Jan Terje Andersen

Bilde av Jan Terje Andersen
English version of this page
Telefon +47 22857275
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 1057 Blindern 0316 Oslo

About The Laboratory of Adaptive Immunity and Homeostasis

The research group is studying the cellular processes and molecular interplay underlying the functions of the two most abundant proteins in blood, albumin and IgG. Such knowledge offers opportunities for development of novel concepts that will secure improved half-life and biodistribution of IgG and albumin based therapeutics. The laboratory has an eye on translational research, is highly innovative and is the research group at the University of Oslo and Oslo University Hospital with most registered innovations at Inven2. The laboratory is collaborating extensively with biotech and pharmaceutical companies. The head of the laboratory, Jan Terje Andersen, has obtained the Fridtjof Nansen Prize for Early Career Achievements, Oslo University Hospital Early Career Award and is a member of The Young Academy of Norway.  

Projects

A) Studies of the interactions of antibodies with their Fc receptors, with a particular focus on the neonatal Fc receptor (FcRn) and its relationship with IgG and albumin. In addition, we are investigating how FcRn acts as a transporter in different cell types of the body. The studies will unravel the basic structural and cellular mechanisms that govern the functions of FcRn. Such knowledge offers opportunities for development of novel drug concepts that will secure improved half-life and biodistribution.

B) Studies of the mechanisms of infections at different body sites and how humoral immunity fights and restricts infection and virus replication. In particular, we are studying how antibodies contribute to protection against infectious diseases, and how FcRn and tripartite motif containing 21 (TRIM21) take part in cellular protection. Such knowledge can be utilized to develop novel antibody technologies tailored to combat infectious diseases.

 

For more information, please visit:

www.ous-research.no/andersen/

Facebook profile 

Linkedin profile

Twitter: @Andersen JT

 

The Young Academy of Norway:

http://akademietforyngreforskere.no/medlem/jan-terje-andersen/

Publikasjoner

  • Zakrzewicz, Anna; Würth, Celina; Beckert, Benedikt; Feldhoff, Simon; Vanderheyden, Katrien & Foss, Stian [Vis alle 11 forfattere av denne artikkelen] (2022). Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells. ISSN 2073-4409. 11(6), s. 1–23. doi: 10.3390/cells11060942.
  • Akbar, Rahmad; Robert, Philippe Paul Auguste; Weber, Cédric R.; Widrich, Michael; Frank, Robert & Pavlovic, Milena [Vis alle 19 forfattere av denne artikkelen] (2022). In silico proof of principle of machine learning-based antibody design at unconstrained scale. mAbs. ISSN 1942-0862. 14:e2031482(1), s. 1–18. doi: 10.1080/19420862.2022.2031482.
  • Grevys, Algirdas; Frick, Rahel; Mester, Simone; Flem-Karlsen, Karine; Nilsen, Jeannette & Foss, Stian [Vis alle 13 forfattere av denne artikkelen] (2022). Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. iScience. ISSN 2589-0042. 25(2). doi: 10.1016/j.isci.2022.103746.
  • Akbar, Rahmad; Bashour, Habib; Rawat, Puneet; Robert, Philippe Paul Auguste; Smorodina, Eva & Cotet, Tudor-Stefan [Vis alle 15 forfattere av denne artikkelen] (2022). Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies. mAbs. ISSN 1942-0862. 14(1). doi: 10.1080/19420862.2021.2008790.
  • Sivertsen, Magne S.; Lode, Heidrun Elisabeth; Tollefsrud Gjølberg, Torleif; Petrovski, Goran; Andersen, Jan Terje & Jørstad, Øystein Kalsnes [Vis alle 7 forfattere av denne artikkelen] (2021). Cluster of symptomatic silicone oil droplets following intravitreal injections: A 1-year observational study. BMJ Open Ophthalmology. ISSN 2397-3269. 6:e000764(1), s. 1–5. doi: 10.1136/bmjophth-2021-000764. Fulltekst i vitenarkiv
  • Azevedo, Cláudia; Pinto, Soraia; Benjakul, Sopisa; Nilsen, Jeannette; Santos, Helder A. & Traverso, Giovanni [Vis alle 8 forfattere av denne artikkelen] (2021). Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery. Advanced Drug Delivery Reviews. ISSN 0169-409X. 175. doi: 10.1016/j.addr.2021.04.016. Fulltekst i vitenarkiv
  • Christopoulos, Panagiotis; Gjølberg, Torleif Tollefsrud; Krüger, Stig; Haraldsen, Guttorm; Andersen, Jan Terje & Sundlisæter, Eirik (2021). Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases. Frontiers in Immunology. ISSN 1664-3224. 12:668207, s. 1–22. doi: 10.3389/fimmu.2021.668207. Fulltekst i vitenarkiv
  • Azevedo, Cláudia; Andersen, Jan Terje; Traverso, Giovanni & Sarmento, Bruno (2021). The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 162, s. 99–104. doi: 10.1016/j.ejpb.2021.03.009.
  • König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Vis alle 22 forfattere av denne artikkelen] (2021). Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. doi: 10.1136/jnnp-2021-327612. Fulltekst i vitenarkiv
  • Tunheim, Gro; Rø, Gunnar Øyvind Isaksson; Tran, Trung; Kran, Anne-Marte Bakken; Andersen, Jan Terje & Vaage, Eline Benno [Vis alle 10 forfattere av denne artikkelen] (2021). Trends in seroprevalence of SARS-CoV-2 and infection fatality rate in the Norwegian population through the first year of the COVID-19 pandemic. Influenza and Other Respiratory Viruses. ISSN 1750-2640. 16(2), s. 204–212. doi: 10.1111/irv.12932. Fulltekst i vitenarkiv
  • Merten, Hannes; Brandl, Fabian; Zimmermann, Martina; Schaefer, Jonas V.; Irpinio, Linda & Sand, Kine M.K. [Vis alle 10 forfattere av denne artikkelen] (2021). Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 167, s. 104–113. doi: 10.1016/j.ejpb.2021.07.011. Fulltekst i vitenarkiv
  • Mester, Simone; Evers, Mitchell; Meyer, Saskia; Nilsen, Jeannette; Greiff, Victor & Sandlie, Inger [Vis alle 8 forfattere av denne artikkelen] (2021). Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo. mAbs. ISSN 1942-0862. 13:1893888(1), s. 1–14. doi: 10.1080/19420862.2021.1893888. Fulltekst i vitenarkiv
  • Mandrup, Ole A.; Ong, Sui Ching; Lykkemark, Simon; Dinesen, Anders; Rudnik-Jansen, Imke & Dagnæs-Hansen, Niels Frederik [Vis alle 9 forfattere av denne artikkelen] (2021). Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity. Communications Biology. ISSN 2399-3642. 4:310(1), s. 1–11. doi: 10.1038/s42003-021-01790-2. Fulltekst i vitenarkiv
  • Lombardi, Silvia; Hovden Aaen, Kristin; Nilsen, Jeannette; Ferrarese, Mattia; Tollefsrud Gjølberg, Torleif & Bernardi, Francesco [Vis alle 9 forfattere av denne artikkelen] (2021). Fusion of engineered albumin with factor IX Padua extends half-life and improves coagulant activity. British Journal of Haematology. ISSN 0007-1048. 194(2), s. 453–462. doi: 10.1111/bjh.17559. Fulltekst i vitenarkiv
  • Høydahl, Lene; Frigstad, Terje; Rasmussen, Ingunn B; Øynebråten, Inger; Schjetne, Karoline W & Andersen, Jan Terje [Vis alle 10 forfattere av denne artikkelen] (2021). Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses. Vaccine. ISSN 0264-410X. 39(11), s. 1583–1592. doi: 10.1016/j.vaccine.2021.02.012. Fulltekst i vitenarkiv
  • Caddy, Sarah L.; Vaysburd, Marina; Papa, Guido; Wing, Mark; O'Connell, Kevin & Stoycheva, Diana [Vis alle 10 forfattere av denne artikkelen] (2020). Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity. EMBO Journal. ISSN 0261-4189. 40:e106228(5), s. 1–9. doi: 10.15252/embj.2020106228. Fulltekst i vitenarkiv
  • Schrottmaier, Waltraud C.; Salzmann, Manuel; Badrnya, Sigrun; Mussbacher, Marion; Kral-Pointer, Julia B. & Morava, Susanne [Vis alle 17 forfattere av denne artikkelen] (2020). Platelets mediate serological memory to neutralize viruses in vitro and in vivo. Blood Advances. ISSN 2473-9529. 4(16), s. 3971–3976. doi: 10.1182/bloodadvances.2020001786. Fulltekst i vitenarkiv
  • Hovden Aaen, Kristin; Anthi, Aina Karen; Sandlie, Inger; Nilsen, Jeannette; Mester, Simone & Andersen, Jan Terje (2020). The neonatal Fc receptor in mucosal immune regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. doi: 10.1111/sji.13017.
  • Nilsen, Jeannette; Trabjerg, Esben; Grevys, Algirdas; Azevedo, Claudia; Brennan, Stephen O. & Stensland, Maria [Vis alle 14 forfattere av denne artikkelen] (2020). An intact C-terminal end of albumin is required for its long half-life in humans. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-0903-7. Fulltekst i vitenarkiv
  • Hubbard, Jonathan J.; Pyzik, Michal; Rath, Timo; Kozicky, Lisa K.; Sand, Kine Marita Knudsen & Gandhi, Amit K. [Vis alle 17 forfattere av denne artikkelen] (2020). FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 217(10). doi: 10.1084/jem.20200359.
  • Caddy, Sarah L.; Vaysburd, Marina; Wing, Mark; Foss, Stian; Andersen, Jan Terje & O'Connell, Kevin [Vis alle 11 forfattere av denne artikkelen] (2020). Intracellular neutralisation of rotavirus by VP6-specific IgG. PLoS Pathogens. ISSN 1553-7366. 16:e1008732(8), s. 1–18. doi: 10.1371/journal.ppat.1008732. Fulltekst i vitenarkiv
  • Azevedo, Claudia; Nilsen, Jeanette; Grevys, Algirdas; Nunes, Rute; Andersen, Jan Terje & Sarmento, Bruno (2020). Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin . Journal of Controlled Release. ISSN 0168-3659. doi: 10.1016/j.jconrel.2020.08.005.
  • Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne & Holten, Aleksander Rygh [Vis alle 32 forfattere av denne artikkelen] (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients . Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(40), s. 25018–25025. doi: 10.1073/pnas.2010540117. Fulltekst i vitenarkiv
  • Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif & Lode, Heidrun Elisabeth [Vis alle 24 forfattere av denne artikkelen] (2020). An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. Science Translational Medicine. ISSN 1946-6234. 12(565), s. 1–13. doi: 10.1126/scitranslmed.abb0580. Fulltekst i vitenarkiv
  • Lau, Corinna; McAdam, Martin Berner; Bergseth, Grete; Grevys, Algirdas; Bruun, Jack-Ansgar & Ludviksen, Judith K [Vis alle 11 forfattere av denne artikkelen] (2019). NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies. mAbs. ISSN 1942-0862. 12:e1686319(1), s. 1–13. doi: 10.1080/19420862.2019.1686319. Fulltekst i vitenarkiv
  • Lode, Heidrun Elisabeth; Gjølberg, Torleif Tollefsrud ; Foss, Stian; Sivertsen, Magne S.; Brustugun, Jørgen & Andersson, Yvonne [Vis alle 9 forfattere av denne artikkelen] (2019). A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes. Scientific Reports. ISSN 2045-2322. 9:18021(1), s. 1–10. doi: 10.1038/s41598-019-54226-7. Fulltekst i vitenarkiv
  • Blumberg, Laurence J.; Humphries, John E.; Jones, Susan Dana; Pearce, L. Bruce; Holgate, Robert G.E. & Hearn, Arron R. [Vis alle 23 forfattere av denne artikkelen] (2019). Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. Science Advances. ISSN 2375-2548. 5:eaax9586(12), s. 1–13. doi: 10.1126/sciadv.aax9586. Fulltekst i vitenarkiv
  • Foss, Stian; Bottermann, Maria; Jonsson, Alexandra; Sandlie, Inger; James, Leo C. & Andersen, Jan Terje (2019). TRIM21-From intracellular immunity to therapy. Frontiers in Immunology. ISSN 1664-3224. 10:2049, s. 1–14. doi: 10.3389/fimmu.2019.02049. Fulltekst i vitenarkiv
  • Maaland, Astri Fjelde; Heyerdahl, Helen; O'Shea, Adam; Eiriksdóttir, Bergthora; Pascal, Veronique & Andersen, Jan Terje [Vis alle 8 forfattere av denne artikkelen] (2019). Targeting B-cell malignancies with the beta-emitting anti-CD37 radioimmunoconjugate 177Lu-NNV003. European Journal of Nuclear Medicine and Molecular Imaging. ISSN 1619-7070. 46(11), s. 2311–2321. doi: 10.1007/s00259-019-04417-1. Fulltekst i vitenarkiv
  • Labzin, LI; Bottermann, M; Rodriguez-Silvestre, P; Foss, Stian; Andersen, Jan Terje & Vaysburd, M [Vis alle 8 forfattere av denne artikkelen] (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal. ISSN 0261-4189. doi: 10.15252/embj.2018101365. Fulltekst i vitenarkiv
  • Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M. & Vaysburd, Marina [Vis alle 16 forfattere av denne artikkelen] (2019). Complement C4 prevents viral infection through capsid inactivation. Cell Host and Microbe. ISSN 1931-3128. 25(4), s. 617–629. doi: 10.1016/j.chom.2019.02.016. Fulltekst i vitenarkiv
  • Pyzik, Michal; Sand, Kine Marita Knudsen; Hubbard, Jonathan J.; Andersen, Jan Terje; Sandlie, Inger & Blumberg, Richard S. (2019). The neonatal Fc Receptor (FcRn): A misnomer? Frontiers in Immunology. ISSN 1664-3224. 10:1540(JULY), s. 1–24. doi: 10.3389/fimmu.2019.01540. Fulltekst i vitenarkiv
  • Shaw, Alan; Hoffecker, Ian T.; Smyrlaki, Ioanna; Rosa, João; Grevys, Algirdas & Bryant-Bratlie, Diane Lynn [Vis alle 10 forfattere av denne artikkelen] (2019). Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nature Nanotechnology. ISSN 1748-3387. 14(2), s. 184–190. doi: 10.1038/s41565-018-0336-3.
  • Nilsen, Jeannette; Bern, Malin C.; Sand, Kine Marita Knudsen; Grevys, Algirdas; Dalhus, Bjørn & Sandlie, Inger [Vis alle 7 forfattere av denne artikkelen] (2018). Human and mouse albumin bind their respective neonatal Fc receptors differently. Scientific Reports. ISSN 2045-2322. 8:14648, s. 1–12. doi: 10.1038/s41598-018-32817-0. Fulltekst i vitenarkiv
  • Bottermann, Maria; Foss, Stian; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James & O’Connell, Kevin [Vis alle 16 forfattere av denne artikkelen] (2018). TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(41), s. 10440–10445. doi: 10.1073/pnas.1806314115. Fulltekst i vitenarkiv
  • Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger & Bern, Malin C. [Vis alle 15 forfattere av denne artikkelen] (2018). A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nature Communications. ISSN 2041-1723. 9. doi: 10.1038/s41467-018-03061-x. Fulltekst i vitenarkiv
  • Sivertsen, Magne S.; Jørstad, Øystein Kalsnes; Grevys, Algirdas; Foss, Stian; Moe, Morten Carsten & Andersen, Jan Terje (2018). Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-20525-8. Fulltekst i vitenarkiv
  • Stapleton, Nigel M.; Armstrong-Fisher, Sylvia S.; Andersen, Jan Terje; van der Schoot, C. Ellen; Porter, Charlene & Page, Kenneth R. [Vis alle 12 forfattere av denne artikkelen] (2018). Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport. Molecular Immunology. ISSN 0161-5890. 95, s. 1–9. doi: 10.1016/j.molimm.2018.01.006. Fulltekst i vitenarkiv
  • Nilsen, Jeannette; Sandlie, Inger; Roopenian, Derry C. & Andersen, Jan Terje (2018). Animal models for evaluation of albumin-based therapeutics. Current Opinion in Chemical Engineering. ISSN 2211-3398. 19, s. 68–76. doi: 10.1016/j.coche.2017.11.007. Fulltekst i vitenarkiv
  • Pyzik, Michal; Rath, Timo; Kuo, Timothy T.; Win, Sanda; Baker, Kristi & Hubbard, Jonathan J. [Vis alle 24 forfattere av denne artikkelen] (2017). Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 114(14), s. E2862–E2871. doi: 10.1073/pnas.1618291114. Fulltekst i vitenarkiv
  • Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E.; Foss, Stian; Sandlie, Inger & Andersen, Jan Terje [Vis alle 7 forfattere av denne artikkelen] (2017). Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports. ISSN 2045-2322. doi: 10.1038/srep45418. Fulltekst i vitenarkiv
  • Cardoso, Ines Do Rosario; Østerlund, Eva Christina; Stamnæs, Jorunn; Iversen, Rasmus; Andersen, Jan Terje & Jørgensen, Thomas J D [Vis alle 7 forfattere av denne artikkelen] (2017). Dissecting the interaction between transglutaminase 2 and fibronectin. Amino Acids. ISSN 0939-4451. 49(3), s. 489–500. doi: 10.1007/s00726-016-2296-y. Fulltekst i vitenarkiv
  • Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E; Foss, Stian; Sandlie, Inger & Andersen, Jan Terje [Vis alle 7 forfattere av denne artikkelen] (2016). Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep37457. Fulltekst i vitenarkiv
  • Foss, Stian; Watkinson, Ruth E; Grevys, Algirdas; Mc, Adam Martin Berner; Bern, Malin C. & Høydahl, Lene Støkken [Vis alle 11 forfattere av denne artikkelen] (2016). TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity. Journal of Immunology. ISSN 0022-1767. 196(8), s. 3452–3459. doi: 10.4049/jimmunol.1502601. Fulltekst i vitenarkiv
  • Foss, Stian; Grevys, Algirdas; Sand, Kine Marita Knudsen; Bern, Malin C.; Blundell, Pat & Michaelsen, Terje Einar [Vis alle 9 forfattere av denne artikkelen] (2016). Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization. Journal of Controlled Release. ISSN 0168-3659. 223, s. 42–52. doi: 10.1016/j.jconrel.2015.12.033. Fulltekst i vitenarkiv
  • Foss, Stian; Watkinson, Ruth; Sandlie, Inger; James, Leo C. & Andersen, Jan Terje (2015). TRIM21: A cytosolic Fc receptor with broad antibody isotype specificity. Immunological Reviews. ISSN 0105-2896. 268(1), s. 328–339. doi: 10.1111/imr.12363. Fulltekst i vitenarkiv
  • Xi, Chien; Hnida, Kathrin; Graewert, Melissa Ann; Andersen, Jan Terje; Iversen, Rasmus & Tuukkanen, Anne [Vis alle 8 forfattere av denne artikkelen] (2015). Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Journal of Biological Chemistry. ISSN 0021-9258. 290(35), s. 21365–21375. doi: 10.1074/jbc.M115.669895.
  • Cardoso, Ines Do Rosario; Stamnæs, Jorunn; Andersen, Jan Terje; Melino, Gerry; Iversen, Rasmus & Sollid, Ludvig Magne (2015). Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies. The FEBS Journal. ISSN 1742-464X. 282(11), s. 2063–2075. doi: 10.1111/febs.13276.
  • Almåsbak, Hilde Kjersti; Walseng, Even; Kristian, Alexandr; Myhre, Marit Renee; Suso, Else Marit Inderberg & Munthe, Ludvig Andre [Vis alle 11 forfattere av denne artikkelen] (2015). Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model. Gene Therapy. ISSN 0969-7128. 22(5), s. 391–403. doi: 10.1038/gt.2015.4.
  • Grevys, Algirdas; Bern, Malin C.; Foss, Stian; Bratlie, Diane Lynn Bryant; Moen, Anders & Gunnarsen, Kristin Støen [Vis alle 10 forfattere av denne artikkelen] (2015). Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions. Journal of Immunology. ISSN 0022-1767. 194(11), s. 5497–5508. doi: 10.4049/jimmunol.1401218. Fulltekst i vitenarkiv
  • Daniel M, Czajkowsky; Andersen, Jan Terje; Fuchs, Anja; Wilson, Timothy J; Mekhaiel, David & Colonna, Marco [Vis alle 17 forfattere av denne artikkelen] (2015). Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications. Scientific Reports. ISSN 2045-2322. 5, s. 1–11. doi: 10.1038/srep09526. Fulltekst i vitenarkiv
  • Bern, Malin C.; Sand, Kine Marita Knudsen; Nilsen, Jeannette; Sandlie, Inger & Andersen, Jan Terje (2015). The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery. Journal of Controlled Release. ISSN 0168-3659. 211, s. 144–162. doi: 10.1016/j.jconrel.2015.06.006.
  • Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Noordzij, Hanna Theodora; Sandlie, Inger & Andersen, Jan Terje (2015). Unraveling the interaction between FcRn and albumin: Opportunities for design of albumin-based therapeutics. Frontiers in Immunology. ISSN 1664-3224. 5:682. doi: 10.3389/fimmu.2014.00682. Fulltekst i vitenarkiv
  • Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias & Holt, jan [Vis alle 14 forfattere av denne artikkelen] (2015). Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. Immunobiology. ISSN 0171-2985. 220(4), s. 452–459. doi: 10.1016/j.imbio.2014.11.003. Fulltekst i vitenarkiv
  • Andersen, Jan Terje; Hjelstuen, Ole Kristian & Sandlie, Inger (2014). From Basic Research to Innovation, Medical Technology - Meeting Tomorrow's Health Care Challenges. Novus Forlag. ISSN 978-82-7099-791-6. s. 39–50.
  • Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Dalhus, Bjørn; Gunnarsen, Kristin Støen & Cameron, Jason [Vis alle 10 forfattere av denne artikkelen] (2014). Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc Receptor (FcRn). Journal of Biological Chemistry. ISSN 0021-9258. 289(50), s. 34583–34594. doi: 10.1074/jbc.M114.587675. Fulltekst i vitenarkiv
  • Einarsdottir, Helga K.; Stapleton, Nigel M.; Scherjon, Sicco; Andersen, Jan Terje; Rispens, Theo & van der Schoot, C. Ellen [Vis alle 7 forfattere av denne artikkelen] (2014). On the perplexingly low rate of transport of IgG2 across the human placenta. PLOS ONE. ISSN 1932-6203. 9(9). doi: 10.1371/journal.pone.0108319.
  • Andersen, Jan Terje; Dalhus, Bjørn; Viuff, Dorthe; Ravn, Birgitte Thue; Gunnarsen, Kristin Støen & Plumridge, Andrew [Vis alle 17 forfattere av denne artikkelen] (2014). Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding. Journal of Biological Chemistry. ISSN 0021-9258. 289(19), s. 13492–13502. doi: 10.1074/jbc.M114.549832. Fulltekst i vitenarkiv
  • Sand, Kine Marita Knudsen; Bern, Malin C.; Nilsen, Jeannette; Dalhus, Bjørn; Gunnarsen, Kristin Støen & Cameron, Jason [Vis alle 10 forfattere av denne artikkelen] (2014). Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc Receptor (FcRn). Journal of Biological Chemistry. ISSN 0021-9258. 289(50), s. 34583–34594. doi: 10.1074/jbc.M114.587675.
  • Sand, Kine Marita Knudsen; Dalhus, Bjørn; Christianson, Gregory J.; Bern, Malin C.; Foss, Stian & Cameron, Jason [Vis alle 11 forfattere av denne artikkelen] (2014). Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies. Journal of Biological Chemistry. ISSN 0021-9258. 289(24), s. 17228–17239. doi: 10.1074/jbc.M113.522565. Fulltekst i vitenarkiv
  • Rahman, Mohummad Aminur; Kristiansen, Per Eugen; Veiseth, Silje Veie; Andersen, Jan Terje; Yap, Kyoko L. & Zhou, Ming-Ming [Vis alle 9 forfattere av denne artikkelen] (2014). The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry. ISSN 0006-2960. 53(13), s. 2091–2100. doi: 10.1021/bi401436h.
  • Jung, Sang Taek; Kelton, William; Kang, Tae Hyun; T.W. Ng, Daphne; Andersen, Jan Terje & Sandlie, Inger [Vis alle 8 forfattere av denne artikkelen] (2013). Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High FcγRIIa Affinity and Selectivity. ACS Chemical Biology. ISSN 1554-8929. 8(2), s. 368–375. doi: 10.1021/cb300455f.
  • Yazaki, Paul J.; Lee, Brian; Channappal, Divya; Cheung, Chia-Wei; Crow, Desiree & Chea, Junie [Vis alle 15 forfattere av denne artikkelen] (2013). A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance. Protein Engineering Design & Selection. ISSN 1741-0126. 26(3), s. 187–193. doi: 10.1093/protein/gzs096.
  • Mathiesen, Line; Nielsen, Leif K.; Andersen, Jan Terje; Grevys, Algirdas; Sandlie, Inger & Michaelsen, Terje Einar [Vis alle 9 forfattere av denne artikkelen] (2013). Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions. Blood. ISSN 0006-4971. 122(7), s. 1174–1181. doi: 10.1182/blood-2012-12-473843. Fulltekst i vitenarkiv
  • Lau, Corinna; Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Andersen, Jan Terje; Berntzen, Gøril & Pharo, Anne Margrethe [Vis alle 15 forfattere av denne artikkelen] (2013). Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation. Journal of Immunology. ISSN 0022-1767. 191(9), s. 4769–4777. doi: 10.4049/jimmunol.1301653. Fulltekst i vitenarkiv
  • Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger & Bakke, Oddmund [Vis alle 8 forfattere av denne artikkelen] (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology. ISSN 0014-2980. 43(10), s. 2577–2587. doi: 10.1002/eji.201243203.
  • Andersen, Jan Terje; Cameron, J; Plumridge, A; Sleep, D; Evans, L & Sandlie, Inger (2013). Single-chain Variable Fragment Albumin Fusions Bind the Neonatal Fc Receptor (FcRn) in a Species-dependent Manner: IMPLICATIONS FOR IN VIVO HALF-LIFE EVALUATION OF ALBUMIN FUSION THERAPEUTICS. Journal of Biological Chemistry. ISSN 0021-9258. 288(33), s. 24277–24285. doi: 10.1074/jbc.M113.463000. Fulltekst i vitenarkiv
  • Andersen, Jan Terje; Gonzalez-Pajuelo, Maria; Foss, Stian; Landsverk, Ole J. B.; Pinto, Debora & Szyroki, Alexander [Vis alle 10 forfattere av denne artikkelen] (2013). Selection of Nanobodies that Target Human Neonatal Fc Receptor. Scientific Reports. ISSN 2045-2322. 3. doi: 10.1038/srep01118. Fulltekst i vitenarkiv
  • Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum & Roopenian, Derry C [Vis alle 8 forfattere av denne artikkelen] (2012). Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life. Journal of Biological Chemistry. ISSN 0021-9258. 287(27), s. 22927–22937. doi: 10.1074/jbc.M112.355131. Fulltekst i vitenarkiv
  • Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew & Evans, Leslie [Vis alle 11 forfattere av denne artikkelen] (2012). Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nature Communications. ISSN 2041-1723. 3. doi: 10.1038/ncomms1607. Fulltekst i vitenarkiv
  • Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC & Gerritsen, J. [Vis alle 13 forfattere av denne artikkelen] (2011). Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential. Nature Communications. ISSN 2041-1723. 2. doi: 10.1038/ncomms1608. Fulltekst i vitenarkiv
  • Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa & Doenhoff, Michael [Vis alle 12 forfattere av denne artikkelen] (2011). Polymeric human Fc-fusion proteins with modified effector functions. Scientific Reports. ISSN 2045-2322. 1. doi: 10.1038/srep00124. Fulltekst i vitenarkiv
  • Baker, Kristi; Qiao, Shuo Wang; Kuo, Timothy T.; Aveson, Victoria G.; Platzer, Barbara & Andersen, Jan Terje [Vis alle 12 forfattere av denne artikkelen] (2011). Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8(-)CD11b(+) dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 108(24), s. 9927–9932. doi: 10.1073/pnas.1019037108.
  • Andersen, Jan Terje; Pehrson, Rikard; Tolmachev, Vladimir; Daba, Muluneh Bekele; Abrahamsen, Lars & Ekblad, Caroline (2011). Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain. Journal of Biological Chemistry. ISSN 0021-9258. 286(7), s. 5234–5241. doi: 10.1074/jbc.M110.164848.
  • Andersen, Jan Terje; Daba, Muluneh Bekele & Sandlie, Inger (2010). FcRn binding properties of an abnormal truncated analbuminemic albumin variant. Clinical Biochemistry. ISSN 0009-9120. 43(4-5), s. 367–372. doi: 10.1016/j.clinbiochem.2009.12.001.
  • Andersen, Jan Terje; Daba, Muluneh Bekele; Berntzen, Gøril; Michaelsen, Terje Einar & Sandlie, Inger (2010). Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. Journal of Biological Chemistry. ISSN 0021-9258. 285(7), s. 4826–4836. doi: 10.1074/jbc.M109.081828. Fulltekst i vitenarkiv
  • Andersen, Jan Terje & Sandlie, Inger (2009). The Versatile MHC Class I-related FcRn Protects IgG and Albumin from Degradation: Implications for Development of New Diagnostics and Therapeutics. Drug Metabolism and Pharmacokinetics (DMPK). ISSN 1347-4367. 24(4), s. 318–332.
  • Berntzen, Gøril; Andersen, Jan Terje; Ustgård, Kristine; Ustgård, Kristine; Michaelsen, Terje Einar & Mousavi, Darbi Seyed Ali [Vis alle 13 forfattere av denne artikkelen] (2009). Identification of a High Affinity Fc gamma RIIA-binding Peptide That Distinguishes Fc gamma RIIA from Fc gamma RIIB and Exploits Fc gamma RIIA-mediated Phagocytosis and Degradation. Journal of Biological Chemistry. ISSN 0021-9258. 284(2), s. 1126–1135. doi: 10.1074/jbc.M803584200. Fulltekst i vitenarkiv

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  • Andersen, Jan Terje & Sandlie, Inger (2011). Pharmacokinetics of IgG and albumin: The impact of FcRn for Design of Drug Delivery Systems: The impact of FcRn for Design of Drug Delivery Systems. Wiley-VCH Verlag GmbH. ISBN 9783527328239. 34 s.
  • Andersen, Jan Terje & Sandlie, Inger (2011). Extending Antibody Half Lives with Albumin In: Recombinant Antibodies for Immunotherapy. Cambridge University Press. ISBN 9780521887328. 17 s.
  • Andersen, Jan Terje; Sandlie, Inger; Kenanova, Vania E; Olafsen, Tove & Wu, Anna M (2010). Engineering of the Fc Region for Improved PK (FcRn interaction. Springer-Verlag Berlin Heidelberg . ISBN 978-3-642-01143-6. 19 s.

Se alle arbeider i Cristin

  • König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Vis alle 22 forfattere av denne artikkelen] (2021). Humoral Immunity to SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis using High-Efficacy Disease Modifying Therapies.
  • Grødeland, Gunnveig; Fossum, Even & Andersen, Jan Terje (2020). Vaksinepodden.no: Antistoffer.
  • Jørstad, Øystein Kalsnes; Sivertsen, Magne S.; Andersen, Jan Terje & Moe, Morten Carsten (2020). Kan ampullene med covid-19-vaksine utnyttes bedre? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 20.1039. doi: 10.4045/tidsskr.20.1039.
  • Andersen, Jan Terje (2020). Fikk Trump en magisk cocktail av antistoffer? Aftenposten Viten. ISSN 2464-3033.
  • Andersen, Jan Terje (2019). Design of affordable anti-HIV antibodies.
  • Andersen, Jan Terje (2019). Langtidsvirkende, forebyggende hiv-medisin.
  • Andersen, Jan Terje; Sakya, Siri Aastedatter; Foss, Stian; Sandlie, Inger & Voets, Ardi (2019). Is an HIV vaccine within reach? Vaksinebloggen.
  • Andersen, Jan Terje; Sakya, Siri Aastedatter; Foss, Stian & Sandlie, Inger (2019). Hvordan kan moderne medisin forebygge HIV? Medisinbloggen.
  • Andersen, Jan Terje & Kalveland, Julie (2019). Får millioner til å forske på hiv. [Avis]. Dagens Medisin.
  • Andersen, Jan Terje (2019). Antistoffer kan gi ny hiv-medisin. Aftenposten Viten. ISSN 2464-3033.
  • Vestrum, Alexander & Andersen, Jan Terje (2019). Norske millioner til forskning på hiv-medisin for kvinner . [Tidsskrift]. Bistandsaktuelt.
  • Vestrum, Alexander & Andersen, Jan Terje (2019). Millioner til forskning på hiv-medisin for kvinner. [Avis]. VG.
  • Shaw, Alan; Hoffecker, Ian T.; Smyrlaki, Ioanna; Rosa, João; Grevys, Algirdas & Bryant-Bratlie, Diane Lynn [Vis alle 10 forfattere av denne artikkelen] (2019). Publisher Correction: Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nature Nanotechnology. ISSN 1748-3387. 14(4), s. 398–398. doi: 10.1038/s41565-019-0404-3.
  • Foss, Stian; Michaelsen, Terje Einar; Sandlie, Inger & Andersen, Jan Terje (2011). The Influence of Removal of the IgG Fab Arms on Binding to FcRn. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 350–351. doi: 10.1111/j.1365-3083.2011.02516.x.
  • Tunheim, Gro; Kran, Anne-Marte Bakken; Rø, Gunnar Øyvind Isaksson; Hungnes, Olav; Lund-Johansen, Fridtjof & Tran, Trung [Vis alle 8 forfattere av denne artikkelen] (2020). Seroprevalens av SARS-CoV-2 i den norske befolkningen, målt i restsera samlet inn på sensommeren 2020. Folkehelseinstituttet. ISSN 978-82-8406-155-9.
  • Tunheim, Gro; Kran, Anne-Marte Bakken; Rø, Gunnar Øyvind Isaksson; Steens, Anneke; Hungnes, Olav & Lund-Johansen, Fridtjof [Vis alle 9 forfattere av denne artikkelen] (2020). Seroprevalens av SARS-CoV-2 i den norske befolkningen, målt i restsera samlet inn i april/mai 2020 og august 2019. Folkehelseinstituttet. ISSN 978-82-8406-109-2.
  • Andersen, Jan Terje & Sandlie, Inger (2011). FcRn regulates the pharmacokinetics of albumin. Sojo University Publishing.

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Publisert 22. jan. 2018 09:55 - Sist endret 5. mai 2020 15:12