Nikolai Engedal

Image of Nikolai Engedal
Norwegian version of this page
Phone +47-22840765
Username
Visiting address Gaustadalléen 21 Forskningsparken 0349 OSLO
Postal address Postboks 1137 Blindern 0318 OSLO

Current roles

Past roles

  • Previously a member of the Ian Mills Prostate Cancer Group.
Tags: Cell death, Cancer, Membrane trafficking, Cancer research, Cell biology, Cell signalling, Autophagy

Publications

  • Engedal, Nikolai; Žerovnik, Eva; Rudov, Alexander; Galli, Francesco; Olivieri, Fabiola; Procopio, Antonio Domenico; Rippo, Maria Rita; Monsurrò, Vladia; Betti, Michele & Albertini, Maria Cristina (2018). From oxidative stress damage to pathways, networks and autophagy via microRNAs. Oxidative Medicine and Cellular Longevity.  ISSN 1942-0900. . doi: 10.1155/2018/4968321
  • Luhr, Morten; Szalai, Paula & Engedal, Nikolai (2018). The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells. Journal of Visualized Experiments.  ISSN 1940-087X.  137(137) . doi: 10.3791/57971
  • Luhr, Morten; Sætre, Frank & Engedal, Nikolai (2018). The Long-lived Protein Degradation Assay: an efficient method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in adherent cell lines. Bio-protocol.  ISSN 2331-8325.  8(9) . doi: 10.21769/BioProtoc.2836
  • Mauthe, Mario; Orhon, Idil; Rocchi, Cecilia; Zhou, Xingdong; Luhr, Morten; Hijlkema, Kerst-Jan; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel & Reggiori, Fulvio (2018). Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy.  ISSN 1554-8627.  14(8), s 1435- 1455 . doi: 10.1080/15548627.2018.1474314
  • Pajares, Marta; Cuadrado, A.; Engedal, Nikolai; Jirsova, Z. & Cahova, M (2018). The role of free radicals in autophagy regulation: Implications for ageing. Oxidative Medicine and Cellular Longevity.  ISSN 1942-0900. . doi: 10.1155/2018/2450748
  • Szalai, Paula & Engedal, Nikolai (2018). An Image-based Assay for High-throughput Analysis of Cell Proliferation and Cell Death of Adherent Cells. Bio-protocol.  ISSN 2331-8325.  8(9) . doi: 10.21769/BioProtoc.2835
  • Szalai, Paula; Parys, Jan B; Bultynck, Geert; Christensen, Søren Brøgger; Nissen, Poul; Møller, Jesper Vuust & Engedal, Nikolai (2018). Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death. Cell Calcium.  ISSN 0143-4160.  76, s 48- 61 . doi: doi.org/10.1016/j.ceca.2018.09.005
  • Kjos, Ingrid; Distefano, Marita Borg; Sætre, Frank Ove; Repnik, Urska; Holland, Petter; Jones, Arwyn T; Engedal, Nikolai; Simonsen, Anne; Bakke, Oddmund & Progida, Cinzia (2017). Rab7b modulates autophagic flux by interacting with Atg4B. EMBO Reports.  ISSN 1469-221X.  18(10), s 1727- 1739 . doi: 10.15252/embr.201744069 Full text in Research Archive.
  • Luhr, Morten; Szalai, Paula; Sætre, Frank; Gerner, Lisa; Seglen, Per O. & Engedal, Nikolai (2017). A simple cargo sequestration assay for quantitative measurement of non-selective autophagy in cultured cells. Methods in Enzymology.  ISSN 0076-6879.  587, s 351- 364 . doi: 10.1016/bs.mie.2016.09.064
  • Sehgal, Pankaj; Szalai, Paula; Olesen, Claus; Praetorius, Helle A.; Nissen, Poul; Christensen, Søren Brøgger; Engedal, Nikolai & Møller, Jesper Vuust (2017). Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response. Journal of Biological Chemistry.  ISSN 0021-9258.  292(48), s 19656- 19673 . doi: 10.1074/jbc.M117.796920
  • Vdovikova, Svitlana; Luhr, Morten; Szalai, Paula; Nygård Skalman, L; Francis, Monika K; Lundmark, Richard; Engedal, Nikolai; Johansson, Jørgen & Wai, Sun N (2017). A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death.. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  3 . doi: 10.3389/fcimb.2017.00154
  • Engedal, Kim Nikolai & Seglen, Per O. (2016). Autophagy of cytoplasmic bulk cargo does not require LC3. Autophagy.  ISSN 1554-8627.  12(2), s 439- 441 . doi: 10.1080/15548627.2015.1076606
  • Itkonen, Harri; Engedal, Kim Nikolai; Babaie, Eshrat; Luhr, Morten; Guldvik, Ingrid Jenny; Minner, S; Hohloch, J; Tsourlakis, MC; Schlomm, Thorsten & Mills, Ian Geoffrey (2015). UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation. Oncogene.  ISSN 0950-9232.  34(28), s 3744- 3750 . doi: 10.1038/onc.2014.307
  • Seglen, Per O.; Luhr, Morten; Mills, Ian Geoffrey; Sætre, Frank; Szalai, Paula & Engedal, Kim Nikolai (2015). Macroautophagic cargo sequestration assays. Methods.  ISSN 1046-2023.  75, s 25- 36 . doi: 10.1016/j.ymeth.2014.12.021
  • Szalai, Paula; Hagen, Linda K Korsberg; Sætre, Frank; Luhr, Morten; Sponheim, Marianne; Øverbye, Anders; Mills, Ian Geoffrey; Seglen, Per O. & Engedal, Kim Nikolai (2015). Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. Experimental Cell Research.  ISSN 0014-4827.  333(1), s 21- 38 . doi: 10.1016/j.yexcr.2015.02.003
  • Sætre, Frank; Hagen, Linda K Korsberg; Engedal, Kim Nikolai & Seglen, Per O. (2015). Novel steps in the autophagic-lysosomal pathway. The FEBS Journal.  ISSN 1742-464X.  282(11), s 2202- 2214 . doi: 10.1111/febs.13268
  • Engedal, Kim Nikolai & Mills, Ian Geoffrey (2014). Endosomal signalling and oncogenesis. Methods in Enzymology.  ISSN 0076-6879.  535, s 179- 200 . doi: 10.1016/B978-0-12-397925-4.00012-2
  • Engedal, Kim Nikolai; Torgersen, Maria Lyngaas; Guldvik, Ingrid Jenny; Barfeld, Stefan; Bakula, D; Sætre, Frank Ove; Hagen, Linda K Korsberg; Patterson, J; Proikas-Cezanne, T; Seglen, Per O.; Simonsen, Anne & Mills, Ian Geoffrey (2013). Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy.  ISSN 1554-8627.  9(10), s 1475- 1490 . doi: 10.4161/auto.25900
  • Kvalvaag, Audun Sverre Myrset; Pust, Sascha; Sundet, Kristine Ingrid; Simm, Roger; Sandvig, Kirsten & Engedal, Kim Nikolai (2013). The ERM Proteins Ezrin and Moesin Regulate Retrograde Shiga Toxin Transport. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  14(7), s 839- 852 . doi: 10.1111/tra.12077
  • Torgersen, Maria Lyngaas; Engedal, Kim Nikolai; Bøe, Stig Ove; Hokland, Peter & Simonsen, Anne (2013). Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells. Blood.  ISSN 0006-4971.  122(14), s 2467- 2476 . doi: 10.1182/blood-2013-05-500629
  • Engedal, Kim Nikolai (2011). Chapter seven - Immune Regulator Vitamin A and T Cell Death. Vitamines and Hormones.  ISSN 0083-6729.  86, s 153- 178 . doi: 10.1016/B978-0-12-386960-9.00007-1
  • Engedal, Kim Nikolai; Skotland, Tore; Torgersen, Maria Lyngaas & Sandvig, Kirsten (2011). Shiga toxin and its use in targeted cancer therapy and imaging. Microbial Biotechnology.  ISSN 1751-7907.  4(1), s 32- 46 . doi: 10.1111/j.1751-7915.2010.00180.x
  • Torgersen, Maria Lyngaas; Engedal, Kim Nikolai; Pedersen, Anne-Mari Gjestvang; Husebye, Harald; Espevik, Terje & Sandvig, Kirsten (2011). Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells. FEMS Immunology and Medical Microbiology.  ISSN 0928-8244.  61(1), s 63- 75 . doi: 10.1111/j.1574-695X.2010.00749.x
  • Sandvig, Kirsten; Torgersen, Maria Lyngaas; Engedal, Kim Nikolai; Skotland, Tore & Iversen, Tore Geir (2010). Protein toxins from plants and bacteria: Probes for intracellular transport and tools in medicine. FEBS Letters.  ISSN 0014-5793.  584(12), s 2626- 2634 . doi: 10.1016/j.febslet.2010.04.008
  • Torgersen, Maria Lyngaas; Engedal, Kim Nikolai; Bergan, Jonas & Sandvig, Kirsten (2010). The intracellular journey of Shiga toxins. Open Toxinology Journal.  ISSN 1875-4147.  3, s 3- 12
  • Engedal, Kim Nikolai; Auberger, P & Blomhoff, Heidi Kiil (2009). Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly. Journal of Leukocyte Biology.  ISSN 0741-5400.  85(3), s 469- 480 . doi: 10.1189/jlb.1107790
  • Engedal, Kim Nikolai; Gjevik, Tone; Blomhoff, Rune & Blomhoff, Heidi Kiil (2006). All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: Early induction of cyclin D3(1). Journal of Immunology.  ISSN 0022-1767.  177, s 2851- 2861
  • Engedal, Kim Nikolai; Ertesvåg, Åse & Blomhoff, Heidi Kiil (2004). Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2. International Immunology.  ISSN 0953-8178.  16, s 443- 453

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Published Dec. 5, 2016 4:45 PM - Last modified July 5, 2017 2:58 PM