Irep Gözen

• Schanke, Ingrid Jin; Xue, Lin; Spustova, Karolina & Gözen, Irep (2022). Transport among protocells via tunneling nanotubes. Nanoscale. ISSN 2040-3364. 14(29), p. 10418–10427. doi: 10.1039/d2nr02290g.
• Gözen, Irep; Köksal, Elif; Põldsalu, Inga; Xue, Lin; Spustova, Karolina & Pedrueza-Villalmanzo, Esteban [Show all 9 contributors for this article] (2022). Protocells: Milestones and Recent Advances. Small. ISSN 1613-6810. doi: 10.1002/smll.202106624.
• Köksal, Elif; Põldsalu, Inga; Friis, Henrik; Mojzsis, Stephen J; Bizzarro, Martin & Gözen, Irep (2022). Spontaneous formation of prebiotic compartment colonies on Hadean Earth and pre-Noachian Mars. chemsystemschem. ISSN 2570-4206. 4(3). doi: 10.1002/syst.202100040. Full text in Research Archive
• Spustova, Karolina; Xue, Lin; Ryskulov, Ruslan; Jesorka, Aldo & Gözen, Irep (2021). Manipulation of Lipid Membranes with Thermal Stimuli, Membrane Lipids. Springer. ISSN 978-1-0716-1842-4. p. 209–225.
• Põldsalu, Inga; Köksal, Elif & Gözen, Irep (2021). Mixed fatty acid-phospholipid protocell networks. bioRxiv. ISSN 2692-8205. doi: 10.1101/2021.03.08.434432.
• Gözen, Irep (2021). Did Solid Surfaces Enable the Origin of Life? Life. ISSN 2075-1729. doi: 10.3390/life11080795. Full text in Research Archive
• Schanke, Ingrid Jin; Xue, Lin; Spustova, Karolina & Gözen, Irep (2021). Transport among protocells via tunneling nanotubes. bioRxiv. ISSN 2692-8205. doi: 10.1101/2021.09.16.460285.
• Spustova, Karolina; Katke, Chinmay; Villalmanzo, Esteban Pedrueza; Ryskulov, Ruslan; Kaplan, C. Nadir & Gözen, Irep (2021). Colony-like Protocell Superstructures. bioRxiv. ISSN 2692-8205. doi: 10.1101/2021.09.16.460583.
• Põldsalu, Inga; Köksal, Elif & Gözen, Irep (2021). Mixed fatty acid-phospholipid protocell networks. Physical Chemistry, Chemical Physics - PCCP. ISSN 1463-9076. 23(47), p. 26948–26954. doi: 10.1039/d1cp03832j. Full text in Research Archive
• Köksal, Elif; Liese, Susanne; Xue, Lin; Ryskulov, Ruslan; Viitala, Lauri & Carlson, Andreas [Show all 7 contributors for this article] (2020). Rapid Growth and Fusion of Protocells in Surface‐Adhered Membrane Networks. Small. ISSN 1613-6810. 16(38). doi: 10.1002/smll.202002529.
• Gözen, Irep & Dommersnes, Paul Gunnar (2020). Biological lipid nanotubes and their potential role in evolution. The European Physical Journal Special Topics. ISSN 1951-6355. 229(17-18), p. 2843–2862. doi: 10.1140/epjst/e2020-000130-7. Full text in Research Archive
• Spustová, Karolina; Köksal, Elif; Ainla, Alar & Gözen, Irep (2020). Subcompartmentalization and Pseudo‐Division of Model Protocells. Small. ISSN 1613-6810. 17(2). doi: 10.1002/smll.202005320.
• Joemetsa, Silver; Spustová, Karolina; Kustanovich, Kiryl; Ainla, Alar; Schindler, Severin & Eigler, Siegfried [Show all 10 contributors for this article] (2019). Molecular Lipid Films on Microengineering Materials. Langmuir. ISSN 0743-7463. 35(32), p. 10286–10298. doi: 10.1021/acs.langmuir.9b01120.
• Kustanovich, Kiryl; Yantchev, Ventsislav; Doosti, Baharan Ali; Gözen, Irep & Jesorka, Aldo (2019). A microfluidics-integrated impedance/surface acoustic resonance tandem sensor. Sensing and Bio-Sensing Research. 25. doi: 10.1016/j.sbsr.2019.100291.
• Rydmark, Marcella Orwick; Christensen, Mikkel; Köksal, Elif; Kantarci, Ilayda; Kustanovich, Kiryl & Yantchev, Ventsislav [Show all 8 contributors for this article] (2019). Styrene maleic acid copolymer induces pores in biomembranes . Soft Matter. ISSN 1744-683X. 15(39), p. 7934–7944. doi: 10.1039/C9SM01407A. Full text in Research Archive
• Gözen, Irep (2019). A Hypothesis for Protocell Division on the Early Earth. ACS Nano. ISSN 1936-0851. 13(10), p. 10869–10871. doi: 10.1021/acsnano.9b06584.
• Köksal, Elif; Belletati, Patrícia Fernandes; Reint, Ganna; Olsson, Ragni; Leitl, Kira & Kantarci, Ilayda [Show all 7 contributors for this article] (2019). Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum. Journal of Visualized Experiments. ISSN 1940-087X. 2019(143), p. 1–9. doi: 10.3791/58923. Full text in Research Archive
• Köksal, Elif; Liese, Susanne; Kantarci, Ilayda; Olsson, Ragni; Carlson, Andreas & Gözen, Irep (2019). Nanotube-Mediated Path to Protocell Formation. ACS Nano. ISSN 1936-0851. 13(6), p. 6867–6878. doi: 10.1021/acsnano.9b01646. Full text in Research Archive
• Horowitz, Viva R; Chambers, Zachary C; Gözen, Irep; Dimiduk, Thomas G & Manoharan, Vinothan N (2019). Active colloidal particles in emulsion droplets: a model system for the cytoplasm. The European Physical Journal Special Topics. ISSN 1951-6355. 227(17), p. 2413–2424. doi: 10.1140/epjst/e2019-800026-y.
• Gupta, Abhay; Gözen, Irep & Taylor, Michael (2019). A cellular automaton for modeling non-trivial biomembrane ruptures. Soft Matter. ISSN 1744-683X. 15(20), p. 4178–4186. doi: 10.1039/c8sm02032a. Full text in Research Archive
• Bilal, Taylan & Gözen, Irep (2017). Formation and dynamics of endoplasmic reticulum-like lipid nanotube networks. Biomaterials Science. ISSN 2047-4830. 5(7), p. 1256–1264. doi: 10.1039/c7bm00227k.
• Taylor, Michael; Gözen, Irep; Patel, Samir; Jesorka, Aldo & Bertoldi, Katia (2016). Peridynamic Modeling of Ruptures in Biomembranes. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0165947.
• Gözen, Irep & Jesorka, Aldo (2015). Lipid nanotube networks: Biomimetic Cell-to-Cell Communication and Soft-Matter Technology. Nanofabrication. ISSN 2299-680X. 2, p. 27–31. doi: 10.1515/nanofab-2015-0003.
• Luo, ZhengYuan; Güven, Sinan; Gözen, Irep; Chen, Pu; Tasoglu, Savas & Anchan, Raymond M [Show all 8 contributors for this article] (2015). Deformation of a single mouse oocyte in a constricted microfluidic channel. Microfluidics and Nanofluidics. ISSN 1613-4982. 19, p. 883–890. doi: 10.1007/s10404-015-1614-0.
• Gözen, Irep & Dommersnes, Paul Gunnar (2014). Pore dynamics in lipid membranes. The European Physical Journal Special Topics. ISSN 1951-6355. 223, p. 1813–1829. doi: 10.1140/epjst/e2014-02228-5.
• El Assal, Rami; Güven, Sinan; Gürkan, Umut Atakan; Gözen, Irep; Shafiee, Hadi & Dalbeyler, Sedef [Show all 18 contributors for this article] (2014). Bio-Inspired Cryo-Ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification. Advanced Materials. ISSN 0935-9648. 26, p. 5815–5822. doi: 10.1002/adma.201400941.
• Gözen, Irep; Örtmen, Bahanur; Põldsalu, Inga; Dommersnes, Paul Gunnar; Orwar, Owe & Jesorka, Aldo (2013). Repair of large area pores in supported double bilayers. Soft Matter. ISSN 1744-683X. 9, p. 2787 –2792. doi: 10.1039/C3SM27429B.
• Ainla, Alar; Gözen, Irep; Hakonen, Bodil & Jesorka, Aldo (2013). Lab on a Biomembrane: Rapid prototyping and manipulation of 2D fluidic lipid bilayer circuits. Scientific Reports. ISSN 2045-2322. 3. doi: 10.1038/srep02743.
• Gözen, Irep; Shaali, Mehrnaz; Ainla, Alar; Örtmen, Bahanur; Põldsalu, Inga & Kustanovich, Kiryl [Show all 10 contributors for this article] (2013). Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks. Lab on a Chip. ISSN 1473-0197. 13, p. 3822 –3826. doi: 10.1039/C3LC50391G.
• Gözen, Irep & Jesorka, Aldo (2012). Instrumental Methods to Characterize Molecular Phospholipid Films on Solid Supports. Analytical Chemistry. ISSN 0003-2700. 84 (2), p. 822–838. doi: 10.1021/ac203126f.
• Gözen, Irep; Dommersnes, Paul Gunnar; Orwar, Owe & Jesorka, Aldo (2012). Evidence for membrane flow through pores in stacked phospholipid membranes. Soft Matter. ISSN 1744-683X. 8, p. 6220 –6225. doi: 10.1039/C2SM25629K.
• Gözen, Irep; Billerit, Celine; Dommersnes, Paul Gunnar; Jesorka, Aldo & Orwar, Owe (2011). Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles. Soft Matter. ISSN 1744-683X. 7, p. 9706–9713 . doi: 10.1039/C1SM05677H.
• Gözen, Irep & Örmeci, Banu (2010). Effect of daylight on regrowth of bacteria in anaerobically digested sludge. Water Science and Technology. ISSN 0273-1223. 62 (2) , p. 364–369. doi: 10.2166/wst.2010.268.
• Lobovkina, Tatsiana; Gözen, Irep; Erkan, Yavuz; Olofsson, Jessica; Weber, Stephen G. & Orwar, Owe (2010). Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients. Soft Matter. ISSN 1744-683X. 6, p. 268 –272. doi: 10.1039/B916805M.
• Gözen, Irep; Dommersnes, Paul Gunnar; Czolkos, Ilja; Jesorka, Aldo; Lobovkina, Tatsiana & Orwar, Owe (2010). Fractal avalanche ruptures in biological membranes. Nature Materials. ISSN 1476-1122. 9, p. 908–912. doi: 10.1038/nmat2854.
• Ainla, Alar; Gözen, Irep; Orwar, Owe & Jesorka, Aldo (2009). A Microfluidic Diluter Based on Pulse Width Flow Modulation. Analytical Chemistry. ISSN 0003-2700. 81 (13), p. 5549–5556. doi: 10.1021/ac9010028.

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• Gözen, Irep; Dommersnes, Paul Gunnar & Jesorka, Aldo (2015). Lipid Self-Spreading on Solid Substrates. IntechOpen. ISBN 978-953-51-2216-6. 36 p.
• Gözen, Irep (2013). The self–spreading double bilayer/Advances in Lipid Membrane Nanotechnology. Chalmers University of Technology. ISBN 978-91-7385-813-7. 110 p.

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• Balaban, Theodor Silviu; Gözen, Irep & Jesorka, Aldo (2016). The Nobel Prize for Chemistry 2016 highlights tiny synthetic machines. NBS-nytt. ISSN 0801-3535. p. 11–11.
• Schanke, Ingrid Jin & Gözen, Irep (2021). Transport within protocell-nanotube networks and its implications for communication of primitive cells. Matematisk-naturvitenskapelig fakultet, Universitetet i Oslo. Show summary

  Protocells are self-organized primitive compartments which are thought to be precursors to first living cells at the origin of life. Several different types of model protocell structures have been proposed; among them, the most recently identified protocell nanotube networks (PNNs). A PNN consists of tens of surface adhered lipid compartments physically connected via lipid nanotubes. In this work, it is shown for the first time using differential interference contrast (DIC) microscopy that the PNNs can successfully form by using lipid compositions that are completely label-free. It has also been shown via confocal microscopy that the lipid nanotubes allow the transport of fluorescently labeled water soluble compounds, RNA and DNA among the compartments in the network. By employing fluorescence recovery after photobleaching (FRAP) technique, the diffusive redistribution of encapsulated fluorophores among compartments that are not in direct contact with each other, has been depicted. Results show that the transportation of the compounds in PNNs is possible due to the interconnecting nanotubes, which is proposed as a plausible chemical communication and replication mechanism between the protocells on the early Earth.

• Köksal, Elif; Gözen, Irep; Lund, Reidar & Carlson, Andreas (2021). Surface-assisted formation and development of model protocells. Universitetet i Oslo, Det matematisk-naturvitenskapelige fakultet. ISSN 1501-7710. 2021(2401). Show summary

  By enabling formation and development of primitive cells, also known as protocells, solid surfaces might have played an important role in the emergence of life on Earth. Current theories on how life originated from primitive cells are based on the initial step, where a spherical capsule made from fat molecules formed spontaneously in water. This model explains the formation well, but not the following steps, such as growth, replication and division. In this PhD thesis, the possible involvement of solid surfaces in the formation and development of primitive cells has been investigated. Solid surfaces existed in the form of rocks and minerals on the early Earth. By bringing together three simple ingredients: solid surfaces, fat molecules and water, and observing their interactions by means of microscopy, a series of unique transformations has been identified. Examples of such behavior are the formation of protocell networks connected with lipid nanotubes, formation of subcompartments similar to organelles in modern cells, protocell fusion and colony formation. Nano-engineered artificial surfaces, as well as natural surfaces including glasses, minerals, rocks, and a meteorite fragment from Mars originating from the earliest crust of the planet were used in the studies.

• Spustova, Karolina; Gözen, Irep; Lund, Reidar & Carlson, Andreas (2021). Membranous Protocell Superstructures. Universitetet i Oslo, Det matematisk-naturvitenskapelige fakultet. ISSN 1501-7710. 2021(2467). Show summary

  How primitive cells emerged and developed on the early Earth remain an unsolved question. In contrast to the hypotheses that the first living cells evolved from a single ancestor, their development as colonies would provide numerous advantages, such as mechanical stability, enhancement of chemical reactions, and sharing of prebiotic molecules. In this PhD thesis, the formation and development of colony-like primitive cell structures and populations was investigated using three simple ingredients: water, fat molecules and solid surfaces. Transformation of fat agglomerates into large populations of structured primitive cells that are able to communicate and migrate, was observed under a light microscope. The role of solid surfaces which were abundant on the early Earth in form of rocks and minerals, was shown to be fundamental for these processes. These findings make us rethink the current theories on how life originated and show that solid surfaces might have played an important role in the emergence of primitive cells on the early Earth.

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