Harald Arnesen

• Arnesen, Harald; Myhre, Peder Langeland & Seljeflot, Ingebjørg (2020). Very long chain marine n-3 polyunsaturated fatty acids in atherothrombotic heart disease. A brief review, with a focus on metabolic effects. Nutrients.  ISSN 2072-6643.  12(10), s 1- 12 . doi: 10.3390/nu12103014 Fulltekst i vitenarkiv.
• Bratset, Vibeke; MARGEIRSDOTTIR, HANNA DIS; Chiva-Blanch, Gemma; Heier, Martin; Solheim, Svein; Arnesen, Harald; Dahl-Jørgensen, Knut & Seljeflot, Ingebjørg (2020). Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study. Journal of Diabetes Research.  ISSN 2314-6745.  2020, s 1- 8 . doi: 10.1155/2020/7216863 Fulltekst i vitenarkiv.
• Bratset, Vibeke; MARGEIRSDOTTIR, HANNA DIS; Heier, Martin; Solheim, Svein; Arnesen, Harald; Dahl-Jørgensen, Knut & Seljeflot, Ingebjørg (2020). Procoagulant activity in children and adolescents on intensive insulin therapy. Pediatric Diabetes.  ISSN 1399-543X.  21(3), s 496- 504 . doi: 10.1111/pedi.12978
• Hilde, Janne Mykland; Hisdal, Jonny; Skjørten, Ingunn; Hansteen, Viggo; Melsom, Morten Nissen; Grøtta, Ole Jørgen; Småstuen, Milada Cvancarova; Seljeflot, Ingebjørg; Arnesen, Harald; Humerfelt, Sjur & Steine, Kjetil (2020). Left ventricular dysfunction in COPD without pulmonary hypertension. PLOS ONE.  ISSN 1932-6203.  15(7) . doi: 10.1371/journal.pone.0235075
• Kluge, Karsten Engseth; Langseth, Miriam Sjåstad; Opstad, Trine Baur; Pettersen, Alf Åge Reistad; Arnesen, Harald; Tønnessen, Theis; Seljeflot, Ingebjørg & Helseth, Ragnhild (2020). Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease. Mediators of Inflammation.  ISSN 0962-9351.  2020 . doi: 10.1155/2020/5080743
• Awoyemi, Ayodeji Olawale; Trøseid, Marius; Arnesen, Harald; Solheim, Svein & Seljeflot, Ingebjørg (2019). Effects of dietary intervention and n-3 PUFA supplementation on markers of gut-related inflammation and their association with cardiovascular events in a high-risk population. Atherosclerosis.  ISSN 0021-9150.  286, s 53- 59 . doi: 10.1016/j.atherosclerosis.2019.05.004
• Bratset, Vibeke; Chiva-Blanch, Gemma; Byrkjeland, Rune; Solheim, Svein; Arnesen, Harald & Seljeflot, Ingebjørg (2019). Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training. Diabetes & vascular disease research.  ISSN 1479-1641.  16(5), s 431- 439 . doi: 10.1177/1479164119843094 Fulltekst i vitenarkiv.
• Chiva Blanch, Gemma; Laake, Kristian; Myhre, Peder Langeland; Bratset, Vibeke; Arnesen, Harald; Solheim, Svein; Badimon, Lina & Seljeflot, Ingebjørg (2019). High Adherence to the Nordic Diet Is Associated with Lower Levels of Total and Platelet-Derived Circulating Microvesicles in a Norwegian Population. Nutrients.  ISSN 2072-6643.  11(5), s 1- 12 . doi: 10.3390/nu11051114 Fulltekst i vitenarkiv.
• Cwikiel, Joanna; Seljeflot, Ingebjørg; Fagerland, Morten; Wachtell, Kristian; Arnesen, Harald; Berge, Eivind & Flaa, Arnljot (2019). High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease. International Journal of Cardiology.  ISSN 0167-5273.  287, s 1- 6 . doi: 10.1016/j.ijcard.2019.04.019 Fulltekst i vitenarkiv.
• Helseth, Ragnhild; Knudsen, Eva Cecilie; Eritsland, Jan; Opstad, Trine Baur; Arnesen, Harald; Andersen, Geir Øystein & Seljeflot, Ingebjørg (2019). Glucose associated NETosis in patients with ST-elevation myocardial infarction: An observational study. BMC Cardiovascular Disorders.  ISSN 1471-2261.  19:221, s 1- 8 . doi: 10.1186/s12872-019-1205-1 Fulltekst i vitenarkiv.
• Helseth, Ragnhild; Shetelig, Christian; Andersen, Geir Øystein; Langseth, Miriam Sjåstad; Limalanathan, Shanmuganathan; Opstad, Trine Baur; Arnesen, Harald; Hoffmann, Pavel; Eritsland, Jan & Seljeflot, Ingebjørg (2019). Neutrophil extracellular trap components associate with infarct size, ventricular function, and clinical outcome in STEMI. Mediators of Inflammation.  ISSN 0962-9351.  2019:784691, s 1- 10 . doi: 10.1155/2019/7816491 Fulltekst i vitenarkiv.
• Kalstad, Are; Tveit, Sjur Hansen; Myhre, Peder Langeland; Laake, Kristian; Opstad, Trine Baur; Tveit, Arnljot; Schmidt, Erik Berg; Solheim, Svein; Arnesen, Harald & Seljeflot, Ingebjørg (2019). Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients. BMC Geriatrics.  ISSN 1471-2318.  19:376, s 1- 9 . doi: 10.1186/s12877-019-1383-9 Fulltekst i vitenarkiv.
• Knudsen, Eva Cecilie; Seljeflot, Ingebjørg; Aksnes, Tonje Amb; Eritsland, Jan; Arnesen, Harald & Andersen, Geir Øystein (2019). IgM antibodies against phosphorylcholine measured early after acute ST-elevation myocardial infarction in relation to atherosclerotic disease burden and long-term clinical outcome. PLOS ONE.  ISSN 1932-6203.  14(4), s 1- 9 . doi: 10.1371/journal.pone.0215640 Fulltekst i vitenarkiv.
• Opstad, Trine Baur; Kalstad, Are Annesønn; Pettersen, Alf Åge Reistad; Arnesen, Harald & Seljeflot, Ingebjørg (2019). Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. Experimental Gerontology.  ISSN 0531-5565.  119, s 53- 60 . doi: 10.1016/j.exger.2019.01.020 Fulltekst i vitenarkiv.
• Warlo, Ellen Mathea Kirsch; Arnesen, Harald & Seljeflot, Ingebjørg (2019). A brief review on resistance to P2Y<sub>12</sub> receptor antagonism in coronary artery disease. Thrombosis Journal.  ISSN 1477-9560.  17(1) . doi: 10.1186/s12959-019-0197-5 Fulltekst i vitenarkiv.
• Zaidi, Hani; Byrkjeland, Rune; Unhammer Njerve, Ida; Åkra, Sissel; Solheim, Svein; Arnesen, Harald; Seljeflot, Ingebjørg & Opstad, Trine Baur (2019). Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial. Diabetes & vascular disease research.  ISSN 1479-1641. . doi: 10.1177/1479164119836922 Fulltekst i vitenarkiv.
• Zaidi, Hani; Byrkjeland, Rune; Unhammer Njerve, Ida; Åkra, Sissel; Solheim, Svein; Arnesen, Harald; Seljeflot, Ingebjørg & Opstad, Trine Baur (2019). Effects of exercise training on markers of adipose tissue remodeling in patients with coronary artery disease and type 2 diabetes mellitus: Sub study of the randomized controlled EXCADI trial. Diabetology and Metabolic Syndrome.  ISSN 1758-5996.  11:109, s 1- 9 . doi: 10.1186/s13098-019-0508-9 Fulltekst i vitenarkiv.
• Awoyemi, Ayodeji Olawale; Trøseid, Marius; Arnesen, Harald; Solheim, Svein & Seljeflot, Ingebjørg (2018). Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: A cross-sectional study. Diabetology and Metabolic Syndrome.  ISSN 1758-5996.  10(1) . doi: 10.1186/s13098-018-0360-3 Fulltekst i vitenarkiv.
• Cwikiel, Joanna; Seljeflot, Ingebjørg; Berge, Eivind; Unhammer Njerve, Ida; Ulsaker, Hilde; Arnesen, Harald & Flaa, Arnljot (2018). Effect of strenuous exercise on mediators of inflammation in patients with coronary artery disease. Cytokine.  ISSN 1043-4666.  105, s 17- 22 . doi: 10.1016/j.cyto.2018.02.006
• Hansen, Charlotte Holst; Ritschel, Vibeke Nordmo; Andersen, Geir Øystein; Halvorsen, Sigrun; Eritsland, Jan; Arnesen, Harald & Seljeflot, Ingebjørg (2018). Markers of thrombin generation are associated with long-term clinical outcome in patients With ST-segment elevation myocardial infarction. Clinical and applied thrombosis/hemostasis.  ISSN 1076-0296.  24(7), s 1088- 1094 . doi: 10.1177/1076029618764847 Fulltekst i vitenarkiv.
• Horjen, Anja Wiedswang; Ulimoen, Sara Reinvik; Norseth, Jon; Svendsen, Jesper Hastrup; Smith, Pål; Arnesen, Harald; Seljeflot, Ingebjørg & Tveit, Arnljot (2018). High-sensitivity troponine I in persistent atrial fibrillation - relation to NT-proBNP and markers of inflammation and haemostasis. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  78(5), s 386- 392 . doi: 10.1080/00365513.2018.1481224 Vis sammendrag

  Purpose: As cardiac troponins emerge as prognostic markers in atrial fibrillation (AF), it is important to identify mechanisms initiating and perpetuating cardiac troponin release, including its relations to other circulating biomarkers, in AF populations. We studied associations between high-sensitivity troponin I (hs-TnI) and markers representing myocardial wall tension, inflammation and haemostasis in persistent AF. Methods: In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion for persistent AF were randomised to receive candesartan or placebo for 3–6 weeks before and 6 months after cardioversion. Associations between baseline levels of hs-TnI and other biomarkers were investigated by bivariate non-parametric correlations (Spearman’s correlation coefficient denoted rs). Results: Baseline levels of hs-TnI correlated significantly, although weakly, with interleukin-6 (rs¼0.260, p¼.003), N-terminal pro-B-type natriuretic peptide (rs¼0.251, p¼.004), tissue-plasminogen activator antigen (rs¼0.233, p¼.008), D-dimer (rs¼0.220, p¼.013), E-selectin (rs¼0.207, p¼.019), high-sensitivity C-reactive protein (rs¼0.202, p¼.022) and vascular cell adhesion molecule-1 (rs¼0.189, p¼.032). Conclusions: Hs-TnI correlated weakly with biomarkers representing myocardial wall tension, inflammation and haemostasis in persistent AF. The lack of any strong correlation between hs-TnI and the investigated biomarkers is in concert with the idea that hs-TnI release is an independent process parallel to other pathophysiological mechanisms associated with AF. Abbreviations: AF: atrial fibrillation; CAPRAF study: CAndesartan in the Prevention of Relapsing Atrial Fibrillation study; CD40L: CD40 ligand; CHA2DS2-VASc score: a measure of stroke risk in patients with atrial fibrillation, with scores ranging from 0 to 9 and higher scores indicating greater risk; CV: coefficient of variation; hs-CRP: high-sensitivity C-reactive protein; ELISA: enzyme-linked immunosorbent assay; ETP: endogenous thrombin potential; hs-TnI: high-sensitivity troponin I; IL-6: interleukin-6; NTproBNP: N-terminal pro-B-type natriuretic peptide; F1þ2: prothrombin fragment 1þ2; TNF-a: tumour necrosis factor alpha; sTF: soluble tissue factor; t-PA antigen: tissue-plasminogen activator antigen; PAI- 1: plasminogen activator inhibitor type 1; VCAM-1: vascular cell adhesion molecule-1; vWF: von Willebrand factor; YKL-40: chitinase-3-like protein 1

• Langseth, Miriam Sjåstad; Opstad, Trine Baur; Bratset, Vibeke; Solheim, Svein; Arnesen, Harald; Pettersen, Alf Åge Reistad; Seljeflot, Ingebjørg & Helseth, Ragnhild (2018). Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  25(7), s 762- 769 . doi: 10.1177/2047487318760618
• Opstad, Trine Baur; Seljeflot, Ingebjørg; Bøhmer, Ellen; Arnesen, Harald & Halvorsen, Sigrun (2018). MMP-9 and its regulators TIMP-1 and EMMPRIN in patients with acute ST-elevation myocardial infarction: a NORDISTEMI substudy. Cardiology.  ISSN 0008-6312.  139(1), s 17- 24 . doi: 10.1159/000481684
• Abdelnoor, Michael; Andersen, Jack Gunnar; Arnesen, Harald & Johansen, Odd (2017). Early discharge compared with ordinary discharge after percutaneous coronary intervention - a systematic review and meta-analysis of safety and cost. Vascular Health and Risk Management.  ISSN 1176-6344.  13, s 101- 109 . doi: 10.2147/VHRM.S122951 Fulltekst i vitenarkiv.
• Bratseth, Vibeke; Byrkjeland, Rune; Unhammer Njerve, Ida; Solheim, Svein; Arnesen, Harald & Seljeflot, Ingebjørg (2017). Procoagulant activity in patients with combined type 2 diabetes and coronary artery disease: No effects of long-term exercise training. Diabetes & vascular disease research.  ISSN 1479-1641.  14(2), s 144- 151 . doi: 10.1177/1479164116679080 Fulltekst i vitenarkiv.
• Byrkjeland, Rune; Unhammer Njerve, Ida; Arnesen, Harald; Seljeflot, Ingebjørg & Solheim, Svein (2017). Reduced endothelial activation after exercise is associated with improved HbA1c in patients with type 2 diabetes and coronary artery disease. Diabetes & vascular disease research.  ISSN 1479-1641.  14(2), s 94- 103 . doi: 10.1177/1479164116679077 Fulltekst i vitenarkiv.
• Chiva Blanch, Gemma; Bratseth, Vibeke; Ritschel, Vibeke Nordmo; Andersen, Geir Øystein; Halvorsen, Sigrun; Eritsland, Jan; Arnesen, Harald; Badimon, Lina & Seljeflot, Ingebjørg (2017). Monocyte-derived circulating macroparticles (CD14+,CD14+/CD11b and CD14+/CD142+) as related to long-term prognosis for cardiovascular mortality in STEMI patient. International Journal of Cardiology.  ISSN 0167-5273.  227, s 876- 881 . doi: 10.1016/j.ijcard.2016.11.302 Fulltekst i vitenarkiv.
• Chiva Blanch, Gemma; Laake, Kristian; Myhre, Peder Langeland; Bratseth, Vibeke; Arnesen, Harald; Solheim, Svein; Badimon, Lina & Seljeflot, Ingebjørg (2017). Platelet-, monocyte-derived & tissue factorcarrying circulating microparticles are related to acute myocardial infarction severity. PLOS ONE.  ISSN 1932-6203.  12:e0172558(2), s 1- 12 . doi: 10.1371/journal.pone.0172558 Fulltekst i vitenarkiv.
• Cwikiel, Joanna; Seljeflot, Ingebjørg; Berge, Eivind; Arnesen, Harald; Wachtell, Kristian; Ulsaker, Hilde & Flaa, Arnljot (2017). Pro-coagulant activity during exercise testing in patients with coronary artery disease. Thrombosis Journal.  ISSN 1477-9560.  15:3, s 1- 7 . doi: 10.1186/s12959-016-0127-8 Fulltekst i vitenarkiv.
• Gharagozlian, Sedegheh; Hansen, Renate; Haugen, Margaretha; Johansen, Odd; Seierstad, Sverre Ludvig; Seljeflot, Ingebjørg & Arnesen, Harald (2017). Changes in dietary pattern when including 700 g of salmon per week to patients with atherosclerotic heart disease. Clinical Nutrition ESPEN.  ISSN 2405-4577.  19, s 38- 44 . doi: 10.1016/j.clnesp.2017.02.004
• Horjen, Anja Wiedswang; Seljeflot, Ingebjørg; Berge, Trygve; Smith, Pål; Arnesen, Harald & Tveit, Arnljot (2017). Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation. Thrombosis Journal.  ISSN 1477-9560.  15(1) . doi: 10.1186/s12959-017-0153-1 Fulltekst i vitenarkiv.
• Laake, Kristian; Seljeflot, Ingebjørg; Schmidt, EB; Myhre, Peder Langeland; Tveit, Arnljot; Nordseth, Jon; Arnesen, Harald & Solheim, Svein (2017). Galectin-3, a marker of cardiac remodeling, is inversely related to serum Levels of marine omega-3 fatty acids. A cross-sectional study. Journal of the Royal Society of Medicine Cardiovascular Disease.  ISSN 0959-5287.  6, s 1- 7 . doi: 10.1177/2048004017729984 Fulltekst i vitenarkiv.
• Opstad, Trine Baur; Brusletto, Berit Sletbakk; Arnesen, Harald; Pettersen, Alf Åge Reistad & Seljeflot, Ingebjørg (2017). Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease.. Immunobiology.  ISSN 0171-2985.  222(2), s 169- 175 . doi: 10.1016/j.imbio.2016.10.007 Fulltekst i vitenarkiv.
• Ritschel, Vibeke Nordmo; Shetelig, Christian; Seljeflot, Ingebjørg; Shanmuganathan, Limalanathan; HOFFMANN, PAVEL; Halvorsen, Sigrun; Arnesen, Harald; Eritsland, Jan & Andersen, Geir Øystein (2017). Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction. Scientific Reports.  ISSN 2045-2322.  7:11945(1), s 1- 9 . doi: 10.1038/s41598-017-12372-w Fulltekst i vitenarkiv.
• Unhammer Njerve, Ida; Åkra, Sissel; Weiss, Thomas W.; Solheim, Svein; Øvstebø, Reidun; Aass, Hans Christian; Byrkjeland, Rune; Arnesen, Harald & Seljeflot, Ingebjørg (2017). A Double-Blinded Randomized Study Investigating a Possible Anti-Inflammatory Effect of Saxagliptin versus Placebo as Add-On Therapy in Patients with Both Type 2 Diabetes and Stable Coronary Artery Disease. Mediators of Inflammation.  ISSN 0962-9351.  2017 . doi: 10.1155/2017/5380638 Fulltekst i vitenarkiv.
• Warlo, Ellen Mathea Kirsch; Pettersen, Alf Åge Reistad; Arnesen, Harald & Seljeflot, Ingebjørg (2017). vWF/ADAMTS13 is associated with on-aspirin residual platelet reactivity and clinical outcome in patients with stable coronary artery disease. Thrombosis Journal.  ISSN 1477-9560.  15(1) . doi: 10.1186/s12959-017-0151-3
• Byrkjeland, Rune; STENSÆTH, KNUT-HAAKON; Anderssen, Sigmund Alfred; Unhammer Njerve, Ida; Arnesen, Harald; Seljeflot, Ingebjørg & Solheim, Svein (2016). Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques. Cardiovascular Diabetology.  ISSN 1475-2840.  15(13) . doi: 10.1186/s12933-016-0336-2
• De Caterina, Raffaele; Husted, Steen E.; Wallentin, Lars; Andreotti, Felicita; Arnesen, Harald; Bachmann, Fedor; Baigent, Colin; Collet, Jean-Philippe; Halvorsen, Sigrun; Huber, Kurt; Jespersen, Jørgen; Kristensen, Steen Dalby; Lip, Gregory Y.H.; Morais, João; Rasmussen, Lars Hvilsted; Ricci, Fabrizio; Sibbing, Dirk; Siegbahn, Agneta; Storey, Robert F.; ten Berg, Jurrien M.; Verheugt, Freek W.A. & Weitz, Jeffrey I. (2016). Oral anticoagulants in coronary heart disease (Section IV): Position paper of the ESC working group on thrombosis – Task force on anticoagulants in heart disease. Thrombosis and Haemostasis.  ISSN 0340-6245.  115(4), s 685- 711 . doi: 10.1160/TH15-09-0703
• Helseth, Ragnhild; Solheim, Svein; Arnesen, Harald; Seljeflot, Ingebjørg & Opstad, Trine Baur (2016). The time course of markers of neutrophil extracellular traps in patients undergoing revascularisation for acute myocardial infarction or stable angina pectoris. Mediators of Inflammation.  ISSN 0962-9351.  2016 . doi: 10.1155/2016/2182358
• Horjen, Anja Wiedswang; Ulimoen, Sara Reinvik; Enger, Steve; Norseth, Jon; Seljeflot, Ingebjørg; Arnesen, Harald & Tveit, Arnljot (2016). Troponin I levels in permanent atrial fibrillation-impact of rate control and exercise testing. BMC Cardiovascular Disorders.  ISSN 1471-2261.  16(1) . doi: 10.1186/s12872-016-0255-x
• Horjen, Anja Wiedswang; Ulimoen, Sara Reinvik; Seljeflot, Ingebjørg; Smith, Pål; Arnesen, Harald; Norseth, Jon & Tveit, Arnljot (2016). High-sensitivity troponin I and rhythm outcome after electrical cardioversion for persistent Atrial fibrillation. Cardiology.  ISSN 0008-6312.  133(4), s 233- 238 . doi: 10.1159/000442249 Vis sammendrag

  Objectives: We hypothesised that high-sensitivity troponin I (hs-TnI) might predict long-term rhythm outcome after cardioversion for persistent atrial fibrillation (AF), and that maintenance of sinus rhythm and/or treatment with the angiotensin II type 1 receptor blocker candesartan would reduce hs-TnI levels. Methods: In a double-blind, placebo-controlled study, 171 patients referred for electrical cardioversion for AF were randomised to receive candesartan or placebo for 3-6 weeks before cardioversion and for 6 months after electrical cardioversion. Blood samples for analysis of hs-TnI (Abbott Diagnostics) were available in 129 patients at baseline and in 60 successfully cardioverted patients at study end. Results: Hs-TnI was detectable in all subjects, with a median value of 5.3 ng/l (25th percentile 3.7, 75th percentile 7.2). hs-TnI at baseline was not predictive of rhythm outcome 6 months after electrical cardioversion for persistent AF. Treatment with candesartan did not influence the levels of hs-TnI. hs-TnI was unchanged from baseline to study end in patients who maintained sinus rhythm [4.9 (3.7, 7.0) and 5.0 (4.0, 6.4) ng/l, respectively; p = 0.699). Conclusions: hs-TnI did not predict AF recurrence after cardioversion. hs-TnI levels were unchanged in patients maintaining sinus rhythm for 6 months after electrical cardioversion. hs-TnI levels were not influenced by treatment with candesartan.

• Laake, Kristian; Seljeflot, Ingebjørg; Schmidt, Erik Berg; Myhre, Peder Langeland; Tveit, Arnljot; Arnesen, Harald & Solheim, Svein (2016). Serum fatty acids, traditional risk factors and comorbidity as related to nyocardial injury in an elderly population with acute myocardial infarction. Journal of Lipids.  ISSN 2090-3030.  2016 . doi: 10.1155/2016/4945720
• Opstad, Trine Baur; Arnesen, Harald; Pettersen, Alf Åge Reistad & Seljeflot, Ingebjørg (2016). Combined Elevated Levels of the Proinflammatory Cytokines IL-18 and IL-12 Are Associated with Clinical Events in Patients with Coronary Artery Disease: An Observational Study. Metabolic Syndrome and Related Disorders.  ISSN 1540-4196.  14(5), s 242- 248 . doi: 10.1089/met.2015.0130
• Ritschel, Vibeke Nordmo; Seljeflot, Ingebjørg; Arnesen, Harald; Halvorsen, Sigrun; Eritsland, Jan; Fagerland, Morten & Andersen, Geir Øystein (2016). Circulating levels of IL-6 receptor and gp130 and long-term clinical outcomes in ST-elevation myocardial infarction. Journal of the American Heart Association.  ISSN 2047-9980.  5(6) . doi: 10.1161/JAHA.115.003014
• Unhammer Njerve, Ida; Byrkjeland, Rune; Arnesen, Harald; Åkra, Sissel; Solheim, Svein & Seljeflot, Ingebjørg (2016). Effects of long-term exercise training on adipose tissue expression of fractalkine and MCP-1 in patients with type 2 diabetes and stable coronary artery disease: A substudy of a randomized controlled trial. Diabetes, Metabolic Syndrome and Obesity.  ISSN 1178-7007.  9, s 55- 62 . doi: 10.2147/DMSO.S96299
• Andric, Tijana; Weiss, Thomas; Huber, Kurt; Arnesen, Harald & Seljeflot, Ingebjørg (2015). Effects of diet and/or n-3 fatty acid supplementation on components of the interleukin-6 trans-signalling system in elderly men. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  75(8), s 646- 651 . doi: 10.3109/00365513.2015.1063002.
• Bethke, Anne; Halvorsen, Sigrun; Bøhmer, Ellen; Abdelnoor, Michael; Arnesen, Harald & HOFFMANN, PAVEL (2015). Myocardial perfusion grade predicts final infarct size and left ventricular function in patients with ST-elevation myocardial infarction treated with a pharmaco-invasive strategy (thrombolysis and early angioplasty). EuroIntervention.  ISSN 1774-024X.  11(5), s 518- 524 . doi: 10.4244/EIJY15M04-02
• Byrkjeland, Rune; Unhammer Njerve, Ida; Anderssen, Sigmund Alfred; Arnesen, Harald; Seljeflot, Ingebjørg & Solheim, Svein (2015). Effects of exercise training on HbA1c and VO2peak in patients with type 2 diabetes and coronary artery disease: A randomised clinical trial. Diabetes & vascular disease research.  ISSN 1479-1641.  12(5), s 325- 333 . doi: 10.1177/1479164115590552
• Furenes, Eline Bredal; Opstad, Trine Baur; Solheim, Svein; Lunde, Ketil; Arnesen, Harald & Seljeflot, Ingebjørg (2015). The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation.  ISSN 0962-9351.  2014 . doi: 10.1155/2014/385901
• Hansen, Charlotte Holst; Ritschel, Vibeke Nordmo; Halvorsen, Sigrid Groven; Bjørnerheim, Reidar; Andersen, Geir Øystein; Eritsland, Jan; Arnesen, Harald & Seljeflot, Ingebjørg (2015). Markers of thrombin generation are associated with myocardial necrosis and left ventricular impairment in patients with ST-elevation myocardial infarction. Thrombosis Journal.  ISSN 1477-9560.  13(1) . doi: 10.1186/s12959-015-0061-1 Vis sammendrag

  Introduction: Platelet activation, thrombin generation and fibrin formation play important roles in intracoronary thrombus formation, which may lead to acute myocardial infarction. We investigated whether the prothrombotic markers D-dimer, pro-thrombin fragment 1 + 2 (F1 + 2) and endogenous thrombin potential (ETP) are associated with myocardial necrosis assessed by Troponin T (TnT), and left ventricular impairment assessed by left ventricular ejection fracti on (LVEF) and N-terminal pro b-type natriuretic peptide (NT-proBNP). Materials/Methods: Patients ( n = 987) with ST-elevation mycardial inf arction (STEMI) were included. Blood samples were drawn at a median time of 24 h after onset of symptoms. Results: Statistically significant correlations were found between both peak TnT and D-dimer ( p < 0.001) and F1 + 2 ( p < 0.001), and between NT-proBNP and D-dimer ( p = 0.001) and F1 + 2 ( p < 0.001). When dividing TnT and NT-proBNP levels into quartiles there were significant trends for increased levels of both markers across quartiles (all p < 0.001) D-dimer remained significantly associated with NT-proBNP after adjustments for covariates ( p = 0.001) whereas the association between NTproBNP and F1 + 2 was no longer statistically significant ( p =0.324). A significant inverse correlation was found between LVEF and D-dimer ( p < 0.001) and F1 + 2 ( p = 0.013). When dichotomizing LVEF levels at 40 %, we observed significantly higher levels of both D-dimer ( p < 0.001) and F1 + 2 ( p = 0.016) in the group with low EF ( n =147). Summary/conclusion: In our cohort of STEMI patients we demonstrated that levels of D-dimer and F1 + 2 were significantly associated with myocardial necrosis as assessed by peak TnT. High levels of these coagulation markers in patients with low LVEF and high NTproBNP may indicate a hypercoagulable state in patients with impaired myocardial function.

• Helseth, Ragnhild Merckoll; Seljeflot, Ingebjørg; Opstad, Trine Baur; Solheim, Svein; Freynhofer, M; Arnesen, Harald; Huber, Kurt & Weiss, Thomas (2015). Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction. Thrombosis Research.  ISSN 0049-3848.  135(2), s 329- 333 . doi: 10.1016/j.thromres.2014.11.028
• Helseth, Ragnhild; Weiss, Thomas; Opstad, Trine Baur; Siegbahn, Agneta; Solheim, Svein; Freynhofer, Matthias K; Huber, Kurt; Arnesen, Harald & Seljeflot, Ingebjørg (2015). Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction. Thrombosis Research.  ISSN 0049-3848.  136(6), s 1240- 1244 . doi: 10.1016/j.thromres.2015.10.005 Vis sammendrag

  Introduction Several genes are expressed in aspirated coronary thrombi in acute myocardial infarction (AMI), exhibiting dynamic changes along ischemic time. Whether soluble biomarkers reflect the local gene environment and ischemic time is unclear. We explored whether circulating biomarkers were associated with corresponding coronary thrombi genes and total ischemic time. Material and methods In 33 AMI patients undergoing percutaneous coronary intervention (PCI), blood samples were collected within 6–24 h for markers related to plaque rupture (metalloproteinase 9, tissue inhibitor of metalloproteinases 1), platelet and endothelial cell activation (P-selectin, CD40 ligand, PAR-1), hemostasis (tissue factor, tissue plasminogen activator, plasminogen activator inhibitor 1, free and total tissue factor pathway inhibitor, D-dimer, prothrombin fragment 1 + 2), inflammation (interleukin 8 and 18, fractalkine, monocyte chemoattractant protein 1 (MCP-1), CXCL1, pentraxin 3, myeloperoxidase) and galectin 3, caspase 8 and epidermal growth factor (EGF). Laboratory analyses were performed by Proximity Extension Assay (Proseek Multiplex CVD I96 × 96), ELISAs and RT-PCR. Results Only circulating P-selectin correlated to the corresponding P-selectin gene expression in thrombi (r = 0.530, p = 0.002). Plasma galectin 3, fractalkine, MCP-1 and caspase 8 correlated inversely to ischemic time (r = − 0.38–0.50, all p < 0.05), while plasma MCP-1, galectin 3 and EGF were higher at short (≤ 4 h) vs. long (> 4 h) ischemic time (all p < 0.05). Conclusions The dynamic changes in circulating mediators along ischemic time were not reflected in the profile of locally expressed genes. These observations indicate a locally confined milieu within the site of atherothrombosis, which may be important for selective therapy.

• Laake, Kristian; Seljeflot, Ingebjørg; Fagerland, Morten; Unhammer Njerve, Ida; Arnesen, Harald & Solheim, Svein (2015). Effects on serum fractalkine by diet and omega-3 fatty acid intervention: Relation to clinical outcome. Mediators of Inflammation.  ISSN 0962-9351.  2015 . doi: 10.1155/2015/373070
• Pettersen, Alf Åge Reistad; Arnesen, Harald & Seljeflot, Ingebjørg (2015). A brief review on high on-aspirin residual platelet reactivity. Vascular pharmacology.  ISSN 1537-1891.  67, s 6- 9 . doi: 10.1016/j.vph.2015.03.018
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• Bøhmer, Ellen; Kristiansen, Ivar Sønbø; Arnesen, Harald & Halvorsen, Sigrun (2014). Health-related quality of life after myocardial infarction, does choice of method make a difference?. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  48(4), s 216- 222 . doi: 10.3109/14017431.2014.923581
• Helseth, Ragnhild Merckoll; Solheim, Svein; Opstad, Trine Baur; HOFFMANN, PAVEL; Arnesen, Harald & Seljeflot, Ingebjørg (2014). The time profile of pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention. Mediators of Inflammation.  ISSN 0962-9351.  2014 . doi: 10.1155/2014/608414
• Husebye, Trygve Guttorm; Eritsland, Jan; Arnesen, Harald; Bjørnerheim, Reidar; Mangschau, Arild; Seljeflot, Ingebjørg & Andersen, Geir Øystein (2014). Association of interleukin-8 and myocardial recovery in patients with ST-elevation myocardial infarction complicated by acute heart failure. PLOS ONE.  ISSN 1932-6203.  9(11) . doi: 10.1371/journal.pone.0112359
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• Unhammer Njerve, Ida; Solheim, Svein; Lunde, Ketil; HOFFMANN, PAVEL; Arnesen, Harald & Seljeflot, Ingebjørg (2014). Fractalkine levels are elevated early after PCI-treated ST-elevation myocardial infarction; no influence of autologous bone marrow derived stem cell injection. Cytokine.  ISSN 1043-4666.  69(1), s 131- 135 . doi: 10.1016/j.cyto.2014.05.022
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• De Caterina, Raffaele; Husted, Steen; Wallentin, Lars; Andreotti, Felicita; Arnesen, Harald; Bachmann, Fedor; Baigent, Colin; Huber, Kurt; Jespersen, Jørgen; Kristensen, Steen Dalby; Lip, Gregory Y.H.; Morais, João; Rasmussen, Lars Hvilsted; Siegbahn, Agneta; Verheugt, Freek W.A. & Weitz, Jeffrey I. (2013). Parenteral anticoagulants in heart disease: Current status and perspectives (Section II) Position Paper of the ESC Working Group on Thrombosis - Task Force on Anticoagulants in Heart Disease. Thrombosis and Haemostasis.  ISSN 0340-6245.  109(5), s 769- 786 . doi: 10.1160/TH12-06-0403
• De Caterina, Raffaele; Husted, Steen; Wallentin, Lars; Andreotti, Felicita; Arnesen, Harald; Bachmann, Fedor; Baigent, Colin; Huber, Kurt; Jespersen, Jørgen; Kristensen, Steen Dalby; Lip, Gregory Y.H.; Morais, João; Rasmussen, Lars Hvilsted; Siegbahn, Agneta; Verheugt, Freek & Weitz, Jeffrey I. (2013). Vitamin K antagonist in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis- Task Force on anticoagulants in Heart Disease. Thrombosis and Haemostasis.  ISSN 0340-6245.  110(6), s 1087- 1107 . doi: 10.1160/TH13-06-0443
• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Erikssen, Gunnar; Engeseth, Kristian; Gjesdal, Knut; Kjeldsen, Sverre Erik; Arnesen, Harald; Erikssen, Jan Emil & Bodegard, Johan (2013). Low Heart Rates Predict Incident Atrial Fibrillation in Healthy Middle-Aged Men. Circulation: Arrhythmia and Electrophysiology.  ISSN 1941-3149.  6(4), s 726- 731 . doi: 10.1161/CIRCEP.113.000267
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• Husebye, Trygve Guttorm; Eritsland, Jan; Muller, Carl; Sandvik, Leiv; Arnesen, Harald; Seljeflot, Ingebjørg; Mangschau, Arild; Bjørnerheim, Reidar & Andersen, Geir Øystein (2013). Levosimendan in acute heart failure following primary percutaneous coronary intervention-treated acute ST-elevation myocardial infarction. Results from the LEAF trial: a randomized, placebo-controlled study. European Journal of Heart Failure.  ISSN 1388-9842.  15(5), s 565- 572 . doi: 10.1093/eurjhf/hfs215
• Karlsen, Anette; Svendsen, Mette; Seljeflot, Ingebjørg; Laake, Petter; Duttaroy, Asim K.; Drevon, Christian A; Arnesen, Harald; Tonstad, Serena & Blomhoff, Rune (2013). Kiwifruit decreases blood pressure and whole-blood platelet aggregation in male smokers. Journal of Human Hypertension.  ISSN 0950-9240.  27(2), s 126- 130 . doi: 10.1038/jhh.2011.116
• Opstad, Trine Baur; Pettersen, Alf Åge Reistad; Arnesen, Harald & Seljeflot, Ingebjørg (2013). The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphism predicts future clinical events in stable coronary artery disease patients. PLOS ONE.  ISSN 1932-6203.  8(9) . doi: 10.1371/journal.pone.0074498
• Solheim, Svein; Seljeflot, Ingebjørg; Lunde, Ketil; Bratseth, Vibeke; Aakhus, Svend; Forfang, Kolbjørn & Arnesen, Harald (2013). Prothrombotic markers in patients with acute myocardial infarction and left ventricular thrombus formation treated with PCI and dual antiplatelet therapy. Thrombosis Journal.  ISSN 1477-9560. . doi: 10.1186/1477-9560-11-1
• Tveit, Arnljot; Seljeflot, Ingebjørg; Smith, Pål; Arnesen, Harald & Svendsen, Jesper H. (2013). Angiotensin II blockade, YKL-40 and maintenance of sinus rhythm after electrical cardioversion for atrial fibrillation. Immunobiology.  ISSN 0171-2985.  218(10), s 1256- 1260 . doi: 10.1016/j.imbio.2013.04.014
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• Borthne, Arne Sigmund & Arnesen, Harald (2020). angiokardiografi. Store Norske Leksikon (Nettutgaven).
• Borthne, Arne Sigmund & Arnesen, Harald (2019). Pletysmografi. Store Norske Leksikon (Nettutgaven).
• Myhre, Peder Langeland; Laake, Kristian; Seljeflot, Ingebjørg; Solheim, Svein & Arnesen, Harald (2016). Forskning på eldre.. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  9(136) . doi: 10.4045/tidsskr.15.1300
• Husted, Steen; De Caterina, Raffaele; Andreotti, Felicita; Arnesen, Harald; Bachmann, Fedor; Huber, Kurt; Jespersen, Jørgen; Kristensen, Steen Dalby; Lip, Gregory Y.H.; Morais, João; Rasmussen, Lars H.; Siegbahn, Agneta; Storey, Robert F. & Weitz, Jeffrey I. (2014). Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel. Thrombosis and Haemostasis.  ISSN 0340-6245.  111(5), s 781- 782 . doi: 10.1160/TH14-03-0228
• Arnesen, Harald & Seljeflot, Ingebjørg (2013). The challenge of judging data on the effects of n-3 fatty acids in CHD. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  47(2), s 67- 68 . doi: 10.3109/14017431.2012.761348
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• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Erikssen, Gunnar; Engeseth, Kristian; Gjesdal, Knut; Kjeldsen, Sverre Erik; Arnesen, Harald; Erkssen, J. & Bodegard, Johan (2013). Predictors of atrial fibrillation differ in men with high vs low physical fitness. European Heart Journal.  ISSN 0195-668X.  34, s 1041- 1041
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• Seljeflot, Ingebjørg; Andersen, Geir Ove; Halvorsen, Sigrun; Bjørnerheim, Reidar; Eritsland, Jan & Arnesen, Harald (2013). Clopidogrel resistance in patients with ST-elevation myocardial infarction is associated with high body mass index. European Heart Journal.  ISSN 0195-668X.  34, s 882- 883
• Solheim, Svein; Helseth, Ragnhild Merckoll; HOFFMANN, PAVEL; Arnesen, Harald & Seljeflot, Ingebjørg (2013). The profile of circulating Pentraxin 3 after PCI in patients with acute myocardial infarction or angina pectoris. European Heart Journal.  ISSN 0195-668X.  34, s 1028- 1028
• Husebye, Trygve Guttorm; Eritsland, Jan; Arnesen, Harald; Seljeflot, Ingebjørg; Sandvik, Leiv; Mangschau, Arild; Bjørnerheim, Reidar & Andersen, Geir Øystein (2012). Levosimendan improves contractility in post ischemic myocardium in patients with acutely revascularised infarction complicated by decompensated heart failure. European Heart Journal.  ISSN 0195-668X.  33, s 934- 934
• Pettersen, Alf Åge Reistad; Arnesen, Harald; Opstad, Trine Baur; Bratseth, Vibeke & Seljeflot, Ingebjørg (2012). Markers of endothelial and platelet activation are associated with high on-aspirin residual platelet reactivity. European Heart Journal.  ISSN 0195-668X.  33(Supp. 1), s 306- 307

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