Finn Olav Levy

Bilde av Finn Olav Levy
English version of this page
Telefon +47 22840237
Mobiltelefon +47 47271676
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 1057 Blindern 0316 Oslo

Faglige interesser

Forskning om hjertesvikt, hjertefarmakologi og cellulær signaloverføring

Undervisning

Undervisning i farmakologi for medisinstudenter fra 3. til 12. semester

Bakgrunn

  • Cand. med., Universitetet i Oslo 1987
  • Dr. med., Universitetet i Oslo 1989
  • Autorisasjon som lege 1990
  • Professor i farmakologi fra 2004 

Verv

  • Fagmiljøleder, Avdeling for farmakologi

Samarbeid

Utstrakt nasjonalt og internasjonalt forskningssamarbeid vedr. hjertesvikt, hjertefarmakologi og cellulær signaloverføring

Emneord: Serotonin, Hjertesvikt, Reseptor, G-protein, Farmakologi

Publikasjoner

  • Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C.; Moltzau, Lise Roman; Bjørnerem, Marianne; Paterson, David; Kim, Choel; Levy, Finn Olav & Andressen, Kjetil Wessel (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology.  ISSN 2399-3642.  2:394, s 1- 12 . doi: 10.1038/s42003-019-0641-x Fulltekst i vitenarkiv.
  • Cosson, Marie-Victoire; Hiis, Halvard Gautefall; Moltzau, Lise Roman; Levy, Finn Olav & Krobert, Kurt Allen (2019). Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ? <sub>1</sub> -adrenoceptor-mediated inotropic response. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  131, s 132- 145 . doi: 10.1016/j.yjmcc.2019.04.017
  • Melsom, Elin Maria Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk; Osnes, Jan-Bjørn; Skomedal, Tor; Nikolaev, Viacheslav; Levy, Finn Olav & Krobert, Kurt Allen (2019). Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLOS ONE.  ISSN 1932-6203.  14:e021810(6), s 1- 19 . doi: 10.1371/journal.pone.0218110 Fulltekst i vitenarkiv.
  • Ndongson, Bernadin Dongmo; Lang, Guang-Ping; Mece, Odeta; Hechaichi, Nadine; Lajqi, Trim; Hoyer, Dirk; Brodhun, Michael; Heller, Regine; Wetzker, Reinhard; Franz, Marcus; Levy, Finn Olav & Bauer, Reinhard (2019). Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Research in Cardiology.  ISSN 0300-8428.  114:26(3), s 1- 20 . doi: 10.1007/s00395-019-0734-1
  • Hiis, Halvard Gautefall; Cosson, Marie-Victoire; Dahl, Christen Peder; Fiane, Arnt E; Levy, Finn Olav; Andersen, Geir Øystein & Krobert, Kurt Allen (2018). Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  315(5), s H1137- H1147 . doi: 10.1152/ajpheart.00208.2018 Fulltekst i vitenarkiv.
  • Ulsund, Amanda Hembre; Dahl, Marie; Frimurer, Thomas; Manfra, Ornella; Schwartz, Thue W.; Levy, Finn Olav & Andressen, Kjetil Wessel (2018). Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase. The FASEB Journal.  ISSN 0892-6638.  33(3), s 3870- 3886 . doi: 10.1096/fj.201800805RR
  • Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav; Marton, Janos; Froeyen, Mathy; Olberg, Dag Erlend; Diederich, Marc & Bormans, Guy (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery.  ISSN 1570-1808.  14(7), s 787- 797 . doi: 10.2174/1570180813666161101152943 Vis sammendrag
  • Andressen, Kjetil Wessel; Ulsund, Andrea Hembre; Krobert, Kurt Allen; Lohse, Martin J.; Bünemann, Moritz & Levy, Finn Olav (2017). Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation. The FASEB Journal.  ISSN 0892-6638.  32(2), s 1059- 1069 . doi: 10.1096/fj.201700486R
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology.  ISSN 0014-2999.  812, s 174- 183 . doi: 10.1016/j.ejphar.2017.07.014
  • Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy, In Viacheslav Nikolaev & Manuela Zaccolo (ed.),  Microdomains in the Cardiovascular System..  Springer.  ISBN 978-3-319-54578-3.  Chapter.  s 245 - 271
  • Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Gauthier-Landry, louis; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; barbier, olivier & Tasken, Kristin Austlid (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. OncoTarget.  ISSN 1949-2553.  7(2), s 1878- 1894 . doi: 10.18632/oncotarget.6479 Fulltekst i vitenarkiv. Vis sammendrag
  • Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  471(1), s 219- 225 . doi: 10.1016/j.bbrc.2016.01.132
  • Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  477(1), s 14- 19 . doi: 10.1016/j.bbrc.2016.05.138
  • Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology.  ISSN 0969-8051.  43(8), s 478- 489 . doi: 10.1016/j.nucmedbio.2016.05.003
  • Villar, Inmaculada C; Bubb, Kristen J; Moyes, Amie J; Steiness, Eva; Gulbrandsen, Trygve; Levy, Finn Olav & Hobbs, Adrian J (2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. British Journal of Pharmacology.  ISSN 0007-1188.  173(23), s 3386- 3401 . doi: 10.1111/bph.13634
  • Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter; Levy, Finn Olav & Krobert, Kurt Allen (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology.  ISSN 0007-1188.  172(15), s 3846- 3860 . doi: 10.1111/bph.13169
  • Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Messina, Angela; Levy, Finn Olav & Guccione, Salvatore (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  9(MAY) . doi: 10.3389/fnbeh.2015.00092 Fulltekst i vitenarkiv.
  • Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W.; Levy, Finn Olav & Andressen, Kjetil Wessel (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience.  ISSN 1948-7193.  6(7), s 1206- 1218 . doi: 10.1021/cn500339p
  • Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård; Andressen, Kjetil Wessel; Dahl, Marie; Levy, Finn Olav; Sutcliffe, Julie L. & Haraldsen, Ira Hebold (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm.  ISSN 2040-2503.  6, s 708- 714 . doi: 10.1039/c4md00486h
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0115547 Fulltekst i vitenarkiv.
  • Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(1), s 5- 14 . doi: 10.1007/s00210-013-0940-6
  • Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(18), s 4598- 4602 . doi: 10.1016/j.bmcl.2014.06.083
  • Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav; Schuster, Jens; Dahl, Niklas; Bryja, Vítězslav & Schulte, Gunnar (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal.  ISSN 0892-6638.  28(5), s 2293- 2305 . doi: 10.1096/fj.13-246363
  • Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(12), s 1177- 1186 . doi: 10.1007/s00210-014-1036-7
  • Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine.  ISSN 1549-1277.  9:e0106608(9) . doi: 10.1371/journal.pone.0106608 Fulltekst i vitenarkiv.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind; Lothe, Gustav B; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565. . doi: 10.1124/jpet.114.214882
  • Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(5), s 407- 417 . doi: 10.1007/s00210-013-0953-1
  • Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(7), s 1846- 1850 . doi: 10.1016/j.bmcl.2014.02.002
  • Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology.  ISSN 0007-1188.  171(23), s 5169- 5181 . doi: 10.1111/bph.12647
  • Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(22), s 7134- 7145 . doi: 10.1016/j.bmc.2013.09.004
  • Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  64, s 629- 637 . doi: 10.1016/j.ejmech.2013.03.060
  • Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research.  ISSN 0014-4819.  230(4), s 555- 568 . doi: 10.1007/s00221-013-3694-y
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor; Moe, Ingvild Tronstad; Hagelin, Else Marie Valbjørn; Sagave, Julia Fritzi; Valen, Guro; Levy, Finn Olav; Osnes, Jan-Bjørn; Skomedal, Tor & Attramadal, Håvard (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology.  ISSN 0026-895X.  84(3), s 372- 383 . doi: 10.1124/mol.113.087312
  • Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  56, s 129- 138 . doi: 10.1016/j.yjmcc.2012.11.015
  • Levay, Magdolna; Krobert, Kurt Allen; Wittig, Karola; Voigt, Niels; Bermudez, Marcel; Wolber, Gerhard; Dobrev, Dobromir; Levy, Finn Olav & Wieland, Thomas (2013). NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565.  347(1), s 69- 79 . doi: 10.1124/jpet.113.207266
  • Molenaar, Peter; Christ, Torsten; Hussain, Rizwan; Engel, Andreas; Berk, Emanuel; Gillette, Katherine T.; Chen, Lu; Galindo-Tovar, Alejandro; Krobert, Kurt Allen; Ravens, Ursula; Levy, Finn Olav & Kaumann, Alberto Julio (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology.  ISSN 0007-1188.  169(3), s 528- 538 . doi: 10.1111/bph.12167
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina; Ørstavik, Øivind; Sjaastad, Ivar; Christensen, Geir Arve; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology.  ISSN 0007-1188.  170(2), s 366- 379 . doi: 10.1111/bph.12282
  • Bilbija, Dusan; Haugen, Fred; Sagave, Julia Fritzi; Baysa, Anton; Bastani, Nasser Ezzatkhah; Levy, Finn Olav; Sirsjø, Allan; Blomhoff, Rune & Valen, Guro (2012). Retinoic Acid Signalling Is Activated in the Postischemic Heart and May Influence Remodelling. PLOS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0044740
  • Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar & Levy, Finn Olav (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0045489 Fulltekst i vitenarkiv.
  • Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav; Vanhoenacker, Peter & Van Craenenbroeck, Kathleen (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal.  ISSN 1742-464X.  279(11), s 1994- 2003 . doi: 10.1111/j.1742-4658.2012.08581.x
  • Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes; Osnes, Jan-Bjørn; Skomedal, Tor; Sandnes, Dagny Lise; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology.  ISSN 0014-2999.  686(1-3), s 66- 73 . doi: 10.1016/j.ejphar.2012.04.022
  • Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology.  ISSN 0300-8428.  107(5) . doi: 10.1007/s00395-012-0295-z
  • von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil; Krobert, Kurt Allen; Levy, Finn Olav; Larsen, Terje; Smiseth, Otto A.; Aasum, Ellen & Attramadal, Håvard (2012). Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  303(1), s H66- H74 . doi: 10.1152/ajpheart.00724.2011
  • Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(1), s 54- 71 . doi: 10.1111/j.1476-5381.2010.00890.x
  • Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  384(6), s 543- 553 . doi: 10.1007/s00210-011-0670-6
  • Berrade, Luis; Aisa, Bárbara; Ramirez, María; Galiano, Silvia; Guccione, Salvatore; Moltzau, Lise Roman; Levy, Finn Olav; Nicoletti, Ferdinando; Battaglia, Giuseppe; Molinaro, Gemma; Aldana, Ignacio; Monge, Antonio & Perez-Silanes, Silvia (2011). Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action. Journal of Medicinal Chemistry.  ISSN 0022-2623.  54(8), s 3086- 3090 . doi: 10.1021/jm2000773
  • Brattelid, Trond & Levy, Finn Olav (2011). Quantification of GPCR mRNA Using Real-Time RT-PCR. Methods in molecular biology.  ISSN 1064-3745.  746(3), s 165- 193 . doi: 10.1007/978-1-61779-126-0_9
  • Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(4), s 908- 916 . doi: 10.1111/j.1476-5381.2010.01097.x
  • Brattelid, Trond; Winer, Lisbeth Hagen; Levy, Finn Olav; Liestøl, Knut; Sejersted, Ole M & Andersson, Kristin Brevik (2010). Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies. BMC Molecular Biology.  ISSN 1471-2199.  11 . doi: 10.1186/1471-2199-11-22
  • Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  18(24), s 8600- 8613 . doi: 10.1016/j.bmc.2010.10.011
  • Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR).  ISSN 0008-6363.  85(4), s 763- 772 . doi: 10.1093/cvr/cvp364
  • Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology.  ISSN 0007-1188.  156(4), s 575- 586 . doi: 10.1111/j.1476-5381.2009.00016.x
  • Hussain, Rizwan; Qvigstad, Erik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology.  ISSN 0007-1188.  156(4), s 575- 586 . doi: 10.1111/j.1750-3639.2009.00016.x Vis sammendrag
  • Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor; Olsen, IC; Sjaastad, Ivar; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure.  ISSN 1388-9842.  11(8), s 771- 778 . doi: 10.1093/eurjhf/hfp087
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Dahl, Christen Peder; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology.  ISSN 0007-1188.  155(7), s 1005- 1014 . doi: 10.1038/bjp.2008.339
  • Gellynck, E; Laenen, K; Andressen, Kjetil Wessel; Lintermans, B; De Martelaere, K; Matthys, A; Levy, Finn Olav; Haegeman, G; Vanhoenacker, P & Van Craenenbroeck, K (2008). Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain. Gene.  ISSN 0378-1119.  426(1-2), s 23- 31 . doi: 10.1016/j.gene.2008.08.011
  • Kloster, Martine Müller; Hafte, Tolesa Tilahun; Moltzau, Lise Roman; Hallan, Elin; Dahle, Maria Krutå; Skålhegg, Bjørn Steen; Gaudernack, Gustav; Levy, Finn Olav; Naderi, Soheil & Blomhoff, Heidi Kiil (2008). EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cellular Signalling.  ISSN 0898-6568.  20(6), s 1169- 1178 . doi: 10.1016/j.cellsig.2008.02.007
  • Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Ruud Larsen, Ann-Kristin; Levy, Finn Olav; Tasken, Kjetil; Skjønsberg, Ole Henning & Christensen, Geir Arve (2008). Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovascular Research (CVR).  ISSN 0008-6363.  80(1), s 47- 54 . doi: 10.1093/cvr/cvn180
  • Levy, Finn Olav; Qvigstad, Eirik; Krobert, Kurt Allen; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications. Neuropharmacology.  ISSN 0028-3908.  55(6), s 1066- 1071 . doi: 10.1016/j.neuropharm.2008.07.010
  • Ngai, Jacob; Iversen, Trond Methi; Andressen, Kjetil Wessel; Levy, Finn Olav; Torgersen, Knut Martin; Vang, Torkel; Wettschureck, N & Tasken, Kjetil (2008). The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway. European Journal of Immunology.  ISSN 0014-2980.  38(11), s 3208- 3218
  • Ramberg, Håkon; Eide, Turid; Krobert, Kurt Allen; Levy, Finn Olav; Dizeyi, N; Bjartell, AS; Abrahamsson, PA & Tasken, Kristin Austlid (2008). Hormonal regulation of beta(2)-adrenergic receptor level in prostate cancer. The Prostate.  ISSN 0270-4137.  68(10), s 1133- 1142 . doi: 10.1002/pros.20778
  • Riise, J; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Sandnes, Dagny Lise; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2008). Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovascular Research (CVR).  ISSN 0008-6363.  80(3), s 407- 415 . doi: 10.1093/cvr/cvn216
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Effects of treatment with a 5-HT4 receptor antagonist in heart failure. British Journal of Pharmacology.  ISSN 0007-1188.  150, s 143- 152 . doi: 10.1038/sj.bjp.0706966
  • Birkeland, Jon Arne; Swift, Fredrik; Tovsrud, Nils; Enger, Ulla Helene; Lunde, Per Kristian; Qvigstad, Eirik; Levy, Finn Olav; Sejersted, Ole M & Sjaastad, Ivar (2007). Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  293, s H2367- H2376 . doi: 10.1152/ajpheart.01375.2006
  • Brattelid, Trond; Qvigstad, E; Birkeland, Jan Magne; Birkeland, Jon Arne; Swift, F; Bekkevold, SVS; Krobert, KA; Sejersted, Ole M.; Skomedal, T; Osnes, JB; Levy, F. & Sjaastad, I (2007). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  43, s 767- 779 . doi: 10.1016/j.yjmcc.2007.08.019
  • Brattelid, Trond; Tveit, Kristine; Birkeland, Jon Arne; Sjaastad, Ivar; Qvigstad, Eirik; Krobert, Kurt Allen; Rizwan, Hussain; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure : A quantitative RT-PCR study and the question of normalisation. Basic Research in Cardiology.  ISSN 0300-8428.  102, s 198- 208 . doi: 10.1007/s00395-007-0648-1

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  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Ytrehus, Kirsti; Larsen, Terje; Christensen, Geir Arve; Stensløkken, Kåre-Olav & Levy, Finn Olav (2015). In memory of Guro Valen (1960-2014). Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  79, s 254- 255 . doi: 10.1016/j.yjmcc.2014.11.026
  • Dugstad, K.; Ulsund, Andrea Hembre; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela; Levy, Finn Olav & Andressen, Kjetil Wessel (2014). Unraveling tight spatial regulation of 5-HT4 receptor-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eric & Levy, Finn Olav (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
  • Levy, Finn Olav (2013). Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  386(8), s 665- 670 . doi: 10.1007/s00210-013-0874-z
  • Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR).  ISSN 0008-6363.  93, s S18- S18 . doi: 10.1093/cvr/cvr332
  • Andressen, Kjetil Wessel; Dugstad, KS; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2011). Unraveling tight spatiotemporal regulation of cAMP-mediated inotropic effects using targeted FRET-based cAMP sensors.
  • Meier, Silja; Aronsen, Jan Magnus; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Enhancement of B1-adrenoceptor signaling by C-type natriuretic peptide through natriuretic peptide receptor B in normal and failing hearts: regulation by phosphodiesterases.
  • Melsom, CB; Hussain, Rizwan; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of "tonic" Gi activation.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
  • Afzal, Faraz & Levy, Finn Olav (2010). Phosphodiesterases and regulation of contractile function through β-adrenoceptors and 5-HT4 receptors in the failing heart.
  • Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
  • Meier, Silja; Levy, Finn Olav; Skomedal, Tor; Qvigstad, Eirik & Osnes, Jan-Bjørn (2010). Cardiac tissue hypothyroidism and receptor functions in heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
  • Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
  • Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
  • Krobert, Kurt Allen; Hussain, Rizwan; Afzal, Faraz; Aronsen, Jon magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor & Levy, Finn Olav (2009). Inreased Gi activity does not contribute to the reduced beta-adrenergic inotropic effect in failing rat ventricle but Gi acts as a tonic brake on basal adenylyl cyclase activity.
  • Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Larsen, A; Levy, Finn Olav; Tasken, Kjetil; Skjønsberg, Ole Henning & Christensen, Geir Arve (2009). Increased circulating IL-18; a possible mechanism for hypoxia-induced cardiac dysfunction.
  • Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Levy, Finn Olav; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2009). Mechanisms for cardiac dysfunction in COPD and respiratory failure. Respiratory Medicine.  ISSN 0954-6111.  103, s S6- S7
  • Andressen, Kjetil Wessel & Levy, Finn Olav (2008). The 5-HT₇ serotonin receptor : G protein preassociation and functional selectivity. Dissertation for the degree of Dr.Med.. 601.
  • Eikemo, Hilde; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Evidence for an unidentified kinase activity phosphorylating myosin light chain-2 in quiescent cardiomyocytes. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  44, s 782- 782 . doi: 10.1016/j.yjmcc.2008.02.170
  • Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry.  ISSN 0003-2697.  383(2), s 323- 325 . doi: 10.1016/j.ab.2008.09.011
  • Kjekshus, John; Edvardsen, Thor; Gullestad, Lars; Koeber, L; Osnes, Jan-Bjørn; Qvigstad, Erik; Sjaastad, Ivar; Skomedal, Tor; Torp-Pedersen, C & Levy, Finn Olav (2008). The effect of Piboserod a 5-HT4-receptor antagonist on left ventricular function in patients with symptomatic heart failure.
  • Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Levy, Finn Olav; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2008). Mechanisms for cardiac dysfunction in COPD and respiratory failure.
  • Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2008). Alveolar hypoxia induces cardiac diastolic dysfunction: a role for a reduction in the calcium regulating protein phospholamban induced by IL-18.
  • Levy, Finn Olav (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricle. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 131- 131
  • Levy, Finn Olav (2008). Antagonist-mediated down-regulation of 5-HT7 receptors by the atypical antipsychotics clozapine and olanzapine: evidence for functional selectivity. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 60- 60
  • Levy, Finn Olav (2008). Regulation of the failing cardiac ventricle through 5-HT2A and 5-HT4 receptors: mechanisms and possible therapeutic consequences. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 17- 17
  • Levy, Finn Olav (2008). Role of myocardial 5-HT4 and 5-HT2A receptors in heart failure. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 112- 112
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 17- 17
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Aronsen, Jon magnus; Qvigstad, Eirik; Hougen, Karina; Birkeland, Jon Arne; Levy, Finn Olav; Osnes, Jan-Bjørn; Andersson, Kristin Brevik; Christensen, Geir Arve; Sejersted, Ole M; Skomedal, Tor & Sjaastad, Ivar (2007). Role of alpha-1-adrenergic signallling in Serca2 knockout mice.

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Publisert 13. apr. 2011 11:41 - Sist endret 26. okt. 2016 14:20