Review published for Sekulic Group
Article 'CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology' published in the journal Essays in Biochemistry
Many congratulations to the Sekulic Group on their review article, which has been published in the the journal Essays in Biochemistry.
The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, we summarize findings from recent structural biology studies, including several CryoEM structures, that contributed to elucidate specific features of the CENP-A nucleosome and molecular determinants of its interactions with CENP-C and CENP-N, the only two centromere proteins that directly bind to it. Based on those findings, we propose a role of the CENP-A nucleosome in the organization of centromeric chromatin beyond binding centromeric proteins.
You can read the article in full via the Essays in Biochemistry website: 'CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology'. Ahmad Ali Ahmad and Nikolina Sekulic. Essays Biochem (2020) 64 (2): 205–221.