torstme

• Corniola, Marco V.; Bouthour, Walid; Vargas, Maria-Isabel & Meling, Torstein Ragnar (2020). Visual field restoration after Simpson grade I resection of symptomatic occipital lobe meningioma: illustrative case and review of the literature. Acta Neurochirurgica.  ISSN 0001-6268.  163, s 67- 71 . doi: 10.1007/s00701-020-04569-2
• Corniola, Marco V.; Lobrinus, Johannes; Lemée, Jean-Michel & Meling, Torstein Ragnar (2020). Méningiomes intracrâniens - Prise en charge des patients à l’ère microchirurgicale. Revue Medicale Suisse.  ISSN 1660-9379.  16(680), s 283- 288
• Corniola, Marco Vincenzo; Meling, Torstein Ragnar; Bijlenga, Philippe; Bernava, Gianmarco; Machi, Paolo & Schaller, Karl (2020). Posterior fossa arteriovenous malformations– experience with 14 patients and review of the literature. Central European Neurosurgery.  ISSN 2193-6315.  81(02), s 170- 176 . doi: 10.1055/s-0039-1691820
• Digernes, Ingrid; Nilsen, Line; Grøvik, Endre; Bjørnerud, Atle; Løvland, Grethe; Vik-Mo, Einar O.; Meling, Torstein Ragnar; Saxhaug, Cathrine; Helland, Åslaug; Jacobsen, Kari Dolven; Geier, Oliver & Emblem, Kyrre E (2020). Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI. Physics in Medicine and Biology.  ISSN 0031-9155.  65(22), s 225020 . doi: 10.1088/1361-6560/abb71a Fulltekst i vitenarkiv.
• Fuster i Garcia, Elies; Lorente Estellés, David; Álvarez-Torres, Maria del Mar; Juan-Albarracín, Javier; Chelebian, Eduard; Rovira, Alex; Acosta, Cristina Auger; Pineda, Jose; Oleaga, Laura; Mollà-Olmos, Enrique; Filice, Silvano; Due-Tønnessen, Paulina; Meling, Torstein Ragnar; Emblem, Kyrre Eeg & García- Gómez, Juan Miguel (2020). MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas. European Radiology.  ISSN 0938-7994. . doi: 10.1007/s00330-020-07297-4
• Hosainey, Sayied Abdol Mohieb; Lassen, Benjamin; Hald, John K; Helseth, Eirik & Meling, Torstein Ragnar (2020). The effect of tumor removal via craniotomies on preoperative hydrocephalus in adult patients with intracranial tumors. Neurosurgical review.  ISSN 0344-5607.  43(1), s 141- 151 . doi: 10.1007/s10143-018-1021-6
• Jeanmougin, Marine; Håvik, Annette Bentsen; Cekaite, Lina; Brandal, Petter; Sveen, Anita; Meling, Torstein Ragnar; Ågesen, Trude Holmeide; Scheie, David; Heim, Sverre; Lothe, Ragnhild A & Lind, Guro Elisabeth (2020). Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment. Molecular Oncology.  ISSN 1574-7891.  s 1016- 1027 . doi: 10.1002/1878-0261.12668 Fulltekst i vitenarkiv.
• König, Marton; Osnes, Terje; Bruland, Øyvind; Hall, Kirsten Sundby; Bratland, Åse & Meling, Torstein Ragnar (2020). The role of adjuvant treatment in craniofacial malignancy: A critical review. Frontiers in Oncology.  ISSN 2234-943X.  10 . doi: 10.3389/fonc.2020.01402 Fulltekst i vitenarkiv.
• Larsson, Christopher; Groote, Inge Rasmus; Vardal, Jonas; Kleppestø, Magne Mørk; Odland, Audun; Brandal, Petter; Due-Tønnessen, Paulina; Holme, Sigrun Skaar; Hope, Tuva Roaldsdatter; Meling, Torstein Ragnar; Fosse, Erik; Emblem, Kyrre E & Bjørnerud, Atle (2020). Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy. Magnetic Resonance Imaging.  ISSN 0730-725X.  68, s 106- 112 . doi: 10.1016/j.mri.2020.01.012 Fulltekst i vitenarkiv.
• Lemée, Jean-Michel; Corniola, Marco V. & Meling, Torstein Ragnar (2020). Benefits of re-do surgery for recurrent intracranial meningiomas. Scientific Reports.  ISSN 2045-2322.  10(1) . doi: 10.1038/s41598-019-57254-5 Fulltekst i vitenarkiv.
• Llorens, Anaïs; Funderud, Ingrid; Blenkmann, Alejandro Omar; Lubell, James; Foldal, Maja Dyhre; Leske, Sabine Liliana; Huster, Rene; Meling, Torstein Ragnar; Knight, Robert T; Solbakk, Anne-Kristin & Endestad, Tor (2020). Preservation of Interference Effects in Working Memory After Orbitofrontal Damage. Frontiers in Human Neuroscience.  ISSN 1662-5161.  13, s 1- 15 . doi: 10.3389/fnhum.2019.00445 Fulltekst i vitenarkiv. Vis sammendrag

  Orbitofrontal cortex (OFC) is implicated in multiple cognitive processes, including inhibitory control, context memory, recency judgment, and choice behavior. Despite an emerging understanding of the role of OFC in memory and executive control, its necessity for core working memory (WM) operations remains undefined. Here, we assessed the impact of OFC damage on interference effects in WM using a Recent Probes task based on the Sternberg item-recognition task (1966). Subjects were asked to memorize a set of letters and then indicate whether a probe letter was presented in a particular set. Four conditions were created according to the forthcoming response ("yes"/"no") and the recency of the probe (presented in the previous trial set or not). We compared behavioral and electroencephalography (EEG) responses between healthy subjects (n = 14) and patients with bilateral OFC damage (n = 14). Both groups had the same recency pattern of slower reaction time (RT) when the probe was presented in the previous trial but not in the current one, reflecting the proactive interference (PI). The within-group electrophysiological results showed no condition difference during letter encoding and maintenance. In contrast, event-related potentials (ERPs) to probes showed distinct within-group condition effects, and condition by group effects. The response and recency effects for controls occurred within the same time window (300-500 ms after probe onset) and were observed in two distinct spatial groups including right centro-posterior and left frontal electrodes. Both clusters showed ERP differences elicited by the response effect, and one cluster was also sensitive to the recency manipulation. Condition differences for the OFC group involved two different clusters, encompassing only left hemisphere electrodes and occurring during two consecutive time windows (345-463 ms and 565-710 ms). Both clusters were sensitive to the response effect, but no recency effect was found despite the behavioral recency effect. Although the groups had different electrophysiological responses, the maintenance of letters in WM, the evaluation of the context of the probe, and the decision to accept or reject a probed letter were preserved in OFC patients. The results suggest that neural reorganization may contribute to intact recency judgment and response after OFC damage.

• Meling, Torstein Ragnar & Patet, Gildas (2020). The role of EC-IC bypass in ICA blood blister aneurysms - a systematic review. Neurosurgical review.  ISSN 0344-5607.  s 1- 10 . doi: 10.1007/s10143-020-01302-6 Fulltekst i vitenarkiv.
• Meling, Trym & Meling, Torstein Ragnar (2020). The impact of surgical simulation on patient outcomes: a systematic review and meta-analysis. Neurosurgical review.  ISSN 0344-5607.  s 1- 12 . doi: 10.1007/s10143-020-01314-2 Fulltekst i vitenarkiv.
• Tønne, Elin; Due-Tønnessen, Bernt Johan; Mero, Inger-Lise; Wiig, Ulrikke Straume; Kulseth, Mari Ann; Vigeland, Magnus Dehli; Sheng, Ying; Lippe, Charlotte von der; Tveten, Kristian; Meling, Torstein Ragnar; Helseth, Eirik & Heimdal, Ketil Riddervold (2020). Benefits of clinical criteria and high-throughput sequencing for diagnosing children with syndromic craniosynostosis. European Journal of Human Genetics.  ISSN 1018-4813.  00(0), s 1- 10 . doi: 10.1038/s41431-020-00788-4 Fulltekst i vitenarkiv. Vis sammendrag

  An accurate diagnosis of syndromic craniosynostosis (CS) is important for personalized treatment, surveillance, and genetic counselling. We describe detailed clinical criteria for syndromic CS and the distribution of genetic diagnoses within the cohort. The prospective registry of the Norwegian National Unit for Craniofacial Surgery was used to retrieve individuals with syndromic CS born between 1 January 2002 and 30 June 2019. All individuals were assessed by a clinical geneticist and classified using defined clinical criteria. A stepwise approach consisting of single-gene analysis, comparative genomic hybridization (aCGH), and exome-based high-throughput sequencing, first filtering for 72 genes associated with syndromic CS, followed by an extended trio-based panel of 1570 genes were offered to all syndromic CS cases. A total of 381 individuals were registered with CS, of whom 104 (27%) were clinically classified as syndromic CS. Using the single-gene analysis, aCGH, and custom-designed panel, a genetic diagnosis was confirmed in 73% of the individuals (n = 94). The diagnostic yield increased to 84% after adding the results from the extended trio-based panel. Common causes of syndromic CS were found in 53 individuals (56%), whereas 26 (28%) had other genetic syndromes, including 17 individuals with syndromes not commonly associated with CS. Only 15 individuals (16%) had negative genetic analyses. Using the defined combination of clinical criteria, we detected among the highest numbers of syndromic CS cases reported, confirmed by a high genetic diagnostic yield of 84%. The observed genetic heterogeneity encourages a broad genetic approach in diagnosing syndromic CS.

• Tønne, Elin; Due-Tønnessen, Bernt Johan; Wiig, Ulrikke Straume; Stadheim, Barbro; Meling, Torstein Ragnar; Helseth, Eirik & Heimdal, Ketil Riddervold (2020). Epidemiology of craniosynostosis in Norway. Journal of Neurosurgery: Pediatrics.  ISSN 1933-0707.  26(1), s 68- 75 . doi: 10.3171/2020.1.PEDS2051 Fulltekst i vitenarkiv.
• Álvarez-Torres, Maria del Mar; Juan-Albarracín, Javier; Fuster i Garcia, Elies; Bellvís-Bataller, Fuensanta; Lorente, David; Reynés, Gaspar; Font de Mora, Jaime; Aparici-Robles, Fernando; Botella, Carlos; Muñoz-Langa, Jose; Faubel, Raquel; Asensio-Cuesta, Sabina; García-Ferrando, Gérman A.; Chelebian, Eduard; Auger, Cristina; Pineda, Jose; Rovira, Alex; Oleaga, Laura; Mollà-Olmos, Enrique; Revert, Antonio J.; Tshibanda, Luaba; Crisi, Girolamo; Emblem, Kyrre E; Martin, Didier; Due-Tønnessen, Paulina; Meling, Torstein Ragnar; Filice, Silvano; Sáez, Carlos & García-Gómez, Juan M. (2019). Robust association between vascular habitats and patient prognosis in glioblastoma: An international multicenter study. Journal of Magnetic Resonance Imaging.  ISSN 1053-1807.  s 1- 9 . doi: 10.1002/jmri.26958
• Blenkmann, Alejandro Omar; Collavini, Santiago; Lubell, James; Anais, Llorens; Funderud, Ingrid; Ivanovic, Jugoslav; Larsson, Pål Gunnar; Meling, Torstein Ragnar; Bekinschtein, Tristan; Kochen, Silvia; Endestad, Tor; Knight, Robert T & Solbakk, Anne-Kristin (2019). Auditory deviance detection in the human insula: An intracranial EEG study. Cortex.  ISSN 0010-9452.  121, s 189- 200 . doi: 10.1016/j.cortex.2019.09.002 Fulltekst i vitenarkiv.
• Corniola, Marco V.; Lemee, Jean-Michel; Broi, Michele Da; Joswig, Holger; Schaller, Karl; Helseth, Eirik & Meling, Torstein Ragnar (2019). Posterior fossa meningiomas: perioperative predictors of extent of resection, overall survival and progression-free survival. Acta Neurochirurgica.  ISSN 0001-6268.  161(5), s 1003- 1011 . doi: 10.1007/s00701-019-03862-z
• Corniola, Marco V.; Lemée, Jean-Michel; Schaller, Karl & Meling, Torstein Ragnar (2019). Lateral sphenoid wing meningiomas without bone invasion-still skull base surgery?. Neurosurgical review.  ISSN 0344-5607.  s 1- 7 . doi: 10.1007/s10143-019-01181-6
• König, Marton; Osnes, Terje; Bratland, Åse; Jebsen, Peter Wilhelm & Meling, Torstein Ragnar (2019). Treatment of sinonasal adenocarcinoma: A population-based prospective cohort study. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach.  ISSN 2193-6331.  61(8), s 627- 637 . doi: 10.1055/s-0039-1694050 Fulltekst i vitenarkiv.
• König, Marton; Osnes, Terje; Bratland, Åse & Meling, Torstein Ragnar (2019). Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience. Journal of Neurological Surgery. Part B: Skull Base: an interdisciplinary approach.  ISSN 2193-6331.  81(6), s 664- 672 . doi: 10.1055/s-0039-1694967 Fulltekst i vitenarkiv.
• Lemee, Jean-Michel; Corniola, Marco V.; Broi, Michele Da; Joswig, Holger; Scheie, David; Schaller, Karl; Helseth, Eirik & Meling, Torstein Ragnar (2019). Extent of Resection in Meningioma: Predictive Factors and Clinical Implications. Scientific Reports.  ISSN 2045-2322.  9(1), s 1- 6 . doi: 10.1038/s41598-019-42451-z Fulltekst i vitenarkiv. Vis sammendrag

  Meningiomas present as intracranial extra-axial lesions with dural attachment, which are primarily managed surgically. The extent of resection (EOR) may vary depending on patient- and tumor-related factors. The aim of this study is to identify preoperative predictive factors of EOR and to propose an estimation of the predicted gross total resection (GTR) based of patient- and tumor-characteristics. 1469 patients from a retrospectively (1990 to 2002) and prospectively managed (2003 to 2010) databank of Oslo University Hospital, Norway, totalling 11,414 patient-years of follow-up were included. Patients had a mean age at surgery of 64 ± 20.1 years with a female-to-male ratio was 2.4:1 and a mean KPS of 81.2 ± 12.1. Skull-base meningiomas represented 47% of all cases. WHO grades were I in 92.3%, II in 5.2%, and III in 2.2%. Bone infiltration was described in 18.7% of cases. 39.3% of patients had Simpson I resection, 34.3% had Simpson II, 5.4% had Simpson III, 20.6% had Simpson IV, and 0.5% had Simpson V. The risk factors for incomplete resection were: symptomatic presentation (OR 0.56 [0.43–0.72]), skull-base location (OR 0.79 [0.70–0.88]), and bone invasion (OR 0.85 [0.73–0.99]). Using a recursive partitioning analysis, we propose a classification-tree for the prediction of GTR rate based on preoperatively determinable patient- and tumor characteristics. The identification of preoperative predictors of poor GTR rate may aid clinicians managing meningioma patients. In selected cases were the predicted GTR rate is low, staged treatment with surgical debulking followed by adjuvant therapy may be favored in order to minimize postoperative morbidity and mortality.

• Lemee, Jean-Michel; Corniola, Marco V.; Broi, Michele Da; Schaller, Karl & Meling, Torstein Ragnar (2019). Early Postoperative Complications in Meningioma: Predictive Factors and Impact on Outcome. World Neurosurgery.  ISSN 1878-8750.  128, s 851- 858 . doi: 10.1016/j.wneu.2019.05.010 Vis sammendrag

  Background Craniotomies carry inherent risks of postoperative complications that may have a negative impact on patients' status. Recognizing and preventing surgical complications is of paramount importance, especially in meningioma surgery, where most of these tumors are benign and current management protocols are effective in terms of disease control and maintenance of higher quality of life. The objective of this study was to describe the early complications after surgery and their predictive factors in patients undergoing resection of intracranial meningiomas. Methods A partly retrospective, partly prospective review was conducted in a Norwegian population-based cohort of 1469 consecutive cases of meningioma surgery treated at the university hospitals of Oslo, totaling 11,414 patient-years of follow-up. Results 2.6% of patients had a postoperative hematoma, 2.7% a postoperative infection, 3.9% a postoperative worsening of neurologic status; 5.4% of patients died during a 30-day period after surgery. Predictive factors of increased risk of postoperative complications were patient's age for the hematoma, a non–skull base meningioma for infection, and postoperative hematoma for the risk of neurologic worsening or 30-day mortality. Conclusions Early postoperative complications in meningioma surgery have a negative impact on patient survival and postoperative neurologic status, in a disease where survival is usually not limited by the meningioma itself. In this study, we identified risk factors for early postoperative complications, the identification of at-risk populations may help to prevent the occurrence of these risk factors.

• Lemée, Jean-Michel; Joswig, Holger; Broi, Michele Da; Corniola, Marco Vincenzo; Scheie, David; Schaller, Karl; Helseth, Eirik & Meling, Torstein Ragnar (2019). WHO grade I meningiomas: classification-tree for prognostic factors of survival. Neurosurgical review.  ISSN 0344-5607.  s 1- 10 . doi: 10.1007/s10143-019-01117-0 Vis sammendrag

  World Health Organization (WHO) grade I meningiomas are intracranial extracerebral tumors, in which microsurgery as a stand-alone therapy provides high rates of disease control and low recurrence rates. Our aim was to identify prognostic factors of overall survival and time-to-retreat (OS; TTR) in a cohort of patients with surgically managed WHO grade I meningioma. Patients with WHO grade I meningiomas from a retrospectively (1990 to 2002) and prospectively managed (2003 to 2010) databank of Oslo University Hospital, Norway, were included. The mean follow-up was 9.2 ± 5.7 years, with a total of 11,414 patient-years. One thousand three hundred fifty-five patients were included. The mean age was 58 ± 13.2, mean Karnofsky Performance Status (KPS) 92.6 ± 26.1 and female-to-male ratio 2.5:1. The 1-year, 5-year, 10-year, 15-year, and 20-year probabilities were 0.98, 0.91, 0.87, 0.84, and 0.8 for TTR. Patient age (OR 0.92 [0.91, 0.94]), male sex (OR 0.59 [0.45, 0.76]), preoperative KPS ≥ 70 (OR 2.22 [1.59, 3.13]), skull base location (OR 0.77 [0.60, 1]), and the occurrence of a postoperative hematoma (OR 0.44 [0.26, 0.76]) were identified as independent prognostic factors of OS. Patient age (OR 1.02 [1.01, 1.03]) and skull base location (OR 0.30 [0.21, 0.45]) were independent predictors of decreased PFS. Using a recursive partitioning analysis, we suggest a classification tree for the prediction of 5-year PFS based on patient and tumor characteristics. The findings from this cohort of meningioma WHO I patients helps to identify patients at risk of recurrence and tailor the therapeutic management. Keywords Meningioma Overall survival Prognostic factors Time-to-retreat WHO grade I

Se alle arbeider i Cristin

• Hovden, Ivar Thokle; Geier, Oliver; Digernes, Ingrid; Fuster i Garcia, Elies; Løvland, Grethe; Vik-Mo, Einar O.; Meling, Torstein Ragnar & Emblem, Kyrre Eeg (2020). The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma. European Journal of Radiology.  ISSN 0720-048X. . doi: 10.1016/j.ejrad.2020.109278 Vis sammendrag

  Purpose Relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC)-MRI is a valuable biomarker in patients with glioblastoma for assessing treatment response and predicting overall survival. DSC-MRI based on echo planar images (EPI) may possess severe geometric distortions from magnetic field inhomogeneities up to the order of centimeters. The aim of this study is to assess how much two readily available EPI-based geometric distortion correction methods, FSL TOPUP and EPIC, affect rCBV values from DSC-MRI in patients with confirmed glioblastoma. Method We used a combined single-shot 2D gradient-echo (T2*), spin-echo (T2) EPI sequence to estimate both T2* and T2-weighted rCBV from the same contrast agent injection. Effects of distortion correction on the positive phase-encoded T2- and T2*-images were assessed in healthy anatomical brain regions in terms of Wilcoxon signed rank tests on median rCBV change and on Dice coefficients, as well as in tumor lesions in terms of Wilcoxon signed rank tests on median rCBV change. Results Our results show that following distortion correction, both gradient-echo and spin-echo rCBV increased in cortical areas of the frontal, temporal and occipital lobe, including the posterior orbital gyri in the frontal lobe and middle frontal gyri (p 

• Meling, Torstein Ragnar (2020). Cerebral bypass surgery.
• Meling, Torstein Ragnar (2020). Comprehensive Management of Vestibular Schwannoma. Acta Neurochirurgica.  ISSN 0001-6268.  10 . doi: DOI: 10.1007/s00701-017-3174-4
• Meling, Torstein Ragnar (2020). Craniopharyngiomas.
• Meling, Torstein Ragnar (2020). Cranioplasty.
• Meling, Torstein Ragnar (2020). Intra-dural tumors.
• Meling, Torstein Ragnar (2020). Microsurgical techniques: aorto-aortic termino-terminal anastomosis on rats.
• Meling, Torstein Ragnar (2020). Orbital tumors.
• Meling, Torstein Ragnar (2020). Pterional craniotomy.
• Meling, Torstein Ragnar (2020). Supratentorial decompressive craniectomy.
• Meling, Torstein Ragnar (2020). The EANS Specialist of Neurosurgery Diploma. Acta Neurochirurgica.  ISSN 0001-6268.  10 . doi: DOI: 10.1007/s00701-020-04220-0
• Meling, Torstein Ragnar (2020). The Role of Bypass Surgery in Ruptured ICA Blister-Like Aneurysms.
• Meling, Torstein Ragnar (2020). The one-layer technique for pterional craniotomy.
• Meling, Torstein Ragnar (2020). The two-layer technique for pterional craniotomy.
• Vargas, Maria Isabel; Delattre, Benedicte; Vayssiere, Pia; Corniola, Marco V. & Meling, Torstein Ragnar (2020). Intraoperative Magnetic Resonance and Synthetic Imaging. American Journal of Neuroradiology.  ISSN 0195-6108.  41(2), s E4- E6 . doi: doi:10.3174/ajnr.A6373
• Bains, Simer Jit; Niehusmann, Pitt; Meling, Torstein Ragnar; Saxhaug, Cathrine; Züchner, Mark & Brandal, Petter (2019). Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review. Acta Neurochirurgica.  ISSN 0001-6268.  161(2), s 343- 349 . doi: 10.1007/s00701-019-03800-z
• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine Liliana; Llorens, Anaïs; Funderud, Ingrid; Collavini, Santiago; Larsson, Pål Gunnar; Ivanovic, Jugoslav; Meling, Torstein Ragnar; Bekinschtein, Tristan; Kochen, Silvia; Knight, Robert T. & Endestad, Tor (2019). Human brain network involved in auditory deviance detection: Evidence from intracranial EEG recordings.
• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine Liliana; Llorens, Anaïs; Funderud, Ingrid; Collavini, Santiago; Larsson, Pål Gunnar; Ivanovic, Jugoslav; Meling, Torstein Ragnar; Bekinschtein, Tristan; Kochen, Silvia; Knight, Robert T & Endestad, Tor (2019). Human brain network involved in auditory deviance detection: Evidence from intracranial EEG recordings. Vis sammendrag

  The neural network underlying human auditory deviance detection is not fully understood. To address this, we recorded intracranial EEG from 22 adult patients with drug resistant epilepsy undergoing presurgical monitoring who had depth electrodes implanted in all brain lobes (1193 channels in total). Patients passively heard a stream of bilaterally presented tones while reading. We used the Optimum-1 paradigm, that consisted of 300 standard tones interleaved with 300 randomly presented deviant tones per block. Patients completed between 3 to 10 blocks. Deviant tones differed from standards in: 1) intensity (louder or softer), 2) frequency (higher or lower), 3) sound source location (right or left), 4) a shorter duration, or 5) a silent gap in the middle of the tone (Näätänen et al., 2004). Electrode coordinates were obtained from coregistered MRI and CT images using iElectrodes toolbox (Blenkmann et al., 2017). Channels were bipolar referenced and high frequency band activity (HFA) analytic amplitude signal was obtained using the Hilbert transform (75-145 Hz). Compared to the baseline period, significant HFA responses to tones in general were observed in 31% of the channels. We used an ANOVA to quantify the HFA response variance across trials that could be explained by the different factors of the stimuli: Intensity, Laterality, Frequency, Duration and Gap. We estimated the amount of explained variance by using ?2 (Siegel et al., 2015). Eighteen % of the channels showed a significant increase of the condition-specific explained variance. Some channels showed condition-specific activations to one particular deviant, while others showed activations to a combination of two or more deviants. The channels showing responses to tones in general and condition-specific effects were mostly observed bilaterally in temporal cortex. Frontal, anterior cingulate, and parietal cortices were also involved to a lesser extent. Our results, in line with the predictive coding framework, reveal that a distributed brain network is involved in auditory processing and deviance detection.

• Leske, Sabine Liliana; Lubell, James Isaac; Blenkmann, Alejandro Omar; Llorens, Anaïs; Funderud, Ingrid; Foldal, Maja Dyhre; Larsson, Pål Gunnar; Ivanovic, Jugoslav; Meling, Torstein Ragnar; Knight, Robert Thomas; Danielsen, Anne; Endestad, Tor & Solbakk, Anne-Kristin (2019). Auditory prediction and prediction error in self-generated tones.
• Leske, Sabine Liliana; Lubell, James; Blenkmann, Alejandro Omar; Llorens, Anaïs; Funderud, Ingrid; Foldal, Maja Dyhre; Larsson, Pål Gunnar; Ivanovic, Jugoslav; Meling, Torstein Ragnar; Knight, Robert Thomas; Danielsen, Anne; Endestad, Tor & Solbakk, Anne-Kristin (2019). Action-based auditory predictions. Vis sammendrag

  Sensory consequences of actions are predicted by the brain via an internal forward model to prepare sensory cortical areas, referred to as motor prediction. In a similar vein, the predictive coding framework suggests that perception is based on internal models making predictions about sensory events, based on statistical probabilities of the stimuli. In the current study we investigated action-based sensory predictions. We used a self-paced, two-choice random generation task, infrequently inducing deviant outcomes of voluntary action. Participants repeatedly pressed a right and a left button normatively associated with a 70 ms long 1 kHz and 2 kHz tone, respectively. Occasional deviants occurred, inverting the learned button-tone association. Participants were instructed that their button presses should be random, at a regular but self-paced tempo of one press per 1-2 s, and that they should press both buttons with equal probability. They were informed that the tones are task-irrelevant. We used intracranial EEG (iEEG) data recorded from 10 adult patients with electrodes localized in frontal and temporal lobes. The patients had drug resistant epilepsy and were undergoing presurgical monitoring via implanted stereotactic electrodes. Electrode coordinates and anatomical labels were obtained from coregistered MRI and CT images using iElectrodes toolbox. Initial results indicate that violations of action intentions modulated high frequency band activity (HFA, 75-145 Hz) in distributed brain regions including temporal and prefrontal cortices.

• Meling, Torstein Ragnar (2019). Anterior clinoidectomy - what, why & how?.
• Meling, Torstein Ragnar (2019). Anterior cranial fossa repairs.
• Meling, Torstein Ragnar (2019). Assessment of clinical outcomes of patients with multidisciplinary management of cochleo-vestibular schwannoma.
• Meling, Torstein Ragnar (2019). Brain cancer.
• Meling, Torstein Ragnar (2019). Bypass: aneurysms.
• Meling, Torstein Ragnar (2019). Bypass: aneurysms. Case presentations.
• Meling, Torstein Ragnar (2019). Craniopharyngiomas.
• Meling, Torstein Ragnar (2019). Cranioplasty.
• Meling, Torstein Ragnar (2019). Dual Pathologies: Pial Arteriovenous Fistula in Combination with an Arteiorvenous Malformation.
• Meling, Torstein Ragnar (2019). Early postoperative complications in meningioma: Predictive factors and impact on outcome.
• Meling, Torstein Ragnar (2019). Early postoperative complications in meningioma: predictive factors and impact on outcome.
• Meling, Torstein Ragnar (2019). Exploring unruptured intracranial aneurysm instability-markers in lumen morphology, dome wall aspect, and histology to improve disease-modelling.
• Meling, Torstein Ragnar (2019). Extent of resection in meningioma: predictive factors and clinical implications.
• Meling, Torstein Ragnar (2019). Frontobasal craniotomies.
• Meling, Torstein Ragnar (2019). Frontolateral Approach to the Orbit, In Andreas Raabe (ed.),  The Craniotomy Atlas.  Thieme Medical Publishers.  ISBN 9783132057913.  9.1 Frontolateral Approach to the Orbit.
• Meling, Torstein Ragnar (2019). Fronto-temporo-parietal craniotomy.
• Meling, Torstein Ragnar (2019). Giant aneurysm of the anterior circulation - How I do it.
• Meling, Torstein Ragnar (2019). Hybrid cerebrovascular surgery in the 21st century - Quo Vadis?.
• Meling, Torstein Ragnar (2019). ICA blister aneurysms.
• Meling, Torstein Ragnar (2019). ICA blister aneurysms.
• Meling, Torstein Ragnar (2019). Indications for bypass: ischemia.
• Meling, Torstein Ragnar (2019). Intracranial Aneurysms are more frequently located in the Sylvian bifurcation in Polycystic Kidney Disease patients as compared to Sporadic patients.
• Meling, Torstein Ragnar (2019). Lateral Orbitotomy, In Andreas Raabe (ed.),  The Craniotomy Atlas.  Thieme Medical Publishers.  ISBN 9783132057913.  9.2 Lateral Orbitotomy.
• Meling, Torstein Ragnar (2019). Lateral Sphenoid wing Meningiomas with bone invasion- still skull base surgery?.
• Meling, Torstein Ragnar (2019). Lumbar disc herniation - indications and surgical technique.
• Meling, Torstein Ragnar (2019). Lumbar micro-decompression.
• Meling, Torstein Ragnar (2019). Masterclass: Meningioma surgery.
• Meling, Torstein Ragnar (2019). Masterclass: Transbasal resections.
• Meling, Torstein Ragnar (2019). Meningiomas of the skull base: treatment, outcome, follow-up.
• Meling, Torstein Ragnar (2019). Microsurgical Training between Scylla and Charybdis.
• Meling, Torstein Ragnar (2019). Microsurgical techniques: aorto-aortic termino-terminal anastomosis on rats.
• Meling, Torstein Ragnar (2019). Microvascular surgery.
• Meling, Torstein Ragnar (2019). Multidisciplinary approach to patients with cervical myelopathy: Is it possible to identify the best responders to surgery?.
• Meling, Torstein Ragnar (2019). Neurosurgical Training - idir dhá thine Bhealtaine.
• Meling, Torstein Ragnar (2019). Orbital tumours.
• Meling, Torstein Ragnar (2019). Posterior fossa arteriovenous malformations - experience with 14 patients.
• Meling, Torstein Ragnar (2019). Posterior fossa lesion resection and post-operative hydrocephalus: A multicenter retrospective study for risk factor identification and state-of-art treatment methods.
• Meling, Torstein Ragnar (2019). Principles of aneurysm surgery.
• Meling, Torstein Ragnar (2019). Pterional craniotomy.
• Meling, Torstein Ragnar (2019). Pterional craniotomy - «one layer approach».
• Meling, Torstein Ragnar (2019). Rare aneurysms. What we need to know.
• Meling, Torstein Ragnar (2019). Skull base approaches in vascular neurosurgery.
• Meling, Torstein Ragnar (2019). Skull base versus skull top meningiomas.
• Meling, Torstein Ragnar (2019). Supratentorial decompressive craniectomy.
• Meling, Torstein Ragnar (2019). Surgical Simulation Training And Patient Outcomes: A Systematic Review.
• Meling, Torstein Ragnar (2019). Surgical management of CSF fistulae.
• Meling, Torstein Ragnar (2019). Surgical vs endovascular treatment for unruptured intracranial aneurysms: When to choose what?.
• Meling, Torstein Ragnar (2019). Survival and risk analysis of shunting after surgery for brain tumours in the adult population.
• Meling, Torstein Ragnar (2019). Technical and non-technical skills training by combined simulation and cadaver lab dissection: The ABC Basic Brain Course (Mi-Ge).
• Meling, Torstein Ragnar (2019). The Fronto-Temporal Orbito-Zygomatic Craniotomy.
• Meling, Torstein Ragnar (2019). The Supraorbital Craniotomy.
• Meling, Torstein Ragnar (2019). The bifrontal approach.
• Meling, Torstein Ragnar (2019). The bifrontal approach.
• Meling, Torstein Ragnar (2019). The interfacial technique for pterional craniotomy.
• Meling, Torstein Ragnar (2019). The one-layer technique for pterional craniotomy.
• Meling, Torstein Ragnar (2019). The one-layer technique for pterional craniotomy.

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