Thor Ueland

Bilde av Thor Ueland
English version of this page
Mobiltelefon +47-41218954
Brukernavn
Besøksadresse Sognsvannsveien 20 OUS Rikshospitalet 0372 Oslo
Postadresse Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

Group: Inflammatory biomarkers in cardiovascular and metabolic disease

Group leader: Thor Ueland

Research profile

Many disease states are associated with low-grade chronic inflammation that may result in detectable changes in inflammatory proteins that can be measured in biological fluid such as serum and plasma, making them valuable biomarkers. Measurement of these biomarkers may be therefore be useful for detecting diseases before they present and/or offer information on the mechanisms of disease, they may represent treatment targets or be helpful in evaluating treatment responses and predicting outcomes.

Our research focuses on measurement and use of inflammatory markers in different populations characterized by low-grade systemic inflammation focusing on cardiovascular disease and risk, neuropsychiatric disorders, and metabolic endocrine disease.

We have a close collaboration with the department of cardiology and analyzing inflammatory markers in blood and tissue in well characterized cross-sectional cohorts and clinical trials in patients with heart failure, acute coronary syndromes and aortic stenosis. In these studies we evaluate biomarkers, reflecting a wide range of inflammatory processes, as predictors of adverse outcome and treatment responses. A focus in these studies is investigating the impact of Wnt signaling and secreted Wnt antagonist in these conditions.

We have a close collaboration with the endocrine unit, analyzing inflammatory markers in patients characterized by growth hormone deficieny (GHD) and excess (acromegaly) as well as gluccocorticoid excess (Cushing syndrome). We also have a tight collaboration with the women and children center evaluating the impact of systemic inflammation in pregnancy on future cardiovascular and metabolic risk. These studies investigate the association between hormones and inflammatory mediators and impact on metabolic disturbances in different target tissues such as adipose tissue and bone with special focus on glucose metabolism.

We have a tight collaboration with the Psychosis Research Centre Thematically Organized Psychosis Research (TOP) group, analyzing inflammatory biomarkers in patients with schizophrenia and bipolar disorder. In these studies we focus on markers in serum/plasma as well as mRNA levels in circulating immune cells that may reflect neuroinflammation and further, investigate associations with immune-related candidate risk genes within the major histocompatibility complex, identified by genome-wide association studies (GWAS).

In addition, we have strong collaborations with other clinical research, national and international.

 

 

Publikasjoner

Se alle arbeider i Cristin

  • Gregersen, Ida; Ueland, Thor; Holter, Jan Cato; Olsen, Maria Belland; Michelsen, Annika Elisabet & Murphy, Sarah L [Vis alle 22 forfattere av denne artikkelen] (2022). CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19. Journal of Infection. ISSN 0163-4453. doi: 10.1016/j.jinf.2022.09.029.
  • Berg, Janna; Halvorsen, Ann Rita; Bengtson, May-Bente; Lindberg, Morten; Halvorsen, Bente & Aukrust, Pål [Vis alle 8 forfattere av denne artikkelen] (2022). Corrigendum: Circulating T cell activation and exhaustion markers are associated with radiation pneumonitis and poor survival in non-small-cell lung cancer, (Front. Immunol, (2022), 13, (875152), 10.3389/fimmu.2022.875152). Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.1051156.
  • Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Søraas, Arne Vasli; Fevang, Børre & Steffensen, Anne Katrine [Vis alle 14 forfattere av denne artikkelen] (2022). Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2. Viruses. ISSN 1999-4915. 14(11). doi: 10.3390/v14112420.
  • Andersen, Thomas; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Ueland, Thor & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulation 2021 (Nov. 8); 144 (Suppl. 1): A12013. Procollagen type-1 N-terminal propeptide, a collagen synthesis biomarker, is associated with adverse clinical outcome in patients with nsuspected acute coronary syndrome. .
  • Andersen, Thomas; Nilsen, Dennis W.T.; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Ueland, Thor & Aukrust, Pål [Vis alle 7 forfattere av denne artikkelen] (2021). Circulation 2021 (Nov. 8); 144 (Suppl. 1): A9149. The novel Wnt-Pathway inhibitor podogan is not associated with all-cause mortality or cardiovascular outcome in patients admitted with suspected acute coronary syndrome. .
  • Lekva, Tove; Roland, Marie Cecilie Paasche; Estensen, Mette E.; Norwitz, Errol R.; Tilburgs, Tamara & Henriksen, Tore [Vis alle 12 forfattere av denne artikkelen] (2021). Author Correction: Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence (Scientific Reports, (2021), 11, 1, (19735), 10.1038/s41598-021-99140-z). Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-00917-z.
  • Stø, Kristine; Valeur, Jørgen; Ueland, Thor; Malmstrøm, Gunn Helen; Bjerkeli, Vigdis & Kazmi, Syed Sajid Hussain [Vis alle 10 forfattere av denne artikkelen] (2021). Increased fecal levels of the SCFA butyrate may indicate poor absorption due to disrupted gut barrier in patients with carotid stenosis.
  • Narverud, Ingunn; Christensen, Jacob Juel; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2020). Profiling of immune‐related gene expression in children with familial hypercholesterolaemia.
  • Ueland, Thor; Holter, Jan Cato; Holten, Aleksander Rygh; Muller, Karl Erik; Lind, A. & Bekken, Gry Klouman [Vis alle 10 forfattere av denne artikkelen] (2020). Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure: MMP-9 and respiratory failure in COVID-19. Journal of Infection. ISSN 0163-4453. 81(3), s. e41–e43. doi: 10.1016/j.jinf.2020.06.061.
  • Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 10 forfattere av denne artikkelen] (2020). Angiopoietin-like 4 protein is a long-term predictor of outcome in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library.
  • Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 9 forfattere av denne artikkelen] (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library .
  • Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Vis alle 8 forfattere av denne artikkelen] (2020). Angiopoietin-2 is a long-term predictor of all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected acute coronary syndrome.

Se alle arbeider i Cristin

Publisert 5. juli 2012 12:51 - Sist endret 27. mai 2014 12:53