Hanne-Cathrin Flinstad Harbo

Professor II - Nevrologisk avdeling

English version of this page

E-post h.c.f.harbo@medisin.uio.no

Mobiltelefon +4799546680

Rom Rikshospitalet D3.3033 eller Ullevål Bygg 18, 2 etasje

Brukernavn

Besøksadresse Nevrologisk avdeling Oslo universitetssykehus

Postadresse Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

Pressebilde Last ned visittkort

Jeg er professor ved Nevrologisk avdeling, Institutt for klinisk medisin ved Universitetet i Oslo og avdelingsleder og overlege ved Nevrologisk avdeling, Nevroklinikken (NVR), Oslo universitetssykehus.

Faglige interesser

Som avdelingsleder ved Nevrologisk avdeling og professor i nevrologi ved UiO har jeg en bred interesse for hjernehelse generelt og nevrologiske tilstander spesielt. Både gjennom min nåvrende lederstilling ved Nevrologisk avdeling, OUS og min stilling som nestleder ved Institutt for klinisk medisin, Det medisinske fakultet, UiO i 2015-2018 har jeg erfaring fra mange områder.

Jeg arbeider både klinisk og forskningsmessig mest med utredning og behandling av inflammatoriske sykdommer i det sentrale nervesystemet, spesielt multippel sklerose (MS). Jeg er nå nestleder og prosjektleder i forskergruppen Multippel Sklerose ved UiO / OUS.

MS-forskningsgruppen har som mål å kartlegge forhold som påvirker utvikling og behandlingen av MS gjennom ulike former for translasjonsstudier. Vi utfører eller deltar i følgende typer studier; genetiske-, molekylære-, immunologi-, epidemiologi-, klinisk nevrologi-, nevropsykologi- , øye- og MRI-studier.

Vi har en rekke nasjonale og internasjonale samarbeidspartnere. Jeg er blant annet pt. i styringsgruppen og er arbeidspakkeleder i det EU-Horizon 2020-finansierte prosjektet "MultipleMS", samt i Biotek 2021-prosjektet "Sys4MS". Jeg er hovedkontakt for vår forskningsgruppes affiliasjon med Ospedale San Rafael, Milan, Italy og MR- forskningsnettverket for MS MAGNIMS (Magnetic Resonance Imaging in MS).

Verv

2020 - Medlem av Rådgivende utvalg for Stiftelsen Kristian Georg Jebsen
2019 - Medlem av Forskningsutvlaget for Oslo universitetssykehus
2018 - Medlem av priskomiteen for UiOs priser for forskning, utdanning, formidling og innovasjon
2018- Leder av priskomite for Monrad-Krohns pris for fremme av nerologisk forskning
2017- 2019 Convenor of International MS Genetics Consortium (IMSGC) http://imsgenetics.org/
2016-2017 Medlem av rådgivende gruppe for UiO: Livsvitenskap http://www.uio.no/forskning/satsinger/livsvitenskap/
2015-2018 Medlem av Undervisningsutvalget ved Oslo universitetssykehus
2017- Medlem av valgkomiteen for Hjernerådet
2017- Medlem av priskomiteen for Forsverg og Auries legat
2014-2017 Leder av Hjernerådet (The Norwegian Brain Council) (styremedlem fra 2013), fra 2017 medlem av rådgivende gruppe for Hjernerådet
2015-2017 Medlem av ECTRIMS council
2013 - Medlem av styringsgruppen for International MS Genetics Consortium (IMSGC).
2003 - Norsk leder/Principle Investigator i Nordic MS Genetics Network og International MS Genetics Consortium (IMSGC).

Undervisning

Jeg underviser i nevrologi på grunnstudiet i medisin ved Det medisinske fakulte, UiO.

Bakgrunn

Avdelingsleder ved Nevrologisk avdeling, Oslo uiversitetssykehus fra september 2018
Nestleder ved Institutt for klinisk medisin, Det medisinske fakultet, UiO fra januar 2015 t.o.m. august 2018.
Master Health Administration, UiO 2015
Visiting professor, University of San Fransisco, USA 2011-2012 (12 mndr)
Professor i nevrologi, Institutt for klinisk medisin, fra 2010
Leder MS forskningsgruppe OUS/UiO fra 2003- 2018
Overlege nevrologisk avdeling, OUS fra 2003 på Ullevål og fra 2016 på Rikshospitalet
Dr. med (PhD) 2003, UiO
Visiting researcher University of Cambridge, UK, 2001 (6 mndr)
Stipendiat (PhD, senere postdoc) ved Immunologisk institutt, Rikshospitalet 1997-2006
Spesialist i nevrologi 1997
Cand.med. (MD) 1988, UiO

Samarbeid

Forskningsenhet for nevrofag, Oslo University Hospital (Celius, Berge, Bos, Zwart, Toft, Dietrichs, Heuser, Taubøll, Tallaksen)
Nevroradiologisk avdeling, Oslo universitetssykehus (Beyer, Sowa, Due-Tønnesen, Bjørnerud)
NORMENT (Westlye, Andreassen)
Institute of Psychology, University of Oslo (Walhovd, Fjell, Landrø)
Norwegian MS Registry and Biobank
Institute of Medical Genetics, Oslo University Hospital (Lie)
Institute of Basal Medical Sciences, University of Oslo (Spurkland)
Nordic Multiple Sclerosis Genetics Network (Kochum, Olsson, Hillert, Oturai, Saarela)
International Multiple Sclerosis Genetics Consortium (IMSGC)
MultipleMS consortium (EU Horizon 2020-project) ( Kocum et at)
MAGNIMS by affiliation to Ospedale San Rafael, Milan, Italy
University of Cambridge Multiple Sclerosis Genetics Group (Sawcer, Ban, Compston)
University of California Berkeley (Barcellos)
University of California San Francisco (Oksenberg, Baranzini, Hauser)
University of Nantes, France (Gourraud)
Institut Biomedical Research August Pi Sunyer (IDIBAPS) Hospital Clinic of Barcelona, Spain (Villoslada)

Emneord: Genetikk, Epidemiologi, Hjerne og nervesystem, Multippel sklerose

König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Vis alle 22 forfattere av denne artikkelen] (2021). Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. s. 1–4. doi: 10.1136/jnnp-2021-327612.
Høgestøl, Einar August; Ghezzo, Samuele; Nygaard, Gro Owren; Espeseth, Thomas; Sowa, Piotr & Beyer, Mona K. [Vis alle 10 forfattere av denne artikkelen] (2021). Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Multiple Sclerosis. ISSN 1352-4585. doi: 10.1177/13524585211030212.
Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma & Tonby, Kristian [Vis alle 15 forfattere av denne artikkelen] (2021). Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. Journal of Neurology. ISSN 0340-5354. doi: 10.1007/s00415-021-10517-6. Fulltekst i vitenarkiv
Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Abrahamsen, Greger; Gjerstad, Vibeke Sundvold; Mesel Isom, Martine & Keshari, Pankaj [Vis alle 12 forfattere av denne artikkelen] (2021). Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 94(1). doi: 10.1111/sji.13050. Fulltekst i vitenarkiv
Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Kvistad, Silje Agnethe Stokke; Torkildsen, Øivind & Wergeland, Stig [Vis alle 17 forfattere av denne artikkelen] (2021). Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis. Multiple Sclerosis and Related Disorders. ISSN 2211-0348. 50. doi: 10.1016/j.msard.2021.102801. Fulltekst i vitenarkiv
Andreassen, Silje; Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Beyer, Mona K.; Ljøstad, Unn & Mygland, Åse Daasvand [Vis alle 11 forfattere av denne artikkelen] (2021). Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis. Ticks and Tick-borne Diseases. ISSN 1877-959X. 12(3), s. 1–5. doi: 10.1016/j.ttbdis.2021.101678.
Cellerino, Maria; Ivaldi, Frederico; Pardini, Matteo; Rotta, Gianluca; Vila, Gemma & Bäcker-Koduah, Priscilla [Vis alle 23 forfattere av denne artikkelen] (2020). Impact of treatment on cellular immunophenotype in MS: A cross-sectional study. Neurology: Neuroimmunology and neuroinflammation. ISSN 2332-7812. 7:e693, s. 1–13. doi: 10.1212/NXI.0000000000000693. Fulltekst i vitenarkiv
Brune, Synne; Høgestøl, Einar August; Cengija, Vanja; Berg-Hansen, Pål; Sowa, Piotr & Nygaard, Gro Owren [Vis alle 8 forfattere av denne artikkelen] (2020). LesionQuant for assessment of MRI in multiple sclerosis—A promising supplement to the visual scan inspection. Frontiers in Neurology. ISSN 1664-2295. 11:546744, s. 1–10. doi: 10.3389/fneur.2020.546744. Fulltekst i vitenarkiv
Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Vitelli, Valeria; Celius, Elisabeth Gulowsen & Luders, Torben [Vis alle 10 forfattere av denne artikkelen] (2020). CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. doi: 10.1177/2055217320978511. Fulltekst i vitenarkiv
Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Vis alle 76 forfattere av denne artikkelen] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Fulltekst i vitenarkiv
Aamodt, Anne Hege; Harbo, Hanne Flinstad; Eldøen, Guttorm; Barratt-Due, Andreas & Aukrust, Pål (2020). Hvordan påvirkes hjernen ved covid-19? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(10), s. 968–969. doi: 10.4045/tidsskr.20.0444.
Rhead, Brooke; Brorson, Ina Skaara; Berge, Tone; Adams, Cameron; Quach, H. & Moen, Stine Marit [Vis alle 18 forfattere av denne artikkelen] (2019). Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0206511.
Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Celius, Elisabeth Gulowsen; Berg-Hansen, Pål & Barcellos, Lisa F [Vis alle 9 forfattere av denne artikkelen] (2019). No differential gene expression for CD4+ T cells of MS patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. doi: 10.1177/2055217319856903.
Madireddy, Lohith; Patsopoulos, Nikolaos A.; Cotsapas, Chris; Bos, Steffan Daniel; Beecham, Ashley & McCauley, Jacob [Vis alle 64 forfattere av denne artikkelen] (2019). A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. Nature Communications. ISSN 2041-1723. 10:2236, s. 1–12. doi: 10.1038/s41467-019-09773-y. Fulltekst i vitenarkiv
Patsopoulos, Nikolaos A.; Baranzini, Sergio E.; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris & Wong, Garrett [Vis alle 154 forfattere av denne artikkelen] (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. ISSN 0036-8075. 365:eaav7188(6460), s. 1–12. doi: 10.1126/science.aav7188. Vis sammendrag
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses
Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Celius, Elisabeth Gulowsen; Berg-Hansen, Pål & Barcellos, Lisa F. [Vis alle 9 forfattere av denne artikkelen] (2019). No differential gene expression for CD4+ T cells of MS patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. 5(2). doi: 10.1177/2055217319856903. Fulltekst i vitenarkiv
Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr & Nordvik, Jan Egil [Vis alle 11 forfattere av denne artikkelen] (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, s. 1–9. doi: 10.3389/fneur.2019.00450. Fulltekst i vitenarkiv
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Vis alle 84 forfattere av denne artikkelen] (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s. 1617–1623. doi: 10.1038/s41593-019-0471-7. Fulltekst i vitenarkiv
Berge, Tone; Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Berg-Hansen, Pål & Døskeland, Anne Marie Simonne [Vis alle 10 forfattere av denne artikkelen] (2019). Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls . Clinical Proteomics. ISSN 1542-6416. 16:19, s. 1–18. doi: 10.1186/s12014-019-9241-5. Fulltekst i vitenarkiv
Benavent, Sigrid Aune de Rodez; Nygaard, Gro Owren; Nilsen, Kristian Bernhard; Etholm, Lars; Sowa, Piotr & Gustavsen, Marte Wendel [Vis alle 11 forfattere av denne artikkelen] (2019). Neurodegenerative interplay of cardiovascular autonomic dysregulation and the retina in early multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10, s. 1–9. doi: 10.3389/fneur.2019.00507. Fulltekst i vitenarkiv
Høgestøl, Einar August; Nygaard, Gro Owren; Alnæs, Dag; Beyer, Mona K.; Westlye, Lars Tjelta & Harbo, Hanne Flinstad (2019). Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 14(4). doi: 10.1371/journal.pone.0210375. Fulltekst i vitenarkiv
Mitrovic, Mitja; Patsopoulos, Nikolaos A.; Beecham, Ashley H.; Dankowski, Theresa; Goris, An & Dubois, Benedicte [Vis alle 52 forfattere av denne artikkelen] (2018). Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell. ISSN 0092-8674. 175(6), s. 1679–1687. doi: 10.1016/j.cell.2018.09.049. Fulltekst i vitenarkiv
Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke & Berg-Hansen, Pål [Vis alle 12 forfattere av denne artikkelen] (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. s. 1–12. doi: 10.1177/1352458518765671. Fulltekst i vitenarkiv
Rhead, Brooke; Brorson, Ina Skaara; Berge, Tone; Adams, Cameron; Quach, Hong & Moen, Stine Marit [Vis alle 18 forfattere av denne artikkelen] (2018). Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients. PLOS ONE. ISSN 1932-6203. 13(10). doi: 10.1371/journal.pone.0206511. Fulltekst i vitenarkiv
Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Andreassen, Silje; Paulsen, Else Quist; Eikeland, Randi & Ljøstad, Unn [Vis alle 12 forfattere av denne artikkelen] (2018). Imaging in Lyme neuroborreliosis. Insight into Imaging. ISSN 1869-4101. 9(5), s. 833–844. doi: 10.1007/s13244-018-0646-x. Fulltekst i vitenarkiv
Akhmadeev, Konstantin; Houssein, Aya; Moussaoui, Said; Høgestøl, Einar August; Tutturen, Ingerid Maria Voorham & Harbo, Hanne Flinstad [Vis alle 10 forfattere av denne artikkelen] (2018). SVM-based tool to detect patients with multiple sclerosis using a commercial EMG sensor. Proceedings of the IEEE Sensor Array and Multichannel Signal Processing Workshop. ISSN 1551-2282. 2018-July, s. 376–379. doi: 10.1109/SAM.2018.8448391. Fulltekst i vitenarkiv
Page, Christian; Vos, Linda; Rounge, Trine Ballestad; Harbo, Hanne Flinstad & Kulle, Bettina (2018). Assessing genome-wide significance for the detection of differentially methylated regions. Statistical Applications in Genetics and Molecular Biology. ISSN 1544-6115. 17(6). doi: 10.1515/sagmb-2017-0050. Fulltekst i vitenarkiv
Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco & Gomez-Cabrero, David [Vis alle 48 forfattere av denne artikkelen] (2018). DNA methylation as a mediator of HLA-DRB1 15:01 and a protective variant in multiple sclerosis. Nature Communications. ISSN 2041-1723. 9(1), s. 1–15. doi: 10.1038/s41467-018-04732-5. Fulltekst i vitenarkiv
Olafsson, Sigurgeir; Olafsson, S.; Stridh, Pernilla; Stridh, P.; Bos, Steffan Daniel & Ingason, Andrés [Vis alle 72 forfattere av denne artikkelen] (2017). Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations. NPJ GENOMIC MEDICINE. ISSN 2056-7944. 2. doi: 10.1038/s41525-017-0027-2. Fulltekst i vitenarkiv Vis sammendrag
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (P = 1.6 x 10(-7), 4.3 x 10(-9)) we used primary biliary cirrhosis as a proxy-phenotype for multiple sclerosis, the idea being that variants conferring risk of primary biliary cirrhosis have a prior probability of conferring risk of multiple sclerosis. We tested 255 variants forming the primary biliary cirrhosis-polygenic risk score and found seven multiple sclerosis-associating variants not correlated with any previously established multiple sclerosis variants. Most of the variants discovered are close to or within immune-related genes. One is a low-frequency missense variant in TYK2, another is a missense variant in MTHFR that reduces the function of the encoded enzyme affecting methionine metabolism, reported to be dysregulated in multiple sclerosis brain.
Sowa, Piotr; Nygaard, Gro Owren; Bjørnerud, Atle; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad & Beyer, Mona K. (2017). Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis. Neuroradiology. ISSN 0028-3940. 59(7), s. 655–664. doi: 10.1007/s00234-017-1849-4. Fulltekst i vitenarkiv
Hedström, Anna Karin; Katsoulis, Michail; Hössjer, Ola; Bomfim, Izaura L.; Oturai, Annette & Søndergaard, Helle Bach [Vis alle 19 forfattere av denne artikkelen] (2017). The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. European Journal of Epidemiology (EJE). ISSN 0393-2990. 32 , s. 909–919. doi: 10.1007/s10654-017-0250-2. Fulltekst i vitenarkiv
de Rodez Benavent, Sigrid Aune; Nygaard, Gro Owren; Harbo, Hanne Flinstad; Tønnesen, Siren; Sowa, Piotr & Landrø, Nils Inge [Vis alle 13 forfattere av denne artikkelen] (2017). Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients. Brain and Behavior. ISSN 2162-3279. 7. doi: 10.1002/brb3.717. Fulltekst i vitenarkiv
Gustavsen, Marte Wendel; Celius, Elisabeth Gulowsen; Winsvold, Bendik K S; Moen, Stine Marit; Nygaard, Gro Owren & Berg-Hansen, Pål [Vis alle 9 forfattere av denne artikkelen] (2016). Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. 2, s. 1–4. doi: 10.1177/2055217316682976. Fulltekst i vitenarkiv
Keshavan, Anisha; Paul, Friedemann; Beyer, Mona K.; Zhu, Alyssa H.; Papinutto, Nico & Shinohara, Russell T. [Vis alle 56 forfattere av denne artikkelen] (2016). Power estimation for non-standardized multisite studies. NeuroImage. ISSN 1053-8119. 134, s. 281–294. doi: 10.1016/j.neuroimage.2016.03.051.
Bos, Steffan Daniel; Berge, Tone; Celius, Elisabeth Gulowsen & Harbo, Hanne Flinstad (2016). From genetic associations to functional studies in multiple sclerosis. European Journal of Neurology. ISSN 1351-5101. 23(5), s. 847–853. doi: 10.1111/ene.12981.
Keshari, Pankaj; Harbo, Hanne Flinstad; Myhr, Kjell-Morten; Aarseth, Jan Harald; Bos, Steffan Daniel & Berge, Tone (2016). Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood. BMC Genetics. ISSN 1471-2156. 17(1). doi: 10.1186/s12863-016-0367-4.
Wang, Yunpeng; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Thompson, Wesley K.; Schork, Andrew J. & Bettella, Francesco [Vis alle 14 forfattere av denne artikkelen] (2016). Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors. Multiple Sclerosis. ISSN 1352-4585. 22(14), s. 1783–1793. doi: 10.1177/1352458516635873.
Berge, Tone; Leikfoss, Ingvild Sørum; Brorson, Ina Skaara; Bos, Steffan Daniel; Page, Christian & Gustavsen, Marte Wendel [Vis alle 13 forfattere av denne artikkelen] (2016). The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by Vitamin D in CD4+ T cells. Genes and Immunity. ISSN 1466-4879. 17(2), s. 118–127. doi: 10.1038/gene.2015.61.
Seldin, Michael F.; Alkhairy, Omar K; Lee, Annette T.; Lamb, Janine; Sussman, Jon & Pirskanen-Matell, Ritva [Vis alle 19 forfattere av denne artikkelen] (2015). Genome-wide association study of late-onset myasthenia gravis: Confirmation of TNFRSF11A and identification of ZBTB10 and three distinct HLA associations. Molecular medicine (Cambridge, Mass. Print). ISSN 1076-1551. 21, s. 769–781. doi: 10.2119/molmed.2015.00232. Vis sammendrag
To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide polymorphisms (SNPs) in 532 LOMG cases (anti–acetylcholine receptor [AChR] antibody positive; onset age ≥50 years) and 2,128 controls matched for sex and population substructure. The data confirm reported TNFRSF11A associations (rs4574025, P = 3.9 × 10–7, odds ratio [OR] 1.42) and identify a novel candidate gene, ZBTB10, achieving genome-wide significance (rs6998967, P = 8.9 × 10–10, OR 0.53). Several other SNPs showed suggestive significance including rs2476601 (P = 6.5 × 10–6, OR 1.62) encoding the PTPN22 R620W variant noted in early-onset myasthenia gravis (EOMG) and other autoimmune diseases. In contrast, EOMG-associated SNPs in TNIP1 showed no association in LOMG, nor did other loci suggested for EOMG. Many SNPs within the major histocompatibility complex (MHC) region showed strong associations in LOMG, but with smaller effect sizes than in EOMG (highest OR ~2 versus ~6 in EOMG). Moreover, the strongest associations were in opposite directions from EOMG, including an OR of 0.54 for DQA1*05:01 in LOMG (P = 5.9 × 10–12) versus 2.82 in EOMG (P = 3.86 × 10–45). Association and conditioning studies for the MHC region showed three distinct and largely independent association peaks for LOMG corresponding to (a) MHC class II (highest attenuation when conditioning on DQA1), (b) HLA-A and (c) MHC class III SNPs. Conditioning studies of human leukocyte antigen (HLA) amino acid residues also suggest potential functional correlates. Together, these findings emphasize the value of subgrouping myasthenia gravis patients for clinical and basic investigations and imply distinct predisposing mechanisms in LOMG.
Sowa, Piotr; Bjørnerud, Atle; Nygaard, Gro Owren; Damangir, Soheil; Spulber, Gabriela & Celius, Elisabeth Gulowsen [Vis alle 9 forfattere av denne artikkelen] (2015). Reduced perfusion in white matter lesions in multiple sclerosis. European Journal of Radiology. ISSN 0720-048X. 84(12), s. 2605–2612. doi: 10.1016/j.ejrad.2015.09.007.
Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H.; Dilthey, Alexander T.; Xifara, Dionysia K. & Ban, Maria [Vis alle 55 forfattere av denne artikkelen] (2015). Class II HLA interactions modulate genetic risk for multiple sclerosis. Nature Genetics. ISSN 1061-4036. 47(10), s. 1107–1113. doi: 10.1038/ng.3395.
Nygaard, Gro Owren; Celius, Elisabeth Gulowsen; de Rodez Benavent, Sigrid Aune; Sowa, Piotr; Gustavsen, Marte Wendel & Fjell, Anders Martin [Vis alle 9 forfattere av denne artikkelen] (2015). A longitudinal study of disability, cognition and gray matter atrophy in early multiple sclerosis patients according to evidence of disease activity. PLOS ONE. ISSN 1932-6203. 10(8). doi: 10.1371/journal.pone.0135974. Fulltekst i vitenarkiv
Page, Christian; Baranzini, Sergio E.; Mevik, Bjørn-Helge; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Kulle, Bettina (2015). Assessing the Power of Exome Chips. PLOS ONE. ISSN 1932-6203. 10(10). doi: 10.1371/journal.pone.0139642. Fulltekst i vitenarkiv
Nygaard, Gro Owren; de Rodez Benavent, Sigrid Aune; Harbo, Hanne Flinstad; Laeng, Bruno; Sowa, Piotr & Damangir, Soheil [Vis alle 13 forfattere av denne artikkelen] (2015). Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis. Multiple Sclerosis and Related Disorders. ISSN 2211-0348. 4(6), s. 585–589. doi: 10.1016/j.msard.2015.08.003.
Goris, An; Pauwels, Ine; Gustavsen, Marte Wendel; Van Son, Brechtje; Hilven, Kelly & Bos, Steffan Daniel [Vis alle 46 forfattere av denne artikkelen] (2015). Genetic variants are major determinants of CSF antibody levels in multiple sclerosis. Brain. ISSN 0006-8950. 138(3), s. 632–643. doi: 10.1093/brain/awu405.
Leikfoss, Ingvild Sørum; Keshari, Pankaj Kumar; Gustavsen, Marte Wendel; Bjølgerud, Anja; Brorson, Ina Skaara & Celius, Elisabeth Gulowsen [Vis alle 10 forfattere av denne artikkelen] (2015). Multiple sclerosis risk allele in CLEC16A acts as an expression quantitative trait locus for CLEC16A and SOCS1 in CD4+ T cells. PLOS ONE. ISSN 1932-6203. 10>e0132957(7). doi: 10.1371/journal.pone.0132957. Fulltekst i vitenarkiv
Bos, Steffan Daniel; Page, Christian; Kulle, Bettina; Elboudwarej, Emon; Gustavsen, Marte Wendel & Briggs, Farren [Vis alle 12 forfattere av denne artikkelen] (2015). Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0117403.
Sundal, Christina Heidemann; Baker, Matt C.; Karrenbauer, Virginija Danylaité; Gustavsen, Marte Wendel; Bedri, Sahl Khalid & Glaser, Anna [Vis alle 15 forfattere av denne artikkelen] (2015). Hereditary diffuse leukoencephalopathy with spheroids with phenotype of primary progressive multiple sclerosis. European Journal of Neurology. ISSN 1351-5101. 22(2), s. 328–333. doi: 10.1111/ene.12572.
Westerlind, Helga; Imrell, Kerstin; Ramanujam, Ryan; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen & Harbo, Hanne Flinstad [Vis alle 13 forfattere av denne artikkelen] (2015). Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort. European Journal of Human Genetics. ISSN 1018-4813. 23(5), s. 688–692. doi: 10.1038/ejhg.2014.155. Fulltekst i vitenarkiv
Berg-Hansen, Pål; Moen, Stine Marit; Sandvik, Leiv; Harbo, Hanne Flinstad; Bakken, Inger Johanne & Stoltenberg, Camilla [Vis alle 7 forfattere av denne artikkelen] (2015). Prevalence of multiple sclerosis among immigrants in Norway. Multiple Sclerosis. ISSN 1352-4585. 21(6), s. 695–702. doi: 10.1177/1352458514554055.
Nygaard, Gro Owren; Walhovd, Kristine B; Sowa, Piotr; Chepkoech, Joy-Loi; Bjørnerud, Atle & Due-Tønnessen, Paulina [Vis alle 14 forfattere av denne artikkelen] (2015). Cortical thickness and surface area relate to specific symptoms in early relapsing−remitting multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 21(4), s. 402–414. doi: 10.1177/1352458514543811.
Eriksen, Agnete Bratsberg; Berge, Tone; Gustavsen, Marte Wendel; Leikfoss, Ingvild Sørum; Bos, Steffan Daniel & Spurkland, Anne [Vis alle 8 forfattere av denne artikkelen] (2015). Retinoic acid enhances the levelels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 278, s. 11–18. doi: 10.1016/j.jneuroim.2014.11.019.
Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ & Mattingsdal, Morten [Vis alle 18 forfattere av denne artikkelen] (2015). Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry. ISSN 1359-4184. 20(2), s. 207–214. doi: 10.1038/mp.2013.195. Fulltekst i vitenarkiv
Berge, Tone & Harbo, Hanne Flinstad (2014). Fra identifikasjon til karakterisering av CLEC16A – et mottagelighetsgen for multippel sklerose. Best Practice. ISSN 1329-1874.
Goris, An; Van Setten, Jessica; Diekstra, Frank; Ripke, Stephan; Patsopoulos, Nikolaos A. & Sawcer, Stephen [Vis alle 141 forfattere av denne artikkelen] (2014). No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Human Molecular Genetics. ISSN 0964-6906. 23(7), s. 1916–1922. doi: 10.1093/hmg/ddt574.
Damotte, V; Guillot-Noel, Lena; Patsopoulos, Nikolaos A.; Madireddy, L; Behi, M El & Ban, Maria [Vis alle 128 forfattere av denne artikkelen] (2014). A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes and Immunity. ISSN 1466-4879. 15, s. 126–132. doi: 10.1038/gene.2013.70.
Avidan, Nili; Panse, Rozen Le; Harbo, Hanne Flinstad; Bernasconi, Pia; Poulas, Konstantinos & Ginzburg, Elizabeta [Vis alle 28 forfattere av denne artikkelen] (2014). VAV1 and BAFF, via NFκB pathway, are genetic risk factors for myasthenia gravis. Annals of clinical and translational neurology. ISSN 2328-9503. 1(5), s. 329–339. doi: 10.1002/acn3.51.
Gustavsen, Marte Wendel; Page, Christian; Moen, Stine Marit; Bjølgerud, Anja; Berg-Hansen, Pål & Nygaard, Gro Owren [Vis alle 10 forfattere av denne artikkelen] (2014). Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study. BMC Neurology. ISSN 1471-2377. 14(1). doi: 10.1186/s12883-014-0196-x. Fulltekst i vitenarkiv
Berg-Hansen, Pål; Moen, Stine Marit; Harbo, Hanne Flinstad & Celius, Elisabeth Gulowsen (2014). High prevalence and no latitude gradient of multiple sclerosis in Norway. Multiple Sclerosis. ISSN 1352-4585. 20(13), s. 1780–1782. doi: 10.1177/1352458514525871.
Sundqvist, Emilie; Buck, Dorothea; Warnke, Clemens; Albrecht, Eva; Gieger, Christian & Khademi, Mohsen [Vis alle 41 forfattere av denne artikkelen] (2014). JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants. PLoS Pathogens. ISSN 1553-7366. 10(4). doi: 10.1371/journal.ppat.1004084.
Gustavsen, Marte Wendel; Viken, Marte K; Celius, Elisabeth Gulowsen; Berge, Tone; Mero, Inger-Lise & Berg-Hansen, Pål [Vis alle 17 forfattere av denne artikkelen] (2014). Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general. Journal of Neuroimmunology. ISSN 0165-5728. 274(1-2), s. 174–179. doi: 10.1016/j.jneuroim.2014.06.024.
Harbo, Hanne Flinstad; Isobe, Noriko; Berg-Hansen, Pål; Bos, Steffan Daniel; Caillier, Stacy & Gustavsen, Marte Wendel [Vis alle 11 forfattere av denne artikkelen] (2014). Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 20(6), s. 660–668. doi: 10.1177/1352458513506503.
Leikfoss, Ingvild Sørum; Mero, Inger-Lise; Dahle, Maria Krudtaa; Lie, Benedicte Alexandra; Harbo, Hanne Flinstad & Spurkland, Anne [Vis alle 7 forfattere av denne artikkelen] (2013). Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. Genes and Immunity. ISSN 1466-4879. 14(1), s. 62–66. doi: 10.1038/gene.2012.52.
Baranzini, SE; Celius, E.G.; Elovaara, I; Harbo, HF; Hillert, J & Myhr, Kjell-Morten [Vis alle 84 forfattere av denne artikkelen] (2013). Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. American Journal of Human Genetics. ISSN 0002-9297. s. 854–865. doi: 10.1016/j.ajhg.2013.04.019.
Rosella, Mechelli; Renato, Umeton; Policano, Claudia; Annibali, Viviana; Giulia, Coarelli & Ricigliano, Vito A. G. [Vis alle 55 forfattere av denne artikkelen] (2013). A ‘‘candidate-interactome’’ aggregate analysis of genome-wide association data in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 8(5). doi: 10.1371/journal.pone.0063300.
Isobe, Noriko; Gourraud, Pierre-Antoine; Harbo, Hanne Flinstad; Caillier, Stacy; Santaniello, A & Khankhanian, Pouya [Vis alle 17 forfattere av denne artikkelen] (2013). Genetic risk variants in African Americans With multiple sclerosis. Neurology. ISSN 0028-3878. 81(3), s. 219–227. doi: 10.1212/WNL.0b013e31829bfe2f.
Leone, Maurizio A.; Barizzone, Nadia; Esposito, Federica; Lucenti, Ausiliatrice; Harbo, Hanne Flinstad & Goris, An [Vis alle 21 forfattere av denne artikkelen] (2013). Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients. PLOS ONE. ISSN 1932-6203. 8(6). doi: 10.1371/journal.pone.0064408.
Harbo, Hanne Flinstad; Gold, Ralf & Tintore, Mar (2013). Sex and gender issues in multiple sclerosis. Therapeutic Advances in Neurological Disorders (TAND). ISSN 1756-2856. 6(4), s. 237–248. doi: 10.1177/1756285613488434.
Berg-Hansen, Pål; SMESTAD, CATHRINE; Sandvik, Leiv; Harbo, Hanne Flinstad & Celius, Elisabeth Gulowsen (2013). Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway. European Journal of Neurology. ISSN 1351-5101. 20(12), s. 1546–1552. doi: 10.1111/ene.12227.
Beecham, Ashley H.; Patsopoulos, NA; Xifara, DK; Davis, MF; Kemppinen, A & Cotsapas, C [Vis alle 193 forfattere av denne artikkelen] (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics. ISSN 1061-4036. 45(11), s. 1353–1360. doi: 10.1038/ng.2770.
Ban, Maria; Caillier, Stacy; Mero, Inger-Lise; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen & Aarseth, Jan Harald [Vis alle 12 forfattere av denne artikkelen] (2013). No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Annals of Neurology. ISSN 0364-5134. 73(3), s. 430–432. doi: 10.1002/ana.23833.
Berge, Tone; Leikfoss, Ingvild Sørum & Harbo, Hanne Flinstad (2013). From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. International Journal of Molecular Sciences. ISSN 1422-0067. 14(3), s. 4476–4497. doi: 10.3390/ijms14034476.
Mero, Inger-Lise; Gustavsen, Marte Wendel; Sæther, Hanne Skarpodde; Flåm, Siri Tennebø; Berg-Hansen, Pål & Søndergaard, Helle Bach [Vis alle 22 forfattere av denne artikkelen] (2013). Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. PLOS ONE. ISSN 1932-6203. 8(3). doi: 10.1371/journal.pone.0058352.
Høglund, Rune Alexander; Holmøy, Trygve; Harbo, Hanne Flinstad & Maghazachi, Azzam (2013). A One Year Follow-Up Study of Natural Killer and Dendritic Cells Activities in Multiple Sclerosis Patients Receiving Glatiramer Acetate (GA). PLOS ONE. ISSN 1932-6203. 8(4). doi: 10.1371/journal.pone.0062237.
Maniaol, Angelina; Boldingh, Marion Ingeborg; Brunborg, Cathrine; Harbo, Hanne Flinstad & Tallaksen, Chantal (2013). Smoking and socio-economic status may affect myasthenia gravis. European Journal of Neurology. ISSN 1351-5101. 20(3), s. 453–460. doi: 10.1111/j.1468-1331.2012.03843.x.
Brambilla, Paola; Esposito, Federica; Lindström, Eva S.; Sorosina, Melissa; Giacalone, Giacomo & Clarelli, Ferdinando [Vis alle 22 forfattere av denne artikkelen] (2012). Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans. Neuroscience Letters. ISSN 0304-3940. 530(2), s. 155–160. doi: 10.1016/j.neulet.2012.10.008.
Martinelli-Boneschi, Filippo; Esposito, Federica; Brambilla, Paola; Lindström, Eva S.; Lavorgna, Giovanni & Stankovich, Jim [Vis alle 23 forfattere av denne artikkelen] (2012). A genome-wide association study in progressive multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 18(10), s. 1384–1394. doi: 10.1177/1352458512439118.
Gregersen, Peter K.; Kosoy, Roman; Lee, Annette T.; Lamb, Janine; Sussman, Jon & McKee, David [Vis alle 29 forfattere av denne artikkelen] (2012). Risk for Myasthenia Gravis Maps to a 151Pro!Ala Change in TNIP1 and to Human Leukocyte Antigen-B*08. Annals of Neurology. ISSN 0364-5134. 72(6), s. 927–935. doi: 10.1002/ana.23691.
Link, Jenny; Kockum, Ingrid; Lorentzen, Åslaug Rudjord; Lie, Benedicte Alexandra; Celius, Elisabeth Gulowsen & Westerlind, Helga [Vis alle 12 forfattere av denne artikkelen] (2012). Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis. PLOS ONE. ISSN 1932-6203. 7(5:e36779). doi: 10.1371/journal.pone.0036779.
Gourraud, Pierre-Antoine; Harbo, Hanne Flinstad; Hauser, Stephen L & Baranzini, Sergio E. (2012). The genetics of multiple sclerosis: an up-to-date review. Immunological Reviews. ISSN 0105-2896. 248, s. 87–103. doi: 10.1111/j.1600-065X.2012.01134.x.
Maniaol, Angelina; Elsais, Ahmed; Lorentzen, Åslaug Rudjord; Owe, Jone Furulund; Viken, Marte K & Sæther, Hanne Skarpodde [Vis alle 17 forfattere av denne artikkelen] (2012). Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population. PLOS ONE. ISSN 1932-6203. 7(5). doi: 10.1371/journal.pone.0036603. Fulltekst i vitenarkiv
Mero, Inger-Lise; SMESTAD, CATHRINE; Lie, Benedicte Alexandra; Lorentzen, Åslaug Rudjord; Sandvik, Leiv & Landrø, Nils Inge [Vis alle 10 forfattere av denne artikkelen] (2012). Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course. Journal of Neuroimmunology. ISSN 0165-5728. 244(1-2), s. 107–110. doi: 10.1016/j.jneuroim.2012.01.011.
Harbo, Hanne Flinstad & Mero, Inger-Lise (2012). From genes to characteristics of multiple sclerosis. Acta Neurologica Scandinavica. ISSN 0001-6314. 126, s. 76–83. doi: 10.1111/ane.12027.
Harbo, Hanne Flinstad & Mero, Inger-Lise (2012). From genes to characteristics of multiple sclerosis. Acta Neurologica Scandinavica, Supplementum. ISSN 0065-1427. 126, s. 76–83. doi: 10.1111/ane.12027.
Harbo, Hanne Flinstad; Lorentzen, Åslaug Rudjord; Lie, Benedicte Alexandra; Celius, Elisabeth Gulowsen & Spurkland, Anne (2011). Nytt genkart for multippel sklerose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 131(21), s. 2126–2130. doi: 10.4045/tidsskr.10.0823.
Hansen, Bettina; Oturai, Annette Bang; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Nissen, Kari K. & Laska, Magdalena J. [Vis alle 9 forfattere av denne artikkelen] (2011). Genetic Association of Multiple Sclerosis with the Marker rs391745 near the Endogenous Retroviral Locus HERV-Fc1: Analysis of Disease Subtypes. PLOS ONE. ISSN 1932-6203. 6(10). doi: 10.1371/journal.pone.0026438.
Søndergaard, Helle Bach; Sellebjerg, Finn; Hillert, Jan; Olsson, Tomas; Kockum, Ingrid & Lindén, Magdalena [Vis alle 14 forfattere av denne artikkelen] (2011). Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655. European Journal of Human Genetics. ISSN 1018-4813. 19(10), s. 1100–1103. doi: 10.1038/ejhg.2011.88.
Pandya, Abhilash D.; Al-Jaderi, Zaidoon; Høglund, Rune Alexander; Holmøy, Trygve; Harbo, Hanne Flinstad & Norgauer, Johannes [Vis alle 7 forfattere av denne artikkelen] (2011). Identification of Human NK17/NK1 Cells. PLOS ONE. ISSN 1932-6203. 6(10). doi: 10.1371/journal.pone.0026780.
Lundström, Wangko; Greiner, Eva; Lundmark, Frida; Westerlind, Helga; SMESTAD, CATHRINE & Lorentzen, Åslaug Rudjord [Vis alle 13 forfattere av denne artikkelen] (2011). No influence on disease progression of non-HLA susceptibility genes in MS. Journal of Neuroimmunology. ISSN 0165-5728. 237(1-2), s. 98–100. doi: 10.1016/j.jneuroim.2011.05.003.
Sawcer, S; Hellenthal, G; Pirinen, M; Spencer, CCA; Patsopoulos, NA & Moutsianas, L [Vis alle 242 forfattere av denne artikkelen] (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. ISSN 0028-0836. 476(7359), s. 214–219. doi: 10.1038/nature10251.
Burgunder, Jean-Marc; Schöls, Ludger; Baets, Jonathan; Andersen, Peter Munch; Gasser, Thomas & Szolnoki, Zoltan [Vis alle 18 forfattere av denne artikkelen] (2011). EFNS guidelines for the molecular diagnosis of neurogenetic disorders: motoneuron, peripheral nerve and muscle disorders. European Journal of Neurology. ISSN 1351-5101. 18(2), s. 207–E20. doi: 10.1111/j.1468-1331.2010.03069.x.
Mero, Inger-Lise; Ban, Maria; Lorentzen, Åslaug Rudjord; SMESTAD, CATHRINE; Celius, Elisabeth Gulowsen & Sæther, Hanne Skarpodde [Vis alle 18 forfattere av denne artikkelen] (2011). Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus. Genes and Immunity. ISSN 1466-4879. 12(3), s. 191–198. doi: 10.1038/gene.2010.59.
Burgunder, J-M.; Finsterer, J.; Szolnoki, Z.; Fontaine, B.; Baets, J. & Van Broeckhoven, C. [Vis alle 17 forfattere av denne artikkelen] (2010). EFNS guidelines on the molecular diagnosis of channelopathies, epilepsies, migraine, stroke, and dementias. European Journal of Neurology. ISSN 1351-5101. 17(5), s. 641–648. doi: 10.1111/j.1468-1331.2010.02985.x.
Burgunder, JM; Et al, More authors; Tallaksen, Chantal & Harbo, Hanne Flinstad (2010). EFNS guidelines for the molecular diagnosis of neurodegenerative disorders:motoneuron, peripheral nerve and muscle disorders. European Journal of Neurology. ISSN 1351-5101. 18, s. 207–217. doi: 10.1111/j.468-1331.2010.03069.x.
Beyeen, AD; Adzemovic, Milena Z.; Öckinger, Johan; Sridh, Pernilla; Et al, More authors & Becanovic, Kristina [Vis alle 16 forfattere av denne artikkelen] (2010). IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation. Journal of Immunology. ISSN 0022-1767. 185(11), s. 6883–6890. doi: 10.4049/jimmunol.1001392.
Lorentzen, Åslaug Rudjord; Melum, Espen; Ellinghaus, Eva; Smestad, Cathrine; Mero, Inger-Lise & Aarseth, Jan Harald [Vis alle 12 forfattere av denne artikkelen] (2010). Association to the Glypican-5 gene in multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 226(1-2), s. 194–197. doi: 10.1016/j.jneuroim.2010.07.003.
Link, Jenny; Lorentzen, Åslaug Rudjord; Kochum, Ingrid; Duvefelt, Kristina; Lie, Benedicte Alexandra & Celius, Elisabeth Gulowsen [Vis alle 9 forfattere av denne artikkelen] (2010). Two HLA class I genes independently associated with multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 226(1-2), s. 172–176. doi: 10.1016/j.jneuroim.2010.07.006.
Esposito, Floriana; Patsopoulos, NA; Cepok, Sabine; Kockum, I; Leppa, V & Booth, DR [Vis alle 69 forfattere av denne artikkelen] (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity. ISSN 1466-4879. 11(5), s. 397–405. doi: 10.1038/gene.2010.28.
Harbo, Hanne Flinstad; Riccio, Maria Elena; Lorentzen, Åslaug Rudjord; Utsi, Egil; Myhr, Kjell-Morten & Mellgren, Svein Ivar [Vis alle 10 forfattere av denne artikkelen] (2010). Norwegian Sami differs significantly from other Norwegians according to their HLA profile. Tissue Antigens. ISSN 0001-2815. 75(3), s. 207–217. doi: 10.1111/j.1399-0039.2009.01425.x.
Nohra, R; Beyeen, A.D.; Guo, JP; Khademi, M; Sundqvist, E & Hedreul, M [Vis alle 17 forfattere av denne artikkelen] (2010). RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes and Immunity. ISSN 1466-4879. 11(4), s. 279–293. doi: 10.1038/gene.2009.111.
Gasser, T; Finsterer, Josef; Baets, J; Van Broeckhoven, C; Di Donato, S & Fontaine, B [Vis alle 18 forfattere av denne artikkelen] (2010). EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias. European Journal of Neurology. ISSN 1351-5101. 17(2), s. 179–188. doi: 10.1111/j.1468-1331.2009.02873.x.
Mero, Inger-Lise; Lorentzen, Åslaug Rudjord; SMESTAD, CATHRINE; Ban, Maria; Celius, Elisabeth Gulowsen & Aarseth, Jan [Vis alle 22 forfattere av denne artikkelen] (2010). A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. European Journal of Human Genetics. ISSN 1018-4813. 18(4), s. 502–504. doi: 10.1038/ejhg.2009.195.
Jakkula, Eveliina; Leppa, Virpi; Sulonen, Anna-Maija; Varilo, Teppo; Kallio, Suvi & Kemppinen, Anu [Vis alle 29 forfattere av denne artikkelen] (2010). Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene. American Journal of Human Genetics. ISSN 0002-9297. 86(2), s. 285–291. doi: 10.1016/j.ajhg.2010.01.017.
Jagodic, Maja; Colacios, Celine; Nohra, Rita; Dejean, Anne S.; Beyeen, Amennai Daniel & Khademi, Mohsen [Vis alle 37 forfattere av denne artikkelen] (2009). A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Science Translational Medicine. ISSN 1946-6234. 1(10). doi: 10.1126/scitranslmed.3000278.
Ban, Maria; Booth, David R; Heard, Robert N; Stewart, Graeme J; Goris, An & Dobosi, Rita [Vis alle 33 forfattere av denne artikkelen] (2009). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes and Immunity. ISSN 1466-4879. 10(1), s. 11–14. doi: 10.1038/gene.2008.83. Vis sammendrag
Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other related conditions. On the basis of this hypothesis, we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10,296 unrelated controls. Two of these seven SNPs showed evidence of association with multiple sclerosis; that is rs12708716 from the CLEC16A gene (P=1.6 x 10(-16)) and rs763361 from the CD226 gene (P=5.4 x 10(-8)). These findings thereby identify two additional multiple sclerosis susceptibility genes and lend support to the notion of autoimmune susceptibility genes.
Harbo, Hanne Flinstad; Finsterer, J; Baets, J; Van Broeckhoven, C; Di Donato, S & Fontaine, B [Vis alle 18 forfattere av denne artikkelen] (2009). EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias. European Journal of Neurology. ISSN 1351-5101. 16(7), s. 777–785. doi: 10.1111/j.1468-1331.2009.02646.x.
Lorentzen, Åslaug Rudjord; Karlsen, TH; Olsson, M; Smestad, C; Mero, IL & Woldseth, B [Vis alle 13 forfattere av denne artikkelen] (2009). Killer Immunoglobulin-like Receptor Ligand HLA-Bw4 Protects Against Multiple Sclerosis. Annals of Neurology. ISSN 0364-5134. 65(6), s. 658–666. doi: 10.1002/ana.21695.
Ban, M; Goris, A; Lorentzen, Åslaug Rudjord; Baker, A; Mihalova, T & Ingram, G [Vis alle 31 forfattere av denne artikkelen] (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics. ISSN 1018-4813. 17(10), s. 1309–1313. doi: 10.1038/ejhg.2009.41.
Mero, Inger Lise; Lorentzen, Åslaug Rudjord; Ban, Maria; SMESTAD, CATHRINE; Celius, Elisabeth G & Aarseth, Jan [Vis alle 21 forfattere av denne artikkelen] (2009). A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/ejhg.2009.195.
Kallio, SP; Jakkula, E; Purcell, S; Suvela, M; Koivisto, K & Tienari, PJ [Vis alle 22 forfattere av denne artikkelen] (2009). Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Human Molecular Genetics. ISSN 0964-6906. 18(9), s. 1670–1683. doi: 10.1093/hmg/ddp073.
Kemppinen, Anu; Suvela, M; Tienari, PJ; Elovaara, I; Koivisto, K & Pirttila, T [Vis alle 18 forfattere av denne artikkelen] (2009). MYO9B polymorphisms in multiple sclerosis. European Journal of Human Genetics. ISSN 1018-4813. 17(6), s. 840–843. doi: 10.1038/ejhg.2008.251.
Finsterer, Josef; Harbo, Hanne Flinstad; Baets, J; Van Broeckhoven, Cathrine; Di Donato, S & Fontaine, B [Vis alle 18 forfattere av denne artikkelen] (2009). EFNS guidelines on the molecular diagnosis of mitochondrial disorders. European Journal of Neurology. ISSN 1351-5101. 16(12), s. 1255–1264. doi: 10.1111/j.1468-1331.2009.02811.x.
Harbo, Hanne Flinstad; Riccio, ME; Lorentzen, Åslaug Rudjord; Utsi, E; Myhr, Kjell Morten & Mellgren, Svein Ivar [Vis alle 10 forfattere av denne artikkelen] (2009). Norwegian Sami differs significantly from other Norwegians according to their HLA profile. Tissue Antigens. ISSN 0001-2815. doi: 10.1111/j.1399-0039.2009.01425.x.
Ramagopalan, SV; Link, Jenny; Byrnes, JK; Dyment, DA; Giovannoni, G & Hintzen, RQ [Vis alle 17 forfattere av denne artikkelen] (2009). HLA-DRB1 and month of birth in multiple sclerosis. Neurology. ISSN 0028-3878. 73(24), s. 2107–2111. doi: 10.1212/WNL.0b013e3181c679f3.
Pugliatti, M.; Harbo, HF; Harbo, H.F.; Holmøy, T.; Kampman, Margitta Theodora & Myhr, K.-M. [Vis alle 8 forfattere av denne artikkelen] (2008). Environmental risk factors in multiple sclerosis. Acta Neurologica Scandinavica. ISSN 0001-6314. 117, s. 34–40. Vis sammendrag
Objectives - Multiple sclerosis (MS)likely results form an interaction between genetic and exogenous factors. While genetics shapes the overall population MS susceptibility, observed epidemiological patterns strongly suggest a role for the environment in disease initiation and modulation. Results - Findings from studies on seasonality in MS patient`s birth, disease onset and exacerbations, as well as apparent temporal trends in incidence and gender ratio support an influential effect og viruses, metabolic and lifestyle factors on MS risk. Epstein-Barr virus, vitamin D status, and smoking are factors that may explain such epidemiological patterns. Conclusions - Further epidemiological investigations are encouraged and opportunities to use data from existing cohort studies as well as the design of new studies shold be pursued. In particular, the development of new large multicentre population-based case control studies which incorporate the study of the role of environment and genetics, including epigenetic mechanisms, in determining MS risk in proposed.
Lorentzen, Åslaug R; Smestad, Cathrine; Lie, Benedicte A; Lie, BA; Oturai, Annette & Oturai, AB [Vis alle 18 forfattere av denne artikkelen] (2008). The SH2D2A gene and susceptibility to multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 197, s. 152–158. doi: 10.1016/j.jneuroim.2008.04.037.
Smestad, C; Sandvik, L; Holmøy, Trygve; Harbo, Hanne Flinstad & Celius, Elisabeth Gulowsen (2008). Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway. Journal of Neurology. ISSN 0340-5354. 255. doi: 10.1007/s00415-007-0659-8.
Harbo, HF; Utsi, E; Lorentzen, Åslaug Rudjord; Lorentzen, AR; Kampman, Margitta Theodora & Celius, EG [Vis alle 10 forfattere av denne artikkelen] (2007). Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami. Tissue Antigens. ISSN 0001-2815. 69(4), s. 299–304. doi: 10.1111/j.1399-0039.2007.00803.x.
Hensiek, Anke E.; Seaman, Shaun Robert ; Barcellos, Lisa F.; Oturai, Annette; Eraksoi, M. & Cocco, Eleonora [Vis alle 27 forfattere av denne artikkelen] (2007). Familial effects on the clinical course of multiple sclerosis. Neurology. ISSN 0028-3878. 68(5), s. 376–383.
Datta, Pameli; Harbo, Hanne F; Ryder, Lars P.; Akesson, E; Åkesson, Elisabeth & Benedikz, John [Vis alle 17 forfattere av denne artikkelen] (2007). A follow-up study of Nordic multiple sclerosis candidate gene regions. Multiple Sclerosis. ISSN 1352-4585. 13(5), s. 584–589. doi: 10.1177/1352458506071790.
Smestad, C; Brynedal, B; Jonasdottir, G; Lorentzen, Åslaug Rudjord; Masterman, T & Akesson, E [Vis alle 12 forfattere av denne artikkelen] (2007). The impact of HLA-A and-DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. European Journal of Neurology. ISSN 1351-5101. 14, s. 835–840. doi: 10.1111/j.1468-1331.2007.01825.x.
Lundmark, F; Duvefelt, K; Iacobaeus, E; Kockum, I; Wallstrom, E & Khademi, M [Vis alle 14 forfattere av denne artikkelen] (2007). Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis. Nature Genetics. ISSN 1061-4036. 39, s. 1108–1113. doi: 10.1038/ng2106.
Knudsen, Gun Peggy Strømstad; Harbo, Hanne Flinstad; Smestad, C; Celius, EG; Akesson, E & Oturai, A [Vis alle 9 forfattere av denne artikkelen] (2007). X chromosome inactivation in females with multiple sclerosis. European Journal of Neurology. ISSN 1351-5101. 14, s. 1392–1396. doi: 10.1111/j.1468-1331.2007.01987.x.
Lundmark, F; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Saarela, J; Datta, Pameli & Oturai, Anette [Vis alle 10 forfattere av denne artikkelen] (2006). Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations. Journal of Neuroimmunology. ISSN 0165-5728. 180, s. 193–198.
Wiencke, Kristine; Boberg, Kirsten Muri; Donaldson, P; Harbo, Hanne Flinstad; Ling, V & Schrumpf, Erik [Vis alle 7 forfattere av denne artikkelen] (2006). No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 41.
Harbo, Hanne Flinstad; Ekstrom, PO; Lorentzen, Åslaug Rudjord; Gjerstad, Vibeke Sundvold; Celius, EG & Sawcer, Stephen [Vis alle 7 forfattere av denne artikkelen] (2006). Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 177, s. 40–45.
Lorentzen, Åslaug Rudjord; Celius, Elisabeth Gulowsen; Ekstrøm, Per Olaf; Wiencke, Kristine; Lie, Benedicte Alexandra & Myhr, KM [Vis alle 11 forfattere av denne artikkelen] (2005). Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients. Journal of Neuroimmunology. ISSN 0165-5728. 166.
Torkildsen, O; Torkildsen, Øivind Fredvik; Utsi, Egil; Harbo, Hanne F; Mellgren, Svein Ivar & Vedeler, Christian A. [Vis alle 7 forfattere av denne artikkelen] (2005). Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian population. Scandinavian Journal of Immunology. ISSN 0300-9475. 62(1), s. 71–74.
Torkildsen, O; Torkildsen, Øivind Fredvik; Utsi, Egil; Mellgren, Svein Ivar; Harbo, Hanne F & Vedeler, Christian A. [Vis alle 7 forfattere av denne artikkelen] (2005). Ethnic variation of Fc gamma receptor polymorphism in Sami and Norwegian populations. Immunology. ISSN 0019-2805. 115(3), s. 416–421.
Smerdel, Anna; Finholt, Camilla; Lilleby, Vibke; Gilboe, Inger-Margrethe; Harbo, Hanne Flinstad & Maslinski, S [Vis alle 9 forfattere av denne artikkelen] (2005). Systemic lupus erythematosus and the extended major histocompatibility complex—evidence for several predisposing loci. Rheumatology (Sveits). ISSN 0080-2727. 44, s. 1368–1373. doi: 10.1093/rheumatology/kei015.
Harbo, Hanne Flinstad; Lie, Benedicte Alexandra; Sawcer, Stephen; Celius, EG; Dai, Kezheng & Oturai, Anette [Vis alle 22 forfattere av denne artikkelen] (2004). Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens. ISSN 0001-2815. 63, s. 237–247. Vis sammendrag
In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in linkage disequilibrium with it may contribute to the HLA class II-associated genetic susceptibility to MS.
Harbo, HF; Lie, BA; Sawcer, S; Celius, EG; Dai, KZ & Oturai, A [Vis alle 22 forfattere av denne artikkelen] (2004). Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens. ISSN 0001-2815. 63(3), s. 237–247.
Oturai, AB; Ryder, LP; Fredrikson, S; Myhr, KM; Celius, EG & Harbo, HF [Vis alle 16 forfattere av denne artikkelen] (2004). Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs. Multiple Sclerosis. ISSN 1352-4585. 10, s. 5–8.
Harbo, Hanne Flinstad; Datta, P.*; Oturai, Anette; Ryder, Lars P.; Sawcer, Stephen & Setakis, E.* [Vis alle 19 forfattere av denne artikkelen] (2003). Two genome-wide linikage disequilirium screens in Scandinavian multiple sclerosis patients. Journal of Neuroimmunology. ISSN 0165-5728. 143(1-2), s. 101–106.
Åkesson, Eva; Caraddu, F; Marrosu, M.*; Massacesi, L.*; Hensieki, A & Harbo, Hanne Flinstad [Vis alle 10 forfattere av denne artikkelen] (2003). Fine mapping of a candidate region on chromosome 10 in 499 sib-pairs with multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 143(1-2), s. 31–8.
Myhr, Kjell Morten & Harbo, Hanne Flinstad (2003). Multippel sklerose en sykdom med kompleks genetikk. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 123(19), s. 2723–2726.
Myhr, Kjell-Morten & Harbo, HF (2003). Multippel sklerose - en sykdom med kompleks genetikk. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 123, s. 2723–2726.
Harbo, HF; Datta, P; Otturai, A; Ryder, LP; Sawcer, S & Setakis, E [Vis alle 18 forfattere av denne artikkelen] (2003). Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients. Journal of Neuroimmunology. ISSN 0165-5728. 143, s. 101–106.
Harbo, HF; Datta, P; Spurkland, Anne; Ryder, LP; Sawcer, S & Celius, EG [Vis alle 14 forfattere av denne artikkelen] (2002). A genome wide linkage disequilibrium screen in Scandinavian multiple sclerosis patients shows association to chromosome regions at 1 q (D1S1601) and 11q (D11S1986), The Islandic Medical Journal 2000. MANGLER.
Akesson, Eva; Oturai, Anette; Berg, Jens Petter; Fredrikson, Sten; Andersen, Oluf & Harbo, Hanne Flinstad [Vis alle 16 forfattere av denne artikkelen] (2002). A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes and Immunity. ISSN 1466-4879. 3, s. 279–285. Vis sammendrag
Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis
Akesson, E; Oturai, A; Berg, J; Fredrikson, S; Anderson, O & Harbo, HF [Vis alle 18 forfattere av denne artikkelen] (2002). A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes and Immunity. ISSN 1466-4879. 3, s. 279–285.

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Helseth, Eirik; Rootwelt, Terje & Harbo, Hanne Flinstad (2019). Nevrologi og nevrokirurgi. Fra barn til voksen, 7. utg. . Fagbokforlaget. ISBN 978-82-450-2473-9. 1000 s.
Helseth, Eirik; Rootwelt, Terje & Harbo, Hanne Flinstad (2019). Nevrologi og nevrokirurgi ; fra barn til voksen. Fagbokforlaget. ISBN 9788245024739. 582 s.

Se alle arbeider i Cristin

Nygaard, Gro Owren; Schikora-Rustad, Stine; Lie, Ingeborg Haugesag; Aase, Audun; Leiknes, Ingvild Jullum & König, Marton [Vis alle 15 forfattere av denne artikkelen] (2021). Humoral immune response to the influenza vaccine in multiple sclerosis patients treated with cladribine or rituximab.
König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Vis alle 22 forfattere av denne artikkelen] (2021). Humoral Immunity to SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis using High-Efficacy Disease Modifying Therapies.
Bos, Steffan Daniel; Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Vitelli, Valeria & Celius, Elisabeth Gulowsen [Vis alle 10 forfattere av denne artikkelen] (2019). Differential gene expression analysis of CD8+ T cells from multiple sclerosis patients and healthy controls .
Glover, Joel; Tysnes, Ole-Bjørn; Myhr, Kjell-Morten; Bråthen, Geir; Sandvig, Ioanna & Høyer, Helle [Vis alle 9 forfattere av denne artikkelen] (2019). Hvor står ALS-forskningen i Norge? VG : Verdens gang. ISSN 0805-5203.
Bos, Steffan Daniel; Brorson, Ina Skaara; Høgestøl, Einar August; Berge, Tone; Saez-Rodriguez, Julio & Uccelli, Antonio [Vis alle 9 forfattere av denne artikkelen] (2018). Multiple Sclerosis genetic burden score in a systems biology study of MS patients from four countries.
Berge, Tone; Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Harbo, Hanne Flinstad & Bos, Steffan Daniel [Vis alle 7 forfattere av denne artikkelen] (2018). Proteomic profiling of T cells from multiple sclerosis patients and healthy controls.
Cellerino, Maria; Pardini, Matteo; Ivaldi, Frederico; Vila, Gemma; Berge, Tone & Koduah, Priscilla [Vis alle 14 forfattere av denne artikkelen] (2018). Personalizing health care in Multiple Sclerosis using systems medicine tools: presentation of the cytomics data from the Sys4MS project.
Zubizarreta, Irati; de Rosbo, Nicole Kerlero; Rinas, Melanie; Høgestøl, Einar August; de Rodez Benavent, Sigrid Aune & Bos, Steffan Daniel [Vis alle 17 forfattere av denne artikkelen] (2018). The Sys4MS project: Personalizing health care in Multiple Sclerosis using systems medicine tools .
Brorson, Ina Skaara; Rhead, Brooke; Berge, Tone; Adams, Cameron; Quach, Hong & Sangurdekar, Dipen [Vis alle 18 forfattere av denne artikkelen] (2018). SLFN12 is differentially methylated in multiple sclerosis CD4+ and CD8+ T cells .
Cellerino, Maria; Pardini, Matteo; Campi, Cristina; Ivaldi, Frederico; Vila, Gemma & Berge, Tone [Vis alle 13 forfattere av denne artikkelen] (2018). Personalizing health care in Multiple Sclerosis using systems medicine tools: Presentation of the cytomics data .
Berge, Tone; Brorson, Ina Skaara; Høgestøl, Einar August; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Berven, Frode (2018). Proteomic profiling of CD4+ and CD8+ T cells from multiple sclerosis patients and healthy controls.
Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Berven, Frode [Vis alle 7 forfattere av denne artikkelen] (2018). Proteomic profiling of CD4+ T cells from MS patients show increased activity of T cell activation pathways (compared to healthy controls) .
Leikfoss, Ingvild Sørum; Bos, Steffan Daniel; Berg-Hansen, Pål; Berge, Tone; Beyer, Mona K. & Celius, Elisabeth Gulowsen [Vis alle 8 forfattere av denne artikkelen] (2018). The EU Horizon2020 Project MultipleMS: Improved Personalized Medicine for Multiple Sclerosis .
Berge, Tone; Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Bos, Steffan Daniel & Harbo, Hanne Flinstad [Vis alle 7 forfattere av denne artikkelen] (2018). Proteomic profiling of CD4+ and CD8+ T cells from multiple sclerosis patients and healthy controls.
Brorson, Ina Skaara; Rhead, Brooke; Berge, Tone; Lea, Rodney A.; Burnard, Sean & Scott, Rodney J. [Vis alle 10 forfattere av denne artikkelen] (2018). Differently methylated regions in multiple sclerosis CD4+ and CD8+ T cells .
Rhead, Brooke; Brorson, Ina Skaara; Berge, Tone; Adams, Cameron; Quach, Hong & Sangurdekar, Dipen [Vis alle 15 forfattere av denne artikkelen] (2018). Differential DNA methylation and expression of SLFN12 in multiple sclerosis patients’ CD4+ and CD8+ T cells.
Bajwa, Simranjit Kaur; Nilsen, Kristian Bernhard; Erichsen, Erik Aksel Spendrup; Berg-Hansen, Pål & Harbo, Hanne Flinstad (2018). En mann i 50-årene med svimmelhet, dobbeltsyn og gangvansker. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(3). doi: 10.4045/tidsskr.16.1109.
Bos, Steffan Daniel; Brorson, Ina Skaara; Barcellos, Lisa F; Berge, Tone & Harbo, Hanne Flinstad (2017). Gene expression profiling of CD4+ T cells from multiple sclerosis patients and healthy controls.
Brorson, Ina Skaara; Rhead, Brooke; Quach, Hong; Berg-Hansen, Pål; Berge, Tone & Harbo, Hanne Flinstad [Vis alle 8 forfattere av denne artikkelen] (2017). DNA methylation differences in CD4+ and CD8+ T cells of multiple sclerosis patients and healthy controls.
Mo, Ingrid; Eriksson, Anna; Brorson, Ina Skaara; Ledsaak, Marit; Harbo, Hanne Flinstad & Gabrielsen, Odd Stokke [Vis alle 7 forfattere av denne artikkelen] (2017). Identifying protein interaction partners for DEXI - encoded by the dexamethasone-induced gene, DEXI .
Fernanda, Kropf Correia; Brorson, Ina Skaara; Eriksson, Anna; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Berge, Tone (2017). Molecular characterization of TAGAP – a GTPase-activating protein encoded by a multiple sclerosis susceptibility gene.
Brorson, Ina Skaara; Eriksson, Anna; Baranzini, Sergio; Berge, Tone; Harbo, Hanne Flinstad & Bos, Steffan Daniel (2017). Gene expression in pathways enriched with MS associated risk loci.
Moen, Stine Marit; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Sowa, Piotr; Nygaard, Gro Owren & Beyer, Mona K. (2016). S.M. Moen og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(19), s. 1608–1608. doi: 10.4045/tidsskr.16.0826.
Moen, Stine Marit; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Sowa, Piotr; Nygaard, Gro Owren & Beyer, Mona K. (2016). S.M. Moen og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(20), s. 1702–1702. doi: 10.4045/tidsskr.16.0865.
Moen, Stine Marit; Harbo, Hanne Flinstad; Sowa, Piotr; Celius, Elisabeth Gulowsen; Nygaard, Gro Owren & Beyer, Mona K. (2016). MR-undersøkelser ved multippel sklerose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(16), s. 1373–1376. doi: 10.4045/tidsskr.15.1361.
Berg-Hansen, Pål; Moen, Stine Marit; Harbo, Hanne Flinstad & Celius, Elisabeth Gulowsen (2015). Comments on the review article 'Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades'. Acta Neurologica Scandinavica. ISSN 0001-6314. 132(5), s. 364–367. doi: 10.1111/ane.12489.
Gustavsen, Marte Wendel; Celius, Elisabeth Gulowsen; Moen, Stine Marit; Bjølgerud, Anja; Berg-Hansen, Pål & Nygaard, Gro Owren [Vis alle 9 forfattere av denne artikkelen] (2015). No association between multiple sclerosis and periodontitis after adjusting for smoking habits. European Journal of Neurology. ISSN 1351-5101. 22(3), s. 588–590. doi: 10.1111/ene.12520.
Nygaard, Gro Owren; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen & Landro, N. I. (2013). Does the Brief International Cognitive Assessment for MS (BICAMS) catch the cognitive problems of a sample of well-educated recently diagnosed MS patients in Oslo? Multiple Sclerosis. ISSN 1352-4585. 19(7), s. 970–971.
Leikfoss, Ingvild S; Mero, Inger-Lise; Dahle, Maria Krudtaa; Lie, Benedicte Alexandra; Harbo, Hanne Flinstad & Spurkland, Anne [Vis alle 7 forfattere av denne artikkelen] (2012). Multiple Sclerosis Associated Single Nucleotide Polymorphisms in CLEC16A Correlate with Reduced SOCS1 and DEXI Expression in Thymic Samples. Scandinavian Journal of Immunology. ISSN 0300-9475. 76(2), s. 196–196.
Leikfoss, Ingvild Sørum; Berge, Tone; Harbo, Hanne Flinstad & Spurkland, Anne (2012). Multiple sclerosis-associated single nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in thymic tissue.
Berge, Tone; Leikfoss, Ingvild Sørum; Spurkland, Anne; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2012). Multiple sclerosis-associated single nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in thymic tissue.
Link, J.; Kockum, I.; Lorentzen, Åslaug Rudjord; Lie, Benedicte Alexandra; Celius, Elisabeth Gulowsen & Schaffer, M. [Vis alle 9 forfattere av denne artikkelen] (2011). Investigation of HLA genes in multiple sclerosis in Scandinavia. Journal of Neurology. ISSN 0340-5354. 258, s. 196–196.
Maniaol, Angelina; Boldingh, Marion Ingeborg; Brunborg, Cathrine; Harbo, Hanne Flinstad & Tallaksen, Chantal (2011). A POPULATION-BASED DESCRIPTIVE EPIDEMIOLOGIC STUDY OF MYASTHENIA GRAVIS IN NORWAY. European Journal of Neurology. ISSN 1351-5101. 18(S2), s. 276–276.
Sørum, Ingvild; Mero, Inger-Lise; Gustavsen, Marte Wendel; Muggerud, Aslaug; Sæther, Hanne Skarpodde & Lie, Benedicte Alexandra [Vis alle 9 forfattere av denne artikkelen] (2011). Molecular Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 377–377.
Holmøy, Trygve; Harbo, Hanne Flinstad & Celius, Elisabeth Gulowsen (2010). Behandling av multippel sklerose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(9).
Booth, DR; Heard, RN; Stewart, GJ; Cox, M; Scott, RJ & Lechner-Scott, J [Vis alle 42 forfattere av denne artikkelen] (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics. ISSN 1061-4036. 42(6), s. 469–470.
Brorson, Ina Skaara; Rhead, Brooke; Berge, Tone; Adams, Cameron; Quach, Hong & Sangurdekar, Dipen [Vis alle 18 forfattere av denne artikkelen] (2010). SLFN12 is differentially methylated in multiple sclerosis CD4+ and CD8+ T cells .
Lorentzen, Åslaug Rudjord; Melum, Espen; Buchert, Eva; SMESTAD, CATHRINE; Mero, Inger-Lise & Aarseth, Jan Harald [Vis alle 12 forfattere av denne artikkelen] (2010). Trend of association to the Glypican 5 gene region to multiple sclerosis. European Journal of Neurology. ISSN 1351-5101. 17, s. 221–221.
Lorentzen, AR; Karlsen, Tom Hemming; Olsson, M; SMESTAD, CATHRINE; Mero, Inger-Lise & Woldseth, B [Vis alle 13 forfattere av denne artikkelen] (2009). Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. European Journal of Neurology. ISSN 1351-5101. 16, s. 19–19.
Mero, Inger-Lise; Lorentzen, AR; Ban, Maria; SMESTAD, CATHRINE; Celius, Elisabeth Gulowsen & Aarseth, JH [Vis alle 20 forfattere av denne artikkelen] (2009). The TYK2 gene is associated with susceptibility to multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 15(9), s. S186–S186.
Sawcer, Stephen; Booth, David; Heard, Robert; Stewart, Graeme; An, Goris & Dobosi, Rita [Vis alle 63 forfattere av denne artikkelen] (2008). Refining genetic associations in multiple sclerosis. Lancet Neurology. ISSN 1474-4422. 7(7), s. 567–569. doi: 10.1016/S1474-4422%2808%2970122-4.
Harbo, Hanne Flinstad (2008). A non-synonymous SNP based genome-wide association study in multiple sclerosis identifies the nonreceptor tyrosine-protein kinase gene (TYK2) on chromosome 19. European Journal of Neurology. ISSN 1351-5101. 15, s. 27–27.
Lorentzen, Åslaug Rudjord; Ban, Maria; Booth, David; Heard, Robert; Stewart, Graeme & Goris, An [Vis alle 33 forfattere av denne artikkelen] (2008). The expanding genetic overlap between multiple sclerosis and type 1 diabetes. Vis sammendrag
A familial clustering of autoimmune disease is well recognised and suggests that some susceptibility genes may predispose to autoimmunity in general whereas other genes lead to specific disease. On the basis of this hypothesis it may be expected that variants of established relevance in one autoimmune disease might also be relevant in other related conditions. To investigate this we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis dataset consisting of 2,369 trio families, 5,737 cases and 10,296 unrelated controls. Samples were recruited from across six countries: Australia, Belgium, Norway, Sweden, United Kingdom (UK) and the United States of America (USA) within the IMSGC. Two of these seven SNPs emerged as also being associated with multiple sclerosis; rs12708716 from the C-type lectin domain family 16, member A (CLEC16A) gene (p=1.6x10-15) and rs763361 from the CD226 gene (p=5.4x10-8). In each case the allele associated with increased risk for multiple sclerosis was identical to that showing evidence for association with T1D. These findings thereby confirm two additional multiple sclerosis susceptibility genes and lend support to the notion of commonality amongst autoimmune susceptibility genes.
Lorentzen, Åslaug Rudjord; Karlsen, Tom Hemming; Olsson, Marita; Smestad, Cathrine; Mero, Inger-Lise & Woldseth, Bente [Vis alle 13 forfattere av denne artikkelen] (2008). Protection against multiple sclerosis conferred by carriage of the inhibitory killer immunoglobulin-like receptors (KIRs) ligand HLA-Bw4. Vis sammendrag
Background: Combinations of killer immunoglobulin-like receptors (KIRs) and HLA class I ligands that reduce natural killer (NK) cells inhibition may increase the risk of autoimmune diseases. Multiple sclerosis (MS) is affecting the central nervous system and is presumed to be an autoimmune disease. There are significant genetic associations to genes in the HLA class II region (DRB1*1501-haplotype),but associations to genes in the HLA class I region have also been reported (for instance A2, A3 and Cw*05). We investigated whether there might be associations to given KIRs and/or their HLA class I ligands . Materials and methods: 631 Norwegian MS patients and 555 Norwegian controls were typed for the presence or absence of genes encoding inhibiting KIRs (KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL5, KIR3DL1, KIR3DL2 and KIR3DL3) and activating KIRs (KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5 and KIR2DL4) using sequence specific primers. HLA-A, -B, -C and –DRB1 typing was performed by direct sequencing or sequence specific primers. Results: We found no significant differences in gene carrier frequencies of inhibitory and activating KIRs in MS patients as compared to controls when p-values were adjusted for number of KIR genes investigated. However, the frequency of the HLA-Bw4 specificity was significantly reduced in MS patients as compared to controls (41.5% vs. 55.1%, p=4.9*10-6), even in individuals who did not carry any of the known HLA class II risk alleles (DRB1*1501,DRB1*03 and DRB1*01, p=0.002). No HLA class II independent associations were observed to genes at the HLA-C or HLA -A loci. Conclusion: The presence of the HLA-Bw4 specificity seems to protect against MS in an HLA class II independent manner. Ongoing analyses aim to characterize possible interaction effects between HLA-Bw4 and KIR3DL1 and KIR3DS1, as well as between HLA-C1 and C2 groups and their corresponding receptors.
SMESTAD, CATHRINE; Brynedal, B; Jonasdottir, G; Lorentzen, AR; Masterman, T. & Akesson, E [Vis alle 12 forfattere av denne artikkelen] (2007). The impact of HLA-A and HLA-DRB1 alleles on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. European Journal of Neurology. ISSN 1351-5101. 14, s. 22–22.
Harbo, Hanne F; Mørk, Sverre; Vedeler, Christian A. & Myhr, Kjell-Morten (2007). Biobank for multippel sklerose etablert. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 127(17).
Lorentzen, AR; SMESTAD, CATHRINE; Ekstrøm, Per Olaf; Oturai, Annette Bang; Åkesson, Eva & Saarela, Janna [Vis alle 13 forfattere av denne artikkelen] (2006). The role of SH2D2A gene polymorphisms in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 12(Suppl 1), s. S72–S72.
Harbo, Hanne Flinstad; Utsi, E; Lorentzen, Åslaug Rudjord; T Kampman, M; Celius, EG & Myhr, KM [Vis alle 7 forfattere av denne artikkelen] (2006). Low prevalence of multiple sclerosis in a Sami population is related to low frequency of the disease-associated HLA DR15-DQ6 haplotype. Tissue Antigens. ISSN 0001-2815. 67, s. 523–523.
Harbo, HF; Utsi, Egil; Kampman, Margitta Theodora; Celius, EG; Myhr, KM & Lie, BA [Vis alle 8 forfattere av denne artikkelen] (2006). Low prevalence of multiple sclerosis and the HLA CR15-DQ6 halotype in Sami. Multiple Sclerosis. ISSN 1352-4585. 12, s. 71–71.
Wiencke, Kristine; Karlsen, TH; Boberg, Kirsten Muri; Harbo, Hanne Flinstad; Lie, Benedicte Alexandra & Thorsby, Erik [Vis alle 8 forfattere av denne artikkelen] (2005). Association to the HLA-DR6 haplotype in PSC: Additional effects in the HLA class I/extended class I region. Journal of Hepatology. ISSN 0168-8278. 42.
Lorentzen, Åslaug Rudjord; Celius, EG; Ekstrom, P; Wiencke, Kristine; Lie, Benedicte Alexandra & Myhr, KM [Vis alle 11 forfattere av denne artikkelen] (2005). The CD28/CTLA4/ICOS gene region does not show assosiation in Norwegian multiple sclerosis patients. Genes and Immunity. ISSN 1466-4879. 6.
Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Lie, Benedicte Alexandra; Sawcer, Stephen; Dai, Ke-Zheng & Oturai, Anette [Vis alle 21 forfattere av denne artikkelen] (2003). Genes in the HLA class I region may modify the genetic associated susceptiblility to multiple sclerosis.
Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Lie, Benedicte Alexandra; Sawcer, Stephen; Dai, Ke-Zheng & Oturai, Anette [Vis alle 21 forfattere av denne artikkelen] (2003). Genes in the HLA class I region may modify the genetic associated susceptiblility to multiple sclerosis.
Harbo, HF; Datta, P; Spurkland, Anne; Ryder, LP; Sawcer, S & Celius, EG [Vis alle 16 forfattere av denne artikkelen] (2002). A genome-wide linkage disequilibrium screen in Scandinavian multiple sclerosis patients shows association to chromosome regions at 1q (D1S1601) and 11q (D11S1986).
Datta, P; Harbo, HF; Spurkland, Anne; Ryder, LP; Sawcer, S & Akesson, E [Vis alle 16 forfattere av denne artikkelen] (2002). A Scandinavian genome-wide linkage disequilibrium screen in multiple sclerosis patients indicates association to 1q (D1S1601) and 11q (D11S1986).
Berge, Tone; Gustavsen, Marte Wendel & Harbo, Hanne Flinstad (2015). Genetic, clinical and environmental aspects of multiple sclerosis. UiO.
Harbo, Hanne Flinstad (2003). Genome-wide screen and candidate gene search in multiple sclerosis. Universitetet i Oslo.

Se alle arbeider i Cristin

Publisert 13. apr. 2011 11:39 - Sist endret 11. des. 2020 14:20

Prosjekter

MultipleMS

Forskergrupper

Multippel Sklerose (MS)