Pål Aukrust

• Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma & Tonby, Kristian [Vis alle 15 forfattere av denne artikkelen] (2021). Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. Journal of Neurology. ISSN 0340-5354. doi: 10.1007/s00415-021-10517-6 Fulltekst i vitenarkiv
• Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K. & Hansen, John-Bjarne [Vis alle 7 forfattere av denne artikkelen] (2021). Plasma levels of leptin and risk of future incident venous thromboembolism. Thrombosis and Haemostasis. ISSN 0340-6245. doi: 10.1055/s-0041-1732295
• Ueland, Thor; Abraityte, Judita Aurelija; Norum, Hilde; Varathalingam, Sharanga; Gullestad, Lars & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulating regulators of the wingless pathway in precapillary pulmonary hypertension. Respirology (Carlton South. Print). ISSN 1323-7799. 26(6), s. 574–581. doi: 10.1111/resp.14048 Fulltekst i vitenarkiv
• Awoyemi, Ayodeji Olawale; Mayerhofer, Christiane Caroline; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D. & Lappegård, Knut Tore [Vis alle 23 forfattere av denne artikkelen] (2021). Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine. ISSN 2352-3964. 70. doi: 10.1016/j.ebiom.2021.103511 Fulltekst i vitenarkiv
• Thorsen, Inga Strand; Gøransson, Lasse Gunnar; Ueland, Thor; Aukrust, Pål; Manhenke, Cord A & Skadberg, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2021). The relationship between Fibroblast Growth Factor 23 (FGF23) and cardiac MRI findings following primary PCI in patients with acute first time STEMI. International journal of cardiology: Heart and Vasculature (IJCHA). ISSN 2352-9067. 33:100727, s. 1–6. doi: 10.1016/j.ijcha.2021.100727 Fulltekst i vitenarkiv
• Barratt-Due, Andreas; Olsen, Inge Christoffer; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Lund-Johansen, Fridtjof & Hoel, Hedda Benedicte [Vis alle 43 forfattere av denne artikkelen] (2021). Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Annals of Internal Medicine. ISSN 0003-4819. doi: 10.7326/M21-0653 Vis sammendrag

  Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known. Objective: To evaluate the effects of remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx. Design: NOR-Solidarity is an independent, add-on, randomized controlled trial to the WHO Solidarity trial that included biobanking and 3 months of clinical follow-up (ClinicalTrials.gov: NCT04321616). Setting: 23 hospitals in Norway. Patients: Eligible patients were adults hospitalized with confirmed SARS-CoV-2 infection. Intervention: Between 28 March and 4 October 2020, a total of 185 patients were randomly assigned and 181 were included in the full analysis set. Patients received remdesivir (n = 42), HCQ (n = 52), or standard of care (SoC) (n = 87). Measurements: In addition to the primary end point of WHO Solidarity, study-specific outcomes were viral clearance in oropharyngeal specimens, the degree of respiratory failure, and inflammatory variables. Results: No significant differences were seen between treatment groups in mortality during hospitalization. There was a marked decrease in SARS-CoV-2 load in the oropharynx during the first week overall, with similar decreases and 10-day viral loads among the remdesivir, HCQ, and SoC groups. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammatory variables in plasma or serum. The lack of antiviral effect was not associated with symptom duration, level of viral load, degree of inflammation, or presence of antibodies against SARS-CoV-2 at hospital admittance. Limitation: The trial had no placebo group. Conclusion: Neither remdesivir nor HCQ affected viral clearance in hospitalized patients with COVID-19.

• Fraz, Mai Sasaki Aanensen; Moe, Natasha; Rootwelt-Revheim, Mona-Elisabeth; Stavrinou, Maria; Durheim, Michael & Nordøy, Ingvild [Vis alle 11 forfattere av denne artikkelen] (2021). Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency—Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.617985 Fulltekst i vitenarkiv
• Edvardsen, Magnus; Hindberg, Kristian; Hansen, Ellen-Sofie; Morelli, Vania Maris; Ueland, Thor & Aukrust, Pål [Vis alle 9 forfattere av denne artikkelen] (2021). Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism. Blood Advances. ISSN 2473-9529. 5(1), s. 224–232. doi: 10.1182/bloodadvances.2020003135 Fulltekst i vitenarkiv
• Bjørkto, Magnus Holter; Barratt-Due, Andreas; Nordøy, Ingvild; Dörje, Christina; Galteland, Eivind & Lind, Andreas [Vis alle 9 forfattere av denne artikkelen] (2021). The use of eculizumab in Capnocytophaga canimorsus associated thrombotic microangiopathy: a case report. BMC Infectious Diseases. ISSN 1471-2334. 21:137, s. 1–6. doi: 10.1186/s12879-021-05789-2
• Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Vis alle 13 forfattere av denne artikkelen] (2021). Instability in nad⁺ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, s. 1–23. doi: 10.7554/ELIFE.59828 Fulltekst i vitenarkiv
• Ueland, Thor; Astrup, Elisabeth; Otterdal, Kari; Lekva, Tove; Janardhanan, Jeshina & Prakash, John A. [Vis alle 11 forfattere av denne artikkelen] (2021). Secreted wnt antagonists in scrub typhus. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 15(4). doi: 10.1371/journal.pntd.0009185 Fulltekst i vitenarkiv
• Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato & Lauritzen, Trine [Vis alle 12 forfattere av denne artikkelen] (2021). Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia. Open Forum Infectious Diseases. ISSN 2328-8957. 8(4). doi: 10.1093/ofid/ofab082 Fulltekst i vitenarkiv
• Engh, John; Ueland, Thor; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål & Boye, Birgitte [Vis alle 27 forfattere av denne artikkelen] (2021). Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study. Schizophrenia Bulletin. ISSN 0586-7614. doi: 10.1093/schbul/sbab106
• Pan, Hongchao; Peto, Richard; Henao-Restrepo, Ana Maria; Preziosi, Marie-Pierre; Sathiyamoorthy, Vasee & Karim, Quarraisha Abdool [Vis alle 74 forfattere av denne artikkelen] (2020). Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results. New England Journal of Medicine. ISSN 0028-4793. 384(6), s. 497–511. doi: 10.1056/NEJMoa2023184
• Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter & Vågbø, Cathrine [Vis alle 17 forfattere av denne artikkelen] (2020). Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Research (NAR). ISSN 0305-1048. 48(8), s. 4463–4479. doi: 10.1093/nar/gkaa115 Fulltekst i vitenarkiv
• Ueland, Thor; Estensen, Mette-Elise; Grindheim, Guro; Bollerslev, Jens; Henriksen, Tore & Aukrust, Pål [Vis alle 9 forfattere av denne artikkelen] (2020). Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies. Journal of Hypertension. ISSN 0263-6352. 38(7), s. 1347–1354. doi: 10.1097/HJH.0000000000002362 Fulltekst i vitenarkiv
• Tholin, Birgitte; Hauge, Marit Teigen; Aukrust, Pål; Fehrle, Lutz & Tvedt, Tor Henrik Anderson (2020). Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report. Journal of Medical Case Reports. ISSN 1752-1947. 14:187, s. 1–5. doi: 10.1186/s13256-020-02503-9 Fulltekst i vitenarkiv
• Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian & Pischke, Soeren [Vis alle 22 forfattere av denne artikkelen] (2020). Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports. ISSN 2045-2322. 10. doi: 10.1038/s41598-020-78710-7 Fulltekst i vitenarkiv
• Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor & Michelsen, Annika [Vis alle 15 forfattere av denne artikkelen] (2020). Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.13178 Fulltekst i vitenarkiv
• Quiles Jimenez, Ana Maria Teresa; Gregersen, Ida; Sousa, Mirta; Abbas, Azhar; Kong, Xiang Yi & Alseth, Ingrun [Vis alle 13 forfattere av denne artikkelen] (2020). N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 533(4), s. 631–637. doi: 10.1016/j.bbrc.2020.09.057 Fulltekst i vitenarkiv
• Nordøy, Ingvild; Fraz, Mai Sasaki Aanensen; Trøseid, Marius; Fevang, Børre & Aukrust, Pål (2020). Høyt serum-ferritin ikke kun uttrykk for leversvikt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(8). doi: 10.4045/tidsskr.20.0376
• Aamodt, Anne Hege; Harbo, Hanne Flinstad; Eldøen, Guttorm; Barratt-Due, Andreas & Aukrust, Pål (2020). Hvordan påvirkes hjernen ved covid-19? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(10), s. 968–969. doi: 10.4045/tidsskr.20.0444
• Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud & Alfsnes, Katrine [Vis alle 25 forfattere av denne artikkelen] (2020). Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction. JACC: Basic to Translational Science. ISSN 2452-302X. 5(12), s. 1210–1224. doi: 10.1016/j.jacbts.2020.09.013 Fulltekst i vitenarkiv
• Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette & Rinholm, Johanne Egge [Vis alle 21 forfattere av denne artikkelen] (2020). OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. Cell reports. ISSN 2211-1247. 30(12), s. 4165–4178. doi: 10.1016/j.celrep.2020.02.063 Fulltekst i vitenarkiv
• Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Maria Cornelia; Kummen, Martin & Hov, Johannes Espolin Roksund [Vis alle 12 forfattere av denne artikkelen] (2020). NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet. Scientific Reports. ISSN 2045-2322. 10:21006, s. 1–16. doi: 10.1038/s41598-020-76497-1 Fulltekst i vitenarkiv
• Lekva, Tove; Gullestad, Lars; Broch, Kaspar; Aukrust, Pål; Andreassen, Arne K. & Ueland, Thor (2020). Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension. Scientific Reports. ISSN 2045-2322. 10(1), s. 1–8. doi: 10.1038/s41598-020-75654-w Fulltekst i vitenarkiv
• Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne & Holten, Aleksander Rygh [Vis alle 32 forfattere av denne artikkelen] (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients . Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(40), s. 25018–25025. doi: 10.1073/pnas.2010540117 Fulltekst i vitenarkiv
• Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika & Lekva, Tove [Vis alle 19 forfattere av denne artikkelen] (2020). YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circulation: Heart Failure. ISSN 1941-3289. 13(10). doi: 10.1161/CIRCHEARTFAILURE.119.006643 Fulltekst i vitenarkiv
• Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian & Michelsen, Annika [Vis alle 26 forfattere av denne artikkelen] (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 147(1), s. 92–98. doi: 10.1016/j.jaci.2020.09.007 Fulltekst i vitenarkiv
• Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca & Hammarström, Clara Louise [Vis alle 15 forfattere av denne artikkelen] (2020). Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLOS ONE. ISSN 1932-6203. 15:e0243759(12), s. 1–14. doi: 10.1371/journal.pone.0243759 Fulltekst i vitenarkiv
• Hovland, Anders; Narverud, Ingunn; Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Aagnes, Inger & Ueland, Thor [Vis alle 17 forfattere av denne artikkelen] (2020). Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers. Journal of Clinical Lipidology. ISSN 1933-2874. s. 1–8. doi: 10.1016/j.jacl.2020.12.006 Fulltekst i vitenarkiv
• Niyonzima, Nathalie; Bakke, Siril Skaret; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein & Orrem, Hilde Lang [Vis alle 22 forfattere av denne artikkelen] (2020). Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine. ISSN 2352-3964. 60:102985, s. 1–13. doi: 10.1016/j.ebiom.2020.102985 Fulltekst i vitenarkiv
• Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin & Otterdal, Kari [Vis alle 14 forfattere av denne artikkelen] (2020). Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.574500 Fulltekst i vitenarkiv
• Shahini, Negar; Schjalm, Camilla; Nilsson, Per; Holt, Margrethe Flesvig; Øgaard, Jonas & Lien, Egil [Vis alle 12 forfattere av denne artikkelen] (2020). Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 523(4), s. 867–873. doi: 10.1016/j.bbrc.2020.01.018 Fulltekst i vitenarkiv
• Berg, Åse; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Dalen, Ingvild & Otterdal, Kari [Vis alle 10 forfattere av denne artikkelen] (2020). Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection. Infection. ISSN 0300-8126. 48, s. 367–373. doi: 10.1007/s15010-020-01399-3 Fulltekst i vitenarkiv
• Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Vis alle 18 forfattere av denne artikkelen] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, s. 1–9. doi: 10.1038/s41598-020-62261-y Fulltekst i vitenarkiv
• Hovland, Anders; Retterstøl, Kjetil; Mollnes, Tom Eirik; Halvorsen, Bente Evy; Aukrust, Pål & Lappegård, Knut Tore (2020). Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential? Scandinavian Cardiovascular Journal. ISSN 1401-7431. s. 1–7. doi: 10.1080/14017431.2020.1775878 Fulltekst i vitenarkiv
• Mayerhofer, Christiane Caroline; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale & Vestad, Beate [Vis alle 17 forfattere av denne artikkelen] (2020). Low fibre intake is associated with gut microbiota alterations in chronic heart failure. ESC Heart Failure. ISSN 2055-5822. 7(2), s. 456–466. doi: 10.1002/ehf2.12596 Fulltekst i vitenarkiv
• Aimo, Alberto; Januzzi, James L.; Vergaro, Giuseppe; Richards, A. Mark; Lam, Carolyn S.P. & Latini, Roberto [Vis alle 32 forfattere av denne artikkelen] (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure. ISSN 1388-9842. s. 1–11. doi: 10.1002/ejhf.1701 Fulltekst i vitenarkiv
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Gregersen, Ida & Sagen, Ellen Lund [Vis alle 11 forfattere av denne artikkelen] (2020). Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: Potential immune-regulatory role during malaria. BMC Infectious Diseases. ISSN 1471-2334. 20(65), s. 1–11. doi: 10.1186/s12879-020-4783-8 Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund & Johannessen, Cecilie Haggag [Vis alle 13 forfattere av denne artikkelen] (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia. ISSN 2334-265X. 6, s. 1–8. doi: 10.1038/s41537-020-00112-5 Fulltekst i vitenarkiv
• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars ; Inderhaug, Elin; Hughes, Timothy & Steen, Nils Eiel [Vis alle 10 forfattere av denne artikkelen] (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, behavior, and immunity. ISSN 0889-1591. 87, s. 634–644. doi: 10.1016/j.bbi.2020.02.008 Fulltekst i vitenarkiv
• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid & Bjella, Thomas [Vis alle 12 forfattere av denne artikkelen] (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry. ISSN 1664-0640. 11, s. 1–10. doi: 10.3389/fpsyt.2020.00642 Fulltekst i vitenarkiv
• Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica & Vedal, Trude Seselie Jahr [Vis alle 18 forfattere av denne artikkelen] (2020). Atherogenic lipid ratios related to myeloperoxidase and C-reactive protein levels in psychotic disorders. Frontiers in Psychiatry. ISSN 1664-0640. 11. doi: 10.3389/fpsyt.2020.00672 Fulltekst i vitenarkiv
• Hoel, Hedda Benedicte; Ueland, Thor; Knudsen, Andreas; Kjær, Andreas; Michelsen, Annika & Sagen, Ellen Lund [Vis alle 12 forfattere av denne artikkelen] (2020). Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals. Journal of Infectious Diseases. ISSN 0022-1899. 221(4), s. 506–509. doi: 10.1093/infdis/jiz253
• Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas & Svalheim, Sigrid (2020). Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure. ISSN 1059-1311. 80, s. 221–225. doi: 10.1016/j.seizure.2020.05.018 Fulltekst i vitenarkiv
• Hoel, Hedda Benedicte; Ueland, Thor; Hove-Skovsgaard, Malene; Hartling, Hans Jakob; Gelpi, Marco & Benfield, Thomas [Vis alle 11 forfattere av denne artikkelen] (2020). Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection. Open Forum Infectious Diseases. ISSN 2328-8957. 29(7). doi: 10.1093/ofid/ofaa033 Fulltekst i vitenarkiv
• Sikkeland, Liv Ingunn Bjoner; Qiao, Shuo Wang; Ueland, Thor; Myrdal, Ole Henrik; Wyrozemski, Lukasz Adam & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2020). Lung CD4+ T cells in patients with lung fibrosis produce pro-fibrotic IL-13 together with IFNγ. European Respiratory Journal. ISSN 0903-1936. 57:2000983(3), s. 1–4. doi: 10.1183/13993003.00983-2020 Fulltekst i vitenarkiv
• Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G. & Skjelland, Mona [Vis alle 20 forfattere av denne artikkelen] (2020). Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. Journal of the American Heart Association (JAHA). ISSN 2047-9980. e016360. doi: 10.1161/JAHA.120.016360 Fulltekst i vitenarkiv
• George, Marc J; Kleveland, Ola; Garcia-Hernandez, Jorge; Palmen, Jutta; Lovering, Ruth & Wiseth, Rune [Vis alle 13 forfattere av denne artikkelen] (2020). Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 16(12), s. 1–21. doi: 10.1161/JAHA.119.015628 Fulltekst i vitenarkiv Vis sammendrag

  Background Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non-ST-segment-elevation myocardial infarction trial, the first randomized trial of interleukin 6 blockade in myocardial infarction, concentration of both C-reactive protein and troponin T were reduced in the active treatment arm. In this follow-up study, an aptamer-based proteomic approach was employed to discover additional plasma proteins modulated by tocilizumab treatment to gain novel insights into the effects of this therapeutic approach. Methods and Results Plasma from percutaneous coronary intervention-treated patients, 24 in the active intervention and 24 in the placebo-control arm, drawn 48 hours postrandomization were randomly selected for analysis with the SOMAscan assay. Employing slow off-rate aptamers, the relative abundance of 1074 circulating proteins was measured. Proteins identified as being significantly different between groups were subsequently measured by enzyme immunoassay in the whole trial cohort (117 patients) at all time points (days 1-3 [7 time points] and 3 and 6 months). Five proteins identified by the SOMAscan assay, and subsequently confirmed by enzyme immunoassay, were significantly altered by tocilizumab administration. The acute-phase proteins lipopolysaccharide-binding protein, hepcidin, and insulin-like growth factor-binding protein 4 were all reduced during the hospitalization phase, as was the monocyte chemoattractant C-C motif chemokine ligand 23. Proteinase 3, released primarily from neutrophils, was significantly elevated. Conclusions Employing the SOMAscan aptamer-based proteomics platform, 5 proteins were newly identified that are modulated by interleukin 6 antagonism and may mediate the therapeutic effects of tocilizumab in non-ST-segment-elevation myocardial infarction.

• Hansen, Ellen-Sofie; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor & Hansen, John-Bjarne [Vis alle 8 forfattere av denne artikkelen] (2020). Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism. Blood. ISSN 0006-4971. 136(16), s. 1863–1870. doi: 10.1182/blood.2019004572 Fulltekst i vitenarkiv
• Narverud, Ingunn; Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2019). Profiling of immune-related gene expression in children with familial hypercholesterolaemia. Journal of Internal Medicine. ISSN 0954-6820. s. 1–12. doi: 10.1111/joim.13001 Fulltekst i vitenarkiv
• Yang, Kuan; Lauritzen, Knut Husø; Olsen, Maria Belland; Dahl, Tuva Børresdatter; Ranheim, Trine & Ahmed, Muhammad Shakil [Vis alle 12 forfattere av denne artikkelen] (2019). Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes. Journal of Immunology. ISSN 0022-1767. 203(6), s. 1598–1608. doi: 10.4049/jimmunol.1801382
• Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine & Vinge, Leif Erik [Vis alle 10 forfattere av denne artikkelen] (2019). Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts. Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01285 Fulltekst i vitenarkiv
• Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H. & Sagen, Ellen [Vis alle 15 forfattere av denne artikkelen] (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine. ISSN 2352-3964. 46, s. 264–273. doi: 10.1016/j.ebiom.2019.07.024 Fulltekst i vitenarkiv
• Narverud, Ingunn; Bogsrud, Martin Prøven; Øyri, Linn Kristin Lie; Ulven, Stine Marie; Retterstøl, Kjetil & Ueland, Thor [Vis alle 12 forfattere av denne artikkelen] (2019). Lipoprotein (a) concentration is associated with plasma arachidonic acid in subjects with familial hypercholesterolemia. British Journal of Nutrition. ISSN 0007-1145. doi: 10.1017/S0007114519001600 Fulltekst i vitenarkiv
• Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K & Hussain, Amjad Iqbal [Vis alle 17 forfattere av denne artikkelen] (2019). Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis. Journal of Immunology. ISSN 0022-1767. 203(7), s. 1973–1980. doi: 10.4049/jimmunol.1801244 Fulltekst i vitenarkiv
• Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M. & Hov, Johannes Espolin Roksund [Vis alle 14 forfattere av denne artikkelen] (2019). The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 38(10), s. 1097–1103. doi: 10.1016/j.healun.2019.06.003 Fulltekst i vitenarkiv
• Sokolova, Marina; Ranheim, Trine; Louwe, Maria Cornelia; Halvorsen, Bente; Yndestad, Arne & Aukrust, Pål (2019). NLRP3 inflammasome: A novel player in metabolically induced inflammation-potential influence on the myocardium. Journal of Cardiovascular Pharmacology. ISSN 0160-2446. 74(4), s. 276–284. doi: 10.1097/FJC.0000000000000704 Fulltekst i vitenarkiv
• Dimopoulou, Chrysoula; Lundgren, Jens D.; Sundal, Jon; Ullum, Henrik; Aukrust, Pål & Nielsen, Finn C. [Vis alle 7 forfattere av denne artikkelen] (2019). Variant in ERAP1 promoter region is associated with low expression in a patient with a Behcet-like MHC-I-opathy. Journal of Human Genetics. ISSN 1434-5161. 65, s. 325–335. doi: 10.1038/s10038-019-0709-y
• Solberg, Ole Geir; Stavem, Knut; Ragnarsson, Asgrimur; Beitnes, Jan Otto; Skårdal, Rita & Seljeflot, Ingebjørg [Vis alle 10 forfattere av denne artikkelen] (2019). Index of microvascular resistance to assess the effect of rosuvastatin on microvascular function in women with chest pain and no obstructive coronary artery disease: A double-blind randomized study. Catheterization and cardiovascular interventions. ISSN 1522-1946. 94(5), s. 660–668. doi: 10.1002/ccd.28157 Fulltekst i vitenarkiv
• Quist-Paulsen, Else; Ormaasen, Vidar; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ueland, Per Magne & Ueland, Thor [Vis alle 9 forfattere av denne artikkelen] (2019). Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning. Scientific Reports. ISSN 2045-2322. 9. doi: 10.1038/s41598-019-52570-2 Fulltekst i vitenarkiv
• Gregersen, Ida; Høibraaten, Else; Holven, Kirsten Bjørklund; Løvdahl, Lene; Ueland, Thor & Mowinckel, Marie-Christine [Vis alle 10 forfattere av denne artikkelen] (2019). Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women. Thrombosis Research. ISSN 0049-3848. 184, s. 1–7. doi: 10.1016/j.thromres.2019.10.005 Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Reponen, Elina Johanna [Vis alle 13 forfattere av denne artikkelen] (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology. ISSN 0306-4530. 112:104513, s. 1–7. doi: 10.1016/j.psyneuen.2019.104513 Fulltekst i vitenarkiv
• Nome, Marianne Eikhom; Euceda, Leslie R.; Jabeen, Shakila; Debik, Julia; Bathen, Tone Frost & Giskeødegård, Guro F. [Vis alle 17 forfattere av denne artikkelen] (2019). Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers. International Journal of Cancer. ISSN 0020-7136. 146(1), s. 223–235. doi: 10.1002/ijc.32638 Fulltekst i vitenarkiv
• Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein & Bendiksen, Bård Andre [Vis alle 14 forfattere av denne artikkelen] (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 316(6), s. L999–L1012. doi: 10.1152/ajplung.00322.2018 Fulltekst i vitenarkiv
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C. & Bertilsson, Maria [Vis alle 13 forfattere av denne artikkelen] (2019). Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 39(2), s. 294–302. doi: 10.1161/ATVBAHA.118.311042
• Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål & Henriksen, Tore [Vis alle 8 forfattere av denne artikkelen] (2019). Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later. Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972X. doi: 10.1210/clinem/dgz119 Fulltekst i vitenarkiv
• Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews. ISSN 1520-7552. :e3114, s. 1–9. doi: 10.1002/dmrr.3114 Fulltekst i vitenarkiv
• Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore & Bollerslev, Jens [Vis alle 10 forfattere av denne artikkelen] (2019). Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children. Molecular Nutrition & Food Research. ISSN 1613-4125. 63(7). doi: 10.1002/mnfr.201800990 Fulltekst i vitenarkiv
• Nyakas, Marta Sølvi; Aamdal, Elin; Jacobsen, Kari Dolven; Guren, Tormod Kyrre; Aamdal, Steinar & Hagene, Kirsten Thorin [Vis alle 13 forfattere av denne artikkelen] (2019). Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma. Clinical and Experimental Immunology. ISSN 0009-9104. 197(1), s. 74–82. doi: 10.1111/cei.13283 Fulltekst i vitenarkiv
• Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R & Kvitting, John Peder Escobar [Vis alle 12 forfattere av denne artikkelen] (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects. Open heart. ISSN 2053-3624. 6.e001098(2), s. 1–8. doi: 10.1136/openhrt-2019-001098 Fulltekst i vitenarkiv
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus & Zhang, Lili [Vis alle 15 forfattere av denne artikkelen] (2019). NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology. ISSN 1664-3224. 10:1621(JULY), s. 1–13. doi: 10.3389/fimmu.2019.01621 Fulltekst i vitenarkiv
• Kontny, Frederic; Andersen, Thomas; Ueland, Thor; Åkerblom, Axel; Lakic, Tatevik G. & Michelsen, Annika [Vis alle 14 forfattere av denne artikkelen] (2019). Pentraxin-3 vs C-reactive Protein and Other Prognostic Biomarkers in Acute Coronary Syndrome: A Substudy of the Platelet Inhibition and Patients Outcomes (PLATO) Trial. European Heart Journal: Acute Cardiovascular Care. ISSN 2048-8726. 00(0), s. 1–10. doi: 10.1177/2048872619846334 Fulltekst i vitenarkiv
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C & Bertilson, Maria [Vis alle 15 forfattere av denne artikkelen] (2019). ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis. ISSN 0021-9150. s. 35–41. doi: 10.1016/j.atherosclerosis.2019.11.031 Fulltekst i vitenarkiv
• Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente & Munk, Peter Scott [Vis alle 9 forfattere av denne artikkelen] (2019). Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. s. 1–5. doi: 10.1177/2047487319855796 Fulltekst i vitenarkiv
• Abraityte, Judita Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James & McMurray, John J.V. [Vis alle 9 forfattere av denne artikkelen] (2019). T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clinical Research in Cardiology. ISSN 1861-0684. 108(2), s. 133–141. doi: 10.1007/s00392-018-1331-2 Fulltekst i vitenarkiv
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Vis alle 18 forfattere av denne artikkelen] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, s. 1–10. doi: 10.1038/s41598-018-35367-7 Fulltekst i vitenarkiv
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun & Hoseth, Eva Zsuzsanna [Vis alle 17 forfattere av denne artikkelen] (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine. ISSN 0033-2917. 49(10), s. 1749–1757. doi: 10.1017/S0033291718004142
• Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre & Kong, Xiang Yi [Vis alle 31 forfattere av denne artikkelen] (2019). Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages. Atherosclerosis. ISSN 0021-9150. s. 1–9. doi: 10.1016/j.atherosclerosis.2019.12.008 Fulltekst i vitenarkiv
• Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase & Surakka, Ida [Vis alle 23 forfattere av denne artikkelen] (2019). Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition. Circulation: Genomic and precision medicine. ISSN 2574-8300. 12(1). doi: 10.1161/CIRCGEN.118.002335 Fulltekst i vitenarkiv
• Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik & Berge, Rolf Kristian [Vis alle 14 forfattere av denne artikkelen] (2019). Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:9427, s. 1–10. doi: 10.1038/s41598-019-45861-1 Fulltekst i vitenarkiv
• Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Broch, Kaspar; Bendz, Bjørn & Aakhus, Svend [Vis alle 19 forfattere av denne artikkelen] (2019). Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI). Open heart. ISSN 2053-3624. 6(2), s. 1–9. doi: 10.1136/openhrt-2019-001108 Fulltekst i vitenarkiv
• Isaksen, Kjetil; Halvorsen, Bente; Munk, Peter Scott; Aukrust, Pål & Larsen, Alf Inge (2019). Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 53(4), s. 213–219. doi: 10.1080/14017431.2019.1629004 Fulltekst i vitenarkiv
• Holm, Sverre; Oma, Ingvild; Hagve, Tor-Arne; Saatvedt, Kjell; Brosstad, Frank Roger & Mikkelsen, Knut [Vis alle 13 forfattere av denne artikkelen] (2019). Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: A cross-sectional study. BMJ Open. ISSN 2044-6055. 9(5). doi: 10.1136/bmjopen-2019-030651 Fulltekst i vitenarkiv
• Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria & Aukrust, Pål [Vis alle 13 forfattere av denne artikkelen] (2019). C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 39(11), s. 2402–2410. doi: 10.1161/ATVBAHA.119.312633 Fulltekst i vitenarkiv
• Caidahl, Kenneth; Hartford, Martine Grinden; Ravn-Fischer, Annica; Lorentzen, Erik; Yndestad, Arne & Karlsson, Thomas [Vis alle 8 forfattere av denne artikkelen] (2019). Homeostatic Chemokines and Prognosis in Patients With Acute Coronary Syndromes. Journal of the American College of Cardiology. ISSN 0735-1097. 74(6), s. 774–782. doi: 10.1016/j.jacc.2019.06.030
• Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri & Hindberg, Kristian [Vis alle 10 forfattere av denne artikkelen] (2019). Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. s. 1–9. doi: 10.1111/jth.14539 Fulltekst i vitenarkiv
• Husebø, Gunnar; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena & D'Alessandro-Gabazza, Corina [Vis alle 10 forfattere av denne artikkelen] (2019). Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study. Respiratory Medicine. ISSN 0954-6111. 152, s. 81–88. doi: 10.1016/j.rmed.2019.04.019 Fulltekst i vitenarkiv
• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Ståle Haugset; Lauritzen, Trine & Oppen, Kjersti [Vis alle 11 forfattere av denne artikkelen] (2019). Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph. ISSN 2312-508X. 5(1). doi: 10.1183/23120541.00014-2019 Fulltekst i vitenarkiv
• Jørgensen, Silje Fjellgård; Fevang, Børre & Aukrust, Pål (2018). Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications. Journal of Clinical Immunology. ISSN 0271-9142. 39(1), s. 30–36. doi: 10.1007/s10875-018-0574-z
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde & Haanshuus, Christel Gill [Vis alle 10 forfattere av denne artikkelen] (2018). Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria. BMC Infectious Diseases. ISSN 1471-2334. 18. doi: 10.1186/s12879-018-3593-8 Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Ueland, Thor; Dyrhol-Riise, Anne Ma; Woll, Bjørn Martin; Holten, Aleksander Rygh; Pettersen, Frank O. & Lind, Andreas [Vis alle 10 forfattere av denne artikkelen] (2021). Increased inflammatory markers reflecting fibrogenesis are independently associated with cardiac involvement in hospitalized COVID-19 patients. Journal of Infection. ISSN 0163-4453. 82(5), s. 186–230. doi: 10.1016/j.jinf.2021.01.017
• Ishaq, Bushra; Aukrust, Pål; Diaz, Esperanza; Solbakk, Jan-Helge; Østby, Lars & Bjertness, Espen [Vis alle 8 forfattere av denne artikkelen] (2021). Vi trenger grundige analyser av den høye minoritetssmitten. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. s. 26–27.
• Ishaq, Bushra; Aukrust, Pål; Diaz, Esperanza; Solbakk, Jan-Helge; Østby, Lars & Tyssvang, Marius [Vis alle 7 forfattere av denne artikkelen] (2021). Det finnes ingen bevis for at kultur og religion er årsak til smitte. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. s. 33–33.
• Ueland, Thor; Holter, Jan Cato; Holten, Aleksander Rygh; Muller, Karl Erik; Lind, A. & Bekken, Gry Klouman [Vis alle 10 forfattere av denne artikkelen] (2020). Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure: MMP-9 and respiratory failure in COVID-19. Journal of Infection. ISSN 0163-4453. 81(3), s. e41–e43. doi: 10.1016/j.jinf.2020.06.061
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 9 forfattere av denne artikkelen] (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library . Vis sammendrag

  Introduction: The complement cascade is an important component of the innate immune system. Complement activation plays a major role in chronic inflammation and has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (C7) binds C5bC6 complex being part of the terminal complement complex (TCC/C5b-9). Purpose: To investigate the prognostic utility of complement C7 for long-term outcome in patients with suspected acute coronary syndrome (ACS). Methods: Complement C7 plasma-levels were measured by enzyme immunoassay in admission samples from 1823 patients included in a transatlantic prospective cohort study, which consecutively included hospital admitted chest-pain patients with clinically suspected ACS from South-Western Norway and Northern Argentina. Data were pooled for analysis. Univariable- and multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24 months, applying both quartiles (Q1-4) and loge-transformed continuous values of complement C7. Results: There were 253 (13.9%) deaths, of which 150 (8.2%) were categorized as cardiac death and 76 (4.2%) as SCD. Complement C7 levels were significantly higher in patients who died as compared to long-term survivors [176.9 (142.1 – 228.7) µg/mL versus 139.8 (110.6 – 179.7) µg/mL (median, 25 and 75% percentile), p < 0.001], and were significantly associated with 24-month survival [log rank p < 0.001 for all-cause mortality and cardiac death, log rank p = 0.035 for SCD]. In univariable analysis, patients with complement C7-concentrations in the highest quartiles had significantly increased risk of all-cause mortality (Figure 1), cardiac death [Q4: Hazard Ratio (HR) 4.58 (95% confidence interval (CI); 2.65 – 7.92), p < 0.001, Q3: HR 2.69 (95% CI; 1.51 – 4.80), p = 0.001] and SCD [Q4: HR 2.83 (95% CI; 1.36 – 5.90), p = 0.005, Q3: HR 2.33 (95% CI; 1.10 – 4.92), p = 0.027] compared to patients in the lowest quartile (Q1). After adjusting for conventional clinical risk factors for coronary heart disease, complement C7-concentrations in Q4 [HR 2.09 (95% CI; 1.23 – 3.57), p = 0.007] and Q3 [HR 2.21 (95% CI; 1.29 – 3.81), p = 0.004] remained significantly associated with all-cause mortality, reproduced using loge-transformed continuous values. Conclusion: High levels of complement C7 were found to independently predict long-term all-cause mortality in chest-pain patients with clinically suspected ACS.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 10 forfattere av denne artikkelen] (2020). Angiopoietin-like 4 protein is a long-term predictor of outcome in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library. Vis sammendrag

  Introduction: Angiopoietin-like 4 protein (ANGPTL4) has multiple physiological functions including modulation of angiogenesis, vascular permeability and lipid-metabolism. Acting as an inhibitor of lipoprotein lipase, ANGPTL4 has previously been found to be associated with lipid levels and risk of coronary artery disease. Purpose: To assess the prognostic value of ANGPTL4 for long-term outcome, in addition to conventional clinical risk factors, in chest-pain patients admitted with clinically suspected acute coronary syndrome (ACS). Methods: 1853 patients from Norway and Northern-Argentina were consecutively included in this prospective 2-center cohort study. ANGPTL4 concentrations were measured in 1829 admission-samples by enzyme immunoassay. Data were pooled for analysis. Multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-months, comparing event rates across ANGPTL4-quartiles (Q1-4). Of patients with suspected ACS, 845 had a troponin T (TnT) value above the detection-limit. Subgroup analysis was performed for all-cause mortality in patients stratified according to TnT release >/≤ 0.01 ng/mL. Results: During 24-months follow-up, 254 patients (13.9%) died, of which 150 (8.2%) suffered cardiac death and 76 (4.2%) SCD. Patients who died had significantly higher admission-levels of ANGPTL4 compared to long-term survivors [4.99 (3.54 – 8.37) ng/mL versus 3.18 (2.14 – 4.78) ng/mL (median, 25 and 75% percentiles), p < 0.001]. A stepwise increase in risk of all-cause death was seen with increasing quartiles of ANGPTL4, Figure 1. For cardiac death, ANGPTL4-levels in Q4 [Hazard Ratio (HR) 2.86 (95% confidence interval (CI); 1.10 – 7.45), p = 0.031] as compared to Q1 were found to be an independent predictor of outcome. Similar results were seen for SCD in adjusted analysis for ANGPTL4-Q4 [HR 7.37 (95% CI; 1.75 – 31.1), p = 0.007] as compared to Q1. In subgroup analysis, ANGPTL4 concentrations in the highest quartile were significantly associated with increased risk of all-cause mortality in patients with TnT-release [HR 2.07 (95% CI, 1.06 – 4.02), p = 0.032], but not in patients without TnT-release. Conclusion: High admission-levels of ANGPTL4 were found to be an independent long-term predictor of all-cause mortality, cardiac death and SCD in patients with suspected ACS.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 8 forfattere av denne artikkelen] (2020). Angiopoietin-2 is a long-term predictor of all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected acute coronary syndrome. Vis sammendrag

  Background: Angiopoietin-2 (ANGPT2) is an important regulator of angiogenesis. Higher levels of ANGPT2 have been found to be associated with an adverse cardiovascular risk factor profile potentially reflecting maladaptive vascular remodelling including atherosclerotic plaque destabilization. Purpose: To evaluate the prognostic utility of ANGPT2 added to conventional clinical risk factors for coronary heart disease, including B-type natriuretic peptide (BNP), troponin T (TnT) and C-reactive protein (CRP), in patients with suspected acute coronary syndrome (ACS). Methods: 871 chest-pain patients with clinically suspected ACS from South-Western Norway and 982 patients from Northern Argentina were consecutively included in a prospective transatlantic cohort study. We measured plasma-concentrations of ANGPT2 in admission-samples from 1815 patients by enzyme immunoassay. Univariable- and multivariable Cox proportional-hazards models, applying both loge-transformed continuous values and quartiles (Q1-4), were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-month follow-up. Of the patients with suspected ACS, 838 patients had TnT release above the detection-limit of 0.01 ng/mL. We performed subgroup analysis for all-cause mortality in patients with and without TnT release. Results: Median age in the total population was 66.0 (Q1-Q3; 55.0 – 76.8) years and 60.4% were males. At 24-month follow-up, 254 patients (14%) had died, of which 150 (8.3%) suffered cardiac death and 76 (4.2%) SCD. ANGPT2 levels were significantly higher in patients who died compared to long-term survivors [3.87 (2.40 – 7.54) ng/mL versus 2.11 (1.48 – 3.22) ng/mL (median, 25 and 75% percentiles), p < 0.001]. In multivariable analysis, ANGPT2 concentrations in the highest quartile (Q4) as compared to the lowest (Q1) were significantly associated with all-cause mortality [Hazard Ratio (HR) 1.96 (95% confidence interval (CI); 1.12 – 3.42), p = 0.018) and cardiac death [HR 2.23 (95% CI; 1.01 – 4.92), p = 0.047] at 24-month follow-up. For SCD, ANGPT2 concentrations in both Q3 [HR 3.59 (95% CI; 1.05 -12.3), p = 0.041] and Q4 [HR 3.81 (95% CI; 1.12 – 12.9), p = 0.032] as compared to Q1 were significantly related to outcome. These results were confirmed using loge-transformed continuous values of ANGPT2. ANGPT2 was also an independent predictor of all-cause mortality in both patients with and without TnT release. For patients with TnT > 0.01 ng/mL, HR for ANGPT2 in Q4 as compared to Q1 was 2.77 (95% CI; 1.41 – 5.44), p = 0.003. For patients with TnT ≤ 0.01, HR for ANGPT2-Q4 was 2.67 (95% CI; 1.08 – 6.62), p = 0.034. Conclusion: High levels of ANGPT2 were found to independently predict all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected ACS, irrespective of clinical demographics, troponin-release, CRP and BNP.

• Jørgensen, Silje Fjellgård; Holm, Kristian; Macpherson, Magnhild Eide; Larsen, Christopher Storm; Kummen, Martin & Fevang, Børre [Vis alle 8 forfattere av denne artikkelen] (2019). Selective IgA deficiency in humans is associated with reduced gut microbial diversity. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 143(5), s. 1969–1971.e11. doi: 10.1016/j.jaci.2019.01.019

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