Publikasjoner

  • Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings 11. aug. 2022 02:00
    Alcohol use disorder (AUD) is a pervasive and devastating mental illness with high comorbidity rates with other mental disorders. Understanding the genetic architecture of this comorbidity could be improved by focusing on intermediate traits that show positive genetic correlation with the disorders. Thus, we aimed to characterize the shared vs. unique polygenicity of AUD, alcohol consumption (AC) and mood instability (MOOD) -beyond genetic correlation, and boost discovery for jointly-associated...
  • Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia 11. aug. 2022 02:00
    INTRODUCTION: Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI).
  • Local molecular and global connectomic contributions to cross-disorder cortical abnormalities 10. aug. 2022 02:00
    Numerous brain disorders demonstrate structural brain abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these molecular and connectomic vulnerabilities to brain disorders remain unknown, and has yet to be studied in a single multi-disorder framework. Using MRI morphometry from the ENIGMA consortium, we construct maps of cortical abnormalities for thirteen neurodevelopmental, neurological, and psychiatric...
  • The association between personality traits and placebo effects: a preregistered systematic review and meta-analysis 10. aug. 2022 02:00
    Placebo effects are ubiquitous yet highly variable between individuals, and therefore strongly impact clinical trial outcomes such as pain relief. It is unclear whether dispositional psychological traits influence responsiveness to placebo. This preregistered meta-analysis and systematic review synthesized the literature investigating the association between personality traits and placebo effects. Based on 21 studies with 798 participants, we performed formal meta-analyses for 10 different...
  • The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health 8. aug. 2022 02:00
    Increasing evidence has shown adverse effects of loneliness on cardiometabolic health. The neuromodulator and hormone oxytocin has traditionally been linked with social cognition and behaviour. However, recent implications of the oxytocin system in energy metabolism and the overrepresentation of metabolic issues in psychiatric illness suggests that oxytocin may represent a mechanism bridging mental and somatic traits. To clarify the role of the oxytocin signalling system in the link between...
  • Developing "MinDag" - an app to capture symptom variation and illness mechanisms in bipolar disorder 8. aug. 2022 02:00
    INTRODUCTION: The illness course of bipolar disorder (BD) is highly heterogeneous with substantial variation between individuals with the same BD subtype and within individuals over time. This heterogeneity is not well-delineated and hampers the development of more targeted treatment. Furthermore, although lifestyle-related behaviors are believed to play a role in the illness course, such mechanisms are poorly understood. To address some of these knowledge gaps, we aimed to develop an app for...
  • Overactive, aggressive, disruptive and agitated behavior associated with the use of psychotropic medications in schizophrenia 7. aug. 2022 02:00
    CONCLUSIONS: Use of antipsychotics and antidepressants is associated with reduced risk of readmission with OADA whereas benzodiazepines are associated with an increased risk of readmission with OADA in patients with schizophrenia.
  • Association between polarity of first episode and solar insolation in bipolar I disorder 6. aug. 2022 02:00
    CONCLUSION: Increased awareness and research into circadian dysfunction throughout the course of BD is warranted.
  • Theory of mind in schizophrenia: a comparison of subgroups with low and high IQ 2. aug. 2022 02:00
    CONCLUSION: Global ToM impairment was present in the low IQ schizophrenia group. Overmentalizing was not present in the high IQ group and appears related to lower IQ. Intact higher-level reasoning may prevent the high IQ group from making overmentalizing errors, through self-monitoring or inhibition. We propose that high IQ patients are chiefly impaired in lower-level ToM, whereas low IQ patients also have impaired higher-level ToM. Conceivably, this specific impairment could help explain the...
  • Metabolite Profiling of Clozapine in Patients Switching Versus Maintaining Treatment: A Retrospective Pilot Study 2. aug. 2022 02:00
    PURPOSE/BACKGROUND: Pharmacokinetics may be of relevance for the risk of clozapine discontinuation. We compared metabolite profiles, accounting for smoking habits, in patients switching versus maintaining clozapine treatment at therapeutic concentrations.
Mer ...

 

Publisert 25. feb. 2014 11:43 - Sist endret 8. feb. 2019 06:31