Ranveig Braathen

Bilde av Ranveig Braathen
English version of this page
Telefon +47 23073508
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse OUS HF Rikshospitalet Postboks 4950 Nydalen 0424 Oslo

A major challenge with development of vaccines is the “moving target”, i.e. the pathogen you want to make a vaccine against, can change over time. Influenza, COVID-19, and HIV are examples of diseases where mutations in the genome of the pathogen, allows them to evade the immune responses induced in the vaccinated individuals. Such mutations may reduce the efficiency of existing vaccines. Our research group searches to understand molecular and cellular mechanisms of the immune system. We want to explore how vaccination can train the immune system to cope with mutating pathogens. Vaccines that focus immune responses towards parts of pathogens that do not mutate as often may better protect against these pathogens over time. We use a vaccine platform, an antigen presenting cell (APC)-targeting DNA vaccine, to study various mechanisms for better immune focusing strategies to induce broadly neutralizing antibodies and T cell responses. 

 

See also our homepage at OUS: https://www.ous-research.no/braathen

Publisert 8. jan. 2021 14:43 - Sist endret 28. mai 2021 10:20