Joel Benjamin Heim

Image of Joel Benjamin Heim
Norwegian version of this page
Phone +47-22855465
Username
Visiting address Gaustadalléen 21 Forskningsparken bygg D - plan 3 0349 OSLO
Postal address Postboks 1137 Blindern 0318 OSLO
Other affiliations Department of Chemistry

Academic interests

  • Biochemistry
  • Structure-guided drug discovery
  • X-ray crystallography

Background

  • 2015 – 2019: PhD candidate at the Department of Chemistry , University of Oslo
    Thesis: “Pulling the “sweet tooth” of bacterial toxins – An investigation using X-ray crystallography and carbohydrate interaction analysis”, supervised by Ute Krengel

  • 2012 – 2015: Master in Biochemistry (M. Sc.), University Tübingen
    Thesis: “Focal Adhesion Kinase: Role of Tyrosine 397 for Development and Epidermal Homeostasis”, supervised by Alexander Meves, M.D. (Mayo Clinic, Rochester, MN)

  • 2009 – 2012: Bachelor in Biochemistry (B. Sc.), University Tübingen

 

 

Publications

  • Heggelund, Julie Elisabeth; Heim, Joel Benjamin; Bajc, Gregor; Hodnik, Vesna; Anderluh, Gregor & Krengel, Ute (2019). Specificity of Escherichia coli heat-Labile enterotoxin investigated by single-site mutagenesis and crystallography. International Journal of Molecular Sciences.  ISSN 1422-0067.  20(3) . doi: 10.3390/ijms20030703 Full text in Research Archive.
  • Heim, Joel Benjamin; Hodnik, Vesna; Heggelund, Julie Elisabeth; Anderluh, Gregor & Krengel, Ute (2019). Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site. Scientific Reports.  ISSN 2045-2322.  9 . doi: 10.1038/s41598-019-48579-2
  • Burschowsky, Daniel; Thorbjørnsrud, Helen Vikdal; Heim, Joel Benjamin; Fahrig-Kamarauskaite, Jurate; Würth-Roderer, Kathrin; Kast, Peter & Krengel, Ute (2018). Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp. Biochemistry.  ISSN 0006-2960.  57(5), s 557- 573 . doi: 10.1021/acs.biochem.7b01018 Full text in Research Archive.
  • Heggelund, Julie Elisabeth; Mackenzie, Alasdair; Martinsen, Tobias; Heim, Joël Benjamin; Cheshev, Pavel; Bernardi, Anna & Krengel, Ute (2017). Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Scientific Reports.  ISSN 2045-2322.  7(2326) . doi: 10.1038/s41598-017-02179-0 Full text in Research Archive.

View all works in Cristin

  • Heim, Joel Benjamin; Teter, Kenneth & Krengel, Ute (2018). Towards the molecular basis for the differential toxicity of cholera toxin and heat-labile enterotoxin.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2017). Structural Studies on Cholera.
  • Heim, Joël Benjamin (2016). Bacterial toxins.
  • Heim, Joël Benjamin (2016). Cholera - new medicine.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). How does blood group secretor status protect from cholera intoxication? – Structure and interaction analysis of carbohydrate binding.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.

View all works in Cristin

Published Oct. 3, 2019 11:29 AM - Last modified Oct. 10, 2019 5:49 PM

Research groups