Robert Løvsletten Smith

Forsker - NORMENT part UiO
Bilde av Robert Løvsletten Smith
English version of this page
Mobiltelefon 91548286
Brukernavn
Besøksadresse Oslo Universitetssykehus HF - Ullevål Avdeling for psykoseforskning Bygg 49 0424 Oslo
Postadresse OUS, Postboks 4956 Nydalen 0424 Oslo

Foto: Kirsten Sjøwall

Faglige interesser

Primær faglig interesse er å identifisere årsaker/biomarkører til individuell variabilitet i effekt og bivirkninger av legemidler innen psykiatrien (antipsykotika, antidepressiva og stemningsstabiliserende).

Jeg er også opptatt av å implementere biomarkører innen dette området for å bedre legemiddelbehandling i klinisk praksis.

Bakgrunn

  • 2014 (år) - d.d. - Hovedarbeidsted er Senter for Psykofarmakologi, Diakonhjemmet Sykehus, hvor jeg også jobber som farmasøyt/postdoktor/veileder. Jeg er involvert i flere prosjekter der, deriblant:
    • CloZapine use and tolerability - identifying factors of treatment success (Zuccess), HSØ, biveileder stipendiat, pågående.
    • Identifying pharmacogenetic biomarkers of treatment resistant schizophrenia, HSØ, biveileder stipendiat, pågående.
    • Novel biomarkers for dose individualization and monitoring of antipsychotic drugs, biveileder stipendiat, pågående.
  • 2014 - 2022 - Gjesteforsker ved Farmasøytisk institutt, UiO
  • 2016 - 2020 - Postdoktor finansiert av HSØ med prosjekttittelen "Schizophrenia Genetics - Identifying variants associated with clozapine toxicity"
  • 2014 - Ph.d. i farmakologi, UiO
  • 2010 - MSc Pharm, UiO
Emneord: Presisjonsmedisin, legemiddelmetabolisme, legemidler, antipsykotika

Publikasjoner

  • Frederiksen, Trine; Smith, Robert Løvsletten; Jukic, Marin M. & Molden, Espen (2022). Association Between CYP2D6 Metabolizer Status and Vortioxetine Exposure and Treatment Switching: A Retrospective, Naturalistic Cohort Study Using Therapeutic Drug Monitoring Data From 640 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(4), s. 396–399. doi: 10.1097/JCP.0000000000001563.
  • Lenk, Hasan Çağın; Klöditz, Katharina; Johansson, Inger; Smith, Robert Løvsletten; Jukic, Marin & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2022). The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. doi: 10.1002/cpt.2571. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit & O'Connell, Kevin Sean [Vis alle 8 forfattere av denne artikkelen] (2022). Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronida-tion of Clozapine In vivo. Current drug metabolism. ISSN 1389-2002. 23(1), s. 66–72. doi: 10.2174/1389200223666220201152953.
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kyllesø, Lennart; Tran, Thu Thuy Anh; Tveito, Marit & Molden, Espen (2022). Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(1), s. 43–50. doi: 10.1097/JCP.0000000000001507.
  • de Leon, Leon; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Vis alle 104 forfattere av denne artikkelen] (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry. ISSN 0176-3679. s. 1–14. doi: 10.1055/a-1625-6388.
  • Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi; Seppälä, Niko & Kopeček, Miloslav [Vis alle 13 forfattere av denne artikkelen] (2021). European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(2), s. 140–147. doi: 10.1097/JCP.0000000000001341.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 750–758. doi: 10.1002/cpt.2246.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, s. 999–1008. doi: 10.1007/s40263-021-00847-4. Fulltekst i vitenarkiv
  • Frederiksen, Trine; Smith, Robert L.; Wollmann, Birgit Malene Tovik; Areberg, Johan & Molden, Espen (2021). Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-021-01029-7.
  • Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77(9), s. 1201–1208. doi: 10.1007/s00228-021-03114-z.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, s. 590–596. doi: 10.1016/j.schres.2020.11.025.
  • Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), s. 1–10. doi: 10.1038/s41398-020-00888-1. Fulltekst i vitenarkiv
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen & Høiseth, Gudrun (2020). Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77, s. 215–221. doi: 10.1007/s00228-020-03002-y. Fulltekst i vitenarkiv
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Vis alle 7 forfattere av denne artikkelen] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, s. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
  • Tveito, Marit; Molden, Espen; Høiseth, Gudrun; Correll, Christoph U. & Smith, Robert Løvsletten (2019). Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 41–49. doi: 10.1007/s00228-019-02768-0.
  • Tveito, Marit; Handal, Marte; Engedal, Knut; Smith, Robert Løvsletten; Høiseth, Gudrun & Skurtveit, Svetlana (2019). Forskrivning av antipsykotika til hjemmeboende eldre 2006–18. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(16), s. 1554–1558. doi: 10.4045/tidsskr.19.0233. Fulltekst i vitenarkiv
  • Tveito, Marit; Smith, Robert Løvsletten; Høiseth, Gudrun & Molden, Espen (2019). The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 39(6), s. 561–566. doi: 10.1097/JCP.0000000000001126.
  • Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), s. 503–508. doi: 10.1097/FTD.0000000000000619.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(5), s. 567–571. doi: 10.1097/FTD.0000000000000540.
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge & Hartberg, Cecilie Bhandari [Vis alle 8 forfattere av denne artikkelen] (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 38(6), s. 570–576. doi: 10.1097/JCP.0000000000000961.
  • Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa & Spigset, Olav [Vis alle 7 forfattere av denne artikkelen] (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs. ISSN 1172-7047. 31(11), s. 991–997. doi: 10.1007/s40263-017-0469-1.
  • Smith, Robert Løvsletten; Haslemo, Tore; Refsum, Helge & Molden, Espen (2016). Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data. European Journal of Clinical Pharmacology. ISSN 0031-6970. 72(9), s. 1099–1104. doi: 10.1007/s00228-016-2087-0.
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. Biological chemistry. ISSN 1431-6730. 396(1), s. 71–80. doi: 10.1515/hsz-2014-0172.
  • Fismen, Anne-Siri; Smith, Robert; Torsheim, Torbjørn & Samdal, Oddrun (2014). A school based study of time trends in food habits and their relation to socio-economic status among Norwegian adolescents, 2001–2009. International Journal of Behavioral Nutrition and Physical Activity. ISSN 1479-5868. 11. doi: 10.1186/s12966-014-0115-y. Fulltekst i vitenarkiv
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Atorvastatin inhibits processing, activity and secretion of legumain in macrophages. Biological chemistry. ISSN 1431-6730. 396(1), s. 71–80. doi: 10.1515/hsz-2014-0172.
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar & Solberg, Rigmor [Vis alle 8 forfattere av denne artikkelen] (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 22(13), s. 3309–3315. doi: 10.1016/j.bmc.2014.04.056.
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Vis alle 7 forfattere av denne artikkelen] (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLOS ONE. ISSN 1932-6203. 9(1:85721). doi: 10.1371/journal.pone.0085721.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Haugen, Mads Haugland; Pettersen, Solveig & Mælandsmo, Gunhild [Vis alle 8 forfattere av denne artikkelen] (2012). Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie. ISSN 0300-9084. 94(12), s. 2590–2599. doi: 10.1016/j.biochi.2012.07.026.
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Smith, Robert; Ravna, aina westrheim; Sylte, Ingebrigt & Rustan, Arild [Vis alle 8 forfattere av denne artikkelen] (2012). The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 128, s. 154–164. doi: 10.1016/j.jsbmb.2011.10.006.

Se alle arbeider i Cristin

  • de Leon, Jose; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Vis alle 104 forfattere av denne artikkelen] (2022). Erratum: Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (Pharmacopsychiatry (2022) 55 2 (73-86)). Pharmacopsychiatry. ISSN 0176-3679. 55(2). doi: 10.1055/a-1737-1527.
  • Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole [Vis alle 7 forfattere av denne artikkelen] (2020). Correction: Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits (Translational Psychiatry, (2020), 10, 1, (198), 10.1038/s41398-020-00888-1). Translational Psychiatry. ISSN 2158-3188. 10(1). doi: 10.1038/s41398-020-01061-4.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Vis alle 7 forfattere av denne artikkelen] (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor (2013). Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
  • Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert (2013). Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde & Solberg, Rigmor [Vis alle 7 forfattere av denne artikkelen] (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor (2013). The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
  • Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2013). Regulering av legumain i samspillet mellom makrofager og kreftceller.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig [Vis alle 9 forfattere av denne artikkelen] (2012). SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
  • Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?
  • Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Effects of atorvastatin on regulation of protease activities in macrophages.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig J. [Vis alle 7 forfattere av denne artikkelen] (2011). SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
  • Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor (2011). ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
  • Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2011). Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
  • Smith, Robert; carm, ellen; Nagel, Tove & Wikan, Gerd (2008). Report to Norad from an expert group on teacher education. NORAD.

Se alle arbeider i Cristin

Publisert 3. feb. 2022 14:24 - Sist endret 17. mars 2022 10:41

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