Define new targets to optimize the ratio of beneficial vs. adverse effects of antipsychotics
Antipsychotic medications are effective drugs for schizophrenia, and have in recent years also been used for bipolar disorder. The medications are not equally effective for all patients, and have a limited effect on the core symptoms for approximately 20 % of those treated. Side effects are problematic and in some cases serious, such as for instance cardiovascular risk factors (blodlipids, diabetes, weight gain etc).
Research at NORMENT has a particular focus on immune and lipid systems. We use animal models to enhance our knowledge about the mechanisms of action of antipsychotic medication. We aim to optimize antipsychotic treatment by contributing to increasing the desired effect of medication and reducing side effects.