Pål Aukrust

• Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research.  ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007
• Abadpour, Shadab; Halvorsen, Bente; Sahraoui, Afaf; Korsgren, Olle; Aukrust, Pål & Scholz, Hanne (2018). Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT. Journal of Molecular Endocrinology.  ISSN 0952-5041.  60(3), s 171- 183 . doi: 10.1530/JME-17-0182
• Abraityte, Judita Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James; McMurray, John J.V.; van Veldhuisen, Dirk J.; Gullestad, Lars & Ueland, Thor (2018). T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clinical Research in Cardiology.  ISSN 1861-0684.  s 1- 9 . doi: 10.1007/s00392-018-1331-2
• Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Yndestad, Arne; Halvorsen, Bente; Brustugun, Odd Terje; Aukrust, Pål; Ueland, Thor & Helland, Åslaug (2018). Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease. BMC Cancer.  ISSN 1471-2407.  18(1) . doi: 10.1186/s12885-018-4659-0
• Ellingsen, Trygve; Lappegård, Jostein; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas & Hansen, John-Bjarne (2018). Plasma hepcidin is associated with future risk of venous thromboembolism. Blood Advances.  ISSN 2473-9537.  2(1) . doi: 10.1182/ bloodadvances.2018018465
• Heldal, Torbjørn Fossum; Ueland, Thor; Jenssen, Trond Geir; Hartmann, Anders; Reisæter, Anna Varberg; Aukrust, Pål; Michelsen, Annika & Åsberg, Anders (2018). Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study. Transplant International.  ISSN 0934-0874.  31(5), s 510- 519 . doi: 10.1111/tri.13116
• Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam & Trøseid, Marius (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports.  ISSN 2045-2322.  8:6725, s 1- 9 . doi: 10.1038/s41598-018-25168-3
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1
• Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Melberg, Tor Harald; Skadberg, Øyvind; Bergseth, Rolf; Selvåg, Jone; Auestad, Bjørn Henrik; Aukrust, Pål; Aarsland, Torbjørn & Ørn, Stein (2018). High physical fitness is associated with reduction in basal and exercise induced inflammation. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  28(1), s 172- 179 . doi: 10.1111/sms.12878
• Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål & Damås, Jan Kristian (2018). Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1? in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273. . doi: 10.1016/j.ijcard.2018.04.136
• Nymo, Ståle Haugset; Hartford, Marianne; Ueland, Thor; Yndestad, Arne; Lorentzen, Erik; Truvé, Katarina; Karlsson, Thomas; Ravn-Fischer, Annica; Aukrust, Pål & Caidahl, Kenneth (2018). Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome. International Journal of Cardiology.  ISSN 0167-5273.  262, s 79- 84 . doi: 10.1016/j.ijcard.2018.03.028
• Orrem, Hilde Lang; Shetelig, Christian; Ueland, Thor; Limalanathan, Shanmuganathan; Nilsson, Per; Husebye, Trygve Guttorm; Aukrust, Pål; Seljeflot, Ingebjørg; HOFFMANN, PAVEL; Eritsland, Jan; Mollnes, Tom Eirik; Andersen, Geir Øystein & Yndestad, Arne (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273. . doi: 10.1016/j.ijcard.2018.05.032
• Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2018). Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia. Open Forum Infectious Diseases.  ISSN 2328-8957.  5(2) . doi: 10.1093/ofid/ofy002
• Skarpengland, Tonje; Skjelland, Mona; Kong, Xiang Yi; Skagen, Karolina Ryeng; Holm, Sverre; Otterdal, Kari; Dahl, Christen Peder; Krohg-Sørensen, Kirsten; Sagen, Ellen Lund; Bjerkeli, Vigdis; Aamodt, Anne Hege; Abbas, Azhar; Gregersen, Ida; Aukrust, Pål; Halvorsen, Bente & Dahl, Tuva Børresdatter (2018). Increased levels of lectin-like oxidized low-density lipoprotein receptor-1 in ischemic stroke and transient ischemic attack. Journal of the American Heart Association.  ISSN 2047-9980.  7:e006479(2), s 1- 16 . doi: 10.1161/JAHA.117.006479 Fulltekst i vitenarkiv.
• Ueland, Thor; Gullestad, Lars; Kou, Lei; Aukrust, Pål; Anand, Inder S.; Nordlund, Marianne Sparby; McMurray, John J.; van Veldhuisen, Dirk J.; Warren, David & Bolstad, Nils (2018). Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study. ESC Heart Failure.  ISSN 2055-5822.  s 1- 8 . doi: 10.1002/ehf2.12312
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne & Halvorsen, Bente (2018). Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273. . doi: 10.1016/j.ijcard.2018.06.093
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic & Wallentin, Lars (2018). Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American Heart Association.  ISSN 2047-9980.  7(2) . doi: 10.1161/JAHA.117.007009
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar & Ueland, Thor (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-03625-9 Fulltekst i vitenarkiv.
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika; Ranheim, Trine; Alfsnes, Katrine; Fiane, Arnt E; Aakhus, Svend; Lunde, Ida Gjervold; Dahl, Christen Peder; Aukrust, Pål; Christensen, Geir Arve; Gullestad, Lars; Yndestad, Arne & Ueland, Thor (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine.  ISSN 0946-2716.  95(7), s 767- 777 . doi: 10.1007/s00109-017-1529-1
• Auensen, Andreas; Hussain, Amjad; Falk, Ragnhild Sørum; Walle-Hansen, Marte Meyer; Bye, Jorun Merete; Pettersen, Kjell; Aukrust, Pål; Ueland, Thor & Gullestad, Lars (2017). Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis. PLoS ONE.  ISSN 1932-6203.  12:e0179304(6), s 1- 14 . doi: 10.1371/journal.pone.0179304 Fulltekst i vitenarkiv.
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.. Journal of Immunology.  ISSN 0022-1767.  199(8), s 2910- 2920 . doi: 10.4049/jimmunol.1700302 Fulltekst i vitenarkiv. Vis sammendrag

  Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect on CC via suppression of the inflammasome and liver X receptor activation. The putative effects of BCD on CC-induced complement activation remain unknown. In this study, we found that BCD bound to CC and reduced deposition of Igs, pattern recognition molecules, and complement factors on CC in human plasma. Furthermore, BCD decreased complement activation as measured by terminal complement complex and lowered the expression of complement receptors on monocytes in whole blood in response to CC exposure. In line with this, BCD also reduced reactive oxygen species formation caused by CC in whole blood. Furthermore, BCD attenuated the CC-induced proinflammatory cytokine responses (e.g., IL-1α, MIP-1α, TNF, IL-6, and IL-8) as well as regulated a range of CC-induced genes in human PBMC. BCD also regulated complement-related genes in human carotid plaques treated ex vivo. Formation of terminal complement complex on other complement-activating structures such as monosodium urate crystals and zymosan was not affected by BCD. These data demonstrate that BCD inhibits CC-induced inflammatory responses, which may be explained by BCD-mediated attenuation of complement activation. Thus, these findings support the potential for using BCD in treatment of atherosclerosis.

• Bermudez, Beatriz; Dahl, Tuva Børresdatter; Medina, Indira; Groeneweg, Mathijs; Holm, Sverre; Montserrat-De La Paz, Sergio; Rousch, Mat; Otten, Jeroen; Hérias, Veronica; Varela, Lourdes M.; Ranheim, Trine; Yndestad, Arne; Ortega-Gomez, Almudena; Abia, Rocio; Nagy, Laszlo; Aukrust, Pål; Muriana, Francisco J.G.; Halvorsen, Bente & Biessen, Erik Anna Leonardus (2017). Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPARγ-dependent monocyte differentiation and function. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  37(6), s 1157- 1167 . doi: 10.1161/ATVBAHA.116.308187
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia. Atherosclerosis.  ISSN 0021-9150.  256 . doi: 10.1016/j.atherosclerosis.2016.11.031
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin Prøven; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine Marie; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Data on circulating leukocyte subpopulations and inflammatory proteins in children with familial hypercholesterolemia and healthy children. Data in Brief.  ISSN 2352-3409.  10, s 587- 592 . doi: 10.1016/j.dib.2016.12.042
• Christensen, Jacob J.; Ulven, Stine Marie; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin Prøven; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study. Atherosclerosis.  ISSN 0021-9150.  266, s 48- 57 . doi: 10.1016/j.atherosclerosis.2017.09.021
• Dhondup, Yangchen; Sjaastad, Ivar; Sandanger, Øystein; Aronsen, Jan Magnus; Ahmed, Muhammad Shakil; Attramadal, Håvard; Finsen, Alexandra; Zhang, Lili; Ranheim, Trine; Alfsnes, Katrine; Aukrust, Pål; Christensen, Geir Arve; Yndestad, Arne & Vinge, Leif Erik (2017). Toll-like receptor 9 promotes survival in SERCA2a KO heart failure mice. Mediators of Inflammation.  ISSN 0962-9351.  2017:9450439, s 1- 11 . doi: 10.1155/2017/9450439 Fulltekst i vitenarkiv.
• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Bjerve, Kristian S; Michelsen, Annika; Aukrust, Pål; Schmidt, EB; Christensen, JH & Jenssen, Trond Geir (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition.  ISSN 1051-2276.  27(3), s 161- 168 . doi: 10.1053/j.jrn.2016.09.008 Vis sammendrag

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Gregersen, Ida; Sandanger, Øystein; Askevold, Erik Tandberg; Sagen, Ellen Lund; Yang, Kuan; Holm, Sverre; Pedersen, Turid Margrethe; Skjelland, Mona; Krohg-Sørensen, Kirsten; Hansen, Trond Vidar; Dahl, Tuva Børresdatter; Otterdal, Kari; Espevik, Terje; Aukrust, Pål; Yndestad, Arne & Halvorsen, Bente (2017). Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.. PLoS ONE.  ISSN 1932-6203.  12(11) . doi: 10.1371/journal.pone.0188387 Fulltekst i vitenarkiv.
• Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge; Ivanauskiene, Kristina; Collas, Philippe; Shaposhnikov, Sergey; Collins, Andrew Richard; Indrevær, Randi Larsen; Aukrust, Pål; Fevang, Børre & Blomhoff, Heidi Kiil (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLoS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185708 Fulltekst i vitenarkiv.
• Holte, Espen; Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Broch, Kaspar; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Aakhus, Svend; Damås, Jan Kristian; Gullestad, Lars; Aukrust, Pål & Wiseth, Rune (2017). Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction. Heart.  ISSN 1355-6037.  103(19), s 1521- 1527 . doi: 10.1136/heartjnl-2016-310875
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183
• Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål; Berge, Rolf Kristian; Nielsen, Erik Waage; Retterstøl, Kjetil & Lappegård, Knut Tore (2017). Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  77(8), s 628- 633 . doi: 10.1080/00365513.2017.1393691 Fulltekst i vitenarkiv.
• Kiani, Adnan; Aukrust, Pål; Ueland, Thor; Hollan, Ivana; Barr, Elizabeth L.M.; Magder, Laurence S. & Petri, Michelle (2017). Serum osteoprotegrin (OPG) in subclinical atherosclerosis in systemic lupus erythematosus. Lupus.  ISSN 0961-2033.  26(8), s 865- 870 . doi: 10.1177/0961203316682101 Vis sammendrag

  INTRODUCTION: Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is strongly related to vascular calcification. We determined the association of this biomarker with subclinical atherosclerosis in systemic lupus erythematous (SLE). METHODS: We measured OPG and markers of subclinical atherosclerosis (coronary artery calcium (CAC), carotid intima-media thickness (cIMT) carotid plaque) in 166 SLE patients (91% female, 64% Caucasian, 31% African American, 5% others, mean age 45 years). Subgroups of patients with different levels of OPG level were compared with respect to average levels of CAC, cIMT, and with respect to presence of carotid plaque. Age was adjusted for using multiple regression. RESULTS: OPG was highly correlated with age (p < 0.0001). Individuals with higher levels of OPG tended to have higher measures of CAC, cIMT, and more carotid plaque. However, after adjustment for age, these associations, while still positive, were no longer statistically significant. CONCLUSION: In our study much of the association observed was due to confounding by age, and after adjusting for age, our findings do not rule out the possibility of a null association

• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology.  ISSN 1475-2840.  16:5(1), s 1- 10 . doi: 10.1186/s12933-016-0492-4 Fulltekst i vitenarkiv.
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Roland, Marie Cecilie; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up. Diabetes & vascular disease research.  ISSN 1479-1641.  14(6), s 525- 533 . doi: 10.1177/1479164117728011
• Lekva, Tove; Roland, Marie Cecilie; Michelsen, Annika; Friis, Camilla Margrethe; Aukrust, Pål; Bollerslev, Jens; Henriksen, Tore & Ueland, Thor (2017). Large reduction in adiponectin during pregnancy is associated with large-for-gestational-age newborns. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(7), s 2552- 2559 . doi: 10.1210/jc.2017-00289
• Mayerhofer, Christiane Caroline; Ueland, Thor; Broch, Kaspar; Vincent, Royce P.; Cross, Gemma F.; Dahl, Christen Peder; Aukrust, Pål; Gullestad, Lars; Hov, Johannes Espolin Roksund & Trøseid, Marius (2017). Increased secondary/primary bile acid ratio in chronic heart failure. Journal of Cardiac Failure.  ISSN 1071-9164.  23(9), s 666- 671 . doi: 10.1016/j.cardfail.2017.06.007 Fulltekst i vitenarkiv.
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(4), s 400- 408 . doi: 10.1111/acps.12783
• Niyonzima, Nathalie; Halvorsen, Bente; Sporsheim, Bjørnar; Garred, Peter; Aukrust, Pål; Mollnes, Tom Eirik & Espevik, Terje (2017). Complement activation by cholesterol crystals triggers a subsequent cytokine response. Molecular Immunology.  ISSN 0161-5890.  84, s 43- 50 . doi: 10.1016/j.molimm.2016.09.019
• Norum, Hilde Margrethe; Broch, Kaspar; Michelsen, Annika; Lunde, Ida Gjervold; Lekva, Tove; Abraityte, Judita Aurelija; Dahl, Christen Peder; Fiane, Arnt E; Andreassen, Arne K.; Christensen, Geir Arve; Aakhus, Svend; Aukrust, Pål; Gullestad, Lars & Ueland, Thor (2017). The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy. Journal of Cardiovascular Translational Research.  ISSN 1937-5387.  s 1- 10 . doi: 10.1007/s12265-017-9748-y
• Nymo, Ståle Haugset; Aukrust, Pål; Kjekshus, John; McMurray, John J.V.; Cleland, John G.F.; Wikstrand, John; Muntendam, Pieter; Wienhues-Thelen, Ursula-Henrike; Latini, Roberto; Askevold, Erik Tandberg; Gravning, Jørgen A.; Dahl, Christen Peder; Broch, Kaspar; Yndestad, Arne; Gullestad, Lars & Ueland, Thor (2017). Limited added value of circulating inflammatory biomarkers in chronic heart failure. JACC. Heart failure.  ISSN 2213-1779.  5(4), s 256- 264 . doi: 10.1016/j.jchf.2017.01.008
• Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar & Finsen, Alexandra (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports.  ISSN 2211-1247.  18, s 82- 92 . doi: 10.1016/j.celrep.2016.12.009 Fulltekst i vitenarkiv.
• Retterstøl, Kjetil; Narverud, Ingunn; Selmer, Randi; Berge, Knut Erik; Osnes, Ingvild; Ulven, Stine Marie; Halvorsen, Bente; Aukrust, Pål; Holven, Kirsten Bjørklund & Iversen, Per Ole (2017). Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics. Lipids in Health and Disease.  ISSN 1476-511X.  16 . doi: 10.1186/s12944-017-0511-9 Fulltekst i vitenarkiv.
• Schlums, Heinrich; Jung, Moonjung; Han, Hongya; Theorell, Jakob; Bigley, Venetia; Chiang, Samuel C.C.; Allan, David S J; Davidson-Moncada, Jan K; Dickinson, Rachel E; Holmes, Tim; Hsu, Amy P; Townsley, D.; Winkler, Thomas; Wang, Weixin; Aukrust, Pål; Nordøy, Ingvild; Calvo, Katherine R.; Holland, Steve; Collin, Matthew; Dunbar, Cynthia E & Bryceson, Yenan (2017). Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood.  ISSN 0006-4971.  129(14), s 1927- 1939 . doi: 10.1182/blood-2016-08-734236
• Shahini, Negar; Michelsen, Annika; Nilsson, Per; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen Peder; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne & Louwe, Maria Cornelia (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep42532 Fulltekst i vitenarkiv.
• Shetelig, Christian; Shanmuganathan, Limalanathan; Eritsland, Jan; HOFFMANN, PAVEL; Seljeflot, Ingebjørg; Gran, Jon Michael; Aukrust, Pål; Ueland, Thor & Andersen, Geir Øystein (2017). Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function. PLoS ONE.  ISSN 1932-6203.  12:e0173034(3), s 1- 14 . doi: 10.1371/journal.pone.0173034 Fulltekst i vitenarkiv.
• Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik & Heggelund, Lars (2017). Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia. European Journal of Clinical Investigation.  ISSN 0014-2972.  48(1) . doi: 10.1111/eci.12865 Fulltekst i vitenarkiv.
• Sokolova, Marina; Vinge, Leif Erik; Alfsnes, Katrine; Olsen, Maria Belland; Eide, Lars; Kaasbøll, Ole Jørgen; Attramadal, Håvard; Torp, May-Kristin; Fosshaug, Linn Elisabeth Lillerud; Rashidi, Azita; Lien, Egil; Finsen, Alexandra; Sandanger, Øystein; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2017). Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(2), s 234- 245 . doi: 10.1016/j.bbalip.2016.11.003
• Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna; Myklebust, June & Fevang, Børre (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology.  ISSN 1521-6616.  175, s 69- 74 . doi: 10.1016/j.clim.2016.11.014 Vis sammendrag

  Patients with common variable immunodeficiency (CVID) constitute a clinically and immunologically heterogeneous group characterized by B-cell dysfunction with hypogammaglobulinemia and defective immunoglobulin class switch of unknown etiology. Current classification systems are insufficient to achieve precise disease management. Characterization of signaling pathways essential for B-cell differentiation and class switch could provide new means to stratify patients. We evaluated constitutive and induced signaling by phospho-specific flow cytometry in 26 CVID patients and 18 healthy blood donors. Strong responses were induced both in CVID and healthy donor B cells upon activation. In contrast, constitutive phosphorylation levels of STAT3,-5,-6, Erk, PLC-γ and Syk were significantly increased in CVID B cells only. Hierarchical clustering revealed a subgroup of CVID patients with elevated constitutive phosphorylation of Syk and PLC-γ. All these patients had non-infectious complications, indicating that a distinct phosphorylation pattern of kinases in B cells identifies a clinically important subgroup of CVID patients.

• Taraldsrud, Eli; Fevang, Børre; Jørgensen, Silje Fjellgård; Moltu, Kristine; Hilden, Vera Irene; Tasken, Kjetil; Aukrust, Pål; Myklebust, June & Olweus, Johanna (2017). Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. Journal of Autoimmunity.  ISSN 0896-8411.  81, s 110- 119 . doi: 10.1016/j.jaut.2017.04.004
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway. European Journal of Preventive Cardiology.  ISSN 2047-4873.  24(11), s 1161- 1167 . doi: 10.1177/2047487317703826
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study. International Journal of Cardiology.  ISSN 0167-5273.  243, s 502- 504 . doi: 10.1016/j.ijcard.2017.05.106 Fulltekst i vitenarkiv.
• Welsh, Paul; Kou, Lei; Changhong, Yu; Inder, Anand; Van Veldhuisen, Dirk J; Maggioni, Aldo P; Desai, Akshay S.; Solomon, Scott D.; Pfeffer, Marc A.; Cheng, Sunfa; Gullestad, Lars; Aukrust, Pål; Ueland, Thor; Swedberg, Karl; Young, James; Kattan, Michael W.; Sattar, Naveed & McMurray, John J. V. (2017). Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study. European Journal of Heart Failure.  ISSN 1388-9842.  20(2), s 268- 277 . doi: 10.1002/ejhf.988
• Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars & Nytrøen, Kari (2017). Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients. Open heart.  ISSN 2053-3624.  4(2) . doi: 10.1136/openhrt-2017-000635 Fulltekst i vitenarkiv.
• Ahmed, Ammad; Hollan, Ivana; Curran, Samuel A.; Kitson, Susan M; Riggio, Marcello P.; Mikkelsen, Knut; Almdahl, Sven Martin; Aukrust, Pål; McInnes, Iain B. & Goodyear, Carl S (2016). Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients with Rheumatoid Arthritis. Arthritis & Rheumatology.  ISSN 2326-5191. . doi: 10.1002/art.39574
• Arain, Fizza Kanwal; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Cleland, JG; Michelsen, Annika; McMurray, JJ; Wikstrand, J; Aukrust, Pål & Ueland, Thor (2016). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA. Biomarkers.  ISSN 1354-750X.  22(3-4), s 261- 267 . doi: 10.1080/1354750X.2016.1204003
• Dhondup, Yangchen; Ueland, Thor; Dahl, Christen Peder; Askevold, Erik Tandberg; Sandanger, Øystein; Fiane, Arnt E; Ohm, Ingrid Kristine; Sjaastad, Ivar; Finsen, Alexandra; Wæhre, Anne; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne & Vinge, Leif Erik (2016). Low circulating levels of mitochondrial and high levels of nuclear DNA predict mortality in chronic heart failure. Journal of Cardiac Failure.  ISSN 1071-9164.  22(10), s 823- 828 . doi: 10.1016/j.cardfail.2016.06.013 Vis sammendrag

  Background Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the regulation of these danger-associated molecular patterns during human heart failure (HF). Methods and Results Plasma levels of mtDNA and nDNA from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain reaction and compared with controls (n = 72). Increased levels of mtDNA were found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. Kaplan-Meier analysis revealed higher mortality in patients with high nDNA levels, whereas high levels of mtDNA were associated with survival. Conclusions Plasma levels of mtDNA and nDNA are elevated in human HF associated with increased and decreased mortality, respectively. This study may suggest a rationale for exploring interventions within inflammatory signaling pathways activated by nucleic acids as novel targets in treatment of HF.

• Gregersen, Ida; Holm, Sverre; Dahl, Tuva Børresdatter; Halvorsen, Bente & Aukrust, Pål (2016). A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases. Expert Review of Cardiovascular Therapy.  ISSN 1477-9072.  14(3), s 391- 403 . doi: 10.1586/14779072.2016.1128828 Vis sammendrag

  Cardiovascular disease (CVD) is the leading cause of death worldwide.[ 1 ] The most common CVDs include myocardial infarction (MI), ischemic stroke and periph- eral artery diseases, which affect the heart, brain and peripheral blood vessels, respectively. These disorders are in most cases caused by atherosclerosis, a patho- genic process characterized by accumulation of lipids and immune cells in the arterial wall driven by the bidirectional interaction between lipids and inflamma- tion. High cholesterol, hypertension, smoking, diabetes and obesity are risk factors for atherosclerotic plaque development, and inflammation represents a common final pathway for these risk factors as well as being an independent driver of atherogenesis.[ 2 , 3 ] Inflammation is in principle a complex beneficial response of the host upon exposure to microbe invasion, tissue damage or other stimuli to induce elimination of the initial cause of cell injury, clear out necrotic cells and tissues damage and to induce tissue repair and re- establish tissue homeostasis. However, inflammation is also a major cause of disease, including cardiovas- cular disorders, when the inflammatory response is too strong (collateral damage) or too long (nonresolving inflammation).[ 4 ] The concept of atherosclerosis as a chronic inflammatory condition is no longer controver- sial, but the understanding of the intricate immune regulation in atherosclerotic disease is still incomplete.

• Haissman, Judith M.; Knudsen, Andreas; Hoel, Hedda B; Kjær, Andreas; Kristoffersen, Ulrik S.; Berge, Rolf Kristian; Katzenstein, Terese L.; Svardal, Asbjørn M.; Ueland, Thor; Aukrust, Pål; Lebech, Anne-Mette; Nielsen, Susanne Dam & Trøseid, Marius (2016). Microbiota-Dependent Marker TMAO Is Elevated in Silent Ischemia but Is Not Associated with First-Time Myocardial Infarction in HIV Infection. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  71(2), s 130- 136 . doi: 10.1097/QAI.0000000000000843
• Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal; Wium, Cecilie; Lattanzio, Stefano; Formoso, Gloria; Di Fulvio, Patrizia; Otterdal, Kari; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Gregersen, Ida; Stavik, Benedicte; Bjerkeli, Vigdis; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Davi, Giovanni & Aukrust, Pål (2016). LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro. Diabetologia.  ISSN 0012-186X.  59, s 2134- 2144 . doi: 10.1007/s00125-016-4036-y Fulltekst i vitenarkiv.
• Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik & Ueland, Thor (2016). Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis. Neuropsychiatric Disease and Treatment.  ISSN 1176-6328.  12, s 817- 822 . doi: 10.2147/NDT.S101925 Fulltekst i vitenarkiv. Vis sammendrag

  Introduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as a major symptom, but no change in emotional state. Methods: The diagnoses of the patients with depression were according to the International Classification of Diseases, tenth edition (F32–34 spectra). Cytokine profiles in serum and CSF were determined by multiplex analysis, including 27 cytokines, chemokines, and growth factors. Results: No differences could be found between the two groups studied regarding cytokine levels in serum or CSF except for serum interleukin (IL)-1 receptor antagonist that was lower in the depression group. There were only four high correlations (>0.4) between serum and CSF levels of the cytokines, reflecting independent synthesis and turnover in these two compartments. In the control group, fatigue was associated with increased IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor, and interferon-γ (all P<0.01). Conclusion: Patients with depression had a similar cytokine profile as nondepressive patients, both systemically and in CSF. Fatigue was associated with higher levels of some inflammatory markers in the control group. It is possible that the presence of fatigue in a large proportion of patients and controls could contribute to the lack of difference in cytokine levels between these two groups.

• Hoffmann-Vold, Anna-Maria; Tennøe, Anders Heiervang; Garen, Torhild Oddveig; Midtvedt, Øyvind; Abraityte, Judita Aurelija; Aaløkken, Trond Mogens; Samersaw-Lund, May Brit; Brunborg, Cathrine; Aukrust, Pål; Ueland, Thor & Molberg, Øyvind (2016). High level of chemokine CCL18 is associated with pulmonary function deterioration, lung fibrosis progression, and reduced survival in systemic sclerosis. Chest.  ISSN 0012-3692.  150(2), s 299- 306 . doi: 10.1016/j.chest.2016.03.004
• Holter, Jan Cato; Ueland, Thor; Jenum, Pål; Müller, Fredrik; Brunborg, Cathrine; Frøland, Stig Sophus; Aukrust, Pål; Husebye, Einar & Heggelund, Lars (2016). Risk factors for long-term mortality after hospitalization for community-acquired pneumonia: a 5-year prospective follow-up study. PLoS ONE.  ISSN 1932-6203.  11:e0148741(2) . doi: 10.1371/journal.pone.0148741 Fulltekst i vitenarkiv. Vis sammendrag

  Background Contributors to long-term mortality in patients with community-acquired pneumonia (CAP) remain unclear, with little attention paid to pneumonia etiology. We examined long-term survival, causes of death, and risk factors for long-term mortality in adult patients who had been hospitalized for CAP, with emphasis on demographic, clinical, laboratory, and microbiological characteristics. Methods Two hundred and sixty-seven consecutive patients admitted in 2008–2011 to a general hospital with CAP were prospectively recruited and followed up. Patients who died during hospital stay were excluded. Demographic, clinical, and laboratory data were collected within 48 hours of admission. Extensive microbiological work-up was performed to establish the etiology of CAP in 63% of patients. Mortality data were obtained from the Norwegian Cause of Death Registry. Cox regression models were used to identify independent risk factors for all-cause mortality. Results Of 259 hospital survivors of CAP (median age 66 years), 79 (30.5%) died over a median of 1,804 days (range 1–2,520 days). Cumulative 5-year survival rate was 72.9% (95% CI 67.4–78.4%). Standardized mortality ratio was 2.90 for men and 2.05 for women. The main causes of death were chronic obstructive pulmonary disease (COPD), vascular diseases, and malignancy. Independent risk factors for death were the following (hazard ratio, 95% CI): age (1.83 per decade, 1.47–2.28), cardiovascular disease (2.63, 1.61–4.32), COPD (2.09, 1.27–3.45), immunocompromization (1.98, 1.17–3.37), and low serum albumin level at admission (0.75 per 5g/L higher, 0.58–0.96), whereas active smoking was protective (0.32, 0.14–0.74); active smokers were younger than non-smokers (P < 0.001). Microbial etiology did not predict mortality. Conclusions Results largely confirm substantial comorbidity-related 5-year mortality after hospitalization for CAP and the impact of several well-known risk factors for death, and extend previous findings on the prognostic value of serum albumin level at hospital admission. Pneumonia etiology had no prognostic value, but this remains to be substantiated by further studies using extensive diagnostic microbiological methods in the identification of causative agents of CAP.

• Holter, Jan Cato; Ueland, Thor; Norseth, Jon; Brunborg, Cathrine; Frøland, Stig Sophus; Husebye, Einar; Aukrust, Pål & Heggelund, Lars (2016). Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort. PLoS ONE.  ISSN 1932-6203.  11(7) . doi: 10.1371/journal.pone.0158536
• Husebø, Gunnar; Bakke, Per S.; Grønseth, Rune; Hardie, Jon Andrew; Ueland, Thor; Aukrust, Pål & Eagan, Tomas Mikal (2016). Macrophage migration inhibitory factor, a role in COPD. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  311(1), s L1- L7 . doi: 10.1152/ajplung.00461.2015
• Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Frydenlund, Didrik Søli; Holm, Kristian; Paulsen, Vemund; Michelsen, Annika; Jørgensen, Kristin Kaasen; Osnes, Liv T. N.; Bratlie, Jorunn; Eide, Tor Jacob; Dahl, Christen Peder; Holter, Ellen; Tronstad, Rune Rose; Hanevik, Kurt; Brattbakk, Hans-Richard; Kaveh, Fatemeh; Fiskerstrand, Torunn; Kran, Anne-Marte Bakken; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Lundin, Knut Erik Aslaksen & Fevang, Børre (2016). A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients with Common Variable Immunodeficiency. American Journal of Gastroenterology.  ISSN 0002-9270.  111(10), s 1467- 1475 . doi: 10.1038/ajg.2016.329
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika; Osnes, Liv T. N.; Holm, Kristian; Høivik, Marte; Rashidi, Azita; Dahl, Christen Peder; Vesterhus, Mette; Halvorsen, Bente; Mollnes, Tom Eirik; Berge, Rolf Kristian; Moum, Bjørn; Lundin, Knut Erik Aslaksen; Fevang, Børre; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål & Hov, Johannes Espolin Roksund (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.  ISSN 1935-3456. . doi: 10.1038/mi.2016.18
• Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune & Gullestad, Lars (2016). Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. European Heart Journal.  ISSN 0195-668X.  37(30), s 2406- 2413 . doi: 10.1093/eurheartj/ehw171 Fulltekst i vitenarkiv.
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Røsjø, Helge; Aukrust, Pål; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut.  ISSN 0017-5749.  66(4), s 611- 619 . doi: 10.1136/gutjnl-2015-310500 Vis sammendrag

  Objective: Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulcerative colitis without liver disease. Design: We prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC and HC were randomised to an exploration panel or a validation panel, and only significant results (p<0.05, QFDR<0.20) in both panels were reported, followed by a combined comparison of all samples against UC. Results: Patients with PSC (N=85) had markedly reduced bacterial diversity compared with HC (N=263, p<0.0001), and a different global microbial composition compared with both HC (p<0.001) and UC (N=36, p<0.01). The microbiota of patients with PSC with and without IBD was similar. Twelve genera separated PSC and HC, out of which 11 were reduced in PSC. However, the Veillonella genus showed a marked increase in PSC compared with both HC (p<0.0001) and UC (p<0.02). Using receiver operating characteristic analysis, Veillonella abundance yielded an area under the curve (AUC) of 0.64 to discriminate PSC from HC, while a combination of PSC- associated genera yielded an AUC of 0.78. Conclusions: Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The Veillonella genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.

• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian & Hov, Johannes Espolin Roksund (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology journal.  ISSN 2050-6406.  5(4), s 532- 541 . doi: 10.1177/2050640616663453
• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Arain, Fizza Kanwal; Damås, Jan Kristian; Aukrust, Pål & Ueland, Thor (2016). Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway. Atherosclerosis.  ISSN 0021-9150.  244, s 188- 194 . doi: 10.1016/j.atherosclerosis.2015.11.022
• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Ueland, Thor (2016). Circulating PCSK9 and risk of myocardial infarction: The HUNT Study in Norway. JACC: Basic to Translational Science.  ISSN 2452-302X.  1(7), s 568- 575 . doi: 10.1016/j.jacbts.2016.06.007
• Lekva, Tove; Michelsen, Annika; Bollerslev, Jens; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore & Ueland, Thor (2016). Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: A 5-year follow-up study. Cardiovascular Diabetology.  ISSN 1475-2840.  15(23) . doi: 10.1186/s12933-016-0345-1
• Lekva, Tove; Norwitz, Errol R.; Aukrust, Pål & Ueland, Thor (2016). Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus. Current Diabetes Reports.  ISSN 1534-4827.  16(26) . doi: 10.1007/s11892-016-0715-9
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology.  ISSN 0306-4530.  67, s 189- 197 . doi: 10.1016/j.psyneuen.2016.02.011
• Norum, Hilde Margrethe; Gullestad, Lars; Abraityte, Judita Aurelija; Broch, Kaspar; Aakhus, Svend; Aukrust, Pål & Ueland, Thor (2016). Increased Serum Levels of the Notch Ligand DLL1 Are Associated With Diastolic Dysfunction, Reduced Exercise Capacity and Adverse Outcome in Chronic Heart Failure. Journal of Cardiac Failure.  ISSN 1071-9164.  22(3), s 218- 223 . doi: 10.1016/j.cardfail.2015.07.012
• Norum, Hilde Margrethe; Kolberg, Espen; Solhaug, Vigdis; Nordal, Kristin & Aukrust, Pål (2016). Rhabdomyolysis and capillary leak syndrome in a patient treated with topical imiquimod. International Journal of Dermatology.  ISSN 0011-9059.  55(9), s 1030- 1032 . doi: 10.1111/ijd.13255
• Nymo, Ståle Haugset; Ueland, Thor; Askevold, Erik Tandberg; Dahl, Christen Peder; Gullestad, Lars; Aukrust, Pål & Yndestad, Arne (2016). Circulating nucleosomes in chronic heart failure. International Journal of Cardiology.  ISSN 0167-5273.  203, s 742- 743 . doi: 10.1016/j.ijcard.2015.10.219
• Otterdal, Kari; Portillo, Aránzazu; Astrup, Elisabeth; Ludviksen, Judith K; Davi, Giovanni; Holm, Sverre; Santilli, Francesca; Vitale, Giustina; Raoult, Didier; Olano, Juan P.; Schjalm, Camilla; Halvorsen, Bente; Oteo, José A.; Mollnes, Tom Eirik; Aukrust, Pål & Nilsson, Per (2016). High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation. Cytokine.  ISSN 1043-4666.  83, s 269- 274 . doi: 10.1016/j.cyto.2016.05.006 Vis sammendrag

  Background The pathophysiological hallmark of Rickettsia conorii (R. conorii) infection comprises infection of endothelial cells with perivascular infiltration of T-cells and macrophages. Although interferon (IFN)-γ-induced protein 10 (IP-10)/CXCL10 is induced during vascular inflammation, data on CXCL10 in R. conorii infection is scarce. Methods Serum CXCL10 was analyzed in two cohorts of southern European patients with R. conorii infection using multiplex cytokine assays. The mechanism of R. conorii-induced CXCL10 release was examined ex vivo using human whole blood interacting with endothelial cells. Results (i) At admission, R. conorii infected patients had excessively increased CXCL10 levels, similar in the Italian (n = 32, ∼56-fold increase vs controls) and the Spanish cohort (n = 38, ∼68-fold increase vs controls), followed by a marked decrease after recovery. The massive CXCL10 increase was selective since it was not accompanied with similar changes in other cytokines. (ii) Heat-inactivated R. conorii induced a marked CXCL10 increase when whole blood and endothelial cells were co-cultured. Even plasma obtained from R. conorii-exposed whole blood induced a marked CXCL10 release from endothelial cells, comparable to the levels found in serum of R. conorii-infected patients. Bacteria alone did not induce CXCL10 production in endothelial cells, macrophages or smooth muscle cells. Conclusions We show a massive and selective serum CXCL10 response in R. conorii-infected patients, likely reflecting release from infected endothelial cells characterized by infiltrating T cells and monocytes. The CXCL10 response could contribute to T-cell infiltration within the infected organ, but the pathologic consequences of CXCL10 in clinical R. conorii infection remain to be defined.

• Otterdal, Kari; Portillo, Aránzazu; Astrup, Elisabeth; Ludviksen, Judith K; Schjalm, Camilla; Raoult, Didier; Olano, Juan Pablo; Halvorsen, Bente; Oteo Revuelta, José Antonio; Aukrust, Pål; Mollnes, Tom Eirik & Nilsson, Per (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. Clinical Microbiology and Infection.  ISSN 1198-743X.  22(8), s 734.e1- 734.e6 . doi: 10.1016/j.cmi.2016.05.010 Fulltekst i vitenarkiv.
• Palm, Øyvind; Ueland, Thor; Garen, Torhild Oddveig; Michelsen, Annika; Reiseter, Silje; Aukrust, Pål; Aaløkken, Trond Mogens & Molberg, Øyvind (2016). Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome. Clinical and Experimental Rheumatology.  ISSN 0392-856X.  34(4), s 690- 693
• Pilely, Katrine; Rosbjerg, Anne; Genster, Ninette; Gál, Peter; Pál, Gábor; Halvorsen, Bente; Holm, Sverre; Aukrust, Pål; Bakke, Siril Skaret; Sporsheim, Bjørnar; Nervik, Ingunn; Niyonzima, Nathalie; Bartels, Emil D.; Stahl, Gregory L.; Mollnes, Tom Eirik; Espevik, Terje & Garred, Peter (2016). Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis. Journal of Immunology.  ISSN 0022-1767.  196(12), s 5064- 5074 . doi: 10.4049/jimmunol.1502595 Fulltekst i vitenarkiv.
• Sandanger, Øystein; Gao, E; Ranheim, Trine; Bliksøen, Marte; Kaasbøll, Ole Jørgen; Alfsnes, Katrine; Nymo, Ståle Haugset; Rashidi, Azita; Ohm, Ingrid Kristine; Attramadal, Håvard; Aukrust, Pål; Vinge, Leif Erik & Yndestad, Arne (2016). NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  469(4), s 1012- 1020 . doi: 10.1016/j.bbrc.2015.12.051
• Santilli, Francesca; Liani, Rossella; Di Fulvio, Patrizia; Formoso, Gloria; Simeone, Paola; Tripaldi, Romina; Ueland, Thor; Aukrust, Pål & Davi, Giovanni (2016). Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus. Thrombosis and Haemostasis.  ISSN 0340-6245.  116(6), s 1089- 1099 . doi: 10.1160/TH16-06-0471
• Schurgers, Leon J.; Burgmaier, M; Ueland, Thor; Schutters, K; Aakhus, Svend; Hofstra, L.S.; Gullestad, Lars; Aukrust, Pål; Hellmich, M; Narula, J & Reutelingsperger, C.P (2016). Circulating annexin A5 predicts mortality in patients with heart failure. Journal of Internal Medicine.  ISSN 0954-6820.  279(1), s 89- 97 . doi: 10.1111/joim.12396
• Skagen, Karolina Ryeng; Trøseid, Marius; Ueland, Thor; Holm, Sverre; Abbas, Azhar; Gregersen, Ida; Kummen, Martin; Bjerkeli, Vigdis; Reier-Nilsen, Frode; Russell, David; Svardal, Asbjørn M.; Karlsen, Tom Hemming; Aukrust, Pål; Berge, Rolf Kristian; Hov, Johannes Espolin Roksund; Halvorsen, Bente & Skjelland, Mona (2016). The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  247, s 64- 69 . doi: 10.1016/j.atherosclerosis.2016.01.033

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• Sikkeland, Liv Ingunn Bjoner; Borander, Anne Katrine; Voie, Øyvind Albert; Aass, Hans Christian Dalsbotten; Øvstebø, Reidun; Aukrust, Pål; Longva, Kjetil Sager; Alexis, Neil E.; Kongerud, Johny & Ueland, Thor (2018). Systemic and Airway Inflammation After Exposure to Fumes from Military Small Arms. American Journal of Respiratory and Critical Care Medicine.  ISSN 1073-449X.  197(10), s 1349- 1353 . doi: 10.1164/rccm.201709-1857LE
• Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik & Espevik, Terje (2017). Cyclodextrin inhibits CC-induced complement activation.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne B; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Osnes, Liv T. N.; Halvorsen, Bente; Retterstøl, Kjetil; Bogsrud, Martin P.; Wium, Cecilie; Svilaas, Arne; Narverud, Ingunn; Ulven, Stine M.; Aukrust, Pål & Holven, Kirsten B. (2017). Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
• Christensen, Jacob J.; Ulven, Stine M.; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin P.; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study.
• Espevik, Terje; Niyonzima, Nathalie; Bakke, Siril Skaret; Halvorsen, Bente; Gregersen, Ida; Skjelland, Mona; Yndestad, Arne; Sandanger, Øystein; Andersen, Geir Øystein; Gullestad, Lars; Latz, Eicke; Aukrust, Pål & Mollnes, Tom Eirik (2017). Systemic- and local complement activation controls the NLRP3 inflammasome pathway in patients with atherosclerosis.
• Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Aukrust, Pål; Lundin, Knut Erik Aslaksen & Fevang, Børre (2017). CVID and Celiac Disease. American Journal of Gastroenterology.  ISSN 0002-9270.  112(2), s 393- 393 . doi: 10.1038/ajg.2016.551
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild E; Bjøro, Kristian; Karlsen, Tom Hemming; Reims, Henrik Mikael; Grzyb, Krzysztof; Fosby, Bjarte; Fevang, Børre; Aukrust, Pål & Nordøy, Ingvild (2016). Liver transplantation in patients with primary antibody deficiency. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749. . doi: 10.1016/j.jaci.2016.10.025
• Narverud, Ingunn; van Lennep, Jeanine Roeters; Christensen, Jacob J.; Versmissen, Jorie; Gran, Jon Michael; Iversen, Per Ole; Aukrust, Pål; Halvorsen, Bente; Ueland, Thor; Ulven, Stine Marie; Ose, Leiv; Veierød, Marit Bragelien; Sijbrands, Eric & Holven, Kirsten Bjørklund (2016). What is the impact of maternal inheritance of FH on lipids and CRP in children with FH?.
• Siljan, William; Holter, Jan Cato; Nymo, Ståle Haugset; Schjalm, Camilla; Müller, Fredrik; Jenum, Pål; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik & Heggelund, Lars (2016). Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome. Journal of Infection.  ISSN 0163-4453.  73(4), s 383- 386 . doi: 10.1016/j.jinf.2016.07.011

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