiovascular disease in FH children.

• Hansen, Anne-Marte; Wium, Cecilie; Lee-Ødegård, Sindre; Tierney, Audrey C.; McCarthy, Danielle; Roche, Helen M.; Drevon, Christian A; Birkeland, Kåre I. & Gulseth, Hanne Løvdal (2020). Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  80(4), s 282- 290 . doi: 10.1080/00365513.2020.1730433 Fulltekst i vitenarkiv.
• Hovland, Anders; Narverud, Ingunn; Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Aagnes, Inger; Ueland, Thor; Mulder, Monique; Leijten, Frank; Langslet, Gisle; Wium, Cecilie; Svilaas, Arne B; Arnesen, Kjell Erik; van Lennep, Jeanine Roeters; Aukrust, Pål; Halvorsen, Bente; Retterstøl, Kjetil & Holven, Kirsten Bjørklund (2020). Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers. Journal of Clinical Lipidology.  ISSN 1933-2874.  s 1- 8 . doi: 10.1016/j.jacl.2020.12.006 Fulltekst i vitenarkiv.
• Bhopal, Anand; Wium, Cecilie; Reisæter, Anna Varberg; Bhala, Neeraj & Kumar, Bernadette. N (2019). Organdonasjon for migranter og etniske minoriteter. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  139(13) . doi: 10.4045/tidsskr.19.0406
• Bogsrud, Martin Prøven; Græsdal, Asgeir; Johansen, Dan; Langslet, Gisle; Hovland, Anders; Arnesen, Kjell Erik; Mundal, Liv; Retterstøl, Kjetil; Wium, Cecilie & Holven, Kirsten Bjørklund (2019). LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a)in a large cohort of predominantly genetically verified familial hypercholesterolemia. Journal of Clinical Lipidology.  ISSN 1933-2874.  13(2), s 279- 286 . doi: 10.1016/j.jacl.2019.01.010 Fulltekst i vitenarkiv.
• Birkeland, Kåre I.; Grill, Valdemar Erik Robert; Wium, Cecilie; McQueen, Matthew J.; López-Jaramillo, Patricio; Lee, Shun Fu & Gerstein, Hertzel C. (2018). The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and negative subjects: A post-hoc analysis of the ORIGIN trial. Diabetes, obesity and metabolism.  ISSN 1462-8902.  21(2), s 429- 433 . doi: 10.1111/dom.13528 Fulltekst i vitenarkiv.
• Bogsrud, Martin Prøven; Langslet, Gisle; Wium, Cecilie; Johansen, Dan; Svilaas, Arne B & Holven, Kirsten Bjørklund (2017). Treatment goal attainment in children with familial hypercholesterolemia: A cohort study of 302 children in Norway. Journal of Clinical Lipidology.  ISSN 1933-2874.  12(2), s 375- 382 . doi: 10.1016/j.jacl.2017.11.009
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia. Atherosclerosis.  ISSN 0021-9150.  256 . doi: 10.1016/j.atherosclerosis.2016.11.031
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Data on circulating leukocyte subpopulations and inflammatory proteins in children with familial hypercholesterolemia and healthy children. Data in Brief.  ISSN 2352-3409.  10, s 587- 592 . doi: 10.1016/j.dib.2016.12.042
• Gulseth, Hanne Løvdal; Wium, Cecilie; Angel, Kristin; Eriksen, Erik Fink & Birkeland, Kåre I. (2017). Effects of Vitamin D supplementation on insulin sensitivity and insulin secretion in subjectswith type 2 diabetes and Vitamin D deficiency: A randomized controlled trial. Diabetes Care.  ISSN 0149-5992.  40(7), s 872- 878 . doi: 10.2337/dc16-2302
• Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal; Wium, Cecilie; Lattanzio, Stefano; Formoso, Gloria; Di Fulvio, Patrizia; Otterdal, Kari; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Gregersen, Ida; Stavik, Benedicte; Bjerkeli, Vigdis; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Davi, Giovanni & Aukrust, Pål (2016). LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro. Diabetologia.  ISSN 0012-186X.  59, s 2134- 2144 . doi: 10.1007/s00125-016-4036-y Fulltekst i vitenarkiv.
• Wium, Cecilie; Eggesbø, Heidi Beate; Ueland, Thor; Michelsen, Annika; Torjesen, Peter A; Aukrust, Pål & Birkeland, Kåre I. (2014). Adipose tissue distribution in relation to insulin sensitivity and inflammation in Pakistani and Norwegian subjects with type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  74(8), s 700- 707 . doi: 10.3109/00365513.2014.953571
• Wium, Cecilie; AASHEIM, ERLEND T.; Ueland, Thor; Michelsen, Annika; Thorsby, Per Medbøe; Larsen, Ingegerd Frøyshov; Torjesen, Peter A; Aukrust, Pål & Birkeland, Kåre I. (2013). Differences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional study. BMC Endocrine Disorders.  ISSN 1472-6823.  13(49) . doi: 10.1186/1472-6823-13-49 Fulltekst i vitenarkiv.
• Wium, Cecilie; Gulseth, Hanne Løvdal; Eriksen, Erik Fink & Birkeland, Kåre I. (2013). Characteristics of Glucose Metabolism in Nordic and South Asian Subjects with Type 2 Diabetes. PLOS ONE.  ISSN 1932-6203.  8(12) . doi: 10.1371/journal.pone.0083983 Fulltekst i vitenarkiv.
• Haukeland, John Willy; Dahl, Tuva Børresdatter; Yndestad, Arne; Gladhaug, Ivar Prydz; Løberg, Else Marit; Haaland, Therese Kristina; Zbigniew, Konopski; Wium, Cecilie; AASHEIM, ERLEND T.; Johansen, Odd Erik; Aukrust, Pål; Halvorsen, Bente & Birkeland, Kåre I. (2012). Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. European Journal of Endocrinology.  ISSN 0804-4643.  166(3), s 503- 510 . doi: 10.1530/EJE-11-0864
• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Skog, Karina; Opdahl, Anders; Wium, Cecilie; Ekeberg, Øivind & Jacobsen, Dag (2008). Acute poisonings treated in hospitals in Oslo: A one-year prospective study (II): Clinical outcome. Clinical Toxicology.  ISSN 1556-3650.  46(1), s 42- 49 . doi: 10.1080/15563650701210048 Vis sammendrag

  Objectives. The changing pattern of acute poisoning may affect complications and outcome in these patients. An update study on acute poisonings was therefore performed and compared to similar data from 1980. Design. A prospective cross-sectional multi-center study of all adult patients ( 16 years) hospitalized in Oslo with a main diagnosis of acute poisoning, irrespective of intention, over a one-year period. Results. Of 947 admissions, 222 (23%) were comatose. Complications were observed in 173 (18%), slightly reduced from 1980 (22%). Ten (1.1%) died and six (0.6%) got permanent sequelae, of which seven and five were drug- or alcohol-related, respectively. Seventy-five percent received treatment besides observation; 39% received antidotes, increased from 21% in 1980, most frequently flumazenil (23%) and naloxone (14%). Conclusions. In-hospital mortality in poisoned patients remained low, few patients entailed complications, and most patients survived without permanent sequelae. Drug- and alcohol-abuse related poisonings were most severe

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• Langslet, Gisle; Bogsrud, Martin Prøven; Wium, Cecilie; Johansen, Dan; Svilaas, Arne & Holven, Kirsten Bjørklund (2018). Some children with a familial hypercholesterolemia mutation may exhibit persistent low LDL levels. Journal of Clinical Lipidology.  ISSN 1933-2874.  12(5), s 1327- 1328 . doi: 10.1016/j.jacl.2018.06.012
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten B. (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Wium, Cecilie (2015). Authors' response to letter: 'Proper assessment of leptin results with confounders'. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  75(5), s 440- 440 . doi: 10.3109/00365513.2015.1035749
• Gulseth, Hanne Løvdal; Wium, Cecilie; Eriksen, Erik Fink & Birkeland, Kåre I. (2013). Effects of vitamin D supplementation on insulin sensitivity and secretion in subjects with type 2 diabetes: a randomised controlled trial. Diabetologia.  ISSN 0012-186X.  56, s S346- S346

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