NCMM Tuesday Seminar: Thomas Arnesen

NCMM Associate Investigator Professor Thomas Arnesen, Department of Molecular Biology, University of Bergen and Department of Surgery, Haukeland University Hospital, will present his research as part of the NCMM Tuesday Seminar Series.

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Seminar title: Protein N-terminal Acetylation – From Machinery to Disease


Most human proteins are N-terminally acetylated. In recent years, we have identified and defined the responsible machinery in human cells, the N-terminal acetyltransferases (NATs). These may act as ribosome-associated co-translational modifiers of large substrate groups, or post-translationally on specific protein substrates. In the latter group, the Golgi-associated NAA60 acts on specific membrane proteins while the cytosolic NAA80 acetylates the N-termini of actins. At the protein level, the impact of N-terminal acetylation is very diverse and ranges from subcellular targeting to protein degradation or stabilization. The physiological importance is stressed by the pathologies caused by dysfunctional NAT enzymes. N-terminal acetylation may impact both cancer and neurodegenerative disease.

Published Jan. 12, 2022 11:50 AM - Last modified Aug. 17, 2022 5:59 PM