Sofie Ragnhild Aminoff

• Büchmann, Camilla Bakkalia; Pedersen, Geir Feigum; Aminoff, Sofie Ragnhild; Anderssen, Jannicke Fjæra; Barrett, Elizabeth Ann; Melle, Ingrid & Lagerberg, Trine Vik (2018). Validity of the Birchwood Insight Scale in patients with schizophrenia spectrum- and bipolar disorders. Psychiatry Research.  ISSN 0165-1781.  272, s 715- 722 . doi: doi:10.1016/j.psychres.2018.12.072 Vis sammendrag

  The aim of this study is to investigate the validity of the Norwegian version of the Insight Scale (IS) in large and representative samples of patients with schizophrenia spectrum disorders, bipolar I disorder and bipolar II disorder. A total of 997 participants were included (schizophrenia spectrum disorders: 557; bipolar I disorder: 282; bipolar II disorder: 138). Confirmatory factor analysis was conducted to investigate the construct validity and bivariate correlational analysis was applied to investigate convergent validity. Confirmatory factor analyses indicated a reasonable model fit to the original three-factor subscale structure of the IS in all three diagnostic groups. The IS total score and its subscales correlated significantly with both the insight items in the Young Mania Rating Scale and the Positive and Negative Syndrome Scale in both schizophrenia spectrum disorders and bipolar I disorder. In the bipolar II disorder group, however, the IS subscales correlated poorly with both the observer-rated measures. Our study supports the construct validity of the IS in both schizophrenia spectrum disorder- and bipolar disorder populations. The study also demonstrates that patients’ self-reports of insight correspond to observer-based single item ratings of insight in bipolar I disorder and schizophrenia spectrum disorders.

• Demmo, Christine; Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Hellvin, Tone; Simonsen, Carmen Elisabeth; Haatveit, Beathe Almenning; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2018). Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study. Bipolar Disorders.  ISSN 1398-5647.  20(3), s 228- 237 . doi: 10.1111/bdi.12569 Vis sammendrag

  OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. METHODS: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first-treatment (FT) BD I patients (N = 42), with and without relapse, during a 1-year follow-up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). RESULTS: Compared to both patients with relapse and healthy controls, no-relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no-relapse patients, reduction of symptoms was associated with neurocognitive improvement. No-relapse patients showed better global and occupational functioning. CONCLUSIONS: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow-up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery.

• Aas, Monica; Henry, C.; Bellivier, F; Lajnef, M; Gard, S; Kahn, J-P; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Bjella, Thomas; Leboyer, M; Andreassen, Ole Andreas; Melle, Ingrid & Etain, B (2017). Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  47(5), s 902- 912 . doi: 10.1017/S0033291716003081
• Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Haatveit, Beathe Christin; Andreassen, Ole Andreas; Ueland, Torill & Ueland, Torill (2017). Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study. Psychiatry Research.  ISSN 0165-1781.  249, s 286- 292 . doi: 10.1016/j.psychres.2016.12.048
• Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Pedersen, Geir Feigum; Bellivier, Frank; Icick, Romain; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2017). Alcohol use disorders are Associated With increased effective lability in bipolar disorder. Journal of Affective Disorders.  ISSN 0165-0327.  208, s 316- 324 . doi: 10.1016/j.jad.2016.09.062
• Østefjells, Tiril; Melle, Ingrid; Aminoff, Sofie Ragnhild; Hellvin, Tone; Hagen, Roger; Lagerberg, Trine Vik; Lystad, June Ullevoldsæter & Røssberg, Jan Ivar (2017). An exploration of metacognitive beliefs and thought control strategies in bipolar disorder. Comprehensive Psychiatry.  ISSN 0010-440X.  73, s 84- 92 . doi: 10.1016/j.comppsych.2016.11.008 Vis sammendrag

  Background: Previous studies have shown that individuals with schizophrenia exhibit higher levels of unhelpful metacognitive beliefs than healthy controls, but no studies have explored metacognitive beliefs in early psychosis. Aims: We examined i) differences in levels of unhelpful metacognitive beliefs between psychosis spectrum disorders, and healthy controls, and ii) to what extent demographic and clinical characteristics predicted levels of metacognitive beliefs in the early treated phases of psychotic disorders. Method: Patients were included within two years of first treatment for a psychotic disorder (N=92). They were assessed on premorbid adjustment, psychotic symptoms, anxiety/depression, and self-reported metacognitive beliefs (MCQ-30). Ninety-seven controls also completed MCQ-30. Predictors of metacognitive beliefs were explored with multiple linear regression analyses. Results: Patients scored significantly higher than controls on all metacognitive subscales except positive beliefs about worry. The regression model explained 14—38% of the variance on each metacognitive subscale. Current affective symptoms explained a significant amount of variance on all subscales, except positive beliefs about worry. Childhood (premorbid) social adjustment predicted a significant amount of the variance on all subscales, except cognitive confidence. Duration of untreated psychosis contributed significantly to more unhelpful beliefs about cognitive confidence. Negative symptoms predicted lower scores on cognitive self-consciousness. Conclusion: Affective symptoms and childhood social adjustment could be important predictors of unhelpful metacognitive beliefs in the early treated phases of psychosis, indicating potential psychopathological relationships that warrant further investigation for clinical relevance.

• Aas, Monica; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Færden, Ann; Romm, Kristin Lie; Nesvåg, Ragnar; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Agartz, Ingrid & Melle, Ingrid (2016). A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. BMC Psychiatry.  ISSN 1471-244X.  16 . doi: 10.1186/s12888-016-0827-4 Fulltekst i vitenarkiv.
• Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2016). History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first-treatment bipolar I disorder. Bipolar Disorders.  ISSN 1398-5647.  18(2), s 136- 147 . doi: 10.1111/bdi.12377
• Kvitland, Levi Røstad; Melle, Ingrid; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Ringen, Petter Andreas (2016). Cannabis use in first-treatment bipolar I disorder: Relations to clinical characteristics. Early Intervention in Psychiatry.  ISSN 1751-7885.  10(1), s 36- 44 . doi: 10.1111/eip.12138
• Kvitland, Levi Røstad; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Demmo, Christine; Hellvin, Tone; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Melle, Ingrid (2016). Duration of untreated illness in first-treatment bipolar I disorder in relation to clinical outcome and cannabis use.. Psychiatry Research.  ISSN 0165-1781.  246, s 762- 768 . doi: 10.1016/j.psychres.2016.07.064
• Aminoff, Sofie Ragnhild; Tesli, Martin Steen; Bettella, Franscesco; Aas, Monica; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2015). Polygenic risk scores in bipolar disorders subgroups. Journal of Affective Disorders.  ISSN 0165-0327.  183, s 310- 314 . doi: 10.1016/j.jad.2015.05.021
• Kaufmann, Tobias; Skåtun, Kristina Cecilie; Alnæs, Dag; Doan, Nhat Trung; Duff, Eugene; Tønnesen, Siren; Roussos, Evangelos; Ueland, Toril; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Agartz, Ingrid; Melle, Ingrid; Smith, Stephen M.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2015). Disintegration of sensorimotor brain networks in schizophrenia. Schizophrenia Bulletin.  ISSN 0586-7614.  41(6), s 1326- 1335 . doi: 10.1093/schbul/sbv060
• Kvitland, Levi Røstad; Melle, Ingrid; Aminoff, Sofie Ragnhild; Demmo, Christine; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Ringen, Petter Andreas (2015). Continued cannabis use at one year follow up is associated with elevated mood and lower global functioning in bipolar I disorder. BMC Psychiatry.  ISSN 1471-244X.  15(1) . doi: 10.1186/s12888-015-0389-x
• Aas, Monica; Pedersen, Geir Feigum; Henry, Chantal; Bjella, Thomas; Bellivier, Frank; Leboyer, Marion; Kahn, Jean-Pierre; Cohen, Renaud F.; Gard, Sebastien; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole Andreas; Melle, Ingrid & Etain, Bruno (2014). Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls. Journal of Affective Disorders.  ISSN 0165-0327.  172, s 375- 380 . doi: 10.1016/j.jad.2014.10.028
• Berg, Akiah Ottesen; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Romm, Kristin Lie; Hauff, Edvard & Melle, Ingrid (2014). The impact of immigration and visible minority status on psychosis symptom profile. Social Psychiatry and Psychiatric Epidemiology.  ISSN 0933-7954.  49(11), s 1747- 1757 . doi: 10.1007/s00127-014-0897-x Fulltekst i vitenarkiv.
• Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Aas, Monica; Ringen, Petter Andreas; Andreassen, Ole Andreas & Melle, Ingrid (2014). Indications of a dose-response relationship between cannabis use and age at onset in bipolar disorder. Psychiatry Research.  ISSN 0165-1781.  215(1), s 101- 104 . doi: 10.1016/j.psychres.2013.10.029
• Aminoff, Sofie Ragnhild; Hellvin, Tone; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Andreassen, Ole Andreas & Melle, Ingrid (2013). Neurocognitive features in subgroups of bipolar disorder. Bipolar Disorders.  ISSN 1398-5647.  15(3), s 272- 283 . doi: 10.1111/bdi.12061
• Hellvin, Tone; Sundet, Kjetil Søren; Aminoff, Sofie Ragnhild; Andreassen, Ole Andreas & Melle, Ingrid (2013). Social functioning in firste contact mania: clinical and neurocognitive correlates. Comprehensive Psychiatry.  ISSN 0010-440X.  54(5), s 432- 438 . doi: 10.1016/j.comppsych.2012.12.016
• Schøyen, Helle Kristine; Melle, Ingrid; Sundet, Kjetil Søren; Aminoff, Sofie Ragnhild; Hellvin, Tone; Auestad, Bjørn Henrik; Morken, Gunnar & Andreassen, Ole Andreas (2013). Occupational outcome in bipolar disorder is not predicted by premorbid functioning and intelligence. Bipolar Disorders.  ISSN 1398-5647.  15(3), s 294- 305 . doi: 10.1111/bdi.12056
• Aas, Monica; Steen, Nils Eiel; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Lorentzen, Steinar; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2012). Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning?. Psychiatry Research.  ISSN 0165-1781.  198(3), s 495- 500 . doi: 10.1016/j.psychres.2011.12.045
• Aminoff, Sofie Ragnhild; Jensen, Jimmy Kristian; Lagerberg, Trine Vik; Hellvin, Tone; Sundet, Kjetil Søren; Andreassen, Ole Andreas & Melle, Ingrid (2012). An association between affective lability and executive functioning in bipolar disorder. Psychiatry Research.  ISSN 0165-1781.  198(1), s 58- 61 . doi: 10.1016/j.psychres.2011.12.044
• Hellvin, Tone; Sundet, Kjetil Søren; Simonsen, Carmen Elisabeth; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Melle, Ingrid (2012). Neurocognitive functioning in patients recently diagnosed with bipolar disorder. Bipolar Disorders.  ISSN 1398-5647.  14(3), s 227- 238 . doi: 10.1111/j.1399-5618.2012.01004.x
• Aminoff, Sofie Ragnhild; Jensen, Jimmy Kristian; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Melle, Ingrid (2011). Decreased self-reported arousal in schizophrenia during aversive picture viewing compared to bipolar disorder and healthy controls. Psychiatry Research.  ISSN 0165-1781.  185(3), s 309- 314 . doi: 10.1016/j.psychres.2010.07.026
• Lagerberg, Trine Vik; Sundet, Kjetil Søren; Aminoff, Sofie Ragnhild; Berg, Akiah Ottesen; Ringen, Petter Andreas; Andreassen, Ole Andreas & Melle, Ingrid (2011). Excessive cannabis use is associated with earlier age at onset in bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.  261(6), s 397- 405 . doi: 10.1007/s00406-011-0188-4
• Larsson, Sara; Lorentzen, Steinar; Mork, Erlend; Barrett, Elisabeth Ann; Steen, Nils Eiel; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Aminoff, Sofie Ragnhild; Agartz, Ingrid; Melle, Ingrid & Andreassen, Ole Andreas (2010). Age at onset of bipolar disorder in a Norwegian catchment area sample. Journal of Affective Disorders.  ISSN 0165-0327.  124(1-2), s 174- 177 . doi: 10.1016/j.jad.2009.10.031

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• Aminoff, Sofie Ragnhild; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Melle, Ingrid; Simonsen, Carmen Elisabeth; Ueland, Torill & Aas, Monica (2015). Psykose og Samfunn. Universitetsforlaget.  ISBN 978-82-15-02469-1.  210 s.
• Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Melle, Ingrid; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Ueland, Toril & Aas, Monica (2015). Psykose og samfunn. Universitetsforlaget.  ISBN 9788215024691.  208 s.

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• Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Bjella, Thomas; Aas, Monica; Djurovic, Srdjan; Bellivier, Frank; Andreassen, Ole Andreas & Melle, Ingrid (2018). Affective lability and polygenic risk in bipolar disorder.
• Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Bellivier, Frank; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2015). Affective lability is Associated With Alcohol use disorders in Bipolar disorder.
• Aas, Monica; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Etain, Bruno; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2014). Affective lability in patients with bipolar disorders is associated with high levels of childhood trauma. Psychiatry Research.  ISSN 0165-1781.  218, s 252- 255 . doi: 10.1016/j.psychres.2014.03.046
• Aminoff, Sofie Ragnhild; Tesli, Martin Steen; Bettella, Franscesco; Aas, Monica; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2014). Polygenic risk scores in bipolar disorder subgroups.
• Kvitland, Levi Røstad; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Haram, Marit; Hellvin, Tone; Lagerberg, Trine Vik; Nerhus, Mari; Andreassen, Ole Andreas & Melle, Ingrid (2013). Cannabis use in the early phase of bipolar disorder: clinical characteristics in a cross-sectional sample. Bipolar Disorders.  ISSN 1398-5647.  15, s 118- 118

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