Brain heterogeneity in schizophrenia
A new study from Dag Alnæs and collaborators shows that schizophrenia is associated with increased individual differences in brain structure as compared to healthy individuals.
Dag Alnæs. Photo: Kirsten Sjøwall
The results possibly reflect clinical heterogeneity, gene-environment interactions, or secondary disease factors, and suggest that important information may be overlooked when only assessing mean differences between patients and healthy individuals.
Read about the study in this JAMA Psychiatry editorial comment: Toward high reproducibility and accountable heterogeneity in schizophrenia research
Alnæs D, Kaufmann T, van der Meer D, Córdova-Palomera A, Rokicki J, Moberget T, Bettella F, Agartz I, Barch DM, Bertolino A, Brandt CL, Cervenka S, Djurovic S, Doan NT, Eisenacher S, Fatouros-Bergman H, Flyckt L, Di Giorgio A, Haatveit B, Jönsson EG, Kirsch P, Lund MJ, Meyer-Lindenberg A, Pergola G, Schwarz E, Smeland OB, Quarto T, Zink M, Andreassen OA, Westlye LT; Karolinska Schizophrenia Project Consortium. Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk. JAMA Psychiatry. 2019 Apr 10. doi: 10.1001/jamapsychiatry.2019.0257.