Daniël Roelfs

• Hindley, Guy; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; O'Connell, Kevin Sean & Icick, Romain [Vis alle 17 forfattere av denne artikkelen] (2022). Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation. American Journal of Psychiatry. ISSN 0002-953X. 179(11), s. 833–843. doi: 10.1176/appi.ajp.21101051.
• Voldsbekk, Irene; Bjørnerud, Atle; Groote, Inge Rasmus; Zak, Nathalia; Roelfs, Daniël & Maximov, Ivan [Vis alle 18 forfattere av denne artikkelen] (2022). Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-022-01909-x. Fulltekst i vitenarkiv
• van der Meer, Dennis; Kaufmann, Tobias; Shadrin, Alexey; Makowski, Carolina; Frei, Oleksandr & Roelfs, Daniel [Vis alle 17 forfattere av denne artikkelen] (2021). The genetic architecture of human cortical folding. Science Advances. ISSN 2375-2548. 7(51), s. 1–9. doi: 10.1126/sciadv.abj9446. Fulltekst i vitenarkiv
• Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Vis alle 24 forfattere av denne artikkelen] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), s. 1751–1760. doi: 10.1093/schbul/sbab049. Fulltekst i vitenarkiv
• Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas [Vis alle 8 forfattere av denne artikkelen] (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01313-x. Fulltekst i vitenarkiv Vis sammendrag

  Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Using independent component analysis, we decomposed self-report mental health questionnaires from 136,678 healthy individuals of the UK Biobank, excluding data from individuals with a diagnosed neurological or psychiatric disorder, into 13 distinct profiles relevant to mental health, capturing different symptoms as well as social and risk factors underlying reduced mental health. Utilizing genotypes from 117,611 of those individuals with White British ancestry, we performed GWAS for each mental health profile and assessed genetic correlations between these profiles, and between the profiles and common psychiatric disorders and cognitive traits. We found that mental health profiles were genetically correlated with a wide range of psychiatric disorders and cognitive traits, with strongest effects typically observed between a given mental health profile and a disorder for which the profile is common (e.g. depression symptoms and major depressive disorder, or psychosis and schizophrenia). Strikingly, although the profiles were phenotypically uncorrelated, many of them were genetically correlated with each other. This study provides evidence that statistically independent mental health profiles partly share genetic underpinnings and show genetic overlap with psychiatric disorders, suggesting that shared genetics across psychiatric disorders cannot be exclusively attributed to the known overlapping symptomatology between the disorders.

• Voldsbekk, Irene; Groote, Inge Rasmus; Zak, Nathalia; Roelfs, Daniël Thomas Heimen; Geier, Oliver & Due-Tønnessen, Paulina [Vis alle 14 forfattere av denne artikkelen] (2021). Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling. NeuroImage. ISSN 1053-8119. 226. doi: 10.1016/j.neuroimage.2020.117540. Fulltekst i vitenarkiv
• Sæther, Linn Sofie; Roelfs, Daniël Thomas Heimen; Moberget, Torgeir; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn & Jönsson, Erik Gunnar [Vis alle 7 forfattere av denne artikkelen] (2020). Exploring neurophysiological markers of visual perspective taking: Methodological considerations. International Journal of Psychophysiology. ISSN 0167-8760. doi: 10.1016/j.ijpsycho.2020.12.006. Fulltekst i vitenarkiv Vis sammendrag

  Rationale: For visual perspective taking (VPT) using the avatar task, examinations of neural processes using event related potentials (ERP) indicate a distinction between an early posterior perspective calculation process (P3) and a later frontal process (LFSW) managing perspective conflict. While it is unknown if these neural processes are affected in clinical populations, it is unclear if the avatar task can be applied to this group, due to the long duration and sensitivity to data loss. Thus, we performed a methodological study of the avatar task, testing the feasibility of a shortened experimental paradigm. Objective: To investigate whether previously reported behavioural and ERP effects in the avatar task can also be seen if analysing all trials (matching/non-matching) jointly, and whether they remain robust if only a subset of the data is analysed. Method: Healthy individuals (n = 20) completed the avatar task with ERP measurement. ERP components (P3, LFSW) and behavioural data were investigated by A) comparing use of only matching trials (n = 384) versus all trials (n = 768), and B) examining if reduced duration of assessment, by analysing only a subset of the data, impacts ERP findings. Results: We observed minimal differences when analysing data from only matching trial types compared to all trial types. Further, ERP amplitudes and latency findings were replicated when analysing only a subset of the data. Conclusions: The duration of the avatar task can be reduced to avoid long testing times, thus making it better suited for use in clinical populations.

• Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides & Beck, Dani [Vis alle 18 forfattere av denne artikkelen] (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117302. Fulltekst i vitenarkiv
• Voldsbekk, Irene; Maximov, Ivan; Zak, Nathalia; Roelfs, Daniël Thomas Heimen; Geier, Oliver & Due-Tønnessen, Paulina [Vis alle 10 forfattere av denne artikkelen] (2020). Evidence for wakefulness-related changes to extracellular space in human brain white matter from diffusion-weighted MRI. NeuroImage. ISSN 1053-8119. 212. doi: 10.1016/j.neuroimage.2020.116682. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Voldsbekk, Irene; Roelfs, Daniël Thomas Heimen; Bjørnerud, Atle; Groote, Inge Rasmus & Maximov, Ivan (2019). White matter microstructure changes as a function of time-of-day: a biomarker of accumulating sleep pressure?

Se alle arbeider i Cristin