Øistein Hovde

• Floor, Pål Anders; Farup, Ivar; Pedersen, Marius & Hovde, Øistein (2020). Error reduction through post processing for wireless capsule endoscope video. EURASIP Journal on Image and Video Processing.  ISSN 1687-5176.  (14) . doi: https://doi.org/10.1186/s13640-020-00503-9 Fulltekst i vitenarkiv. Vis sammendrag

  The wireless capsule endoscope (WCE) is a pill-sized device taking images, which are transmitting to an on-body receiver, while traveling through the digestive system. Since image data is transmitted through the human body, which is a harsh medium for electromagnetic wave propagation, noise may at times heavily corrupt the reconstructed image frames. A common way to combat noise is to use error-correcting codes. In addition one may also utilize interand intra frame correlation to reduce the impact of noise at the receiver side, placing no extra demand on the WCE. However, it is then of great importance that the chosen post processing methods do not alter the content of the image as this can lead to miss-detection by gastroenterologists. In this paper we will investigate the possibility for additional noise suppression and error concealment at the receiver side in a high intensity error regime. Due to the high correlation generally inherent in WCE video, satisfactory results are obtained, as concluded from both subjective tests with gastroenterologists as well as the structural similarity (SSIM) metric. More surprisingly, the subjective tests indicate that the inpainted frames in many cases can be used for clinical assessment. These results indicate that one can apply error reduction through post processing together with error-correcting codes to obtain a more noise-robust system without any further demand on the WCE. Keywords: Wireless capsule endoscope, Error reduction and concealment, Image post processing, Subjective testing, Ultra wide band, SSIM

• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2020). Pain Severity and Vitamin D Deficiency in IBD Patients. Nutrients.  ISSN 2072-6643.  12(1), s 1- 12 . doi: 10.3390/nu12010026 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. Keywords: pain severity; patient reported outcomes; vitamin D deficiency.

• Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Småstuen, Milada Cvancarova; Hovde, Øistein; Henriksen, Magne; Huppertz-Hauss, Gert; Günther, Eva Haugset; Moum, Bjørn; Stray, Njaal; Vatn, Morten H; Høie, Ole Ingebreth & Jahnsen, Jørgen (2020). Outcome of Ulcerative Colitis 20 Years after Diagnosis in a Prospective Population-based Inception Cohort from South-Eastern Norway, the IBSEN Study. Journal of Crohn's and colitis.  ISSN 1873-9946. . doi: 10.1093/ecco-jcc/jjaa232 Fulltekst i vitenarkiv. Vis sammendrag

  Background and aims: The long-term course of ulcerative colitis [UC] is difficult to predict. Mortality, colectomy, cancer, and hospitalisation represent hard outcomes of disease. Moreover, knowledge on the risk of relapses and need for potent medication add important information about living with UC. We aimed to evaluate the course and prognosis of UC during the first 20 years after diagnosis, and to identify early prognostic risk factors. Methods: From 1990 to 1994, a population-based inception cohort of patients with inflammatory bowel disease was enrolled in South-Eastern Norway. A systematic follow-up [FU] was conducted at 1,5, 10, and 20 years after diagnosis. Clinical outcomes were recorded continuously, and possible relationships between early disease characteristics and outcomes were analysed using multiple regression analysis. Results: Among 519 UC patients, 119 died, 60 were lost to FU, and 340 were included in the FU cohort. The 20-year cumulative risk of colectomy was 13.0% (95% confidence interval [CI] [11.4-14.6]). Extensive colitis at diagnosis was independently associated with an increased risk of colectomy compared with proctitis (hazard ratio [HR] = 2].8, 95% CI [1.3-6.1]). In contrast, mucosal healing at 1-year FU was independently associated with reduced risk of colectomy [HR = 0.4, 95% CI [0.2-0.8]), and inversely associated with subsequent risk of relapse [adjusted HR = 0.5, 95% CI [0.3-0.7]). Conclusions: The overall risk of colectomy in our cohort was lower than expected from previous studies, although considerable for patients with extensive colitis at diagnosis. Early mucosal healing was associated with better disease outcomes 20 years after diagnosis.

• Klepp, Pasquale Catherine; Brackmann, Stephan; Småstuen, Milada Cvancarova; Høivik, Marte Lie; Hovde, Øistein; Henriksen, Magne; Huppertz-Hauss, Gert; Bernklev, Tomm; Høie, Ole Ingebreth; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Stray, Njaal; Jahnsen, Jørgen; Vatn, Morten H & Moum, Bjørn (2020). Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study. BMJ open gastroenterology.  ISSN 2054-4774.  7 . doi: 10.1136/bmjgast-2019-000361 Fulltekst i vitenarkiv. Vis sammendrag

  Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study. Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88). Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC. Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.

• Mohammed, Ahmed Kedir; Farup, Ivar; Pedersen, Marius; Yildirim Yayilgan, Sule & Hovde, Øistein (2020). PS-DeVCEM: Pathology-sensitive deep learning model for video capsule endoscopy based on weakly labeled data. Computer Vision and Image Understanding.  ISSN 1077-3142.  201:103062, s 1- 11 . doi: 10.1016/j.cviu.2020.103062 Fulltekst i vitenarkiv. Vis sammendrag

  Abstract We propose a novel pathology-sensitive deep learning model (PS-DeVCEM) for frame-level anomaly detection and multi-label classification of different colon diseases in video capsule endoscopy (VCE) data. Our proposed model is capable of coping with the key challenge of colon apparent heterogeneity caused by several types of diseases. Our model is driven by attention-based deep multiple instance learning and is trained end-to-end on weakly labeled data using video labels instead of detailed frame-by-frame annotation. This makes it a cost-effective approach for the analysis of large capsule video endoscopy repositories. Other advantages of our proposed model include its capability to localize gastrointestinal anomalies in the temporal domain within the video frames, and its generality, in the sense that abnormal frame detection is based on automatically derived image features. The spatial and temporal features are obtained through ResNet50 and residual Long short-term memory (residual LSTM) blocks, respectively. Additionally, the learned temporal attention module provides the importance of each frame to the final label prediction. Moreover, we developed a self-supervision method to maximize the distance between classes of pathologies. We demonstrate through qualitative and quantitative experiments that our proposed weakly supervised learning model gives a superior precision and F1-score reaching, 61.6% and 55.1%, as compared to three state-of-the-art video analysis methods respectively. We also show our model’s ability to temporally localize frames with pathologies, without frame annotation information during training. Furthermore, we collected and annotated the first and largest VCE dataset with only video labels. The dataset contains 455 short video segments with 28,304 frames and 14 classes of colorectal diseases and artifacts. Dataset and code supporting this publication will be made available on our home page.

• Mulliqi, Nita; Yildirim Yayilgan, Sule; Mohammed, Ahmed Kedir; Ahmedi, Lule; Wang, Hao; Elezaj, Ogerta & Hovde, Øistein (2020). The Importance Of Skip Connections In Encoder-Decoder Architectures For Colorectal Polyp Detection, In  Proceedings of IEEE international conference on image processing.  IEEE Signal Processing Society.  ISBN 978-1-7281-6395-6.  Chapter.  s 380 - 384 Fulltekst i vitenarkiv.
• Opheim, Randi; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Berset, Ingrid Prytz; Hovde, Øistein; Huppertz-Hauss, Gert; Bernklev, Tomm & Jelsness-Jørgensen, Lars-Petter (2020). Self-esteem in patients with inflammatory bowel disease. Quality of Life Research.  ISSN 0962-9343.  29, s 1839- 1846 . doi: 10.1007/s11136-020-02467-9 Fulltekst i vitenarkiv. Vis sammendrag

  Purpose The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with infammatory bowel disease (IBD), a disease of chronic relapsing infammation of the gastrointestinal tract. IBD symptoms, including pain, fatigue, and diarrhea, as well as potential life-long medical treatment and surgery, may be demanding, cause signifcant challenges, and infuence self-esteem. Methods In this cross-sectional multicenter study, participants were recruited from nine hospitals in the southeastern and western regions of Norway from March 2013 to April 2014. Data were collected using self-report questionnaires. Selfesteem was assessed by the Rosenberg Self-Esteem Scale, fatigue was assessed by the Fatigue Questionnaire, self-efcacy was assessed by the General Self-Efcacy Scale, and disease activity was assessed by the Simple Clinical Colitis Activity Index for ulcerative colitis (UC) and Harvey Bradshaw Index for Crohn’s disease (CD). Multiple linear regression analysis was applied to examine associations between self-esteem and sociodemographic, clinical, and psychological factors. Results In total, 411 of 452 (91%) patients had evaluable data and were included in this study. The mean scores on selfesteem, self-efcacy, total fatigue, anxiety, and depression were similar between UC patients and CD patients. Male gender, being employed, and higher self-efcacy were independently associated with higher self-esteem, whereas anxiety and depression were independently associated with lower self-esteem. Neither disease activity nor fatigue were associated with self-esteem in the fnal multiple regression analyses. Conclusion Patient-centered interventions that improve self-esteem and reduce anxiety and depression seem to be important to optimize IBD management. Keywords Self-esteem · Self-efcacy · Coping · Infammatory bowel disease · Ulcerative colitis · Crohn’s disease · Health psychology · Chronic disease · Health-related quality of life

• Mohammed, Ahmed Kedir; Yildirim Yayilgan, Sule; Farup, Ivar; Pedersen, Marius & Hovde, Øistein (2019). StreoScenNet: Surgical stereo robotic scene segmentation. Progress in Biomedical Optics and Imaging.  ISSN 1605-7422.  1095:109510P1 . doi: 10.1117/12.2512518 Fulltekst i vitenarkiv.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2018). Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  24(29), s 3293- 3301 . doi: 10.3748/wjg.v24.i29.3293
• Mohammed, Ahmed Kedir; Farup, Ivar; Pedersen, Marius; Hovde, Øistein & Yildirim Yayilgan, Sule (2018). Stochastic Capsule Endoscopy Image Enhancement. Journal of Imaging.  ISSN 2313-433X.  4(6) . doi: 10.3390/jimaging4060075 Fulltekst i vitenarkiv.
• Mohammed, Ahmed Kedir; Farup, Ivar; Yildirim, Sule; Pedersen, Marius & Hovde, Øistein (2018). Variational approach for capsule video frame interpolation. EURASIP Journal on Image and Video Processing.  ISSN 1687-5176.  2018:30, s 1- 13 . doi: 10.1186/s13640-018-0267-9 Fulltekst i vitenarkiv.
• Mohammed, Ahmed Kedir; Pedersen, Marius; Hovde, Øistein & Yildirim Yayilgan, Sule (2018). Deep-STRESS Capsule Video Endoscopy Image Enhancement. Color and Imaging Conference (CIC).  ISSN 2166-9635.  s 247- 252 . doi: 10.2352/ISSN.2169-2629.2018.26.247 Fulltekst i vitenarkiv.
• Frigstad, Svein Oskar; Høivik, Marte; Jahnsen, Jørgen; Dahl, Sandra Rinne; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency in inflammatory bowel disease: Prevalence and predictors in a Norwegian outpatient population. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  52(1), s 100- 106 . doi: 10.1080/00365521.2016.1233577 Vis sammendrag

  Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory. Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn’s disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency. Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.

• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi; Henriksen, Magne; Høie, Ole Ingebreth; Hovde, Øistein; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Jahnsen, Jørgen; Hoff, Geir; Moum, Bjørn & Bernklev, Tomm (2017). Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  52(3), s 351- 358 . doi: 10.1080/00365521.2016.1256425
• Mohammed, Ahmed Kedir; Yildirim, Sule; Pedersen, Marius; Hovde, Øistein & Alaya Cheikh, Faouzi (2017). Sparse coded handcrafted and deep features for colon capsule video summarization. Computer-Based Medical Systems.  ISSN 1063-7125.  2017-June, s 728- 733 . doi: 10.1109/CBMS.2017.13 Fulltekst i vitenarkiv.
• Mohammed, Ahmed Kedir; Yildirim, Sule; Pedersen, Marius; Hovde, Øistein & Alaya Cheikh, Faouzi (2017). Sparse coded handcrafted and deep features for colon capsule video summarization, In  Computer-Based Medical Systems (CBMS), 2017 IEEE 30th International Symposium on.  IEEE.  ISBN 978-1-5386-1710-6.  Chapter.  s 728 - 733
• Rukundo, Olivier; Pedersen, Marius & Hovde, Øistein (2017). Advanced Image Enhancement Method for Distant Vessels and Structures in Capsule Endoscopy. Computational & Mathematical Methods in Medicine.  ISSN 1748-670X.  2017, s 1- 13 . doi: 10.1155/2017/9813165 Fulltekst i vitenarkiv. Vis sammendrag

  This paper proposes an advanced method for contrast enhancement of capsule endoscopic images, with the main objective to obtain sufficient information about the vessels and structures in more distant (or darker) parts of capsule endoscopic images. The proposed method (PM) combines two algorithms for the enhancement of darker and brighter areas of capsule endoscopic images, respectively. The half-unit weighted-bilinear algorithm (HWB) proposed in our previous work is used to enhance darker areas according to the darker map content of its HSV’s component . Enhancement of brighter areas is achieved thanks to the novel threshold weighted-bilinear algorithm (TWB) developed to avoid overexposure and enlargement of specular highlight spots while preserving the hue, in such areas. The TWB performs enhancement operations following a gradual increment of the brightness of the brighter map content of its HSV’s component . In other words, the TWB decreases its averaged weights as the intensity content of the component increases. Extensive experimental demonstrations were conducted, and, based on evaluation of the reference and PM enhanced images, a gastroenterologist (Ø.H.) concluded that the PM enhanced images were the best ones based on the information about the vessels, contrast in the images, and the view or visibility of the structures in more distant parts of the capsule endoscopy images.

• Wåhlberg, Henrik; Valle, Per Christian; Malm, Siri; Hovde, Øistein & Broderstad, Ann Ragnhild (2017). The effect of referral templates on out-patient quality of care in a hospital setting: A cluster randomized controlled trial. BMC Health Services Research.  ISSN 1472-6963.  17:177, s 1- 13 . doi: 10.1186/s12913-017-2127-1 Fulltekst i vitenarkiv. Vis sammendrag

  Background The assessment of quality of care is an integral part of modern medicine. The referral represents the handing over of care from the general practitioner to the specialist. This study aimed to assess whether an improved referral could lead to improved quality of care. Methods A cluster randomized trial with the general practitioner surgery as the clustering unit was performed. Fourteen surgeries in the area surrounding the University Hospital of North Norway Harstad were randomized stratified by town versus countryside location. The intervention consisted of implementing referral templates for new referrals in four clinical areas: dyspepsia; suspected colorectal cancer; chest pain; and confirmed or suspected chronic obstructive pulmonary disease. The control group followed standard referral practice. Quality of treatment pathway as assessed by newly developed quality indicators was used as main outcome. Secondary outcomes included subjective quality assessment, positive predictive value of referral and adequacy of prioritization. Assessment of outcomes was done at the individual level. The patients, hospital doctors and outcome assessors were blinded to the intervention status. Results A total of 500 patients were included, with 281 in the intervention and 219 in the control arm. From the multilevel regression model the effect of the intervention on the quality indicator score was insignificant at 1.80% (95% CI, −1.46 to 5.06, p = 0.280). No significant differences between the intervention and the control groups were seen in the secondary outcomes. Active use of the referral intervention was low, estimated at approximately 50%. There was also wide variation in outcome scoring between the different assessors. Conclusions In this study no measurable effect on quality of care or prioritization was revealed after implementation of referral templates at the general practitioner/hospital interface. The results were hindered by a limited uptake of the intervention at GP surgeries and inconsistencies in outcome assessment.

• Eskeland, Sigrun Losada; Brunborg, Cathrine; Seip, Birgitte Karen Berggreen; Wiencke, Kristine; Hovde, Øistein; Owen, Tanja; Skogestad, Erik; Huppertz-Hauss, Gert; Halvorsen, Fred-Arne; Garborg, Kjetil Kjeldstad; Aabakken, Lars & de Lange, Thomas (2016). First quality score for referral letters in gastroenterology—a validation study. BMJ Open.  ISSN 2044-6055.  6(10) . doi: 10.1136/bmjopen-2016-012835 Fulltekst i vitenarkiv. Vis sammendrag

  Abstract Objective To create and validate an objective and reliable score to assess referral quality in gastroenterology. Design An observational multicentre study. Setting and participants 25 gastroenterologists participated in selecting variables for a Thirty Point Score (TPS) for quality assessment of referrals to gastroenterology specialist healthcare for 9 common indications. From May to September 2014, 7 hospitals from the South-Eastern Norway Regional Health Authority participated in collecting and scoring 327 referrals to a gastroenterologist. Main outcome measure Correlation between the TPS and a visual analogue scale (VAS) for referral quality. Results The 327 referrals had an average TPS of 13.2 (range 1–25) and an average VAS of 4.7 (range 0.2–9.5). The reliability of the score was excellent, with an intra-rater intraclass correlation coefficient (ICC) of 0.87 and inter-rater ICC of 0.91. The overall correlation between the TPS and the VAS was moderate (r=0.42), and ranged from fair to substantial for the various indications. Mean agreement was good (ICC=0.47, 95% CI (0.34 to 0.57)), ranging from poor to good. Conclusions The TPS is reliable, objective and shows good agreement with the subjective VAS. The score may be a useful tool for assessing referral quality in gastroenterology, particularly important when evaluating the effect of interventions to improve referral quality.

• Hovde, Øistein; Høivik, Marte Lie; Henriksen, Magne; Solberg, Inger Camilla; Småstuen, Milada Cvancarova & Moum, Bjørn A (2016). Malignancies in Patients with Inflammatory Bowel Disease: Results from 20 Years of Follow-up in the IBSEN Study. Journal of Crohn's and colitis.  ISSN 1873-9946. . doi: 10.1093/ecco-jcc/jjw193
• Hovde, Øistein; Småstuen, Milada C; Høivik, Marte; Bernklev, Tomm; Huppertz-Hauss, Gert; Høie, Ole Ingebreth; Jahnsen, Jørgen; Stray, Njaal; Henriksen, Magne; Solberg, Inger Camilla & Moum, Bjørn (2016). Mortality and Causes of Death in Ulcerative Colitis: Results from 20 Years of Follow-up in the IBSEN Study. Inflammatory Bowel Diseases.  ISSN 1078-0998.  22(1), s 141- 145 . doi: 10.1097/MIB.0000000000000582
• Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm; Hovde, Øistein; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Moum, Bjørn & Høivik, Marte (2016). Patients’ perceptions of quality of care and follow-up in inflammatory bowel disease. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  51(4), s 434- 441 . doi: 10.3109/00365521.2015.1102319
• Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Opheim, Randi; Berset, Ingrid Prytz; Hovde, Øistein; Torp, Roald; Frigstad, Svein Oskar; Huppertz-Hauss, Gert & Bernklev, Tomm (2016). Validity, reliability, and responsiveness of the brief pain inventory in inflammatory bowel disease. Canadian journal of gastroenterology & hepatology.  ISSN 2291-2789.  2016:5624261 . doi: 10.1155/2016/5624261
• Kapica, Aida; Hov, Johannes Espolin Roksund; Borthne, Arne Sigmund; Gleditsch, Jostein; Johannesen, Glenn; Tveit, Knut; Viktil, Ellen; Henriksen, Magne; Hovde, Øistein; Huppertz-Hauss, Gert; Høie, Ole Ingebreth; Høivik, Marte; Kempski-Monstad, Iril Lovise; Solberg, Inger Camilla; Jahnsen, Jørgen; Karlsen, Tom Hemming; Moum, Bjørn; Vatn, Morten H & Negard, Anne (2016). Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease. Gastroenterology.  ISSN 0016-5085.  151(4), s 660- 669 . doi: 10.1053/j.gastro.2016.06.021
• Wanderås, Magnus; Moum, Bjørn; Høivik, Marte Lie & Hovde, Øistein (2016). Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies. World Journal of Gastrointestinal Pharmacology and Therapeutics (WJGPT).  ISSN 2150-5349.  7(2), s 235- 241 . doi: 10.4292/WJGPT.v7.i2.235
• Hovde, Øistein; Huppertz-Hauss, Gert; Høivik, Marte & Moum, Bjørn (2014). Clinical course, treatment strategies, social and economic impact of Ulcerative Colitis: An overview. Austin Journal of Gastroenterology.  ISSN 2381-9219.  1(4), s 1- 9 . doi: id1017
• Hovde, Øistein; Kempski-Monstad, Iril Lovise; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Henriksen, Magne; Jahnsen, Jørgen; Stray, Njaal & Moum, Bjørn (2014). Mortality and causes of death in Crohn's disease: Results from 20 years of follow-up in the IBSEN study. Gut.  ISSN 0017-5749.  63(5), s 771- 775 . doi: 10.1136/gutjnl-2013-304766
• Kempski-Monstad, Iril Lovise; Hovde, Øistein; Solberg, Inger Camilla & Moum, Bjørn (2014). Clinical course and prognosis in ulcerative colitis: Results from population-based and observational studies. Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology..  ISSN 1108-7471.  27(2), s 95- 104 Vis sammendrag

  The clinical course of ulcerative colitis (UC) may range from a quiescent course with prolonged periods of remission to fulminant disease requiring intensive medical treatment or surgery. Disease outcome is often determined by relapse rates, the development of colorectal cancer (CRC) and mortality rates. Early patient classification, identifying those with a high risk of developing complicated disease, is essential for choosing appropriate treatment. This paper reviews the clinical outcomes of UC patients as reported in population-based and observational studies representative of the whole patient population. Extensive colitis, a high level of systemic symptoms and young age at diagnosis are factors associated with a high risk of colectomy. Patients with distal disease who progress to extensive colitis seem to be a subgroup with an especially high risk of colectomy. Some prognostic factors of severe disease have been identified which could be used to optimize treatment and possibly reduce future complications. The overall risk of CRC and mortality was not significantly different from that of the background population. These results may have implications for follow-up strategies, especially regarding endoscopic surveillance of UC patients.

• Moum, Bjørn; Hovde, Øistein & Høivik, Marte (2014). What have we learnt about the role of the environment and natural course of IBD in the new millennium? 20-year follow-up of the IBSEN cohort. Digestive Diseases.  ISSN 0257-2753.  32, s 2- 9 . doi: 10.1159/000367818 Vis sammendrag

  The incidence and prevalence of IBD, both Crohn's disease (CD) and ulcerative colitis (UC), have increased in recent years, especially in industrialized countries. Still, the etiology of IBD remains largely unknown. Most research on IBD before the 1990s was conducted on selected patient populations. Selected patient populations are likely to introduce important bias and limit the interpretation and generalizability. The inclusion of both incident and prevalent cases or the inclusion of incident cases over long periods of time (decades) might also introduce bias due to changes in treatment regimens and socioeconomic factors over timer (time-trend bias). Consequently, the choice of a well-characterized population-based inception cohort provides the best opportunity to describe the natural course of a disease. The IBSEN (Inflammatory Bowel Disease in South-Eastern Norway) study followed a large population-based cohort of newly diagnosed IBD patients for 20 years and has contributed significantly to the knowledge of the natural course of IBD.

• Hovde, Øistein; Lie, Øyvind Haugen; Johansson, Per A; Stubhaug, Øystein; Johnson, Egil; Hofstad, Bjørn & Hauge, Truls (2013). Iatrogenic esophago-tracheal fistula: Challenges in diagnosis and management. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  19(4), s 594- 596 . doi: 10.3748/wjg.v19.i4.594
• Hovde, Øistein & Moum, Bjørn (2012). Epidemiology and clinical course of Crohn's disease: Results from observational studies. World Journal of Gastroenterology (WJG).  ISSN 1007-9327.  18(15), s 1723- 1731 . doi: 10.3748/wjg.v18.i15.1723
• Larssen, Lene; Medhus, Asle Wilhelm; Kørner, Hartwig; Glomsaker, Tom Birger; Søberg, Taran; Gleditsch, Dagfinn; Hovde, Øistein; Tholfsen, Jan Karl; Skreden, Knut; Nesbakken, Arild & Hauge, Truls (2012). Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  47(12), s 1505- 1514 . doi: 10.3109/00365521.2012.711854
• Larssen, Lene; Medhus, Asle Wilhelm; Hjermstad, Marianne Jensen; Kørner, Hartwig; Glomsaker, Tom; Søberg, Taran; Gleditsch, Dagfinn; Hovde, Øistein; Nesbakken, Arild; Tholfsen, Jan Karl; Skreden, Knut & Hauge, Truls (2011). Patient-reported outcomes in palliative gastrointestinal stenting: a Norwegian multicenter study. Surgical Endoscopy.  ISSN 0930-2794.  25(10), s 3162- 3169 . doi: 10.1007/s00464-011-1680-7

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• Kristensen, Vendel Ailin; Lund, Charlotte; Opheim, Randi; Ricanek, Petr; Huppertz-Hauss, Gert; Perminow, Gøri Margrete; Detlie, Trond Espen; Skram, Kristina; Vatn, Simen Svendsen; Olbjørn, Christine; Rove, JA; Stray-Pedersen, Reidulf; Safdar, Muhammad; Pedersen, Aina; Skogestad, Erik; Holm, Hans Kristian; Ystrøm, Carl Magnus; Aballi, B; Torp, Roald; Hovde, Øistein; Frigstad, Svein Oskar; Halvorsen, Fred-Arne; Vikskjold, Florin Berge; Sagosen, Arnt; Bengtson, May-Bente; Aabrekk, Tone Bergene; Andersen, Svend; Hussain, Yassin A.G.; Dahler, Stein; Henriksen, Magne; Løvlund, Emma Elisabeth; Størdal, Ketil; Hasund, Audun; Høie, Ole Ingebreth; Schmidt, K.; Pallenschat, Jens & Høivik, Marte Lie (2020). Inflammatory Bowel Disease in South-Eastern Norway III – IBSEN III.
• Kedir, Ahmed; Yildirim Yayilgan, Sule; Farup, Ivar; Pedersen, Marius & Hovde, Øistein (2018). Y-net: A deep convolutional neural network for polyp detection. https://arxiv.org/abs/1806.01907.
• Mohammed, Ahmed Kedir; Yildirim Yayilgan, Sule; Farup, Ivar; Pedersen, Marius & Hovde, Øistein (2018). Y-Net: A deep convolutional neural network to polyp detection.
• Opheim, Randi; Bernklev, Tomm; Jahnsen, Jørgen; Grimstad, Tore; Hovde, Øistein; Berset, Ingrid Prytz; Frigstad, Svein Oskar & Jelsness-Jørgensen, Lars-Petter (2018). Chronic fatigue in patients with inflammatory bowel disease is associated with lower health–related quality of life, low self-esteem, increased anxiety and depression.
• Frigstad, Svein Oskar; Bernklev, Tomm; Dahl, Sandra Rinne; Hovde, Øistein; Jahnsen, Jørgen; Grimstad, Tore; Berset, Ingrid Prytz; Moum, Bjørn; Huppertz-Hauss, Gert & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with chronic fatigue in inflammatory bowel disease.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Dahl, Sandra Rinne; Cvancarova, Milada; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with depression in IBD patients. Journal of Crohn's and colitis.  ISSN 1873-9946.  11, s 444- 445 . doi: 10.1093/ecco-jcc/jjx002.834
• Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada C; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Fatigue is not Associated with Vitamin D Deficiency in IBD Patients. Gastroenterology.  ISSN 0016-5085.  152(5), s S945 . doi: 10.1016/S0016-5085(17)33218-3
• Frigstad, Svein Oskar; Høivik, Marte Lie; Moum, Bjørn; Dahl, Sandra Rinne; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Torp, Roald; Hovde, Øistein; Bernklev, Tomm & Jelsness-Jørgensen, Lars-Petter (2017). Vitamin D deficiency is not associated with depression in IBD patients.
• Frigstad, Svein Oskar; Høivik, Marte Lie; Småstuen, Milada C; Jahnsen, Jørgen; Dahl, Sandra Rinne; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Grimstad, Tore; Torp, Roald; Bernklev, Tomm; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter (2017). Fatigue er ikke assosiert med vitamin D mangel hos IBD pasienter.
• Hovde, Øistein & Skotte, Kjetil (2017). Menn med ulcerøs colitt dør ikke oftere av kreft. Forskning.no.  ISSN 1891-635X.
• Hovde, Øistein (2016). Clinical outcome of inflammatory bowel disease With special emphasis on mortality and cancer Development. The IBSEN study.
• Jelsness-Jørgensen, Lars-Petter; Lie Høivik, Marte; Moum, Bjørn; Opheim, Randi; Huppertz-Hauss, Gert; Grimstad, Tore; Berset, Ingrid Prytz; Frigstad, Svein Oskar; Hovde, Øistein & Bernklev, Tomm (2015). Fatigue is associated with increased pain intensity and interference in IBD. Inflammatory Bowel Diseases.  ISSN 1078-0998. . doi: 10.1080/00365521
• Hovde, Øistein (2013, 10. juli). Gjøviklege med ny forskning - Vekker oppsikt.  Oppland Arbeiderblad.
• Hovde, Øistein & Moum, Bjørn (2013). Langtidsoppfølging av pasienter med Crohns sykdom - IBSEN-studien finner bedre progose enn tidligere antatt. BestPractice.  9, s 7- 9
• Hauge, Truls; Flø, Reinhardt W & Hovde, Øistein (2005). Praksisveileder – sykehus. Utplasseringen på lokalsykehus i 10. semester.

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