Ola Didrik Saugstad

• Benterud, Torkil; Manueldas, Sophia; Rivera, Santiago; Henckel, Ewa; Løberg, Else Marit; Norgren, Svante; Baumbusch, Lars Oliver; Solberg, Rønnaug & Saugstad, Ola Didrik (2018). Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide. Disease Markers.  ISSN 0278-0240.  2018(5046372) . doi: 10.1155/2018/5046372 Fulltekst i vitenarkiv.
• Bik-Multanowski, Miroslaw; Revhaug, Cecilie; Grabowska, Agnieszka; Dobosz, Artur; Madetko-Talowska, Anna; Zasada, Magdalena & Saugstad, Ola Didrik (2018). Hyperoxia induces epigenetic changes in newborn mice lungs. Free Radical Biology & Medicine.  ISSN 0891-5849.  121, s 51- 56 . doi: 10.1016/j.freeradbiomed.2018.04.566
• Bryn, Vesna; Verkerk, Robert; Skjeldal, Ola; Saugstad, Ola Didrik & Ormstad, Heidi Kristin (2018). Kynurenine pathway in autism spectrum disorders in children. Neuropsychobiology.  ISSN 0302-282X.  76(2), s 82- 88 . doi: 10.1159/000488157
• Huun, Marianne Ullestad; Garberg, Håvard Tetlie; Buonocore, Giuseppe; Longini, Mariangela; Belvisi, Elisa; Bazzini, Francesco; Proietti, Fabrizio; Saugstad, Ola Didrik & Solberg, Rønnaug (2018). Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets. Journal of Perinatal Medicine.  ISSN 0300-5577. . doi: 10.1515/jpm-2017-0355
• Huun, Marianne Ullestad; Garberg, Håvard Tetlie; Løberg, Else Marit; Escobar, Javier; Martinez-Orgado, Jose; Saugstad, Ola Didrik & Solberg, Rønnaug (2018). DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers. PLoS ONE.  ISSN 1932-6203.  13(8) . doi: 10.1371/journal.pone.0201895 Fulltekst i vitenarkiv.
• Oei, Ju Lee; Saugstad, Ola Didrik & Vento, Máximo (2018). Oxygen and preterm infant resuscitation: What else do we need to know?. Current opinion in pediatrics.  ISSN 1040-8703.  30(2), s 192- 198 . doi: 10.1097/MOP.0000000000000610
• Saugstad, Ola Didrik (2018). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Alveolar Arterial Oxygen Gradient in Premature Infants Breathing 100% Oxygen. Journal of Pediatrics.  ISSN 0022-3476.  194, s 66 . doi: 10.1016/j.jpeds.2017.06.017
• Saugstad, Ola Didrik (2018). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Birth Weight, Gestational Age, and Sex as Determining Factors in the Incidence of Respiratory Distress Syndrome of Prematurely Born Infants. Journal of Pediatrics.  ISSN 0022-3476.  197, s 28 . doi: 10.1016/j.jpeds.2017.11.040
• Saugstad, Ola Didrik (2018). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Phenylketonuria: Evaluation of Therapy and Verification of Diagnosis. Journal of Pediatrics.  ISSN 0022-3476.  193, s 92 . doi: 10.1016/j.jpeds.2017.12.035
• Saugstad, Ola Didrik (2018). 50 Years Ago in THE JOURNAL OF PEDIATRICS: The Effect of Pretreatment with Pentobarbital, Meperidine, or Hyperbaric Oxygen on the Response to Anoxia and Resuscitation in Newborn Rabbits. Journal of Pediatrics.  ISSN 0022-3476.  195, s 168 . doi: 10.1016/j.jpeds.2017.10.025
• Saugstad, Ola Didrik (2018). Oxygenation of the Immature Infant: A Commentary and Recommendations for Oxygen Saturation Targets and Alarm Limits. Neonatology.  ISSN 1661-7800.  114(1), s 69- 75 . doi: 10.1159/000486751
• Saugstad, Ola Didrik (2018). Resuscitation of the Newborn, In Giuseppe Buonocore; Rodolfo Bracci & Michael Weindling (ed.),  Neonatology. A Practical Approach to Neonatal Diseases.  Springer.  ISBN 978-3-319-29487-2.  kapittel.  s 1 - 16
• Stenson, Ben & Saugstad, Ola Didrik (2018). Oxygen Treatment for Immature Infants beyond the Delivery Room: Lessons from Randomized Studies. Journal of Pediatrics.  ISSN 0022-3476. . doi: 10.1016/j.jpeds.2018.05.001
• Suski, Maciej; Bokiniec, Renata; Szwarc-Duma, Monika; Madej, Jozef; Bujak-Gizycka, Beata; Borszewska-Kornacka, Maria K.; Ksiazek, Teofila; Grabowska, Agnieszka; Revhaug, Cecilie; Baumbusch, Lars Oliver; Saugstad, Ola Didrik; Pietrzyk, Jacek Jozef & Kwinta, Przemko (2018). Plasma proteome changes in cord blood samples from preterm infants. Journal of Perinatology.  ISSN 0743-8346.  s 1- 8 . doi: 10.1038/s41372-018-0150-7
• Suski, Maciej; Bokiniec, Renata; Szwarc-Duma, Monika; Madej, Józef; Bujak-Giżycka, Beata; Kwinta, Przemko; Borszewska-Kornacka, Maria K.; Revhaug, Cecilie; Baumbusch, Lars Oliver; Saugstad, Ola Didrik & Pietrzyk, Jacek Józef (2018). Prospective plasma proteome changes in preterm infants with different gestational ages. Pediatric Research.  ISSN 0031-3998.  s 1- 8 . doi: 10.1038/s41390-018-0003-2
• Thomas, Anub Mathew; Schjalm, Camilla; Nilsson, Per; Lindenskov, Paal Helge H.; Rørtveit, Runa; Solberg, Rønnaug; Saugstad, Ola Didrik; Berglund, Magnus M.; Strömberg, Patrik; Lau, Corinna; Espevik, Terje; Jansen, Johan Høgset; Castellheim, Albert; Mollnes, Tom Eirik & Barratt-Due, Andreas (2018). Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome. Neonatology.  ISSN 1661-7800.  113(4), s 322- 330 . doi: 10.1159/000486542 Fulltekst i vitenarkiv.
• Umphrey, Lisa; Breindahl, Morten; Brown, Alexandra; Saugstad, Ola Didrik; Thio, Marta; Trevisanuto, Daniele; Roehr, Charles Christoph & Blennow, Mats (2018). When Helping Babies Breathe Is Not Enough: Designing a Novel, Mid-Level Neonatal Resuscitation Algorithm for Medecins Sans Frontieres Field Teams Working in Low-Resource Hospital Settings. Neonatology.  ISSN 1661-7800.  114(2), s 112- 123 . doi: 10.1159/000486705
• Wilson, A; Vento, M; Shah, Prakesh S.; Saugstad, Ola Didrik; Finer, Neil; Rich, Wade; Morton, Rachael L.; Rabi, Yacov; Tarnow-Mordi, William; Suzuki, Keiji; Wright, Ian M. & Oei, Ju Lee (2018). A review of international clinical practice guidelines for the use of oxygen in the delivery room resuscitation of preterm infants. Acta Paediatrica.  ISSN 0803-5253.  107(1), s 20- 27 . doi: 10.1111/apa.14012
• Asadi-Azarbaijani, Babak; Santos, Regiane R.; Jahnukainen, Kirsi; Braber, Saskia; van Duursen, Majorie BM; Toppari, Jorma; Saugstad, Ola Didrik; Nurmio, Mirja & Oskam, Irma Caroline (2017). Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary. Reproductive Biology.  ISSN 1642-431X.  17(1), s 25- 33 . doi: 10.1016/j.repbio.2016.11.003
• Aune, Dagfinn; Schlesinger, Sabrina; Henriksen, Tore; Saugstad, Ola Didrik & Tonstad, Serena (2017). Physical activity and the risk of preterm birth: a systematic review and meta-analysis of epidemiological studies. BJOG: an International Journal of Obstetrics and Gynaecology.  ISSN 1470-0328.  124(12), s 1816- 1826 . doi: 10.1111/1471-0528.14672
• de Lange, Charlotte; Saugstad, Ola Didrik & Solberg, Rønnaug (2017). Assessment of cerebral perfusion with contrast-enhanced ultrasound during constriction of the neck mimicking malposition of the BD Odon Device™: a study in newborn piglets. BJOG: an International Journal of Obstetrics and Gynaecology.  ISSN 1470-0328.  124(S4), s 26- 34 . doi: 10.1111/1471-0528.14751
• Garberg, Håvard Tetlie; Huun, Marianne Ullestad; Baumbusch, Lars Oliver; Atneosen-Åsegg, Monica; Solberg, Rønnaug & Saugstad, Ola Didrik (2017). Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets. Neonatology.  ISSN 1661-7800.  111(2), s 133- 139 . doi: 10.1159/000449032
• Garberg, Håvard Tetlie; Solberg, Rønnaug; Barlinn, Jon; Martinez-Orgado, Jose; Løberg, Else Marit & Saugstad, Ola Didrik (2017). High-dose cannabidiol induced hypotension after global hypoxia-ischemia in piglets. Neonatology.  ISSN 1661-7800.  112(2), s 143- 149 . doi: 10.1159/000471786
• Grytten, Jostein Ivar; Monkerud, Lars Chr.; Skau, Irene; Eskild, Anne; Sørensen, Rune Jørgen & Saugstad, Ola Didrik (2017). Saving Newborn Babies – The Benefits of Interventions in Neonatal Care in Norway over More Than 40 Years. Health Economics.  ISSN 1057-9230.  26(3), s 352- 370 . doi: 10.1002/hec.3314 Fulltekst i vitenarkiv.
• Huun, Marianne Ullestad; Garberg, Håvard Tetlie; Escobar, Javier; Chafer, Consuelo; Vento, Maximo; Holme, Ingar Morten K; Saugstad, Ola Didrik & Solberg, Rønnaug (2017). DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: A study of lipid peroxidation products in urine and plasma. Journal of Perinatal Medicine.  ISSN 0300-5577.  46(2), s 209- 217 . doi: 10.1515/jpm-2016-0334 Fulltekst i vitenarkiv.
• Kuligowski, Julia; Solberg, Rønnaug; Sánchez-Illana, Ángel; Pankratov, Leonid; Parra-Llorca, Anna; Quintas, Guillermo; Saugstad, Ola Didrik & Ventoa, Máximo (2017). Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia. Redox Biology.  ISSN 2213-2317.  12, s 1- 7 . doi: 10.1016/j.redox.2017.02.002
• Kwinta, Przemko; Bokiniec, Renata; Bik-Multanowski, Miroslaw; Günther, Clara-Cecilie; Grabowska, Agnieszka; Ksiazek, Teofila; Madetko-Talowska, Anna; Szewczyk, Katarzyna; Szwarc-Duma, Monika; Borszewska-Kornacka, Maria K.; Baumbusch, Lars Oliver; Revhaug, Cecilie; Saugstad, Ola Didrik & Pietrzyk, Jacek J. (2017). Comparison of whole genome expression profile between preterm and full-term newborns. Ginekologia Polska.  ISSN 0017-0011.  88(8), s 434- 441 . doi: 10.5603/GP.a2017.0080
• Manja, Veena; Saugstad, Ola Didrik & Lakshminrusimha, Satyan (2017). Oxygen saturation targets in preterm infants and outcomes at 18-24 months: A systematic review. Pediatrics.  ISSN 0031-4005.  139(1) . doi: 10.1542/peds.2016-1609
• Oei, Ju Lee; Finer, Neil; Saugstad, Ola Didrik; Wright, Ian M.; Rabi, Yacov; Tarnow-Mordi, William; Rich, Wade; Kapadia, Vishal; Rook, Denise; Smyth, John P.; Lui, Kei & Vento, Máximo (2017). Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  0, s F1- F9 . doi: 10.1136/archdischild-2016-312366
• Oei, Ju Lee; Saugstad, Ola Didrik; Lui, Kei; Wright, Ian M.; Smyth, John P.; Craven, Paul; Wang, Yueping Alex; McMullan, Rowena; Coates, Elisabeth; Ward, Meredith; Mishra, Parag; De Waal, Koert; Travadi, Javeed; See, Kwee Ching; Cheah, Irene G.S.; Lim, Chin Theam; Choo, Yao Mun; Kamar, Azanna Ahmad; Cheah, Fook Choe; Masoud, Ahmed & Tarnow-Mordi, William (2017). Targeted oxygen in the resuscitation of preterm infants, a randomized clinical trial. Pediatrics.  ISSN 0031-4005.  139(1), s 1- 11 . doi: 10.1542/peds.2016-1452
• Oei, Ju Lee; Vento, Máximo; Rabi, Yacov; Wright, Ian; Finer, Neil; Rich, Wade; Kapadia, Vishal; Aune, Dagfinn; Rook, Denise; Tarnow-Mordi, William & Saugstad, Ola Didrik (2017). Higher or lower oxygen for delivery room resuscitation of preterm infants below 28 completed weeks gestation: a meta-analysis. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  102(1), s F24- F30 . doi: 10.1136/archdischild-2016-310435
• Sánchez-Illana, Ángel; Solberg, Rønnaug; Lliso, Isabel; Pankratov, Leonid; Quintas, Guillermo; Saugstad, Ola Didrik; Vento, Máximo & Kuligowski, Julia (2017). Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study. Scientific Reports.  ISSN 2045-2322.  7:40315, s 1- 11 . doi: 10.1038/srep40315
• Saugstad, Ola Didrik (2017). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Effects of Hypoxemia, Hypercarbia, Acidosis, and Reduced Pulmonary Blood Flow on the Surfactant Fetal Lamb Lung. Journal of Pediatrics.  ISSN 0022-3476.  188, s 127 . doi: 10.1016/j.jpeds.2017.03.020
• Saugstad, Ola Didrik (2017). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Feeding Studies in Low-Birth-Weight Infants. Journal of Pediatrics.  ISSN 0022-3476.  184, s 124 . doi: 10.1016/j.jpeds.2016.11.065
• Saugstad, Ola Didrik (2017). 50 Years Ago in THE JOURNAL OF PEDIATRICS: The Incidence of Neonatal Hypoglycemia?A Completed Survey. Journal of Pediatrics.  ISSN 0022-3476.  180, s 73- 73 . doi: 10.1016/j.jpeds.2016.08.014
• Solberg, Rønnaug; Longini, Mariangela; Proietti, Fabrizio; Perrone, Serafina; Felici, Cosetta; Porta, Alessio; Saugstad, Ola Didrik & Buonocore, Giuseppe (2017). DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets. Neonatology.  ISSN 1661-7800.  112(1), s 1- 8 . doi: 10.1159/000454982
• Solevåg, Anne Lee; Schmölzer, Georg M.; Nakstad, Britt; Saugstad, Ola Didrik & Cheung, Po-Yin (2017). Association between Brain and Kidney Near-Infrared Spectroscopy and Early Postresuscitation Mortality in Asphyxiated Newborn Piglets. Neonatology.  ISSN 1661-7800.  112(1), s 80- 86 . doi: 10.1159/000458515
• Sweet, David G.; Carnielli, Virgilio; Greisen, Gorm; Hallman, Mikko; Ozek, Eren; Plavka, Richard; Saugstad, Ola Didrik; Simeoni, Umberto; Speer, Christian P.; Vento, Máximo; Visser, Gerard H.A. & Halliday, Henry L. (2017). European Consensus Guidelines on the management of respiratory distress syndrome - 2016 update. Neonatology.  ISSN 1661-7800.  111(2), s 107- 125 . doi: 10.1159/000448985
• Aschner, Judy L.; Gien, Jason; Ambalavanan, Namasivayam; Kinsella, John P.; Konduri, Girija Ganesh; Lakshminrusimha, Satyan; Saugstad, Ola Didrik & Steinhorn, Robin H. (2016). Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate. Journal of Perinatology.  ISSN 0743-8346.  36(2), s S32- S36 . doi: 10.1038/jp.2016.47
• Aune, Dagfinn; Sen, Abhijit; Henriksen, Tore; Saugstad, Ola Didrik & Tonstad, Serena (2016). Physical activity and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis of epidemiological studies. European Journal of Epidemiology.  ISSN 0393-2990.  31(10), s 967- 997 . doi: 10.1007/s10654-016-0176-0
• Bains, Sukhjeet Kaur; Kumar, Praveen; Sundaram, Venkataseshan; Lang, Astri Maria & Saugstad, Ola Didrik (2016). A Comparison of Health Care Workers Assessment and Management of Pain between a Neonatal Intensive Care Unit in India and Norway. Journal of Palliative Care & Medicine.  ISSN 2165-7386.  6(2) . doi: 10.4172/2165-7386.1000255
• Benterud, Torkil; Ystgaard, Martin Bogale; Manueldas, Sophia; Pankratov, Leonid; Alfaro-Cervello, Clara; Florholmen, Geir; Ahmed, Muhammad Shakil; Sandvik, Leiv; Norgren, Svante; Bjørås, Magnar; Baumbusch, Lars Oliver; Solberg, Rønnaug & Saugstad, Ola Didrik (2016). N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia. Neonatology.  ISSN 1661-7800.  111(1), s 12- 21 . doi: 10.1159/000447255
• Bryn, Vesna; Aass, Hans Christian; Skjeldal, Ola; Isaksen, Jørn; Saugstad, Ola Didrik & Ormstad, Heidi Kristin (2016). Cytokine profile in autism spectrum disorders in children. Journal of Molecular Neuroscience.  ISSN 0895-8696.  61(1), s 1- 7 . doi: 10.1007/s12031-016-0847-z Vis sammendrag

  The pathogenesis of autism spectrum disorders (ASD) is not completely understood, but there is evidence of associations with altered immune responses. The aim of this study was to determine the serum levels of various cytokines in children with ASD and in healthy controls, in order to determine their role in ASD and its diagnostic subgroups. Sixty-five ASD patients were enrolled from an epidemiological survey in Norway, of which 30 were diagnosed with childhood autism, 16 with Asperger syndrome, 12 with atypical autism, 1 with Rett syndrome, and 6 with another ASD diagnosis. The serum levels of 12 cytokines were measured in all of the patients and in 30 healthy children. The cytokine levels did not differ significantly between the ASD group and the healthy controls. However, the interleukin-8 (IL-8) level was significantly higher (6.82 vs 4.58 pg/ml, p = 0.017) while that of IL-10 was significantly lower (2.24 vs 6.49 pg/ml, p = 0.009) in patients with childhood autism than in controls. Furthermore, the IL-8 level was significantly higher in childhood autism than in Asperger syndrome (6.82 vs 4.05 pg/ml, p = 0.013). Our study shows that the cytokine profile of children diagnosed with ASD, regardless of the subdiagnosis, does not differ from healthy controls. However, differentiation into different diagnostic subgroups reveals significantly different levels of IL-8 and IL-10. This indicates that different mechanisms may underlie the different ASD subdiagnoses. Future research into the pathophysiological mechanisms of ASD should pay more attention to the different subdiagnoses of ASD.

• Chafer-Pericas, C.; Torres-Cuevas, Isabel; Sanchez-Illana, A.; Escobar, Javier; Kuligowski, Julia; Solberg, Rønnaug; Garberg, Håvard Tetlie; Huun, Marianne Ullestad; Saugstad, Ola Didrik & Vento, M. (2016). Development of a reliable analytical method to determine lipid peroxidation biomarkers in newborn plasma samples. Talanta: The International Journal of Pure and Applied Analytical Chemistry.  ISSN 0039-9140.  153, s 152- 157 . doi: 10.1016/j.talanta.2016.03.010
• Escobar, Javier; Sánchez-Illana, Ángel; Kuligowski, Julia; Torres-Cuevas, Isabel; Solberg, Rønnaug; Garberg, Håvard Tetlie; Huun, Marianne Ullestad; Saugstad, Ola Didrik; Vento, Máximo & Cháfer-Pericás, Consuelo (2016). Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples. Journal of Pharmaceutical and Biomedical Analysis.  ISSN 0731-7085.  123, s 104- 112 . doi: 10.1016/j.jpba.2016.02.007
• Garberg, Håvard Tetlie; Huun, Marianne Ullestad; Escobar, Javier; Martinez-Orgado, Jose; Løberg, Else Marit; Solberg, Rønnaug & Saugstad, Ola Didrik (2016). Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets. Pediatric Research.  ISSN 0031-3998.  80(5), s 710- 718 . doi: 10.1038/pr.2016.149 Vis sammendrag

  Background: Cannabidiol (CBD), a nonpsychoactive cannabinoid, has shown neuroprotective actions after neonatal hypoxia-ischemia (HI) in animals. We wanted to further explore the effects of CBD, alone and in conjunction with hypothermia, in a piglet model of global HI. Methods: Fifty-five anesthetized newborn piglets were randomized to either controls (n = 7) or HI (n = 48) by ventilation with 8% O2 until mean arterial blood pressure reached 20 mmHg and/or base excess reached −20 mmol/l. After resuscitation piglets were randomized to either: vehicle (VEH), CBD 1mg/kg, VEH+hypothermia (H) or CBD 1mg/kg+H (each n = 12). Piglets were euthanized 9.5 h after HI and plasma, urine, cerebrospinal fluid, and brain tissue were sampled for analysis. Results: HI induced global damage with significantly increased neuropathology score, S100B in cerebrospinal fluid, hippocampal proton magnetic resonance spectroscopy biomarkers, plasma troponin-T, and urinary neutrophil gelatinase-associated lipocalin. CBD alone did not have any significant effects on these parameters while CBD+H reduced urinary neutrophil gelatinase-associated lipocalin compared with VEH+H (P < 0.05). Both hypothermic groups had significantly lower glutamate/N-acetylaspartate ratios (P < 0.01) and plasma troponin-T (P<0.05) levels compared with normothermic groups. Conclusion: In contrast to previous studies, we do not find significant protective effects of CBD after HI in piglets. Evaluation of CBD in higher doses might be warranted.

• Lakshminrusimha, Satyan & Saugstad, Ola Didrik (2016). The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy. Journal of Perinatology.  ISSN 0743-8346.  36(2), s S3- S11 . doi: 10.1038/jp.2016.43
• Oei, Ju Lee; Ghadge, Alpana; Coates, Elisabeth; Wright, Ian M.; Saugstad, Ola Didrik; Vento, Maximo; Buonocore, Giuseppe; Nagashima, Tatsuo; Suzuki, Keiji; Hosono, Shiguhero; Davis, Peter G.; Craven, Paul; Askie, Lisa; Dawson, Jennifer; Garg, Shalabh; Keech, Anthony; Rabi, Yacov; Smyth, John; Sinha, Sunil; Stenson, Ben; Lui, Kei; Hunter, Carol Lu & Tarnow Mordi, William (2016). Clinicians in 25 countries prefer to use lower levels of oxygen to resuscitate preterm infants at birth. Acta Paediatrica.  ISSN 0803-5253.  105(9), s 1061- 1066 . doi: 10.1111/apa.13485
• Rognlien, Anne Gro Wesenberg; Wollen, Embjørg Julianne; Atneosen-Åsegg, Monica & Saugstad, Ola Didrik (2016). Temporal Patterns of Gene Expression Profiles in the Neonatal Mouse Lung after Hypoxia-Reoxygenation. Neonatology.  ISSN 1661-7800.  111(1), s 45- 54 . doi: 10.1159/000447322 Vis sammendrag

  Abstract BACKGROUND: One out of four children with neonatal asphyxia has lung involvement. Still, there has been little research on injury mechanisms of hypoxia-reoxygenation in the neonatal lung. OBJECTIVES: To make a temporal profile of the gene expression changes of 44 a priori selected genes after hypoxia-reoxygenation in the newborn mouse lung, and to compare the changes after hyperoxic and normoxic reoxygenation. METHODS: Postnatal day 7 mice were randomized to 2-hour hypoxia (8% O2) and 30-min reoxygenation in either 60% O2 or air. After 0-72 h of observation, gene expression changes and protein concentrations in whole lung homogenates were examined. RESULTS: Immediately after completed reoxygenation, 7 genes of mediators of inflammation were downregulated, and there was an antiapoptotic gene expression pattern. Three DNA glycosylases were downregulated, while genes involved in cell cycle renewal indicated both increased and decreased cell cycle arrest. Sod1 (T2.5h median H60: 1.01, H21: 0.88, p = 0.005; T5h median H60: 1.04, H21: 0.85, p = 0.038) and Il1b (T0h median H60: 0.86, H21: 1.08, p = 0.021) were significantly differentially expressed when comparing hyperoxic and normoxic reoxygenation. CONCLUSION: In this newborn mouse lung hypoxia-reoxygenation model, we found downregulation of genes of mediators of inflammation, an antiapoptotic gene expression pattern, and downregulation of DNA glycosylases. Sod1 and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.

• Rognum, Torleiv Ole; Holmen, Sigve; Musse, Musse Ahmed; Dahlberg, Pål Skage; Stray-Pedersen, Arne; Saugstad, Ola Didrik & Opdal, Siri Hauge (2016). Estimation of time since death by vitreous humor hypoxanthine, potassium, and ambient temperature. Forensic Science International.  ISSN 0379-0738.  262, s 160- 165 . doi: 10.1016/j.forsciint.2016.03.001
• Saugstad, Ola Didrik; Robertson, Nicola J. & Vento, Maximo (2016). A critical review of the 2015 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant. Acta Paediatrica.  ISSN 0803-5253.  105(5), s 442- 444 . doi: 10.1111/apa.13358
• Saugstad, Ola Didrik & Stokkereit, Ivar (2016). Children's right to health: Implications for decision-making in newborn medical care. Pediatrics.  ISSN 0031-4005.  138(1) . doi: 10.1542/peds.2015-4195
• Solberg, Rønnaug; Kuligowski, Julia; Pankratov, Leonid; Escobar, Javier; Quintas, Guillermo; Lliso, Isabel; Sánchez-Illana, Ángel; Saugstad, Ola Didrik & Vento, Máximo (2016). Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air. Pediatric Research.  ISSN 0031-3998.  80(2), s 284- 292 . doi: 10.1038/pr.2016.66
• Torres-Cuevas, Isabel; Kuligowski, Julia; Carcel, Maria; Cháfer-Pericás, Consuelo; Asensi, Miguel; Solberg, Rønnaug; Cubells, Elena; Nunez, Antonio; Saugstad, Ola Didrik; Vento, Maximo & Escobar, Javier (2016). Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry. Analytica Chimica Acta.  ISSN 0003-2670.  913, s 104- 110 . doi: 10.1016/j.aca.2016.01.054
• Benterud, Torkil; Pankratov, Leonid; Solberg, Rønnaug; Bolstad, Nils; Skinningsrud, Anders; Baumbusch, Lars Oliver; Sandvik, Leiv & Saugstad, Ola Didrik (2015). Perinatal asphyxia may influence the level of beta-amyloid (1-42) in cerebrospinal fluid: An experimental study on newborn pigs. PLoS ONE.  ISSN 1932-6203.  10(10) . doi: 10.1371/journal.pone.0140966
• Curstedt, Tore; Halliday, Henry L.; Hallman, Mikko; Saugstad, Ola Didrik & Speer, Christian P. (2015). 30 Years of Surfactant Research - From Basic Science to New Clinical Treatments for the Preterm Infant. Neonatology.  ISSN 1661-7800. . doi: 10.1159/000381160
• Lindenskov, Paal Helge H.; Castellheim, Albert; Saugstad, Ola Didrik & Mollnes, Tom Eirik (2015). Meconium aspiration syndrome: Possible pathophysiological mechanisms and future potential therapies. Neonatology.  ISSN 1661-7800.  107(3), s 225- 230 . doi: 10.1159/000369373
• Ramji, Siddarth; Saugstad, Ola Didrik & Jain, Ashish (2015). Current Concepts of Oxygen Therapy in Neonates, In Dharmapuri Vidyasagar & Ashok K. Deorari (ed.),  Advances in Neonatology. Current Status and Challenges in Research in India and US.  Indian Journal of Pediatrics.  ISBN 978-81-923838-2-8.  Kapittel 3 Section I.  s 35 - 50
• Ramji, Siddarth; Saugstad, Ola Didrik & Jain, Ashish (2015). Current Concepts of Oxygen Therapy in Neonates. Indian Journal of Pediatrics.  ISSN 0019-5456.  82(1), s 46- 52 . doi: 10.1007/s12098-014-1571-8
• Rognlien, Anne Gro Wesenberg; Wollen, Embjørg Julianne; Atneosen-Åsegg, Monica & Saugstad, Ola Didrik (2015). Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation. Pediatric Research.  ISSN 0031-3998.  77(2), s 326- 333 . doi: 10.1038/pr.2014.193 Vis sammendrag

  Background: Hyperoxic reoxygenation following hypoxia increases the expression of inflammatory genes in the neonatal mouse brain. We have therefore compared the temporal profile of 44 a priori selected genes after hypoxia and hyperoxic or normoxic reoxygenation. Methods: Postnatal day 7 mice were subjected to 2 h of hypoxia (8% O2) and 30 min reoxygenation with 60% or 21% O2. After 0 to 72 h observation, mRNA and protein were examined in hippocampus and striatum. Results: There were significantly higher gene expression changes in six genes after hyperoxic compared to normoxic reoxygenation. Three genes had a generally higher expression throughout the observation period: The inflammatory genes Hmox1 (mean difference: 0.52, 95% confidence interval (CI): 0.15–1.01) and Tgfb1 (mean difference: 0.099, CI: 0.003–0.194), and the transcription factor Nfkb1 (mean difference: 0.049, CI: 0.011–0.087). The inflammatory genes Cxcl10 and Il1b, and the DNA repair gene Neil3, had a higher gene expression change after hyperoxic reoxygenation at one time point only. Nineteen genes involved in inflammation, transcription regulation, apoptosis, angiogenesis, and glucose transport had significantly different gene expression changes with time in all intervention animals. Conclusion: We confirm that hyperoxic reoxygenation induces a stronger inflammatory gene response than reoxygenation with air.

• Samiee-Zafarghandy, Samira; Saugstad, Ola Didrik & Fusch, Christoph (2015). Do we have an answer when it comes to providing extremely preterm infants with optimal target oxygen saturation?. Acta Paediatrica.  ISSN 0803-5253.  104(3), s e130- e133 . doi: 10.1111/apa.12840
• Saugstad, Ola Didrik (2015). Delivery room management of term and preterm newly born infants. Neonatology.  ISSN 1661-7800.  107(4), s 365- 371 . doi: 10.1159/000381159
• Tataranno, ML; Oei, Ju Lee; Perrone, S.; Wright, IM; Smyth, JP; Lui, K.; Tarnow-Mordi, WO; Longini, M; Proietti, Fabrizio; Negro, S.; Saugstad, Ola Didrik & Buonocore, Giuseppe (2015). Resuscitating preterm infants with 100% oxygen is associated with higher oxidative stress than room air. Acta Paediatrica.  ISSN 0803-5253.  104(8), s 759- 765 . doi: 10.1111/apa.13039
• Ystgaard, Martin Bogale; Sejersted, Yngve; Løberg, Else Marit; Lien, Egil; Yndestad, Arne & Saugstad, Ola Didrik (2015). Early upregulation of NLRP3 in the brain of neonatal mice exposed to hypoxia-ischemia: No early neuroprotective effects of NLRP3 deficiency. Neonatology.  ISSN 1661-7800.  108, s 211- 219 . doi: 10.1159/000437247 Vis sammendrag

  Background: The NLRP3 inflammasome acts as an early mediator of inflammation by cleaving and releasing IL-1β and IL-18 from their proforms. Objective: The aim of this study was to describe NLRP3 activation and evaluate whether deficiency of NLRP3 protects against neonatal hypoxic ischemic brain damage. Methods: C57BL/6 and NLRP3-/- mice at P9 were subjected to unilateral common carotid ligation followed by hypoxia. RT-PCR was used on mRNA in five different subregions of the brain. Brain infarction was evaluated by histopathology and 2,3,5-triphenyltetrazolium chloride staining. Plasma levels of IL-18 were measured by ELISA. Double labeling immunohistochemistry was used to examine cell-specific NLRP3 expression. Results: NLRP3 was upregulated 24 h after hypoxia-ischemia (HI) in the hippocampus (2.6-fold), striatum (2.2-fold) and thalamus (2.3-fold). Brain infarction volumes were not statistically significantly different in NLRP3-/- mice compared to WT mice 24 h after HI, accompanied by no significant changes in plasma IL-18 levels. Three hours after HI, NLRP3 expression occurred in astrocytes located in the hippocampus and habenular nucleus of the thalamus. Microglia only showed scarce expression at this time point, but prominent NLRP3 expression 72 h after HI. Conclusion: Astrocytes are early mediators of NLRP3 activity. No early neuroprotective effect of NLRP3 deficiency in neonatal HI brain damage was shown.

• Arduini, Alessandro; Escobar, Javier; Vento, Maximo; Escrig, Raquel; Quintas, Guillermo; Sastre, Juan; Saugstad, Ola Didrik & Solberg, Rønnaug (2014). Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia. Pediatric Research.  ISSN 0031-3998.  76(2), s 127- 134 . doi: 10.1038/pr.2014.70
• Aune, Dagfinn; Saugstad, Ola Didrik; Henriksen, Tore & Tonstad, Serena (2014). Maternal body mass index and the risk of fetal death, stillbirth, and infant death: A systematic review and meta-analysis. Journal of the American Medical Association (JAMA).  ISSN 0098-7484.  311(15), s 1536- 1546 . doi: 10.1001/jama.2014.2269
• Aune, Dagfinn; Saugstad, Ola Didrik; Henriksen, Tore & Tonstad, Serena (2014). Physical Activity and the Risk of Preeclampsia: A Systematic Review and Meta-Analysis. Epidemiology.  ISSN 1044-3983.  25(3), s 331- 343 . doi: 10.1097/EDE.0000000000000036
• Braband, Knut; de Lange, Charlotte; Emblem, Kyrre Eeg; Reinholt, Finn P.; Saugstad, Ola Didrik; Schram Stokke, Eirik & Munkeby, Berit Holthe (2014). Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets. Investigative Radiology.  ISSN 0020-9996.  49(8), s 540- 546 . doi: 10.1097/RLI.0000000000000053
• Dennery, Phyllis A.; Buonocore, Giuseppe & Saugstad, Ola Didrik (2014). Preface (to Perinatal and Prenatal Disorders), In Phyllis A. Dennery; Giuseppe Buonocore & Ola Didrik Saugstad (ed.),  Perinatal and Prenatal Disorders.  Humana Press.  ISBN 978-1-4939-1404-3.  forord.  s v - vi
• Hameed, Numan Nafie; Abdul, Jaleel,RK & Saugstad, Ola Didrik (2014). The use of continuous positive airway pressure in preterm babies with respiratory distress syndrome: A report from Baghdad, Iraq. Journal of Maternal-Fetal & Neonatal Medicine.  ISSN 1476-7058.  27(6), s 629- 632 . doi: 10.3109/14767058.2013.825595
• Kuligowski, J.; Perez-Guaita, D.; Lliso, I.; Escobar, J.; Leon, Z.; Gombau, L.; Solberg, Rønnaug; Saugstad, Ola Didrik; Vento, M. & Quintas, G. (2014). Detection of batch effects in liquid chromatography-mass spectrometry metabolomic data using guided principal component analysis. Talanta: The International Journal of Pure and Applied Analytical Chemistry.  ISSN 0039-9140.  130, s 442- 448 . doi: 10.1016/j.talanta.2014.07.031
• Mitra, Shabana; Aune, Dagfinn; Speer, CP & Saugstad, Ola Didrik (2014). Chorioamnionitis as a Risk factor for retinopathy of prematurity: A systematic review and meta-analysis. Neonatology.  ISSN 1661-7800.  105(3), s 189- 199 . doi: 10.1159/000357556
• Salvesen, Bodil; Curstedt, Tore; Mollnes, Tom Eirik & Saugstad, Ola Didrik (2014). Effects of natural versus synthetic surfactant with SP-B and SP-C analogs in a porcine model of meconium aspiration syndrome. Neonatology.  ISSN 1661-7800.  105(2), s 128- 135 . doi: 10.1159/000356065
• Saugstad, Ola Didrik (2014). Oxygen and Oxidative Stress in the Newborn, In Hirokazu Tsukahara & Kazunari Kaneko (ed.),  Studies on Pediatric Disorders.  Humana Press.  ISBN 978-1-4939-0679-6.  Chapter 1.  s 3 - 13
• Saugstad, Ola Didrik & Aune, Dagfinn (2014). Optimal Oxygenation of Extremely Low Birth Weight Infants: A Meta-Analysis and Systematic Review of the Oxygen Saturation Target Studies. Neonatology.  ISSN 1661-7800.  105(1), s 55- 63 . doi: 10.1159/000356561
• Saugstad, Ola Didrik; Aune, Dagfinn; Aguar, Marta; Kapadia, Vishal; Finer, Neil & Vento, Maximo (2014). Systematic review and meta-analysis of optimal initial fraction of oxygen levels in the delivery room at ≤32 weeks. Acta Paediatrica.  ISSN 0803-5253.  103(7), s 744- 751 . doi: 10.1111/apa.12656
• Solevåg, Anne Lee; Dannevig, Ingrid; Saltyte Benth, Jurate; Saugstad, Ola Didrik & Nakstad, Britt (2014). Reliability of pulse oximetry in hypoxic newborn pigs. Journal of Maternal-Fetal & Neonatal Medicine.  ISSN 1476-7058.  27(8), s 833- 838 . doi: 10.3109/14767058.2013.842550
• Sweet, D; Carnielli, V; Greisen, G; Hallmann, M; Ozek, E; Plavka, R; Saugstad, Ola Didrik; Simeoni, U; Speer, CP & Halliday, HL (2014). [European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants--2013 update]. Zhonghua er ke za zhi.  ISSN 0578-1310.  s 749- 755
• Wollen, Embjørg Julianne; Kwinta, Przemko; Bik-Multanowski, Miroslaw; Madetko-Talowska, Anna; Sejersted, Yngve; Wright, Marianne; Günther, Clara-Cecilie; Nygård, Ståle; Saugstad, Ola Didrik & Pietrzyk, Jacek Jozef (2014). Hypoxia-reoxygenation affects whole-genome expression in the newborn eye. Investigative Ophthalmology and Visual Science.  ISSN 0146-0404.  55(3), s 1393- 1401 . doi: 10.1167/iovs.13-13159 Vis sammendrag

  Purpose. Resuscitation of newborns is one of the most frequent procedures in neonatal medicine. The use of supplementary oxygen during resuscitation of the asphyxiated newborn has been shown to be detrimental to vulnerable tissues. We wanted to assess transcriptional changes in ocular tissue after the acute use of oxygen in the delivery room in a hypoxia–reoxygenation model of the newborn mouse. Methods. C57BL/6 mice (n = 57), postnatal day 7, were randomized to receive either 120 minutes of hypoxia, at 8% O2, followed by 30 minutes of reoxygenation with 21, 40, 60, or 100% O2 or to normoxia followed by 30 minutes of 21% or 100% O2. Whole ocular homogenates were analyzed by Affymetrix 750k expression array, and RT-PCR was performed for validation. Bayesian analysis of variance for microarray data (BAMarray) was used to identify single significant genes, and Gene Set Enrichment Analysis (GSEA) was applied to reveal significant pathway systems. Results. In total, ∼92% of the gene expression changes were altered in response to reoxygenation with 60% or 100% O2 compared to expression at the lower percentages of 21% and 40%. After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated. Pathway analyses after hypoxia–reoxygenation revealed significant alterations of six pathways which included apoptosis, TGF-beta signaling, oxidative phosphorylation, voltage-gated calcium channel complex, mitochondrion, and regulation of RAS protein signal transduction. Conclusions. Hypoxia–reoxygenation can induce immediate transcriptional responses in ocular tissue involving inflammation, angiogenesis, energy failure, and Ras signaling.

• Wollen, Embjørg Julianne; Sejersted, Yngve; Wright, Marianne; Madetko-Talowska, Anna; Bik-Multanowski, Miroslaw; Kwinta, Przemko; Günther, Clara-Cecilie; Nygård, Ståle; Løberg, Else Marit; Ystgaard, Martin Bogale; Pietrzyk, Jacek J. & Saugstad, Ola Didrik (2014). Transcriptome profiling of the newborn mouse brain after hypoxia-reoxygenation: Hyperoxic reoxygenation induces inflammatory and energy failure responsive genes. Pediatric Research.  ISSN 0031-3998.  75(4), s 517- 526 . doi: 10.1038/pr.2013.249 Vis sammendrag

  Background: Supplemental oxygen used during resuscitation can be detrimental to the newborn brain. The aim was to determine how different oxygen therapies affect gene transcription in a hypoxia–reoxygenation model. Methods: C57BL/6 mice (n = 56), postnatal day 7, were randomized either to 120 min of hypoxia 8% O2 followed by 30 min of reoxygenation with 21, 40, 60, or 100% O2, or to normoxia followed by 30 min of 21 or 100% O2. Affymetrix 750k expression array was applied with RT-PCR used for validation. Histopathology and immunohistochemistry 3 d after hypoxia–reoxygenation compared groups reoxygenated with 21 or 100% O2 with normoxic controls (n = 22). Results: In total, ~81% of the gene expression changes were altered in response to reoxygenation with 60 or 100% O2 and constituted many inflammatory-responsive genes (i.e., C5ar2, Stat3, and Ccl12). Oxidative phosphorylation was downregulated after 60 or 100% O2. Iba1+ cells were significantly increased in the striatum and hippocampal CA1 after both 21 and 100% O2. Conclusion: In the present model, hypoxia–reoxygenation induces microglial accumulation in subregions of the brain. The transcriptional changes dominating after applying hyperoxic reoxygenation regimes include upregulating genes related to inflammatory responses and suppressing the oxidative phosphorylation pathway.

• Dannevig, Ingrid; Solevåg, Anne Lee; Sonerud, Tonje; Saugstad, Ola Didrik & Nakstad, Britt (2013). Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system. Pediatric Research.  ISSN 0031-3998.  73(2), s 163- 170 . doi: 10.1038/pr.2012.167 Vis sammendrag

  Background: We compared the current guidelines for neonatal resuscitation with alternative measures and aimed to find out whether this modulated brain inflammation. Methods: Progressive asphyxia was induced in 94 newborn pigs until asystole. With the reference being resuscitation guidelines, 30 s of initial positive-pressure ventilation before compression (C) and ventilation (V) (C:V; 3:1) in 21% oxygen, pigs were randomized to (i) ventilation for 30, 60, or 90 s before chest compressions; (ii) C:V ratios of 3:1, 9:3, or 15:2; or (iii) 21% or 100% oxygen. Concentrations of inflammatory markers in the cerebrospinal fluid (CS F) and gene expression in the hippocampus and frontal cortex were measured for different interventions. Results: In CSF, S100 was higher with 90 s than with 30 or 60 s of initial positive-pressure ventilation, whereas concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were higher with 30 than with 60 s. Matrix metalloproteinase-2 (MMP-2) and intracellular adhesion molecule 1 (ICA M-1) were higher with 30 than with 60 s. No other comparison between ratios and oxygen concentrations used yielded significant results. Conclusion: With respect to signs of brain inflammation, newly born pigs at asystole should be ventilated for longer than 30 s before chest compressions start. C:V ratios of 9:3 and 15:2 as compared with 3:1, or air instead of pure oxygen, did not modulate inflammatory markers.

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• Dennery, Phyllis A.; Buonocore, Giuseppe & Saugstad, Ola Didrik (ed.) (2014). Perinatal and Prenatal Disorders. Humana Press.  ISBN 978-1-4939-1404-3.  435 s.

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• Garberg, Håvard Tetlie; Saugstad, Ola Didrik & Solberg, Rønnaug (2017). Perinatal-Hypoxic-Ischemic Brain Injury: Detection and Intervention.
• Oei, Ju Lee; Wright, Ian M. & Saugstad, Ola Didrik (2017). Authors' response. Pediatrics.  ISSN 0031-4005.  139(5), s 1- 2 . doi: 10.1542/peds.2017-0452B
• Saugstad, Ola Didrik (2017, 26. oktober). Asphyxia in the third millennium: from Virgina Apgar to metabolomics. [Internett].  https://www.youtube.com/watch?v=ruKRWy0uP-k&t=10s.
• Saugstad, Ola Didrik (2017). Kommentar til "Fish Oil in Pregnancy and Asthma in Offspring". New England Journal of Medicine.  ISSN 0028-4793.  376 . doi: 10.1056/NEJMc1701020
• Kessler, Jørg; Yli, Branislava Markovic; Stray-Pedersen, Babill; Jacobsen, Anne Flem; Saugstad, Ola Didrik & Henriksen, Tore (2016). Why did the authors perform a meta-analysis of studies with primary endpoints they consider clinically unimportant?. Acta Obstetricia et Gynecologica Scandinavica.  ISSN 0001-6349.  95(5), s 606- 607 . doi: 10.1111/aogs.12876
• Saugstad, Ola Didrik (2016). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Acetylcholine in the Treatment of Idiopathic Respiratory Distress Syndrome : Moss AJ, Emmanouilides GC, Rettori O, Adams FH. J Pediatrics 1966;69:817-25. Journal of Pediatrics.  ISSN 0022-3476.  178, s 92- 92 . doi: 10.1016/j.jpeds.2016.05.023
• Saugstad, Ola Didrik (2016). Oxygenation of the newborn. Donald School Journal of Ultrasound in Obstetrics and Gynecology.  ISSN 0973-614X.  10(2), s 170- 171 . doi: 10.5005/jp-journals-10009-1462
• Saugstad, Ola Didrik (2016). Re: Kronisk utmattelsessyndrom/ myalgisk encefalopati – sykdomsmekanismer, diagnostikk og behandling. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(3), s 205- 205 . doi: 10.4045/tidsskr.16.0053
• Saugstad, Ola Didrik (2016). The Newborn at the edge of viability. Acta Paediatrica.  ISSN 0803-5253.  105(11), s 1249- 1251 . doi: 10.1111/apa.13564
• Saugstad, Ola Didrik (2016). The neonate from cesarean delivery, In Gian Carlo Di Renzo & Antonio Malvasi (ed.),  Cesarean Delivery.  CRC Press.  ISBN 9781482226331.  Chapter 17.  s 297 - 306
• Vento, Maximo; Schmölzer, Georg; Cheung, Po-Yin; Finer, Neil; Solevåg, Anne Lee; Oei, Ju Lee & Saugstad, Ola Didrik (2016). What initial oxygen is best for preterm infants in the delivery room?-A response to the 2015 neonatal resuscitation guidelines. Resuscitation.  ISSN 0300-9572.  101, s e7- e8 . doi: 10.1016/j.resuscitation.2015.12.020
• Egeland, Torstein; Angelsen, Arild; Haug, Ruth; Henriksen, Jan-Olav; Lea, Tor Erling & Saugstad, Ola Didrik (2015). T. Egeland og medarbeidere svarer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(22), s 2020- 2021 . doi: 10.4045/tidsskr.15.1185
• Egeland, Torstein; Angelsen, Arild; Haug, Ruth; Henriksen, Jan-Olav; Lea, Tor Erling & Saugstad, Ola Didrik (2015). T. Egeland og medarbeidere svarer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(22), s 2021- 2022 . doi: 10.4045/tidsskr.15.1230
• Saugstad, Ola Didrik (2015). Hyperoxia and cerebral vasoconstriction in healthy newborns. Acta Paediatrica.  ISSN 0803-5253.  104(7), s 645- 646 . doi: 10.1111/apa.13004
• Angelsen, Arild; Egeland, Torstein; Haug, Ruth; Henriksen, Jan-Olav; Lea, Tor Erling & Saugstad, Ola Didrik (2014). De ME-syke fortjener seriøs forskning. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Eik-Nes, Sturla; Saugstad, Ola Didrik & Kahrs, Birgitte Heiberg (2014, 08. februar). Ein kompleks prosedyre. Kronikk på ytring.no. [Internett].  nrk.no/ytring.no.
• Haaland, Eilif; Meland, Eivind; Magelssen, Morten; Saugstad, Ola Didrik; Salbu, Harald; Felde, Gunhild & Rognum, Torleiv Ole (2014). Ikke reelt bortfall av henvisningsplikten. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(17), s 1646 . doi: 10.4045/tidsskr.14.1007
• Saugstad, Ola Didrik (2014). Twins should be delivered before 38 weeks of gestation: AGAINST.. BJOG: an International Journal of Obstetrics and Gynaecology.  ISSN 1470-0328. . doi: 10.1111/1471-0528.12916

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