Tuula Anneli Nyman
Leder for Kjernefasiliteten for proteomikk
https://www.ous-research.no/proteomics/
Primære forskningsfelt: proteomikk, biologisk massespektrometri, bioinformatikk, medfødt immunitet, cellesignalisering
Utvalgte publikasjoner
Selected recent publications
Cypryk W, Nyman TA, Matikainen S. From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response? Front Immunol. 2018 Sep 25;9:2188.
Nyman TA, Lorey MB, Cypryk W, Matikainen S. Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells. Expert Rev Proteomics. 2017 May;14(5):395-407
Lorey MB, Rossi K, Eklund KK, Nyman TA*, Matikainen S*. Global characterization of protein secretion from human macrophages following non-canonical caspase-4/5 inflammasome activation. Mol Cell Proteomics. 2017 Feb 14. [Epub ahead of print]
Cypryk W, Lorey M, Puustinen A, Nyman TA, Matikainen S. Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. J Proteome Res. 2017;16:217-227
Söderholm S, Fu Y, Gaelings L, Belanov S, Yetukuri L, Berlinkov M, Cheltsov AV, Anders S, Aittokallio T, Nyman TA, Matikainen S, Kainov DE. Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.Viruses. 2016 Sep 29;8(10). pii: E269. Review.
Välimäki E, Cypryk W, Virkanen J, Nurmi K, Turunen PM, Eklund KK, Åkerman KE, Nyman TA, Matikainen S. Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages. J Immunol. 2016;197:3315-3325
Söderholm S, Kainov DE, Öhman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S*, Nyman TA*. Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages. Mol Cell Proteomics. 2016;15:3203-3219
Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016;35:1385-99.
Öhman T, Söderholm S, Paidikondala M, Lietzén N, Matikainen S, Nyman TA. Phosphoproteome characterization reveals that Sendai-virus infection activates mTOR signaling in human epithelial cells. Proteomics. 2015;15:2087-97.
Öhman T, Söderholm S, Hintsanen P, Välimäki E, Lietzén N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA. Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic dsRNA Recognition Pathway. Mol Cell Proteomics. 2014;13,2604-17.
Cypryk W, Öhman T, Eskelinen E-L, Matikainen S, Nyman TA. Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation. J Proteome Res. 2014;13:2468-77.
Öhman T, Teirilä L, Lahesmaa AM, Kankkunen P, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA*, Matikainen S*. Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages, J Immunol. 2014;192:5952-62.
Välimäki E, Miettinen J, Lietzén N, Matikainen S*, Nyman TA*. Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages. Mol Cell Proteomics. 2013;12:749-63.
Miettinen JJ, Matikainen S, Nyman TA. Global secretome characterisation of Herpes simplex virus 1 infected human primary macrophages, J Virol. 2012;86:12770-8.
Lietzén N, Öhman T*, Rintahaka J*, Julkunen I, Aittokallio T, Matikainen S*, Nyman TA*. Quantitative subcellular proteome and secretome profiling of Influenza A virus-infected human primary macrophages. PLoS Pathogens 2011 May;7(5):e1001340.
*equal contribution