Disputation: Julia-Kristina Jensen Madsen-Østerbye
M.Sc. Julia-Kristina Jensen Madsen-Østerbye will be defending the thesis titled, "Studies of hematopoiesis – physiologic and malignant development"
Photo: John Hughes
Trial lecture - time and place
Julia will give a trial lecture titled, "iPSC derived Haematopoietic Stem Cells - mechanisms and clinical potential" on 25 May at 10:15am, in Seminar Room 1 B2.U001, Rikshospitalet B. More information here.
- First Opponent: Lorena Arranz, Group Leader, The Arctic University of Norway (UiT)
- Second Opponent: Professor Odd Stokke Gabrielsen, Department of Biosciences, UiO
- Chair of the Committee: Jodie Goodridge, Researcher, Institute of Clinical medicine, UiO
Chair of defence
Professor Erlend Arnulf Nagelhus
Judith Staerk, Group Leader, Centre for Molecular Medicine Norway, UiO.
Stem cells respond to differentiation signals such as cytokines and growth factors, which regulate the expression of lineage specific genes. This results in differentiation of pluripotent embryonic or multipotent adult stem cells into mature somatic cells with high specialization. One such process is the ongoing formation of blood cells throughout life called hematopoiesis. Hematopoietic stem cells in the bone marrow are able to both proliferate and differentiate into various blood lineage cells in a precise and tightly regulated manner.
However, the molecular process underlying physiologic and malignant hematopoiesis remains incompletely understood. In these studies we identified several genes, transcription factors and pathways, which may influence the differentiation of hematopoietic progenitors into mature monocytes. We also established in vitro erythroid and monocyte differentiation protocols, which enable us to model hematopoiesis in vitro both under physiologic and malignant conditions.
Further, we show that B cells in chronic lymphocytic leukemia accumulate at the stage of cytokinesis exit. Overall, our the data included in these studies give new insight to the regulation of human hematopoietic development.