Pål Aukrust

• Lekva, Tove; Ueland, Thor; Halvorsen, Bente; Murphy, Sarah Louise Mikalsen; Dyrhol-Riise, Anne Ma & Tveita, Anders Aune [Vis alle 14 forfattere av denne artikkelen] (2022). Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection. Infectious Diseases. ISSN 2374-4235. 54(12), s. 918–923. doi: 10.1080/23744235.2022.2113135. Fulltekst i vitenarkiv
• Lee-Ødegård, Sindre; Ueland, Thor; Thorsby, Per Medbøe; Aukrust, Pål; Michelsen, Annika Elisabet & Halvorsen, Bente [Vis alle 8 forfattere av denne artikkelen] (2022). Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes. BMC Endocrine Disorders. ISSN 1472-6823. 22(1). doi: 10.1186/s12902-022-01127-y. Fulltekst i vitenarkiv
• Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar & Woxholt, Sindre [Vis alle 29 forfattere av denne artikkelen] (2022). Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial. EBioMedicine. ISSN 2352-3964. 80. doi: 10.1016/j.ebiom.2022.104013. Fulltekst i vitenarkiv
• Vergaro, Giuseppe; Gentile, Francesco; Aimo, Alberto; Januzzi, James L.; Richards, A. Mark & Lam, Carolyn S.P. [Vis alle 39 forfattere av denne artikkelen] (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure. ISSN 2055-5822. 9(4), s. 2084–2095. doi: 10.1002/ehf2.13883. Fulltekst i vitenarkiv
• Søraas, Arne Vasli; Grødeland, Gunnveig; Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas & Fevang, Børre [Vis alle 32 forfattere av denne artikkelen] (2022). Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity. Frontiers in Immunology. ISSN 1664-3224. 13, s. 1–12. doi: 10.3389/fimmu.2022.964525. Fulltekst i vitenarkiv Vis sammendrag

  Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals. Methods: We measured inflammatory mediators, antibodies to the SARS-CoV-2 spike and nucleocapsid proteins, and spike peptide-induced release of interferon gamma in whole blood in 51 double-vaccinated individuals infected with Omicron, in 14 infected with Delta, and in 18 healthy controls. The median time points for the first and second samples were 7 and 14 days after symptom onset, respectively. Findings: Infection with Omicron or Delta led to a rapid and similar increase in antibodies to the receptor-binding domain (RBD) of Omicron protein and spike peptide-induced interferon gamma in whole blood. Both the Omicron- and the Delta-infected patients had a mild and transient increase in inflammatory parameters. Interpretation: The results suggest that two vaccine doses are sufficient to mount a rapid and potent immune response upon infection in healthy individuals of with the Omicron variant.

• Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed & Osete, Jordi Requena [Vis alle 31 forfattere av denne artikkelen] (2022). Systemic cell adhesion molecules in severe mental illness: Potential role of intercellular CAM-1 in linking peripheral and neuroinflammation. Biological Psychiatry. ISSN 0006-3223. s. 1–10. doi: 10.1016/j.biopsych.2022.06.029. Fulltekst i vitenarkiv
• Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Moe, Natasha; Aaløkken, Trond Mogens; Macpherson, Magnhild Eide & Nordøy, Ingvild [Vis alle 12 forfattere av denne artikkelen] (2022). Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency. Journal of Clinical Immunology. ISSN 0271-9142. s. 1–11. doi: 10.1007/s10875-022-01318-1. Fulltekst i vitenarkiv
• Englund, Kristine Victoria Brautaset; Østby, Carol Margaret; Broch, Kaspar; Ueland, Thor; Aukrust, Pål & Gude, Einar [Vis alle 8 forfattere av denne artikkelen] (2022). Iron homeostasis in heart transplant recipients randomized to ferric derisomaltose or placebo. Clinical Transplantation. ISSN 0902-0063. 36(7). doi: 10.1111/ctr.14695. Fulltekst i vitenarkiv
• Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet & Lerum, Tøri Vigeland [Vis alle 28 forfattere av denne artikkelen] (2022). High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiac313. Fulltekst i vitenarkiv
• Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen & Yang, Kuan [Vis alle 28 forfattere av denne artikkelen] (2022). Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. Journal of Internal Medicine. ISSN 0954-6820. s. 1–13. doi: 10.1111/joim.13549. Fulltekst i vitenarkiv
• Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Lindberg, Morten; Halvorsen, Bente & Aukrust, Pål [Vis alle 8 forfattere av denne artikkelen] (2022). Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.875152. Fulltekst i vitenarkiv
• Andersen, Thomas; Ueland, Thor; Aukrust, Pål; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir & Staines, Harry [Vis alle 7 forfattere av denne artikkelen] (2022). Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 9, s. 1–9. doi: 10.3389/fcvm.2022.867944. Fulltekst i vitenarkiv Vis sammendrag

  Background: Markers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied in a chest pain population. We wanted to study the association between Podocan levels on admission and the risk of adverse outcomes in a chest pain population with suspected acute coronary syndromes. Methods: A total of 815 patients from the Risk markers in Acute Coronary Syndrome (RACS) trial with suspected coronary chest pain were followed for 7 years. Blood samples were taken immediately after inclusion and stored in the biobank. Associations between Podocan and endpoints were assessed with Cox proportional hazards analyses. Results: The median admission level of Podocan was 0.674 ng/ml (0.566–0.908 ng/ml). No significant association was found between Podocan quartile levels and all-cause death, neither at 1 year nor 2- or 7-years follow-up (p > 0.05 for all). Furthermore, no significant association could be shown between Podocan and cardiac death, myocardial infarction (MI), stroke, or the composites of all-cause death/MI/stroke or cardiac death/MI/stroke (p > 0.05 for all). Similarly, in a subgroup of patients with Troponin T-positive (n = 432) there was no significant association between Podocan and any of the outcome measures (p > 0.05 for all endpoints and points in time). Conclusion: Podocan, a novel ECM biomarker, is not associated with all-cause mortality or other major cardiovascular adverse events in patients admitted with acute chest pain suspected to be of coronary origin.

• Søvik, Signe; Barrat-Due, Andreas; Kåsine, Trine; Olasveengen, Theresa M.; Strand, Marianne Wigernes & Tveita, Anders Aune [Vis alle 16 forfattere av denne artikkelen] (2022). Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation. Journal of Infection. ISSN 0163-4453. 85(1), s. 57–63. doi: 10.1016/j.jinf.2022.05.015. Fulltekst i vitenarkiv
• Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland & Michelsen, Annika Elisabet [Vis alle 16 forfattere av denne artikkelen] (2022). Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology. Platelets. ISSN 0953-7104. 33(4), s. 640–644. doi: 10.1080/09537104.2022.2042238. Fulltekst i vitenarkiv
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Vis alle 15 forfattere av denne artikkelen] (2022). Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis. Translational Psychiatry. ISSN 2158-3188. 12(1). doi: 10.1038/s41398-022-01811-6. Fulltekst i vitenarkiv
• Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude & Skadberg, Øyvind [Vis alle 11 forfattere av denne artikkelen] (2022). Hepcidin predicts 5-year mortality after community-acquired pneumonia. Infectious Diseases. ISSN 2374-4235. 54(6), s. 403–409. doi: 10.1080/23744235.2021.2022194. Fulltekst i vitenarkiv
• Simeone, Paola; Tripaldi, Romina; Michelsen, Annika Elisabet; Ueland, Thor; Liani, Rossella & Ciotti, Sonia [Vis alle 14 forfattere av denne artikkelen] (2022). Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss. Cardiovascular Diabetology. ISSN 1475-2840. 21(1), s. 1–12. doi: 10.1186/s12933-022-01469-w. Fulltekst i vitenarkiv
• Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Vis alle 15 forfattere av denne artikkelen] (2022). Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 116. doi: 10.1016/j.pnpbp.2022.110511. Fulltekst i vitenarkiv
• Simonsen, Hans Erling; Berkman, Raimonda; Skorpen, Per Kristian; Hallstensen, Randi F Ykse & Aukrust, Pål (2022). En mann i 50-årene med tilbakevendende urtikaria, feber og leddsmerter. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(4), s. 1–7. doi: 10.4045/tidsskr.21.0028. Fulltekst i vitenarkiv
• Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid Kufaas & Hansen, John Bjarne [Vis alle 7 forfattere av denne artikkelen] (2022). Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. s. 1–9. doi: 10.1111/jth.15701. Fulltekst i vitenarkiv
• Tennøe, Anders; Murbræch, Klaus; Didriksen, Henriette; Ueland, Thor; Palchevskiy, Vyacheslav & Weigt, Stephen S. [Vis alle 14 forfattere av denne artikkelen] (2022). Serum markers of cardiac complications in a systemic sclerosis cohort. Scientific Reports. ISSN 2045-2322. 12(4661 ). doi: 10.1038/s41598-022-08815-8. Fulltekst i vitenarkiv
• Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T & Kroustallaki, Pinelopi [Vis alle 15 forfattere av denne artikkelen] (2022). NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length. Biochemistry and Biophysics Reports. ISSN 2405-5808. 29. doi: 10.1016/j.bbrep.2022.101211. Fulltekst i vitenarkiv
• Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Søren Erik & Mollnes, Tom Eirik [Vis alle 10 forfattere av denne artikkelen] (2022). Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality. American Journal of Transplantation. ISSN 1600-6135. 22, s. 2016–2027. doi: 10.1111/ajt.17047. Fulltekst i vitenarkiv Vis sammendrag

  In the general population low-grade inflammation has been established as a risk factor for all-cause mortality. We hypothesized that an inflammatory milieu beyond the time of recovery from the surgical trauma could be associated with increased long-term mortality in kidney transplant recipients (KTRs). This cohort study included 1044 KTRs. Median follow-up time post-engraftment was 10.3 years. Inflammation was assessed 10 weeks after transplantation by different composite inflammation scores based on 21 biomarkers. We constructed an overall inflammation score and five pathway-specific inflammation scores (fibrogenesis, vascular inflammation, metabolic inflammation, growth/angiogenesis, leukocyte activation). Mortality was assessed with Cox regression models adjusted for traditional risk factors. A total of 312 (29.9%) patients died during the follow-up period. Hazard ratio (HR) for death was 4.71 (95% CI:2.85-7.81, p

• Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian & Barratt-Due, Andreas [Vis alle 37 forfattere av denne artikkelen] (2022). Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations. Journal of Internal Medicine. ISSN 0954-6820. 291(6), s. 801–812. doi: 10.1111/joim.13458. Vis sammendrag

  Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal (GI) tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long-term respiratory dysfunction remains unknown. Methods: Plasma was collected during hospital admission and after three months from the NOR-Solidarity trial (n = 181) and analysed for markers of gut barrier dysfunction and inflammation. At the three-month follow-up, pulmonary function was assessed by measuring the diffusing capacity of the lungs for carbon monoxide (DLCO ). Rectal swabs for gut microbiota analyses were collected (n = 97) and analysed by sequencing the 16S rRNA gene. Results: Gut microbiota diversity was reduced in COVID-19 patients with respiratory dysfunction, defined as DLCO below the lower limit of normal three months after hospitalisation. These patients also had an altered global gut microbiota composition, with reduced relative abundance of 20 bacterial taxa and increased abundance of five taxa, including Veillonella, potentially linked to fibrosis. During hospitalisation, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 -(P/F ratio)

• Vergaro, Giuseppe; Gentile, Francesco; Meems, Laura M.G.; Aimo, Alberto; Januzzi, James L. & Richards, A. Mark [Vis alle 39 forfattere av denne artikkelen] (2021). NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories. JACC. Heart failure. ISSN 2213-1779. 9(9), s. 653–663. doi: 10.1016/j.jchf.2021.05.014.
• Holt, Margrethe Flesvig; Michelsen, Annika Elisabet; Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina & Massey, Richard J [Vis alle 15 forfattere av denne artikkelen] (2021). The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.800978. Fulltekst i vitenarkiv
• Kåsine, Trine; Riise, Anne Margarita Dyrhol; Barratt-Due, Andreas; Kildal, Anders Benjamin; Olsen, Inge Christoffer & Nezvalova-Henriksen, Katerina [Vis alle 39 forfattere av denne artikkelen] (2021). Neutrophil count predicts outcome in hospitalized COVID-19 patients. Results from the NOR-Solidarity trial. Journal of Internal Medicine. ISSN 0954-6820. 291(2), s. 241–243. doi: 10.1111/joim.13377. Vis sammendrag

  Despite numerous studies on SARS-CoV-2-induced inflammation, we still lack markers for rapid disease progression with admission to intensive care unit (ICU) or respiratory failure(RF). Few studies have evaluated the prognostic value of routine diagnostic repertoire available at most hospitals. The NOR-Solidarity trial is an independent add-on study to the WHO Solidarity trial, evaluating hydroxychloroquine (HCQ)and remdesivir compared to standard of care in hospitalized COVID-19 patients [1]. We explored whether standard biomarkers in peripheral blood could give information on ICU admission and RFin hospitalized COVID-19 patients.

• Tangen, Jorun; Aukrust, Pål; Barratt-Due, Andreas; Skulstad, Helge & Edvardsen, Thor (2021). Reduced cardiac function by echocardiography in a minority of COVID-19 patients three months after hospitalization. Journal of the American Society of Echocardiography. ISSN 0894-7317. doi: 10.1016/j.echo.2021.10.014. Fulltekst i vitenarkiv
• Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter & Yang, Kuan [Vis alle 17 forfattere av denne artikkelen] (2021). NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-98820-0. Fulltekst i vitenarkiv
• Kong, Xiang Yi; Huse, Camilla; Yang, Kuan; Øgaard, Jonas; Jimenez, Natalia Berges & Vik, Erik Sebastian [Vis alle 24 forfattere av denne artikkelen] (2021). Endonuclease v regulates atherosclerosis through c-c motif chemokine ligand 2-mediated monocyte infiltration. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 10(14). doi: 10.1161/JAHA.120.020656. Fulltekst i vitenarkiv
• Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan & Jo, Eunji [Vis alle 28 forfattere av denne artikkelen] (2021). Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses. ISSN 1999-4915. 13:2489(12), s. 1–18. doi: 10.3390/v13122489. Fulltekst i vitenarkiv Vis sammendrag

  Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro. Results: While IFNs alone were insufficient to completely abolish replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IFNα, in combination with remdesivir, EIDD-2801, camostat, cycloheximide, or convalescent serum, proved to be more effective. Transcriptome and metabolomic analyses revealed that the IFNα–remdesivir combination suppressed SARS-CoV-2-mediated changes in Calu-3 cells and lung organoids, although it altered the homeostasis of uninfected cells and organoids. We also demonstrated that IFNα combinations with sofosbuvir, telaprevir, NITD008, ribavirin, pimodivir, or lamivudine were effective against HCV, HEV, FLuAV, or HIV at lower concentrations, compared to monotherapies. Conclusions: Altogether, our results indicated that IFNα can be combined with drugs that affect viral RNA transcription, protein synthesis, and processing to make synergistic combinations that can be attractive targets for further pre-clinical and clinical development against emerging and re-emerging viral infections.

• Jørgensen, Silje Fjellgård; Buechner, Jochen; Myhre, Anders Eivind; Galteland, Eivind; Spetalen, Signe & Kulseth, Mari Ann [Vis alle 19 forfattere av denne artikkelen] (2021). A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT. Journal of Clinical Immunology. ISSN 0271-9142. doi: 10.1007/s10875-021-01189-y. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: GATA2 deficiency is a rare primary immunodeficiency that has become increasingly recognized due to improved molecular diagnostics and clinical awareness. The only cure for GATA2 deficiency is allogeneic hematopoietic stem cell transplantation (allo-HSCT). The inconsistency of genotype-phenotype correlations makes the decision regarding "who and when" to transplant challenging. Despite considerable morbidity and mortality, the reported proportion of patients with GATA2 deficiency that has undergone allo-HSCT is low (~ 35%). The purpose of this study was to explore if detailed clinical, genetic, and bone marrow characteristics could predict end-point outcome, i.e., death and allo-HSCT. Methods: All medical genetics departments in Norway were contacted to identify GATA2 deficient individuals. Clinical information, genetic variants, treatment, and outcome were subsequently retrieved from the patients' medical records. Results: Between 2013 and 2020, we identified 10 index cases or probands, four additional symptomatic patients, and no asymptomatic patients with germline GATA2 variants. These patients had a diverse clinical phenotype dominated by cytopenia (13/14), myeloid neoplasia (10/14), warts (8/14), and hearing loss (7/14). No valid genotype-phenotype correlations were found in our data set, and the phenotypes varied also within families. We found that 11/14 patients (79%), with known GATA2 deficiency, had already undergone allo-HSCT. In addition, one patient is awaiting allo-HSCT. The indications to perform allo-HSCT were myeloid neoplasia, disseminated viral infection, severe obliterating bronchiolitis, and/or HPV-associated in situ carcinoma. Two patients died, 8 months and 7 years after allo-HSCT, respectively. Conclusion: Our main conclusion is that the majority of patients with symptomatic GATA2 deficiency will need allo-HSCT, and a close surveillance of these patients is important to find the "optimal window" for allo-HSCT. We advocate a more offensive approach to allo-HSCT than previously described.

• Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid & Andreou, Dimitrios [Vis alle 31 forfattere av denne artikkelen] (2021). Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain, Behavior, and Immunity. ISSN 0889-1591. 99, s. 299–306. doi: 10.1016/j.bbi.2021.10.017. Fulltekst i vitenarkiv Vis sammendrag

  Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic lipid ratios have been shown to correlate with circulating levels of inflammatory biomarkers in SMI. It is, however, not yet known if increased systemic cholesterol load leads to inflammasome activation in these patients. Methods We tested the hypothesis that patients with SCZ and BD display higher circulating levels compared to healthy individuals of key members of the IL-18 system using a large patient cohort (n = 1632; including 737 SCZ and 895 BD), and healthy controls (CTRL; n = 1070). In addition, we assessed associations with coronary artery disease risk factors in SMI, focusing on relevant inflammasome-related, neuroendocrine, and lipid markers. Results We report higher baseline levels of circulating IL-18 system components (IL-18, IL-18BPA, IL-18R1), and increased expression of inflammasome-related genes (NLRP3 and NLRC4) in the blood of patients relative to CTRL. We demonstrate a cholesterol dyslipidemia pattern in psychotic disorders, and report correlations between levels of blood cholesterol types and the expression of inflammasome system elements in SMI. Conclusions Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.

• Edvardsen, Magnus; Hansen, Ellen-Sofie; Hindberg, Kristian; Morelli, Vania Maris; Ueland, Thor & Aukrust, Pål [Vis alle 9 forfattere av denne artikkelen] (2021). Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism. Blood. ISSN 0006-4971. 138(22), s. 2269–2277. doi: 10.1182/blood.2021011494. Fulltekst i vitenarkiv
• Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina & Kåsine, Trine [Vis alle 27 forfattere av denne artikkelen] (2021). Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. ISSN 2045-2322. 11, s. 1–12. doi: 10.1038/s41598-021-02547-x. Fulltekst i vitenarkiv
• Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda & Aukrust, Pål [Vis alle 11 forfattere av denne artikkelen] (2021). Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism. Thrombosis Research. ISSN 0049-3848. 208, s. 121–126. doi: 10.1016/j.thromres.2021.10.020. Fulltekst i vitenarkiv
• Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian & Broch, Kaspar [Vis alle 11 forfattere av denne artikkelen] (2021). Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction. Open heart. ISSN 2053-3624. 8(1). doi: 10.1136/openhrt-2020-001492. Fulltekst i vitenarkiv
• Broch, Kaspar; Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria & Bendz, Bjørn [Vis alle 23 forfattere av denne artikkelen] (2021). Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology. ISSN 0735-1097. 77(15), s. 1845–1855. doi: 10.1016/j.jacc.2021.02.049. Fulltekst i vitenarkiv
• Olsen, Maria Belland; Gregersen, Ida; Sandanger, Øystein; Yang, Kuan; Sokolova, Marina & Halvorsen, Bente E. [Vis alle 10 forfattere av denne artikkelen] (2021). Targeting the Inflammasome in Cardiovascular Disease. JACC: Basic to Translational Science. ISSN 2452-302X. 7(1), s. 84–98. doi: 10.1016/j.jacbts.2021.08.006. Fulltekst i vitenarkiv
• Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter & Schultz, Nina Haagenrud [Vis alle 21 forfattere av denne artikkelen] (2021). Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia. European Heart Journal. ISSN 0195-668X. 42(39), s. 4064–4072. doi: 10.1093/eurheartj/ehab506. Fulltekst i vitenarkiv
• Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Vis alle 30 forfattere av denne artikkelen] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, s. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023. Fulltekst i vitenarkiv
• Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar; Wedervang-Resell, Kirsten & Nerland, Stener [Vis alle 25 forfattere av denne artikkelen] (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. ISSN 0033-2917. s. 1–10. doi: 10.1017/S0033291721003056. Fulltekst i vitenarkiv
• Ueland, Thor; Gullestad, Lars; Kou, Lei; Young, James B.; Pfeffer, Marc A. & van Veldhuisen, Dirk J. [Vis alle 11 forfattere av denne artikkelen] (2021). Growth differentiation factor 15 predicts poor prognosis in patients with heart failure and reduced ejection fraction and anemia: results from RED-HF. Clinical Research in Cardiology. ISSN 1861-0684. s. 1–11. doi: 10.1007/s00392-021-01944-6. Fulltekst i vitenarkiv
• Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam & Gregersen, Ida [Vis alle 10 forfattere av denne artikkelen] (2021). IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria. BMC Infectious Diseases. ISSN 1471-2334. 21. doi: 10.1186/s12879-021-06751-y. Fulltekst i vitenarkiv
• Skarpengland, Tonje; Macpherson, Magnhild Eide; Hov, Johannes R.; Kong, Xiang Yi; Bohov, Pavol & Halvorsen, Bente [Vis alle 10 forfattere av denne artikkelen] (2021). Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency. Journal of Clinical Immunology. ISSN 0271-9142. s. 1–12. doi: 10.1007/s10875-021-01146-9.
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Leon de la Fuente, Ricardo & Grundt, Magnea Heidi Jonsdottir [Vis alle 9 forfattere av denne artikkelen] (2021). Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome. BMC Cardiovascular Disorders. ISSN 1471-2261. 21(1), s. 1–12. doi: 10.1186/s12872-021-02306-w.
• Lekva, Tove; Roland, Marie Cecilie; Estensen, M.E.; Norwitz, Errol R.; Tilburgs, Tamara & Henriksen, Tore [Vis alle 12 forfattere av denne artikkelen] (2021). Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-99140-z. Fulltekst i vitenarkiv
• Engh, John; Ueland, Thor; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål & Boye, Birgitte [Vis alle 27 forfattere av denne artikkelen] (2021). Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study. Schizophrenia Bulletin. ISSN 0586-7614. s. 1–10. doi: 10.1093/schbul/sbab106.
• Hustad, Nina Berger; Degerud, Hanna M; Hjelmerud, Ingrid; Fraz, Mai Sasaki Aanensen; Nordøy, Ingvild & Trøseid, Marius [Vis alle 9 forfattere av denne artikkelen] (2021). Real-World Experiences With Facilitated Subcutaneous Immunoglobulin Substitution in Patients With Hypogammaglobulinemia, Using a Three-Step Ramp-Up Schedule. Frontiers in Immunology. ISSN 1664-3224. 12, s. 1–7. doi: 10.3389/fimmu.2021.670547. Fulltekst i vitenarkiv
• Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Vis alle 13 forfattere av denne artikkelen] (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, s. 1–23. doi: 10.7554/ELIFE.59828. Fulltekst i vitenarkiv
• Ueland, Thor; Abraityte, Judita Aurelija; Norum, Hilde Margrethe; Sharanga, Varathalingam; Gullestad, Lars & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulating regulators of the wingless pathway in precapillary pulmonary hypertension. Respirology (Carlton South. Print). ISSN 1323-7799. 26(6), s. 574–581. doi: 10.1111/resp.14048. Fulltekst i vitenarkiv
• Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K. & Hansen, John-Bjarne [Vis alle 7 forfattere av denne artikkelen] (2021). Plasma levels of leptin and risk of future incident venous thromboembolism. Thrombosis and Haemostasis. ISSN 0340-6245. doi: 10.1055/s-0041-1732295. Fulltekst i vitenarkiv
• Awoyemi, Ayodeji Olawale; Mayerhofer, Christiane Caroline; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D. & Lappegård, Knut Tore [Vis alle 23 forfattere av denne artikkelen] (2021). Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine. ISSN 2352-3964. 70. doi: 10.1016/j.ebiom.2021.103511. Fulltekst i vitenarkiv
• Barratt-Due, Andreas; Olsen, Inge Christoffer; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Lund-Johansen, Fridtjof & Hoel, Hedda Benedicte [Vis alle 43 forfattere av denne artikkelen] (2021). Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Annals of Internal Medicine. ISSN 0003-4819. 174(9), s. 1261–1269. doi: 10.7326/M21-0653. Vis sammendrag

  Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known. Objective: To evaluate the effects of remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx. Design: NOR-Solidarity is an independent, add-on, randomized controlled trial to the WHO Solidarity trial that included biobanking and 3 months of clinical follow-up (ClinicalTrials.gov: NCT04321616). Setting: 23 hospitals in Norway. Patients: Eligible patients were adults hospitalized with confirmed SARS-CoV-2 infection. Intervention: Between 28 March and 4 October 2020, a total of 185 patients were randomly assigned and 181 were included in the full analysis set. Patients received remdesivir (n = 42), HCQ (n = 52), or standard of care (SoC) (n = 87). Measurements: In addition to the primary end point of WHO Solidarity, study-specific outcomes were viral clearance in oropharyngeal specimens, the degree of respiratory failure, and inflammatory variables. Results: No significant differences were seen between treatment groups in mortality during hospitalization. There was a marked decrease in SARS-CoV-2 load in the oropharynx during the first week overall, with similar decreases and 10-day viral loads among the remdesivir, HCQ, and SoC groups. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammatory variables in plasma or serum. The lack of antiviral effect was not associated with symptom duration, level of viral load, degree of inflammation, or presence of antibodies against SARS-CoV-2 at hospital admittance. Limitation: The trial had no placebo group. Conclusion: Neither remdesivir nor HCQ affected viral clearance in hospitalized patients with COVID-19.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; de la Fuente, Ricardo Leon & Pønitz, Volker [Vis alle 10 forfattere av denne artikkelen] (2021). Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome. Journal of Internal Medicine. ISSN 0954-6820. s. 1–16. doi: 10.1111/joim.13339.
• Roland, Marie Cecilie; Godang, Kristin; Aukrust, Pål; Henriksen, Tore & Lekva, Tove (2021). Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants. Scientific Reports. ISSN 2045-2322. 11(1), s. 1–13. doi: 10.1038/s41598-021-85777-3. Fulltekst i vitenarkiv
• Ueland, Thor; Astrup, Elisabeth; Otterdal, Kari; Lekva, Tove; Janardhanan, Jeshina & Prakash, John A. [Vis alle 11 forfattere av denne artikkelen] (2021). Secreted wnt antagonists in scrub typhus. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 15(4), s. 1–12. doi: 10.1371/journal.pntd.0009185. Fulltekst i vitenarkiv
• Ueland, Thor; Dyrhol-Riise, Anne Ma; Woll, Bjørn Martin; Holten, Aleksander Rygh; Pettersen, Frank O. & Lind, Andreas [Vis alle 10 forfattere av denne artikkelen] (2021). Increased inflammatory markers reflecting fibrogenesis are independently associated with cardiac involvement in hospitalized COVID-19 patients. Journal of Infection. ISSN 0163-4453. 82(5), s. 186–230. doi: 10.1016/j.jinf.2021.01.017.
• Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma & Tonby, Kristian [Vis alle 15 forfattere av denne artikkelen] (2021). Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. Journal of Neurology. ISSN 0340-5354. doi: 10.1007/s00415-021-10517-6. Fulltekst i vitenarkiv
• Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato & Lauritzen, Trine [Vis alle 12 forfattere av denne artikkelen] (2021). Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia. Open Forum Infectious Diseases. ISSN 2328-8957. 8(4). doi: 10.1093/ofid/ofab082. Fulltekst i vitenarkiv
• Thorsen, Inga Strand; Gøransson, Lasse Gunnar; Ueland, Thor; Aukrust, Pål; Manhenke, Cord A & Skadberg, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2021). The relationship between Fibroblast Growth Factor 23 (FGF23) and cardiac MRI findings following primary PCI in patients with acute first time STEMI. International journal of cardiology: Heart and Vasculature (IJCHA). ISSN 2352-9067. 33:100727, s. 1–6. doi: 10.1016/j.ijcha.2021.100727. Fulltekst i vitenarkiv
• Bjørkto, Magnus Holter; Barratt-Due, Andreas; Nordøy, Ingvild; Dörje, Christina; Galteland, Eivind & Lind, Andreas [Vis alle 9 forfattere av denne artikkelen] (2021). The use of eculizumab in Capnocytophaga canimorsus associated thrombotic microangiopathy: a case report. BMC Infectious Diseases. ISSN 1471-2334. 21:137, s. 1–6. doi: 10.1186/s12879-021-05789-2.
• Edvardsen, Magnus; Hindberg, Kristian; Hansen, Ellen-Sofie; Morelli, Vania Maris; Ueland, Thor & Aukrust, Pål [Vis alle 9 forfattere av denne artikkelen] (2021). Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism. Blood Advances. ISSN 2473-9529. 5(1), s. 224–232. doi: 10.1182/bloodadvances.2020003135. Fulltekst i vitenarkiv
• Fraz, Mai Sasaki Aanensen; Moe, Natasha; Rootwelt-Revheim, Mona-Elisabeth; Stavrinou, Maria; Durheim, Michael & Nordøy, Ingvild [Vis alle 11 forfattere av denne artikkelen] (2021). Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency—Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.617985. Fulltekst i vitenarkiv
• Pan, Hongchao; Peto, Richard; Henao-Restrepo, Ana Maria; Preziosi, Marie-Pierre; Sathiyamoorthy, Vasee & Karim, Quarraisha Abdool [Vis alle 74 forfattere av denne artikkelen] (2020). Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results. New England Journal of Medicine. ISSN 0028-4793. 384(6), s. 497–511. doi: 10.1056/NEJMoa2023184.
• Mayerhofer, Christiane Caroline; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale & Vestad, Beate [Vis alle 17 forfattere av denne artikkelen] (2020). Low fibre intake is associated with gut microbiota alterations in chronic heart failure. ESC Heart Failure. ISSN 2055-5822. 7(2), s. 456–466. doi: 10.1002/ehf2.12596. Fulltekst i vitenarkiv
• Tholin, Birgitte; Hauge, Marit Teigen; Aukrust, Pål; Fehrle, Lutz & Tvedt, Tor Henrik Anderson (2020). Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report. Journal of Medical Case Reports. ISSN 1752-1947. 14:187, s. 1–5. doi: 10.1186/s13256-020-02503-9. Fulltekst i vitenarkiv
• George, Marc J; Kleveland, Ola; Garcia-Hernandez, Jorge; Palmen, Jutta; Lovering, Ruth & Wiseth, Rune [Vis alle 13 forfattere av denne artikkelen] (2020). Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 16(12), s. 1–21. doi: 10.1161/JAHA.119.015628. Fulltekst i vitenarkiv Vis sammendrag

  Background Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non-ST-segment-elevation myocardial infarction trial, the first randomized trial of interleukin 6 blockade in myocardial infarction, concentration of both C-reactive protein and troponin T were reduced in the active treatment arm. In this follow-up study, an aptamer-based proteomic approach was employed to discover additional plasma proteins modulated by tocilizumab treatment to gain novel insights into the effects of this therapeutic approach. Methods and Results Plasma from percutaneous coronary intervention-treated patients, 24 in the active intervention and 24 in the placebo-control arm, drawn 48 hours postrandomization were randomly selected for analysis with the SOMAscan assay. Employing slow off-rate aptamers, the relative abundance of 1074 circulating proteins was measured. Proteins identified as being significantly different between groups were subsequently measured by enzyme immunoassay in the whole trial cohort (117 patients) at all time points (days 1-3 [7 time points] and 3 and 6 months). Five proteins identified by the SOMAscan assay, and subsequently confirmed by enzyme immunoassay, were significantly altered by tocilizumab administration. The acute-phase proteins lipopolysaccharide-binding protein, hepcidin, and insulin-like growth factor-binding protein 4 were all reduced during the hospitalization phase, as was the monocyte chemoattractant C-C motif chemokine ligand 23. Proteinase 3, released primarily from neutrophils, was significantly elevated. Conclusions Employing the SOMAscan aptamer-based proteomics platform, 5 proteins were newly identified that are modulated by interleukin 6 antagonism and may mediate the therapeutic effects of tocilizumab in non-ST-segment-elevation myocardial infarction.

• Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud & Alfsnes, Katrine [Vis alle 25 forfattere av denne artikkelen] (2020). Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction. JACC: Basic to Translational Science. ISSN 2452-302X. 5(12), s. 1210–1224. doi: 10.1016/j.jacbts.2020.09.013. Fulltekst i vitenarkiv
• Sikkeland, Liv Ingunn Bjoner; Qiao, Shuo Wang; Ueland, Thor; Myrdal, Ole Henrik; Wyrozemski, Lukasz Adam & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2020). Lung CD4+ T cells in patients with lung fibrosis produce pro-fibrotic IL-13 together with IFNγ. European Respiratory Journal. ISSN 0903-1936. 57:2000983(3), s. 1–4. doi: 10.1183/13993003.00983-2020. Fulltekst i vitenarkiv
• Hovland, Anders; Narverud, Ingunn; Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Aagnes, Inger & Ueland, Thor [Vis alle 17 forfattere av denne artikkelen] (2020). Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers. Journal of Clinical Lipidology. ISSN 1933-2874. s. 1–8. doi: 10.1016/j.jacl.2020.12.006. Fulltekst i vitenarkiv
• Ueland, Thor; Estensen, Mette-Elise; Grindheim, Guro; Bollerslev, Jens; Henriksen, Tore & Aukrust, Pål [Vis alle 9 forfattere av denne artikkelen] (2020). Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies. Journal of Hypertension. ISSN 0263-6352. 38(7), s. 1347–1354. doi: 10.1097/HJH.0000000000002362. Fulltekst i vitenarkiv
• Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca & Hammarström, Clara Louise [Vis alle 15 forfattere av denne artikkelen] (2020). Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLOS ONE. ISSN 1932-6203. 15:e0243759(12), s. 1–14. doi: 10.1371/journal.pone.0243759. Fulltekst i vitenarkiv
• Nordøy, Ingvild; Fraz, Mai Sasaki Aanensen; Trøseid, Marius; Fevang, Børre & Aukrust, Pål (2020). Høyt serum-ferritin ikke kun uttrykk for leversvikt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(8). doi: 10.4045/tidsskr.20.0376.
• Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian & Pischke, Soeren [Vis alle 22 forfattere av denne artikkelen] (2020). Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports. ISSN 2045-2322. 10. doi: 10.1038/s41598-020-78710-7. Fulltekst i vitenarkiv
• Sokolova, Marina; Yang, Kuan; Hansen, Simen Hyll; Louwe, Maria Cornelia; Kummen, Martin & Hov, Johannes Espolin Roksund [Vis alle 12 forfattere av denne artikkelen] (2020). NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet. Scientific Reports. ISSN 2045-2322. 10:21006, s. 1–16. doi: 10.1038/s41598-020-76497-1. Fulltekst i vitenarkiv
• Aamodt, Anne Hege; Harbo, Hanne Flinstad; Eldøen, Guttorm; Barratt-Due, Andreas & Aukrust, Pål (2020). Hvordan påvirkes hjernen ved covid-19? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(10), s. 968–969. doi: 10.4045/tidsskr.20.0444.
• Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika & Lekva, Tove [Vis alle 19 forfattere av denne artikkelen] (2020). YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circulation: Heart Failure. ISSN 1941-3289. 13(10). doi: 10.1161/CIRCHEARTFAILURE.119.006643. Fulltekst i vitenarkiv
• Lekva, Tove; Gullestad, Lars; Broch, Kaspar; Aukrust, Pål; Andreassen, Arne K. & Ueland, Thor (2020). Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension. Scientific Reports. ISSN 2045-2322. 10(1), s. 1–8. doi: 10.1038/s41598-020-75654-w. Fulltekst i vitenarkiv
• Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian & Michelsen, Annika [Vis alle 26 forfattere av denne artikkelen] (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 147(1), s. 92–98. doi: 10.1016/j.jaci.2020.09.007. Fulltekst i vitenarkiv
• Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne & Holten, Aleksander Rygh [Vis alle 32 forfattere av denne artikkelen] (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients . Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(40), s. 25018–25025. doi: 10.1073/pnas.2010540117. Fulltekst i vitenarkiv
• Hansen, Ellen-Sofie; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor & Hansen, John-Bjarne [Vis alle 8 forfattere av denne artikkelen] (2020). Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism. Blood. ISSN 0006-4971. 136(16), s. 1863–1870. doi: 10.1182/blood.2019004572. Fulltekst i vitenarkiv
• Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter & Vågbø, Cathrine [Vis alle 17 forfattere av denne artikkelen] (2020). Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Research (NAR). ISSN 0305-1048. 48(8), s. 4463–4479. doi: 10.1093/nar/gkaa115. Fulltekst i vitenarkiv
• Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin & Otterdal, Kari [Vis alle 14 forfattere av denne artikkelen] (2020). Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.574500. Fulltekst i vitenarkiv
• Quiles Jimenez, Ana Maria Teresa; Gregersen, Ida; Sousa, Mirta; Abbas, Azhar; Kong, Xiang Yi & Alseth, Ingrun [Vis alle 13 forfattere av denne artikkelen] (2020). N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 533(4), s. 631–637. doi: 10.1016/j.bbrc.2020.09.057. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Lindberg, Morten; Halvorsen, Bente & Aukrust, Pål [Vis alle 8 forfattere av denne artikkelen] (2022). Corrigendum: Circulating T cell activation and exhaustion markers are associated with radiation pneumonitis and poor survival in non-small-cell lung cancer, (Front. Immunol, (2022), 13, (875152), 10.3389/fimmu.2022.875152). Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.1051156.
• Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Barratt-Due, Andreas; Dyrhol-Riise, Anne Ma; Aukrust, Pål & Trøseid, Marius [Vis alle 7 forfattere av denne artikkelen] (2022). Remdesivir modifies interferon response in hospitalized COVID-19 patients. Journal of Infection. ISSN 0163-4453. 85(5), s. 573–607. doi: 10.1016/j.jinf.2022.07.021.
• Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Søraas, Arne Vasli; Fevang, Børre & Steffensen, Anne Katrine [Vis alle 14 forfattere av denne artikkelen] (2022). Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2. Viruses. ISSN 1999-4915. 14(11). doi: 10.3390/v14112420. Vis sammendrag

  The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result of a higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether the Omicron variant generates a higher viral load than that of the Delta variant in saliva and nasopharynx. Both specimens were collected from 52 Omicron and 17 Delta cases at two time points one week apart and analyzed by qRT-PCR. Viral load was measured as 10 log RNA genome copies per 1000 human cells according to the WHO reference standard. We found that Omicron cases carried a higher viral load and had more sustained viral shedding compared to the Delta cases, especially in the nasopharynx.

• Aukrust, Pål; Kleveland, Ola & Gullestad, Lars (2021). Targeting IL-6 Trans-Signaling: Amplifying the Benefits of IL-6 Inhibition in Myocardial Infarction. JACC: Basic to Translational Science. ISSN 2452-302X. 6(5), s. 444–446. doi: 10.1016/j.jacbts.2021.01.007.
• Ishaq, Bushra; Aukrust, Pål; Diaz, Esperanza; Solbakk, Jan Helge; Bjertness, Espen & Tyssvang, Marius [Vis alle 7 forfattere av denne artikkelen] (2021). Hvorfor er koronasmitten så høy blant minoriteter? Vi trenger grundige analyser. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
• Tangen, Jorun; Aukrust, Pål; Barrat-Due, A; Trøseid, Marius; Olsen, Inge Christoffer & Nezvalova-Henriksen, Katerina [Vis alle 15 forfattere av denne artikkelen] (2021). Cardiac function is normal in most patients recovered from COVID-19 .
• Andersen, Thomas; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Ueland, Thor & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulation 2021 (Nov. 8); 144 (Suppl. 1): A12013. Procollagen type-1 N-terminal propeptide, a collagen synthesis biomarker, is associated with adverse clinical outcome in patients with nsuspected acute coronary syndrome. . Vis sammendrag

  Introduction: Procollagen type 1 N-terminal Propeptide (P1NP) is a precursor protein of collagen type 1, a major component of cardiac extracellular matrix. The association of P1NP to clinical outcome in patients with suspected acute coronary syndrome (ACS) has so far not been investigated. The objective of the present study was to assess the predictive value of P1NP concerning adverse clinical outcome in patients admitted for suspected ACS. Methods: Plasma P1NP was measured with an enzyme immune assay in samples taken upon admission from patients enrolled in the Risk markers in Acute Coronary Syndrome (RACS) study (NCT00521976), a Norwegian single center study including patients with suspected ACS from November 2002 to September 2003. The primary endpoint was a composite of all-cause mortality, myocardial infarction (MI), or stroke within 1 year. Additional analyzes included the composite and its individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. Associations between quartiles of P1NP and the endpoints were assessed in both univariate analyzes and in stepwise multivariable Cox regression analyzes fitted with significant clinical variables, past medical history, medication, TnT, BNP, and eGFR before P1NP was introduced. Results: Samples were available from 813 patients (Mean age 69.6 years, 61.4 % males, 52.9% elevated TnT). Mean P1NP levels was 46.2 ng/mL (CI 44.8-47.6). In multivariable Cox analyzes, P1NP was found to be significantly associated with the composite of all-cause mortality, MI, or stroke at 1 year (HR [Q4vsQ1] 1.82, CI 1.12-2.98; p=0.017). This association did not remain significant beyond 1 year. No association was seen for any of the individual components, or cardiac death, at any timepoint, or in patients with elevated TNT (p>0.05 for all). Conclusions: This first study on P1NP in suspected ACS revealed a significant association with adverse clinical outcome (all-cause death, MI, or stroke) at 1 year. However, no predictive value was found concerning outcome for the individual components of the primary endpoint, or cardiac death, at any timepoint, or in patients with elevated TNT.

• Andersen, Thomas; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Ueland, Thor & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulation 2021 (Nov. 8); 144 (Suppl. 1): A9149. The novel Wnt-Pathway inhibitor podogan is not associated with all-cause mortality or cardiovascular outcome in patients admitted with suspected acute coronary syndrome. . Vis sammendrag

  Introduction: Podocan, a novel extracellular matrix glycoprotein, is a smooth muscle cell regulator and abundantly expressed in human atheroma. The association of Podocan with cardiovascular outcome remains unclear. The aim of this study was to assess the predictive value of Podocan concerning adverse outcome in patients admitted with acute chest pain suspected to be acute coronary syndrome (ACS). Methods: Plasma Podocan was measured with an enzyme immune assay in samples taken upon hospital admission from patients with suspected ACS who were enrolled in the Risk markers in Acute Coronary Syndrome (RACS) study (NCT00521976). RACS was a Norwegian single center study including patients from November 2002 to September 2003. The primary outcome was a composite of all-cause mortality, myocardial infarction, or stroke within 7 years. Additional analyzes included these individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. Associations between quartiles of Podocan and the primary outcome, its individual components, and cardiac death were assessed in both univariate analyzes and in stepwise multivariable Cox regression analyzes fitted with significant clinical variables, past medical history, medication, TnT, BNP, and eGFR before Podocan was introduced. Results: Samples were available from 815 patients (mean age: 69.6 years, male: 61.3%, elevated TnT: 53.0%). Mean Podocan level was 1.03 ng/mL (CI 0.93-1.13). Podocan was neither associated with the primary composite endpoint within 7 years in univariate analyzes (X2 analyzes (p=0.426), AUROC 0.518 (p=0.374), Kaplan Meier analyzes (log-rank test p=0.594), and Cox regression (p=0.595)), nor in multivariable Cox regression analyzes (p=0.744). Similar results were found by analyzes of the individual components of the primary outcome and of cardiac death for all time points, as well as in subgroup analyzes of patients with elevated TnT (p>0.05 for all). Conclusions: This first report in the literature on Podocan in acute chest pain did not reveal any significant predictive value of this novel wnt-pathway inhibitor concerning the combination of all-cause death, MI, or stroke, its individual components or cardiac death in patients admitted with suspected ACS, irrespective of TnT status.

• Lekva, Tove; Roland, Marie Cecilie Paasche; Estensen, Mette E.; Norwitz, Errol R.; Tilburgs, Tamara & Henriksen, Tore [Vis alle 12 forfattere av denne artikkelen] (2021). Author Correction: Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence (Scientific Reports, (2021), 11, 1, (19735), 10.1038/s41598-021-99140-z). Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-00917-z.
• Ishaq, Bushra; Aukrust, Pål; Diaz, Esperanza; Solbakk, Jan-Helge; Østby, Lars & Tyssvang, Marius [Vis alle 7 forfattere av denne artikkelen] (2021). Smitte blant innvandrere: Vi forholder oss i aller høyeste grad til eksisterende forskning. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. s. 33–33.
• Ishaq, Bushra; Aukrust, Pål; Diaz, Esperanza; Solbakk, Jan-Helge; Østby, Lars & Bjertness, Espen [Vis alle 8 forfattere av denne artikkelen] (2021). Vi trenger grundige analyser av den høye minoritetssmitten. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. s. 26–27.
• Tveiten, Hallgeir; Lehne, Gustav; Aukrust, Pål; Rivero, Jezabel Rodriguez & Skjønsberg, Ole Henning (2020). En mann i 40-årene med økendepustevansker. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(6), s. 1–7. doi: 10.4045/tidsskr.19.0692.
• Narverud, Ingunn; Christensen, Jacob Juel; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2020). Profiling of immune‐related gene expression in children with familial hypercholesterolaemia.
• Ueland, Thor; Holter, Jan Cato; Holten, Aleksander Rygh; Muller, Karl Erik; Lind, A. & Bekken, Gry Klouman [Vis alle 10 forfattere av denne artikkelen] (2020). Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure: MMP-9 and respiratory failure in COVID-19. Journal of Infection. ISSN 0163-4453. 81(3), s. e41–e43. doi: 10.1016/j.jinf.2020.06.061.
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 10 forfattere av denne artikkelen] (2020). Angiopoietin-like 4 protein is a long-term predictor of outcome in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library. Vis sammendrag

  Introduction: Angiopoietin-like 4 protein (ANGPTL4) has multiple physiological functions including modulation of angiogenesis, vascular permeability and lipid-metabolism. Acting as an inhibitor of lipoprotein lipase, ANGPTL4 has previously been found to be associated with lipid levels and risk of coronary artery disease. Purpose: To assess the prognostic value of ANGPTL4 for long-term outcome, in addition to conventional clinical risk factors, in chest-pain patients admitted with clinically suspected acute coronary syndrome (ACS). Methods: 1853 patients from Norway and Northern-Argentina were consecutively included in this prospective 2-center cohort study. ANGPTL4 concentrations were measured in 1829 admission-samples by enzyme immunoassay. Data were pooled for analysis. Multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-months, comparing event rates across ANGPTL4-quartiles (Q1-4). Of patients with suspected ACS, 845 had a troponin T (TnT) value above the detection-limit. Subgroup analysis was performed for all-cause mortality in patients stratified according to TnT release >/≤ 0.01 ng/mL. Results: During 24-months follow-up, 254 patients (13.9%) died, of which 150 (8.2%) suffered cardiac death and 76 (4.2%) SCD. Patients who died had significantly higher admission-levels of ANGPTL4 compared to long-term survivors [4.99 (3.54 – 8.37) ng/mL versus 3.18 (2.14 – 4.78) ng/mL (median, 25 and 75% percentiles), p < 0.001]. A stepwise increase in risk of all-cause death was seen with increasing quartiles of ANGPTL4, Figure 1. For cardiac death, ANGPTL4-levels in Q4 [Hazard Ratio (HR) 2.86 (95% confidence interval (CI); 1.10 – 7.45), p = 0.031] as compared to Q1 were found to be an independent predictor of outcome. Similar results were seen for SCD in adjusted analysis for ANGPTL4-Q4 [HR 7.37 (95% CI; 1.75 – 31.1), p = 0.007] as compared to Q1. In subgroup analysis, ANGPTL4 concentrations in the highest quartile were significantly associated with increased risk of all-cause mortality in patients with TnT-release [HR 2.07 (95% CI, 1.06 – 4.02), p = 0.032], but not in patients without TnT-release. Conclusion: High admission-levels of ANGPTL4 were found to be an independent long-term predictor of all-cause mortality, cardiac death and SCD in patients with suspected ACS.

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