Pål Aukrust

• Abraityte, Judita Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James; McMurray, John J.V.; van Veldhuisen, Dirk J.; Gullestad, Lars & Ueland, Thor (2019). T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clinical Research in Cardiology.  ISSN 1861-0684.  108(2), s 133- 141 . doi: 10.1007/s00392-018-1331-2
• Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey & Åsvold, Bjørn Olav (2019). Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition. Circulation. Genomic and precision medicine.  ISSN 2574-8300.  12:e002335(1) . doi: 10.1161/CIRCGEN.118.002335
• Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore; Bollerslev, Jens; Espevik, Terje; Aukrust, Pål; Halvorsen, Bente & Holven, Kirsten Bjørklund (2019). Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children. Molecular Nutrition & Food Research.  ISSN 1613-4125.  63(7) . doi: 10.1002/mnfr.201800990
• Holm, Sverre; Oma, Ingvild; Hagve, Tor-Arne; Saatvedt, Kjell; Brosstad, Frank Roger; Mikkelsen, Knut; Rydningen, Hans; Risnes, Ivar; Almdahl, Sven Martin; Ueland, Thor; Aukrust, Pål; Halvorsen, Bente & Hollan, Ivana (2019). Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: A cross-sectional study. BMJ Open.  ISSN 2044-6055.  9(5) . doi: 10.1136/bmjopen-2019-030651
• Husebø, Gunnar; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pål & Eagan, Tomas Mikal (2019). Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study. Respiratory Medicine.  ISSN 0954-6111.  152, s 81- 88 . doi: 10.1016/j.rmed.2019.04.019
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund & Fevang, Børre (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports.  ISSN 2045-2322.  9:167, s 1- 10 . doi: 10.1038/s41598-018-35367-7 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine.  ISSN 0033-2917.  49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142
• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Stig Haugset; Lauritzen, Trine; Oppen, Kjersti; Husebye, Einar; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2019). Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph.  ISSN 2312-508X.  5(1) . doi: 10.1183/23120541.00014-2019 Fulltekst i vitenarkiv.
• Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus. Diabetes/Metabolism Research Reviews.  ISSN 1520-7552.  :e3114, s 1- 9 . doi: 10.1002/dmrr.3114
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål & Wallentin, Lars (2019). Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  39(2), s 294- 302 . doi: 10.1161/ATVBAHA.118.311042
• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Fulltekst i vitenarkiv.
• Abadpour, Shadab; Halvorsen, Bente; Sahraoui, Afaf; Korsgren, Olle; Aukrust, Pål & Scholz, Hanne (2018). Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT. Journal of Molecular Endocrinology.  ISSN 0952-5041.  60(3), s 171- 183 . doi: 10.1530/JME-17-0182
• Arora, Satish; Andreassen, Arne K.; Karason, Kristjan; Gustafsson, Finn; Eiskjær, Hans; Bøtker, Hans Erik; Rådegran, Göran; Gude, Einar; Ioanes, Dan; Solbu, Dag; Dellgren, Göran; Ueland, Thor; Aukrust, Pål & Gullestad, Lars (2018). Effect of everolimus initiation and calcineurin inhibitor elimination on cardiac allograft vasculopathy in de novo heart transplant recipients. Circulation: Heart Failure.  ISSN 1941-3289.  11:e004050(9) . doi: 10.1161/CIRCHEARTFAILURE.117.004050 Fulltekst i vitenarkiv.
• Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Yndestad, Arne; Halvorsen, Bente; Brustugun, Odd Terje; Aukrust, Pål; Ueland, Thor & Helland, Åslaug (2018). Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease. BMC Cancer.  ISSN 1471-2407.  18(1) . doi: 10.1186/s12885-018-4659-0
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139, s 37- 45 . doi: 10.1111/acps.12971
• Ellingsen, Trygve; Lappegård, Jostein; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas & Hansen, John-Bjarne (2018). Plasma hepcidin is associated with future risk of venous thromboembolism. Blood Advances.  ISSN 2473-9529.  2(11), s 1191- 1197 . doi: 10.1182/bloodadvances.2018018465 Fulltekst i vitenarkiv.
• Heldal, Torbjørn Fossum; Ueland, Thor; Jenssen, Trond Geir; Hartmann, Anders; Reisæter, Anna Varberg; Aukrust, Pål; Michelsen, Annika & Åsberg, Anders (2018). Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study. Transplant International.  ISSN 0934-0874.  31(5), s 510- 519 . doi: 10.1111/tri.13116
• Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam & Trøseid, Marius (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-25168-3 Fulltekst i vitenarkiv.
• Hoffmann-Vold, Anna-Maria; Hesselstrand, Roger; Fretheim, Håvard Halland; Ueland, Thor; Andreassen, Arne K.; Brunborg, Cathrine; Palchevskiy, Vyacheslav; Midtvedt, Øyvind; Garen, Torhild Oddveig; Aukrust, Pål; Belperio, John A & Molberg, Øyvind (2018). CCL21 as a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis & Rheumatology.  ISSN 2326-5191.  70(10), s 1644- 1653 . doi: 10.1002/art.40534
• Hoffmann-Vold, Anna-Maria; Weigt, Stefan; Palchevskiy, Vyacheslav; Volkmann, Elizabeth R.; Saggar, Rajan; Li, Ning; Midtvedt, Øyvind; Lund, May-Brith; Garen, Torhild Oddveig; Fishbein, Michael C; Ardehali, Abbas; Ross, David J.; Ueland, Thor; Aukrust, Pål; Lynch, Joseph P; Elashoff, Robert M.; Molberg, Øyvind & Belperio, John A (2018). Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis. PLoS ONE.  ISSN 1932-6203.  13(11), s 1- 15 . doi: 10.1371/journal.pone.0206545 Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Fulltekst i vitenarkiv.
• Jørgensen, Silje Fjellgård; Fevang, Børre & Aukrust, Pål (2018). Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications. Journal of Clinical Immunology.  ISSN 0271-9142.  39(1), s 30- 36 . doi: 10.1007/s10875-018-0574-z
• Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Melberg, Tor Harald; Skadberg, Øyvind; Bergseth, Rolf; Selvåg, Jone; Auestad, Bjørn Henrik; Aukrust, Pål; Aarsland, Torbjørn & Ørn, Stein (2018). High physical fitness is associated with reduction in basal and exercise induced inflammation. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  28(1), s 172- 179 . doi: 10.1111/sms.12878
• Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål & Damås, Jan Kristian (2018). Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  271, s 1- 7 . doi: 10.1016/j.ijcard.2018.04.136 Fulltekst i vitenarkiv.
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Ueland, Thor; Michelsen, Annika; Pettersen, Kjell; Aukrust, Pål; Mørkrid, Lars; Gullestad, Lars & Broch, Kaspar (2018). Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis. Open heart.  ISSN 2053-3624.  5:e000901(2), s 1- 10 . doi: 10.1136/openhrt-2018-000901 Fulltekst i vitenarkiv.
• Lekva, Tove; Godang, Kristin; Michelsen, Annika; Qvigstad, Elisabeth; Normann, Kjersti Ringvoll; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Roland, Marie Cecilie & Ueland, Thor (2018). Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation. Scientific Reports.  ISSN 2045-2322.  8:13392, s 1- 9 . doi: 10.1038/s41598-018-31614-z Fulltekst i vitenarkiv.
• Mayerhofer, Christiane Caroline; Awoyemi, Ayodeji Olawale; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund; Aukrust, Pål; Hovland, Anders; Lorenzo, Andrea; Halvorsen, Sigrun; Seljeflot, Ingebjørg; Gullestad, Lars; Trøseid, Marius & Broch, Kaspar (2018). Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial. ESC Heart Failure.  ISSN 2055-5822.  5, s 978- 985 . doi: 10.1002/ehf2.12332 Fulltekst i vitenarkiv.
• Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari; Olsen, Maria Belland; Kong, Xiang Yi; Gude, Einar; Andreassen, Arne K.; Solbu, Dag; Karason, Kristjan; Dellgren, Göran; Gullestad, Lars; Aukrust, Pål & Ueland, Thor (2018). Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression. American Journal of Transplantation.  ISSN 1600-6135.  s 1- 11 . doi: 10.1111/ajt.15141 Fulltekst i vitenarkiv. Vis sammendrag

  Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1.

• Nymo, Ståle Haugset; Hartford, Marianne; Ueland, Thor; Yndestad, Arne; Lorentzen, Erik; Truvé, Katarina; Karlsson, Thomas; Ravn-Fischer, Annica; Aukrust, Pål & Caidahl, Kenneth (2018). Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome. International Journal of Cardiology.  ISSN 0167-5273.  262, s 79- 84 . doi: 10.1016/j.ijcard.2018.03.028
• Oma, Ingvild; Olstad, Ole Kristoffer; Andersen, Jacqueline Kirsti; Lyberg, Torstein; Molberg, Øyvind; Fostad, Ida; Fagerland, Morten; Almdahl, Sven Martin; Rynning, Stein Erik; Yndestad, Arne; Aukrust, Pål; Whist, Jon Elling & Hollan, Ivana (2018). Differential expression of Vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis. PLoS ONE.  ISSN 1932-6203.  13:e0202346(8), s 1- 13 . doi: 10.1371/journal.pone.0202346 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve Guttorm; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Øystein; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock. ESC Heart Failure.  ISSN 2055-5822.  5(3), s 292- 301 . doi: 10.1002/ehf2.12266 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas & Mollnes, Tom Eirik (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in Immunology.  ISSN 1664-3224.  9 . doi: 10.3389/fimmu.2018.02035 Fulltekst i vitenarkiv.
• Orrem, Hilde Lang; Shetelig, Christian; Ueland, Thor; Limalanathan, Shanmuganathan; Nilsson, Per; Husebye, Trygve Guttorm; Aukrust, Pål; Seljeflot, Ingebjørg; HOFFMANN, PAVEL; Eritsland, Jan; Mollnes, Tom Eirik; Andersen, Geir Øystein & Yndestad, Arne (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  268, s 187- 192 . doi: 10.1016/j.ijcard.2018.05.032 Fulltekst i vitenarkiv.
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Fevang, Børre; Aukrust, Pål; Langeland, Nina & Ueland, Thor (2018). Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria. BMC Infectious Diseases.  ISSN 1471-2334.  18 . doi: 10.1186/s12879-018-3593-8 Fulltekst i vitenarkiv. Vis sammendrag

  BACKGROUND: The immune response during P. falciparum infection is a two-edged sword, involving dysregulation of the inflammatory responses with several types of immune cells participating. Here we examined T-cell, monocyte/macrophage and neutrophil activation during P. falciparum infection by using soluble activation markers for these leukocyte subsets. METHODS: In a prospective cross-sectional study clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) co-infection with HIV-1, as well as HIV-infected patients with similar symptoms but without malaria (n = 58) and healthy controls (n = 52). Soluble (s)CD25, sCD14, sCD163 and myeloperoxidase (MPO) as markers for T-cell, monocyte/macrophage and neutrophil activation, respectively as well as CX3CL1, granzyme B and TIM-3 as markers of T-cell subsets and T-cell exhaustion, were analyzed. RESULTS: All patient groups had raised levels of activation markers compared with healthy controls. Levels of sCD25 and MPO increased gradually from patient with HIV only to patient with malaria only, with the highest levels in the HIV/malaria group. In the malaria group as a whole, MPO, sCD14 and in particular sCD25 were correlated with disease severity. sCD163, sCD25 and in particular MPO correlated with the degree of parasitemia as assessed by qPCR. Patients with falciparum malaria also had signs of T-cell subset activation (i.e. increased granzyme B and CX3CL1) and T-cell exhaustion as assessed by high levels of TIM-3 particularly in patients co-infected with HIV. CONCLUSION: Our data support a marked immune activation in falciparum malaria involving all major leukocyte subsets with particular enhanced activation of neutrophils and T-cells in patients co-infected with HIV. Our findings also support a link between immune activation and immune exhaustion during falciparum malaria, particularly in relation to T-cell responses in patients co-infected with HIV

• Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik & Dyrhol-Riise, Anne Ma (2018). High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections. Journal of Neuroinflammation.  ISSN 1742-2094.  15(327) . doi: 10.1186/s12974-018-1366-3 Fulltekst i vitenarkiv.
• Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2018). Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia. Open Forum Infectious Diseases.  ISSN 2328-8957.  5(2) . doi: 10.1093/ofid/ofy002 Fulltekst i vitenarkiv.
• Skarpengland, Tonje; Skjelland, Mona; Kong, Xiang Yi; Skagen, Karolina Ryeng; Holm, Sverre; Otterdal, Kari; Dahl, Christen Peder; Krohg-Sørensen, Kirsten; Sagen, Ellen Lund; Bjerkeli, Vigdis; Aamodt, Anne Hege; Abbas, Azhar; Gregersen, Ida; Aukrust, Pål; Halvorsen, Bente & Dahl, Tuva Børresdatter (2018). Increased levels of lectin-like oxidized low-density lipoprotein receptor-1 in ischemic stroke and transient ischemic attack. Journal of the American Heart Association.  ISSN 2047-9980.  7:e006479(2), s 1- 16 . doi: 10.1161/JAHA.117.006479 Fulltekst i vitenarkiv.
• Sokolova, Marina; Sahraoui, Afaf; Høyem, Merete; Øgaard, Jonas; Lien, Egil; Aukrust, Pål; Yndestad, Arne; Ranheim, Trine & Scholz, Hanne (2018). NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  315(5), s E912- E923 . doi: 10.1152/ajpendo.00461.2017
• Steineger, Johan Edvard; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Osnes, Terje; Heimdal, Ketil Riddervold & Dheyauldeen, Sinan (2018). Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis. The Laryngoscope.  ISSN 0023-852X.  129(1), s E44- E49 . doi: 10.1002/lary.27548
• Traaen, Gunn Marit; Aakerøy, Lars; Hunt, Tove Elisabeth F.; Øverland, Britt; Lyseggen, Erik; Aukrust, Pål; Ueland, Thor; Helle-Valle, Thomas Michael; Steinshamn, Sigurd Loe; Edvardsen, Thor; Zare, Hasse Khiabani; Aakhus, Svend; Akre, Harriet; Anfinsen, Ole-Gunnar; Loennechen, Jan Pål & Gullestad, Lars (2018). Treatment of sleep apnea in patients with paroxysmal atrial fibrillation: design and rationale of a randomized controlled trial. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  52(6), s 372- 377 . doi: 10.1080/14017431.2019.1567933
• Trøseid, Marius; Nordøy, Ingvild; Fevang, Børre & Aukrust, Pål (2018). Anbud på hivlegemidler er ikke faglig begrunnet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(20), s 1- 3 . doi: 10.4045/tidsskr.18.0808
• Ueland, Thor; Gullestad, Lars; Kou, Lei; Aukrust, Pål; Anand, Inder S.; Nordlund, Marianne Sparby; McMurray, John J.; van Veldhuisen, Dirk J.; Warren, David & Bolstad, Nils (2018). Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study. ESC Heart Failure.  ISSN 2055-5822.  s 1- 8 . doi: 10.1002/ehf2.12312 Fulltekst i vitenarkiv.
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente & Yndestad, Arne (2018). Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction. Open heart.  ISSN 2053-3624.  5(2) . doi: 10.1136/openhrt-2017-000765 Fulltekst i vitenarkiv.
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne & Halvorsen, Bente (2018). Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  274, s 348- 350 . doi: 10.1016/j.ijcard.2018.06.093
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic & Wallentin, Lars (2018). Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American Heart Association.  ISSN 2047-9980.  7(2) . doi: 10.1161/JAHA.117.007009 Fulltekst i vitenarkiv.
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Fulltekst i vitenarkiv.
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar & Ueland, Thor (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-03625-9 Fulltekst i vitenarkiv.
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika; Ranheim, Trine; Alfsnes, Katrine; Fiane, Arnt E; Aakhus, Svend; Lunde, Ida Gjervold; Dahl, Christen Peder; Aukrust, Pål; Christensen, Geir Arve; Gullestad, Lars; Yndestad, Arne & Ueland, Thor (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine.  ISSN 0946-2716.  95(7), s 767- 777 . doi: 10.1007/s00109-017-1529-1
• Auensen, Andreas; Hussain, Amjad; Falk, Ragnhild Sørum; Walle-Hansen, Marte Meyer; Bye, Jorun Merete; Pettersen, Kjell; Aukrust, Pål; Ueland, Thor & Gullestad, Lars (2017). Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis. PLoS ONE.  ISSN 1932-6203.  12:e0179304(6), s 1- 14 . doi: 10.1371/journal.pone.0179304 Fulltekst i vitenarkiv.
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.. Journal of Immunology.  ISSN 0022-1767.  199(8), s 2910- 2920 . doi: 10.4049/jimmunol.1700302 Fulltekst i vitenarkiv. Vis sammendrag

  Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect on CC via suppression of the inflammasome and liver X receptor activation. The putative effects of BCD on CC-induced complement activation remain unknown. In this study, we found that BCD bound to CC and reduced deposition of Igs, pattern recognition molecules, and complement factors on CC in human plasma. Furthermore, BCD decreased complement activation as measured by terminal complement complex and lowered the expression of complement receptors on monocytes in whole blood in response to CC exposure. In line with this, BCD also reduced reactive oxygen species formation caused by CC in whole blood. Furthermore, BCD attenuated the CC-induced proinflammatory cytokine responses (e.g., IL-1α, MIP-1α, TNF, IL-6, and IL-8) as well as regulated a range of CC-induced genes in human PBMC. BCD also regulated complement-related genes in human carotid plaques treated ex vivo. Formation of terminal complement complex on other complement-activating structures such as monosodium urate crystals and zymosan was not affected by BCD. These data demonstrate that BCD inhibits CC-induced inflammatory responses, which may be explained by BCD-mediated attenuation of complement activation. Thus, these findings support the potential for using BCD in treatment of atherosclerosis.

• Bermudez, Beatriz; Dahl, Tuva Børresdatter; Medina, Indira; Groeneweg, Mathijs; Holm, Sverre; Montserrat-De La Paz, Sergio; Rousch, Mat; Otten, Jeroen; Hérias, Veronica; Varela, Lourdes M.; Ranheim, Trine; Yndestad, Arne; Ortega-Gomez, Almudena; Abia, Rocio; Nagy, Laszlo; Aukrust, Pål; Muriana, Francisco J.G.; Halvorsen, Bente & Biessen, Erik Anna Leonardus (2017). Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPARγ-dependent monocyte differentiation and function. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  37(6), s 1157- 1167 . doi: 10.1161/ATVBAHA.116.308187
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia. Atherosclerosis.  ISSN 0021-9150.  256 . doi: 10.1016/j.atherosclerosis.2016.11.031
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Data on circulating leukocyte subpopulations and inflammatory proteins in children with familial hypercholesterolemia and healthy children. Data in Brief.  ISSN 2352-3409.  10, s 587- 592 . doi: 10.1016/j.dib.2016.12.042
• Christensen, Jacob J.; Ulven, Stine Marie; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin Prøven; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study. Atherosclerosis.  ISSN 0021-9150.  266, s 48- 57 . doi: 10.1016/j.atherosclerosis.2017.09.021
• Dhondup, Yangchen; Sjaastad, Ivar; Sandanger, Øystein; Aronsen, Jan Magnus; Ahmed, Muhammad Shakil; Attramadal, Håvard; Finsen, Alexandra; Zhang, Lili; Ranheim, Trine; Alfsnes, Katrine; Aukrust, Pål; Christensen, Geir Arve; Yndestad, Arne & Vinge, Leif Erik (2017). Toll-like receptor 9 promotes survival in SERCA2a KO heart failure mice. Mediators of Inflammation.  ISSN 0962-9351.  2017:9450439, s 1- 11 . doi: 10.1155/2017/9450439 Fulltekst i vitenarkiv.
• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Bjerve, Kristian S; Michelsen, Annika; Aukrust, Pål; Schmidt, EB; Christensen, JH & Jenssen, Trond Geir (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition.  ISSN 1051-2276.  27(3), s 161- 168 . doi: 10.1053/j.jrn.2016.09.008 Vis sammendrag

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Gregersen, Ida; Sandanger, Øystein; Askevold, Erik Tandberg; Sagen, Ellen Lund; Yang, Kuan; Holm, Sverre; Pedersen, Turid Margrethe; Skjelland, Mona; Krohg-Sørensen, Kirsten; Hansen, Trond Vidar; Dahl, Tuva Børresdatter; Otterdal, Kari; Espevik, Terje; Aukrust, Pål; Yndestad, Arne & Halvorsen, Bente (2017). Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.. PLoS ONE.  ISSN 1932-6203.  12(11) . doi: 10.1371/journal.pone.0188387 Fulltekst i vitenarkiv.
• Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge; Ivanauskiene, Kristina; Collas, Philippe; Shaposhnikov, Sergey; Collins, Andrew Richard; Indrevær, Randi Larsen; Aukrust, Pål; Fevang, Børre & Blomhoff, Heidi Kiil (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLoS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185708 Fulltekst i vitenarkiv.
• Holte, Espen; Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Broch, Kaspar; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Aakhus, Svend; Damås, Jan Kristian; Gullestad, Lars; Aukrust, Pål & Wiseth, Rune (2017). Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction. Heart.  ISSN 1355-6037.  103(19), s 1521- 1527 . doi: 10.1136/heartjnl-2016-310875
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Fulltekst i vitenarkiv.
• Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål; Berge, Rolf Kristian; Nielsen, Erik Waage; Retterstøl, Kjetil & Lappegård, Knut Tore (2017). Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  77(8), s 628- 633 . doi: 10.1080/00365513.2017.1393691 Fulltekst i vitenarkiv.
• Kiani, Adnan; Aukrust, Pål; Ueland, Thor; Hollan, Ivana; Barr, Elizabeth L.M.; Magder, Laurence S. & Petri, Michelle (2017). Serum osteoprotegrin (OPG) in subclinical atherosclerosis in systemic lupus erythematosus. Lupus.  ISSN 0961-2033.  26(8), s 865- 870 . doi: 10.1177/0961203316682101 Vis sammendrag

  INTRODUCTION: Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is strongly related to vascular calcification. We determined the association of this biomarker with subclinical atherosclerosis in systemic lupus erythematous (SLE). METHODS: We measured OPG and markers of subclinical atherosclerosis (coronary artery calcium (CAC), carotid intima-media thickness (cIMT) carotid plaque) in 166 SLE patients (91% female, 64% Caucasian, 31% African American, 5% others, mean age 45 years). Subgroups of patients with different levels of OPG level were compared with respect to average levels of CAC, cIMT, and with respect to presence of carotid plaque. Age was adjusted for using multiple regression. RESULTS: OPG was highly correlated with age (p < 0.0001). Individuals with higher levels of OPG tended to have higher measures of CAC, cIMT, and more carotid plaque. However, after adjustment for age, these associations, while still positive, were no longer statistically significant. CONCLUSION: In our study much of the association observed was due to confounding by age, and after adjusting for age, our findings do not rule out the possibility of a null association

• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology.  ISSN 1475-2840.  16:5(1), s 1- 10 . doi: 10.1186/s12933-016-0492-4 Fulltekst i vitenarkiv.
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Roland, Marie Cecilie; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up. Diabetes & vascular disease research.  ISSN 1479-1641.  14(6), s 525- 533 . doi: 10.1177/1479164117728011
• Lekva, Tove; Roland, Marie Cecilie; Michelsen, Annika; Friis, Camilla Margrethe; Aukrust, Pål; Bollerslev, Jens; Henriksen, Tore & Ueland, Thor (2017). Large reduction in adiponectin during pregnancy is associated with large-for-gestational-age newborns. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(7), s 2552- 2559 . doi: 10.1210/jc.2017-00289
• Mayerhofer, Christiane Caroline; Ueland, Thor; Broch, Kaspar; Vincent, Royce P.; Cross, Gemma F.; Dahl, Christen Peder; Aukrust, Pål; Gullestad, Lars; Hov, Johannes Espolin Roksund & Trøseid, Marius (2017). Increased secondary/primary bile acid ratio in chronic heart failure. Journal of Cardiac Failure.  ISSN 1071-9164.  23(9), s 666- 671 . doi: 10.1016/j.cardfail.2017.06.007 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(4), s 400- 408 . doi: 10.1111/acps.12783
• Niyonzima, Nathalie; Halvorsen, Bente; Sporsheim, Bjørnar; Garred, Peter; Aukrust, Pål; Mollnes, Tom Eirik & Espevik, Terje (2017). Complement activation by cholesterol crystals triggers a subsequent cytokine response. Molecular Immunology.  ISSN 0161-5890.  84, s 43- 50 . doi: 10.1016/j.molimm.2016.09.019
• Norum, Hilde Margrethe; Broch, Kaspar; Michelsen, Annika; Lunde, Ida Gjervold; Lekva, Tove; Abraityte, Judita Aurelija; Dahl, Christen Peder; Fiane, Arnt E; Andreassen, Arne K.; Christensen, Geir Arve; Aakhus, Svend; Aukrust, Pål; Gullestad, Lars & Ueland, Thor (2017). The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy. Journal of Cardiovascular Translational Research.  ISSN 1937-5387.  s 1- 10 . doi: 10.1007/s12265-017-9748-y
• Nymo, Ståle Haugset; Aukrust, Pål; Kjekshus, John; McMurray, John J.V.; Cleland, John G.F.; Wikstrand, John; Muntendam, Pieter; Wienhues-Thelen, Ursula-Henrike; Latini, Roberto; Askevold, Erik Tandberg; Gravning, Jørgen A.; Dahl, Christen Peder; Broch, Kaspar; Yndestad, Arne; Gullestad, Lars & Ueland, Thor (2017). Limited added value of circulating inflammatory biomarkers in chronic heart failure. JACC. Heart failure.  ISSN 2213-1779.  5(4), s 256- 264 . doi: 10.1016/j.jchf.2017.01.008
• Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar & Finsen, Alexandra (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports.  ISSN 2211-1247.  18, s 82- 92 . doi: 10.1016/j.celrep.2016.12.009 Fulltekst i vitenarkiv.
• Retterstøl, Kjetil; Narverud, Ingunn; Selmer, Randi; Berge, Knut Erik; Osnes, Ingvild; Ulven, Stine Marie; Halvorsen, Bente; Aukrust, Pål; Holven, Kirsten Bjørklund & Iversen, Per Ole (2017). Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics. Lipids in Health and Disease.  ISSN 1476-511X.  16 . doi: 10.1186/s12944-017-0511-9 Fulltekst i vitenarkiv.
• Schlums, Heinrich; Jung, Moonjung; Han, Hongya; Theorell, Jakob; Bigley, Venetia; Chiang, Samuel C.C.; Allan, David S J; Davidson-Moncada, Jan K; Dickinson, Rachel E; Holmes, Tim; Hsu, Amy P; Townsley, D.; Winkler, Thomas; Wang, Weixin; Aukrust, Pål; Nordøy, Ingvild; Calvo, Katherine R.; Holland, Steve; Collin, Matthew; Dunbar, Cynthia E & Bryceson, Yenan (2017). Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood.  ISSN 0006-4971.  129(14), s 1927- 1939 . doi: 10.1182/blood-2016-08-734236
• Shahini, Negar; Michelsen, Annika; Nilsson, Per; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen Peder; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne & Louwe, Maria Cornelia (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep42532 Fulltekst i vitenarkiv.
• Shetelig, Christian; Shanmuganathan, Limalanathan; Eritsland, Jan; HOFFMANN, PAVEL; Seljeflot, Ingebjørg; Gran, Jon Michael; Aukrust, Pål; Ueland, Thor & Andersen, Geir Øystein (2017). Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function. PLoS ONE.  ISSN 1932-6203.  12:e0173034(3), s 1- 14 . doi: 10.1371/journal.pone.0173034 Fulltekst i vitenarkiv.
• Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik & Heggelund, Lars (2017). Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia. European Journal of Clinical Investigation.  ISSN 0014-2972.  48(1) . doi: 10.1111/eci.12865 Fulltekst i vitenarkiv.
• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen; Attramadal, Håvard; Torp, May-Kristin; Fosshaug, Linn Elisabeth Lillerud; Rashidi, Azita; Lien, Egil; Finsen, Alexandra; Sandanger, Øystein; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2017). Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(2), s 234- 245 . doi: 10.1016/j.bbalip.2016.11.003
• Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna; Myklebust, June & Fevang, Børre (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology.  ISSN 1521-6616.  175, s 69- 74 . doi: 10.1016/j.clim.2016.11.014 Vis sammendrag

  Patients with common variable immunodeficiency (CVID) constitute a clinically and immunologically heterogeneous group characterized by B-cell dysfunction with hypogammaglobulinemia and defective immunoglobulin class switch of unknown etiology. Current classification systems are insufficient to achieve precise disease management. Characterization of signaling pathways essential for B-cell differentiation and class switch could provide new means to stratify patients. We evaluated constitutive and induced signaling by phospho-specific flow cytometry in 26 CVID patients and 18 healthy blood donors. Strong responses were induced both in CVID and healthy donor B cells upon activation. In contrast, constitutive phosphorylation levels of STAT3,-5,-6, Erk, PLC-γ and Syk were significantly increased in CVID B cells only. Hierarchical clustering revealed a subgroup of CVID patients with elevated constitutive phosphorylation of Syk and PLC-γ. All these patients had non-infectious complications, indicating that a distinct phosphorylation pattern of kinases in B cells identifies a clinically important subgroup of CVID patients.

• Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene; Tasken, Kjetil; Aukrust, Pål; Myklebust, June & Olweus, Johanna (2017). Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity.  ISSN 0896-8411.  81, s 110- 119 . doi: 10.1016/j.jaut.2017.04.004
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway. European Journal of Preventive Cardiology.  ISSN 2047-4873.  24(11), s 1161- 1167 . doi: 10.1177/2047487317703826
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study. International Journal of Cardiology.  ISSN 0167-5273.  243, s 502- 504 . doi: 10.1016/j.ijcard.2017.05.106 Fulltekst i vitenarkiv.
• Welsh, Paul; Kou, Lei; Changhong, Yu; Inder, Anand; Van Veldhuisen, Dirk J; Maggioni, Aldo P; Desai, Akshay S.; Solomon, Scott D.; Pfeffer, Marc A.; Cheng, Sunfa; Gullestad, Lars; Aukrust, Pål; Ueland, Thor; Swedberg, Karl; Young, James; Kattan, Michael W.; Sattar, Naveed & McMurray, John J. V. (2017). Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study. European Journal of Heart Failure.  ISSN 1388-9842.  20(2), s 268- 277 . doi: 10.1002/ejhf.988
• Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars & Nytrøen, Kari (2017). Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients. Open heart.  ISSN 2053-3624.  4(2) . doi: 10.1136/openhrt-2017-000635 Fulltekst i vitenarkiv.
• Ahmed, Ammad; Hollan, Ivana; Curran, Samuel A.; Kitson, Susan M; Riggio, Marcello P.; Mikkelsen, Knut; Almdahl, Sven Martin; Aukrust, Pål; McInnes, Iain B. & Goodyear, Carl S (2016). Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients with Rheumatoid Arthritis. Arthritis & Rheumatology.  ISSN 2326-5191. . doi: 10.1002/art.39574
• Arain, Fizza Kanwal; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Cleland, JG; Michelsen, Annika; McMurray, JJ; Wikstrand, J; Aukrust, Pål & Ueland, Thor (2016). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA. Biomarkers.  ISSN 1354-750X.  22(3-4), s 261- 267 . doi: 10.1080/1354750X.2016.1204003
• Dhondup, Yangchen; Ueland, Thor; Dahl, Christen Peder; Askevold, Erik Tandberg; Sandanger, Øystein; Fiane, Arnt E; Ohm, Ingrid Kristine; Sjaastad, Ivar; Finsen, Alexandra; Wæhre, Anne; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne & Vinge, Leif Erik (2016). Low circulating levels of mitochondrial and high levels of nuclear DNA predict mortality in chronic heart failure. Journal of Cardiac Failure.  ISSN 1071-9164.  22(10), s 823- 828 . doi: 10.1016/j.cardfail.2016.06.013 Vis sammendrag

  Background Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the regulation of these danger-associated molecular patterns during human heart failure (HF). Methods and Results Plasma levels of mtDNA and nDNA from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain reaction and compared with controls (n = 72). Increased levels of mtDNA were found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. Kaplan-Meier analysis revealed higher mortality in patients with high nDNA levels, whereas high levels of mtDNA were associated with survival. Conclusions Plasma levels of mtDNA and nDNA are elevated in human HF associated with increased and decreased mortality, respectively. This study may suggest a rationale for exploring interventions within inflammatory signaling pathways activated by nucleic acids as novel targets in treatment of HF.

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• Jørgensen, Silje Fjellgård; Holm, Kristian; Macpherson, Magnhild Eide; Larsen, Christopher Storm; Kummen, Martin; Fevang, Børre; Aukrust, Pål & Hov, Johannes Espolin Roksund (2019). Selective IgA deficiency in humans is associated with reduced gut microbial diversity. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  143(5), s 1969- 1971.e11 . doi: 10.1016/j.jaci.2019.01.019
• Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore; Bollerslev, Jens; Espevik, Terje; Aukrust, Pål; Halvorsen, Bente & Holven, Kirsten Bjørklund (2018). Association between omega 6 fatty acids and inflammation-related gene expression in PBMCs: a cross-sectional study in healthy children.
• Fevang, Børre; Fagerli, Unn Merete; Sorte, Hanne Sørmo; Aarset, Harald; Hov, Håkon; Langmyr, Marit; Keil, Thomas; Bjørge, Ellen; Aukrust, Pål; Stray-Pedersen, Asbjørg & Gedde-Dahl, Thobias (2018). Runaway Train; A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas. Hindawi (Case Reports in Immunology). . doi: 10.1155/2018/2053716
• Sikkeland, Liv Ingunn Bjoner; Borander, Anne Katrine; Voie, Øyvind Albert; Aass, Hans Christian Dalsbotten; Øvstebø, Reidun; Aukrust, Pål; Longva, Kjetil Sager; Alexis, Neil E.; Kongerud, Johny & Ueland, Thor (2018). Systemic and Airway Inflammation After Exposure to Fumes from Military Small Arms. American Journal of Respiratory and Critical Care Medicine.  ISSN 1073-449X.  197(10), s 1349- 1353 . doi: 10.1164/rccm.201709-1857LE
• Udjus, Camilla; Cero, Fadila; Halvorsen, Bente; Aukrust, Pål; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2018). Inhibition of caspase-1 reduces hypoxia-induced pulmonary hypertension by downregulating smooth muscle cell growth.
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin inhibits CC-induced complement activation.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten B. (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Ulven, Stine M.; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin P.; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study.
• Espevik, Terje; Niyonzima, Nathalie; Bakke, Siril Skaret; Halvorsen, Bente; Gregersen, Ida; Skjelland, Mona; Yndestad, Arne; Sandanger, Øystein; Andersen, Geir Øystein; Gullestad, Lars; Latz, Eicke; Aukrust, Pål & Mollnes, Tom Eirik (2017). Systemic- and local complement activation controls the NLRP3 inflammasome pathway in patients with atherosclerosis.
• Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Aukrust, Pål; Lundin, Knut Erik Aslaksen & Fevang, Børre (2017). CVID and Celiac Disease. American Journal of Gastroenterology.  ISSN 0002-9270.  112(2), s 393- 393 . doi: 10.1038/ajg.2016.551

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