Pål Aukrust

• Abraityte, Judita Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James; McMurray, John J.V.; van Veldhuisen, Dirk J.; Gullestad, Lars & Ueland, Thor (2019). T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clinical Research in Cardiology.  ISSN 1861-0684.  108(2), s 133- 141 . doi: 10.1007/s00392-018-1331-2 Fulltekst i vitenarkiv.
• Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta & Kontny, Frederic (2019). C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  39(11), s 2402- 2410 . doi: 10.1161/ATVBAHA.119.312633 Fulltekst i vitenarkiv.
• Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Broch, Kaspar; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Hopp, Einar; Kleveland, Ola; Stensæth, KnutT Haakon; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål & Gullestad, Lars (2019). Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI). Open heart.  ISSN 2053-3624.  6(2), s 1- 9 . doi: 10.1136/openhrt-2019-001108 Fulltekst i vitenarkiv.
• Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey & Åsvold, Bjørn Olav (2019). Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition. Circulation. Genomic and precision medicine.  ISSN 2574-8300.  12(1) . doi: 10.1161/CIRCGEN.118.002335 Fulltekst i vitenarkiv.
• Caidahl, Kenneth; Hartford, Martine Grinden; Ravn-Fischer, Annica; Lorentzen, Erik; Yndestad, Arne; Karlsson, Thomas; Aukrust, Pål & Ueland, Thor (2019). Homeostatic Chemokines and Prognosis in Patients With Acute Coronary Syndromes. Journal of the American College of Cardiology.  ISSN 0735-1097.  74(6), s 774- 782 . doi: 10.1016/j.jacc.2019.06.030
• Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore; Bollerslev, Jens; Espevik, Terje; Aukrust, Pål; Halvorsen, Bente & Holven, Kirsten Bjørklund (2019). Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children. Molecular Nutrition & Food Research.  ISSN 1613-4125.  63(7) . doi: 10.1002/mnfr.201800990 Fulltekst i vitenarkiv.
• Dimopoulou, Chrysoula; Lundgren, Jens D.; Sundal, Jon; Ullum, Henrik; Aukrust, Pål; Nielsen, Finn C. & Marvig, Rasmus L. (2019). Variant in ERAP1 promoter region is associated with low expression in a patient with a Behcet-like MHC-I-opathy. Journal of Human Genetics.  ISSN 1434-5161.  65, s 325- 335 . doi: 10.1038/s10038-019-0709-y
• Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H.; Sagen, Ellen; Michelsen, Annika; Vinge, Leif Erik; Øie, Erik; Gullestad, Lars; Halvorsen, Bente; Hansen, Trond Vidar; Aukrust, Pål; Dalli, Jesmond & Yndestad, Arne (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine.  ISSN 2352-3964.  46, s 264- 273 . doi: 10.1016/j.ebiom.2019.07.024
• Gregersen, Ida; Høibraaten, Else; Holven, Kirsten Bjørklund; Løvdahl, Lene; Ueland, Thor; Mowinckel, Marie-Christine; Dahl, Tuva Børresdatter; Aukrust, Pål; Halvorsen, Bente & Sandset, Per Morten (2019). Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women. Thrombosis Research.  ISSN 0049-3848.  184, s 1- 7 . doi: 10.1016/j.thromres.2019.10.005
• Holm, Sverre; Oma, Ingvild; Hagve, Tor-Arne; Saatvedt, Kjell; Brosstad, Frank Roger; Mikkelsen, Knut; Rydningen, Hans; Risnes, Ivar; Almdahl, Sven Martin; Ueland, Thor; Aukrust, Pål; Halvorsen, Bente & Hollan, Ivana (2019). Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: A cross-sectional study. BMJ Open.  ISSN 2044-6055.  9(5) . doi: 10.1136/bmjopen-2019-030651 Fulltekst i vitenarkiv.
• Holt, Margrethe Flesvig; Seim, Bjørn Edvard; Øgaard, Jonas; Olsen, Maria Belland; Woldbæk, Per R; Kvitting, John Peder Escobar; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom Eirik; Nilsson, Per; Louwe, Maria Cornelia & Ranheim, Trine (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: A dysregulation with potential inflammatory effects. Open heart.  ISSN 2053-3624.  6.e001098(2), s 1- 8 . doi: 10.1136/openhrt-2019-001098 Fulltekst i vitenarkiv.
• Husebø, Gunnar; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pål & Eagan, Tomas Mikal (2019). Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study. Respiratory Medicine.  ISSN 0954-6111.  152, s 81- 88 . doi: 10.1016/j.rmed.2019.04.019
• Isaksen, Kjetil; Halvorsen, Bente; Munk, Peter Scott; Aukrust, Pål & Larsen, Alf Inge (2019). Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  53(4), s 213- 219 . doi: 10.1080/14017431.2019.1629004
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund & Fevang, Børre (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports.  ISSN 2045-2322.  9:167, s 1- 10 . doi: 10.1038/s41598-018-35367-7 Fulltekst i vitenarkiv.
• Kontny, Frederic; Andersen, Thomas; Ueland, Thor; Åkerblom, Axel; Lakic, Tatevik G.; Michelsen, Annika; Aukrust, Pål; Bertilsson, Maria; Becker, Richard C.; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F. & Wallentin, Lars (2019). Pentraxin-3 vs C-reactive Protein and Other Prognostic Biomarkers in Acute Coronary Syndrome: A Substudy of the Platelet Inhibition and Patients Outcomes (PLATO) Trial.. European heart journal. Acute cardiovascular care..  ISSN 2048-8726.  00(0), s 1- 10 . doi: 10.1177/2048872619846334
• Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente; Munk, Peter Scott; Kvaløy, Jan Terje; Aukrust, Pål & Yndestad, Arne (2019). Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy. European Journal of Preventive Cardiology.  ISSN 2047-4873.  s 1- 5 . doi: 10.1177/2047487319855796 Fulltekst i vitenarkiv.
• Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik & Hansen, John-Bjarne (2019). Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  s 1- 9 . doi: 10.1111/jth.14539 Fulltekst i vitenarkiv.
• Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein & Halvorsen, Bente (2019). Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages. Atherosclerosis.  ISSN 0021-9150.  s 1- 9 . doi: 10.1016/j.atherosclerosis.2019.12.008
• Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre & Jørgensen, Silje Fjellgård (2019). Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency. Scientific Reports.  ISSN 2045-2322.  9:9427, s 1- 10 . doi: 10.1038/s41598-019-45861-1 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine.  ISSN 0033-2917.  49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Vis sammendrag

  Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role

• Narverud, Ingunn; Bogsrud, Martin Prøven; Øyri, Linn Kristin Lie; Ulven, Stine Marie; Retterstøl, Kjetil; Ueland, Thor; Mulder, Monique; van Lennep, Jeanine Roeters; Halvorsen, Bente; Aukrust, Pål; Veierød, Marit Bragelien & Holven, Kirsten Bjørklund (2019). Lipoprotein (a) concentration is associated with plasma arachidonic acid in subjects with familial hypercholesterolemia. British Journal of Nutrition.  ISSN 0007-1145. . doi: 10.1017/S0007114519001600
• Narverud, Ingunn; Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda; Aukrust, Pål; Espevik, Terje; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Ueland, Thor; Halvorsen, Bente & Holven, Kirsten Bjørklund (2019). Profiling of immune-related gene expression in children with familial hypercholesterolaemia. Journal of Internal Medicine.  ISSN 0954-6820.  s 1- 12 . doi: 10.1111/joim.13001 Fulltekst i vitenarkiv.
• Nome, Marianne Eikhom; Euceda, Leslie R.; Jabeen, Shakila; Debik, Julia; Bathen, Tone Frost; Giskeødegård, Guro F.; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Halvorsen, Bente; Yndestad, Arne; Borgen, Elin; Garred, Øystein; Aukrust, Pål; Ueland, Thor; Engebråten, Olav; Kristensen, Vessela N. & Tekpli, Xavier (2019). Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers. International Journal of Cancer.  ISSN 0020-7136.  146(1), s 223- 235 . doi: 10.1002/ijc.32638 Fulltekst i vitenarkiv.
• Nyakas, Marta Sølvi; Aamdal, Elin; Jacobsen, Kari Dolven; Guren, Tormod Kyrre; Aamdal, Steinar; Hagene, Kirsten Thorin; Brunsvig, Paal Fr.; Yndestad, Arne; Halvorsen, Bente; Tasken, Kristin Austlid; Aukrust, Pål; Mælandsmo, Gunhild Mari & Ueland, Thor (2019). Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma. Clinical and Experimental Immunology.  ISSN 0009-9104.  197(1), s 74- 82 . doi: 10.1111/cei.13283 Fulltekst i vitenarkiv.
• Quist-Paulsen, Else; Ormaasen, Vidar; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ueland, Per Magne; Ueland, Thor; Eikeland, Randi; Aukrust, Pål & Nordenmark, Tonje Haug (2019). Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning. Scientific Reports.  ISSN 2045-2322.  9 . doi: 10.1038/s41598-019-52570-2 Fulltekst i vitenarkiv.
• Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K; Hussain, Amjad Iqbal; Pettersen, Kjell; Aakhus, Svend; Espeland, Torvald; Lunde, Ida Gjervold; Kirschfink, Michael; Nilsson, Per; Mollnes, Tom Eirik; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne & Louwe, Maria Cornelia (2019). Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis. Journal of Immunology.  ISSN 0022-1767.  203(7), s 1973- 1980 . doi: 10.4049/jimmunol.1801244
• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Ståle Haugset; Lauritzen, Trine; Oppen, Kjersti; Husebye, Einar; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2019). Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph.  ISSN 2312-508X.  5(1) . doi: 10.1183/23120541.00014-2019 Fulltekst i vitenarkiv.
• Sokolova, Marina; Ranheim, Trine; Louwe, Maria Cornelia; Halvorsen, Bente; Yndestad, Arne & Aukrust, Pål (2019). NLRP3 inflammasome: A novel player in metabolically induced inflammation-potential influence on the myocardium. Journal of Cardiovascular Pharmacology.  ISSN 0160-2446.  74(4), s 276- 284 . doi: 10.1097/FJC.0000000000000704
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2019). NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology.  ISSN 1664-3224.  10:1621(JULY), s 1- 13 . doi: 10.3389/fimmu.2019.01621 Fulltekst i vitenarkiv.
• Solberg, Ole Geir; Stavem, Knut; Ragnarsson, Asgrimur; Beitnes, Jan Otto; Skårdal, Rita; Seljeflot, Ingebjørg; Ueland, Thor; Aukrust, Pål; Gullestad, Lars & Aaberge, Lars (2019). Index of microvascular resistance to assess the effect of rosuvastatin on microvascular function in women with chest pain and no obstructive coronary artery disease: A double-blind randomized study. Catheterization and cardiovascular interventions.  ISSN 1522-1946.  94(5), s 660- 668 . doi: 10.1002/ccd.28157 Fulltekst i vitenarkiv.
• Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine; Vinge, Leif Erik; Aukrust, Pål; Stensløkken, Kåre-Olav; Yndestad, Arne & Sandanger, Øystein (2019). Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts. Frontiers in Immunology.  ISSN 1664-3224.  10 . doi: 10.3389/fimmu.2019.01285 Fulltekst i vitenarkiv.
• Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål & Ueland, Thor (2019). The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection. The Journal of Heart and Lung Transplantation.  ISSN 1053-2498.  38(10), s 1097- 1103 . doi: 10.1016/j.healun.2019.06.003 Fulltekst i vitenarkiv.
• Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein; Bendiksen, Bård Andre; Espe, Emil Knut Stenersen; Sjaastad, Ivar; Løberg, Else Marit; Yndestad, Arne; Aukrust, Pål; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  316(6), s L999- L1012 . doi: 10.1152/ajplung.00322.2018
• Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews.  ISSN 1520-7552.  :e3114, s 1- 9 . doi: 10.1002/dmrr.3114 Fulltekst i vitenarkiv.
• Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X. . doi: 10.1210/clinem/dgz119 Fulltekst i vitenarkiv.
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål & Wallentin, Lars (2019). Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  39(2), s 294- 302 . doi: 10.1161/ATVBAHA.118.311042
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C; Bertilson, Maria; Budaj, Andrzej; Cornel, Jan H; Himmelmann, Anders; James, Stefan K; Siegbahn, Agneta; Storey, Robert F; Kontny, Frederic; Aukrust, Pål & Wallentin, Lars (2019). ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis.  ISSN 0021-9150.  s 35- 41 . doi: 10.1016/j.atherosclerosis.2019.11.031 Vis sammendrag

  Background and aims: Activated leukocyte cell adhesion molecule (ALCAM) is upregulated during inflammation and involved in transmigration of leukocytes and T-cell activation. We hypothesized that ALCAM might be associated with recurrent events in patients with acute coronary syndromes (ACS). Methods: ALCAM was measured in serum obtained on admission, at discharge, 1 month and 6 months in a subgroup of 5165 patients admitted with ACS and included in the PLATelet inhibition and patient Outcomes (PLATO) trial (NCT00391872). The association between ALCAM and the composite endpoint and its components, including cardiovascular (CV) death, non-procedural spontaneous myocardial infarction (MI) or stroke during 1-year follow-up, was assessed by Cox proportional hazards models with incremental addition of clinical risk factors and biomarkers (including high-sensitivity troponin T, N-terminal pro−B-type natriuretic peptide and growth differentiation factor-15). Results: The median (Q1-Q3) concentration of ALCAM at admission was 97 (80–116) ng/mL. A 50% higher level of ALCAM on admission was associated with a hazard ratio (HR) of 1.16 (95% confidence interval [1.00–1.34] p=0.043) for the composite endpoint in fully adjusted analysis, mainly driven by the association with CV death (HR 1.45 [1.16–1.82] p = 0.0012). Conclusions: In patients with ACS, admission level of ALCAM was independently associated with adverse outcome including CV death even after adjustment for established inflammatory and cardiac biomarkers.

• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag; Reponen, Elina Johanna; Lyngstad, Siv Hege; Lekva, Tove; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas; Agartz, Ingrid & Myhre, Anne Margrethe (2019). Increased Interleukin 18 Activity in Adolescents With Early-Onset Psychosis Is Associated With Cortisol and Depressive Symptoms. Psychoneuroendocrinology.  ISSN 0306-4530.  112 (2020)(104513) . doi: 10.1016/j.psyneuen.2019.104513 Fulltekst i vitenarkiv.
• Yang, Kuan; Lauritzen, Knut Husø; Olsen, Maria Belland; Dahl, Tuva Børresdatter; Ranheim, Trine; Ahmed, Muhammad Shakil; Attramadal, Håvard; Aukrust, Pål; Halvorsen, Bente; Nyman, Tuula Anneli; Sandanger, Øystein & Yndestad, Arne (2019). Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes. Journal of Immunology.  ISSN 0022-1767.  203(6), s 1598- 1608 . doi: 10.4049/jimmunol.1801382
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Fulltekst i vitenarkiv.
• Abadpour, Shadab; Halvorsen, Bente; Sahraoui, Afaf; Korsgren, Olle; Aukrust, Pål & Scholz, Hanne (2018). Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT. Journal of Molecular Endocrinology.  ISSN 0952-5041.  60(3), s 171- 183 . doi: 10.1530/JME-17-0182
• Arora, Satish; Andreassen, Arne K.; Karason, Kristjan; Gustafsson, Finn; Eiskjær, Hans; Bøtker, Hans Erik; Rådegran, Göran; Gude, Einar; Ioanes, Dan; Solbu, Dag; Dellgren, Göran; Ueland, Thor; Aukrust, Pål & Gullestad, Lars (2018). Effect of everolimus initiation and calcineurin inhibitor elimination on cardiac allograft vasculopathy in de novo heart transplant recipients. Circulation: Heart Failure.  ISSN 1941-3289.  11:e004050(9) . doi: 10.1161/CIRCHEARTFAILURE.117.004050 Fulltekst i vitenarkiv.
• Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Yndestad, Arne; Halvorsen, Bente; Brustugun, Odd Terje; Aukrust, Pål; Ueland, Thor & Helland, Åslaug (2018). Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease. BMC Cancer.  ISSN 1471-2407.  18(1) . doi: 10.1186/s12885-018-4659-0
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139, s 37- 45 . doi: 10.1111/acps.12971
• Ellingsen, Trygve; Lappegård, Jostein; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas & Hansen, John-Bjarne (2018). Plasma hepcidin is associated with future risk of venous thromboembolism. Blood Advances.  ISSN 2473-9529.  2(11), s 1191- 1197 . doi: 10.1182/bloodadvances.2018018465 Fulltekst i vitenarkiv.
• Heldal, Torbjørn Fossum; Ueland, Thor; Jenssen, Trond Geir; Hartmann, Anders; Reisæter, Anna Varberg; Aukrust, Pål; Michelsen, Annika & Åsberg, Anders (2018). Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study. Transplant International.  ISSN 0934-0874.  31(5), s 510- 519 . doi: 10.1111/tri.13116
• Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam & Trøseid, Marius (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-25168-3 Fulltekst i vitenarkiv.
• Hoffmann-Vold, Anna-Maria; Hesselstrand, Roger; Fretheim, Håvard Halland; Ueland, Thor; Andreassen, Arne K.; Brunborg, Cathrine; Palchevskiy, Vyacheslav; Midtvedt, Øyvind; Garen, Torhild Oddveig; Aukrust, Pål; Belperio, John A & Molberg, Øyvind (2018). CCL21 as a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis & Rheumatology.  ISSN 2326-5191.  70(10), s 1644- 1653 . doi: 10.1002/art.40534
• Hoffmann-Vold, Anna-Maria; Weigt, Stefan; Palchevskiy, Vyacheslav; Volkmann, Elizabeth R.; Saggar, Rajan; Li, Ning; Midtvedt, Øyvind; Lund, May-Brith; Garen, Torhild Oddveig; Fishbein, Michael C; Ardehali, Abbas; Ross, David J.; Ueland, Thor; Aukrust, Pål; Lynch, Joseph P; Elashoff, Robert M.; Molberg, Øyvind & Belperio, John A (2018). Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis. PLOS ONE.  ISSN 1932-6203.  13(11), s 1- 15 . doi: 10.1371/journal.pone.0206545 Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Fulltekst i vitenarkiv.
• Jørgensen, Silje Fjellgård; Fevang, Børre & Aukrust, Pål (2018). Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications. Journal of Clinical Immunology.  ISSN 0271-9142.  39(1), s 30- 36 . doi: 10.1007/s10875-018-0574-z
• Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Melberg, Tor Harald; Skadberg, Øyvind; Bergseth, Rolf; Selvåg, Jone; Auestad, Bjørn Henrik; Aukrust, Pål; Aarsland, Torbjørn & Ørn, Stein (2018). High physical fitness is associated with reduction in basal and exercise induced inflammation. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  28(1), s 172- 179 . doi: 10.1111/sms.12878
• Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål & Damås, Jan Kristian (2018). Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  271, s 1- 7 . doi: 10.1016/j.ijcard.2018.04.136 Fulltekst i vitenarkiv.
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Ueland, Thor; Michelsen, Annika; Pettersen, Kjell; Aukrust, Pål; Mørkrid, Lars; Gullestad, Lars & Broch, Kaspar (2018). Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis. Open heart.  ISSN 2053-3624.  5:e000901(2), s 1- 10 . doi: 10.1136/openhrt-2018-000901 Fulltekst i vitenarkiv.
• Lekva, Tove; Godang, Kristin; Michelsen, Annika; Qvigstad, Elisabeth; Normann, Kjersti Ringvoll; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Roland, Marie Cecilie & Ueland, Thor (2018). Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation. Scientific Reports.  ISSN 2045-2322.  8:13392, s 1- 9 . doi: 10.1038/s41598-018-31614-z Fulltekst i vitenarkiv.
• Mayerhofer, Christiane Caroline; Awoyemi, Ayodeji Olawale; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund; Aukrust, Pål; Hovland, Anders; Lorenzo, Andrea; Halvorsen, Sigrun; Seljeflot, Ingebjørg; Gullestad, Lars; Trøseid, Marius & Broch, Kaspar (2018). Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial. ESC Heart Failure.  ISSN 2055-5822.  5, s 978- 985 . doi: 10.1002/ehf2.12332 Fulltekst i vitenarkiv.
• Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari; Olsen, Maria Belland; Kong, Xiang Yi; Gude, Einar; Andreassen, Arne K.; Solbu, Dag; Karason, Kristjan; Dellgren, Göran; Gullestad, Lars; Aukrust, Pål & Ueland, Thor (2018). Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression. American Journal of Transplantation.  ISSN 1600-6135.  s 1- 11 . doi: 10.1111/ajt.15141 Fulltekst i vitenarkiv. Vis sammendrag

  Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1.

• Nymo, Ståle Haugset; Hartford, Marianne; Ueland, Thor; Yndestad, Arne; Lorentzen, Erik; Truvé, Katarina; Karlsson, Thomas; Ravn-Fischer, Annica; Aukrust, Pål & Caidahl, Kenneth (2018). Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome. International Journal of Cardiology.  ISSN 0167-5273.  262, s 79- 84 . doi: 10.1016/j.ijcard.2018.03.028 Fulltekst i vitenarkiv.
• Oma, Ingvild; Olstad, Ole Kristoffer; Andersen, Jacqueline Kirsti; Lyberg, Torstein; Molberg, Øyvind; Fostad, Ida; Fagerland, Morten; Almdahl, Sven Martin; Rynning, Stein Erik; Yndestad, Arne; Aukrust, Pål; Whist, Jon Elling & Hollan, Ivana (2018). Differential expression of Vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis. PLOS ONE.  ISSN 1932-6203.  13:e0202346(8), s 1- 13 . doi: 10.1371/journal.pone.0202346 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve Guttorm; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Øystein; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock. ESC Heart Failure.  ISSN 2055-5822.  5(3), s 292- 301 . doi: 10.1002/ehf2.12266 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.02035 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Shetelig, Christian; Ueland, Thor; Limalanathan, Shanmuganathan; Nilsson, Per; Husebye, Trygve Guttorm; Aukrust, Pål; Seljeflot, Ingebjørg; HOFFMANN, PAVEL; Eritsland, Jan; Mollnes, Tom Eirik; Andersen, Geir Øystein & Yndestad, Arne (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  268, s 187- 192 . doi: 10.1016/j.ijcard.2018.05.032 Fulltekst i vitenarkiv.
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Fevang, Børre; Aukrust, Pål; Langeland, Nina & Ueland, Thor (2018). Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria. BMC Infectious Diseases.  ISSN 1471-2334.  18 . doi: 10.1186/s12879-018-3593-8 Fulltekst i vitenarkiv. Vis sammendrag

  BACKGROUND: The immune response during P. falciparum infection is a two-edged sword, involving dysregulation of the inflammatory responses with several types of immune cells participating. Here we examined T-cell, monocyte/macrophage and neutrophil activation during P. falciparum infection by using soluble activation markers for these leukocyte subsets. METHODS: In a prospective cross-sectional study clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) co-infection with HIV-1, as well as HIV-infected patients with similar symptoms but without malaria (n = 58) and healthy controls (n = 52). Soluble (s)CD25, sCD14, sCD163 and myeloperoxidase (MPO) as markers for T-cell, monocyte/macrophage and neutrophil activation, respectively as well as CX3CL1, granzyme B and TIM-3 as markers of T-cell subsets and T-cell exhaustion, were analyzed. RESULTS: All patient groups had raised levels of activation markers compared with healthy controls. Levels of sCD25 and MPO increased gradually from patient with HIV only to patient with malaria only, with the highest levels in the HIV/malaria group. In the malaria group as a whole, MPO, sCD14 and in particular sCD25 were correlated with disease severity. sCD163, sCD25 and in particular MPO correlated with the degree of parasitemia as assessed by qPCR. Patients with falciparum malaria also had signs of T-cell subset activation (i.e. increased granzyme B and CX3CL1) and T-cell exhaustion as assessed by high levels of TIM-3 particularly in patients co-infected with HIV. CONCLUSION: Our data support a marked immune activation in falciparum malaria involving all major leukocyte subsets with particular enhanced activation of neutrophils and T-cells in patients co-infected with HIV. Our findings also support a link between immune activation and immune exhaustion during falciparum malaria, particularly in relation to T-cell responses in patients co-infected with HIV

• Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik & Dyrhol-Riise, Anne Ma (2018). High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections. Journal of Neuroinflammation.  ISSN 1742-2094.  15(327) . doi: 10.1186/s12974-018-1366-3 Fulltekst i vitenarkiv.
• Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2018). Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia. Open Forum Infectious Diseases.  ISSN 2328-8957.  5(2) . doi: 10.1093/ofid/ofy002 Fulltekst i vitenarkiv.
• Skarpengland, Tonje; Skjelland, Mona; Kong, Xiang Yi; Skagen, Karolina Ryeng; Holm, Sverre; Otterdal, Kari; Dahl, Christen Peder; Krohg-Sørensen, Kirsten; Sagen, Ellen Lund; Bjerkeli, Vigdis; Aamodt, Anne Hege; Abbas, Azhar; Gregersen, Ida; Aukrust, Pål; Halvorsen, Bente & Dahl, Tuva Børresdatter (2018). Increased levels of lectin-like oxidized low-density lipoprotein receptor-1 in ischemic stroke and transient ischemic attack. Journal of the American Heart Association.  ISSN 2047-9980.  7:e006479(2), s 1- 16 . doi: 10.1161/JAHA.117.006479 Fulltekst i vitenarkiv.
• Sokolova, Marina; Sahraoui, Afaf; Høyem, Merete; Øgaard, Jonas; Lien, Egil; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine & Scholz, Hanne (2018). NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  315(5), s E912- E923 . doi: 10.1152/ajpendo.00461.2017
• Steineger, Johan Edvard; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Osnes, Terje; Heimdal, Ketil Riddervold & Dheyauldeen, Sinan (2018). Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis. The Laryngoscope.  ISSN 0023-852X.  129(1), s E44- E49 . doi: 10.1002/lary.27548
• Traaen, Gunn Marit; Aakerøy, Lars; Hunt, Tove Elisabeth F.; Øverland, Britt; Lyseggen, Erik; Aukrust, Pål; Ueland, Thor; Helle-Valle, Thomas Michael; Steinshamn, Sigurd Loe; Edvardsen, Thor; Zare, Hasse Khiabani; Aakhus, Svend; Akre, Harriet; Anfinsen, Ole-Gunnar; Loennechen, Jan Pål & Gullestad, Lars (2018). Treatment of sleep apnea in patients with paroxysmal atrial fibrillation: design and rationale of a randomized controlled trial. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  52(6), s 372- 377 . doi: 10.1080/14017431.2019.1567933
• Trøseid, Marius; Nordøy, Ingvild; Fevang, Børre & Aukrust, Pål (2018). Anbud på hivlegemidler er ikke faglig begrunnet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(20), s 1- 3 . doi: 10.4045/tidsskr.18.0808
• Ueland, Thor; Gullestad, Lars; Kou, Lei; Aukrust, Pål; Anand, Inder S.; Nordlund, Marianne Sparby; McMurray, John J.; van Veldhuisen, Dirk J.; Warren, David & Bolstad, Nils (2018). Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study. ESC Heart Failure.  ISSN 2055-5822.  s 1- 8 . doi: 10.1002/ehf2.12312 Fulltekst i vitenarkiv.
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente & Yndestad, Arne (2018). Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction. Open heart.  ISSN 2053-3624.  5(2) . doi: 10.1136/openhrt-2017-000765 Fulltekst i vitenarkiv.
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne & Halvorsen, Bente (2018). Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  274, s 348- 350 . doi: 10.1016/j.ijcard.2018.06.093
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic & Wallentin, Lars (2018). Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American Heart Association.  ISSN 2047-9980.  7(2) . doi: 10.1161/JAHA.117.007009 Fulltekst i vitenarkiv.
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Fulltekst i vitenarkiv.
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar & Ueland, Thor (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-03625-9 Fulltekst i vitenarkiv.
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika; Ranheim, Trine; Alfsnes, Katrine; Fiane, Arnt E; Aakhus, Svend; Lunde, Ida Gjervold; Dahl, Christen Peder; Aukrust, Pål; Christensen, Geir Arve; Gullestad, Lars; Yndestad, Arne & Ueland, Thor (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine.  ISSN 0946-2716.  95(7), s 767- 777 . doi: 10.1007/s00109-017-1529-1
• Auensen, Andreas; Hussain, Amjad; Falk, Ragnhild Sørum; Walle-Hansen, Marte Meyer; Bye, Jorun Merete; Pettersen, Kjell; Aukrust, Pål; Ueland, Thor & Gullestad, Lars (2017). Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis. PLOS ONE.  ISSN 1932-6203.  12:e0179304(6), s 1- 14 . doi: 10.1371/journal.pone.0179304 Fulltekst i vitenarkiv.
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.. Journal of Immunology.  ISSN 0022-1767.  199(8), s 2910- 2920 . doi: 10.4049/jimmunol.1700302 Fulltekst i vitenarkiv. Vis sammendrag

  Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect on CC via suppression of the inflammasome and liver X receptor activation. The putative effects of BCD on CC-induced complement activation remain unknown. In this study, we found that BCD bound to CC and reduced deposition of Igs, pattern recognition molecules, and complement factors on CC in human plasma. Furthermore, BCD decreased complement activation as measured by terminal complement complex and lowered the expression of complement receptors on monocytes in whole blood in response to CC exposure. In line with this, BCD also reduced reactive oxygen species formation caused by CC in whole blood. Furthermore, BCD attenuated the CC-induced proinflammatory cytokine responses (e.g., IL-1α, MIP-1α, TNF, IL-6, and IL-8) as well as regulated a range of CC-induced genes in human PBMC. BCD also regulated complement-related genes in human carotid plaques treated ex vivo. Formation of terminal complement complex on other complement-activating structures such as monosodium urate crystals and zymosan was not affected by BCD. These data demonstrate that BCD inhibits CC-induced inflammatory responses, which may be explained by BCD-mediated attenuation of complement activation. Thus, these findings support the potential for using BCD in treatment of atherosclerosis.

• Bermudez, Beatriz; Dahl, Tuva Børresdatter; Medina, Indira; Groeneweg, Mathijs; Holm, Sverre; Montserrat-De La Paz, Sergio; Rousch, Mat; Otten, Jeroen; Hérias, Veronica; Varela, Lourdes M.; Ranheim, Trine; Yndestad, Arne; Ortega-Gomez, Almudena; Abia, Rocio; Nagy, Laszlo; Aukrust, Pål; Muriana, Francisco J.G.; Halvorsen, Bente & Biessen, Erik Anna Leonardus (2017). Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPARγ-dependent monocyte differentiation and function. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  37(6), s 1157- 1167 . doi: 10.1161/ATVBAHA.116.308187
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia. Atherosclerosis.  ISSN 0021-9150.  256 . doi: 10.1016/j.atherosclerosis.2016.11.031
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Data on circulating leukocyte subpopulations and inflammatory proteins in children with familial hypercholesterolemia and healthy children. Data in Brief.  ISSN 2352-3409.  10, s 587- 592 . doi: 10.1016/j.dib.2016.12.042
• Christensen, Jacob J.; Ulven, Stine Marie; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin Prøven; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study. Atherosclerosis.  ISSN 0021-9150.  266, s 48- 57 . doi: 10.1016/j.atherosclerosis.2017.09.021
• Dhondup, Yangchen; Sjaastad, Ivar; Sandanger, Øystein; Aronsen, Jan Magnus; Ahmed, Muhammad Shakil; Attramadal, Håvard; Finsen, Alexandra; Zhang, Lili; Ranheim, Trine; Alfsnes, Katrine; Aukrust, Pål; Christensen, Geir Arve; Yndestad, Arne & Vinge, Leif Erik (2017). Toll-like receptor 9 promotes survival in SERCA2a KO heart failure mice. Mediators of Inflammation.  ISSN 0962-9351.  2017:9450439, s 1- 11 . doi: 10.1155/2017/9450439 Fulltekst i vitenarkiv.
• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Bjerve, Kristian S; Michelsen, Annika; Aukrust, Pål; Schmidt, EB; Christensen, JH & Jenssen, Trond Geir (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition.  ISSN 1051-2276.  27(3), s 161- 168 . doi: 10.1053/j.jrn.2016.09.008 Vis sammendrag

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Gregersen, Ida; Sandanger, Øystein; Askevold, Erik Tandberg; Sagen, Ellen Lund; Yang, Kuan; Holm, Sverre; Pedersen, Turid Margrethe; Skjelland, Mona; Krohg-Sørensen, Kirsten; Hansen, Trond Vidar; Dahl, Tuva Børresdatter; Otterdal, Kari; Espevik, Terje; Aukrust, Pål; Yndestad, Arne & Halvorsen, Bente (2017). Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.. PLOS ONE.  ISSN 1932-6203.  12(11) . doi: 10.1371/journal.pone.0188387 Fulltekst i vitenarkiv.
• Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge; Ivanauskiene, Kristina; Collas, Philippe; Shaposhnikov, Sergey; Collins, Andrew Richard; Indrevær, Randi Larsen; Aukrust, Pål; Fevang, Børre & Blomhoff, Heidi Kiil (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLOS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185708 Fulltekst i vitenarkiv.

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• Jørgensen, Silje Fjellgård; Holm, Kristian; Macpherson, Magnhild Eide; Larsen, Christopher Storm; Kummen, Martin; Fevang, Børre; Aukrust, Pål & Hov, Johannes Espolin Roksund (2019). Selective IgA deficiency in humans is associated with reduced gut microbial diversity. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  143(5), s 1969- 1971.e11 . doi: 10.1016/j.jaci.2019.01.019
• Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore; Bollerslev, Jens; Espevik, Terje; Aukrust, Pål; Halvorsen, Bente & Holven, Kirsten Bjørklund (2018). Association between omega 6 fatty acids and inflammation-related gene expression in PBMCs: a cross-sectional study in healthy children.
• Fevang, Børre; Fagerli, Unn Merete; Sorte, Hanne Sørmo; Aarset, Harald; Hov, Håkon; Langmyr, Marit; Keil, Thomas; Bjørge, Ellen; Aukrust, Pål; Stray-Pedersen, Asbjørg & Gedde-Dahl, Thobias (2018). Runaway Train; A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas. Hindawi (Case Reports in Immunology). . doi: 10.1155/2018/2053716
• Sikkeland, Liv Ingunn Bjoner; Borander, Anne Katrine; Voie, Øyvind Albert; Aass, Hans Christian Dalsbotten; Øvstebø, Reidun; Aukrust, Pål; Longva, Kjetil Sager; Alexis, Neil E.; Kongerud, Johny & Ueland, Thor (2018). Systemic and Airway Inflammation After Exposure to Fumes from Military Small Arms. American Journal of Respiratory and Critical Care Medicine.  ISSN 1073-449X.  197(10), s 1349- 1353 . doi: 10.1164/rccm.201709-1857LE
• Udjus, Camilla; Cero, Fadila; Halvorsen, Bente; Aukrust, Pål; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2018). Inhibition of caspase-1 reduces hypoxia-induced pulmonary hypertension by downregulating smooth muscle cell growth.
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin inhibits CC-induced complement activation.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten B. (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Ulven, Stine M.; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin P.; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study.
• Espevik, Terje; Niyonzima, Nathalie; Bakke, Siril Skaret; Halvorsen, Bente; Gregersen, Ida; Skjelland, Mona; Yndestad, Arne; Sandanger, Øystein; Andersen, Geir Øystein; Gullestad, Lars; Latz, Eicke; Aukrust, Pål & Mollnes, Tom Eirik (2017). Systemic- and local complement activation controls the NLRP3 inflammasome pathway in patients with atherosclerosis.

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